losartan has been researched along with Carotid Artery Diseases in 7 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Carotid Artery Diseases: Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) study, there was a 25% risk reduction for stroke with angiotensin receptor blocker-based therapy (losartan) as compared with beta-blocker-based therapy (atenolol) despite comparable blood pressure reductions." | 9.12 | Long-term effects of a losartan- compared with an atenolol-based treatment regimen on carotid artery plaque development in hypertensive patients with left ventricular hypertrophy: ICARUS, a LIFE substudy. ( Fossum, E; Høieggen, A; Ibsen, H; Julius, S; Kjeldsen, SE; Olsen, MH; Reims, HM; Wachtell, K; Wan, Y, 2006) |
| "In the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) study, there was a 25% risk reduction for stroke with angiotensin receptor blocker-based therapy (losartan) as compared with beta-blocker-based therapy (atenolol) despite comparable blood pressure reductions." | 5.12 | Long-term effects of a losartan- compared with an atenolol-based treatment regimen on carotid artery plaque development in hypertensive patients with left ventricular hypertrophy: ICARUS, a LIFE substudy. ( Fossum, E; Høieggen, A; Ibsen, H; Julius, S; Kjeldsen, SE; Olsen, MH; Reims, HM; Wachtell, K; Wan, Y, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liebson, PR | 1 |
| Oliveira, RP | 1 |
| Joaquim, LF | 1 |
| Fazan, R | 1 |
| Salgado, MC | 1 |
| Salgado, HC | 1 |
| Uchiyama-Tanaka, Y | 1 |
| Mori, Y | 1 |
| Kishimoto, N | 1 |
| Fukui, M | 1 |
| Nose, A | 1 |
| Kijima, Y | 1 |
| Yamahara, H | 1 |
| Hasegawa, T | 1 |
| Kosaki, A | 1 |
| Matsubara, H | 1 |
| Iwasaka, T | 1 |
| Takai, S | 1 |
| Kirimura, K | 1 |
| Jin, D | 1 |
| Muramatsu, M | 1 |
| Yoshikawa, K | 1 |
| Mino, Y | 1 |
| Miyazaki, M | 1 |
| Fossum, E | 1 |
| Olsen, MH | 1 |
| Høieggen, A | 1 |
| Wachtell, K | 1 |
| Reims, HM | 1 |
| Kjeldsen, SE | 1 |
| Ibsen, H | 1 |
| Wan, Y | 1 |
| Julius, S | 1 |
| Taguchi, J | 1 |
| Abe, J | 1 |
| Ohno, M | 1 |
| Schwartz, SM | 1 |
| Kurokawa, K | 1 |
| van Kleef, EM | 1 |
| Fingerle, J | 1 |
| Daemen, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Triple-Blind, Parallel Study to Investigate the Effect of Losartan Versus Atenolol on the Reduction of Morbidity and Mortality in Hypertensive Patients With Left Ventricular Hypertrophy[NCT00338260] | Phase 3 | 496 participants (Actual) | Interventional | 1995-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for losartan and Carotid Artery Diseases
| Article | Year |
|---|---|
LIFE and ARBITER.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Atenolol; Atorvastatin; Carotid Artery Disease | 2003 |
Comparison of the effects of quinapril and losartan on carotid artery intima-media thickness in patients with mild-to-moderate arterial hypertension.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Carotid Artery Diseases; Female; Humans; Hypertension | 2005 |
Long-term effects of a losartan- compared with an atenolol-based treatment regimen on carotid artery plaque development in hypertensive patients with left ventricular hypertrophy: ICARUS, a LIFE substudy.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin II Type 1 Receptor Blockers; Arteriosclerosis; Atenol | 2006 |
4 other studies available for losartan and Carotid Artery Diseases
| Article | Year |
|---|---|
Neurohumoral mechanisms involved in the hypertensive response elicited by bilateral carotid occlusion in conscious intact or chronically sympathectomized rats.
Topics: Adrenal Glands; Adrenergic alpha-Antagonists; Angiotensin II Type 1 Receptor Blockers; Animals; Bloo | 2004 |
Significance of angiotensin II receptor blocker lipophilicities and their protective effect against vascular remodeling.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Blood P | 2005 |
Topical application of AT1 receptor antagonists prevents medial and neointimal proliferation after balloon injury.
Topics: Administration, Oral; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Arginine; | 1994 |
Angiotensin II-induced progression of neointimal thickening in the balloon-injured rat carotid artery is AT1 receptor mediated.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Carotid Arteries; Car | 1996 |