Page last updated: 2024-10-30

losartan and Cardiomyopathies

losartan has been researched along with Cardiomyopathies in 32 studies

Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position

Cardiomyopathies: A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).

Research Excerpts

ExcerptRelevanceReference
"Cardiac fibrosis is a severe condition with limited therapeutic options and often occurs in chronic cardiovascular diseases such as hypertension and myocardial infarction."5.72Integrin subunit β-like 1 mediates angiotensin II-induced myocardial fibrosis by regulating the forkhead box Q1/Snail axis. ( Chen, W; Han, L; Ji, H; Yu, L; Zhu, H, 2022)
"Recent studies showed that chronic administration of losartan, an angiotensin II type I receptor antagonist, improved skeletal muscle function in dystrophin-deficient mdx mice."5.37Losartan decreases cardiac muscle fibrosis and improves cardiac function in dystrophin-deficient mdx mice. ( Gordish-Dressman, H; Guerron, AD; Hoffman, EP; Iantorno, M; Nagaraju, K; Rayavarapu, S; Sali, A; Spurney, CF; van der Meulen, J; Yu, Q, 2011)
"Losartan treatment decreased systolic pressure and yellow-red collagen fiber content in all areas, whereas spironolactone treatment decreased green collagen fiber content without decreasing systolic pressure."5.29Left ventricular fibrosis in renovascular hypertensive rats. Effect of losartan and spironolactone. ( Appay, MD; Bariety, J; Heudes, D; Hinglais, N; Michel, JB; Nicoletti, A; Philippe, M; Sassy-Prigent, C, 1995)
" Methods Baseline and follow-up clinical and echocardiographic parameters were assessed in 939 hypertensive patients with electrocardiogram (ECG) LVH participating in the Losartan Intervention for Endpoint reduction in hypertension (LIFE) echocardiography substudy (66±7 years; 42% women; 11% with diabetes) who did not have aortic or mitral valve stenosis or prosthesis."3.79Mitral annular calcification and incident ischemic stroke in treated hypertensive patients: the LIFE study. ( Boman, K; Casalnuovo, G; Dahlöf, B; De Marco, M; de Simone, G; Devereux, RB; Gerdts, E; Kizer, JR; Migliore, T; Olsen, MH; Wachtell, K, 2013)
" The aim of this work was to assess the impact of hemin (heme oxygenase-1 inducer) on NADPH oxidase activation, cardiac oxidative stress, and development of fibrosis in a rat model of renovascular hypertensive cardiomyopathy in comparison to an anti-hypertensive reference treatment with losartan."3.77Hemin decreases cardiac oxidative stress and fibrosis in a rat model of systemic hypertension via PI3K/Akt signalling. ( Belmokhtar, K; Bonnet, P; Eder, V; Khamis, G; Machet, MC; Vourc'h, P; Worou, ME, 2011)
" This case report presents the successful treatment of severe heart failure with prednisone, glycosides and an angiotensin-1 receptor antagonist."3.70[Heart failure as a cardiac symptom of sarcoidosis. Successful treatment of heart failure with steroids, digitalis and an angiotensin-1-receptor antagonist in sarcoidosis]. ( Erbel, R; Kuntz, S; Oldenburg, O; Philipp, T; Sack, S; Schäfers, RF; Weber, F, 2000)
"The dystrophinopathies include Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), and X-linked dilated cardiomyopathy (XLDCM)."2.58Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X-linked dilated cardiomyopathy. ( Bourke, JP; Bueser, T; Quinlivan, R, 2018)
"Cardiac fibrosis is a severe condition with limited therapeutic options and often occurs in chronic cardiovascular diseases such as hypertension and myocardial infarction."1.72Integrin subunit β-like 1 mediates angiotensin II-induced myocardial fibrosis by regulating the forkhead box Q1/Snail axis. ( Chen, W; Han, L; Ji, H; Yu, L; Zhu, H, 2022)
"Recent studies showed that chronic administration of losartan, an angiotensin II type I receptor antagonist, improved skeletal muscle function in dystrophin-deficient mdx mice."1.37Losartan decreases cardiac muscle fibrosis and improves cardiac function in dystrophin-deficient mdx mice. ( Gordish-Dressman, H; Guerron, AD; Hoffman, EP; Iantorno, M; Nagaraju, K; Rayavarapu, S; Sali, A; Spurney, CF; van der Meulen, J; Yu, Q, 2011)
"Losartan treatment resulted in improvement of myocardial function and suppressed cardiac and renal fibrosis compared with the diabetic group."1.35Effects of angiotensin receptor blocker on oxidative stress and cardio-renal function in streptozotocin-induced diabetic rats. ( Aizawa, Y; Arozal, W; Kodama, M; Ma, M; Suzuki, K; Tachikawa, H; Thandavarayan, RA; Veeraveedu, PT; Watanabe, K, 2009)
"Celiac disease is associated frequently with iron deficiency anemia, dermatitis herpetiformis, selective IgA deficiency, thyroid disorders, diabetes mellitus, and various connective tissue disorders but is rarely associated with cardiomyopathy."1.33Cardiomyopathy associated with celiac disease. ( Goel, NK; Kamath, PS; McBane, RD, 2005)
"Losartan treatment was associated with significant attenuation of MMP activities in cardiomyopathic samples at 65 and 120 days."1.30Cardiac collagen remodeling in the cardiomyopathic Syrian hamster and the effect of losartan. ( Dixon, IM; Jasmin, G; Ju, H; Reid, NL; Scammell-La Fleur, T; Werner, JP, 1997)
"Losartan treatment decreased systolic pressure and yellow-red collagen fiber content in all areas, whereas spironolactone treatment decreased green collagen fiber content without decreasing systolic pressure."1.29Left ventricular fibrosis in renovascular hypertensive rats. Effect of losartan and spironolactone. ( Appay, MD; Bariety, J; Heudes, D; Hinglais, N; Michel, JB; Nicoletti, A; Philippe, M; Sassy-Prigent, C, 1995)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (12.50)18.2507
2000's14 (43.75)29.6817
2010's8 (25.00)24.3611
2020's6 (18.75)2.80

Authors

AuthorsStudies
Kovács, ZZA2
Szűcs, G2
Freiwan, M2
Kovács, MG2
Márványkövi, FM1
Dinh, H2
Siska, A2
Farkas, K1
Kovács, F2
Kriston, A2
Horváth, P2
Kővári, B1
Cserni, BG1
Cserni, G2
Földesi, I2
Csont, T2
Sárközy, M2
Yokota, T1
Koiwa, H1
Matsushima, S1
Tsujinaga, S1
Naya, M1
Morisaki, H1
Morisaki, T1
Losonczi, R1
Dux, L1
Chen, XS1
Wang, SH1
Liu, CY1
Gao, YL1
Meng, XL1
Wei, W1
Shou, ST1
Liu, YC1
Chai, YF1
Zhu, H1
Ji, H1
Chen, W1
Han, L1
Yu, L1
Wang, EY1
Kuzmanov, U1
Smith, JB1
Dou, W1
Rafatian, N1
Lai, BFL1
Lu, RXZ1
Wu, Q1
Yazbeck, J1
Zhang, XO1
Sun, Y1
Gramolini, A1
Radisic, M1
Bourke, JP1
Bueser, T1
Quinlivan, R1
Chamorro-Pareja, N1
Marin-Acevedo, JA1
Chirilă, RM1
Meyers, TA1
Heitzman, JA1
Krebsbach, AM1
Aufdembrink, LM1
Hughes, R1
Bartolomucci, A1
Townsend, D1
Poletto Bonetto, JH1
Fernandes, RO1
Dartora, DR1
Flahault, A1
Sonea, A1
He, Y1
Cloutier, A1
Belló-Klein, A1
Nuyt, AM1
Liu, Q1
Lu, D1
Wang, S1
Wang, K1
Zhang, Q1
Wang, Y1
Fang, P1
Li, Z1
Geng, J1
Shan, Q1
Matsuhisa, S1
Otani, H1
Okazaki, T1
Yamashita, K1
Akita, Y1
Sato, D1
Moriguchi, A1
Iwasaka, T2
De Mello, WC3
Gerena, Y1
Arozal, W1
Watanabe, K2
Veeraveedu, PT1
Ma, M2
Thandavarayan, RA1
Suzuki, K1
Tachikawa, H1
Kodama, M2
Aizawa, Y2
Spurney, CF1
Sali, A1
Guerron, AD1
Iantorno, M1
Yu, Q1
Gordish-Dressman, H1
Rayavarapu, S1
van der Meulen, J1
Hoffman, EP1
Nagaraju, K1
Worou, ME1
Belmokhtar, K1
Bonnet, P1
Vourc'h, P1
Machet, MC1
Khamis, G1
Eder, V1
De Marco, M1
Gerdts, E1
Casalnuovo, G1
Migliore, T1
Wachtell, K1
Boman, K1
Dahlöf, B1
Olsen, MH1
Kizer, JR1
Devereux, RB1
de Simone, G1
Shibasaki, Y1
Nishiue, T1
Masaki, H1
Matsubara, H1
Peng, J1
Gurantz, D1
Tran, V1
Cowling, RT1
Greenberg, BH1
Monterrubio, J1
Goel, NK1
McBane, RD1
Kamath, PS1
Escobales, N2
Crespo, MJ4
Altieri, PI1
Gurusamy, N1
Prakash, P1
Hirabayashi, K1
Zhang, S1
Muslin, AJ1
Simões, MV1
Marin-Neto, JA1
Romano, MM1
O'Connell, JL1
de Santi, GL1
Maciel, BC1
Lambert, C1
Massillon, Y1
Meloche, S1
Nicoletti, A1
Heudes, D1
Hinglais, N1
Appay, MD1
Philippe, M1
Sassy-Prigent, C1
Bariety, J1
Michel, JB1
Dixon, IM1
Ju, H1
Reid, NL1
Scammell-La Fleur, T1
Werner, JP1
Jasmin, G1
Varo, N1
Etayo, JC1
Zalba, G1
Beaumont, J1
Iraburu, MJ1
Montiel, C1
Gil, MJ1
Monreal, I1
Díez, J1
Oldenburg, O1
Schäfers, RF1
Kuntz, S1
Sack, S1
Erbel, R1
Philipp, T1
Weber, F1

Reviews

2 reviews available for losartan and Cardiomyopathies

ArticleYear
Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy and X-linked dilated cardiomyopathy.
    The Cochrane database of systematic reviews, 2018, Oct-16, Volume: 10

    Topics: Adolescent; Adult; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antih

2018
Cardiac sarcoidosis: Case presentation and Review of the literature.
    Romanian journal of internal medicine = Revue roumaine de medecine interne, 2019, Mar-01, Volume: 57, Issue:1

    Topics: Cardiomyopathies; Cardiovascular Agents; Drug Therapy, Combination; Female; Humans; Immunosuppressiv

2019

Trials

1 trial available for losartan and Cardiomyopathies

ArticleYear
[Angiotensin II type 1 antagonist suppress left ventricular hypertrophy and myocardial fibrosis in patient with end stage renal disease (ESRD)].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60, Issue:10

    Topics: Amlodipine; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Calcium Chan

2002

Other Studies

29 other studies available for losartan and Cardiomyopathies

ArticleYear
Comparison of the antiremodeling effects of losartan and mirabegron in a rat model of uremic cardiomyopathy.
    Scientific reports, 2021, 09-01, Volume: 11, Issue:1

    Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Animals; Antihypertensive Agents; Cardiomyopathie

2021
Loeys-Dietz Cardiomyopathy? Long-term Follow-up After Onset of Acute Decompensated Heart Failure.
    The Canadian journal of cardiology, 2022, Volume: 38, Issue:3

    Topics: Acute Disease; Bisoprolol; Cardiomegaly; Cardiomyopathies; Cardiovascular Agents; Echocardiography;

2022
Investigation of the Antiremodeling Effects of Losartan, Mirabegron and Their Combination on the Development of Doxorubicin-Induced Chronic Cardiotoxicity in a Rat Model.
    International journal of molecular sciences, 2022, Feb-16, Volume: 23, Issue:4

    Topics: Acetanilides; Animals; Cardiomyopathies; Cardiotoxicity; Doxorubicin; Losartan; Male; Rats; Rats, Wi

2022
Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-κB and MAPK signaling.
    Pharmacological research, 2022, Volume: 185

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotens

2022
Integrin subunit β-like 1 mediates angiotensin II-induced myocardial fibrosis by regulating the forkhead box Q1/Snail axis.
    Archives of biochemistry and biophysics, 2022, 11-15, Volume: 730

    Topics: Angiotensin II; Animals; Cardiomyopathies; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Int

2022
An organ-on-a-chip model for pre-clinical drug evaluation in progressive non-genetic cardiomyopathy.
    Journal of molecular and cellular cardiology, 2021, Volume: 160

    Topics: Angiotensin II; Animals; Cardiomyopathies; Cardiotonic Agents; Cell Line; Cell Survival; Coculture T

2021
Acute AT
    Journal of molecular and cellular cardiology, 2019, Volume: 128

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Cardiomyopathies; Dystrophin; Heart; Humans; Isopr

2019
Impact of early life AT
    European journal of pharmacology, 2019, Oct-05, Volume: 860

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Biomarkers; Cardiomyopathies; Di

2019
Renal denervation significantly attenuates cardiorenal fibrosis in rats with sustained pressure overload.
    Journal of the American Society of Hypertension : JASH, 2016, Volume: 10, Issue:7

    Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biomarkers; Cardiomyo

2016
N-acetylcysteine abolishes the protective effect of losartan against left ventricular remodeling in cardiomyopathy hamster.
    Antioxidants & redox signaling, 2008, Volume: 10, Issue:12

    Topics: Acetylcysteine; Amidines; Angiotensin II Type 1 Receptor Blockers; Animals; Benzylamines; Cardiomyop

2008
Prolonged exposure of cardiac cells to renin plus angiotensinogen reduces intracellular renin in the failing heart. On the role of angiotensin II-AT1 complex internalization.
    Regulatory peptides, 2009, Jun-05, Volume: 155, Issue:1-3

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Cardiomyopathies; Cells, Cultured

2009
Effects of angiotensin receptor blocker on oxidative stress and cardio-renal function in streptozotocin-induced diabetic rats.
    Biological & pharmaceutical bulletin, 2009, Volume: 32, Issue:8

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blood Urea Nitrogen; Blotting, Western; Cardiomyop

2009
Losartan decreases cardiac muscle fibrosis and improves cardiac function in dystrophin-deficient mdx mice.
    Journal of cardiovascular pharmacology and therapeutics, 2011, Volume: 16, Issue:1

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cardiomyopathies; Cell Adhesion Mo

2011
Hemin decreases cardiac oxidative stress and fibrosis in a rat model of systemic hypertension via PI3K/Akt signalling.
    Cardiovascular research, 2011, Jul-15, Volume: 91, Issue:2

    Topics: Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, New

2011
Mitral annular calcification and incident ischemic stroke in treated hypertensive patients: the LIFE study.
    American journal of hypertension, 2013, Volume: 26, Issue:4

    Topics: Aged; Aged, 80 and over; Calcinosis; Cardiomyopathies; Echocardiography; Female; Humans; Hypertensio

2013
Tumor necrosis factor-alpha-induced AT1 receptor upregulation enhances angiotensin II-mediated cardiac fibroblast responses that favor fibrosis.
    Circulation research, 2002, Dec-13, Volume: 91, Issue:12

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Cardiomyopathies; Cells

2002
Intracellular and extracellular angiotensin II enhance the L-type calcium current in the failing heart.
    Hypertension (Dallas, Tex. : 1979), 2004, Volume: 44, Issue:3

    Topics: Adenosine Triphosphatases; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; A

2004
Cardiomyopathy associated with celiac disease.
    Mayo Clinic proceedings, 2005, Volume: 80, Issue:5

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Cardiomyopathies; Celiac Disease; Contraindications;

2005
Angiotensin II-dependent vascular alterations in young cardiomyopathic hamsters: role for oxidative stress.
    Vascular pharmacology, 2006, Volume: 44, Issue:1

    Topics: Acetylcysteine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Aort

2006
Increased vascular angiotensin II binding capacity and ET-1 release in young cardiomyopathic hamsters.
    Vascular pharmacology, 2006, Volume: 44, Issue:4

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Binding, Competit

2006
Glycogen synthase kinase 3beta together with 14-3-3 protein regulates diabetic cardiomyopathy: effect of losartan and tempol.
    FEBS letters, 2006, Apr-03, Volume: 580, Issue:8

    Topics: 14-3-3 Proteins; Angiotensin II; Animals; Apoptosis; Blood Glucose; Body Weight; Cardiomegaly; Cardi

2006
Transient left ventricular dysfunction due to stress-induced cardiomyopathy.
    Arquivos brasileiros de cardiologia, 2007, Volume: 89, Issue:4

    Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Aged; Angiotensin II Type 1 Receptor Blockers;

2007
Upregulation of cardiac angiotensin II AT1 receptors in congenital cardiomyopathic hamsters.
    Circulation research, 1995, Volume: 77, Issue:5

    Topics: Analysis of Variance; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Cardiomy

1995
Left ventricular fibrosis in renovascular hypertensive rats. Effect of losartan and spironolactone.
    Hypertension (Dallas, Tex. : 1979), 1995, Volume: 26, Issue:1

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biochemical Phen

1995
Cardiac collagen remodeling in the cardiomyopathic Syrian hamster and the effect of losartan.
    Journal of molecular and cellular cardiology, 1997, Volume: 29, Issue:7

    Topics: Animals; Biphenyl Compounds; Cardiomyopathies; Collagen; Collagenases; Cricetinae; Gelatinases; Gene

1997
Losartan inhibits the post-transcriptional synthesis of collagen type I and reverses left ventricular fibrosis in spontaneously hypertensive rats.
    Journal of hypertension, 1999, Volume: 17, Issue:1

    Topics: Animals; Antihypertensive Agents; Biomarkers; Blood Pressure; Blotting, Northern; Cardiomyopathies;

1999
[Heart failure as a cardiac symptom of sarcoidosis. Successful treatment of heart failure with steroids, digitalis and an angiotensin-1-receptor antagonist in sarcoidosis].
    Medizinische Klinik (Munich, Germany : 1983), 2000, Mar-15, Volume: 95, Issue:3

    Topics: Adult; Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Cardiomyopathies; Digitoxin; Drug Therapy,

2000
Interaction between AT1 and alpha1-adrenergic receptors in cardiomyopathic hamsters.
    Journal of cardiac failure, 2000, Volume: 6, Issue:3

    Topics: Angiotensin I; Animals; Antihypertensive Agents; Aorta; Cardiomyopathies; Cricetinae; Disease Models

2000
Chronic administration of losartan plus hydrochlorothiazide improves vascular status in young cardiomyopathic hamsters.
    European journal of pharmacology, 2001, May-25, Volume: 420, Issue:2-3

    Topics: Acetylcholine; Animals; Antihypertensive Agents; Aorta, Thoracic; Body Weight; Cardiomyopathies; Cri

2001