losartan has been researched along with Cardiac Output, Low in 19 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Cardiac Output, Low: A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Short-term add-on therapy with losartan reduced B-type natriuretic peptide levels in patients hospitalized for decompensated severe heart failure and low cardiac output with inotrope dependence." | 5.19 | Short-term add-on therapy with angiotensin receptor blocker for end-stage inotrope-dependent heart failure patients: B-type natriuretic peptide reduction in a randomized clinical trial. ( Barretto, AC; Brancalhão, EC; Cardoso, JN; Ochiai, ME; Oliveira, MT; Puig, RS; Vieira, KR, 2014) |
| " The angiotensin II receptors antagonists, of which Losartan will be the first representative on the Belgian market, constitute a new therapeutic class in the treatment of hypertension and even heart failure." | 4.79 | [The advent of a new class of antihypertensive agents: angiotensin II receptor antagonists]. ( Lefebvre, P, 1997) |
| "Losartan treatment was well tolerated in terms of adverse events, heart rate, and blood pressure response, and there were no significant changes in serum creatinine or potassium." | 2.69 | Combined treatment with losartan and an ACE inhibitor in mild to moderate heart failure: results of a double-blind, randomized, placebo-controlled trial. ( Cowley, AJ; Hampton, JR; Harrison, M; Houghton, AR, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (47.37) | 18.2507 |
| 2000's | 9 (47.37) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ochiai, ME | 1 |
| Brancalhão, EC | 1 |
| Puig, RS | 1 |
| Vieira, KR | 1 |
| Cardoso, JN | 1 |
| Oliveira, MT | 1 |
| Barretto, AC | 1 |
| Ushkvarok, LB | 1 |
| Rademaker, MT | 3 |
| Charles, CJ | 3 |
| Espiner, EA | 3 |
| Frampton, CM | 2 |
| Nicholls, MG | 2 |
| Richards, AM | 2 |
| Ahmed, MS | 1 |
| Øie, E | 1 |
| Vinge, LE | 1 |
| Yndestad, A | 1 |
| Øystein Andersen, G | 1 |
| Andersson, Y | 1 |
| Attramadal, T | 1 |
| Attramadal, H | 1 |
| Zhu, GQ | 1 |
| Gao, L | 2 |
| Patel, KP | 2 |
| Zucker, IH | 3 |
| Wang, W | 2 |
| Schultz, HD | 1 |
| Fitzpatrick, MA | 2 |
| Rush, JE | 1 |
| Rajfer, SI | 1 |
| Willenheimer, R | 1 |
| Cline, C | 1 |
| Erhardt, L | 1 |
| Lefebvre, P | 1 |
| Liu, JL | 1 |
| Squire, IB | 1 |
| Robb, S | 1 |
| Brennan, G | 1 |
| O'Kane, KP | 1 |
| Dargie, HJ | 1 |
| Reid, JL | 1 |
| Missouris, CG | 1 |
| Patel, SJ | 1 |
| Morton, JJ | 1 |
| MacGregor, GA | 1 |
| Cohen-Solal, A | 1 |
| Houghton, AR | 1 |
| Harrison, M | 1 |
| Cowley, AJ | 1 |
| Hampton, JR | 1 |
| Weinberg, EO | 1 |
| Herzig, JW | 1 |
| Xiu, JC | 1 |
| Wu, P | 1 |
| Xu, JP | 1 |
| Guo, Z | 1 |
| Lai, W | 1 |
| Zhang, Y | 1 |
| Li, S | 1 |
| Li, J | 1 |
| Liu, Y | 1 |
| Yandle, TG | 1 |
| Ikram, H | 1 |
| Raya, TE | 1 |
| Fonken, SJ | 1 |
| Lee, RW | 1 |
| Daugherty, S | 1 |
| Goldman, S | 1 |
| Wong, PC | 1 |
| Timmermans, PB | 1 |
| Morkin, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Short-term add-on Therapy With Angiotensin Receptor Blocker for End-stage Inotrope-dependent Heart Failure Patients: B-type Natriuretic Peptide Reduction in a Randomized Clinical Trial[NCT01857999] | Phase 4 | 21 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for losartan and Cardiac Output, Low
| Article | Year |
|---|---|
Theoretical basis for the use of angiotensin II antagonists in the treatment of heart failure.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Compounds; Cardiac Output, Low; H | 1993 |
[The advent of a new class of antihypertensive agents: angiotensin II receptor antagonists].
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Ben | 1997 |
Management of hypertension and heart failure with AT1 receptor blockade.
Topics: Aged; Angiotensin Receptor Antagonists; Antihypertensive Agents; Cardiac Output, Low; Clinical Trial | 2001 |
4 trials available for losartan and Cardiac Output, Low
| Article | Year |
|---|---|
Short-term add-on therapy with angiotensin receptor blocker for end-stage inotrope-dependent heart failure patients: B-type natriuretic peptide reduction in a randomized clinical trial.
Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Cardiac Outp | 2014 |
Combined inhibition of angiotensin II and endothelin suppresses the brain natriuretic peptide response to developing heart failure.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anti-Arrhythmia Agents; Antihypertensive | 2004 |
Blood pressure and renin angiotensin system responses to initiation of treatment with captopril or losartan in heart failure.
Topics: Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Blood Pre | 1999 |
Combined treatment with losartan and an ACE inhibitor in mild to moderate heart failure: results of a double-blind, randomized, placebo-controlled trial.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Cardiac Out | 2000 |
12 other studies available for losartan and Cardiac Output, Low
| Article | Year |
|---|---|
[Stability of neurohumoral effects of losartan combined with metoprolol in chronic cardiac low output].
Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Cardiac Output, Low; Chronic Disease; | 2002 |
Connective tissue growth factor--a novel mediator of angiotensin II-stimulated cardiac fibroblast activation in heart failure in rats.
Topics: Administration, Oral; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Arrhyth | 2004 |
ANG II in the paraventricular nucleus potentiates the cardiac sympathetic afferent reflex in rats with heart failure.
Topics: Angiotensin II; Animals; Arteries; Cardiac Output, Low; Chronic Disease; Coronary Vessels; Dose-Resp | 2004 |
Augmented input from cardiac sympathetic afferents inhibits baroreflex in rats with heart failure.
Topics: Animals; Antihypertensive Agents; Arteries; Baroreflex; Capsaicin; Cardiac Output, Low; Chronic Dise | 2005 |
Central angiotensin II AT1-receptor antagonism in normal and heart-failed sheep.
Topics: Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Brain; Cardiac Output, Low; Cardiac P | 1995 |
Combined heart failure treatment with ACE inhibition and AT1-receptor blockade.
Topics: Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Compounds | 1996 |
Regulation of sympathetic nerve activity in heart failure: a role for nitric oxide and angiotensin II.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output, Low; Cardiac Pacin | 1999 |
No acute additive effect of losartan in a patient already on an ACE inhibitor for heart failure.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Cardiac Output, Low; Dru | 1999 |
[Angiotensin II antagonists: a promising pathway].
Topics: Aged; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Ca | 2000 |
Effects of long-term enalapril and losartan therapy of heart failure on cardiovascular aldosterone.
Topics: Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiac Output, Low; | 2002 |
Angiotensin II receptor antagonism in ovine heart failure: acute hemodynamic, hormonal, and renal effects.
Topics: Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Captopril; Cardiac Output, Low; Femal | 1992 |
Hemodynamic effects of direct angiotensin II blockade compared to converting enzyme inhibition in rat model of heart failure.
Topics: Administration, Oral; Angiotensin II; Animals; Body Weight; Captopril; Cardiac Output, Low; Complian | 1991 |