losartan has been researched along with Brain Edema in 3 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We assessed the ability of poststroke losartan and captopril treatment to attenuate hematoma expansion and plasma extravasation after intracerebral hemorrhagic stroke in Kyoto-Wistar stroke-prone hypertensive rats (SHRsp)." | 7.88 | Post-stroke losartan and captopril treatments arrest hemorrhagic expansion in SHRsp without lowering blood pressure. ( Negandhi, A; Smeda, JS; Stuckless, J; Watson, D, 2018) |
| "Apparently, when hypertension is sustained, reappearance of target organ damage may not be entirely dependent on angiotensin." | 5.31 | Losartan versus enalapril on cerebral edema and proteinuria in stroke-prone hypertensive rats. ( Blezer, EL; Joles, JA; Koomans, HA; Nicolay, K, 2001) |
| "We assessed the ability of poststroke losartan and captopril treatment to attenuate hematoma expansion and plasma extravasation after intracerebral hemorrhagic stroke in Kyoto-Wistar stroke-prone hypertensive rats (SHRsp)." | 3.88 | Post-stroke losartan and captopril treatments arrest hemorrhagic expansion in SHRsp without lowering blood pressure. ( Negandhi, A; Smeda, JS; Stuckless, J; Watson, D, 2018) |
| "Apparently, when hypertension is sustained, reappearance of target organ damage may not be entirely dependent on angiotensin." | 1.31 | Losartan versus enalapril on cerebral edema and proteinuria in stroke-prone hypertensive rats. ( Blezer, EL; Joles, JA; Koomans, HA; Nicolay, K, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Smeda, JS | 1 |
| Watson, D | 1 |
| Stuckless, J | 1 |
| Negandhi, A | 1 |
| Asiedu-Gyekye, IJ | 1 |
| Antwi, DA | 1 |
| Blezer, EL | 1 |
| Nicolay, K | 1 |
| Koomans, HA | 1 |
| Joles, JA | 1 |
3 other studies available for losartan and Brain Edema
| Article | Year |
|---|---|
Post-stroke losartan and captopril treatments arrest hemorrhagic expansion in SHRsp without lowering blood pressure.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pr | 2018 |
Does losartan prevent cerebral edema? A preliminary study using a vascular compartment model.
Topics: Angiotensin Receptor Antagonists; Animals; Blood Proteins; Brain Edema; Capillary Permeability; Cats | 2003 |
Losartan versus enalapril on cerebral edema and proteinuria in stroke-prone hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Brain Edema; Drug Admini | 2001 |