losartan has been researched along with Beuren Syndrome in 2 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
| Excerpt | Relevance | Reference |
|---|---|---|
| "Increased arterial stiffness is a common characteristic of humans with Williams-Beuren syndrome and mouse models of elastin insufficiency." | 3.81 | Chronic antihypertensive treatment improves pulse pressure but not large artery mechanics in a mouse model of congenital vascular stiffness. ( Broekelmann, TJ; Halabi, CM; Knutsen, RH; Kozel, BA; Mecham, RP; Ye, L, 2015) |
| "67 Mb heterozygous deletion including the Eln gene, presented with a generalized arteriopathy, hypertension, and cardiac hypertrophy, associated with elevated angiotensin II (angII), oxidative stress parameters, and Ncf1 expression." | 3.78 | Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome. ( Bustelo, XR; Campuzano, V; Coustets, M; Francke, U; Menacho-Márquez, M; Nevado, J; Pérez-Jurado, LA; Sánchez-Rodríguez, C; Segura-Puimedon, M; Terrado, V, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Halabi, CM | 1 |
| Broekelmann, TJ | 1 |
| Knutsen, RH | 1 |
| Ye, L | 1 |
| Mecham, RP | 1 |
| Kozel, BA | 1 |
| Campuzano, V | 1 |
| Segura-Puimedon, M | 1 |
| Terrado, V | 1 |
| Sánchez-Rodríguez, C | 1 |
| Coustets, M | 1 |
| Menacho-Márquez, M | 1 |
| Nevado, J | 1 |
| Bustelo, XR | 1 |
| Francke, U | 1 |
| Pérez-Jurado, LA | 1 |
2 other studies available for losartan and Beuren Syndrome
| Article | Year |
|---|---|
Chronic antihypertensive treatment improves pulse pressure but not large artery mechanics in a mouse model of congenital vascular stiffness.
Topics: Animals; Antihypertensive Agents; Arteries; Blood Pressure; Elastin; Losartan; Mice; Mice, Inbred C5 | 2015 |
Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome.
Topics: Acetophenones; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arteries; Blood Pre | 2012 |