losartan has been researched along with Behcet Syndrome in 2 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Behcet Syndrome: Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.
| Excerpt | Relevance | Reference |
|---|---|---|
| " As this seems not to be due to colchicine treatment, our hypothesis is that inflammation related to BD might have caused the down-regulation of the CYP2C9 activity due to immune cytokine reactions." | 3.81 | Lower CYP2C9 activity in Turkish patients with Behçet's disease compared to healthy subjects: a down-regulation due to inflammation? ( Akdogan, A; Babaoglu, MO; Bertilsson, L; Bozkurt, A; Goktaş, MT; Hatta, F; Helldén, A; Kalkisim, S; Karaca, O; Kilic, L; Yasar, U, 2015) |
| " When fluconazole, a potent inhibitor of CYP2C9, was added to the treatment regimen, the patient developed ataxia, tremor, fatigue, slurred speech and somnolence, indicating phenytoin intoxication." | 3.76 | Fluconazole-induced intoxication with phenytoin in a patient with ultra-high activity of CYP2C9. ( Bergman, U; Bertilsson, L; Engström Hellgren, K; Helldén, A; Masquelier, M; Nilsson Remahl, I; Odar-Cederlöf, I; Ramsjö, M, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goktaş, MT | 1 |
| Hatta, F | 1 |
| Karaca, O | 1 |
| Kalkisim, S | 1 |
| Kilic, L | 1 |
| Akdogan, A | 1 |
| Babaoglu, MO | 1 |
| Bozkurt, A | 1 |
| Helldén, A | 2 |
| Bertilsson, L | 2 |
| Yasar, U | 1 |
| Bergman, U | 1 |
| Engström Hellgren, K | 1 |
| Masquelier, M | 1 |
| Nilsson Remahl, I | 1 |
| Odar-Cederlöf, I | 1 |
| Ramsjö, M | 1 |
2 other studies available for losartan and Behcet Syndrome
| Article | Year |
|---|---|
Lower CYP2C9 activity in Turkish patients with Behçet's disease compared to healthy subjects: a down-regulation due to inflammation?
Topics: Adult; Aged; Alleles; Behcet Syndrome; Chromatography, High Pressure Liquid; Colchicine; Cytochrome | 2015 |
Fluconazole-induced intoxication with phenytoin in a patient with ultra-high activity of CYP2C9.
Topics: Alleles; Angiotensin II Type 1 Receptor Blockers; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; At | 2010 |