losartan has been researched along with Aortic Dissection in 10 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
| Excerpt | Relevance | Reference |
|---|---|---|
| "The COMPARE trial showed a small but significant beneficial effect of 3-year losartan treatment on aortic root dilatation rate in adults with Marfan syndrome (MFS)." | 9.34 | Long-term clinical outcomes of losartan in patients with Marfan syndrome: follow-up of the multicentre randomized controlled COMPARE trial. ( Balm, R; de Waard, V; Groenink, M; Indrakusuma, R; Jalalzadeh, H; Mulder, BJM; Scholte, AJ; Timmermans, J; van Andel, MM; van den Berg, MP; Zwinderman, AH, 2020) |
| "Long-term outcome of Marfan syndrome patients randomly assigned to losartan or atenolol showed no differences in aortic dilation rate or presence of clinical events between treatment groups." | 9.27 | Losartan Versus Atenolol for Prevention of Aortic Dilation in Patients With Marfan Syndrome. ( Evangelista, A; Forteza, A; García-Dorado, D; González Mirelis, J; Gutiérrez, L; Ibáñez, B; Rodríguez-Palomares, J; Sánchez, V; Teixido-Tura, G, 2018) |
| "Treatment with losartan will be compared with no additional treatment after 3 years of follow-up." | 6.75 | Losartan therapy in adults with Marfan syndrome: study protocol of the multi-center randomized controlled COMPARE trial. ( Baars, MJ; de Witte, P; Groenink, M; Mulder, BJ; Radonic, T; Zwinderman, AH, 2010) |
| "The COMPARE trial showed a small but significant beneficial effect of 3-year losartan treatment on aortic root dilatation rate in adults with Marfan syndrome (MFS)." | 5.34 | Long-term clinical outcomes of losartan in patients with Marfan syndrome: follow-up of the multicentre randomized controlled COMPARE trial. ( Balm, R; de Waard, V; Groenink, M; Indrakusuma, R; Jalalzadeh, H; Mulder, BJM; Scholte, AJ; Timmermans, J; van Andel, MM; van den Berg, MP; Zwinderman, AH, 2020) |
| "Long-term outcome of Marfan syndrome patients randomly assigned to losartan or atenolol showed no differences in aortic dilation rate or presence of clinical events between treatment groups." | 5.27 | Losartan Versus Atenolol for Prevention of Aortic Dilation in Patients With Marfan Syndrome. ( Evangelista, A; Forteza, A; García-Dorado, D; González Mirelis, J; Gutiérrez, L; Ibáñez, B; Rodríguez-Palomares, J; Sánchez, V; Teixido-Tura, G, 2018) |
| "To test the hypothesis that angiotensin II (Ang II) could enhance noradrenaline (NA) release from sympathetic nerve endings of the aorta thus contributing to the up-regulation of matrix metalloproteinase 2 (MMP-2) during the formation of aortic dissection (AD)." | 3.79 | Ang II enhances noradrenaline release from sympathetic nerve endings thus contributing to the up-regulation of metalloprotease-2 in aortic dissection patients' aorta wall. ( Hu, X; Hu, Z; Jiang, W; Li, L; Wang, Z; Wu, H; Yang, Z, 2013) |
| "Treatment with losartan will be compared with no additional treatment after 3 years of follow-up." | 2.75 | Losartan therapy in adults with Marfan syndrome: study protocol of the multi-center randomized controlled COMPARE trial. ( Baars, MJ; de Witte, P; Groenink, M; Mulder, BJ; Radonic, T; Zwinderman, AH, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (70.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, Y | 1 |
| Asano, K | 1 |
| Sedes, L | 1 |
| Cantalupo, A | 1 |
| Hansen, J | 1 |
| Iyengar, R | 1 |
| Walsh, MJ | 1 |
| Ramirez, F | 3 |
| van Andel, MM | 1 |
| Indrakusuma, R | 1 |
| Jalalzadeh, H | 1 |
| Balm, R | 1 |
| Timmermans, J | 2 |
| Scholte, AJ | 2 |
| van den Berg, MP | 2 |
| Zwinderman, AH | 3 |
| Mulder, BJM | 1 |
| de Waard, V | 2 |
| Groenink, M | 3 |
| Sellers, SL | 1 |
| Milad, N | 1 |
| Chan, R | 1 |
| Mielnik, M | 1 |
| Jermilova, U | 1 |
| Huang, PL | 1 |
| de Crom, R | 1 |
| Hirota, JA | 1 |
| Hogg, JC | 1 |
| Sandor, GG | 1 |
| Van Breemen, C | 1 |
| Esfandiarei, M | 1 |
| Seidman, MA | 1 |
| Bernatchez, P | 1 |
| Teixido-Tura, G | 1 |
| Forteza, A | 1 |
| Rodríguez-Palomares, J | 1 |
| González Mirelis, J | 1 |
| Gutiérrez, L | 1 |
| Sánchez, V | 1 |
| Ibáñez, B | 1 |
| García-Dorado, D | 1 |
| Evangelista, A | 1 |
| Milewicz, DM | 2 |
| Dubacher, N | 1 |
| Münger, J | 1 |
| Gorosabel, MC | 1 |
| Crabb, J | 1 |
| Ksiazek, AA | 1 |
| Caspar, SM | 1 |
| Bakker, ENTP | 1 |
| van Bavel, E | 1 |
| Ziegler, U | 1 |
| Carrel, T | 1 |
| Steinmann, B | 1 |
| Zeisberger, S | 1 |
| Meienberg, J | 1 |
| Matyas, G | 1 |
| Hu, Z | 1 |
| Wang, Z | 1 |
| Wu, H | 1 |
| Yang, Z | 1 |
| Jiang, W | 1 |
| Li, L | 1 |
| Hu, X | 1 |
| Franken, R | 1 |
| El Morabit, A | 1 |
| Marquering, H | 1 |
| Planken, NR | 1 |
| Mulder, BJ | 2 |
| Prakash, SK | 1 |
| Radonic, T | 1 |
| de Witte, P | 1 |
| Baars, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter Randomized Controlled Trial of Exercise in Aortic Dissection Survivors[NCT05610462] | 126 participants (Anticipated) | Interventional | 2023-01-01 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for losartan and Aortic Dissection
| Article | Year |
|---|---|
Therapies for Thoracic Aortic Aneurysms and Acute Aortic Dissections.
Topics: Acute Disease; Angiotensin II; Animals; Aortic Aneurysm, Thoracic; Aortic Dissection; Humans; Losart | 2019 |
Therapeutics Targeting Drivers of Thoracic Aortic Aneurysms and Acute Aortic Dissections: Insights from Predisposing Genes and Mouse Models.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aortic Aneurysm, Thoracic; Aortic Dissection; Dise | 2017 |
4 trials available for losartan and Aortic Dissection
| Article | Year |
|---|---|
Long-term clinical outcomes of losartan in patients with Marfan syndrome: follow-up of the multicentre randomized controlled COMPARE trial.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Aortic Dissection; Follow-Up Studies; Humans; Losart | 2020 |
Losartan Versus Atenolol for Prevention of Aortic Dilation in Patients With Marfan Syndrome.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Angiotensin II Type 1 Receptor Blockers; Aorta; Aorti | 2018 |
Increased aortic tortuosity indicates a more severe aortic phenotype in adults with Marfan syndrome.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Aorta; Aortic Diseases; Aortic Dissection; Dilatatio | 2015 |
Losartan therapy in adults with Marfan syndrome: study protocol of the multi-center randomized controlled COMPARE trial.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Aortic Aneurysm; Aortic Dissection; Biopsy; Echocard | 2010 |
4 other studies available for losartan and Aortic Dissection
| Article | Year |
|---|---|
Dissecting aortic aneurysm in Marfan syndrome is associated with losartan-sensitive transcriptomic modulation of aortic cells.
Topics: Animals; Aorta; Aortic Aneurysm; Aortic Aneurysm, Thoracic; Aortic Dissection; Humans; Losartan; Mar | 2023 |
Inhibition of Marfan Syndrome Aortic Root Dilation by Losartan: Role of Angiotensin II Receptor Type 1-Independent Activation of Endothelial Function.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aortic Dissection; Blood | 2018 |
Celiprolol but not losartan improves the biomechanical integrity of the aorta in a mouse model of vascular Ehlers-Danlos syndrome.
Topics: Adrenergic beta-1 Receptor Antagonists; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Tho | 2020 |
Ang II enhances noradrenaline release from sympathetic nerve endings thus contributing to the up-regulation of metalloprotease-2 in aortic dissection patients' aorta wall.
Topics: Adrenergic Fibers; Angiotensin II; Animals; Aorta; Aortic Dissection; Chromatography, High Pressure | 2013 |