losartan has been researched along with Aortic Coarctation in 11 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Aortic Coarctation: A birth defect characterized by the narrowing of the AORTA that can be of varying degree and at any point from the transverse arch to the iliac bifurcation. Aortic coarctation causes arterial HYPERTENSION before the point of narrowing and arterial HYPOTENSION beyond the narrowed portion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In pregnancy there is an attenuated response to vasoconstrictors and pressor agents, including Angiotensin II (Ang II)." | 3.73 | Renal vascular responses in an experimental model of preeclampsia. ( Bobadilla Lugo, RA; López Sanchez, P; Pérez-Alvarez, VM; Robledo, LA, 2005) |
| "To assess the role of angiotensin (ANG) II in both the increased heart rate (HR) and the impaired baroreceptor reflex control of HR that characterize the chronic phase of coarctation hypertension (CH), we compared basal HR, mean arterial pressure (MAP), and baroreflex sensitivity of coarcted hypertensive rats treated chronically with losartan, captopril, or vehicle." | 3.69 | Losartan improves baroreflex control of heart rate of coarcted hypertensive rats. ( Leomil Neto, M; Michelini, LC; Pontieri, V; Santos, CM, 1995) |
| "The role of angiotensin II via the angiotensin type 1 or type 2 receptor in the development of cardiac hypertrophy was determined in adult male Sprague-Dawley rats subjected to coarctation of the abdominal aorta." | 3.69 | Angiotensin receptor regulates cardiac hypertrophy and transforming growth factor-beta 1 expression. ( Everett, AD; Fisher, A; Gomez, RA; Tufro-McReddie, A, 1994) |
| " NG-Nitro-L-arginine methyl ester (L-NAME) (3 x 10(-4) mol/L) increased tension (82 +/- 11% of the response to 120 mmol/L potassium chloride) in rings of thoracic aorta taken from hypertensive rats 7 to 14 days after aortic coarctation, whereas rings of abdominal aorta from below the coarctation were unresponsive, as were rings of thoracic aorta from rats with deoxycorticosterone-salt-induced hypertension and from the corresponding normotensive controls of either model of hypertension." | 3.69 | Vascular responsiveness to nitric oxide synthesis inhibition in hypertensive rats. ( Dick, LB; Guan, H; Lin, L; Miller, KB; Nasjletti, A; Pucci, ML, 1994) |
| " Pretreatment with NG-nitro-L-arginine methyl ester did not interfere with the vasodepressor effect of sodium nitroprusside or prazosin in rats with aortic coarctation-induced hypertension or with the blood pressure reduction caused by discontinuation of an infusion of phenylephrine in rats made hypertensive by long-term administration of this drug." | 1.29 | Nitric oxide and the depressor response to angiotensin blockade in hypertension. ( Cachofeiro, V; Guan, H; Kaminski, PM; Nasjletti, A; Pucci, ML; Wolin, MS, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Volkova, NI | 1 |
| Lazoryshynets, VV | 1 |
| López, RM | 1 |
| Castillo, MC | 1 |
| López, JS | 1 |
| Guevara, G | 1 |
| López, P | 1 |
| Castillo, EF | 1 |
| Zhu, GQ | 1 |
| Xu, Y | 1 |
| Zhou, LM | 1 |
| Li, YH | 1 |
| Fan, LM | 1 |
| Wang, W | 1 |
| Gao, XY | 1 |
| Chen, Q | 1 |
| Li, D | 1 |
| Scott, L | 1 |
| Crambert, S | 1 |
| Zelenin, S | 1 |
| Eklöf, AC | 1 |
| Di Ciano, L | 1 |
| Ibarra, F | 1 |
| Aperia, A | 1 |
| Bobadilla Lugo, RA | 1 |
| Pérez-Alvarez, VM | 1 |
| Robledo, LA | 1 |
| López Sanchez, P | 1 |
| Santos, CM | 1 |
| Pontieri, V | 1 |
| Leomil Neto, M | 1 |
| Michelini, LC | 1 |
| Everett, AD | 1 |
| Tufro-McReddie, A | 1 |
| Fisher, A | 1 |
| Gomez, RA | 1 |
| Pucci, ML | 2 |
| Miller, KB | 1 |
| Dick, LB | 1 |
| Guan, H | 2 |
| Lin, L | 1 |
| Nasjletti, A | 2 |
| Cachofeiro, V | 1 |
| Kaminski, PM | 1 |
| Wolin, MS | 1 |
| Ling, Q | 1 |
| Chen, TH | 1 |
| Guo, ZG | 1 |
| De Bruno, MP | 1 |
| Marañón, RO | 1 |
| Reynoso, HA | 1 |
| Coviello, A | 1 |
11 other studies available for losartan and Aortic Coarctation
| Article | Year |
|---|---|
[Microalbuminuria as a marker of endothelial dysfunction in the long-term follow-up patients after surgical correction of aortic coarctation].
Topics: Adolescent; Adult; Albuminuria; Antihypertensive Agents; Aorta, Thoracic; Aortic Coarctation; Biomar | 2013 |
Activation of upregulated angiotensin II type 2 receptors decreases carotid pulse pressure in rats with suprarenal abdominal aortic coarctation.
Topics: Angiotensin II Type 2 Receptor Blockers; Animals; Aortic Coarctation; Blood Pressure; Blotting, West | 2015 |
Enhanced cardiac sympathetic afferent reflex involved in sympathetic overactivity in renovascular hypertensive rats.
Topics: Angiotensin II; Animals; Aortic Coarctation; Hypertension, Renovascular; Injections, Intravenous; In | 2009 |
Binding of losartan to angiotensin AT1 receptors increases dopamine D1 receptor activation.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aortic Coarctation; Benzazepines; Cell Membrane; C | 2012 |
Renal vascular responses in an experimental model of preeclampsia.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aortic Coarctation; Blood Pressure | 2005 |
Losartan improves baroreflex control of heart rate of coarcted hypertensive rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Aortic Coarctation; Baroreflex; Biphenyl Com | 1995 |
Angiotensin receptor regulates cardiac hypertrophy and transforming growth factor-beta 1 expression.
Topics: Angiotensin II; Animals; Aortic Coarctation; Atrial Natriuretic Factor; Biphenyl Compounds; Cardiome | 1994 |
Vascular responsiveness to nitric oxide synthesis inhibition in hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Aortic Coarctation; Arginine; Biphenyl Compounds; | 1994 |
Nitric oxide and the depressor response to angiotensin blockade in hypertension.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aortic Coarctation; Arginine; Bip | 1996 |
Inhibition of beta-myosin heavy chain gene expression in pressure overload rat heart by losartan and captopril.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Aortic Coarctat | 1997 |
Structural changes in the kidney induced by coarctation hypertension.
Topics: Animals; Antihypertensive Agents; Aortic Coarctation; Body Weight; Disease Models, Animal; Heart Rat | 2001 |