Page last updated: 2024-10-30

losartan and Anxiety

losartan has been researched along with Anxiety in 9 studies

Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"The angiotensin II receptor antagonist, DUP 753 (Losartan), was compared with diazepam for antianxiety properties in the rat using the elevated plus-maze."7.68Antianxiety properties of the angiotensin II antagonist, DUP 753, in the rat using the elevated plus-maze. ( Carr, RD; Fraser-Rae, L; Hallam, C; Kaiser, FC; Palmer, GC; Wallace, AV, 1992)
"Losartan was unable to improve hippocampal BDNF and IL-10 levels as well as the retention trial in the MWM task and depressive-like behaviors."5.56Losartan modulates brain inflammation and improves mood disorders and memory impairment induced by innate immune activation: The role of PPAR-γ activation. ( Baghcheghi, Y; Hosseini, M; Mokhtari-Zaer, A; Moradi-Marjaneh, R; Salmani, H, 2020)
"The antihypertensive drug losartan has been shown to improve memory in humans as well as learning and fear extinction in rodent models, highlighting its potential to have similar synergistic effects on exposure-based cognitive behavioral therapy for anxiety disorders."5.27Angiotensin Regulation of Amygdala Response to Threat in High-Trait-Anxiety Individuals. ( Browning, M; Craske, MG; Harmer, CJ; Kappelmann, N; Klein Breteler, J; Reinecke, A; Ressler, KJ, 2018)
"5μg) did not change the anxiety-like behavior of OBX rats, while losartan (100μg) showed an anxiolytic-like behavior, by increasing the number and time of open arms entries, the ratio of open/total entries and open/total time and decreasing the number and time of closed arm entries."3.88Involvement of hippocampal angiotensin 1 receptors in anxiety-like behaviour of olfactory bulbectomized rats. ( Ivanova, M; Tashev, R, 2018)
"The angiotensin II receptor antagonist, DUP 753 (Losartan), was compared with diazepam for antianxiety properties in the rat using the elevated plus-maze."3.68Antianxiety properties of the angiotensin II antagonist, DUP 753, in the rat using the elevated plus-maze. ( Carr, RD; Fraser-Rae, L; Hallam, C; Kaiser, FC; Palmer, GC; Wallace, AV, 1992)
"Losartan was unable to improve hippocampal BDNF and IL-10 levels as well as the retention trial in the MWM task and depressive-like behaviors."1.56Losartan modulates brain inflammation and improves mood disorders and memory impairment induced by innate immune activation: The role of PPAR-γ activation. ( Baghcheghi, Y; Hosseini, M; Mokhtari-Zaer, A; Moradi-Marjaneh, R; Salmani, H, 2020)
"Renal hypertension was induced in Wistar strain male albino rats weighing 200-250 g by following the method of Goldblatt."1.32Differential anxiolytic effect of enalapril and losartan in normotensive and renal hypertensive rats. ( Ramanathan, M; Srinivasan, J; Suresh, B, 2003)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's2 (22.22)29.6817
2010's4 (44.44)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Salmani, H1
Hosseini, M1
Baghcheghi, Y1
Moradi-Marjaneh, R1
Mokhtari-Zaer, A1
Genaro, K1
Fabris, D1
Fachim, HA1
Prado, WA1
Reinecke, A1
Browning, M1
Klein Breteler, J1
Kappelmann, N1
Ressler, KJ1
Harmer, CJ1
Craske, MG1
Tashev, R1
Ivanova, M1
Llano López, LH1
Caif, F1
García, S1
Fraile, M1
Landa, AI1
Baiardi, G1
Lafuente, JV1
Braszko, JJ1
Bregonzio, C1
Gargiulo, PA1
Srinivasan, J1
Suresh, B1
Ramanathan, M1
Bonini, JS1
Bevilaqua, LR1
Zinn, CG1
Kerr, DS1
Medina, JH1
Izquierdo, I1
Cammarota, M1
Shepherd, J1
Bill, DJ1
Dourish, CT1
Grewal, SS1
McLenachan, A1
Stanhope, KJ1
Kaiser, FC1
Palmer, GC1
Wallace, AV1
Carr, RD1
Fraser-Rae, L1
Hallam, C1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Losartan on Emotional Processing in Healthy Volunteers[NCT03434054]30 participants (Actual)Interventional2016-06-01Completed
Enhancing Fear Extinction Via Angiotensin Type 1 Receptor Inhibition: A Randomized Controlled Trial in Posttraumatic Stress Disorder[NCT02709018]149 participants (Actual)Interventional2016-07-16Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in CAPS-5 Associated With CC Homozygosity for rs4311 SNP in the Angiotensin Converting Enzyme Gene (ACE) Compared to T Carriers, Among Subjects Randomized to Losartan.

The Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) as used here has 20 items, each scored 0-4, to yield a score with a possible range of 0-80. Higher scores mean worse outcome. (NCT02709018)
Timeframe: 10 weeks

Interventionscore on a scale (Mean)
CC Homozygotes on Losartan16.7
T Carriers on Losartan15.8

The Primary Outcome for This Study is Mean Change in Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) Over the Treatment Period of 10 Weeks Between the Losartan Arm and the Placebo Arm.

"Clinician-Administered PTSD Scale for DSM-5 also known as CAPS-5 is the gold standard in PTSD assessment. The CAPS-5 is a 30-item structured interview that can be used to, make current (past month) diagnosis of PTSD, make a lifetime diagnosis of PTSD and assess PTSD symptoms over the past week.~The CAPS-5 as used here has 20 items, each scored 0-4, to yield a score with a possible range of 0-80. Higher scores mean worse outcome." (NCT02709018)
Timeframe: 10 weeks

Interventionscore on a scale (Mean)
Losartan-15.96
Placebo-16.89

Trials

1 trial available for losartan and Anxiety

ArticleYear
Angiotensin Regulation of Amygdala Response to Threat in High-Trait-Anxiety Individuals.
    Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018, Volume: 3, Issue:10

    Topics: Adult; Amygdala; Angiotensins; Anxiety; Anxiety Disorders; Brain Mapping; Emotions; Facial Expressio

2018

Other Studies

8 other studies available for losartan and Anxiety

ArticleYear
Losartan modulates brain inflammation and improves mood disorders and memory impairment induced by innate immune activation: The role of PPAR-γ activation.
    Cytokine, 2020, Volume: 125

    Topics: Amyloid beta-Peptides; Angiotensin Receptor Antagonists; Anilides; Animals; Anxiety; Behavior Rating

2020
Angiotensin AT1 receptors modulate the anxiogenic effects of angiotensin (5-8) injected into the rat ventrolateral periaqueductal gray.
    Peptides, 2017, Volume: 96

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Anxiety; Imidazoles; Losartan; Mal

2017
Involvement of hippocampal angiotensin 1 receptors in anxiety-like behaviour of olfactory bulbectomized rats.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:5

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Anxiety; CA1 Region, Hippocampal;

2018
Anxiolytic-like effect of losartan injected into amygdala of the acutely stressed rats.
    Pharmacological reports : PR, 2012, Volume: 64, Issue:1

    Topics: Amygdala; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Anxiety Agents; Anxiety; Behavior,

2012
Differential anxiolytic effect of enalapril and losartan in normotensive and renal hypertensive rats.
    Physiology & behavior, 2003, Volume: 78, Issue:4-5

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Anx

2003
Angiotensin II disrupts inhibitory avoidance memory retrieval.
    Hormones and behavior, 2006, Volume: 50, Issue:2

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; An

2006
Effects of the selective angiotensin II receptor antagonists losartan and PD123177 in animal models of anxiety and memory.
    Psychopharmacology, 1996, Volume: 126, Issue:3

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anti-Anxiety Agents; Anxiety; Biphenyl Co

1996
Antianxiety properties of the angiotensin II antagonist, DUP 753, in the rat using the elevated plus-maze.
    Neuroreport, 1992, Volume: 3, Issue:10

    Topics: Angiotensin II; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Biphenyl Compounds; Blood P

1992