losartan has been researched along with Anxiety Neuroses in 3 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antihypertensive drug losartan has been shown to improve memory in humans as well as learning and fear extinction in rodent models, highlighting its potential to have similar synergistic effects on exposure-based cognitive behavioral therapy for anxiety disorders." | 5.27 | Angiotensin Regulation of Amygdala Response to Threat in High-Trait-Anxiety Individuals. ( Browning, M; Craske, MG; Harmer, CJ; Kappelmann, N; Klein Breteler, J; Reinecke, A; Ressler, KJ, 2018) |
| "In studies of dementias and Alzheimer's disease (AD), some studies have shown that antihypertensive drugs, including angiotensin-converting enzyme inhibitors, have some moderate effects on cognitive decline, but that the angiotensin receptor antagonist losartan has a significantly beneficial effect." | 2.42 | Angiotensin as a target for the treatment of Alzheimer's disease, anxiety and depression. ( Gard, PR, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Reinecke, A | 2 |
| Browning, M | 2 |
| Klein Breteler, J | 1 |
| Kappelmann, N | 1 |
| Ressler, KJ | 1 |
| Harmer, CJ | 1 |
| Craske, MG | 2 |
| Pulcu, E | 1 |
| Shkreli, L | 1 |
| Holst, CG | 1 |
| Woud, ML | 1 |
| Gard, PR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Losartan on Emotional Processing in Healthy Volunteers[NCT03434054] | 30 participants (Actual) | Interventional | 2016-06-01 | Completed | |||
| The Effect of Losartan on Emotional Memory in Healthy Volunteers[NCT03763409] | 53 participants (Actual) | Interventional | 2018-03-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for losartan and Anxiety Neuroses
| Article | Year |
|---|---|
Angiotensin as a target for the treatment of Alzheimer's disease, anxiety and depression.
Topics: Aging; Alzheimer Disease; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inh | 2004 |
2 trials available for losartan and Anxiety Neuroses
| Article | Year |
|---|---|
Angiotensin Regulation of Amygdala Response to Threat in High-Trait-Anxiety Individuals.
Topics: Adult; Amygdala; Angiotensins; Anxiety; Anxiety Disorders; Brain Mapping; Emotions; Facial Expressio | 2018 |
The Effects of the Angiotensin II Receptor Antagonist Losartan on Appetitive Versus Aversive Learning: A Randomized Controlled Trial.
Topics: Adult; Angiotensin Receptor Antagonists; Anxiety Disorders; Appetitive Behavior; Association Learnin | 2019 |