losartan and Ambulation Difficulty

losartan has been researched along with Ambulation Difficulty in 3 studies

Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position

Research

Studies (3)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Changes in the Interleukin-6 Level Between Groups

Changes in the Interleukin-6 Level Between the Groups (NCT02676466)
Timeframe: Changes from baseline to month 12

Isometric Hand Grip Strength

The purpose of this test is to measure the maximum isometric strength of the hand and forearm muscles. Scoring will be taken from the best results of 3 trials. Males scores range from 88 pounds as very poor to 141 pounds as excellent with an average of 105-113 pounds. Females scores range from 44 pounds as very poor to 84 pounds as excellent with an average of 57-65 pounds. (NCT02676466)
Timeframe: 12 months

Number of Participants Exhibiting Frailty

Frailty will be characterized with Fried criteria developed by Fried et al. that employ self-reported exhaustion, unintentional weight loss, low energy expenditure, slow gait speed, and weak grip strength. Those with >3 of the 5 factors are judged to be frail, those with 1 or 2 factors as pre-frail, and those with no factors as non-frail. (NCT02676466)
Timeframe: 12 months

Number of Participants Experiencing Major Mobility Disability

The 400 meter walk test at usual pace is used to evaluate major mobility disability (MMD), defined as the inability to walk ¼ mile or 400 meters. (NCT02676466)
Timeframe: 12 months

Peak Torque of the Knee Extensor and Flexor Muscles

Peak torque was measured at a rotational speed of 60 degrees per second using a commercially-available Isokinetic Dynamometer (Biodex). Torque was measured during maximal knee extension and flexion reported in Newton Meters. (NCT02676466)
Timeframe: month 12

Short Form Health Survey (SF-36) - Physical Component Score

The Short Form (36) Health Survey is a 36-item, patient-reported survey of patient health. The SF-36 consists of eight scaled scores, which are the weighted sums of the questions in their section. Range: 0-100. A lower score indicates more disability, i.e., a score of zero is equivalent to maximum disability and a score of 100 is equivalent to no disability. (NCT02676466)
Timeframe: month 12

Short Physical Performance Battery (SPPB)

A low score on the SPPB based on 4 m walk, balance & chair stands tests is a risk factor for disability, institutionalization, morbidity and mortality in initially non-disabled older persons. The summary score and components of the SPPB have good reliability (ICCs range from 0.88 to 0.92). Higher scores are better. Range 0-12. (NCT02676466)
Timeframe: 12 months

Trials

3 trials available for losartan and Ambulation Difficulty