losartan has been researched along with Alcohol Drinking in 9 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Alcohol Drinking: Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the Losartan Intervention For Endpoint reduction in Hypertension (LIFE) study, a double-blinded, randomized, parallel-group study, 9193 hypertensive patients with electrocardiogram (ECG)-documented left ventricular hypertrophy (LVH), randomized to once-daily losartan- or atenolol-based antihypertensive therapy were followed for a mean of 4." | 5.16 | Impact of alcohol habits and smoking on the risk of new-onset atrial fibrillation in hypertensive patients with ECG left ventricular hypertrophy: the LIFE study. ( Ariansen, I; Dahlöf, B; Devereux, RB; Gjesdal, K; Ibsen, H; Kjeldsen, SE; Okin, PM; Olsen, MH; Reims, HM; Wachtell, K, 2012) |
| "The Losartan Intervention For End point reduction in hypertension (LIFE) study showed superiority of losartan over atenolol for reduction of composite risk of cardiovascular death, stroke, and myocardial infarction in hypertensives with left ventricular hypertrophy." | 5.11 | Alcohol consumption and cardiovascular risk in hypertensives with left ventricular hypertrophy: the LIFE study. ( Beevers, G; Brady, WE; Dahlöf, B; De Faire, U; Devereux, RB; Fyhrquist, F; Ibsen, H; Julius, S; Kjeldsen, SE; Kristianson, K; Lederballe-Pedersen, O; Lindholm, LH; Nieminen, MS; Omvik, P; Oparil, S; Reims, HM; Wedel, H, 2004) |
| "Our study provides novel evidence that chronic ethanol intake increases blood pressure, induces vascular oxidative stress and decreases nitric oxide (NO) bioavailability through AT1-dependent mechanisms." | 1.42 | Angiotensin type 1 receptor mediates chronic ethanol consumption-induced hypertension and vascular oxidative stress. ( Antunes-Rodrigues, J; Ceron, CS; Coelho, EB; Mecawi, AS; Passaglia, P; Tirapelli, CR, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Passaglia, P | 1 |
| Ceron, CS | 1 |
| Mecawi, AS | 1 |
| Antunes-Rodrigues, J | 1 |
| Coelho, EB | 1 |
| Tirapelli, CR | 1 |
| Ariansen, I | 1 |
| Reims, HM | 2 |
| Gjesdal, K | 1 |
| Olsen, MH | 1 |
| Ibsen, H | 2 |
| Devereux, RB | 2 |
| Okin, PM | 1 |
| Kjeldsen, SE | 2 |
| Dahlöf, B | 2 |
| Wachtell, K | 1 |
| Dorado, P | 1 |
| Beltrán, LJ | 1 |
| Machín, E | 1 |
| Peñas-Lledó, EM | 1 |
| Terán, E | 1 |
| Llerena, A | 1 |
| Diener, HC | 1 |
| Brady, WE | 1 |
| Julius, S | 1 |
| Beevers, G | 1 |
| De Faire, U | 1 |
| Fyhrquist, F | 1 |
| Kristianson, K | 1 |
| Lederballe-Pedersen, O | 1 |
| Lindholm, LH | 1 |
| Nieminen, MS | 1 |
| Omvik, P | 1 |
| Oparil, S | 1 |
| Wedel, H | 1 |
| Grupp, LA | 2 |
| Harding, S | 2 |
| Szczepanska, R | 1 |
| Kraly, FS | 1 |
| Jones, KM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Triple-Blind, Parallel Study to Investigate the Effect of Losartan Versus Atenolol on the Reduction of Morbidity and Mortality in Hypertensive Patients With Left Ventricular Hypertrophy[NCT00338260] | Phase 3 | 496 participants (Actual) | Interventional | 1995-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for losartan and Alcohol Drinking
| Article | Year |
|---|---|
Impact of alcohol habits and smoking on the risk of new-onset atrial fibrillation in hypertensive patients with ECG left ventricular hypertrophy: the LIFE study.
Topics: Aged; Alcohol Drinking; Analysis of Variance; Antihypertensive Agents; Atenolol; Atrial Fibrillation | 2012 |
Alcohol consumption and cardiovascular risk in hypertensives with left ventricular hypertrophy: the LIFE study.
Topics: Aged; Aged, 80 and over; Alcohol Drinking; Antihypertensive Agents; Atenolol; Female; Humans; Hypert | 2004 |
7 other studies available for losartan and Alcohol Drinking
| Article | Year |
|---|---|
Angiotensin type 1 receptor mediates chronic ethanol consumption-induced hypertension and vascular oxidative stress.
Topics: Alcohol Drinking; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Arteries; | 2015 |
Losartan hydroxylation phenotype in an Ecuadorian population: influence of CYP2C9 genetic polymorphism, habits and gender.
Topics: Adult; Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Caffeine; Coffee; Cytochrome P-450 CYP2C9; F | 2012 |
[Primary prevention of stroke. What helps--what does not help? The guidelines of the German Society of Neurology briefly summarized].
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aged; Alcohol Drinking; Anticholesteremic | 2003 |
Adult hypertension: reducing cardiovascular morbidity and mortality.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Alcohol Drinking | 2005 |
The reduction in alcohol drinking by peripherally injected angiotensin II is selectively mediated by the AT1 receptor subtype.
Topics: Alcohol Drinking; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Dos | 1994 |
Characterization of the decline in alcohol consumption by aminopeptidase inhibition.
Topics: Alcohol Drinking; Aminopeptidases; Angiotensin II; Animals; Biphenyl Compounds; Dose-Response Relati | 1996 |
Histaminergic activation of endogenous angiotensin II fails to inhibit alcohol intake in rats.
Topics: Alcohol Drinking; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Ethanol; Histamine; Inj | 1999 |