losartan has been researched along with Acute Lung Injury in 11 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Acute Lung Injury: A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the effect of losartan, angiotensin II receptor type 1 (AT1) receptor antagonist, on the pulmonary T helper (Th) cell polarization response in acute lung injury (ALI) mice." | 7.80 | [Losartan modulates T helper type 1 cells and T helper type 17 cells-mediated responses in a mouse model of lipopolysaccharide-induced acute lung injury]. ( Guo, F; He, H; Huang, Y; Liu, J; Liu, L; Qiu, H; Yang, Y; Yu, T; Zhang, P, 2014) |
| "To assess the effects of losartan on the frequency and phenotype of respiratory dendritic cells (DC) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) mice." | 7.80 | [Effects of losartan on pulmonary dendritic cells in lipopolysaccharide- induced acute lung injury mice]. ( Liu, J; Qiu, H; Yang, Y; Yu, T; Zhang, P, 2014) |
| "To study the effect of angiotensin II (Ang II) and losartan, which is an angiotensin II type 1 receptor (AT1R) antagonist, on expression of AT2R in rat lung and the relationship between AT2R with acute lung injury (ALI)." | 7.74 | [Angiotensin II type 2 receptor expression and its modulation in angiotensin II induced acute lung injury in rat]. ( Chen, QH; Guo, T; Liu, L; Qiu, HB; Yang, Y; Zhao, MM; Zhu, Y, 2008) |
| "Losartan treatment significantly attenuated TNF-alpha, IL-6, and IL-1beta 6 h after CLP." | 5.35 | Losartan prevents sepsis-induced acute lung injury and decreases activation of nuclear factor kappaB and mitogen-activated protein kinases. ( Cai, L; Kong, T; Mo, H; Qi, J; Shen, L; Xiao, Z; Ye, J; Zheng, W, 2009) |
| "To assess the effect of losartan, angiotensin II receptor type 1 (AT1) receptor antagonist, on the pulmonary T helper (Th) cell polarization response in acute lung injury (ALI) mice." | 3.80 | [Losartan modulates T helper type 1 cells and T helper type 17 cells-mediated responses in a mouse model of lipopolysaccharide-induced acute lung injury]. ( Guo, F; He, H; Huang, Y; Liu, J; Liu, L; Qiu, H; Yang, Y; Yu, T; Zhang, P, 2014) |
| "To assess the effects of losartan on the frequency and phenotype of respiratory dendritic cells (DC) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) mice." | 3.80 | [Effects of losartan on pulmonary dendritic cells in lipopolysaccharide- induced acute lung injury mice]. ( Liu, J; Qiu, H; Yang, Y; Yu, T; Zhang, P, 2014) |
| "To study the effect of angiotensin II (Ang II) and losartan, which is an angiotensin II type 1 receptor (AT1R) antagonist, on expression of AT2R in rat lung and the relationship between AT2R with acute lung injury (ALI)." | 3.74 | [Angiotensin II type 2 receptor expression and its modulation in angiotensin II induced acute lung injury in rat]. ( Chen, QH; Guo, T; Liu, L; Qiu, HB; Yang, Y; Zhao, MM; Zhu, Y, 2008) |
| "Losartan is a selective antagonist of AngⅠ type (AT1) receptor of Angiotensin Ⅱ (Ang Ⅱ), which is widely used as a clinical medicine for the hypertension." | 1.46 | Losartan, a selective antagonist of AT1 receptor, attenuates seawater inhalation induced lung injury via modulating JAK2/STATs and apoptosis in rat. ( Bo, L; Jin, F; Li, C; Li, P; Li, W; Liu, W; Lu, X; Mu, D; Pan, L; Sun, Y, 2017) |
| "Acute lung injury was induced in wild-type mice and angiotensin-coverting enzyme 2 (ACE2) knockout mice by the intratracheal instillation of cationic polyamidoamine dendrimer (PAMAM) nanoparticles." | 1.42 | Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice. ( Gao, J; Guo, F; Han, Z; Hong, X; Jiang, C; Kuba, K; Li, B; Li, C; Li, D; Li, Q; Liu, H; Liu, K; Mo, Z; Penninger, JM; Song, B; Sun, Y; Wang, C; Wang, H; Yang, P; Zhao, Y; Zhong, N; Zou, Z, 2015) |
| "Losartan (10 mg/kg) was administered by gavage daily, starting from 1 d before LPS stimulation." | 1.39 | Angiotensin-(1-7) attenuates lung fibrosis by way of Mas receptor in acute lung injury. ( Chen, Q; Huang, Y; Liu, L; Pan, C; Qiu, H; Yang, Y, 2013) |
| "Losartan treatment significantly attenuated TNF-alpha, IL-6, and IL-1beta 6 h after CLP." | 1.35 | Losartan prevents sepsis-induced acute lung injury and decreases activation of nuclear factor kappaB and mitogen-activated protein kinases. ( Cai, L; Kong, T; Mo, H; Qi, J; Shen, L; Xiao, Z; Ye, J; Zheng, W, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 8 (72.73) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, C | 3 |
| Bo, L | 1 |
| Li, P | 1 |
| Lu, X | 1 |
| Li, W | 1 |
| Pan, L | 1 |
| Sun, Y | 2 |
| Mu, D | 1 |
| Liu, W | 1 |
| Jin, F | 1 |
| Chen, Q | 1 |
| Yang, Y | 6 |
| Huang, Y | 2 |
| Pan, C | 1 |
| Liu, L | 5 |
| Qiu, H | 3 |
| Yang, P | 2 |
| Gu, H | 1 |
| Zhao, Z | 1 |
| Wang, W | 1 |
| Cao, B | 1 |
| Lai, C | 1 |
| Yang, X | 1 |
| Zhang, L | 1 |
| Duan, Y | 1 |
| Zhang, S | 1 |
| Chen, W | 1 |
| Zhen, W | 1 |
| Cai, M | 1 |
| Penninger, JM | 2 |
| Jiang, C | 3 |
| Wang, X | 1 |
| Liu, J | 3 |
| Zhang, P | 2 |
| He, H | 1 |
| Yu, T | 2 |
| Guo, F | 2 |
| Yan, Y | 1 |
| Liu, Q | 1 |
| Li, N | 1 |
| Du, J | 1 |
| Li, X | 1 |
| Jin, N | 1 |
| Zou, Z | 1 |
| Hong, X | 1 |
| Zhao, Y | 1 |
| Wang, C | 2 |
| Wang, H | 1 |
| Liu, H | 1 |
| Han, Z | 1 |
| Liu, K | 1 |
| Kuba, K | 1 |
| Song, B | 1 |
| Gao, J | 1 |
| Mo, Z | 1 |
| Li, D | 1 |
| Li, B | 1 |
| Li, Q | 1 |
| Zhong, N | 1 |
| Shen, L | 1 |
| Mo, H | 1 |
| Cai, L | 1 |
| Kong, T | 1 |
| Zheng, W | 1 |
| Ye, J | 1 |
| Qi, J | 1 |
| Xiao, Z | 1 |
| Zhu, Y | 1 |
| Qiu, HB | 3 |
| Zhao, MM | 1 |
| Chen, QH | 1 |
| Guo, T | 1 |
| Wang, L | 1 |
| Ding, HM | 1 |
| Li, HP | 1 |
| Zhang, PS | 1 |
| Yu, Q | 1 |
| Guo, FM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Apelin; ACE2 and Biomarkers of Alveolar-capillary Permeability in SARS-cov-2 (COVID-19).[NCT04632732] | 140 participants (Actual) | Observational [Patient Registry] | 2020-10-26 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 other studies available for losartan and Acute Lung Injury
| Article | Year |
|---|---|
Losartan, a selective antagonist of AT1 receptor, attenuates seawater inhalation induced lung injury via modulating JAK2/STATs and apoptosis in rat.
Topics: Acute Lung Injury; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Apopt | 2017 |
Angiotensin-(1-7) attenuates lung fibrosis by way of Mas receptor in acute lung injury.
Topics: Acute Lung Injury; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; | 2013 |
Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury.
Topics: Acute Lung Injury; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; | 2014 |
[Losartan modulates T helper type 1 cells and T helper type 17 cells-mediated responses in a mouse model of lipopolysaccharide-induced acute lung injury].
Topics: Acute Lung Injury; Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, Animal; Enzyme- | 2014 |
[Effects of losartan on pulmonary dendritic cells in lipopolysaccharide- induced acute lung injury mice].
Topics: Acute Lung Injury; Animals; Dendritic Cells; Enzyme-Linked Immunosorbent Assay; Interleukin-6; Lipop | 2014 |
Angiotensin II receptor blocker as a novel therapy in acute lung injury induced by avian influenza A H5N1 virus infection in mouse.
Topics: Acute Lung Injury; Angiotensin II Type 1 Receptor Blockers; Animals; Birds; Host-Pathogen Interactio | 2015 |
Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice.
Topics: Acute Lung Injury; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animal | 2015 |
Losartan prevents sepsis-induced acute lung injury and decreases activation of nuclear factor kappaB and mitogen-activated protein kinases.
Topics: Acute Lung Injury; Angiotensin II Type 1 Receptor Blockers; Animals; Blotting, Western; Interleukin- | 2009 |
[Angiotensin II type 2 receptor expression and its modulation in angiotensin II induced acute lung injury in rat].
Topics: Acute Lung Injury; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, | 2008 |
Losartan, an antagonist of AT1 receptor for angiotensin II, attenuates lipopolysaccharide-induced acute lung injury in rat.
Topics: Acute Lung Injury; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Lipo | 2009 |
Losartan inhibits conventional dendritic cell maturation and Th1 and Th17 polarization responses: Νovel mechanisms of preventive effects on lipopolysaccharide-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Cytokines; Dendritic Cells; Lipopolysaccharides; Losartan; Male; Mice; M | 2012 |