losartan has been researched along with Acidosis in 4 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Losartan and enalapril may be beneficial in pediatric kidney transplant recipients by decreasing blood pressure and proteinuria, with maintenance of stable graft function, but may be associated with serious adverse events including hyperkalemia and life-threatening acidosis." | 7.80 | Acidosis and hyperkalemia caused by losartan and enalapril in pediatric kidney transplant recipients. ( Baskın, E; Bayrakcı, US; Haberal, M; Moray, G; Sakallı, H, 2014) |
| " We examined the modulatory effect of the type 1 angiotensin II receptor blocker losartan on the ability of metabolic acidosis to stimulate ammonia production and secretion by mouse S2 proximal tubule segments." | 7.74 | Role of angiotensin II in the enhancement of ammonia production and secretion by the proximal tubule in metabolic acidosis. ( Nagami, GT, 2008) |
| "Losartan and enalapril may be beneficial in pediatric kidney transplant recipients by decreasing blood pressure and proteinuria, with maintenance of stable graft function, but may be associated with serious adverse events including hyperkalemia and life-threatening acidosis." | 3.80 | Acidosis and hyperkalemia caused by losartan and enalapril in pediatric kidney transplant recipients. ( Baskın, E; Bayrakcı, US; Haberal, M; Moray, G; Sakallı, H, 2014) |
| " We examined the modulatory effect of the type 1 angiotensin II receptor blocker losartan on the ability of metabolic acidosis to stimulate ammonia production and secretion by mouse S2 proximal tubule segments." | 3.74 | Role of angiotensin II in the enhancement of ammonia production and secretion by the proximal tubule in metabolic acidosis. ( Nagami, GT, 2008) |
| " The purpose of the present study was to elucidate the capability of losartan, a nonpeptide angiotensin II type 1 (AT1) receptor antagonist, to attenuate splanchnic blood flow disturbances and counteract intestinal mucosal acidosis in endotoxin shock." | 3.70 | Angiotensin II receptor antagonism increases gut oxygen delivery but fails to improve intestinal mucosal acidosis in porcine endotoxin shock. ( Alving, K; Oldner, A; Rudehill, A; Rundgren, M; Ullman, J; Wanecek, M; Weitzberg, E, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sakallı, H | 1 |
| Baskın, E | 1 |
| Bayrakcı, US | 1 |
| Moray, G | 1 |
| Haberal, M | 1 |
| Nagami, GT | 1 |
| Oldner, A | 1 |
| Wanecek, M | 1 |
| Weitzberg, E | 1 |
| Rundgren, M | 1 |
| Alving, K | 1 |
| Ullman, J | 1 |
| Rudehill, A | 1 |
| Henger, A | 1 |
| Tutt, P | 1 |
| Riesen, WF | 1 |
| Hulter, HN | 1 |
| Krapf, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Correction of Metabolic Acidosis in CKD on Intrarenal RAS Activity[NCT02896309] | 45 participants (Actual) | Interventional | 2016-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for losartan and Acidosis
| Article | Year |
|---|---|
Acidosis and hyperkalemia caused by losartan and enalapril in pediatric kidney transplant recipients.
Topics: Acidosis; Adolescent; Age Factors; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting E | 2014 |
Role of angiotensin II in the enhancement of ammonia production and secretion by the proximal tubule in metabolic acidosis.
Topics: Acidosis; Ammonia; Ammonium Chloride; Angiotensin II; Animals; Disease Models, Animal; Kidney Cortex | 2008 |
Angiotensin II receptor antagonism increases gut oxygen delivery but fails to improve intestinal mucosal acidosis in porcine endotoxin shock.
Topics: Acidosis; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Dose-Response Relation | 1999 |
Acid-base and endocrine effects of aldosterone and angiotensin II inhibition in metabolic acidosis in human patients.
Topics: Acid-Base Equilibrium; Acidosis; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Chronic D | 2000 |