Page last updated: 2024-10-30

losartan and Acidosis

losartan has been researched along with Acidosis in 4 studies

Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position

Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.

Research Excerpts

ExcerptRelevanceReference
"Losartan and enalapril may be beneficial in pediatric kidney transplant recipients by decreasing blood pressure and proteinuria, with maintenance of stable graft function, but may be associated with serious adverse events including hyperkalemia and life-threatening acidosis."7.80Acidosis and hyperkalemia caused by losartan and enalapril in pediatric kidney transplant recipients. ( Baskın, E; Bayrakcı, US; Haberal, M; Moray, G; Sakallı, H, 2014)
" We examined the modulatory effect of the type 1 angiotensin II receptor blocker losartan on the ability of metabolic acidosis to stimulate ammonia production and secretion by mouse S2 proximal tubule segments."7.74Role of angiotensin II in the enhancement of ammonia production and secretion by the proximal tubule in metabolic acidosis. ( Nagami, GT, 2008)
"Losartan and enalapril may be beneficial in pediatric kidney transplant recipients by decreasing blood pressure and proteinuria, with maintenance of stable graft function, but may be associated with serious adverse events including hyperkalemia and life-threatening acidosis."3.80Acidosis and hyperkalemia caused by losartan and enalapril in pediatric kidney transplant recipients. ( Baskın, E; Bayrakcı, US; Haberal, M; Moray, G; Sakallı, H, 2014)
" We examined the modulatory effect of the type 1 angiotensin II receptor blocker losartan on the ability of metabolic acidosis to stimulate ammonia production and secretion by mouse S2 proximal tubule segments."3.74Role of angiotensin II in the enhancement of ammonia production and secretion by the proximal tubule in metabolic acidosis. ( Nagami, GT, 2008)
" The purpose of the present study was to elucidate the capability of losartan, a nonpeptide angiotensin II type 1 (AT1) receptor antagonist, to attenuate splanchnic blood flow disturbances and counteract intestinal mucosal acidosis in endotoxin shock."3.70Angiotensin II receptor antagonism increases gut oxygen delivery but fails to improve intestinal mucosal acidosis in porcine endotoxin shock. ( Alving, K; Oldner, A; Rudehill, A; Rundgren, M; Ullman, J; Wanecek, M; Weitzberg, E, 1999)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's2 (50.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sakallı, H1
Baskın, E1
Bayrakcı, US1
Moray, G1
Haberal, M1
Nagami, GT1
Oldner, A1
Wanecek, M1
Weitzberg, E1
Rundgren, M1
Alving, K1
Ullman, J1
Rudehill, A1
Henger, A1
Tutt, P1
Riesen, WF1
Hulter, HN1
Krapf, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Correction of Metabolic Acidosis in CKD on Intrarenal RAS Activity[NCT02896309]45 participants (Actual)Interventional2016-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

4 other studies available for losartan and Acidosis

ArticleYear
Acidosis and hyperkalemia caused by losartan and enalapril in pediatric kidney transplant recipients.
    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2014, Volume: 12, Issue:4

    Topics: Acidosis; Adolescent; Age Factors; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting E

2014
Role of angiotensin II in the enhancement of ammonia production and secretion by the proximal tubule in metabolic acidosis.
    American journal of physiology. Renal physiology, 2008, Volume: 294, Issue:4

    Topics: Acidosis; Ammonia; Ammonium Chloride; Angiotensin II; Animals; Disease Models, Animal; Kidney Cortex

2008
Angiotensin II receptor antagonism increases gut oxygen delivery but fails to improve intestinal mucosal acidosis in porcine endotoxin shock.
    Shock (Augusta, Ga.), 1999, Volume: 11, Issue:2

    Topics: Acidosis; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Dose-Response Relation

1999
Acid-base and endocrine effects of aldosterone and angiotensin II inhibition in metabolic acidosis in human patients.
    The Journal of laboratory and clinical medicine, 2000, Volume: 136, Issue:5

    Topics: Acid-Base Equilibrium; Acidosis; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Chronic D

2000