lorglumide has been researched along with Pancreatic Neoplasms in 10 studies
lorglumide: RN given refers to (+-)-isomer
lorglumide : A racemate comprising equal amounts of (R)- and (S)-lorglumide.
N(2)-(3,4-dichlorobenzoyl)-N,N-dipentyl-alpha-glutamine : A dicarboxylic acid monoamide obtained by formal condensation of the alpha-carboxy group of N-(3,4-dichlorobenzoyl)glutamic acid with the amino group of dipentylamine.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The incidence of pancreatic cancer appeared significantly (P < 0." | 1.29 | Effect of cholecystokinin analogue caerulein and cholecystokinin antagonist lorglumide on pancreatic carcinogenesis in the rat. ( Alaggio, R; Behboo, R; Khajeturian, E; Militello, C; Pedrazzoli, S; Perasole, A; Rovati, L; Sperti, C, 1994) |
| "Cholecystokinin and bombesin have been shown to promote pancreatic growth and development of azaserine-induced acidophilic atypical acinar cell nodules in rat pancreas after treatment for 16 weeks." | 1.28 | Effects of cholecystokinin and bombesin on development of azaserine-induced pancreatic tumours in rats: modulation by the cholecystokinin receptor antagonist lorglumide. ( Appel, MJ; Jansen, JB; Lamers, CB; Meijers, M; Rovati, LC; van Garderen-Hoetmer, A; Woutersen, RA, 1992) |
| "Rats treated with cholecystokinin developed more acidophilic atypical acinar cell nodules, adenomas and adenocarcinomas than control animals." | 1.28 | Role of cholecystokinin in dietary fat-promoted azaserine-induced pancreatic carcinogenesis in rats. ( Appel, MJ; Jansen, JB; Lamers, CB; Meijers, M; Rovati, LC; Sprij-Mooij, D; Van Garderen-Hoetmer, A; Woutersen, RA, 1992) |
| "Camostate caused an increase in growth of the pancreas and a decrease in the number of (pre)neoplastic ductular pancreatic lesions." | 1.28 | Effects of the synthetic trypsin inhibitor camostate on the development of N-nitrosobis(2-oxopropyl)amine-induced pancreatic lesions in hamsters. ( Jansen, JB; Lamers, CB; Meijers, M; Rovati, LC; van Garderen-Hoetmer, A; Woutersen, RA, 1991) |
| "Cholecystokinin (CCK) has been shown to promote pancreatic growth and azaserine-induced pancreatic carcinogenesis in rats." | 1.28 | Role of cholecystokinin in the development of BOP-induced pancreatic lesions in hamsters. ( Jansen, JB; Lamers, CB; Meijers, M; Rovati, LC; van Garderen-Hoetmer, A; Woutersen, RA, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 9 (90.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sperti, C | 1 |
| Militello, C | 1 |
| Rovati, L | 1 |
| Behboo, R | 1 |
| Khajeturian, E | 1 |
| Perasole, A | 1 |
| Alaggio, R | 1 |
| Pedrazzoli, S | 1 |
| Karsenty, L | 1 |
| Hajri, A | 1 |
| Aprahamian, M | 1 |
| Garaud, JC | 1 |
| Doffoël, M | 1 |
| Damgé, C | 1 |
| Watanapa, P | 1 |
| Flaks, B | 1 |
| Oztas, H | 1 |
| Deprez, PH | 1 |
| Calam, J | 1 |
| Williamson, RC | 1 |
| Meijers, M | 5 |
| Appel, MJ | 2 |
| van Garderen-Hoetmer, A | 5 |
| Lamers, CB | 6 |
| Rovati, LC | 6 |
| Jansen, JB | 6 |
| Woutersen, RA | 6 |
| Sprij-Mooij, D | 1 |
| Seva, C | 1 |
| Scemama, JL | 1 |
| Bastié, MJ | 1 |
| Pradayrol, L | 1 |
| Vaysse, N | 1 |
| Douglas, BR | 1 |
| de Jong, AJ | 1 |
10 other studies available for lorglumide and Pancreatic Neoplasms
| Article | Year |
|---|---|
Effect of cholecystokinin analogue caerulein and cholecystokinin antagonist lorglumide on pancreatic carcinogenesis in the rat.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Body Weight; Ceruletide; Chi-Square Distr | 1994 |
Inhibition of growth of a transplanted rat pancreatic acinar carcinoma with CCK-8.
Topics: Animals; Carcinoma; Cell Division; Dose-Response Relationship, Drug; Neoplasm Transplantation; Pancr | 1993 |
Inhibitory effect of a cholecystokinin antagonist on pancreatic carcinogenesis after pancreatobiliary diversion.
Topics: Animals; Azaserine; Biliopancreatic Diversion; Body Weight; Cholecystokinin; Cocarcinogenesis; Male; | 1993 |
Effects of cholecystokinin and bombesin on development of azaserine-induced pancreatic tumours in rats: modulation by the cholecystokinin receptor antagonist lorglumide.
Topics: Animals; Azaserine; Bombesin; Carcinogens; Cholecystokinin; Drug Synergism; Male; Pancreatic Neoplas | 1992 |
Role of cholecystokinin in dietary fat-promoted azaserine-induced pancreatic carcinogenesis in rats.
Topics: Animals; Azaserine; Body Weight; Cholecystokinin; Dietary Fats; Liver; Male; Organ Size; Pancreas; P | 1992 |
Effects of the synthetic trypsin inhibitor camostate on the development of N-nitrosobis(2-oxopropyl)amine-induced pancreatic lesions in hamsters.
Topics: Animals; Carcinogens; Carcinoma; Carcinoma in Situ; Cholecystokinin; Cricetinae; Esters; Gabexate; G | 1991 |
Effects of bombesin on the development of N-nitrosobis(2-oxopropyl)amine-induced pancreatic lesions in hamsters.
Topics: Animals; Body Weight; Bombesin; Cholecystokinin; Cricetinae; Liver; Male; Mesocricetus; Nitrosamines | 1991 |
Role of cholecystokinin in the development of BOP-induced pancreatic lesions in hamsters.
Topics: Animals; Body Weight; Carcinogens; Cholecystokinin; Cocarcinogenesis; Cricetinae; Male; Nitrosamines | 1990 |
Lorglumide and loxiglumide inhibit gastrin-stimulated DNA synthesis in a rat tumoral acinar pancreatic cell line (AR42J).
Topics: Animals; DNA, Neoplasm; Gastrins; Glutamine; Ornithine Decarboxylase; Pancreatic Neoplasms; Proglumi | 1990 |
Modulation by CR-1409 (lorglumide), a cholecystokinin receptor antagonist, of trypsin inhibitor-enhanced growth of azaserine-induced putative preneoplastic lesions in rat pancreas.
Topics: Animals; Azaserine; Cholecystokinin; Esters; Gabexate; Glutamine; Guanidines; Male; Pancreatic Neopl | 1989 |