lorglumide has been researched along with Muscle Contraction in 15 studies
lorglumide: RN given refers to (+-)-isomer
lorglumide : A racemate comprising equal amounts of (R)- and (S)-lorglumide.
N(2)-(3,4-dichlorobenzoyl)-N,N-dipentyl-alpha-glutamine : A dicarboxylic acid monoamide obtained by formal condensation of the alpha-carboxy group of N-(3,4-dichlorobenzoyl)glutamic acid with the amino group of dipentylamine.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Both antagonists caused a rightward shift of the dose-response curve for CCK-8s on the monkey iris sphincter." | 1.28 | Cholecystokinin contracts isolated human and monkey iris sphincters; a study with CCK receptor antagonists. ( Almegård, B; Bill, A; Stjernschantz, J, 1992) |
| "5 uM) caused a rightward shift of the dose-response curves of CCK-OP, with an increase of the ED50 from 8." | 1.28 | The effect of a novel CCK-antagonist (lorglumide) on human and guinea pig gallbladder strips: a tensiometric study. ( Brandonisio, R; Chiloiro, M; Di Ciaula, A; Maggi, V; Palasciano, G; Portincasa, P, 1990) |
| " The model was used to demonstrate a dose-response curve to bolus administration of exogenous cholecystokinin (0." | 1.28 | In vivo comparison of inhibition with proglumide and CR-1409 of cholecystokinin-induced pressure in the biliary tract of the guinea pig. ( Hashimoto, T; MacLellan, DG; Poston, GJ; Thompson, JC; Townsend, CM; Upp, JR, 1990) |
| "Pretreatment with lorglumide caused a dose-dependent rightward shift of the dose-response curve, indicating competitive antagonism." | 1.28 | Cholecystokinin causes contraction of the pupillary sphincter in monkeys but not in cats, rabbits, rats and guinea-pigs: antagonism by lorglumide. ( Almegård, B; Andersson, SE; Bill, A, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (20.00) | 18.7374 |
| 1990's | 6 (40.00) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Onaga, T | 1 |
| Sugita, A | 1 |
| Wakaiki, R | 1 |
| Hara, I | 1 |
| Kagawa, K | 1 |
| Kirisawa, R | 1 |
| Hayashi, H | 1 |
| Lv, Y | 1 |
| Feng, M | 1 |
| Che, T | 1 |
| Sun, H | 1 |
| Luo, Y | 1 |
| Liu, K | 1 |
| Liu, C | 1 |
| Latorre, M | 1 |
| Bartolomé-Nebreda, JM | 1 |
| García-López, MT | 1 |
| González-Muñiz, R | 1 |
| Herranz, R | 1 |
| Del Río, J | 1 |
| Cenarruzabeitia, E | 1 |
| Liu, JF | 1 |
| Gao, LP | 1 |
| Wen, SW | 1 |
| Lu, HL | 1 |
| Zhang, J | 1 |
| Sun, J | 1 |
| Zhang, SW | 1 |
| Wang, QZ | 1 |
| Wang, SX | 1 |
| Sterczer, A | 1 |
| Szénási, G | 1 |
| Vörös, K | 1 |
| Pap, A | 1 |
| Maselli, MA | 1 |
| Piepoli, AL | 1 |
| Pezzolla, F | 1 |
| Guerra, V | 1 |
| Caruso, ML | 1 |
| Mennuni, L | 1 |
| Lorusso, D | 1 |
| Makovec, F | 2 |
| Almegård, B | 2 |
| Stjernschantz, J | 1 |
| Bill, A | 2 |
| D'Amato, M | 1 |
| Stamford, IF | 1 |
| Bennett, A | 1 |
| Portincasa, P | 1 |
| Brandonisio, R | 1 |
| Di Ciaula, A | 1 |
| Maggi, V | 1 |
| Chiloiro, M | 1 |
| Palasciano, G | 1 |
| Poston, GJ | 1 |
| MacLellan, DG | 1 |
| Hashimoto, T | 1 |
| Upp, JR | 1 |
| Townsend, CM | 1 |
| Thompson, JC | 1 |
| Andersson, SE | 1 |
| Menozzi, D | 1 |
| Gardner, JD | 1 |
| Jensen, RT | 1 |
| Maton, PN | 1 |
| Bani, M | 1 |
| Cereda, R | 1 |
| Chisté, R | 1 |
| Pacini, MA | 1 |
| Revel, L | 1 |
| Rovati, LA | 1 |
| Rovati, LC | 1 |
| Setnikar, I | 2 |
| Barthó, L | 1 |
| Holzer, P | 1 |
| Lembeck, F | 1 |
| Lippe, IT | 1 |
15 other studies available for lorglumide and Muscle Contraction
| Article | Year |
|---|---|
Localization of CCK-1R in the omasum and role of CCK in the regulation of omasal contractions in sheep.
Topics: Animals; Atropine; Electromyography; Hormone Antagonists; In Vitro Techniques; Indoles; Meglumine; M | 2008 |
CCK mediated the inhibitory effect of oxytocin on the contraction of longitudinal muscle strips of duodenum in male rats.
Topics: Animals; Cholecystokinin; Duodenum; Gastrointestinal Motility; Male; Muscle Contraction; Myenteric P | 2010 |
Pharmacological study of IQM-97,423, a potent and selective CCK1 receptor antagonist with protective effect in experimental acute pancreatitis.
Topics: Acute Disease; alpha-Amylases; Animals; Binding, Competitive; Cerebral Cortex; Cholecystokinin; Deva | 2004 |
Responses of human sling and clasp fibers to cholecystokinin (CCK) and gastrin through CCK receptors.
Topics: Adult; Benzodiazepines; Dose-Response Relationship, Drug; Esophageal Sphincter, Lower; Esophagectomy | 2008 |
[Effect of cholecystokinin and its antagonists lorglumide, devazepide, and L-365,260 on gastrointestinal motility in rats].
Topics: Animals; Benzodiazepinones; Devazepide; Gastric Emptying; Gastrointestinal Motility; Guinea Pigs; Il | 1993 |
Effects of lorglumide and atropine on MgSO(4)-induced gallbladder emptying in conscious dogs.
Topics: Animals; Atropine; Cholecystokinin; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Femal | 2000 |
Effect of three nonpeptide cholecystokinin antagonists on human isolated gallbladder.
Topics: Cholecystokinin; Gallbladder; Hormone Antagonists; Humans; In Vitro Techniques; Muscle Contraction; | 2001 |
Cholecystokinin contracts isolated human and monkey iris sphincters; a study with CCK receptor antagonists.
Topics: Aged; Aged, 80 and over; Animals; Cholecystokinin; Female; Humans; In Vitro Techniques; Iris; Macaca | 1992 |
Studies of three non-peptide cholecystokinin antagonists (devazepide, lorglumide and loxiglumide) in human isolated alimentary muscle and guinea-pig ileum.
Topics: Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Digestive System; Digestive System Physiolo | 1991 |
The effect of a novel CCK-antagonist (lorglumide) on human and guinea pig gallbladder strips: a tensiometric study.
Topics: Adult; Aged; Animals; Dose-Response Relationship, Drug; Gallbladder; Guinea Pigs; Humans; Male; Midd | 1990 |
In vivo comparison of inhibition with proglumide and CR-1409 of cholecystokinin-induced pressure in the biliary tract of the guinea pig.
Topics: Animals; Cholecystokinin; Dose-Response Relationship, Drug; Gallbladder; Glutamine; Guinea Pigs; Mal | 1990 |
Cholecystokinin causes contraction of the pupillary sphincter in monkeys but not in cats, rabbits, rats and guinea-pigs: antagonism by lorglumide.
Topics: Animals; Cats; Cholecystokinin; Eye; Female; Guinea Pigs; Indomethacin; Macaca; Macaca fascicularis; | 1990 |
Properties of receptors for gastrin and CCK on gastric smooth muscle cells.
Topics: Amylases; Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Gastrins; Guinea Pigs; Male; Musc | 1989 |
Pharmacological properties of lorglumide as a member of a new class of cholecystokinin antagonists.
Topics: Animals; Cholecystokinin; Dogs; Gallbladder; Glutamine; Guinea Pigs; Ileum; In Vitro Techniques; Mic | 1987 |
Evaluation of a new and potent cholecystokinin antagonist on motor responses of the guinea-pig intestine.
Topics: Animals; Cholecystokinin; Dose-Response Relationship, Drug; Electric Stimulation; Female; Glutamine; | 1987 |