lorazepam has been researched along with Sleep Initiation and Maintenance Disorders in 60 studies
Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
Sleep Initiation and Maintenance Disorders: Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A total of 18 brain-injured and stroke patients, aged 20-78 yrs, were administered lorazepam, 0." | 9.11 | Comparison of lorazepam and zopiclone for insomnia in patients with stroke and brain injury: a randomized, crossover, double-blinded trial. ( Ashworth, NL; Li Pi Shan, RS, 2004) |
| "Hypnotic efficacy and safety of 3 weeks of daily doses of 2 mg lorazepam or 30 mg flurazepam were compared in a double-blind cross-over study in eight chronic insomniacs between the ages of 29 and 60 years." | 9.06 | Comparison of lorazepam and flurazepam as hypnotic agents in chronic insomniacs. ( Chang, H; McClure, DJ; Olah, A; Pecknold, JC; Walsh, J; Wilson, R, 1988) |
| "Patients with primary insomnia typically complain of daytime fatigue and stress and have been shown to have long latencies on the Multiple Sleep Latency Test and increased whole body metabolism." | 6.69 | The use of lorazepam TID for chronic insomnia. ( Arand, DL; Bonnet, MH, 1999) |
| "Lormetazepam was found to be an effective hypnotic that causes virtually no hangover the next morning." | 6.65 | Lormetazepam - a benzodiazepine derivative without hangover effect? A double-blind study with chronic insomniacs in a general practice setting. ( Beach, RC; Heidrich, H; Ott, H, 1981) |
| "Aripiprazole response was prospectively assessed for 16 weeks using the Montgomery-Asberg Depression Rating Scale (MADRS), the Clinical Global Impression Severity Scale (CGI-S), and the Young Mania Rating Scale in 85 bipolar patients with acute depression inadequately responsive to one mood stabilizer." | 5.13 | Beneficial acute antidepressant effects of aripiprazole as an adjunctive treatment or monotherapy in bipolar patients unresponsive to mood stabilizers: results from a 16-week open-label trial. ( Bria, P; Janiri, L; Mazza, M; Pecora, RD; Squillacioti, MR, 2008) |
| " A total of 18 brain-injured and stroke patients, aged 20-78 yrs, were administered lorazepam, 0." | 5.11 | Comparison of lorazepam and zopiclone for insomnia in patients with stroke and brain injury: a randomized, crossover, double-blinded trial. ( Ashworth, NL; Li Pi Shan, RS, 2004) |
| "Hypnotic efficacy and safety of 3 weeks of daily doses of 2 mg lorazepam or 30 mg flurazepam were compared in a double-blind cross-over study in eight chronic insomniacs between the ages of 29 and 60 years." | 5.06 | Comparison of lorazepam and flurazepam as hypnotic agents in chronic insomniacs. ( Chang, H; McClure, DJ; Olah, A; Pecknold, JC; Walsh, J; Wilson, R, 1988) |
| "The effects of 3 mg lorazepam on polysomnographic recordings, performance, anxiety, and perceived sleep were examined." | 5.05 | Effects of lorazepam and its withdrawal on sleep, performance, and subjective state. ( Parwatikar, S; Schweitzer, PK; Walsh, JK, 1983) |
| "They had suffered from insomnia for several years and showed a high impairment according to the Pittsburgh Sleep Quality Index." | 2.77 | Effectiveness of a cognitive behavioral self-help program for patients with primary insomnia in general practice - a pilot study. ( Backhaus, J; Hohagen, F; Hüppe, M; Junghanns, K; Katofsky, I; Rumpf, HJ; von Eitzen, U, 2012) |
| "No rebound insomnia was reported during follow-up in patients in the lormetazepam group." | 2.73 | Role of lormetazepam in the treatment of insomnia in the elderly. ( Aguglia, E; De Vanna, M; Onor, ML; Rubiera, M, 2007) |
| "Lormetazepam is a short-acting benzodiazepine hypnotic which is beneficial in shortening the time to onset of sleep." | 2.71 | A randomized clinical trial comparing doses and efficacy of lormetazepam tablets or oral solution for insomnia in a general practice setting. ( Alquier, C; Ancolio, C; Blin, O; Micallef, J; Pradel, V; Soubrouillard, C; Tardieu, S, 2004) |
| "The perceived degree of improvement of insomnia was proportional to the advance in timing of sleep onset obtained with treatment." | 2.71 | Lormetazepam in depressive insomnia: new evidence of phase-response effects of benzodiazepines. ( Benedetti, F; Bernasconi, A; Colombo, C; Florita, M; Pontiggia, A; Smeraldi, E, 2004) |
| "Trimipramine did not suppress REM sleep." | 2.70 | Trimipramine in primary insomnia: results of a polysomnographic double-blind controlled study. ( Baghai, T; Berger, M; Cohrs, S; Fischer, W; Hajak, G; Hoffmann, M; Hohagen, F; Laakmann, G; Mayer, G; Riemann, D; Rodenbeck, A; Rüther, E; Voderholzer, U; Wiegand, MH, 2002) |
| "Benzodiazepine use in the treatment of insomnia may cause benzodiazepine dependence, especially in opiate users." | 2.69 | Amitriptyline vs. lorazepam in the treatment of opiate-withdrawal insomnia: a randomized double-blind study. ( Jarusuraisin, N; Srisurapanont, M, 1998) |
| "Patients with primary insomnia typically complain of daytime fatigue and stress and have been shown to have long latencies on the Multiple Sleep Latency Test and increased whole body metabolism." | 2.69 | The use of lorazepam TID for chronic insomnia. ( Arand, DL; Bonnet, MH, 1999) |
| "Since homogeneous samples of insomniacs are difficult to recruit for pharmacotherapy studies, normal sleepers can be used to assess the protective effect of hypnotic drugs, under standardized nonconducive conditions." | 2.68 | Multidrug comparison (lorazepam, triazolam, zolpidem, and zopiclone) in situational insomnia: polysomnographic analysis by means of the cyclic alternating pattern. ( Boselli, M; Parrino, L; Smerieri, A; Spaggiari, MC; Terzano, MG, 1997) |
| "Physicians' global evaluation of insomnia demonstrated no changes in the pre-drug placebo period, moderate improvement under both drugs, with a marginal advantage of SOM over LOR in the first 2 weeks, and a return to pre-drug values in the post-drug placebo period." | 2.68 | Nonorganic insomnia in generalized anxiety disorder. 2. Comparative studies on sleep, awakening, daytime vigilance and anxiety under lorazepam plus diphenhydramine (Somnium) versus lorazepam alone, utilizing clinical, polysomnographic and EEG mapping meth ( Anderer, P; Brandstätter, N; Frey, R; Gruber, G; Grünberger, J; Klösch, G; Linzmayer, L; Mandl, M; Saletu, B; Saletu-Zyhlarz, G, 1997) |
| "Lormetazepam was found to be an effective hypnotic that causes virtually no hangover the next morning." | 2.65 | Lormetazepam - a benzodiazepine derivative without hangover effect? A double-blind study with chronic insomniacs in a general practice setting. ( Beach, RC; Heidrich, H; Ott, H, 1981) |
| "Lormetazepam (Noctamid) at a dosage of 1 mg was compared with diazepam (Valium) at a dosage of 5 mg in a 7-day double-blind study." | 2.65 | Comparative efficacy of lormetazepam (Noctamid) and diazepam (Valium) in 100 out-patients with insomnia. ( Fichte, K; Hentschel, HD; Sastre y Hernández, MS, 1981) |
| "Objective insomnia was measured polysomnographically and was present on at least two of the last three nights of four consecutive nights of placebo baseline." | 2.65 | Sleep laboratory study of lormetazepam in older insomniacs. ( Vogel, GW, 1984) |
| "Lormetazepam (1 and 2 mg) was tested against flurazepam (30 mg) and placebo in 60 patients (15 per treatment group) with initial, intermediate, or late insomnia." | 2.65 | Comparative study of lormetazepam and flurazepam in the treatment of insomnia. ( Melo de Paula, AJ, 1984) |
| " A 30-year-old female elite athlete developed lormetazepam addiction after increasing her daily benzodiazepine dosage in an attempt to achieve better sleep and enhanced performances during training." | 1.51 | Benzodiazepine abuse among athletes: Pain relief or just a weapon against insomnia? A clinical case study. ( Lugoboni, F; Zamboni, L; Zandonai, T, 2019) |
| "5 mg on the first night but were allowed to increase their dosage to 1." | 1.27 | Lormetazepam (Loramet) in the elderly: an acceptability study. ( Hossain, M; Joseph, DN, 1985) |
| "The benzodiazepine withdrawal symptoms are presented here." | 1.27 | Manic-like reaction induced by lorazepam withdrawal. ( Labelle, A; Lapierre, YD, 1987) |
| "Lorazepam, 4 mg, was evaluated in an 18-night sleep-laboratory study involving five insomniac subjects." | 1.26 | Lorazepam-efficacy, side effects, and rebound phenomena. ( Bixler, EO; Jacoby, JA; Kales, A; Scharf, MB; Schweitzer, PK, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (53.33) | 18.7374 |
| 1990's | 10 (16.67) | 18.2507 |
| 2000's | 13 (21.67) | 29.6817 |
| 2010's | 4 (6.67) | 24.3611 |
| 2020's | 1 (1.67) | 2.80 |
| Authors | Studies |
|---|---|
| Zamboni, L | 1 |
| Lugoboni, F | 2 |
| Zandonai, T | 1 |
| Dahl, T | 1 |
| Chen, LB | 1 |
| Zammit, G | 1 |
| Ahmad, M | 1 |
| Roth, T | 1 |
| Herrera-Huerta, CA | 1 |
| Hernández-Salas, LP | 1 |
| Magallanes-Cano, EM | 1 |
| Cosci, F | 1 |
| Mansueto, G | 1 |
| Faccini, M | 1 |
| Casari, R | 1 |
| Morgan, PT | 1 |
| Malison, RT | 1 |
| Mazza, M | 1 |
| Squillacioti, MR | 1 |
| Pecora, RD | 1 |
| Janiri, L | 1 |
| Bria, P | 1 |
| Porecha, S | 1 |
| shah, T | 1 |
| Jogani, V | 1 |
| Naik, S | 1 |
| Misra, A | 1 |
| Katofsky, I | 1 |
| Backhaus, J | 1 |
| Junghanns, K | 1 |
| Rumpf, HJ | 1 |
| Hüppe, M | 1 |
| von Eitzen, U | 1 |
| Hohagen, F | 2 |
| Riemann, D | 1 |
| Voderholzer, U | 1 |
| Cohrs, S | 1 |
| Rodenbeck, A | 1 |
| Hajak, G | 1 |
| Rüther, E | 1 |
| Wiegand, MH | 1 |
| Laakmann, G | 1 |
| Baghai, T | 1 |
| Fischer, W | 1 |
| Hoffmann, M | 1 |
| Mayer, G | 1 |
| Berger, M | 1 |
| Ancolio, C | 1 |
| Tardieu, S | 1 |
| Soubrouillard, C | 1 |
| Alquier, C | 1 |
| Pradel, V | 1 |
| Micallef, J | 1 |
| Blin, O | 1 |
| Li Pi Shan, RS | 1 |
| Ashworth, NL | 1 |
| Benedetti, F | 1 |
| Pontiggia, A | 1 |
| Bernasconi, A | 1 |
| Colombo, C | 1 |
| Florita, M | 1 |
| Smeraldi, E | 1 |
| Staner, L | 1 |
| Ertlé, S | 1 |
| Boeijinga, P | 1 |
| Rinaudo, G | 1 |
| Arnal, MA | 1 |
| Muzet, A | 1 |
| Luthringer, R | 1 |
| Watanabe, T | 1 |
| Ueda, M | 1 |
| Saeki, Y | 1 |
| Hirokane, G | 1 |
| Morita, S | 1 |
| Okawa, M | 1 |
| Akiyama, K | 1 |
| Shimoda, K | 1 |
| Zimbroff, DL | 1 |
| Marcus, RN | 1 |
| Manos, G | 1 |
| Stock, E | 1 |
| McQuade, RD | 1 |
| Auby, P | 1 |
| Oren, DA | 1 |
| De Vanna, M | 1 |
| Rubiera, M | 1 |
| Onor, ML | 1 |
| Aguglia, E | 1 |
| Rasmussen, KG | 1 |
| Mueller, M | 1 |
| Knapp, RG | 1 |
| Husain, MM | 1 |
| Rummans, TA | 1 |
| Sampson, SM | 1 |
| O'Connor, MK | 1 |
| Petrides, G | 1 |
| Fink, M | 1 |
| Kellner, CH | 1 |
| Linnoila, M | 1 |
| Viukari, M | 1 |
| Lamminsivu, U | 1 |
| Auvinen, J | 1 |
| Heidrich, H | 1 |
| Ott, H | 2 |
| Beach, RC | 1 |
| Sastre y Hernández, MS | 1 |
| Hentschel, HD | 1 |
| Fichte, K | 3 |
| Lapierre, YD | 2 |
| Scharf, MB | 1 |
| Kales, A | 3 |
| Bixler, EO | 3 |
| Jacoby, JA | 3 |
| Schweitzer, PK | 2 |
| Oswald, I | 1 |
| French, C | 1 |
| Adam, K | 1 |
| Gilham, J | 1 |
| Sastre-y-Hernández, M | 1 |
| Studer, A | 1 |
| Dement, W | 1 |
| Seidel, W | 1 |
| Carskadon, M | 1 |
| De Anna, M | 1 |
| Zucconi, M | 1 |
| Baruzzi, A | 1 |
| Cirignotta, F | 1 |
| Gallassi, R | 1 |
| Soverini, S | 1 |
| Ansseau, M | 1 |
| Diricq, S | 1 |
| Cohn, JB | 1 |
| Harris, PG | 1 |
| Di Perri, R | 1 |
| Vogel, GW | 1 |
| Guilleminault, C | 1 |
| Melo de Paula, AJ | 1 |
| Honorato Pérez, J | 1 |
| Cuena Boy, R | 1 |
| Rubio González, A | 1 |
| Azanza Perea, JR | 1 |
| Walsh, JK | 1 |
| Parwatikar, S | 1 |
| Ohayon, MM | 1 |
| Caulet, M | 1 |
| Jobert, M | 3 |
| Poiseau, E | 3 |
| Jähnig, P | 3 |
| Gaillard, P | 1 |
| Schulz, H | 3 |
| Cluydts, R | 1 |
| De Roeck, J | 1 |
| Cosyns, P | 1 |
| Lacante, P | 1 |
| Parrino, L | 1 |
| Boselli, M | 1 |
| Spaggiari, MC | 1 |
| Smerieri, A | 1 |
| Terzano, MG | 1 |
| Saletu, B | 2 |
| Saletu-Zyhlarz, G | 2 |
| Anderer, P | 1 |
| Brandstätter, N | 1 |
| Frey, R | 2 |
| Gruber, G | 1 |
| Klösch, G | 1 |
| Mandl, M | 1 |
| Grünberger, J | 2 |
| Linzmayer, L | 2 |
| Böck, G | 1 |
| Weissgram, S | 1 |
| Brandstaätter, N | 1 |
| Srisurapanont, M | 1 |
| Jarusuraisin, N | 1 |
| Bonnet, MH | 1 |
| Arand, DL | 1 |
| Wang, RI | 1 |
| Stockdale, SL | 1 |
| Hieb, E | 1 |
| Greenblatt, DJ | 1 |
| Shader, RI | 1 |
| Doenicke, A | 1 |
| Abress, C | 1 |
| Fischl, R | 1 |
| Hemmerling, KG | 1 |
| Kubicki, S | 2 |
| Kales, JD | 2 |
| Soldatos, CR | 2 |
| Joseph, DN | 1 |
| Hossain, M | 1 |
| Allen, RM | 1 |
| Chima, P | 1 |
| Beaumont, G | 1 |
| Lorizio, A | 1 |
| Salsa, F | 1 |
| McClure, DJ | 1 |
| Walsh, J | 1 |
| Chang, H | 1 |
| Olah, A | 1 |
| Wilson, R | 1 |
| Pecknold, JC | 1 |
| Richards, HH | 1 |
| Vallé-Jones, CJ | 1 |
| Overstall, PW | 1 |
| Oldman, PN | 1 |
| Labelle, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-Blind, Single-Dose Study to Assess the Pharmacodynamic Effects of SM-1 Versus Comparator and Placebo in a 5 Hour Phase Advance Model of Insomnia in Adults Who Suffer From Short-Term Insomnia[NCT02671760] | Phase 2 | 39 participants (Actual) | Interventional | 2016-02-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Safety and tolerability assessed in terms of the incidence of AEs (NCT02671760)
Timeframe: 8 hours
| Intervention | Number of Events (Number) |
|---|---|
| Treatment | 2 |
| Comparator | 3 |
| Placebo | 2 |
(NCT02671760)
Timeframe: 8 hours
| Intervention | Awakenings (Mean) |
|---|---|
| Treatment | 12.2 |
| Comparator | 11.0 |
| Placebo | 9.6 |
Time it takes to fall asleep (NCT02671760)
Timeframe: 8 hours
| Intervention | minutes (Mean) |
|---|---|
| Treatment | 31.2 |
| Comparator | 42.1 |
| Placebo | 50.1 |
Time required to achieve REM sleep (NCT02671760)
Timeframe: 8 hours
| Intervention | minutes (Mean) |
|---|---|
| Treatment | 112.5 |
| Comparator | 71.3 |
| Placebo | 61.2 |
Digit Symbol Substitution Test. The test score is number of correct answers in 90 seconds. Higher scores indicate favorable response (i.e., less residual sleepiness). The duration of the challenge is the 90 second time limit; there is no theoretical maximum score to attain. (NCT02671760)
Timeframe: 8 hours
| Intervention | Correct answers (Mean) |
|---|---|
| Treatment | 53.1 |
| Comparator | 53.3 |
| Placebo | 55.3 |
Karolinska Sleepiness Scale. This is a 9-point scale with values ranging from 1 (extremely alert) to 9 (extremely sleepy). Lower scores indicate less residual sleepiness. (NCT02671760)
Timeframe: 8 hours
| Intervention | Units on a scale (Mean) |
|---|---|
| Treatment | 5.8 |
| Comparator | 6.0 |
| Placebo | 6.1 |
(NCT02671760)
Timeframe: 8 hours
| Intervention | minutes (Mean) |
|---|---|
| Treatment | 382.9 |
| Comparator | 339.2 |
| Placebo | 256.2 |
2 reviews available for lorazepam and Sleep Initiation and Maintenance Disorders
| Article | Year |
|---|---|
Prazepam and lorazepam, two new benzodiazepines.
Topics: Administration, Oral; Anti-Anxiety Agents; Half-Life; Humans; Injections, Intramuscular; Injections, | 1978 |
Rebound insomnia and elimination half-life: assessment of individual subject response.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Dose-Response Relationship, D | 1985 |
42 trials available for lorazepam and Sleep Initiation and Maintenance Disorders
| Article | Year |
|---|---|
Efficacy of SM-1 in a transient insomnia model.
Topics: Adult; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Drug Combinations; Female; Humans; | 2019 |
Pilot study of lorazepam and tiagabine effects on sleep, motor learning, and impulsivity in cocaine abstinence.
Topics: Adult; Cocaine-Related Disorders; Cognition Disorders; Disruptive, Impulse Control, and Conduct Diso | 2008 |
Beneficial acute antidepressant effects of aripiprazole as an adjunctive treatment or monotherapy in bipolar patients unresponsive to mood stabilizers: results from a 16-week open-label trial.
Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Ag | 2008 |
Effectiveness of a cognitive behavioral self-help program for patients with primary insomnia in general practice - a pilot study.
Topics: Cognitive Behavioral Therapy; Combined Modality Therapy; Female; General Practice; Humans; Hypnotics | 2012 |
Trimipramine in primary insomnia: results of a polysomnographic double-blind controlled study.
Topics: Adult; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Benzodiazepines; Double-Blind Method; | 2002 |
A randomized clinical trial comparing doses and efficacy of lormetazepam tablets or oral solution for insomnia in a general practice setting.
Topics: Administration, Oral; Adult; Analysis of Variance; Family Practice; Female; Humans; Lorazepam; Male; | 2004 |
Comparison of lorazepam and zopiclone for insomnia in patients with stroke and brain injury: a randomized, crossover, double-blinded trial.
Topics: Administration, Oral; Adult; Aged; Attitude to Health; Azabicyclo Compounds; Brain Injuries; Cogniti | 2004 |
Lormetazepam in depressive insomnia: new evidence of phase-response effects of benzodiazepines.
Topics: Administration, Oral; Adult; Aged; Cross-Over Studies; Depressive Disorder; Drug Administration Sche | 2004 |
Next-day residual effects of hypnotics in DSM-IV primary insomnia: a driving simulator study with simultaneous electroencephalogram monitoring.
Topics: Adult; Arousal; Automobile Driving; Azabicyclo Compounds; Circadian Rhythm; Computer Simulation; Dia | 2005 |
High plasma concentrations of paroxetine impede clinical response in patients with panic disorder.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Asian People; Azepines; Diagnostic and Statis | 2007 |
Management of acute agitation in patients with bipolar disorder: efficacy and safety of intramuscular aripiprazole.
Topics: Acute Disease; Adult; Anti-Anxiety Agents; Antipsychotic Agents; Aripiprazole; Bipolar Disorder; Dis | 2007 |
Role of lormetazepam in the treatment of insomnia in the elderly.
Topics: Aged; Combined Modality Therapy; Female; Humans; Hypnotics and Sedatives; Lorazepam; Male; Sleep; Sl | 2007 |
Antidepressant medication treatment failure does not predict lower remission with ECT for major depressive disorder: a report from the consortium for research in electroconvulsive therapy.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Diagnostic and Statistical Manual of Menta | 2007 |
Efficacy and side effects of lorazepam, oxazepam, and temazepam as sleeping aids in psychogeriatric inpatients.
Topics: Aged; Anti-Anxiety Agents; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Lorazepam; | 1980 |
Lormetazepam - a benzodiazepine derivative without hangover effect? A double-blind study with chronic insomniacs in a general practice setting.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Electroe | 1981 |
Comparative efficacy of lormetazepam (Noctamid) and diazepam (Valium) in 100 out-patients with insomnia.
Topics: Adult; Aged; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Diazepam; Double-Blind | 1981 |
Benzodiazepine hypnotics remain effective for 24 weeks.
Topics: Adult; Aged; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Clinical Trials as Topic; Double-Blind M | 1982 |
[Comparison of lormetazepam and flunitrazepam in general practice (author's transl)].
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blin | 1982 |
[Double-blind comparison of lormetazepam and flurazepam in the treatment of patients with insomnia].
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blin | 1982 |
Lormetazepam and amobarbital sodium in the outpatient treatment of insomnia: a controlled trial.
Topics: Adult; Amobarbital; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Female; Humans; | 1983 |
Double-blind crossover comparison of triazolam and lorazepam in the posthypnotic state.
Topics: Adolescent; Adult; Akathisia, Drug-Induced; Anti-Anxiety Agents; Clinical Trials as Topic; Dizziness | 1984 |
The role of general practitioner research groups in the study of benzodiazepines.
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Anxiety; Clinical Trials as Topic; Clorazepate Dipotas | 1983 |
Sleep laboratory study of lormetazepam in older insomniacs.
Topics: Aged; Aging; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; El | 1984 |
Comparative study of lormetazepam and flurazepam in the treatment of insomnia.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Clinical Trials as Topic; Dose-Response Relati | 1984 |
Effects of lorazepam and its withdrawal on sleep, performance, and subjective state.
Topics: Adult; Anxiety; Female; Humans; Lorazepam; Male; Psychomotor Performance; Sleep Initiation and Maint | 1983 |
ECG activity in the sleep of insomniac patients under the influence of lormetazepam and zopiclone.
Topics: Aged; Anti-Anxiety Agents; Azabicyclo Compounds; Benzodiazepines; Electrocardiography; Female; Heart | 1995 |
Antagonizing the effects of experimentally induced sleep disturbance in healthy volunteers by lormetazepam and zolpidem.
Topics: Adult; Anti-Anxiety Agents; Attention; Benzodiazepines; Double-Blind Method; Female; Humans; Hypnoti | 1995 |
Multidrug comparison (lorazepam, triazolam, zolpidem, and zopiclone) in situational insomnia: polysomnographic analysis by means of the cyclic alternating pattern.
Topics: Adult; Azabicyclo Compounds; Female; Humans; Hypnotics and Sedatives; Lorazepam; Male; Middle Aged; | 1997 |
Nonorganic insomnia in generalized anxiety disorder. 2. Comparative studies on sleep, awakening, daytime vigilance and anxiety under lorazepam plus diphenhydramine (Somnium) versus lorazepam alone, utilizing clinical, polysomnographic and EEG mapping meth
Topics: Adult; Aged; Anti-Anxiety Agents; Anxiety Disorders; Arousal; Attention; Brain Mapping; Cerebral Cor | 1997 |
Comparative studies on the effects of the combination drug lorazepam plus diphenhydramine (Somnium) versus lorazepam on the noopsyche, thymopsyche and psychophysiology in nonorganic insomnia related to generalized anxiety disorder.
Topics: Adult; Aged; Anxiety Disorders; Diphenhydramine; Discriminant Analysis; Double-Blind Method; Drug Co | 1997 |
Amitriptyline vs. lorazepam in the treatment of opiate-withdrawal insomnia: a randomized double-blind study.
Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Double-Blind Method; Fe | 1998 |
The use of lorazepam TID for chronic insomnia.
Topics: Adult; Analysis of Variance; Chronic Disease; Female; Humans; Lorazepam; Male; Middle Aged; Psychomo | 1999 |
Hypnotic efficacy of lorazepam and flurazepam.
Topics: Anti-Anxiety Agents; Clinical Trials as Topic; Flurazepam; Humans; Lorazepam; Male; Sleep; Sleep Ini | 1976 |
[Lormetazepam in preoperative sleeplessness. Dose dependance of the effect and comparison with 100 mg pentobarbital (author's transl)].
Topics: Adult; Anti-Anxiety Agents; Female; Humans; Lorazepam; Male; Middle Aged; Pentobarbital; Preoperativ | 1979 |
Topographical analysis of sleep spindle activity.
Topics: Adult; Aged; Anti-Anxiety Agents; Azabicyclo Compounds; Benzodiazepines; Brain Mapping; Double-Blind | 1992 |
Pattern recognition by matched filtering: an analysis of sleep spindle and K-complex density under the influence of lormetazepam and zopiclone.
Topics: Adult; Aged; Anti-Anxiety Agents; Arousal; Azabicyclo Compounds; Benzodiazepines; Cerebral Cortex; D | 1992 |
Rebound insomnia and elimination half-life: assessment of individual subject response.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Dose-Response Relationship, D | 1985 |
Transfer of long term insomniac nitrazepam users to lormetazepam.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Benzodiazepines; Chronic Disease; Double-Blind Method; Femal | 1986 |
The effectiveness of oral midazolam as a hypnotic compared with lorazepam.
Topics: Administration, Oral; Adolescent; Adult; Aged; Benzodiazepines; Double-Blind Method; Drug Evaluation | 1986 |
Comparison of lorazepam and flurazepam as hypnotic agents in chronic insomniacs.
Topics: Adult; Arousal; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Electroencephalograp | 1988 |
A double-blind comparison of two lormetazepam doses in elderly insomniacs.
Topics: Aged; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Female; H | 1988 |
A comparative study of lormetazepam and chlormethiazole in elderly in-patients.
Topics: Aged; Aged, 80 and over; Aging; Anti-Anxiety Agents; Benzodiazepines; Chlormethiazole; Clinical Tria | 1987 |
17 other studies available for lorazepam and Sleep Initiation and Maintenance Disorders
| Article | Year |
|---|---|
Benzodiazepine abuse among athletes: Pain relief or just a weapon against insomnia? A clinical case study.
Topics: Adult; Athletes; Female; Humans; Lorazepam; Pain; Pain Management; Sleep; Sleep Initiation and Maint | 2019 |
Cycloid psychosis and its longitudinal diagnosis: case report.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Female; Haloperidol; Humans; Hypnotics and Sedat | 2020 |
Socio-demographic and clinical characteristics of benzodiazepine long-term users: Results from a tertiary care center.
Topics: Adult; Anxiety Disorders; Benzodiazepines; Dose-Response Relationship, Drug; Female; Humans; Long-Te | 2016 |
Microemulsion based intranasal delivery system for treatment of insomnia.
Topics: Administration, Intranasal; Alprazolam; Animals; Diazepam; Disease Models, Animal; Drug Compounding; | 2009 |
Choice of benzodiazepines.
Topics: Aged; Anti-Anxiety Agents; Anxiety; Chlordiazepoxide; Diazepam; Flurazepam; Half-Life; Humans; Liver | 1981 |
Benzodiazepine withdrawal.
Topics: Anti-Anxiety Agents; Anxiety; Diazepam; Drug Tolerance; Humans; Lorazepam; Oxazepam; Sleep Initiatio | 1981 |
Lorazepam-efficacy, side effects, and rebound phenomena.
Topics: Amnesia; Anti-Anxiety Agents; Humans; Lorazepam; Nausea; Sleep Initiation and Maintenance Disorders; | 1982 |
Daytime alertness, insomnia, and benzodiazepines.
Topics: Adult; Anti-Anxiety Agents; Arousal; Benzodiazepines; Double-Blind Method; Flurazepam; Humans; Loraz | 1982 |
[Our electroencephalographic data in the framework of a review on lormetazepam].
Topics: Adult; Aged; Anti-Anxiety Agents; Benzodiazepines; Electroencephalography; Female; Humans; Lorazepam | 1984 |
[Benzodiazepines: effects on sleep and on attention capacity the following day. Long-term study administration of lormetazepam and flurazepam].
Topics: Adult; Anti-Anxiety Agents; Attention; Benzodiazepines; Female; Flurazepam; Humans; Lorazepam; Male; | 1984 |
[Lormetazepam].
Topics: Anti-Anxiety Agents; Benzodiazepines; Drug Interactions; Humans; Kinetics; Lorazepam; Sleep Initiati | 1984 |
Insomnia and psychotropic drug consumption.
Topics: Adolescent; Adult; Age Distribution; Aged; Anxiety; Benzodiazepines; Bromazepam; Female; Humans; Lor | 1995 |
[Instead of benzodiazepines. An antidepressant as sleep aid].
Topics: Anti-Anxiety Agents; Antidepressive Agents; Benzodiazepines; Chronic Disease; Clinical Trials as Top | 2001 |
Lormetazepam (Loramet) in the elderly: an acceptability study.
Topics: Aged; Anti-Anxiety Agents; Benzodiazepines; Dreams; Drug Evaluation; Female; Humans; Lorazepam; Male | 1985 |
Tranquilizers and sedative/hypnotics: appropriate use in the elderly.
Topics: Aged; Alprazolam; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Half-Life; Humans; Hypnotics and Se | 1986 |
Manic-like reaction induced by lorazepam withdrawal.
Topics: Anxiety Disorders; Bipolar Disorder; Female; Humans; Lorazepam; Middle Aged; Sleep Initiation and Ma | 1987 |
Lorazepam: effects on sleep and withdrawal phenomena.
Topics: Adult; Humans; Lorazepam; Memory Disorders; Middle Aged; Sleep; Sleep Initiation and Maintenance Dis | 1986 |