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lorazepam and Neuroleptic Malignant Syndrome

lorazepam has been researched along with Neuroleptic Malignant Syndrome in 34 studies

Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.

Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)

Research Excerpts

ExcerptRelevanceReference
"A case of a male patient with schizophrenic illness who developed neuroleptic malignant syndrome (NMS) following treatment with olanzapine is reported."7.75Olanzapine-induced neuroleptic malignant syndrome in a patient with paranoid schizophrenia. ( Borkar, HA; Chandak, S; Srivastava, A, 2009)
"We present the case of a 14-year-old female who had many characteristics of neuroleptic malignant syndrome (NMS) without pyrexia following a single depot injection of 200 mg of zuclopenthixol."7.74Zuclopenthixol-induced neuroleptic malignant syndrome in an adolescent girl. ( Bildik, T; Ercan, ES; Erermis, S; Gockay, A; Karasoy, H; Tamar, M, 2007)
"Neuroleptic-induced catatonia is reported in an adolescent patient who responded successfully to lorazepam."4.78Neuroleptic-induced catatonia as a stage in the progression toward neuroleptic malignant syndrome. ( Woodbury, MA; Woodbury, MM, 1992)
"A case of a male patient with schizophrenic illness who developed neuroleptic malignant syndrome (NMS) following treatment with olanzapine is reported."3.75Olanzapine-induced neuroleptic malignant syndrome in a patient with paranoid schizophrenia. ( Borkar, HA; Chandak, S; Srivastava, A, 2009)
"We present the case of a 14-year-old female who had many characteristics of neuroleptic malignant syndrome (NMS) without pyrexia following a single depot injection of 200 mg of zuclopenthixol."3.74Zuclopenthixol-induced neuroleptic malignant syndrome in an adolescent girl. ( Bildik, T; Ercan, ES; Erermis, S; Gockay, A; Karasoy, H; Tamar, M, 2007)
"An adult schizophrenic patient developed neuroleptic malignant syndrome following treatment with parenteral haloperidol."3.68Neuroleptic malignant syndrome (a case report). ( Patkar, AA; Shah, LP, 1991)
"Catatonia is a distinct neuropsychiatric syndrome that is becoming more recognized clinically and in ongoing research."2.46Catatonia: diagnosis, classification, and treatment. ( Francis, A, 2010)
"In the first, catatonia was described as an under-recognized syndrome with a potentially fatal outcome."2.40Catatonia. 2: Diagnosis, management and prognosis. ( Clark, T; Rickards, H, 1999)
"While neuroleptic malignant syndrome (NMS) is typically characterised by delirium, motor rigidity, fever and dysautonomia, the syndrome is not pathognomonic, and NMS remains a diagnosis of exclusion."1.51Neuroleptic malignant syndrome: a concealed diagnosis with multitreatment approach. ( Barahona-Corrêa, JB; Neves, A; Oliveira-Maia, AJ; Velosa, A, 2019)
"Malignant catatonia is a severe form of catatonia which is acute in onset, and is systemically devastating, as it is associated with fever and autonomic instability."1.35Electroconvulsive therapy for malignant catatonia in adolescence. ( Burt, L; Dhossche, DM; Kumar, T; Shettar, SM, 2009)
"Two patients with the neuroleptic malignant syndrome (NMS), a man aged 31 years and a woman aged 83 years, were referred for electroconvulsive therapy after 70 and 7 days, respectively."1.33[Neuroleptic malignant syndrome: a life-threatening complication that can be treated effectively]. ( Muller, ME; van Waarde, JA; Verweg, B, 2006)
"Lorazepam was used as initial treatment, which provided significant improvement."1.32A malignant neuroleptic spectrum: review of diagnostic criteria and treatment implications in three case reports. ( Pandya, M; Pozuelo, L, 2004)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.94)18.7374
1990's8 (23.53)18.2507
2000's16 (47.06)29.6817
2010's8 (23.53)24.3611
2020's1 (2.94)2.80

Authors

AuthorsStudies
Fernandez, A1
Pendaries, G1
Dor, E1
Askenazy, F1
Thümmler, S1
Das, S1
Purushothaman, ST1
Bc, M1
Chatterjee, SS1
Kartha, A1
Rajan, V1
Hardman, MI1
Sprung, J1
Weingarten, TN1
Velosa, A1
Neves, A1
Barahona-Corrêa, JB1
Oliveira-Maia, AJ1
Lopez, E1
Fraile, S1
Hidalgo, FJ1
García, B1
Verma, R1
Junewar, V1
Rathaur, BP1
Guru, S1
Vanamoorthy, U1
Loganathan, S1
Varghese, M1
Rosebush, PI1
Anglin, RE1
Richards, C1
Mazurek, MF1
Srivastava, A1
Borkar, HA1
Chandak, S1
Brantley, E1
Cohn, J1
Babu, K1
Ghio, L1
Fornaro, G1
Rossi, P1
Dhossche, DM1
Shettar, SM1
Kumar, T1
Burt, L1
Francis, A1
Coffey, MJ1
Chakraborty, N1
Johnston, T1
Pandya, M1
Pozuelo, L1
Mendhekar, DN1
Jiloha, RC1
Hammerman, S1
Lam, C1
Caroff, SN2
van Waarde, JA1
Muller, ME1
Verweg, B1
Erermis, S1
Bildik, T1
Tamar, M1
Gockay, A1
Karasoy, H1
Ercan, ES1
Strawn, JR1
Keck, PE1
Khan, KH1
Tham, TC1
Singh, D1
Forlano, R1
Athey, R1
Real Rodríguez, B1
Ruibal, JL1
Grande Rodríguez, S1
Sueiro Pita, B1
Fink, M1
Lausberg, H1
Hellweg, R1
Clark, T1
Rickards, H1
Duggal, HS1
Hatch, CD1
Lund, BC1
Perry, PJ1
Woodbury, MM1
Woodbury, MA1
Weller, M1
Patkar, AA1
Shah, LP1
Chandler, JD1
Ryken, TC1
Merrell, AN1

Reviews

6 reviews available for lorazepam and Neuroleptic Malignant Syndrome

ArticleYear
Acute phenibut withdrawal: A comprehensive literature review and illustrative case report.
    Bosnian journal of basic medical sciences, 2019, May-20, Volume: 19, Issue:2

    Topics: Akathisia, Drug-Induced; Baclofen; Cyproheptadine; Dexmedetomidine; Diphenhydramine; GABA-A Receptor

2019
Catatonia: diagnosis, classification, and treatment.
    Current psychiatry reports, 2010, Volume: 12, Issue:3

    Topics: Anticonvulsants; Catatonia; Diagnosis, Differential; Diagnostic and Statistical Manual of Mental Dis

2010
Neuroleptic malignant syndrome.
    The American journal of psychiatry, 2007, Volume: 164, Issue:6

    Topics: Adult; Amantadine; Antiparkinson Agents; Antipsychotic Agents; Benzodiazepines; Bromocriptine; Dantr

2007
[The neuroleptic malignant syndrome in an adolescent. Its treatment with dantrolene, bromocryptin and diazepam].
    Anales espanoles de pediatria, 1996, Volume: 44, Issue:1

    Topics: Adolescent; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Antiparkinson Agents; Antipsychot

1996
Catatonia. 2: Diagnosis, management and prognosis.
    Hospital medicine (London, England : 1998), 1999, Volume: 60, Issue:11

    Topics: Benzodiazepines; Catatonia; Diagnosis, Differential; Electroconvulsive Therapy; Humans; Hypnotics an

1999
Neuroleptic-induced catatonia as a stage in the progression toward neuroleptic malignant syndrome.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1992, Volume: 31, Issue:6

    Topics: Adolescent; Catatonia; Drug Therapy, Combination; Haloperidol; Humans; Lorazepam; Male; Neuroleptic

1992

Other Studies

28 other studies available for lorazepam and Neuroleptic Malignant Syndrome

ArticleYear
[Malignant neuroleptic syndrome: An atypical case in an adolescent affected by bipolar I disorder associated with catatonic syndrome].
    L'Encephale, 2020, Volume: 46, Issue:2

    Topics: Adolescent; Antipsychotic Agents; Bipolar Disorder; Catatonia; Electroencephalography; Humans; Hypno

2020
Oral Asenapine overdose leading to Neuroleptic Malignant Syndrome (NMS).
    Asian journal of psychiatry, 2017, Volume: 30

    Topics: Administration, Oral; Adult; Antipsychotic Agents; Bromocriptine; Diagnosis, Differential; Dibenzocy

2017
Neuroleptic malignant syndrome: a concealed diagnosis with multitreatment approach.
    BMJ case reports, 2019, Jun-17, Volume: 12, Issue:6

    Topics: Acute Kidney Injury; Adult; Anticonvulsants; Antipsychotic Agents; Bromocriptine; Diagnosis, Differe

2019
[Possible malignant neuroleptic syndrome associated with aripiprazole and imipramine and treated with bromocriptine].
    Medicina clinica, 2013, Sep-21, Volume: 141, Issue:6

    Topics: Antipsychotic Agents; Aripiprazole; Bromocriptine; Combined Modality Therapy; Drug Therapy, Combinat

2013
An atypical case of neuroleptic malignant syndrome precipitated by valproate.
    BMJ case reports, 2014, Mar-06, Volume: 2014

    Topics: Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Benzothiazoles; Dopamine Agonists; Drug Ther

2014
Neuroleptic malignant syndrome following abrupt anti-cholinergic withdrawal: a case report.
    Asian journal of psychiatry, 2014, Volume: 12

    Topics: Antipsychotic Agents; Cholinergic Antagonists; Female; Humans; Lorazepam; Neuroleptic Malignant Synd

2014
Neuroleptic malignant syndrome and the acute phase response.
    Journal of clinical psychopharmacology, 2008, Volume: 28, Issue:4

    Topics: Acute-Phase Proteins; Acute-Phase Reaction; Adolescent; GABA Modulators; Humans; Lorazepam; Male; Ne

2008
Olanzapine-induced neuroleptic malignant syndrome in a patient with paranoid schizophrenia.
    Psychiatry and clinical neurosciences, 2009, Volume: 63, Issue:1

    Topics: Antipsychotic Agents; Benzodiazepines; Consciousness; Humans; Hypnotics and Sedatives; Lorazepam; Ma

2009
Case files of the program in medical toxicology at brown university: amantadine withdrawal and the neuroleptic malignant syndrome.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2009, Volume: 5, Issue:2

    Topics: Amantadine; Antipsychotic Agents; Diagnosis, Differential; Drug Therapy, Combination; Female; Fluid

2009
Risperidone-induced hyperamylasemia, hyperlipasemia, and neuroleptic malignant syndrome: a case report.
    Journal of clinical psychopharmacology, 2009, Volume: 29, Issue:4

    Topics: Antipsychotic Agents; Female; Humans; Hyperamylasemia; Injections, Intramuscular; Intubation, Gastro

2009
Electroconvulsive therapy for malignant catatonia in adolescence.
    Southern medical journal, 2009, Volume: 102, Issue:11

    Topics: Adolescent; Anti-Anxiety Agents; Catatonia; Diagnosis, Differential; Electroconvulsive Therapy; Huma

2009
Catatonia and encephalopathy associated with paliperidone palmitate.
    Journal of clinical psychopharmacology, 2012, Volume: 32, Issue:2

    Topics: Aged; Antipsychotic Agents; Catatonia; Female; Humans; Isoxazoles; Lorazepam; Male; Neuroleptic Mali

2012
Aripiprazole and neuroleptic malignant syndrome.
    International clinical psychopharmacology, 2004, Volume: 19, Issue:6

    Topics: Adult; Antipsychotic Agents; Aripiprazole; Dose-Response Relationship, Drug; Humans; Lorazepam; Male

2004
A malignant neuroleptic spectrum: review of diagnostic criteria and treatment implications in three case reports.
    International journal of psychiatry in medicine, 2004, Volume: 34, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Diagnosis, Differential; Female; GABA Modulators; Humans; Lorazepam;

2004
Neuroleptic malignant syndrome precipitated by haloperidol following clozapine discontinuation.
    The Australian and New Zealand journal of psychiatry, 2005, Volume: 39, Issue:10

    Topics: Adult; Anti-Anxiety Agents; Antiparkinson Agents; Antipsychotic Agents; Bromocriptine; Clozapine; Cr

2005
Neuroleptic malignant syndrome and aripiprazole.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2006, Volume: 45, Issue:6

    Topics: Adolescent; Anti-Anxiety Agents; Antipsychotic Agents; Aripiprazole; Depressive Disorder; Female; Hu

2006
[Neuroleptic malignant syndrome: a life-threatening complication that can be treated effectively].
    Nederlands tijdschrift voor geneeskunde, 2006, Nov-18, Volume: 150, Issue:46

    Topics: Adult; Aged, 80 and over; Electroconvulsive Therapy; Female; Humans; Hypnotics and Sedatives; Loraze

2006
Zuclopenthixol-induced neuroleptic malignant syndrome in an adolescent girl.
    Clinical toxicology (Philadelphia, Pa.), 2007, Volume: 45, Issue:3

    Topics: Adolescent; Anti-Anxiety Agents; Antidotes; Antipsychotic Agents; Bromocriptine; Clopenthixol; Delay

2007
Neuroleptic malignant syndrome induced by quetiapine overdose.
    British journal of hospital medicine (London, England : 2005), 2008, Volume: 69, Issue:3

    Topics: Acetaminophen; Antidotes; Antipsychotic Agents; Dibenzothiazepines; Drug Overdose; Female; Humans; L

2008
Neuroleptic malignant syndrome and catatonia in a patient with dementia.
    The Australian and New Zealand journal of psychiatry, 2008, Volume: 42, Issue:6

    Topics: Aged; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Catatonia; Chlorpromazine; Choline

2008
Toxic serotonin syndrome or neuroleptic malignant syndrome?
    Pharmacopsychiatry, 1996, Volume: 29, Issue:4

    Topics: Antidepressive Agents, Tricyclic; Central Nervous System Diseases; Electroconvulsive Therapy; Female

1996
["Catatonic dilemma". Therapy with lorazepam and clozapine].
    Der Nervenarzt, 1998, Volume: 69, Issue:9

    Topics: Adult; Anti-Anxiety Agents; Antipsychotic Agents; Clozapine; Diagnosis, Differential; Drug Therapy,

1998
Neuroleptic malignant syndrome precipitated by promethazine and lorazepam.
    The Australian and New Zealand journal of psychiatry, 2001, Volume: 35, Issue:2

    Topics: Adolescent; Anticonvulsants; Antipsychotic Agents; Basal Ganglia Diseases; Histamine H1 Antagonists;

2001
Failed challenge with quetiapine after neuroleptic malignant syndrome with conventional antipsychotics.
    Pharmacotherapy, 2001, Volume: 21, Issue:8

    Topics: Alzheimer Disease; Antipsychotic Agents; Chlorpromazine; Dibenzothiazepines; Haloperidol; Humans; Hy

2001
NMS and lethal catatonia.
    The Journal of clinical psychiatry, 1992, Volume: 53, Issue:8

    Topics: Catatonia; Clozapine; Diagnosis, Differential; Humans; Lorazepam; Neuroleptic Malignant Syndrome

1992
Neuroleptic malignant syndrome (a case report).
    Journal of postgraduate medicine, 1991, Volume: 37, Issue:3

    Topics: Adult; Bromocriptine; Female; Haloperidol; Humans; Lorazepam; Neuroleptic Malignant Syndrome

1991
Psychogenic catatonia with elevated creatine kinase and autonomic hyperactivity.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1991, Volume: 36, Issue:7

    Topics: Adult; Arousal; Autonomic Nervous System; Catatonia; Combined Modality Therapy; Creatine Kinase; Del

1991
Haloperidol-induced neuroleptic malignant syndrome in a 67-year-old woman with parkinsonism.
    The Western journal of medicine, 1989, Volume: 151, Issue:3

    Topics: Aged; Female; Haloperidol; Humans; Lorazepam; Neuroleptic Malignant Syndrome; Parkinson Disease

1989