lorazepam has been researched along with Metabolic Acidosis in 13 studies
Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Citalopram, a newer generation SSRI, is commonly prescribed, but despite its low toxicity profile has a potential to cause seizures and dysarrythmias in overdose." | 7.76 | Metabolic acidosis and generalized seizures secondary to citalopram overdose: a case report. ( Al Anazi, T; Al Hayyan, H; Al Hussein, M; Al Modaimegh, H; Al Qahtani, M; Bin Salih, S, 2010) |
| " He received a high-dose lorazepam infusion for alcohol withdrawal during hospitalization and developed severe hyperosmolality, high anion gap metabolic acidosis, and acute kidney injury on his eighth day of hospitalization." | 7.74 | Acute kidney injury, hyperosmolality and metabolic acidosis associated with lorazepam. ( Graeber, C; Sullivan, A; Yusufzai, I; Zar, T, 2007) |
| " Serum propylene glycol concentrations were drawn at 48 hrs into the high-dose lorazepam infusion, and the presence of propylene glycol accumulation, as evidenced by a high anion gap (> or =15 mmol/L) metabolic acidosis with elevated osmol gap (> or =10 mOsm/L), was assessed at that time." | 5.11 | Relationship of continuous infusion lorazepam to serum propylene glycol concentration in critically ill adults. ( Arroliga, AC; Gonzales, JP; McCarthy, K; Shehab, N, 2004) |
| "While some case reports indicate that high doses of propylene glycol (PG) may result in metabolic acidosis, there has been no large-scale study that evaluated the risk of metabolic acidosis in patients receiving PG-containing benzodiazepines for acute alcohol withdrawal." | 3.88 | Assessing Propylene Glycol Toxicity in Alcohol Withdrawal Patients Receiving Intravenous Benzodiazepines: A One-Compartment Pharmacokinetic Model. ( Bodreau, C; Elbarbry, F; Farthing, K; Jahn, A, 2018) |
| " Citalopram, a newer generation SSRI, is commonly prescribed, but despite its low toxicity profile has a potential to cause seizures and dysarrythmias in overdose." | 3.76 | Metabolic acidosis and generalized seizures secondary to citalopram overdose: a case report. ( Al Anazi, T; Al Hayyan, H; Al Hussein, M; Al Modaimegh, H; Al Qahtani, M; Bin Salih, S, 2010) |
| " He received a high-dose lorazepam infusion for alcohol withdrawal during hospitalization and developed severe hyperosmolality, high anion gap metabolic acidosis, and acute kidney injury on his eighth day of hospitalization." | 3.74 | Acute kidney injury, hyperosmolality and metabolic acidosis associated with lorazepam. ( Graeber, C; Sullivan, A; Yusufzai, I; Zar, T, 2007) |
| "A 37-year-old woman presented with coma unresponsive to naloxone following topiramate ingestion." | 1.36 | Clinical effects and toxicokinetic evaluation following massive topiramate ingestion. ( Krasowski, MD; Lynch, MJ; Pizon, AF; Siam, MG, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 7 (53.85) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jahn, A | 1 |
| Bodreau, C | 1 |
| Farthing, K | 1 |
| Elbarbry, F | 1 |
| Lynch, MJ | 1 |
| Pizon, AF | 1 |
| Siam, MG | 1 |
| Krasowski, MD | 1 |
| Yan, MT | 1 |
| Chau, T | 1 |
| Cheng, CJ | 1 |
| Lin, SH | 1 |
| Fung, EC | 1 |
| Crook, MA | 1 |
| Bin Salih, S | 1 |
| Al Qahtani, M | 1 |
| Al Anazi, T | 1 |
| Al Hussein, M | 1 |
| Al Hayyan, H | 1 |
| Al Modaimegh, H | 1 |
| Mullins, ME | 1 |
| Barnes, BJ | 1 |
| Arroliga, AC | 1 |
| Shehab, N | 1 |
| McCarthy, K | 1 |
| Gonzales, JP | 1 |
| Bouchard, NC | 1 |
| Fulton, JA | 1 |
| Hoffman, RS | 1 |
| Zar, T | 1 |
| Yusufzai, I | 1 |
| Sullivan, A | 1 |
| Graeber, C | 1 |
| Parmar, MS | 1 |
| Tsao, YT | 1 |
| Tsai, WC | 1 |
| Yang, SP | 1 |
| Arbour, RB | 1 |
| Tayar, J | 1 |
| Jabbour, G | 1 |
| Saggi, SJ | 1 |
1 trial available for lorazepam and Metabolic Acidosis
| Article | Year |
|---|---|
Relationship of continuous infusion lorazepam to serum propylene glycol concentration in critically ill adults.
Topics: Acid-Base Equilibrium; Acidosis; Adult; Critical Illness; Dose-Response Relationship, Drug; Female; | 2004 |
12 other studies available for lorazepam and Metabolic Acidosis
| Article | Year |
|---|---|
Assessing Propylene Glycol Toxicity in Alcohol Withdrawal Patients Receiving Intravenous Benzodiazepines: A One-Compartment Pharmacokinetic Model.
Topics: Acid-Base Equilibrium; Acidosis; Alcoholism; Benzodiazepines; Diazepam; Female; Humans; Injections, | 2018 |
Clinical effects and toxicokinetic evaluation following massive topiramate ingestion.
Topics: Acidosis; Adult; Anticonvulsants; Bipolar Disorder; Blood Gas Analysis; Coma; Critical Care; Drug Ov | 2010 |
Hunting down a double gap metabolic acidosis.
Topics: Acidosis; Aged; Alcoholism; Fatal Outcome; Female; Humans; Kidney Failure, Chronic; Lorazepam; Pneum | 2010 |
Closing in on the gaps.
Topics: Acidosis; Aged; Alcoholism; Female; Humans; Kidney Failure, Chronic; Lorazepam; Pneumonia, Ventilato | 2010 |
Metabolic acidosis and generalized seizures secondary to citalopram overdose: a case report.
Topics: Acidosis; Anticonvulsants; Citalopram; Depression; Drug Overdose; Female; Humans; Lorazepam; Seizure | 2010 |
Hyperosmolar metabolic acidosis and intravenous Lorazepam.
Topics: Acidosis; Humans; Infusions, Intravenous; Lorazepam; Osmolar Concentration; Pharmaceutical Vehicles; | 2002 |
Propylene glycol accumulation after high-dose lorazepam: what have we learned?
Topics: Acid-Base Equilibrium; Acidosis; Critical Illness; Humans; Hypnotics and Sedatives; Infusions, Intra | 2005 |
Acute kidney injury, hyperosmolality and metabolic acidosis associated with lorazepam.
Topics: Acidosis; Acute Kidney Injury; Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Drug Compounding; H | 2007 |
Re: Acute kidney injury, hyperosmolality and metabolic acidosis associated with lorazepam.
Topics: Acidosis; Acute Kidney Injury; Anti-Anxiety Agents; Drug Compounding; Humans; Lorazepam; Osmolar Con | 2007 |
A life-threatening double gap metabolic acidosis.
Topics: Acidosis; Alcoholism; Diagnosis, Differential; Humans; Hypnotics and Sedatives; Lorazepam; Male; Mid | 2008 |
Propylene glycol toxicity related to high-dose lorazepam infusion: case report and discussion.
Topics: Acidosis; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Lorazepam; Male; Metabolic Cleara | 1999 |
Severe hyperosmolar metabolic acidosis due to a large dose of intravenous lorazepam.
Topics: Acidosis; Adult; Female; Humans; Infusions, Intravenous; Lorazepam; Osmolar Concentration; Oxidation | 2002 |