Page last updated: 2024-10-30

lorazepam and Hypertension

lorazepam has been researched along with Hypertension in 14 studies

Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.

Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Research Excerpts

ExcerptRelevanceReference
"Sixty-two adults with a current diagnosis of significant hypertension and accompanying moderate to severe anxiety were medicated with lorazepam or with placebo for a period of 4 weeks."9.04The effect of lorazepam on hypertension-associated anxiety: a double-blind study. ( Hart, WL; Parmley, LF, 1978)
"Sixty-two adults with a current diagnosis of significant hypertension and accompanying moderate to severe anxiety were medicated with lorazepam or with placebo for a period of 4 weeks."5.04The effect of lorazepam on hypertension-associated anxiety: a double-blind study. ( Hart, WL; Parmley, LF, 1978)
" The case presentation illustrates the role of pregabalin in successful medical management of this chronic pain disorder, as well as the management of common psychiatric morbidities associated with this condition."3.74Pregabalin-induced remission in a 62-year-old woman with a 20-year history of vulvodynia. ( Jerome, L, 2007)
" A reduction in the dosage of benzodiazepines in the setting of epileptic patients with predominant autonomic symptoms may need to be considered."1.37Benzodiazepines in the acute management of seizures with autonomic manifestations: anticipate complications! ( Fluss, J; Gervaix, A; Korff, CM; Lacroix, L, 2011)
"We report a case of gamma-hydroxybutyrate (GHB) withdrawal resulting in severe agitation, mental status changes, elevated blood pressure, and tachycardia hours after stopping chronic use of GHB."1.31Severe gamma-hydroxybutyrate withdrawal: a case report and literature review. ( Bania, TC; Craig, K; Gomez, HF; McManus, JL, 2000)
"Lorazepam was an effective sedative and anxiolytic by either route, and there were no eclamptic fits among the lorazepam-treated patients."1.26Effect of maternal lorazepam on the neonate. ( Cummings, AJ; McFadyen, IR; Whitelaw, AG, 1981)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19903 (21.43)18.7374
1990's1 (7.14)18.2507
2000's7 (50.00)29.6817
2010's2 (14.29)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Gouse, BM1
Spears, WE1
Nieves Archibald, A1
Montalvo, C1
Shah, P1
McDowell, M1
Ebisu, R1
Hanif, T1
Toerne, T1
Marchione, P1
Vento, C1
Marianetti, M1
Romeo, T1
Amabile, GA1
Giacomini, P1
Lacroix, L1
Fluss, J1
Gervaix, A1
Korff, CM1
Maccioli, GA1
Zeller, A1
Handschin, D1
Gyr, N1
Martina, B1
Battegay, E1
Rezvani, M1
Hartfield, D1
Jerome, L1
Smolinske, SC1
Rastogi, R1
Schenkel, S1
Whitelaw, AG2
Cummings, AJ2
McFadyen, IR1
Deckert, J1
Przuntek, H1
Gleiter, CH1
Craig, K1
Gomez, HF1
McManus, JL1
Bania, TC1
Hart, WL1
Parmley, LF1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Dexmedetomidine (Precedex®), With Lorazepam Rescue, for the Management of Severe Alcohol Withdrawal Syndrome (AWS) and Alcohol Withdrawal Delirium (AWD)[NCT01362205]Phase 449 participants (Actual)Interventional2012-03-31Terminated (stopped due to DSMB recommendation for slow enrollment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Average MINDS Score

Minnesota Detoxification Scale (MINDS) min score 0, max score 46. The higher the score, the worse the symptoms of AWS/AWD. (NCT01362205)
Timeframe: up to 28 days

Interventionunits on a scale (Median)
Dexmedetomidine8.2
Placebo9.4

Number of Ventilator Free Days After Randomization.

A ventilator day is counted for any use of invasive mechanical ventilation during a calendar day (NCT01362205)
Timeframe: up to 28 days

Interventiondays (Median)
Dexmedetomidine27.5
Placebo28.0

Resource Utilization Costs Associated With This Hospitalization Billed by Facility.

(NCT01362205)
Timeframe: Up to 28 days

InterventionUSD (Median)
Dexmedetomidine81234
Placebo91651

Resource Utilization Costs Associated With This Hospitalization Billed by Physicians.

(NCT01362205)
Timeframe: up to 28 Days

InterventionDollar (United States) (Median)
Dexmedetomidine3482
Placebo4461

Scores at Hospital Discharge on the Beck Anxiety Inventory

The Beck Anxiety Inventory is a validated questionnaire used to measure severity of anxiety (min score 0, max score 63). The higher the score the greater the severity of anxiety. A score of 30-63 indicates severe anxiety, 17-29 moderate anxiety, 10-16 mild anxiety and 0-9 minimal anxiety. (NCT01362205)
Timeframe: Up to 28 days.

Interventionunits on a scale (Mean)
Dexmedetomidine30.3
Placebo21.6

Scores at Hospital Discharge on the Beck Depression Inventory.

The Beck Depression Inventory is a validated questionnaire used to measure severity of depression (min score 0, max score 63). The higher the score the greater the severity of depression. A score of 30-63 indicates severe depression, 19-29 moderate depression, 10-18 mild depression and 0-9 minimal depression. (NCT01362205)
Timeframe: Up to 28 days.

Interventionunits on a scale (Mean)
Dexmedetomidine26.5
Placebo21.4

Scores at Hospital Discharge on the Mini Mental Exam.

The Mini Mental State Examination or Folstein test is a validated 30-point questionnaire used to measure cognitive impairment (min score 0, max score 30). A score of 24 points (out of a max of 30) indicates normal cognition, less than or equal to 9 points indicates severe impairment, 10-18 indicates moderate impairment and 19-23 mild impairment. (NCT01362205)
Timeframe: up to 28 days

Interventionunits on a scale (Mean)
Dexmedetomidine25.8
Placebo23.1

Scores at Hospital Discharge on the PTSD Civilian Checklist

PTSD checklist consists of 17 questions graded on a scale of 1 to 5. The PTSD score is comprised from the sum of the scores 17 questions. The PTSD score has possible values from to 17 to 85 with higher values indicating greater symptom severity. (NCT01362205)
Timeframe: Up to 28 days

Interventionunits on a scale (Median)
Dexmedetomidine45.5
Placebo32.5

The Length in Days of the Hospital Stay

A hospital day is counted for any time on a calendar day the patient is admitted to the hospital. Hospital days are inclusive of ICU days. (NCT01362205)
Timeframe: up to 28 days

Interventiondays (Median)
Dexmedetomidine8.0
Placebo12.0

The Length of ICU Stay Defined as the Time Between Randomization and ICU Transfer Orders.

(NCT01362205)
Timeframe: up to 28 days in hours

Interventionhours (Median)
Dexmedetomidine79.2
Placebo104.9

The Number of CAM-ICU Negative Days After Randomization.

The Confusion Assessment Method (CAM)-ICU is a validated instrument used to detect the presence or absence of delirium in the ICU. A delirium free day is counted for any day a patient is negative by the CAM-ICU. The higher the number of CAM-ICU negative days indicates the more days a patient was able to think clearly. (NCT01362205)
Timeframe: up to 28 days

Interventiondays (Median)
Dexmedetomidine0.3
Placebo0.3

Trials

1 trial available for lorazepam and Hypertension

ArticleYear
The effect of lorazepam on hypertension-associated anxiety: a double-blind study.
    The Journal of clinical psychiatry, 1978, Volume: 39, Issue:10 Pt 2

    Topics: Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Drug Evaluation; Female; Humans; Hypertens

1978

Other Studies

13 other studies available for lorazepam and Hypertension

ArticleYear
Catatonia in a hospitalized patient with COVID-19 and proposed immune-mediated mechanism.
    Brain, behavior, and immunity, 2020, Volume: 89

    Topics: Aged; Atrial Fibrillation; Basal Ganglia; Betacoronavirus; C-Reactive Protein; Catatonia; Coronaviru

2020
Adjunctive Use of Ketamine for Benzodiazepine-Resistant Severe Alcohol Withdrawal: a Retrospective Evaluation.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2018, Volume: 14, Issue:3

    Topics: Adult; Aged; Alcohol Withdrawal Seizures; Benzodiazepines; Blood Alcohol Content; Central Nervous Sy

2018
Hemiballismus in subthalamic haemorrhage: efficacy of levetiracetam.
    European journal of neurology, 2009, Volume: 16, Issue:6

    Topics: Aged; Anti-Dyskinesia Agents; Anticonvulsants; Antihypertensive Agents; Ataxia; Cerebellum; Dose-Res

2009
Benzodiazepines in the acute management of seizures with autonomic manifestations: anticipate complications!
    Epilepsia, 2011, Volume: 52, Issue:10

    Topics: Autonomic Nervous System Diseases; Benzodiazepines; Child; Child, Preschool; Diazepam; Female; Human

2011
Dexmedetomidine to facilitate drug withdrawal.
    Anesthesiology, 2003, Volume: 98, Issue:2

    Topics: Alcohol Drinking; Blood Pressure; Cocaine-Related Disorders; Dexmedetomidine; Female; Heart Rate; Hu

2003
Blood pressure and heart rate of students undergoing a medical licensing examination.
    Blood pressure, 2004, Volume: 13, Issue:1

    Topics: Adrenergic beta-Antagonists; Adult; Antidepressive Agents; Anxiety; Blood Pressure; Educational Meas

2004
Cocaine toxicity after laryngoscopy in an infant.
    The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique, 2006,Summer, Volume: 13, Issue:2

    Topics: Administration, Topical; Anesthetics, Local; Cocaine; Humans; Hypertension; Infant; Laryngoscopy; Lo

2006
Pregabalin-induced remission in a 62-year-old woman with a 20-year history of vulvodynia.
    Pain research & management, 2007,Autumn, Volume: 12, Issue:3

    Topics: Amitriptyline; Analgesics; Anti-Ulcer Agents; Anticoagulants; Antidepressive Agents; Anxiety; Cardio

2007
Foxy methoxy: a new drug of abuse.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2005, Volume: 1, Issue:1

    Topics: 5-Methoxytryptamine; Adult; Anti-Anxiety Agents; Catalepsy; Emergency Medical Services; Hallucinatio

2005
Effect of maternal lorazepam on the neonate.
    British medical journal (Clinical research ed.), 1981, Apr-04, Volume: 282, Issue:6270

    Topics: Anti-Anxiety Agents; Apgar Score; Body Temperature; Female; Fetal Blood; Humans; Hypertension; Infan

1981
A study of conjugation and drug elimination in the human neonate.
    British journal of clinical pharmacology, 1981, Volume: 12, Issue:4

    Topics: Anti-Anxiety Agents; Female; Humans; Hypertension; Infant, Newborn; Lorazepam; Male; Maternal-Fetal

1981
Organic anxiety syndrome after withdrawal of atenolol.
    The American journal of psychiatry, 1994, Volume: 151, Issue:12

    Topics: Aged; Anxiety Disorders; Atenolol; Diltiazem; Humans; Hypertension; Lorazepam; Male; Substance Withd

1994
Severe gamma-hydroxybutyrate withdrawal: a case report and literature review.
    The Journal of emergency medicine, 2000, Volume: 18, Issue:1

    Topics: Adult; Akathisia, Drug-Induced; Anti-Anxiety Agents; Autonomic Nervous System Diseases; Emergencies;

2000