lorazepam has been researched along with Epilepsy in 30 studies
Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lorazepam was compared with diazepam for the treatment of acute convulsions and status epilepticus in 102 children in a prospective, open, 'odd and even dates' trial." | 9.08 | Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus. ( Appleton, R; Choonara, I; Molyneux, E; Robson, J; Sweeney, A, 1995) |
| "Patients prescribed sublingual lorazepam solution at the Johns Hopkins Epilepsy Center for acute seizure treatment during a 5-year period (2012-2017) were screened." | 8.31 | Sublingual lorazepam as rescue therapy for seizure emergencies in adults. ( Krauss, GL; Lelis, IR, 2023) |
| "The objective of the study was to compare the performance of intravenous (IV) lorazepam (IVL) and intranasal midazolam (INM) for seizure termination and prevention of seizure clusters in adults admitted to the epilepsy monitoring unit (EMU) in whom seizures were captured on continuous video-electroencephalogram." | 7.91 | Comparison of intranasal midazolam versus intravenous lorazepam for seizure termination and prevention of seizure clusters in the adult epilepsy monitoring unit. ( Bautista, C; Cotugno, S; Deng, Y; Dhakar, MB; Farooque, P; Hirsch, LJ; Maciel, CB; McKimmy, D; Owusu, KA; Sukumar, N, 2019) |
| " lorazepam (LZP) in patients with epilepsy undergoing evaluation in an epilepsy monitoring unit (EMU) who experienced seizures requiring acute treatment." | 5.34 | Randomized open-label trial of intravenous brivaracetam versus lorazepam for acute treatment of increased seizure activity. ( Greve, B; Moseley, BD; Sadek, A; Szaflarski, JP; Varner, JA; Williams, P, 2020) |
| "Lorazepam was compared with diazepam for the treatment of acute convulsions and status epilepticus in 102 children in a prospective, open, 'odd and even dates' trial." | 5.08 | Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus. ( Appleton, R; Choonara, I; Molyneux, E; Robson, J; Sweeney, A, 1995) |
| "Patients prescribed sublingual lorazepam solution at the Johns Hopkins Epilepsy Center for acute seizure treatment during a 5-year period (2012-2017) were screened." | 4.31 | Sublingual lorazepam as rescue therapy for seizure emergencies in adults. ( Krauss, GL; Lelis, IR, 2023) |
| "The objective of the study was to compare the performance of intravenous (IV) lorazepam (IVL) and intranasal midazolam (INM) for seizure termination and prevention of seizure clusters in adults admitted to the epilepsy monitoring unit (EMU) in whom seizures were captured on continuous video-electroencephalogram." | 3.91 | Comparison of intranasal midazolam versus intravenous lorazepam for seizure termination and prevention of seizure clusters in the adult epilepsy monitoring unit. ( Bautista, C; Cotugno, S; Deng, Y; Dhakar, MB; Farooque, P; Hirsch, LJ; Maciel, CB; McKimmy, D; Owusu, KA; Sukumar, N, 2019) |
| "We report two cases of unusual movement disorders associated with the use of gabapentin (GBP) in patients being treated for epilepsy who were otherwise neurologically intact." | 3.69 | Movement disorders associated with the use of gabapentin. ( Krahn, LE; Reeves, AL; Sharbrough, FW; So, EL, 1996) |
| "Acute seizure and status epilepticus constitute one of the major medical emergencies in children." | 2.48 | Management of acute seizure and status epilepticus in pediatric emergency. ( Sasidaran, K; Singhi, P; Singhi, S, 2012) |
| "Minimal requirements: seizure-prevention outcome given as fraction of cases; AED or control assigned by random or quasi-random mechanism." | 2.41 | Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. ( Temkin, NR, 2001) |
| "Sequelae and risk for recurrence of SE are primarily related to the underlying cause." | 2.39 | Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment. ( Mitchell, WG, 1996) |
| " However, their chronic use may be associated with serious sedative-hypnotic effects that interfere with cognitive function and behavior." | 2.37 | Use of barbiturates and benzodiazepines in treatment of epilepsy. ( Vining, EP, 1986) |
| "Epilepsy is very difficult to treat and often involves the combination of two or more AEDs." | 1.56 | Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database. ( Hayashi, T; Noguchi, Y; Tachi, T; Takaoka, M; Teramachi, H, 2020) |
| "We report a case of a patient with status migrainosus unresponsive to analgesic therapy in whom electroencephalographic recording revealed an epileptic origin." | 1.37 | Ictal epileptic headache mimicking status migrainosus: EEG and DWI-MRI findings. ( Belcastro, V; Calabresi, P; Pierguidi, L; Striano, P; Tambasco, N, 2011) |
| "Both pseudoseizures and hysterical stridor are associated commonly with sexual abuse, eating disorders, depression, substance abuse, anxiety disorders, and personality disorders." | 1.32 | Pseudoseizures and hysterical stridor. ( Kaufman, KR; Mohebati, A; Sotolongo, A, 2004) |
| "Seizures are a frequent problem confronting EMS personnel." | 1.30 | Prehospital management of the seizure patient. ( Nicholl, JS, 1999) |
| "The most common expected adverse effects during implant were fever < or = 102 degrees (41%), cerebrospinal fluid leakage (19%), headache (15%), and nausea (4%)." | 1.29 | The safety and efficacy of chronically implanted subdural electrodes: a prospective study. ( Delgado-Escueta, AV; DeSalles, A; Dwan, PS; Kaufman, MH; Rich, JR; Swartz, BE; Walsh, GO, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (20.00) | 18.7374 |
| 1990's | 9 (30.00) | 18.2507 |
| 2000's | 7 (23.33) | 29.6817 |
| 2010's | 4 (13.33) | 24.3611 |
| 2020's | 4 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Lelis, IR | 1 |
| Krauss, GL | 1 |
| Lawal, OD | 1 |
| Meador, KJ | 1 |
| Hume, AL | 1 |
| Wen, X | 1 |
| Szaflarski, JP | 1 |
| Sadek, A | 1 |
| Greve, B | 1 |
| Williams, P | 1 |
| Varner, JA | 1 |
| Moseley, BD | 1 |
| Noguchi, Y | 1 |
| Takaoka, M | 1 |
| Hayashi, T | 1 |
| Tachi, T | 1 |
| Teramachi, H | 1 |
| Owusu, KA | 1 |
| Dhakar, MB | 1 |
| Bautista, C | 1 |
| McKimmy, D | 1 |
| Cotugno, S | 1 |
| Sukumar, N | 1 |
| Deng, Y | 1 |
| Farooque, P | 1 |
| Hirsch, LJ | 1 |
| Maciel, CB | 1 |
| Khalafian, A | 1 |
| Dukes, C | 1 |
| Tucker, P | 1 |
| Belcastro, V | 1 |
| Striano, P | 1 |
| Pierguidi, L | 1 |
| Calabresi, P | 1 |
| Tambasco, N | 1 |
| Sasidaran, K | 1 |
| Singhi, S | 1 |
| Singhi, P | 1 |
| Kaufman, KR | 1 |
| Mohebati, A | 1 |
| Sotolongo, A | 1 |
| Monto, S | 1 |
| Vanhatalo, S | 1 |
| Holmes, MD | 1 |
| Palva, JM | 1 |
| von Wrede, R | 1 |
| Delima, SI | 1 |
| Walsh, LE | 1 |
| Golomb, MR | 1 |
| Scott, DF | 1 |
| Moffett, A | 1 |
| Jensen, FE | 1 |
| Blume, H | 1 |
| Alvarado, S | 1 |
| Firkusny, I | 1 |
| Geary, C | 1 |
| Appleton, R | 1 |
| Sweeney, A | 1 |
| Choonara, I | 1 |
| Robson, J | 1 |
| Molyneux, E | 1 |
| Mitchell, WG | 1 |
| Swartz, BE | 1 |
| Rich, JR | 1 |
| Dwan, PS | 1 |
| DeSalles, A | 1 |
| Kaufman, MH | 1 |
| Walsh, GO | 1 |
| Delgado-Escueta, AV | 1 |
| Vivancos Mora, J | 1 |
| Reeves, AL | 1 |
| So, EL | 1 |
| Sharbrough, FW | 1 |
| Krahn, LE | 1 |
| Masson, C | 1 |
| Nicholl, JS | 1 |
| Temkin, NR | 1 |
| Lee, SA | 1 |
| Lee, JK | 1 |
| Heo, K | 1 |
| Erickson, KR | 1 |
| Yager, JY | 1 |
| Seshia, SS | 1 |
| Vining, EP | 1 |
| Soni, SD | 1 |
| Smith, ED | 1 |
| Shah, A | 1 |
| Hall, J | 1 |
| Farrell, K | 1 |
| Figueroa, RG | 1 |
| Figueroa, EG | 1 |
| Sneed, GA | 1 |
| Kennedy, MJ | 1 |
6 reviews available for lorazepam and Epilepsy
| Article | Year |
|---|---|
Management of acute seizure and status epilepticus in pediatric emergency.
Topics: Anesthesia, Intravenous; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Combined Modalit | 2012 |
Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Benzodiazepines; Central Nervous System Disea | 1996 |
[Treatment of neurological complications: cerebral edema and epileptic seizures].
Topics: Adrenal Cortex Hormones; Anticonvulsants; Brain Edema; Brain Ischemia; Carbamazepine; Diuretics, Osm | 1995 |
Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials.
Topics: Anticonvulsants; Brain Diseases; Brain Injuries; Carbamazepine; Controlled Clinical Trials as Topic; | 2001 |
Amnestic disorders. Pathophysiology and patterns of memory dysfunction.
Topics: Adrenocorticotropic Hormone; Age Factors; Amnesia; Brain Injuries; Epilepsy; Humans; Lorazepam; Mult | 1990 |
Use of barbiturates and benzodiazepines in treatment of epilepsy.
Topics: Adult; Barbiturates; Benzodiazepines; Child; Clonazepam; Clorazepate Dipotassium; Diazepam; Epilepsy | 1986 |
4 trials available for lorazepam and Epilepsy
| Article | Year |
|---|---|
Randomized open-label trial of intravenous brivaracetam versus lorazepam for acute treatment of increased seizure activity.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Anticonvulsants; Dizziness; Double-Blind Metho | 2020 |
Epileptogenic neocortical networks are revealed by abnormal temporal dynamics in seizure-free subdural EEG.
Topics: Adult; Anticonvulsants; Beta Rhythm; Brain Mapping; Electrodes, Implanted; Epilepsy; Female; Humans; | 2007 |
Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus.
Topics: Administration, Rectal; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Injections, Intravenou | 1995 |
[Treatment for generalized seizures: the best of four methods].
Topics: Anticonvulsants; Diazepam; Epilepsy; Humans; Lorazepam; Phenobarbital; Phenytoin | 1999 |
20 other studies available for lorazepam and Epilepsy
| Article | Year |
|---|---|
Sublingual lorazepam as rescue therapy for seizure emergencies in adults.
Topics: Adult; Anticonvulsants; Diazepam; Emergencies; Epilepsy; Humans; Lorazepam; Retrospective Studies; S | 2023 |
Utilization of Antiseizure Medications in Women of Childbearing Age With Epilepsy and Nonepilepsy Indications: A Retrospective Cohort Study.
Topics: Anticonvulsants; Clonazepam; Diazepam; Epilepsy; Female; Gabapentin; Humans; Lamotrigine; Lorazepam; | 2023 |
Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database.
Topics: Anticonvulsants; Carbamazepine; Clobazam; Clonazepam; Databases, Factual; Drug Therapy, Combination; | 2020 |
Comparison of intranasal midazolam versus intravenous lorazepam for seizure termination and prevention of seizure clusters in the adult epilepsy monitoring unit.
Topics: Administration, Intranasal; Administration, Intravenous; Adult; Anticonvulsants; Epilepsy; Female; H | 2019 |
Consultation Dilemma Catatonia in a Patient with Prior TBI: MentaI or Medical Disorder?
Topics: Adult; Anticonvulsants; Behavior Observation Techniques; Brain Injuries; Catatonia; Depression; Diag | 2015 |
Guidelines for diagnosis and management of childhood epilepsy.
Topics: Algorithms; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Hu | 2009 |
Ictal epileptic headache mimicking status migrainosus: EEG and DWI-MRI findings.
Topics: Anticonvulsants; Diffusion Magnetic Resonance Imaging; Electroencephalography; Epilepsy; Female; Hea | 2011 |
Pseudoseizures and hysterical stridor.
Topics: Academic Medical Centers; Adult; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents, Second | 2004 |
[Epilepsy: which therapy in acute care?].
Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Clobazam; Clonazepam; Diazepam; Epilepsy; Humans; L | 2006 |
Simultaneous toxicities in a child on multiple anticonvulsants.
Topics: Anticonvulsants; Bone Marrow; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Child, P | 2008 |
Lorazepam: its effect on the EEG paroxysmal activity in patients with epilepsy.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Brain; Child; Electroencephalography; Epilepsies, Partial; E | 1981 |
NBQX blocks acute and late epileptogenic effects of perinatal hypoxia.
Topics: Age Factors; Animals; Dizocilpine Maleate; Epilepsy; Excitatory Amino Acid Antagonists; Flurothyl; H | 1995 |
The safety and efficacy of chronically implanted subdural electrodes: a prospective study.
Topics: Anticonvulsants; Brain; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epileps | 1996 |
Movement disorders associated with the use of gabapentin.
Topics: Acetates; Adult; Amines; Anticonvulsants; Benzodiazepines; Cyclohexanecarboxylic Acids; Dyskinesia, | 1996 |
Prehospital management of the seizure patient.
Topics: Adolescent; Adult; Airway Obstruction; Anticonvulsants; Child; Diazepam; Emergency Medical Technicia | 1999 |
Coma probably induced by lorazepam-valproate interaction.
Topics: Adult; Anticonvulsants; Coma; Drug Interactions; Epilepsy; Female; Humans; Lorazepam; Valproic Acid | 2002 |
Sublingual lorazepam in childhood serial seizures.
Topics: Administration, Sublingual; Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; L | 1988 |
Lorazepam withdrawal seizures: role of predisposition and multi-drug therapies.
Topics: Aged; Disease Susceptibility; Drug Therapy, Combination; Epilepsy; Female; Humans; Lorazepam; Male; | 1986 |
Benzodiazepines in the treatment of children with epilepsy.
Topics: Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Child; Child, Preschool; Clobazam; Clonazep | 1986 |
Effects of lorazepam on CNS structures: neurophysiological and behavioral correlations.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Behavior, Animal; Brain; Cats; Electric Stimulat | 1974 |