lorazepam has been researched along with Epilepsy, Tonic-Clonic in 16 studies
Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
Epilepsy, Tonic-Clonic: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To review the evidence comparing diazepam, lorazepam, phenobarbitone, phenytoin and paraldehyde in treating acute tonic-clonic convulsions and convulsive status epilepticus in children." | 4.81 | Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children. ( Appleton, R; Martland, T; Phillips, B, 2002) |
| " Three cases of convulsive status epilepticus (CSE) following abrupt discontinuation of long-term use of 25 mg of lorazepam in one patient and more than 20 mg of flunitrazepam in two patients are presented; they were non-epileptics and free of other high-risk factors for seizures." | 3.70 | Convulsive status epilepticus following abrupt high-dose benzodiazepine discontinuation. ( Angelopoulos, EK; Chioni, A; Daskalopoulou, EG; Gatzonis, SD; Mantouvalos, V; Siafakas, A; Zournas, C, 2000) |
| "Tardive seizures are typically associated with electroencephalographic evidence of ictal activity and motor manifestations of the tonic-clonic activity." | 1.40 | A case of atypical tardive seizure activity during an initial ECT titration series. ( Karim, Y; McCormick, LM; Thisayakorn, P; Yamada, T, 2014) |
| "After baseline recordings, seizures were induced with a pentylenetetrazol (PTZ) bolus and a 20 min infusion (5-6 mg/kg/min)." | 1.29 | Respiratory drive during status epilepticus and its treatment: comparison of diazepam and lorazepam. ( Fordyce, WE; Terndrup, TE, 1995) |
| "Lorazepam is a new member of a constantly growing benzodiazepine family." | 1.26 | Lorazepam-related withdrawal seizures. ( de la Fuente, JR; Martin, HR; Niven, RG; Rosenbaum, AH, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (25.00) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McTague, A | 1 |
| Martland, T | 2 |
| Appleton, R | 2 |
| Thisayakorn, P | 1 |
| Karim, Y | 1 |
| Yamada, T | 1 |
| McCormick, LM | 1 |
| Portilla-Botelho, M | 1 |
| Ortega-Carnicer, J | 1 |
| Gómez-Grande, ML | 1 |
| Martín-Rodríguez, C | 1 |
| Farooque, P | 1 |
| Khurana, DS | 1 |
| Melvin, JJ | 1 |
| Phillips, B | 1 |
| Wheless, JW | 1 |
| Einarson, TR | 1 |
| de la Fuente, JR | 1 |
| Rosenbaum, AH | 1 |
| Martin, HR | 1 |
| Niven, RG | 1 |
| Browne, TR | 1 |
| Morgan, DL | 1 |
| Durso, MH | 1 |
| Rich, BK | 1 |
| Kurt, TL | 1 |
| Terndrup, TE | 1 |
| Fordyce, WE | 1 |
| Thibodeau, LG | 1 |
| Ferrera, PC | 1 |
| Gatzonis, SD | 1 |
| Angelopoulos, EK | 1 |
| Daskalopoulou, EG | 1 |
| Mantouvalos, V | 1 |
| Chioni, A | 1 |
| Zournas, C | 1 |
| Siafakas, A | 1 |
| Butler, J | 1 |
| Lewis, M | 1 |
| Piepho, R | 1 |
| Whelton, A | 1 |
| Mayor, G | 1 |
| Neu, H | 1 |
| Laddu, A | 1 |
| Lacey, DJ | 1 |
| Singer, WD | 1 |
| Horwitz, SJ | 1 |
| Gilmore, H | 1 |
3 reviews available for lorazepam and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children.
Topics: Administration, Inhalation; Administration, Oral; Administration, Rectal; Anticonvulsants; Child; Di | 2018 |
Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children.
Topics: Administration, Rectal; Anticonvulsants; Child; Diazepam; Epilepsy, Tonic-Clonic; Humans; Injections | 2002 |
Acute management of seizures in the syndromes of idiopathic generalized epilepsies.
Topics: Acute Disease; Adolescent; Adult; Anticonvulsants; Clonazepam; Comorbidity; Drug Administration Sche | 2003 |
13 other studies available for lorazepam and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
A case of atypical tardive seizure activity during an initial ECT titration series.
Topics: Adult; Anticonvulsants; Brain; Depressive Disorder, Major; Electroconvulsive Therapy; Electroencepha | 2014 |
[Paroxetine-induced severe hyponatremic rhabdomyolisis].
Topics: Cations; Coma; Depressive Disorder; Diagnosis, Differential; Epilepsy, Tonic-Clonic; Female; Humans; | 2008 |
Persistent focal seizures after cat scratch encephalopathy.
Topics: Acyclovir; Anti-Bacterial Agents; Anticonvulsants; Antiviral Agents; Cat-Scratch Disease; Ceftriaxon | 2010 |
Lorazepam withdrawal seizures.
Topics: Anti-Anxiety Agents; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Humans; Lorazepam; Male; Mia | 1980 |
Lorazepam-related withdrawal seizures.
Topics: Adult; Anti-Anxiety Agents; Epilepsy, Tonic-Clonic; Female; Humans; Lorazepam; Pregnancy; Pregnancy | 1980 |
Therapy of status epilepticus.
Topics: Anticonvulsants; Diazepam; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Humans; Lorazepam; Paraldehy | 1982 |
Severe ethanol intoxication in an adolescent.
Topics: Adolescent; Alcoholic Intoxication; Combined Modality Therapy; Critical Care; Epilepsy, Tonic-Clonic | 1995 |
Respiratory drive during status epilepticus and its treatment: comparison of diazepam and lorazepam.
Topics: Animals; Diazepam; Disease Models, Animal; Epilepsy, Tonic-Clonic; Hydrogen-Ion Concentration; Loraz | 1995 |
Nonconvulsive status epilepticus.
Topics: Anticonvulsants; Dizziness; Electroencephalography; Emergency Service, Hospital; Epilepsy, Tonic-Clo | 1997 |
Convulsive status epilepticus following abrupt high-dose benzodiazepine discontinuation.
Topics: Adult; Anti-Anxiety Agents; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Female; Flunit | 2000 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Lorazepam or diazepam for generalised convulsions in adults.
Topics: Diazepam; Emergency Medical Services; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Evidence-Based | 2001 |
Grand mal status epilepticus.
Topics: Alcoholism; Anticonvulsants; Diazepam; Epilepsy, Tonic-Clonic; Ethanol; Humans; Lorazepam; Male; Mid | 1992 |
Lorazepam therapy of status epilepticus in children and adolescents.
Topics: Adolescent; Child; Child, Preschool; Drug Evaluation; Epilepsies, Partial; Epilepsy, Absence; Epilep | 1986 |