lorazepam has been researched along with Down Syndrome in 2 studies
Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with lorazepam led to improvement in symptoms in all, eventually reversing the catatonia in some children to previous baseline function." | 1.56 | Catatonia as a feature of down syndrome: An under-recognised entity? ( Allen, NM; Cahalane, D; Flanagan, O; Lyons, A, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lyons, A | 1 |
| Allen, NM | 1 |
| Flanagan, O | 1 |
| Cahalane, D | 1 |
| Cohen, WI | 1 |
| Liu, YH | 1 |
| Stein, MT | 1 |
2 other studies available for lorazepam and Down Syndrome
| Article | Year |
|---|---|
Catatonia as a feature of down syndrome: An under-recognised entity?
Topics: Adolescent; Anticonvulsants; Catatonia; Child; Down Syndrome; Female; Humans; Lorazepam; Male; Retro | 2020 |
A 7-year-old child with Down syndrome and disruptive behaviors.
Topics: Anti-Anxiety Agents; Attention Deficit and Disruptive Behavior Disorders; Child; Comorbidity; Diagno | 2007 |