lorazepam has been researched along with Disease Models, Animal in 19 studies
Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " As a step toward eventual coupling of rTMS with antiepileptic pharmacotherapy, we also tested whether high-frequency rTMS in combination with a low (ineffective but less likely to cause a side effect) lorazepam dose is as effective as a full lorazepam dose in suppressing seizures in a rat SE model." | 7.83 | Bursts of high-frequency repetitive transcranial magnetic stimulation (rTMS), together with lorazepam, suppress seizures in a rat kainate status epilepticus model. ( Dhamne, SC; Gersner, R; Pascual-Leone, A; Rotenberg, A; Zangen, A, 2016) |
| "We studied the efficacy, pharmacokinetics, and brain entry of lorazepam in the treatment of status epilepticus (SE) using a rat model of secondarily generalized convulsive SE." | 7.68 | Lorazepam treatment of experimental status epilepticus in the rat: relevance to clinical practice. ( Treiman, DM; Walton, NY, 1990) |
| "Status epilepticus was induced by intra-amygdala microinjection of kainic acid in 8week old C57Bl/6 mice." | 5.42 | Comparison of short-term effects of midazolam and lorazepam in the intra-amygdala kainic acid model of status epilepticus in mice. ( Diviney, M; Henshall, DC; Reynolds, JP, 2015) |
| " As a step toward eventual coupling of rTMS with antiepileptic pharmacotherapy, we also tested whether high-frequency rTMS in combination with a low (ineffective but less likely to cause a side effect) lorazepam dose is as effective as a full lorazepam dose in suppressing seizures in a rat SE model." | 3.83 | Bursts of high-frequency repetitive transcranial magnetic stimulation (rTMS), together with lorazepam, suppress seizures in a rat kainate status epilepticus model. ( Dhamne, SC; Gersner, R; Pascual-Leone, A; Rotenberg, A; Zangen, A, 2016) |
| "We studied the efficacy, pharmacokinetics, and brain entry of lorazepam in the treatment of status epilepticus (SE) using a rat model of secondarily generalized convulsive SE." | 3.68 | Lorazepam treatment of experimental status epilepticus in the rat: relevance to clinical practice. ( Treiman, DM; Walton, NY, 1990) |
| "Kainic acid (KA) is a potent glutamate analog that is used to induce neurodegeneration and model temporal lobe epilepsy (TLE) in rodents." | 1.46 | A novel animal model of acquired human temporal lobe epilepsy based on the simultaneous administration of kainic acid and lorazepam. ( Bauer, S; Costard, L; Kienzler-Norwood, F; Müller, P; Neubert, V; Norwood, BA; Rosenow, F; Sadangi, C, 2017) |
| "We utilized a middle cerebral artery occlusion model and examined seizure activity and brain injury using combined behavioral and electroencephalographic monitoring and histological assessments." | 1.42 | Modeling early-onset post-ischemic seizures in aging mice. ( Aljarallah, S; Eubanks, JH; Gao, X; Huang, Y; McDonald, R; Patel, N; Peng, J; Wang, J; Wu, C; Zhang, L, 2015) |
| "Status epilepticus was induced by intra-amygdala microinjection of kainic acid in 8week old C57Bl/6 mice." | 1.42 | Comparison of short-term effects of midazolam and lorazepam in the intra-amygdala kainic acid model of status epilepticus in mice. ( Diviney, M; Henshall, DC; Reynolds, JP, 2015) |
| "With either etiology, seizures are a poor prognostic factor." | 1.42 | Early-Onset Convulsive Seizures Induced by Brain Hypoxia-Ischemia in Aging Mice: Effects of Anticonvulsive Treatments. ( Aljarallah, S; Eubanks, JH; Gao, X; Huang, Y; McDonald, R; Patel, N; Peng, J; Wang, J; Wu, C; Zhang, L, 2015) |
| "After baseline recordings, seizures were induced with a pentylenetetrazol (PTZ) bolus and a 20 min infusion (5-6 mg/kg/min)." | 1.29 | Respiratory drive during status epilepticus and its treatment: comparison of diazepam and lorazepam. ( Fordyce, WE; Terndrup, TE, 1995) |
| "For antipyrine, clearance was decreased by 30% after shock and resuscitation (p = ." | 1.28 | Effect of experimental hemorrhagic shock on hepatic drug elimination. ( DiPiro, JT; Gaines, MG; Hooker, KD; Sherman, JC; Wynn, JJ, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 7 (36.84) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 8 (42.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ross, TM | 1 |
| Battista, K | 1 |
| Bignan, GC | 1 |
| Brenneman, DE | 1 |
| Connolly, PJ | 1 |
| Liu, J | 1 |
| Middleton, SA | 1 |
| Orsini, M | 1 |
| Reitz, AB | 1 |
| Rosenthal, DI | 1 |
| Scott, MK | 1 |
| Vaidya, AH | 1 |
| Cheng, JP | 1 |
| Leary, JB | 1 |
| O'Neil, DA | 1 |
| Meyer, EA | 1 |
| Free, KE | 1 |
| Bondi, CO | 1 |
| Kline, AE | 1 |
| Hadar, R | 1 |
| Edemann-Callesen, H | 1 |
| Hlusicka, EB | 1 |
| Wieske, F | 1 |
| Vogel, M | 1 |
| Günther, L | 1 |
| Vollmayr, B | 1 |
| Hellweg, R | 1 |
| Heinz, A | 1 |
| Garthe, A | 1 |
| Winter, C | 1 |
| Wu, C | 2 |
| Wang, J | 2 |
| Peng, J | 2 |
| Patel, N | 2 |
| Huang, Y | 2 |
| Gao, X | 2 |
| Aljarallah, S | 2 |
| Eubanks, JH | 2 |
| McDonald, R | 2 |
| Zhang, L | 2 |
| Diviney, M | 1 |
| Reynolds, JP | 1 |
| Henshall, DC | 1 |
| Gersner, R | 1 |
| Dhamne, SC | 1 |
| Zangen, A | 1 |
| Pascual-Leone, A | 1 |
| Rotenberg, A | 1 |
| Kienzler-Norwood, F | 1 |
| Costard, L | 1 |
| Sadangi, C | 1 |
| Müller, P | 1 |
| Neubert, V | 1 |
| Bauer, S | 1 |
| Rosenow, F | 1 |
| Norwood, BA | 1 |
| Porecha, S | 1 |
| shah, T | 1 |
| Jogani, V | 1 |
| Naik, S | 1 |
| Misra, A | 1 |
| Lang, AP | 1 |
| de Angelis, L | 1 |
| Deshpande, LS | 1 |
| Blair, RE | 1 |
| Nagarkatti, N | 1 |
| Sombati, S | 1 |
| Martin, BR | 1 |
| DeLorenzo, RJ | 1 |
| Terndrup, TE | 1 |
| Fordyce, WE | 1 |
| Jiang, Q | 1 |
| Walton, NY | 2 |
| Gunawan, S | 1 |
| Treiman, DM | 2 |
| Jensen, FE | 1 |
| Wang, C | 1 |
| Watson, GS | 1 |
| Roach, JT | 1 |
| Sufka, KJ | 1 |
| DiPiro, JT | 1 |
| Hooker, KD | 1 |
| Sherman, JC | 1 |
| Gaines, MG | 1 |
| Wynn, JJ | 1 |
| Piot, O | 1 |
| Betschart, J | 1 |
| Stutzmann, JM | 1 |
| Blanchard, JC | 1 |
| Syverud, SA | 1 |
| Dronen, SC | 1 |
| Chudnofsky, CR | 1 |
| van Ligten, PF | 1 |
1 review available for lorazepam and Disease Models, Animal
| Article | Year |
|---|---|
Hypoxia-induced hyperexcitability in vivo and in vitro in the immature hippocampus.
Topics: Age Factors; Animals; Disease Models, Animal; Dizocilpine Maleate; Electroencephalography; Electroph | 1996 |
18 other studies available for lorazepam and Disease Models, Animal
| Article | Year |
|---|---|
A selective small molecule NOP (ORL-1 receptor) partial agonist for the treatment of anxiety.
Topics: Animals; Anxiety; Disease Models, Animal; Motor Activity; Nociceptin; Nociceptin Receptor; Opioid Pe | 2015 |
Spontaneous recovery of traumatic brain injury-induced functional deficits is not hindered by daily administration of lorazepam.
Topics: Animals; Antipsychotic Agents; Brain Injuries, Traumatic; Cognition; Conditioning, Psychological; Di | 2018 |
Recurrent stress across life may improve cognitive performance in individual rats, suggesting the induction of resilience.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Cognition; Depression; Disease Models, Animal; Loraz | 2019 |
Modeling early-onset post-ischemic seizures in aging mice.
Topics: Aging; Analysis of Variance; Animals; Anticonvulsants; Brain; Chi-Square Distribution; Disease Model | 2015 |
Comparison of short-term effects of midazolam and lorazepam in the intra-amygdala kainic acid model of status epilepticus in mice.
Topics: Amygdala; Animals; Anticonvulsants; Benzodiazepines; Disease Models, Animal; Hippocampus; Kainic Aci | 2015 |
Early-Onset Convulsive Seizures Induced by Brain Hypoxia-Ischemia in Aging Mice: Effects of Anticonvulsive Treatments.
Topics: Age of Onset; Aging; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Hippocampus; | 2015 |
Bursts of high-frequency repetitive transcranial magnetic stimulation (rTMS), together with lorazepam, suppress seizures in a rat kainate status epilepticus model.
Topics: Animals; Anticonvulsants; Combined Modality Therapy; Disease Models, Animal; Kainic Acid; Lorazepam; | 2016 |
A novel animal model of acquired human temporal lobe epilepsy based on the simultaneous administration of kainic acid and lorazepam.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalo | 2017 |
Microemulsion based intranasal delivery system for treatment of insomnia.
Topics: Administration, Intranasal; Alprazolam; Animals; Diazepam; Disease Models, Animal; Drug Compounding; | 2009 |
Experimental anxiety and antiepileptics: the effects of valproate and vigabatrin in the mirrored chamber test.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Conflict, Psychological; Disease Models, Ani | 2003 |
Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus.
Topics: Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Benzodiazepines; Benzoxazines; Calciu | 2007 |
Respiratory drive during status epilepticus and its treatment: comparison of diazepam and lorazepam.
Topics: Animals; Diazepam; Disease Models, Animal; Epilepsy, Tonic-Clonic; Hydrogen-Ion Concentration; Loraz | 1995 |
High-performance liquid chromatographic determination of midazolam in rat brain.
Topics: Animals; Anti-Anxiety Agents; Brain Chemistry; Chromatography, High Pressure Liquid; Diazepam; Disea | 1996 |
Benzodiazepine receptor function in the chick social separation-stress procedure.
Topics: Alprazolam; Analgesia; Animals; Anti-Anxiety Agents; Chickens; Chlordiazepoxide; Disease Models, Ani | 1999 |
Effect of experimental hemorrhagic shock on hepatic drug elimination.
Topics: Animals; Antipyrine; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; Half-Life | 1992 |
Cyclopyrrolones, unlike some benzodiazepines, do not induce physical dependence in mice.
Topics: Animals; Azabicyclo Compounds; Carbolines; Convulsants; Diazepam; Disease Models, Animal; Flunitraze | 1990 |
Lorazepam treatment of experimental status epilepticus in the rat: relevance to clinical practice.
Topics: Animals; Brain; Disease Models, Animal; Lorazepam; Rats; Rats, Inbred Strains; Status Epilepticus | 1990 |
A continuous hemorrhage model of fatal hemorrhagic shock in swine.
Topics: Animals; Blood Volume; Disease Models, Animal; Hemodynamics; Hemorrhage; Lorazepam; Respiration; Sho | 1989 |