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lorazepam and Depression

lorazepam has been researched along with Depression in 24 studies

Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
" Citalopram, a newer generation SSRI, is commonly prescribed, but despite its low toxicity profile has a potential to cause seizures and dysarrythmias in overdose."7.76Metabolic acidosis and generalized seizures secondary to citalopram overdose: a case report. ( Al Anazi, T; Al Hayyan, H; Al Hussein, M; Al Modaimegh, H; Al Qahtani, M; Bin Salih, S, 2010)
"Aripiprazole was associated with beneficial effects on mood in patients with bipolar depression, and appears well tolerated with very small changes in mean body weight."5.13Beneficial acute antidepressant effects of aripiprazole as an adjunctive treatment or monotherapy in bipolar patients unresponsive to mood stabilizers: results from a 16-week open-label trial. ( Bria, P; Janiri, L; Mazza, M; Pecora, RD; Squillacioti, MR, 2008)
"In 60 patients undergoing a curettage in thiopentone induced inhalation anaesthesia with enflurane and N2O/O2 = 2:1, the effects of oral premedication (2 h before anaesthesia) with 30 mg morphine (MST 30) (n = 21), 1 mg lormetazepam (Noctamid) (n = 19) and placebo (n = 21) on psychological (anxiety, depression and asthenia), physiological (blood pressure, heart and respiratory rate) and pain parameters (visual analogue scale, analgesic consumption) were investigated."5.06[Effect and side effects of oral morphine, lormetazepam and placebos as premedication]. ( Hartung, M; Hettenbach, A; Krug, C; Tolksdorf, W, 1987)
"From a retrospective cohort of clinically depressed patients that were treated with rTMS, we compared 176 patients not taking any BZD with 73 patients taking lorazepam with respect to changes in the Hamilton Depression Rating Scale (HRDS)."4.02Concomitant lorazepam use and antidepressive efficacy of repetitive transcranial magnetic stimulation in a naturalistic setting. ( Abdelnaim, M; Deppe, M; Hebel, T; Kreuzer, PM; Langguth, B; Poeppl, TB; Schecklmann, M, 2021)
"The World Health Organization recommends that anxiety, depression, agitation and delirium at end of life should be treated with drugs such as lorazepam, diazepam, midazolam and haloperidol."3.83Look again at psychedelic drugs. ( Cameron, R, 2016)
" Citalopram, a newer generation SSRI, is commonly prescribed, but despite its low toxicity profile has a potential to cause seizures and dysarrythmias in overdose."3.76Metabolic acidosis and generalized seizures secondary to citalopram overdose: a case report. ( Al Anazi, T; Al Hayyan, H; Al Hussein, M; Al Modaimegh, H; Al Qahtani, M; Bin Salih, S, 2010)
"Aripiprazole was superior to placebo in delaying time to manic relapse (p = ."2.73Aripiprazole monotherapy for maintenance therapy in bipolar I disorder: a 100-week, double-blind study versus placebo. ( Calabrese, JR; Carlson, BX; Carson, WH; Eudicone, JM; Keck, PE; Marcus, RN; McIntyre, RS; McQuade, RD; Sanchez, R, 2007)
"He was diagnosed with catatonia and treated successfully with lorazepam."1.51Temporal glioblastoma presenting as catatonia. ( Franssen, A; Sienaert, P, 2019)
"The seizure was successfully treated with benzodiazepines."1.32Seizure secondary to citalopram overdose. ( Cuenca, PJ; Hoefle, JD; Holt, KR, 2004)
"lorazepam t."1.25Treatment of 'brain fag' syndrome. ( Anumonye, A, 1975)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19907 (29.17)18.7374
1990's3 (12.50)18.2507
2000's3 (12.50)29.6817
2010's8 (33.33)24.3611
2020's3 (12.50)2.80

Authors

AuthorsStudies
Laurin, A1
Capelle, N1
Bukowski, N1
Le Page, A1
Gendre, I1
Sauvaget, A1
Bulteau, S1
Pérez, T1
Pardo, MC1
Cabellos, Y1
Peressini, M1
Ureña-Vacas, I1
Serrano, DR1
González-Burgos, E1
Deppe, M1
Abdelnaim, M1
Hebel, T1
Kreuzer, PM1
Poeppl, TB1
Langguth, B1
Schecklmann, M1
Franssen, A1
Sienaert, P1
Hadar, R1
Edemann-Callesen, H1
Hlusicka, EB1
Wieske, F1
Vogel, M1
Günther, L1
Vollmayr, B1
Hellweg, R1
Heinz, A1
Garthe, A1
Winter, C1
Nishiyama, A1
Matsumoto, H1
Huang, TH1
Hong, CJ1
Avalos-Franco, N1
Castellar-Cerpa, J1
Santos-Bueso, E1
Sáenz-Francés, F1
García Sánchez, J1
Khalafian, A1
Dukes, C1
Tucker, P1
Cameron, R1
Mazza, M1
Squillacioti, MR1
Pecora, RD1
Janiri, L1
Bria, P1
Bin Salih, S1
Al Qahtani, M1
Al Anazi, T1
Al Hussein, M1
Al Hayyan, H1
Al Modaimegh, H1
Cuenca, PJ1
Holt, KR1
Hoefle, JD1
Keck, PE1
Calabrese, JR1
McIntyre, RS1
McQuade, RD1
Carson, WH1
Eudicone, JM1
Carlson, BX1
Marcus, RN1
Sanchez, R1
Fitzal, S1
Groll-Knapp, E1
Länger, W1
Riegler, R1
Laakman, G1
Faltermaier-Temizel, M1
Bossert-Zaudig, S1
Baghai, T1
Lorkowski, G1
Lynch, G1
Green, JF1
King, DJ1
McCurdy, L1
Schatzberg, AF1
Anumonye, A1
Philipp, M1
Göttinger, E1
Petracca, A1
Michelini, S1
Perugi, G1
Cassano, GB1
Tolksdorf, W1
Krug, C1
Hartung, M1
Hettenbach, A1
Manfè, AZ1
Bonea, M1
Da Rold, A1
Maffei Faccioli, A1
Terranova, O1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00036348]Phase 30 participants Interventional2000-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

8 trials available for lorazepam and Depression

ArticleYear
Beneficial acute antidepressant effects of aripiprazole as an adjunctive treatment or monotherapy in bipolar patients unresponsive to mood stabilizers: results from a 16-week open-label trial.
    Expert opinion on pharmacotherapy, 2008, Volume: 9, Issue:18

    Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Ag

2008
Aripiprazole monotherapy for maintenance therapy in bipolar I disorder: a 100-week, double-blind study versus placebo.
    The Journal of clinical psychiatry, 2007, Volume: 68, Issue:10

    Topics: Adult; Antipsychotic Agents; Aripiprazole; Bipolar Disorder; Depression; Diagnostic and Statistical

2007
[Premedication with flunitrazepam, lormetazepam or pethidine-promethazine. Psychometric study of subjective conditions].
    Der Anaesthesist, 1983, Volume: 32, Issue:6

    Topics: Adult; Amnesia; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Depression; Emotions; Flunitrazepam;

1983
Treatment of depressive outpatients with lorazepam, alprazolam, amytriptyline and placebo.
    Psychopharmacology, 1995, Volume: 120, Issue:1

    Topics: Adult; Aged; Alprazolam; Amitriptyline; Antidepressive Agents; Depression; Female; Humans; Lorazepam

1995
Antipsychotic drug-induced dysphoria.
    The British journal of psychiatry : the journal of mental science, 1996, Volume: 169, Issue:4

    Topics: Adolescent; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Depression; Double-Blind Method; H

1996
Studies with oral lorazepam in anxiety neurosis associated with depressive symptomatology.
    The Journal of clinical psychiatry, 1978, Volume: 39, Issue:10 Pt 2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Anxiety Agents; Anxiety Disorders; Depression; D

1978
[Benzodiazepine withdrawal syndrome. Problems of differential diagnosis against depression, panic attacks and generalized anxiety].
    La Clinica terapeutica, 1991, May-15, Volume: 137, Issue:3

    Topics: Anxiety; Benzodiazepines; Depression; Diagnosis, Differential; Double-Blind Method; Humans; Lorazepa

1991
[Effect and side effects of oral morphine, lormetazepam and placebos as premedication].
    Anasthesie, Intensivtherapie, Notfallmedizin, 1987, Volume: 22, Issue:3

    Topics: Administration, Oral; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Clinical Trials as Topic; Depre

1987

Other Studies

16 other studies available for lorazepam and Depression

ArticleYear
[Ketamine and lorazepam combination as an alternative to electroconvulsive therapy for catatonia in late-life depression: A case report].
    L'Encephale, 2023, Volume: 49, Issue:5

    Topics: Catatonia; Depression; Electroconvulsive Therapy; Humans; Ketamine; Lorazepam

2023
Mental health and drug use in college students: Should we take action?
    Journal of affective disorders, 2023, 10-01, Volume: 338

    Topics: Anxiety; COVID-19; Depression; Humans; Lorazepam; Mental Health; Students; Substance-Related Disorde

2023
Concomitant lorazepam use and antidepressive efficacy of repetitive transcranial magnetic stimulation in a naturalistic setting.
    European archives of psychiatry and clinical neuroscience, 2021, Volume: 271, Issue:1

    Topics: Depression; Depressive Disorder, Major; Female; Humans; Lorazepam; Male; Middle Aged; Retrospective

2021
Temporal glioblastoma presenting as catatonia.
    BMJ case reports, 2019, Mar-04, Volume: 12, Issue:3

    Topics: Anti-Anxiety Agents; Catatonia; Chemotherapy, Adjuvant; Depression; Glioblastoma; Humans; Lorazepam;

2019
Recurrent stress across life may improve cognitive performance in individual rats, suggesting the induction of resilience.
    Translational psychiatry, 2019, 08-05, Volume: 9, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Cognition; Depression; Disease Models, Animal; Loraz

2019
Quetiapine reduces irritability and risk of suicide in patients with agitated depression.
    The Tokai journal of experimental and clinical medicine, 2013, Jul-20, Volume: 38, Issue:2

    Topics: Antipsychotic Agents; Anxiety; Depression; Dibenzothiazepines; Drug Therapy, Combination; Female; Hu

2013
Meningioma presenting with treatment-refractory depression.
    The Journal of neuropsychiatry and clinical neurosciences, 2014,Winter, Volume: 26, Issue:1

    Topics: Antiemetics; Depression; Female; Humans; Lorazepam; Meningeal Neoplasms; Meningioma; Middle Aged

2014
Angle closure secondary to the use of lorazepam in patient with myopia magna.
    Archivos de la Sociedad Espanola de Oftalmologia, 2015, Volume: 90, Issue:12

    Topics: Acetazolamide; Cholinergic Antagonists; Combined Modality Therapy; Depression; Dexamethasone; Diseas

2015
Consultation Dilemma Catatonia in a Patient with Prior TBI: MentaI or Medical Disorder?
    The Journal of the Oklahoma State Medical Association, 2015, Volume: 108, Issue:8

    Topics: Adult; Anticonvulsants; Behavior Observation Techniques; Brain Injuries; Catatonia; Depression; Diag

2015
Look again at psychedelic drugs.
    Nursing standard (Royal College of Nursing (Great Britain) : 1987), 2016, Jun-29, Volume: 30, Issue:44

    Topics: Anxiety; Delirium; Depression; Diazepam; Hallucinogens; Haloperidol; Humans; Lorazepam; Midazolam; P

2016
Metabolic acidosis and generalized seizures secondary to citalopram overdose: a case report.
    Journal of clinical pharmacy and therapeutics, 2010, Volume: 35, Issue:4

    Topics: Acidosis; Anticonvulsants; Citalopram; Depression; Drug Overdose; Female; Humans; Lorazepam; Seizure

2010
Seizure secondary to citalopram overdose.
    The Journal of emergency medicine, 2004, Volume: 26, Issue:2

    Topics: Adenosine; Adult; Anti-Arrhythmia Agents; Anticonvulsants; Antidepressive Agents, Second-Generation;

2004
Treatment of 'brain fag' syndrome.
    Current medical research and opinion, 1975, Volume: 3, Issue:6

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anxiety Disorders; Depression; Humans; Lorazepam; Male; Nige

1975
[Course of depression after sleep deprivation (author's transl)].
    Der Nervenarzt, 1978, Volume: 49, Issue:2

    Topics: Depression; Female; Humans; Lithium; Lorazepam; Male; Middle Aged; Sleep Deprivation; Time Factors

1978
[The incidence of masked depression in gynecological practice].
    Wiener medizinische Wochenschrift (1946), 1978, Jun-20, Volume: 128, Issue:12

    Topics: Anthracenes; Depression; Drug Combinations; Female; Flupenthixol; Humans; Lorazepam; Medical History

1978
[A case of dynamic ileus caused by tricyclic antidepressive agents].
    Minerva chirurgica, 1988, Dec-31, Volume: 43, Issue:23-24

    Topics: Antidepressive Agents, Tricyclic; Depression; Desipramine; Drug Therapy, Combination; Female; Humans

1988