lorazepam has been researched along with Chemical Dependence in 87 studies
Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A young male with schizophrenia, dependence syndrome (multiple drug use) and a severe depressive episode develops a serotonin syndrome with Sertraline and Ziprasidone." | 7.85 | [Psychosis, Intoxication or Serotonin Syndrome? - A 20-Year Old Male with Ziprasidone und Sertraline]. ( Grabe, HJ; Janowitz, D; Schomerus, G; Speerforck, S, 2017) |
| "A 53-year-old man with a 3-month addiction to approximately 5 mg/day of triazolam experienced psychosis and delirium following relatively abrupt withdrawal from the drug." | 7.67 | A case of psychosis and delirium following withdrawal from triazolam. ( Capwell, R; Heritch, AJ; Roy-Byrne, PP, 1987) |
| "A young male with schizophrenia, dependence syndrome (multiple drug use) and a severe depressive episode develops a serotonin syndrome with Sertraline and Ziprasidone." | 3.85 | [Psychosis, Intoxication or Serotonin Syndrome? - A 20-Year Old Male with Ziprasidone und Sertraline]. ( Grabe, HJ; Janowitz, D; Schomerus, G; Speerforck, S, 2017) |
| "Diazepam and lorazepam were more euphoriant than placebo; alprazolam's euphoriant effect did not differ from these treatments." | 3.76 | Comparative study of the abuse liability of alprazolam, lorazepam, diazepam, methaqualone, and placebo. ( Beake, B; Bird, M; Cole, JO; Dessain, E; Friedman, L; McEachern, J; Orzack, MH, 1988) |
| "Pretreatment with R121919 attenuated the subsequent HPA axis activation, behavioral measures of anxiety, and expression of the CRF gene in the paraventricular nucleus of the hypothalamus, as measured by CRF heteronuclear RNA, which occurs after flumazenil-precipitation of withdrawal from the BZ, lorazepam." | 3.74 | The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal. ( Gutman, DA; Nemeroff, CB; Owens, MJ; Skelton, KH; Thrivikraman, KV, 2007) |
| "In this study, we present five cases of seizures following withdrawal of flunitrazepam, lorazepam, or triazolam, representing 3% of a sample consisting of 153 patients dependent on benzodiazepines." | 3.69 | Benzodiazepine withdrawal syndrome seizures. ( de Iceta, M; Martínez-Cano, H; Martínez-Gras, I; Pomalima, R; Vela-Bueno, A, 1995) |
| "A 53-year-old man with a 3-month addiction to approximately 5 mg/day of triazolam experienced psychosis and delirium following relatively abrupt withdrawal from the drug." | 3.67 | A case of psychosis and delirium following withdrawal from triazolam. ( Capwell, R; Heritch, AJ; Roy-Byrne, PP, 1987) |
| "Tramadol is a mu opioid agonist that also inhibits the reuptake of norepinephrine and serotonin." | 2.71 | Profiling the subjective, psychomotor, and physiological effects of tramadol in recreational drug users. ( Zacny, JP, 2005) |
| "Lorazepam was liked better than were other drugs only at 1 hour and only compared with buspirone 20 and placebo." | 2.67 | Comparative drug effects and abuse liability of lorazepam, buspirone, and secobarbital in nondependent subjects. ( Kaplan, HL; Romach, MK; Schneiderman, JF; Sellers, EM; Somer, GR, 1992) |
| "There were few differences in withdrawal symptoms between the three groups but, despite the higher dropout rate, these symptoms were somewhat less marked in the lorazepam group." | 2.67 | A double-blind comparison of the effects of gradual withdrawal of lorazepam, diazepam and bromazepam in benzodiazepine dependence. ( Murphy, SM; Tyrer, P, 1991) |
| " Psychomotor and cognitive performance measures and subject- and observer-rated behavioral responses were measured daily before dosing and for 5." | 2.66 | Evaluation of the abuse potential of methocarbamol. ( Griffiths, RR; Guarino, JJ; Kirk, WT; Preston, KL, 1989) |
| " Generally, both LZ and MEP produced comparable dose-related effects; LZ had a more rapid onset of action and on several measures showed a more shallow dose-response curve than MEP." | 2.66 | Lorazepam and meprobamate dose effects in humans: behavioral effects and abuse liability. ( Griffiths, RR; Roache, JD, 1987) |
| "However, withdrawal symptoms may occur in patients receiving recommended doses and/or short-term therapy." | 2.36 | Benzodiazepine withdrawal syndrome: a literature review and evaluation. ( MacKinnon, GL; Parker, WA, 1982) |
| " A 30-year-old female elite athlete developed lormetazepam addiction after increasing her daily benzodiazepine dosage in an attempt to achieve better sleep and enhanced performances during training." | 1.51 | Benzodiazepine abuse among athletes: Pain relief or just a weapon against insomnia? A clinical case study. ( Lugoboni, F; Zamboni, L; Zandonai, T, 2019) |
| " Socio-demographic (more women; higher age and education) and clinical features (higher daily diazepam dosage equivalent, BZD abuse duration, age of first BZD intake; BZD prescribed more frequently for sleep disorders; less frequent history of other SUDs, previous/active alcohol, previous opioids abuse; more frequent overall major psychiatric diseases and major depression; less-frequent bipolar disorders and other psychoses, personality disorders, and more than one psychiatric disease) of LMZ vs." | 1.51 | High-dose lormetazepam dependence: strange case of Dr. Jekyll and Mr. Hyde. ( Casari, R; Faccini, M; Lugoboni, F; Morbioli, L; Tamburin, S, 2019) |
| "Treatment with carisoprodol and phenobarbital provided additional benefit and can be considered in cases of severe carisoprodol withdrawal." | 1.46 | Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose. ( Benowitz, NL; Horng, H; Smollin, CG; Vo, KT, 2017) |
| "A 24-year old woman with multisubstance use since the age of 13, including opioids and cocaine, and long-standing HIV/HCV seropositivity status, presented with psychosis, agitation, and insomnia at the emergency department of a university hospital." | 1.43 | Use of benzylglycinamide by a HIV-seropositive polysubstance user: The changing pattern of novel psychoactive substance use among youths. ( Calabrò, G; Caloro, M; Corkery, JM; Cuomo, I; De Filippis, S; de Pisa, E; Di Tommaso, A; Girardi, P; Kotzalidis, GD; Lionetto, L; Locatelli, CA; Lonati, D; Ranieri, V; Schifano, F; Vento, AE, 2016) |
| "Lorazepam was more frequently used by males, consumed for a long period, in pills, and prescribed for anxiety." | 1.43 | Socio-demographic and clinical characteristics of benzodiazepine long-term users: Results from a tertiary care center. ( Casari, R; Cosci, F; Faccini, M; Lugoboni, F; Mansueto, G, 2016) |
| "Propofol is an addictive drug, and the problem of its abuse and dependence has occurred." | 1.42 | Increased use in propofol and reported patterns of adverse events among anesthetics in Korea. ( Kim, MH; Park, BJ; Park, HJ; Shin, JY, 2015) |
| "However in those cases withdrawal symptoms were distinct and the medical intervention was needed." | 1.38 | [Description of a patient with schizophrenia and coexisting megadose lorazepam dependence with slightly expressed withdrawl symptoms during drug reduction. A case report]. ( Badura-Brzoza, K; Pasierb, N; Schylla, A; Scisło, P, 2012) |
| "Remifentanil delivery was maintained during testing in one punishment group but not the other." | 1.33 | Lorazepam reinstates punishment-suppressed remifentanil self-administration in rats. ( Panlilio, LV; Schindler, CW; Thorndike, EB, 2005) |
| "Isradipine inhibited lorazepam withdrawal symptoms, the effect being accompanied in the 24-h withdrawal group by significant decreases in the noradrenaline and dopamine content of the thalamus and hypothalamus and in the noradrenaline content of the mid-brain." | 1.30 | Influence of certain calcium-channel blockers on some aspects of lorazepam-dependence in mice. ( Attia, AS; Khayyal, MT; Saad, ES; Saad, SF, 1997) |
| " A dose-response relationship with regard to lorazepam (0." | 1.30 | Development of physical dependence to lorazepam in rats: the effects of repeated short treatments, dose and age. ( Carlsson, S; Korkmaz, S; Wahlström, G, 1998) |
| " The switch to oral agents must take into consideration the differences in potency, half-life, and oral bioavailability between the agents." | 1.29 | Outpatient therapy of iatrogenic drug dependency following prolonged sedation in the pediatric intensive care unit. ( Deshpande, JK; Gregory, DF; Tobias, JD, 1994) |
| " Flupirtine yielded a dose-response curve with an ED50 of 3." | 1.28 | Investigations with the novel non-opioid analgesic flupirtine in regard to possible benzodiazepine-like abuse inducing potential. ( Borbe, HO; Nickel, B; Szelenyi, I, 1990) |
| "Dogs, surgically implanted with a gastric fistula, were chronically dosed with diazepam or lorazepam." | 1.27 | Physical dependence on diazepam and lorazepam in the dog. ( Cherian, S; Martin, WR; McNicholas, LF, 1983) |
| "Lorazepam-treated baboons displayed precipitated withdrawal signs following the administration of Ro 15-1788 (5 mg/kg), and displayed mild to moderate spontaneous withdrawal signs following termination of drug treatment." | 1.27 | Precipitated and spontaneous withdrawal in baboons after chronic dosing with lorazepam and CGS 9896. ( Griffiths, RR; Lamb, RJ, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (34.48) | 18.7374 |
| 1990's | 25 (28.74) | 18.2507 |
| 2000's | 12 (13.79) | 29.6817 |
| 2010's | 16 (18.39) | 24.3611 |
| 2020's | 4 (4.60) | 2.80 |
| Authors | Studies |
|---|---|
| Pérez, T | 1 |
| Pardo, MC | 1 |
| Cabellos, Y | 1 |
| Peressini, M | 1 |
| Ureña-Vacas, I | 1 |
| Serrano, DR | 1 |
| González-Burgos, E | 1 |
| Zamboni, L | 1 |
| Lugoboni, F | 4 |
| Zandonai, T | 1 |
| Kalekin, RA | 1 |
| Saltykova, OV | 1 |
| Rodionova, GM | 1 |
| Gegechkori, VI | 1 |
| Orlova, AM | 1 |
| Costa, E | 1 |
| Sterzi, E | 1 |
| Tedeschi, F | 1 |
| Casari, R | 3 |
| Marini, P | 1 |
| Seifritz, E | 1 |
| Möller, HJ | 1 |
| Volz, HP | 1 |
| Müller, WE | 1 |
| Hopyan, T | 1 |
| Wacker, A | 1 |
| Schläfke, S | 1 |
| Kasper, S | 1 |
| Speerforck, S | 1 |
| Janowitz, D | 1 |
| Schomerus, G | 1 |
| Grabe, HJ | 1 |
| Hardman, MI | 1 |
| Sprung, J | 1 |
| Weingarten, TN | 1 |
| Faccini, M | 2 |
| Tamburin, S | 1 |
| Morbioli, L | 1 |
| Schylla, A | 1 |
| Scisło, P | 1 |
| Badura-Brzoza, K | 1 |
| Pasierb, N | 1 |
| Hoch, HJ | 1 |
| Gehring, C | 1 |
| Froberg, BA | 1 |
| Levine, M | 1 |
| Beuhler, MC | 1 |
| Judge, BS | 1 |
| Moore, PW | 1 |
| Engebretsen, KM | 1 |
| Mckeown, NJ | 1 |
| Rosenbaum, CD | 1 |
| Young, AC | 1 |
| Rusyniak, DE | 1 |
| Shin, JY | 2 |
| Lee, SH | 1 |
| Shin, SM | 1 |
| Kim, MH | 2 |
| Park, SG | 1 |
| Park, BJ | 2 |
| Park, HJ | 1 |
| Caloro, M | 1 |
| Calabrò, G | 1 |
| Kotzalidis, GD | 1 |
| Cuomo, I | 1 |
| Corkery, JM | 1 |
| Vento, AE | 1 |
| Lionetto, L | 1 |
| De Filippis, S | 1 |
| Ranieri, V | 1 |
| Lonati, D | 1 |
| Locatelli, CA | 1 |
| de Pisa, E | 1 |
| Di Tommaso, A | 1 |
| Girardi, P | 1 |
| Schifano, F | 1 |
| Cosci, F | 1 |
| Mansueto, G | 1 |
| Vo, KT | 1 |
| Horng, H | 1 |
| Smollin, CG | 1 |
| Benowitz, NL | 1 |
| El Balkhi, S | 1 |
| Chaslot, M | 1 |
| Picard, N | 1 |
| Dulaurent, S | 1 |
| Delage, M | 1 |
| Mathieu, O | 1 |
| Saint-Marcoux, F | 1 |
| Ator, NA | 3 |
| Atack, JR | 1 |
| Hargreaves, RJ | 1 |
| Burns, HD | 1 |
| Dawson, GR | 1 |
| Müller, H | 1 |
| Seifert, F | 1 |
| Maler, JM | 1 |
| Kornhuber, J | 1 |
| Sperling, W | 1 |
| Zacny, JP | 2 |
| Multz, AS | 1 |
| Chand, PK | 1 |
| Murthy, P | 1 |
| Jung, IK | 1 |
| Lee, HJ | 1 |
| Cho, BH | 1 |
| Panlilio, LV | 1 |
| Thorndike, EB | 1 |
| Schindler, CW | 1 |
| Skelton, KH | 1 |
| Gutman, DA | 1 |
| Thrivikraman, KV | 1 |
| Nemeroff, CB | 1 |
| Owens, MJ | 1 |
| van Hiele, LJ | 1 |
| González, ER | 1 |
| MacKinnon, GL | 1 |
| Parker, WA | 1 |
| McNicholas, LF | 1 |
| Martin, WR | 1 |
| Cherian, S | 1 |
| de Wit, H | 2 |
| Johanson, CE | 2 |
| Uhlenhuth, EH | 2 |
| Griffiths, RR | 8 |
| Lukas, SE | 1 |
| Lamb, RJ | 3 |
| Brady, JV | 1 |
| Cumin, R | 1 |
| Bonetti, EP | 1 |
| Scherschlicht, R | 1 |
| Haefely, WE | 1 |
| Kemper, N | 1 |
| Poser, W | 1 |
| Poser, S | 1 |
| Romach, M | 1 |
| Busto, U | 2 |
| Somer, G | 1 |
| Kaplan, HL | 2 |
| Sellers, E | 1 |
| Dabney, D | 1 |
| Deckert, J | 1 |
| Przuntek, H | 1 |
| Gleiter, CH | 1 |
| Tobias, JD | 1 |
| Deshpande, JK | 1 |
| Gregory, DF | 1 |
| Shenoy, RS | 1 |
| Sannerud, CA | 1 |
| Tesar, GE | 1 |
| Yaster, M | 1 |
| Kost-Byerly, S | 1 |
| Berde, C | 1 |
| Billet, C | 1 |
| Martínez-Cano, H | 1 |
| Vela-Bueno, A | 1 |
| de Iceta, M | 1 |
| Pomalima, R | 1 |
| Martínez-Gras, I | 1 |
| Saad, SF | 1 |
| Khayyal, MT | 1 |
| Attia, AS | 1 |
| Saad, ES | 1 |
| Way, BA | 1 |
| Walton, KG | 1 |
| Koenig, JW | 1 |
| Eveland, BJ | 1 |
| Scott, MG | 1 |
| Korkmaz, S | 2 |
| Carlsson, S | 1 |
| Wahlström, G | 2 |
| Prater, CD | 1 |
| Miller, KE | 1 |
| Zylstra, RG | 1 |
| Nath, C | 2 |
| Saxena, RC | 1 |
| Gupta, MB | 2 |
| Marc, B | 1 |
| Baudry, F | 1 |
| Vaquero, P | 1 |
| Zerrouki, L | 1 |
| Hassnaoui, S | 1 |
| Douceron, H | 1 |
| Shannon, M | 1 |
| Quang, LS | 1 |
| Weiss, AP | 1 |
| Murray, GB | 1 |
| Korsgaard, S | 1 |
| Fox, R | 1 |
| Harry, TV | 1 |
| Preston, KL | 3 |
| Wolf, B | 1 |
| Guarino, JJ | 2 |
| Sellers, EM | 1 |
| Schneiderman, JF | 1 |
| Romach, MK | 1 |
| Somer, GR | 1 |
| Miller, LG | 1 |
| Murphy, SM | 1 |
| Tyrer, P | 1 |
| Critchfield, TS | 1 |
| Griffiths, R | 1 |
| Benazzi, F | 1 |
| Nickel, B | 1 |
| Borbe, HO | 1 |
| Szelenyi, I | 1 |
| Bergman, U | 1 |
| Dahl, ML | 1 |
| Rydberg, U | 1 |
| Funderburk, FR | 2 |
| Liebson, IA | 2 |
| Bigelow, GE | 2 |
| Piot, O | 1 |
| Betschart, J | 1 |
| Stutzmann, JM | 1 |
| Blanchard, JC | 1 |
| Kirk, WT | 1 |
| Sanchez-Craig, M | 1 |
| Kay, G | 1 |
| Cappell, H | 1 |
| Crouch, G | 1 |
| Robson, M | 1 |
| Hallstrom, C | 1 |
| Barattini, M | 1 |
| Fantozzi, R | 1 |
| Masini, E | 1 |
| Mannaioni, PF | 1 |
| Pike, RF | 1 |
| Cole, JO | 2 |
| Orzack, MH | 2 |
| Friedman, L | 1 |
| Dessain, E | 1 |
| Bird, M | 1 |
| Beake, B | 1 |
| McEachern, J | 1 |
| Nutt, DJ | 1 |
| Costello, MJ | 1 |
| Craig, DF | 1 |
| McLeod, DR | 1 |
| Mackenzie, A | 1 |
| Nemeth-Coslett, R | 1 |
| Heritch, AJ | 1 |
| Capwell, R | 1 |
| Roy-Byrne, PP | 1 |
| van Sweden, B | 1 |
| Hoste, S | 1 |
| Roache, JD | 1 |
| Ross, M | 1 |
| Carr, AC | 1 |
| Fraser, AA | 1 |
| Ingram, IM | 1 |
10 reviews available for lorazepam and Chemical Dependence
| Article | Year |
|---|---|
Acute phenibut withdrawal: A comprehensive literature review and illustrative case report.
Topics: Akathisia, Drug-Induced; Baclofen; Cyproheptadine; Dexmedetomidine; Diphenhydramine; GABA-A Receptor | 2019 |
Ativan (Lorazepam).
Topics: Anti-Anxiety Agents; Humans; Lorazepam; Substance-Related Disorders | 2012 |
Benzodiazepine withdrawal syndrome: a literature review and evaluation.
Topics: Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Dose-Response Relationship, Drug; Humans; Lorazepam | 1982 |
The agitated patient, Part II: Pharmacologic treatment.
Topics: Akathisia, Drug-Induced; Drug Therapy, Combination; Emergencies; Haloperidol; Humans; Lorazepam; Neu | 1993 |
The management of opioid and benzodiazepine dependence in infants, children, and adolescents.
Topics: Adolescent; Analgesia, Patient-Controlled; Anti-Anxiety Agents; Child; Child, Preschool; Drug Admini | 1996 |
Outpatient detoxification of the addicted or alcoholic patient.
Topics: Alcohol Withdrawal Delirium; Alcoholic Intoxication; Ambulatory Care; Anti-Anxiety Agents; Chlordiaz | 1999 |
Gamma-hydroxybutyrate, gamma-butyrolactone, and 1,4-butanediol: a case report and review of the literature.
Topics: 4-Butyrolactone; Adjuvants, Anesthesia; Adolescent; Butylene Glycols; Emergency Medical Services; Fe | 2000 |
Chronic benzodiazepine administration: from the patient to the gene.
Topics: Alprazolam; Animals; Benzodiazepines; Clonazepam; Down-Regulation; Drug Tolerance; Flumazenil; Human | 1991 |
[Abuse potential of benzodiazepines. Sensible use means continuous follow-up].
Topics: Anti-Anxiety Agents; Follow-Up Studies; Humans; Lorazepam; Risk Factors; Substance-Related Disorders | 1990 |
Comparative study of the abuse liability of alprazolam, lorazepam, diazepam, methaqualone, and placebo.
Topics: Adolescent; Adult; Alprazolam; Arousal; Diazepam; Euphoria; Female; Humans; Lorazepam; Male; Methaqu | 1988 |
15 trials available for lorazepam and Chemical Dependence
| Article | Year |
|---|---|
No Abuse Potential of Silexan in Healthy Recreational Drug Users: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Central Nervous System Depressants; Cross-Over Studies; Doub | 2021 |
Characterizing the subjective, psychomotor, and physiological effects of a hydrocodone combination product (Hycodan) in non-drug-abusing volunteers.
Topics: Adult; Arousal; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Comb | 2003 |
Profiling the subjective, psychomotor, and physiological effects of tramadol in recreational drug users.
Topics: Adult; Blood Pressure; Cross-Over Studies; Double-Blind Method; Female; Humans; Illicit Drugs; Loraz | 2005 |
Where are all the tranquilizer junkies?
Topics: Anti-Anxiety Agents; Clinical Trials as Topic; Diazepam; Double-Blind Method; Humans; Lorazepam; Sub | 1983 |
The dependence potential of benzodiazepines.
Topics: Adult; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Lorazepam; M | 1984 |
Subjective and behavioral effects of diphenhydramine, lorazepam and methocarbamol: evaluation of abuse liability.
Topics: Adult; Cognition; Diphenhydramine; Dose-Response Relationship, Drug; Humans; Lorazepam; Male; Methoc | 1992 |
Comparative drug effects and abuse liability of lorazepam, buspirone, and secobarbital in nondependent subjects.
Topics: Adult; Affect; Attention; Buspirone; Dose-Response Relationship, Drug; Humans; Lorazepam; Male; Ment | 1992 |
A double-blind comparison of the effects of gradual withdrawal of lorazepam, diazepam and bromazepam in benzodiazepine dependence.
Topics: Adult; Anti-Anxiety Agents; Bromazepam; Diazepam; Dose-Response Relationship, Drug; Double-Blind Met | 1991 |
Evaluation of the abuse potential of the novel analgesic flupirtine maleate.
Topics: Adult; Affect; Aminopyridines; Analgesics; Arousal; Attention; Dose-Response Relationship, Drug; Dou | 1991 |
Evaluation of the abuse potential of methocarbamol.
Topics: Adolescent; Adult; Affect; Amnesia; Analysis of Variance; Dose-Response Relationship, Drug; Humans; | 1989 |
Cognitive-behavioural treatment for benzodiazepine dependence.
Topics: Cognition; Diazepam; Female; Follow-Up Studies; Humans; Lorazepam; Male; Substance-Related Disorders | 1986 |
Potential for abuse of alprazolam.
Topics: Alprazolam; Clinical Trials as Topic; Diazepam; Double-Blind Method; Humans; Lorazepam; Methaqualone | 1988 |
Comparative study of the abuse liability of alprazolam, lorazepam, diazepam, methaqualone, and placebo.
Topics: Adolescent; Adult; Alprazolam; Arousal; Diazepam; Euphoria; Female; Humans; Lorazepam; Male; Methaqu | 1988 |
Relative abuse liability of lorazepam and diazepam: an evaluation in 'recreational' drug users.
Topics: Adult; Cognition Disorders; Diazepam; Double-Blind Method; Humans; Lorazepam; Male; Psychomotor Diso | 1988 |
Lorazepam and meprobamate dose effects in humans: behavioral effects and abuse liability.
Topics: Adult; Affect; Analysis of Variance; Behavior; Dose-Response Relationship, Drug; Humans; Lorazepam; | 1987 |
63 other studies available for lorazepam and Chemical Dependence
| Article | Year |
|---|---|
Mental health and drug use in college students: Should we take action?
Topics: Anxiety; COVID-19; Depression; Humans; Lorazepam; Mental Health; Students; Substance-Related Disorde | 2023 |
Benzodiazepine abuse among athletes: Pain relief or just a weapon against insomnia? A clinical case study.
Topics: Adult; Athletes; Female; Humans; Lorazepam; Pain; Pain Management; Sleep; Sleep Initiation and Maint | 2019 |
[On the issue of the detection of pregabalin and lorazepam in the cases of their joint presence for the purpose of chemical toxicological studies].
Topics: Chromatography, Gas; Humans; Lorazepam; Poisoning; Pregabalin; Substance-Related Disorders | 2020 |
Can oral formulation increase the risk of lormetazepam abuse?
Topics: Administration, Oral; Ethanol; Humans; Hypnotics and Sedatives; Lorazepam; Risk Factors; Substance-R | 2021 |
[Psychosis, Intoxication or Serotonin Syndrome? - A 20-Year Old Male with Ziprasidone und Sertraline].
Topics: Depressive Disorder, Major; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Lor | 2017 |
High-dose lormetazepam dependence: strange case of Dr. Jekyll and Mr. Hyde.
Topics: Adult; Benzodiazepines; Female; Humans; Italy; Lorazepam; Male; Middle Aged; Prevalence; Retrospecti | 2019 |
[Description of a patient with schizophrenia and coexisting megadose lorazepam dependence with slightly expressed withdrawl symptoms during drug reduction. A case report].
Topics: Adult; Anti-Anxiety Agents; Anxiety Disorders; Humans; Lorazepam; Male; Schizophrenia, Paranoid; Sub | 2012 |
[High-dose zolpidem dependence].
Topics: Alcoholism; Benzodiazepines; Comorbidity; Dose-Response Relationship, Drug; Drug Tolerance; Female; | 2013 |
Acute Methylenedioxypyrovalerone Toxicity.
Topics: Adolescent; Adult; Age Factors; Alkaloids; Benzodioxoles; Diagnosis, Dual (Psychiatry); Female; Huma | 2015 |
Prescribing patterns of the four most commonly used sedatives in endoscopic examination in Korea: propofol, midazolam, diazepam, and lorazepam.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Diazepam; Drug Prescriptions; Drug Utilization Review; E | 2015 |
Increased use in propofol and reported patterns of adverse events among anesthetics in Korea.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Anesthetics, Intravenous; Child; C | 2015 |
Use of benzylglycinamide by a HIV-seropositive polysubstance user: The changing pattern of novel psychoactive substance use among youths.
Topics: Adult; Anti-Anxiety Agents; Anti-Retroviral Agents; Antipsychotic Agents; Female; Glycine; HIV Infec | 2016 |
Socio-demographic and clinical characteristics of benzodiazepine long-term users: Results from a tertiary care center.
Topics: Adult; Anxiety Disorders; Benzodiazepines; Dose-Response Relationship, Drug; Female; Humans; Long-Te | 2016 |
Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose.
Topics: Adult; Carisoprodol; Dexmedetomidine; Drug Overdose; Fentanyl; Haloperidol; Humans; Hypnotics and Se | 2017 |
Characterization and identification of eight designer benzodiazepine metabolites by incubation with human liver microsomes and analysis by a triple quadrupole mass spectrometer.
Topics: Adult; Benzodiazepines; Chromatography, Liquid; Designer Drugs; Humans; Lorazepam; Male; Microsomes, | 2017 |
Reducing abuse liability of GABAA/benzodiazepine ligands via selective partial agonist efficacy at alpha1 and alpha2/3 subtypes.
Topics: Animals; Behavior, Animal; Binding Sites; Brain; Dose-Response Relationship, Drug; GABA Agonists; GA | 2010 |
Agomelatine reduces craving in benzodiazepine addicts: a follow-up examination of three patients.
Topics: Acetamides; Adult; Antidepressive Agents; Behavior, Addictive; Benzodiazepines; Female; Follow-Up St | 2012 |
Prolonged dexmedetomidine infusion as an adjunct in treating sedation-induced withdrawal.
Topics: Acinetobacter Infections; Adult; Analgesics, Opioid; Dexmedetomidine; Fentanyl; Humans; Hypnotics an | 2003 |
Megadose lorazepam dependence.
Topics: Adult; Drug Tolerance; Humans; Hypnotics and Sedatives; Lorazepam; Substance-Related Disorders | 2003 |
Persistent psychotic disorder in an adolescent with a past history of butane gas dependence.
Topics: Adolescent; Antipsychotic Agents; Butanes; Diagnostic and Statistical Manual of Mental Disorders; Ha | 2004 |
Lorazepam reinstates punishment-suppressed remifentanil self-administration in rats.
Topics: Analgesics, Opioid; Animals; Anti-Anxiety Agents; Conditioning, Operant; Dose-Response Relationship, | 2005 |
The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Flumazenil; Gene Expression; Hypnotics and | 2007 |
[Can lorazepam be distinguished from other short-acting benzodiazepines in regard to brain damage and withdrawal symptoms?].
Topics: Anti-Anxiety Agents; Humans; Lorazepam; Substance Withdrawal Syndrome; Substance-Related Disorders | 1981 |
Physical dependence on diazepam and lorazepam in the dog.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Dogs; Female; Gait; Humans; Lorazepam; Pyrazole | 1983 |
Benzodiazepines: drug discrimination and physiological dependence.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Bromazepam; Diazepam; Discrimination Lear | 1984 |
Drug preference in humans: lorazepam.
Topics: Adult; Affect; Arousal; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Lorazepam; Male; | 1984 |
Precipitated and spontaneous withdrawal in baboons after chronic dosing with lorazepam and CGS 9896.
Topics: Animals; Benzodiazepinones; Flumazenil; Humans; Lorazepam; Male; Papio; Pyrazoles; Substance Withdra | 1984 |
Use of the specific benzodiazepine antagonist, Ro 15-1788, in studies of physiological dependence on benzodiazepines.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Cats; Diazepam; Female; Flumazenil; Humans; Lorazepam; | 1982 |
Systematic review of the benzodiazepines. Guidelines for data sheets on diazepam, chlordiazepoxide, medazepam, clorazepate, lorazepam, oxazepam, temazepam, triazolam, nitrazepam, and flurazepam. Committee on the Review of Medicines.
Topics: Benzodiazepines; Chlordiazepoxide; Clorazepate Dipotassium; Diazepam; Flurazepam; Humans; Lorazepam; | 1980 |
[Benzodiazepine dependence: addiction potential of the benzodiazepines is greater than previously assumed (author's transl)].
Topics: Alcoholism; Barbiturates; Benzodiazepines; Female; Hospitals, Psychiatric; Humans; Lorazepam; Male; | 1980 |
Clinical aspects of chronic use of alprazolam and lorazepam.
Topics: Alprazolam; Ambulatory Care; Anxiety Disorders; Depressive Disorder; Drug Administration Schedule; F | 1995 |
Workplace deviance among nurses. The influence of work group norms on drug diversion and/or use.
Topics: Adult; Anti-Anxiety Agents; Attitude of Health Personnel; Drug and Narcotic Control; Female; Humans; | 1995 |
Organic anxiety syndrome after withdrawal of atenolol.
Topics: Aged; Anxiety Disorders; Atenolol; Diltiazem; Humans; Hypertension; Lorazepam; Male; Substance Withd | 1994 |
Outpatient therapy of iatrogenic drug dependency following prolonged sedation in the pediatric intensive care unit.
Topics: Child; Female; Fentanyl; Humans; Iatrogenic Disease; Infant; Lorazepam; Male; Methadone; Midazolam; | 1994 |
Pitfalls in the treatment of jimsonweed intoxication.
Topics: Adolescent; Contraindications; Datura stramonium; Drug Therapy, Combination; Haloperidol; Humans; Lo | 1994 |
Behavioral pharmacology of tandospirone in baboons: chronic administration and withdrawal, self-injection and drug discrimination.
Topics: Animals; Anti-Anxiety Agents; Arousal; Buspirone; Cocaine; Discrimination Learning; Dose-Response Re | 1993 |
Behavioral effects of pentobarbital, lorazepam, ethanol and chlorpromazine substitution in pentobarbital-dependent baboons.
Topics: Animals; Behavior, Animal; Chlorpromazine; Ethanol; Lorazepam; Male; Papio; Pentobarbital; Substance | 1993 |
Benzodiazepine withdrawal syndrome seizures.
Topics: Adult; Anti-Anxiety Agents; Female; Flunitrazepam; Heroin Dependence; Humans; Hypnotics and Sedative | 1995 |
Influence of certain calcium-channel blockers on some aspects of lorazepam-dependence in mice.
Topics: Animals; Brain Chemistry; Calcium Channel Blockers; Diltiazem; Dopamine; Flunarizine; Isradipine; Lo | 1997 |
Comparison between the CEDIA and EMIT II immunoassays for the determination of benzodiazepines.
Topics: Benzodiazepines; Gas Chromatography-Mass Spectrometry; Humans; Immunoassay; Lorazepam; Medical Recor | 1998 |
Development of physical dependence to lorazepam in rats: the effects of repeated short treatments, dose and age.
Topics: Age Factors; Animals; Dose-Response Relationship, Drug; Electroencephalography; Hexobarbital; Hypnot | 1998 |
Physical dependence after benzodiazepine treatments in rats: Comparison of short and long treatments with diazepam and lorazepam.
Topics: Animals; Anti-Anxiety Agents; Arousal; Brain; Diazepam; Dose-Response Relationship, Drug; Drug Admin | 1999 |
Effect of dopamine agonists and antagonists on the lorazepam withdrawal syndrome in rats.
Topics: Acoustic Stimulation; Aggression; Animals; Anti-Anxiety Agents; Dopamine Agonists; Dopamine Antagoni | 2000 |
Sexual assault under benzodiazepine submission in a Paris suburb.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Benzodiazepines; Cocaine; Dronabinol; Estazolam; Female; Flu | 2000 |
Abuse of topical analgesic.
Topics: Administration, Topical; Alcoholism; Analgesics, Non-Narcotic; Delirium; Fentanyl; Humans; Infusions | 2001 |
Role of central histaminergic system in lorazepam withdrawal syndrome in rats.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Epilepsy, Reflex; Histamine; Histamine Agonists; | 2001 |
[Abuse of lorazepam (Temesta)].
Topics: Anti-Anxiety Agents; Female; Humans; Hysteria; Lorazepam; Middle Aged; Substance-Related Disorders | 1976 |
Abuse of benzodiazepines.
Topics: Adult; Alcoholism; Anti-Anxiety Agents; Humans; Lorazepam; Male; Substance-Related Disorders | 1978 |
Abuse of benzodiazepines.
Topics: Alcoholism; Anti-Anxiety Agents; Chlormethiazole; Diazepam; Drug Synergism; Humans; Lorazepam; Male; | 1978 |
Behavioral and subjective effects of buspirone and lorazepam in sedative abusers: supra-therapeutic doses.
Topics: Adult; Behavior; Buspirone; Double-Blind Method; Humans; Hypnotics and Sedatives; Lorazepam; Male; P | 1990 |
Lorazepam, amitriptyline, and sulpiride: withdrawal effects.
Topics: Amitriptyline; Anxiety Disorders; Depressive Disorder; Drug Therapy, Combination; Female; Humans; Lo | 1991 |
Investigations with the novel non-opioid analgesic flupirtine in regard to possible benzodiazepine-like abuse inducing potential.
Topics: Aminopyridines; Analgesics; Animals; Anti-Anxiety Agents; Binding, Competitive; Body Weight; Brain C | 1990 |
Cyclopyrrolones, unlike some benzodiazepines, do not induce physical dependence in mice.
Topics: Animals; Azabicyclo Compounds; Carbolines; Convulsants; Diazepam; Disease Models, Animal; Flunitraze | 1990 |
Benzodiazepine dependent patients and their psychological treatment.
Topics: Adaptation, Psychological; Adult; Anti-Anxiety Agents; Behavior Therapy; Combined Modality Therapy; | 1988 |
[Abuse of licit drugs in heroin addicts].
Topics: Adolescent; Adult; Anti-Anxiety Agents; Diazepam; Female; Flunitrazepam; Heroin Dependence; Humans; | 1987 |
Cocaine withdrawal. An effective three-drug regimen.
Topics: Amantadine; Cocaine; Humans; Lorazepam; Substance Withdrawal Syndrome; Substance-Related Disorders; | 1989 |
Rapid induction of lorazepam dependence and reversal with flumazenil.
Topics: Animals; Carbolines; Flumazenil; Lorazepam; Male; Mice; Mice, Inbred Strains; Seizures; Substance-Re | 1988 |
Withdrawal from benzodiazepines of short half-life.
Topics: Adult; Female; Humans; Lorazepam; Substance Withdrawal Syndrome; Substance-Related Disorders | 1988 |
A case of psychosis and delirium following withdrawal from triazolam.
Topics: Delirium; Humans; Lorazepam; Male; Middle Aged; Psychoses, Substance-Induced; Substance Withdrawal S | 1987 |
[Old and on the bottle again: a double stigma].
Topics: Aged; Aged, 80 and over; Alcoholism; Female; Humans; Lorazepam; Male; Substance-Related Disorders | 1987 |
Lorazepam-associated drug dependence.
Topics: Humans; Lorazepam; Substance-Related Disorders | 1986 |
Lorazepam dependence and chronic psychosis.
Topics: Humans; Lorazepam; Male; Psychoses, Substance-Induced; Substance-Related Disorders | 1986 |
Lorazepam dependence and chronic psychosis.
Topics: Adult; Diagnosis, Differential; Humans; Lorazepam; Male; Psychoses, Substance-Induced; Schizophrenia | 1985 |