lorazepam and Anxiety studies

Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

Excerpt	Relevance	Reference
"The anxiety difference was complex in that the interaction of lorazepam and UGT2B15 genotype status also was dependent on the joint effect of patient sex and preoperative anxiety score (F = 7."	9.22	Implication of UGT2B15 Genotype Polymorphism on Postoperative Anxiety Levels in Patients Receiving Lorazepam Premedication. ( Duivenvoorden, HJ; Klimek, M; Mijderwijk, H; Stolker, RJ; van Beek, S; van Schaik, RH, 2016)
"Chlordesmethyldiazepam a long-acting benzodiazepine was compared with lorazepam a short-acting one in a double-blind placebo cross-over study against generalized anxiety disorders."	9.06	Double-blind placebo cross-over study of long-acting (chlordesmethyldiazepam) versus short-acting (lorazepam) benzodiazepines in generalized anxiety disorders. ( Benetello, P; Bertin, I; Colombo, G; Furlanut, M, 1989)
"Lormetazepam significantly reduced anxiety during local anaesthesia when compared with a placebo control group."	9.05	[Preoperative anxiolysis with lormetazepam. A model for measuring anxiety]. ( Doenicke, A; Ott, H; Suttmann, H; Ulsamer, B, 1983)
"A four-week double-blind comparison between lorazepam and placebo involving 60 patients with anxiety revealed that lorazepam in a mean dose of approximately 3 mg on a b."	9.04	A study in the management of anxiety with lorazepam. ( Cancellaro, LA; Ellison, RJ, 1978)
"Fifty-eight neurotic patients with intense anxiety were treated with either lorazepam or diazepam in a double blind between-patients trial."	9.04	Lorazepam and diazepam in the treatment of neurotic anxiety: a double-blind trial. ( Perez-Lopez, R; Valarino, F, 1976)
"Sixty-two adults with a current diagnosis of significant hypertension and accompanying moderate to severe anxiety were medicated with lorazepam or with placebo for a period of 4 weeks."	9.04	The effect of lorazepam on hypertension-associated anxiety: a double-blind study. ( Hart, WL; Parmley, LF, 1978)
"The effectiveness of lorazepam was assessed under double-blind conditions in 70 ambulant patients suffering from anxiety associated with gastrointestinal symptomatology."	9.04	A clinical assessment of lorazepam in the treatment of anxiety associated with gastrointestinal symptomatology. ( Berkowitz, JM, 1978)
"Using a common protocol, 9 gastroenterologists assessed the comparative antianxiety efficacy of lorazepam and placebo under double-blind conditions in 48 patients with moderate to severe anxiety associated with chronic enteritis and ulcerative colitis."	9.04	Lorazepam in anxiety associated with chronic enteritis and ulcerative colitis. ( Stokes, DK, 1978)
"Ninety-five adult outpatients suffering from moderate to severe anxiety were randomly assigned to treatment with lorazepam or placebo in a double-blind four-week study."	9.04	Lorazepam, a new benzodiazepine derivative, in the treatment of anxiety: a double-blind clinical evaluation. ( McCurdy, L, 1979)
"A growing number of informal caregivers (IFCs) manage hospice patients' anxiety by administering lorazepam (Ativan), yet little is known about prescribing practices in home care or the extent to which IFCs carry out regimens."	8.02	Informal Caregivers' Administration of Hospice Prescribed Lorazepam to Homecare Patients With Anxiety. ( Ropri, F; Weisse, CS, 2021)
"After the preliminary successful use of injectable lorazepam in calming 20 patients who presented with acute anxiety crises, a formal study of 115 other such patients was carried out."	7.66	Management of acute anxiety syndrome with parenterally administered lorazepam. ( Gómez-Lozano, P, 1978)
"A nonblind clinical study was carried out by administering Lorazepam at a low dosage to patients with a light to moderate state of reactive anxiety."	7.65	[Use of an anxiolytic agent (lorazepam) in low doses in the treatment of anxiety states]. ( Bocci, U; Inga, EF; Luzi, T, 1977)
"Panic attacks were defined using the panic symptom scale (PSS)."	6.76	One milligram of lorazepam does not decrease anxiety induced by CCK-4 in healthy volunteers: investigation of neural correlates with BOLD MRI. ( Demazières, A; Erb, G; Hode, Y; Luthringer, R; Mathis, A; Namer, IJ; Schunck, T, 2011)
"Signs of respiratory depression were not found."	6.76	Dyspnoea associated with anxiety--symptomatic therapy with opioids in combination with lorazepam and its effect on ventilation in palliative care patients. ( Clemens, KE; Klaschik, E, 2011)
"A double-blind crossover trial comparing lorazepam at two dosage levels with amylobarbitone supported previous reports of the effective anxiolytic action of the drug."	6.64	A comparison of high- and low-dose lorazepam with amylobarbitone in patients with anxiety states. ( McClelland, HA; Newell, DJ; Schapira, K, 1977)
"Diazepam demonstrated a statistically significant, sustained reduction in anxiety levels compared with placebo ( p = ."	5.69	Efficacy and Safety of Anxiolytics in Mohs Micrographic Surgery: A Randomized, Double-Blinded, Placebo-Controlled Trial. ( Guo, D; Kossintseva, I; Zloty, DM, 2023)
" injection of lorazepam and atropine, the dosage being adjusted to body weight."	5.26	Clinical trial with lorazepam in pre-operative anxiety. ( Baute, L, 1977)
"To compare pain and anxiety levels between two prophylactic treatment regimens, a combination of sublingual tramadol Hcl with oral lorazepam and oral diazepam only."	5.15	Prophylactic analgesia before percutaneous liver biopsy: a clinical comparative study. ( Baruch, Y; Eisenberg, E; Kramskay, R; Tansky, A; Veitsman, E, 2011)
") lorazepam and hydromorphone reduces pain and anxiety during BMBA."	5.09	A randomized, placebo-controlled study of outpatient premedication for bone marrow biopsy in adults with lymphoma. ( Habermann, TM; Inwards, DJ; Schroeder, G; Wilson, PR; Witzig, TE; Wolanskyj, AP, 2000)
"Two doses of two very similar benzodiazepines (oxazepam 15 and 30 mg: lorazepam 1 and 2 mg) and placebo were compared 4 h post-administration on a competitive reaction time task designed to measure behavioural aggression."	5.06	Differential effects of oxazepam and lorazepam on aggressive responding. ( Bond, A; Lader, M, 1988)
"In 60 patients undergoing a curettage in thiopentone induced inhalation anaesthesia with enflurane and N2O/O2 = 2:1, the effects of oral premedication (2 h before anaesthesia) with 30 mg morphine (MST 30) (n = 21), 1 mg lormetazepam (Noctamid) (n = 19) and placebo (n = 21) on psychological (anxiety, depression and asthenia), physiological (blood pressure, heart and respiratory rate) and pain parameters (visual analogue scale, analgesic consumption) were investigated."	5.06	[Effect and side effects of oral morphine, lormetazepam and placebos as premedication]. ( Hartung, M; Hettenbach, A; Krug, C; Tolksdorf, W, 1987)
"Chlordesmethyldiazepam a long-acting benzodiazepine was compared with lorazepam a short-acting one in a double-blind placebo cross-over study against generalized anxiety disorders."	5.06	Double-blind placebo cross-over study of long-acting (chlordesmethyldiazepam) versus short-acting (lorazepam) benzodiazepines in generalized anxiety disorders. ( Benetello, P; Bertin, I; Colombo, G; Furlanut, M, 1989)
"The effects of 3 mg lorazepam on polysomnographic recordings, performance, anxiety, and perceived sleep were examined."	5.05	Effects of lorazepam and its withdrawal on sleep, performance, and subjective state. ( Parwatikar, S; Schweitzer, PK; Walsh, JK, 1983)
"Lormetazepam significantly reduced anxiety during local anaesthesia when compared with a placebo control group."	5.05	[Preoperative anxiolysis with lormetazepam. A model for measuring anxiety]. ( Doenicke, A; Ott, H; Suttmann, H; Ulsamer, B, 1983)
"The effectiveness of lorazepam was assessed under double-blind conditions in 70 ambulant patients suffering from anxiety associated with gastrointestinal symptomatology."	5.04	A clinical assessment of lorazepam in the treatment of anxiety associated with gastrointestinal symptomatology. ( Berkowitz, JM, 1978)
"Using a common protocol, 9 gastroenterologists assessed the comparative antianxiety efficacy of lorazepam and placebo under double-blind conditions in 48 patients with moderate to severe anxiety associated with chronic enteritis and ulcerative colitis."	5.04	Lorazepam in anxiety associated with chronic enteritis and ulcerative colitis. ( Stokes, DK, 1978)
"Sixty-two adults with a current diagnosis of significant hypertension and accompanying moderate to severe anxiety were medicated with lorazepam or with placebo for a period of 4 weeks."	5.04	The effect of lorazepam on hypertension-associated anxiety: a double-blind study. ( Hart, WL; Parmley, LF, 1978)
"The World Health Organization recommends that anxiety, depression, agitation and delirium at end of life should be treated with drugs such as lorazepam, diazepam, midazolam and haloperidol."	3.83	Look again at psychedelic drugs. ( Cameron, R, 2016)
"The benzodiazepine lorazepam is widely utilized in the treatment of elderly individuals with anxiety disorders and related conditions."	3.81	Adverse performance effects of acute lorazepam administration in elderly long-term users: pharmacokinetic and clinical predictors. ( Bruno, D; Greenblatt, DJ; Lee, SH; Petkova, E; Pomara, N; Sidtis, JJ; Silber, T, 2015)
"Pretreatment with R121919 attenuated the subsequent HPA axis activation, behavioral measures of anxiety, and expression of the CRF gene in the paraventricular nucleus of the hypothalamus, as measured by CRF heteronuclear RNA, which occurs after flumazenil-precipitation of withdrawal from the BZ, lorazepam."	3.74	The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal. ( Gutman, DA; Nemeroff, CB; Owens, MJ; Skelton, KH; Thrivikraman, KV, 2007)
"To study an emotional status and quality of life (QL) in patients with coronary heart disease (CHD) and anxiety, to evaluate efficacy of anxiolytic drug lorazepam (lorafen) in such patients."	3.74	[The course of coronary heart disease and quality of life in patients with anxiety of different degree]. ( Ibatov, AD, 2007)
" The case presentation illustrates the role of pregabalin in successful medical management of this chronic pain disorder, as well as the management of common psychiatric morbidities associated with this condition."	3.74	Pregabalin-induced remission in a 62-year-old woman with a 20-year history of vulvodynia. ( Jerome, L, 2007)
"QUESTIONOne of my patients suffers from anxiety and was using lorazepam to treat it."	3.70	Can we use anxiolytics during pregnancy without anxiety? ( Addis, A; Dolovich, LR; Einarson, TR; Koren, G, 2000)
"In 156 experiments performed on 41 cats with adequate experimental models of pseudoneurotic conditions, states of anxiety due to an electrostimulation of the hypothalamus through implanted electrodes and an emotional stress due to a conflict situation the authors compared the individual traits of the psychotropic activity of lorazepam, diazepam, chlordiazepoxide, oxazepam, nirazepam."	3.66	[Psychophysiologic characteristics of the individual psychotropic activity of benzodiazepine derivatives under experimental conditions]. ( Kozlovskaia, MM; Val'dman, AV, 1978)
"After the preliminary successful use of injectable lorazepam in calming 20 patients who presented with acute anxiety crises, a formal study of 115 other such patients was carried out."	3.66	Management of acute anxiety syndrome with parenterally administered lorazepam. ( Gómez-Lozano, P, 1978)
"A clinical study was carried out in 73 neoplastic patients suffering from anxiety and other emotional upsets to assess the effectiveness and tolerance of lorazepam."	3.65	Anxiety therapy in the neoplastic patient. ( Battelli, T; Bonsignori, M; Manocchi, P; Rossi, G, 1976)
"Change in anxiety was evaluated as a function of medication, disorder, time, potency, lipophilicity, and standardized dose and compared among benzodiazepines."	3.01	Pharmacologic predictors of benzodiazepine response trajectory in anxiety disorders: a Bayesian hierarchical modeling meta-analysis. ( Mills, JA; Stimpfl, JN; Strawn, JR, 2023)
"Panic attacks were defined using the panic symptom scale (PSS)."	2.76	One milligram of lorazepam does not decrease anxiety induced by CCK-4 in healthy volunteers: investigation of neural correlates with BOLD MRI. ( Demazières, A; Erb, G; Hode, Y; Luthringer, R; Mathis, A; Namer, IJ; Schunck, T, 2011)
"Signs of respiratory depression were not found."	2.76	Dyspnoea associated with anxiety--symptomatic therapy with opioids in combination with lorazepam and its effect on ventilation in palliative care patients. ( Clemens, KE; Klaschik, E, 2011)
"Lorazepam was administered before each rest period in increasing doses of 0."	2.67	Dose-dependent effects of intravenous lorazepam on cardiovascular activity, plasma catecholamines and psychological function during rest and mental stress. ( Boomsma, F; Moleman, P; Tulen, JH; van den Heuij, VJ; van Steenis, HG, 1991)
"Four consecutive trials were undertaken to study lorazepam at each of three dosage levels and diphenhydramine when used in combination with iv metoclopramide and dexamethasone in patients receiving cisplatin at 120 mg/m2."	2.66	Consecutive dose-finding trials adding lorazepam to the combination of metoclopramide plus dexamethasone: improved subjective effectiveness over the combination of diphenhydramine plus metoclopramide plus dexamethasone. ( Clark, RA; Fiore, JJ; Gralla, RJ; Groshen, S; Kelsen, DP; Kris, MG; Tyson, LB, 1985)
"Some withdrawal symptoms were distinct from those of anxiety (e."	2.66	Withdrawal reaction after long-term therapeutic use of benzodiazepines. ( Busto, U; Cappell, H; Naranjo, CA; Sanchez-Craig, M; Sellers, EM; Sykora, K, 1986)
"Triazolam and lorazepam were each associated with a significant reduction in anxiety compared to the initial assessment, whereas placebo had no anxiolytic effect."	2.66	Triazolam premedication. A comparison with lorazepam and placebo in gynaecological patients. ( Blogg, CE; Halifax, R; Hollands, MA; Thomas, D; Tipping, T, 1986)
"Lormetazepam (1 and 2 mg) was tested against flurazepam (30 mg) and placebo in 60 patients (15 per treatment group) with initial, intermediate, or late insomnia."	2.65	Comparative study of lormetazepam and flurazepam in the treatment of insomnia. ( Melo de Paula, AJ, 1984)
"Lorazepam did produce a transient effect on the neonatal respiratory rate and initially the babies had a reduced score on the Brazelton Assessment System."	2.65	Use of lorazepam as a premedicant for caesarean section. An evaluation of its effects on the mother and the neonate. ( Houghton, DJ, 1983)
"Lorazepam 2."	2.64	Comparative study of two long-acting tranquillizers for oral premedication. ( Dodson, ME; Eastley, RJ, 1978)
" Present findings suggested that 3 mg/day of lorazepam may be too high a dosage for mildly anxious patients, while 15 mg/day of diazepam seems an appropriate dosage for mildly anxious patients but may be too low a dosage for highly anxious patients."	2.64	Lorazepam and diazepam in anxious outpatients. A controlled study. ( Case, WG; Chung, HR; Morris, RJ; Pereira-Ogan, J; Rickels, K; Rosenfeld, H; Segal, A, 1976)
"A double-blind crossover trial comparing lorazepam at two dosage levels with amylobarbitone supported previous reports of the effective anxiolytic action of the drug."	2.64	A comparison of high- and low-dose lorazepam with amylobarbitone in patients with anxiety states. ( McClelland, HA; Newell, DJ; Schapira, K, 1977)
"All four of the reviewed cases with myokymia of the shoulders were intubated and none without it were intubated."	1.35	Fasciculations after rattlesnake envenomations: a retrospective statewide poison control system study. ( Cantrell, FL; Vohra, R; Williams, SR, 2008)
"Diazepam was used as a positive control."	1.35	Evaluation of anxiolytic-like effects of some short-acting benzodiazepine hypnotics in mice. ( Kamei, C; Nishino, T; Takechi, K; Takeuchi, T, 2008)
" Demographic data, time in ED, and dosage of each medication given were abstracted."	1.35	Inadequate provision of postintubation anxiolysis and analgesia in the ED. ( Bonomo, JB; Butler, AS; Lindsell, CJ; Venkat, A, 2008)
"Withdrawal from the neurosteroid 3alpha,5alpha-allopregnanolone after chronic administration of progesterone increases anxiety in female rats and up-regulates the alpha4 subunit of the GABA(A) receptor (GABA(A)-R) in the hippocampus."	1.31	Progesterone withdrawal increases the alpha4 subunit of the GABA(A) receptor in male rats in association with anxiety and altered pharmacology - a comparison with female rats. ( Gong, QH; Gulinello, M; Smith, SS, 2002)
") was antagonized by the chronic administration of lorazepam as well as sodium valproate, a GABA agonist."	1.28	The anxiogenic-like effects of pentylenetetrazole in mice treated chronically with carbamazepine or valproate. ( de Angelis, L, 1992)
"Oral lorazepam is a commonly used premedicant both locally and abroad."	1.28	Delayed recovery following lorazepam premedication. ( Aun, LT; Inbasegaran, K, 1990)
"Lorazepam has as its predominant advantage over other benzodiazepines the ability to produce anterograde amnesia reliably and for a relatively long duration."	1.27	Clinical pharmacology of lorazepam. ( Blitt, CD, 1983)
"Lorazepam and diazepam were both unsatisfactory as sedatives for patients having Caesarean Section."	1.26	Lorazepam and diazepam as adjuncts to epidural anaesthesia for caesarean section. ( Cumming, M; Ong, BY; Palahniuk, RJ; Pickering, BG, 1982)
" The equipotent dosage to 10 mg prazepam seems to be 5 mg."	1.26	Classification and assessment of cerebral bioavailability of lopirazepam (D-12524) by quantitative EEG and psychometric analysis. ( Grünberger, J; Linzmayer, L; Saletu, B; Stadler, R, 1980)

Research

Studies (172)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

Quality of Recovery Score

Timeframe	Studies, this research(%)	All Research%
pre-1990	92 (53.49)	18.7374
1990's	21 (12.21)	18.2507
2000's	29 (16.86)	29.6817
2010's	21 (12.21)	24.3611
2020's	9 (5.23)	2.80

Authors	Studies
Ross, TM	1
Battista, K	1
Bignan, GC	1
Brenneman, DE	1
Connolly, PJ	1
Liu, J	1
Middleton, SA	1
Orsini, M	1
Reitz, AB	1
Rosenthal, DI	1
Scott, MK	1
Vaidya, AH	1
Stimpfl, JN	1
Mills, JA	1
Strawn, JR	1
Wolmarans, W	1
Prinsloo, M	1
Seedat, S	1
Stein, DJ	1
Harvey, BH	1
de Brouwer, G	1
Pérez, T	1
Pardo, MC	1
Cabellos, Y	1
Peressini, M	1
Ureña-Vacas, I	1
Serrano, DR	1
González-Burgos, E	1
Guo, D	1
Zloty, DM	1
Kossintseva, I	1
Chen, Y	1
Maitra, A	1
Duignan, KM	1
Quinn, AM	1
Matson, AM	1
Chen, C	1
Martínez, RM	1
Liao, TT	1
Chen, CY	1
Yang, CY	1
Cheng, Y	1
Ropri, F	1
Weisse, CS	1
Korn, CW	1
Vunder, J	1
Miró, J	1
Fuentemilla, L	1
Hurlemann, R	1
Bach, DR	1
Bregstein, JS	1
Wagh, AM	1
Tsze, DS	1
Demirhan, A	1
Velioglu, Y	1
Yoldas, H	1
Karagoz, I	1
Cosgun, M	1
Caliskan, D	1
Yildiz, I	1
Bilgi, M	1
Erdem, K	1
Mijderwijk, H	2
van Beek, S	2
Klimek, M	2
Duivenvoorden, HJ	2
Grüne, F	1
Stolker, RJ	2
Nishiyama, A	1
Matsumoto, H	1
Roden, E	1
Walder, B	1
Pomara, N	1
Lee, SH	1
Bruno, D	1
Silber, T	1
Greenblatt, DJ	1
Petkova, E	1
Sidtis, JJ	1
Chen, F	1
Chen, S	1
Liu, S	1
Zhang, C	1
Peng, G	1
Ramirez, K	1
Niraula, A	1
Sheridan, JF	1
Brady, KT	1
Cameron, R	1
van Schaik, RH	1
Richards, JR	1
Lange, RA	1
Arnold, TC	1
Horowitz, BZ	1
Bonnet, U	1
Ringel, P	1
Nishino, T	1
Takeuchi, T	1
Takechi, K	1
Kamei, C	1
Schunck, T	2
Mathis, A	2
Erb, G	2
Namer, IJ	2
Demazières, A	2
Luthringer, R	2
Humber, N	1
Perkins, AM	1
Ettinger, U	1
Davis, R	1
Foster, R	1
Williams, SC	1
Corr, PJ	1
Hode, Y	1
Clemens, KE	1
Klaschik, E	1
Bailey, JE	2
Papadopoulos, A	2
Diaper, A	2
Phillips, S	1
Schmidt, M	1
van der Ark, P	1
Dourish, CT	2
Dawson, GR	2
Nutt, DJ	2
Kramskay, R	1
Tansky, A	1
Eisenberg, E	1
Veitsman, E	1
Baruch, Y	1
de Oliveira, DC	1
Chagas, MH	1
Garcia, LV	1
Crippa, JA	1
Zuardi, AW	1
Rich, AS	1
Mar, A	1
Spreekmeester, E	1
Rochford, J	1
Gulinello, M	2
Gong, QH	1
Smith, SS	2
Leo, SW	1
Au Eong, KG	1
Rengaraj, V	1
Radhakrishnan, M	1
Wiebe, E	1
Podhradsky, L	1
Dijak, V	1
Lang, AP	1
de Angelis, L	3
Zeller, A	1
Handschin, D	1
Gyr, N	1
Martina, B	1
Battegay, E	1
James, JJ	1
Wilson, AR	1
Evans, AJ	1
Burrell, H	1
Cornford, EJ	1
Hamilton, LJ	1
Graham, SJ	1
Scaife, JC	1
Langley, RW	1
Bradshaw, CM	1
Szabadi, E	1
Xi, L	1
Crumley, T	1
Calder, N	1
Gottesdiener, K	1
Wagner, JA	1
Giersch, A	1
Vidailhet, P	1
Nguyen, N	1
Fakra, E	1
Pradel, V	1
Jouve, E	1
Alquier, C	1
Le Guern, ME	1
Micallef, J	1
Blin, O	1
Skelton, KH	1
Gutman, DA	1
Thrivikraman, KV	1
Nemeroff, CB	1
Owens, MJ	1
Siepmann, M	1
Heine, B	1
Kluge, A	1
Ziemssen, T	1
Mück-Weymann, M	1
Kirch, W	1
Jerome, L	1
Ibatov, AD	1
Marchesi, C	1
De Panfilis, C	1
Cantoni, A	1
Giannelli, MR	1
Maggini, C	1
Vohra, R	1
Cantrell, FL	1
Williams, SR	1
Bonomo, JB	1
Butler, AS	1
Lindsell, CJ	1
Venkat, A	1
Male, CG	2
Lim, YT	1
Male, M	1
Stewart, JM	1
Gibbs, JM	1
Saletu, B	1
Grünberger, J	1
Linzmayer, L	1
Stadler, R	1
Howe, JG	1
Rubin, J	1
Schweggmann, I	1
Uys, P	1
Rickels, K	3
Mundeleer, P	1
Bradshaw, EG	1
Ali, AA	1
Mulley, BA	1
Rye, RM	1
Lapierre, YD	1
de Figueiredo, R	1
Franchini, A	1
Martinho, A	1
Hindmarch, I	1
Fischer-Cornelssen, KA	1
Ong, BY	1
Pickering, BG	1
Palahniuk, RJ	1
Cumming, M	1
Oswald, I	2
French, C	1
Adam, K	2
Gilham, J	1
File, SE	4
Bond, AJ	1
Lister, RG	3
Mizuguchi, T	1
Tanaka, T	1
Higuchi, S	1
Burton, AJ	1
Gale, GD	3
Galloon, S	3
Porter, WR	1
Houghton, DJ	1
Oblowitz, H	1
Robins, AH	1
Blitt, CD	1
Ulsamer, B	1
Doenicke, A	2
Ott, H	1
Suttmann, H	1
Johnson, HD	1
Harris, PG	1
Bouyer, JJ	1
Rougeul, A	1
Russell, WJ	1
Melo de Paula, AJ	1
Fitzal, S	1
Groll-Knapp, E	1
Länger, W	1
Riegler, R	1
Walsh, JK	1
Schweitzer, PK	1
Parwatikar, S	1
Ohayon, MM	1
Caulet, M	1
Bailine, SH	1
Safferman, A	1
Vital-Herne, J	1
Bernstein, S	1
Deppe, SA	1
Sipperly, ME	1
Sargent, AI	1
Kuwik, RJ	1
Thompson, DR	1
Gianoutsos, MP	1
Hunter-Smith, D	1
Smith, JG	1
Hogan, D	1
McEwan, L	1
Charrier, D	1
Dangoumau, L	1
Puech, AJ	1
Hamon, M	1
Thiébot, MH	1
Bhattacharya, SK	3
Chakrabarti, A	2
Sandler, M	2
Glover, V	2
Northoff, G	1
Wenke, J	1
Demisch, L	1
Eckert, J	1
Gille, B	1
Pflug, B	1
Patterson, DR	1
Ptacek, JT	1
Carrougher, GJ	1
Sharar, SR	1
Romach, MK	1
Kaplan, HL	1
Busto, UE	1
Somer, G	1
Sellers, EM	2
Addis, A	1
Dolovich, LR	1
Einarson, TR	1
Koren, G	1
Di Lazzaro, V	1
Oliviero, A	1
Meglio, M	1
Cioni, B	1
Tamburrini, G	1
Tonali, P	1
Rothwell, JC	1
Kumar, V	1
Singh, RK	1
Jaiswal, AK	1
Acharya, SB	1
Kopp, M	1
Holzner, B	1
Brugger, A	1
Nachbaur, D	1
Wolanskyj, AP	1
Schroeder, G	1
Wilson, PR	1
Habermann, TM	1
Inwards, DJ	1
Witzig, TE	1
Noerr, B	1
Malcolm, R	1
Myrick, H	1
Roberts, J	1
Wang, W	1
Anton, RF	1
Bellan, L	1
Gooi, A	1
Rehsia, S	1
Maneksha, S	1
Harry, TV	1
Conner, JT	2
Parson, N	1
Katz, RL	2
Wapner, S	1
Bellville, JW	2
Valarino, F	1
Perez-Lopez, R	1
Kasich, AM	1
Furtado, JD	1
Battelli, T	1
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Richards, DJ	2
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Resistance Under the Microscope; a Randomized Placebo Controlled Parallel Group Design[NCT01441843]	Phase 4	400 participants (Actual)	Interventional	2010-10-31	Completed
Double-blind, Randomized, Placebo-controlled Study on the Effect of Multimodal Analgesia on Pain With Insertion of Levonorgestrel-releasing Intrauterine System[NCT02799641]		61 participants (Actual)	Interventional	2016-07-31	Completed
An Evaluation of Hydrocodone/Acetaminophen for Pain Control in First Trimester Surgical Abortion[NCT01330459]	Phase 4	121 participants (Actual)	Interventional	2011-02-28	Completed
Oral Sedation During Cervical Dilator Placement: A Randomized Controlled Trial[NCT03202550]	Phase 4	27 participants (Actual)	Interventional	2017-06-28	Completed
An Evaluation of the Paracervical Block for Pain Control in First Trimester Surgical Abortion[NCT01094366]	Phase 4	121 participants (Actual)	Interventional	2010-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"The Quality of Recovery Score - 40 (QoR-40), a 40-item scale, is used to assess the quality of recovery.~Each item is rated on a five-point Likert scale (1-5), and the QoR-40 score is calculated as the sum of the scores on these items. Minimal possible score = 40, maximal possible score = 200. A higher score indicates a higher level of quality of recovery." (NCT01441843)
Timeframe: Baseline; first postoperative working day; seventh postoperative day.

Need for Additional Intraoperative and/or Postoperative Pain Medication

Intervention	scores on a scale (Mean)
	Seventh postoperative day	First postoperative working day	Baseline
Lorazepam	172.8	174.5	177.2
NaCl 0.9%	176.3	176.4	180.4

To assess need for additional intraoperative and/or postoperative pain medication (NCT01330459)
Timeframe: 30 minutes after completion of the procedure (which started 45-90 minutes after study drug administration)

Patient Perception of Pain

Intervention	Participants (Count of Participants)
Hydrocodone/Acetaminophen	0
Placebo	0

To determine whether HC/APAP, given in addition to a standard regimen of ibuprofen, lorazepam, and PCB, affects patient pain perception at the time of uterine aspiration, as measured by distance (mm) from the left of the 100 mm visual analog scale (VAS). The number 0 indicates no pain, and 100 indicates worst pain imaginable. (NCT01330459)
Timeframe: At time of uterine aspiration (baseline)

Patient Perception of Pain During Cervical Dilation

Intervention	mm (Mean)
Hydrocodone/Acetaminophen	65.7
Placebo	63.1

Distance (mm) from the left of the 100 mm VAS scale (VAS anchors: 0 = none, 100 mm = worst imaginable) recorded after cervical dilation (NCT01330459)
Timeframe: During procedure (approximately 45-90 min after hydrocodone/acetaminophen or placebo, and within 5 minutes of procedure starting)

Postoperative Nausea

Intervention	mm (Mean)
Hydrocodone/Acetaminophen	47.2
Placebo	43.9

To assess whether HC/APAP is associated with nausea, measured on the 100 mm VAS, recorded 30 minutes postoperatively. VAS anchors: 0 indicates no pain, and 100 indicates worst pain imaginable. (NCT01330459)
Timeframe: 30 minutes after completion of the procedure (which started 45-90 minutes after study drug administration)

Satisfaction With Pain Control

Intervention	mm (Mean)
Hydrocodone/Acetaminophen	19.4
Placebo	11.4

Distance (mm) from the left of the 100 mm VAS (VAS anchors: 0 = unsatisfied, 100 mm = very satisfied) recorded 30 minutes after completion of the procedure. (NCT01330459)
Timeframe: 30 minutes after completion of the procedure (which started 45-90 minutes after study drug administration)

Baseline Pain Score Before Drugs Were Administered

Intervention	mm (Mean)
Hydrocodone/Acetaminophen	74.8
Placebo	67.3

Compare pain scores on a 100 mm visual analog scale (VAS) (anchors 0=no pain; 100=worst pain ever) (NCT03202550)
Timeframe: pain score given prior to administration of study drugs, up to 1 minute

Cervical Dilator Placement Pain as Assessed by VAS on a Tablet Device

Intervention	units on a scale (Median)
Placebo Arm	3
Active Drug Arm: Lorazepam and Oxycodone	2

Compare pain scores on a 100 mm visual analog scale (VAS) (anchors 0=no pain; 100=worst pain ever) (NCT03202550)
Timeframe: Immediately after the last dilator is placed, up to 1 minute

Number of Participants With Desired Number of Dilators Inserted

Intervention	units on a scale (Median)
Placebo Arm	55
Active Drug Arm: Lorazepam and Oxycodone	44

Assess whether desired number of dilators was not able to be successfully inserted, comparing 2 arms. (NCT03202550)
Timeframe: After speculum removed, up to 30 minutes

Pain Score 15 Minutes After Last Dilator Placed

Intervention	Participants (Count of Participants)
Placebo Arm	13
Active Drug Arm: Lorazepam and Oxycodone	10

Compare pain scores on a 100 mm visual analog scale (VAS) (anchors 0=no pain; 100=worst pain ever). This was to be assessed at 15 minutes after last dilator is placed. Some participants had this assessment done up to 45 minutes after last dilator was placed because it could not be done at 15 minutes (some were being attended to by a nurse at the 15 minutes mark). (NCT03202550)
Timeframe: Assessed up to 45 minutes after last dilator placed

Pain Score After First Dilator Placement

Intervention	units on a scale (Median)
Placebo Arm	29
Active Drug Arm: Lorazepam and Oxycodone	13

Compare pain scores on a 100 mm visual analog scale (VAS) (anchors 0=no pain; 100=worst pain ever) (NCT03202550)
Timeframe: pain score given immediately after first dilator placed, up to 1 minute

Pain Score After Speculum Placement

Intervention	units on a scale (Median)
Placebo Arm	50
Active Drug Arm: Lorazepam and Oxycodone	9

Compare pain scores on a 100 mm visual analog scale (VAS) (anchors 0=no pain; 100=worst pain ever) (NCT03202550)
Timeframe: pain score given at time of speculum placement, up to 1 minute

Pain Score at Tenaculum Placement

Intervention	units on a scale (Median)
Placebo Arm	20
Active Drug Arm: Lorazepam and Oxycodone	11

Compare pain scores on a 100 mm visual analog scale (VAS) (anchors 0=no pain; 100=worst pain ever) (NCT03202550)
Timeframe: Immediately scored at time of tenacula placement, up to 1 minute

Pain Score Before Speculum Placement

Intervention	units on a scale (Median)
Placebo Arm	31
Active Drug Arm: Lorazepam and Oxycodone	50

Compare pain scores on a 100 mm visual analog scale (VAS) (anchors 0=no pain; 100=worst pain ever) (NCT03202550)
Timeframe: pain score given before specula placed, up to 1 minute

Pain Score During Paracervical Block

Intervention	units on a scale (Median)
Placebo Arm	1
Active Drug Arm: Lorazepam and Oxycodone	1

Compare pain scores on a 100 mm visual analog scale (VAS) (anchors 0=no pain; 100=worst pain ever) (NCT03202550)
Timeframe: pain score given at time of paracervical block administration, up to 1 minute

Article	Year
Efficacy and Safety of Anxiolytics in Mohs Micrographic Surgery: A Randomized, Double-Blinded, Placebo-Controlled Trial. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2023, 11-01, Volume: 49, Issue:11 Topics: Alprazolam; Anti-Anxiety Agents; Anxiety; Diazepam; Double-Blind Method; Gabapentin; Humans; Lorazep	2023
Amygdala Lesions Reduce Anxiety-like Behavior in a Human Benzodiazepine-Sensitive Approach-Avoidance Conflict Test. Biological psychiatry, 2017, Oct-01, Volume: 82, Issue:7 Topics: Adult; Amygdala; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Brain Injuries; Case-Control Stud	2017
An Easy and Reliable Way to Prevent Electrocardiographic Deteriorations of Patients Undergoing Off-Pump Coronary Artery Bypass Surgery: Preoperative Anxiolytic Treatment. Brazilian journal of cardiovascular surgery, 2019, 06-01, Volume: 34, Issue:3 Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Anxiety; Arrhythmias, Cardiac; Coronary Artery Bypass,	2019
Lorazepam does not improve the quality of recovery in day-case surgery patients: a randomised placebo-controlled clinical trial. European journal of anaesthesiology, 2013, Volume: 30, Issue:12 Topics: Adult; Aggression; Ambulatory Surgical Procedures; Anti-Anxiety Agents; Anxiety; Double-Blind Method	2013
Implication of UGT2B15 Genotype Polymorphism on Postoperative Anxiety Levels in Patients Receiving Lorazepam Premedication. Anesthesia and analgesia, 2016, Volume: 123, Issue:5 Topics: Adult; Ambulatory Surgical Procedures; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Ge	2016
Effects of lorazepam on brain activity pattern during an anxiety symptom provocation challenge. Journal of psychopharmacology (Oxford, England), 2010, Volume: 24, Issue:5 Topics: Adolescent; Adult; Anti-Anxiety Agents; Anxiety; Attention; Brain; Double-Blind Method; Drug Evaluat	2010
Effects of Lorazepam and citalopram on human defensive reactions: ethopharmacological differentiation of fear and anxiety. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Oct-07, Volume: 29, Issue:40 Topics: Adult; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Anxiety; Avoidance Learning; C	2009
One milligram of lorazepam does not decrease anxiety induced by CCK-4 in healthy volunteers: investigation of neural correlates with BOLD MRI. Journal of psychopharmacology (Oxford, England), 2011, Volume: 25, Issue:1 Topics: Adult; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Attention; Cerebral Cortex; Cross-Over Studi	2011
Dyspnoea associated with anxiety--symptomatic therapy with opioids in combination with lorazepam and its effect on ventilation in palliative care patients. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2011, Volume: 19, Issue:12 Topics: Aged; Analgesics, Opioid; Anxiety; Drug Interactions; Dyspnea; Female; Germany; Humans; Hypnotics an	2011
Preliminary evidence of anxiolytic effects of the CRF(1) receptor antagonist R317573 in the 7.5% CO(2) proof-of-concept experimental model of human anxiety. Journal of psychopharmacology (Oxford, England), 2011, Volume: 25, Issue:9 Topics: Administration, Inhalation; Adult; Anti-Anxiety Agents; Anxiety; Carbon Dioxide; Double-Blind Method	2011
Prophylactic analgesia before percutaneous liver biopsy: a clinical comparative study. European journal of gastroenterology & hepatology, 2011, Volume: 23, Issue:9 Topics: Adult; Analgesia; Analgesics, Opioid; Anti-Anxiety Agents; Anxiety; Biopsy, Needle; Diazepam; Female	2011
Oxytocin interference in the effects induced by inhalation of 7.5% CO(2) in healthy volunteers. Human psychopharmacology, 2012, Volume: 27, Issue:4 Topics: Administration, Inhalation; Administration, Intranasal; Adult; Anti-Anxiety Agents; Anxiety; Blood P	2012
The effect of a clinically effective and non-effective dose of lorazepam on 7.5% CO₂-induced anxiety. Human psychopharmacology, 2012, Volume: 27, Issue:6 Topics: Administration, Inhalation; Adult; Anti-Anxiety Agents; Anxiety; Asphyxia; Carbon Dioxide; Cross-Ove	2012
The effect of lorazepam on pain and anxiety in abortion. Contraception, 2003, Volume: 67, Issue:3 Topics: Abortion, Induced; Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Humans; Lorazep	2003
The effect of lorazepam on pain and anxiety in abortion. Contraception, 2003, Volume: 67, Issue:3 Topics: Abortion, Induced; Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Humans; Lorazep	2003
The effect of lorazepam on pain and anxiety in abortion. Contraception, 2003, Volume: 67, Issue:3 Topics: Abortion, Induced; Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Humans; Lorazep	2003
The effect of lorazepam on pain and anxiety in abortion. Contraception, 2003, Volume: 67, Issue:3 Topics: Abortion, Induced; Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Humans; Lorazep	2003
The effect of lorazepam on pain and anxiety in abortion. Contraception, 2003, Volume: 67, Issue:3 Topics: Abortion, Induced; Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Humans; Lorazep	2003
The effect of lorazepam on pain and anxiety in abortion. Contraception, 2003, Volume: 67, Issue:3 Topics: Abortion, Induced; Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Humans; Lorazep	2003
The effect of lorazepam on pain and anxiety in abortion. Contraception, 2003, Volume: 67, Issue:3 Topics: Abortion, Induced; Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Humans; Lorazep	2003
The effect of lorazepam on pain and anxiety in abortion. Contraception, 2003, Volume: 67, Issue:3 Topics: Abortion, Induced; Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Humans; Lorazep	2003
The effect of lorazepam on pain and anxiety in abortion. Contraception, 2003, Volume: 67, Issue:3 Topics: Abortion, Induced; Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Humans; Lorazep	2003
The effect of lorazepam on pain and anxiety in abortion. Contraception, 2003, Volume: 67, Issue:3 Topics: Abortion, Induced; Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Humans; Lorazep	2003
The effect of lorazepam on pain and anxiety in abortion. Contraception, 2003, Volume: 67, Issue:3 Topics: Abortion, Induced; Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Humans; Lorazep	2003
The effect of lorazepam on pain and anxiety in abortion. Contraception, 2003, Volume: 67, Issue:3 Topics: Abortion, Induced; Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Humans; Lorazep	2003
The effect of lorazepam on pain and anxiety in abortion. Contraception, 2003, Volume: 67, Issue:3 Topics: Abortion, Induced; Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Humans; Lorazep	2003
The effect of lorazepam on pain and anxiety in abortion. Contraception, 2003, Volume: 67, Issue:3 Topics: Abortion, Induced; Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Humans; Lorazep	2003
The effect of lorazepam on pain and anxiety in abortion. Contraception, 2003, Volume: 67, Issue:3 Topics: Abortion, Induced; Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Humans; Lorazep	2003
The effect of lorazepam on pain and anxiety in abortion. Contraception, 2003, Volume: 67, Issue:3 Topics: Abortion, Induced; Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Humans; Lorazep	2003
The use of a short-acting benzodiazepine to reduce the risk of syncopal episodes during upright stereotactic breast biopsy. Clinical radiology, 2005, Volume: 60, Issue:3 Topics: Administration, Sublingual; Anti-Anxiety Agents; Anxiety; Biopsy, Fine-Needle; Breast Diseases; Fema	2005
Effects of lorazepam on fear-potentiated startle responses in man. Journal of psychopharmacology (Oxford, England), 2005, Volume: 19, Issue:3 Topics: Acoustic Stimulation; Adolescent; Adult; Anxiety; Blinking; Cross-Over Studies; Dose-Response Relati	2005
Dissociation between perceptual processing and priming in long-term lorazepam users. The international journal of neuropsychopharmacology, 2006, Volume: 9, Issue:6 Topics: Adult; Aged; Anti-Anxiety Agents; Anxiety; Cues; Female; Humans; Hypnotics and Sedatives; Lorazepam;	2006
Efficacy of etifoxine compared to lorazepam monotherapy in the treatment of patients with adjustment disorders with anxiety: a double-blind controlled study in general practice. Human psychopharmacology, 2006, Volume: 21, Issue:3 Topics: Adjustment Disorders; Adolescent; Adult; Aged; Anti-Anxiety Agents; Anxiety; Confidence Intervals; D	2006
The effects of lorazepam on skin conductance responses to aversive stimuli in healthy subjects. Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2007, Volume: 17, Issue:3 Topics: Acoustic Stimulation; Adult; Affect; Anti-Anxiety Agents; Anxiety; Cross-Over Studies; Double-Blind	2007
Effect of pharmacological treatment on temperament and character in panic disorder. Psychiatry research, 2008, Mar-15, Volume: 158, Issue:2 Topics: Adult; Anxiety; Character; Citalopram; Female; Follow-Up Studies; GABA Modulators; Humans; Lorazepam	2008
Comparison of three benzodiazepines for oral premedication in minor gynaecological surgery. British journal of anaesthesia, 1980, Volume: 52, Issue:4 Topics: Adolescent; Adult; Anti-Anxiety Agents; Anxiety; Clinical Trials as Topic; Diazepam; Dilatation and	1980
Lorazepam as a premedicant in dental surgery. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1980, Jul-19, Volume: 58, Issue:3 Topics: Adolescent; Adult; Anesthesia, General; Anti-Anxiety Agents; Anxiety; Clinical Trials as Topic; Dent	1980
Differences in the effect of two benzodiazepines in the treatment of anxious outpatients. International pharmacopsychiatry, 1981, Volume: 16, Issue:1 Topics: Adult; Ambulatory Care; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Benzodiazepinones; Clinical T	1981
Multicenter trials and complementary studies of cloxazolam, a new anxiolytic drug. Arzneimittel-Forschung, 1981, Volume: 31, Issue:10 Topics: Adult; Aged; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Benzodiazepinones; Clinical Trials as To	1981
Benzodiazepine hypnotics remain effective for 24 weeks. British medical journal (Clinical research ed.), 1982, Mar-20, Volume: 284, Issue:6319 Topics: Adult; Aged; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Clinical Trials as Topic; Double-Blind M	1982
Interaction between effects of caffeine and lorazepam in performance tests and self-ratings. Journal of clinical psychopharmacology, 1982, Volume: 2, Issue:2 Topics: Adult; Anti-Anxiety Agents; Anxiety; Caffeine; Drug Interactions; Emotions; Female; Flicker Fusion;	1982
Recalled apprehension after premedication with lorazepam. Anaesthesia, 1982, Volume: 37, Issue:10 Topics: Adult; Anti-Anxiety Agents; Anxiety; Diazepam; Female; Humans; Lorazepam; Memory; Mental Recall; Opi	1982
Performance impairment and increased anxiety resulting from the combination of alcohol and lorazepam. Journal of clinical psychopharmacology, 1983, Volume: 3, Issue:2 Topics: Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Drug Interactions; Ethanol; Female; Humans	1983
Sublingual lorazepam: a better premedication? British journal of anaesthesia, 1983, Volume: 55, Issue:8 Topics: Administration, Oral; Adult; Anti-Anxiety Agents; Anxiety; Arousal; Female; Humans; Injections, Intr	1983
Use of lorazepam as a premedicant for caesarean section. An evaluation of its effects on the mother and the neonate. British journal of anaesthesia, 1983, Volume: 55, Issue:8 Topics: Anti-Anxiety Agents; Anxiety; Apgar Score; Blood Gas Analysis; Body Temperature; Cesarean Section; F	1983
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The role of general practitioner research groups in the study of benzodiazepines. L'Encephale, 1983, Volume: 9, Issue:4 Suppl 2 Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Anxiety; Clinical Trials as Topic; Clorazepate Dipotas	1983
Lorazepam as a premedicant for regional anaesthesia. Anaesthesia, 1983, Volume: 38, Issue:11 Topics: Aged; Anesthesia, Spinal; Anxiety; Clinical Trials as Topic; Double-Blind Method; Humans; Lorazepam;	1983
Comparative study of lormetazepam and flurazepam in the treatment of insomnia. Clinical therapeutics, 1984, Volume: 6, Issue:4 Topics: Adult; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Clinical Trials as Topic; Dose-Response Relati	1984
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Lorazepam in gastrointestinal disorders with anxiety overlay. Psychosomatics, 1976, Volume: 17, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Anxiety; Clinical Trials as Topic; Drug Evaluation; Fe	1976
Lorazepam and diazepam in anxious outpatients. A controlled study. International pharmacopsychiatry, 1976, Volume: 11, Issue:2 Topics: Adult; Anti-Anxiety Agents; Anxiety; Clinical Trials as Topic; Diazepam; Female; Humans; Lorazepam;	1976
[Lorazepam (Temesta) versus bromazepam (Lexotanil). A controlled cross-study]. MMW, Munchener medizinische Wochenschrift, 1976, Oct-08, Volume: 118, Issue:41 Topics: Adult; Anti-Anxiety Agents; Anxiety; Bromazepam; Clinical Trials as Topic; Drug Evaluation; Female;	1976
A comparison of high- and low-dose lorazepam with amylobarbitone in patients with anxiety states. The American journal of psychiatry, 1977, Volume: 134, Issue:1 Topics: Adolescent; Adult; Aged; Amobarbital; Anti-Anxiety Agents; Anxiety; Clinical Trials as Topic; Drug E	1977
A multiclinic double-blind trial of the anxiolytic properties of lorazepam in psychiatric outpatient practice [proceedings]. Psychopharmacology bulletin, 1977, Volume: 13, Issue:2 Topics: Anti-Anxiety Agents; Anxiety; Clinical Trials as Topic; Drug Evaluation; Humans; Lorazepam; Psychiat	1977
Comparison of lorazepam and diazepam as premedicants. British journal of anaesthesia, 1977, Volume: 49, Issue:12 Topics: Adult; Amnesia; Anti-Anxiety Agents; Anxiety; Clinical Trials as Topic; Diazepam; Double-Blind Metho	1977
A study in the management of anxiety with lorazepam. Journal of clinical pharmacology, 1978, Volume: 18, Issue:4 Topics: Adult; Anti-Anxiety Agents; Anxiety; Clinical Trials as Topic; Female; Humans; Lorazepam; Male; Midd	1978
Lorazepam, hyoscine and atropine as i.v. surgical premedicants. British journal of anaesthesia, 1978, Volume: 50, Issue:5 Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Anxiety; Atropine; Clinical Trials as Topic; Double-Bl	1978
Comparative study of two long-acting tranquillizers for oral premedication. British journal of anaesthesia, 1978, Volume: 50, Issue:10 Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Anxiety Agents; Anxiety; Clinical Trials as Topi	1978
The effect of lorazepam on hypertension-associated anxiety: a double-blind study. The Journal of clinical psychiatry, 1978, Volume: 39, Issue:10 Pt 2 Topics: Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Drug Evaluation; Female; Humans; Hypertens	1978
A clinical assessment of lorazepam in the treatment of anxiety associated with gastrointestinal symptomatology. The Journal of clinical psychiatry, 1978, Volume: 39, Issue:10 Pt 2 Topics: Administration, Oral; Adolescent; Adult; Aged; Ambulatory Care; Anti-Anxiety Agents; Anxiety; Double	1978
Lorazepam in anxiety associated with chronic enteritis and ulcerative colitis. The Journal of clinical psychiatry, 1978, Volume: 39, Issue:10 Pt 2 Topics: Administration, Oral; Adolescent; Adult; Anti-Anxiety Agents; Anxiety; Colitis, Ulcerative; Double-B	1978
Lorazepam, a new benzodiazepine derivative, in the treatment of anxiety: a double-blind clinical evaluation. The American journal of psychiatry, 1979, Volume: 136, Issue:2 Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Anxiety; Clinical Trials as Topic; Double-Blind Method	1979
Multivariate symptom analysis related to response to lorazepam treatment. Current medical research and opinion, 1979, Volume: 6, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Anxiety; Clinical Trials as Topic; Female; Humans; Lor	1979
The use of lorazepam in cardiac bypass surgery: a comparative study. Current medical research and opinion, 1979, Volume: 6, Issue:4 Topics: Adolescent; Adult; Aged; Anesthesia; Anti-Anxiety Agents; Anxiety; Cardiopulmonary Bypass; Child; Cl	1979
The use of lorazepam as a soporific and for premedication. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1975, Aug-09, Volume: 49, Issue:34 Topics: Adolescent; Adult; Anti-Anxiety Agents; Anxiety; Blood Pressure; Female; Heart Rate; Humans; Lorazep	1975
Therapy of anxiety in patients with rheumatic disease: crossover double-blind study comparing lorazepam with placebo. Psychosomatics, 1975, Volume: 16, Issue:3 Topics: Adult; Anti-Anxiety Agents; Anxiety; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Lora	1975
GI illness: treatment of the anxiety component. Psychosomatics, 1977, Volume: 18, Issue:4 Topics: Adolescent; Adult; Aged; Anxiety; Clinical Trials as Topic; Double-Blind Method; Female; Gastrointes	1977
The measurement of anxiety in the pre-surgical patient. British journal of anaesthesia, 1977, Volume: 49, Issue:6 Topics: Anxiety; Female; Humans; Lorazepam; Papaverine; Preanesthetic Medication; Preoperative Care; Psychia	1977
A comparative study of alpidem, a nonbenzodiazepine, and lorazepam in patients with nonpsychotic anxiety. Psychopharmacology bulletin, 1991, Volume: 27, Issue:1 Topics: Adult; Anti-Anxiety Agents; Anxiety; Female; Humans; Imidazoles; Lorazepam; Male; Middle Aged; Psych	1991
Dose-dependent effects of intravenous lorazepam on cardiovascular activity, plasma catecholamines and psychological function during rest and mental stress. Psychopharmacology, 1991, Volume: 105, Issue:1 Topics: Adult; Affect; Anxiety; Catecholamines; Dose-Response Relationship, Drug; Double-Blind Method; Elect	1991
[Benzodiazepine withdrawal syndrome. Problems of differential diagnosis against depression, panic attacks and generalized anxiety]. La Clinica terapeutica, 1991, May-15, Volume: 137, Issue:3 Topics: Anxiety; Benzodiazepines; Depression; Diagnosis, Differential; Double-Blind Method; Humans; Lorazepa	1991
Models of memory dysfunction? A comparison of the effects of scopolamine and lorazepam on memory, psychomotor performance and mood. Psychopharmacology, 1991, Volume: 103, Issue:1 Topics: Adult; Affect; Anxiety; Double-Blind Method; Female; Flicker Fusion; Humans; Hypnotics and Sedatives	1991
Comparison of various physiologic and psychomotor parameters in patients sedated with intravenous lorazepam, diazepam, or midazolam during oral surgery. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1991, Volume: 49, Issue:7 Topics: Adolescent; Adult; Analysis of Variance; Anesthesia, Dental; Anesthesia, Local; Anxiety; Blood Press	1991
Double-blind placebo cross-over study of long-acting (chlordesmethyldiazepam) versus short-acting (lorazepam) benzodiazepines in generalized anxiety disorders. International journal of clinical pharmacology research, 1989, Volume: 9, Issue:3 Topics: Adult; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Diazepam; Double-Blind Method; Female; Humans;	1989
A comparative study of suriclone, lorazepam and placebo in anxiety disorder. Pharmacopsychiatry, 1989, Volume: 22, Issue:6 Topics: Adult; Anti-Anxiety Agents; Anxiety; Double-Blind Method; Female; Humans; Lorazepam; Male; Middle Ag	1989
Can a rapidly-eliminated hypnotic cause daytime anxiety? Pharmacopsychiatry, 1989, Volume: 22, Issue:3 Topics: Adult; Aged; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Body Weight; Dreams; Female; Humans; Hyp	1989
Beta-blockers and psychic stress: a double-blind, placebo-controlled study of bopindolol vs lorazepam and butalbital in surgical patients. International journal of clinical pharmacology, therapy, and toxicology, 1985, Volume: 23, Issue:9 Topics: Adrenergic beta-Antagonists; Adult; Aged; Anxiety; Barbiturates; Clinical Trials as Topic; Double-Bl	1985
Changes in noradrenaline plasma levels and behavioural responses induced by benzodiazepine agonists with the benzodiazepine antagonist Ro 15-1788. Psychopharmacology, 1986, Volume: 90, Issue:3 Topics: Adult; Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Blood Pressure; Double-Blind Method;	1986
[Effect and side effects of oral morphine, lormetazepam and placebos as premedication]. Anasthesie, Intensivtherapie, Notfallmedizin, 1987, Volume: 22, Issue:3 Topics: Administration, Oral; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Clinical Trials as Topic; Depre	1987
A new lormetazepam galenical formulation for sublingual premedication. Acta anaesthesiologica Belgica, 1988, Volume: 39, Issue:4 Topics: Administration, Sublingual; Adult; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Double-Blind Metho	1988
A double-blind comparison between nitrazepam, lorazepam, lormetazepam and placebo as preoperative night sedatives. European journal of anaesthesiology, 1988, Volume: 5, Issue:6 Topics: Adult; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method;	1988
Withdrawal reaction after long-term therapeutic use of benzodiazepines. The New England journal of medicine, 1986, Oct-02, Volume: 315, Issue:14 Topics: Adolescent; Adult; Aged; Anxiety; Benzodiazepines; Diazepam; Double-Blind Method; Female; Flurazepam	1986
Differential effects of oxazepam and lorazepam on aggressive responding. Psychopharmacology, 1988, Volume: 95, Issue:3 Topics: Adult; Aggression; Anxiety; Emotions; Female; Humans; Lorazepam; Male; Middle Aged; Oxazepam; Reacti	1988
Efficacy of lorazepam oral fast dissolving drug formulation (FDDF) in anesthesia premedication in adults: a double-blind placebo controlled comparison. Acta anaesthesiologica Belgica, 1988, Volume: 39, Issue:2 Topics: Absorption; Administration, Oral; Adult; Aged; Anxiety; Double-Blind Method; Female; Humans; Lorazep	1988
Lormetazepam or triazolam as night sedation before surgery. The British journal of clinical practice, 1986, Volume: 40, Issue:7 Topics: Adult; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Female; Humans; Lorazepam; Premedication; Slee	1986
Triazolam premedication. A comparison with lorazepam and placebo in gynaecological patients. Anaesthesia, 1986, Volume: 41, Issue:7 Topics: Adolescent; Adult; Anesthesia Recovery Period; Anxiety; Dizziness; Double-Blind Method; Drug Evaluat	1986
A comparison of the effects of lorazepam with those of propranolol on experimentally-induced anxiety and performance. British journal of clinical pharmacology, 1985, Volume: 19, Issue:4 Topics: Adult; Anxiety; Clinical Trials as Topic; Double-Blind Method; Emotions; Female; Humans; Lorazepam;	1985
Indications and contraindications for chronic anxiolytic treatment: is there tolerance to the anxiolytic effect? Advances in biochemical psychopharmacology, 1985, Volume: 40 Topics: Anxiety; Chronic Disease; Clinical Trials as Topic; Clorazepate Dipotassium; Diazepam; Double-Blind	1985
Consecutive dose-finding trials adding lorazepam to the combination of metoclopramide plus dexamethasone: improved subjective effectiveness over the combination of diphenhydramine plus metoclopramide plus dexamethasone. Cancer treatment reports, 1985, Volume: 69, Issue:11 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Anxiety; Cisplatin; Clinical Trials as	1985

Article	Year
A selective small molecule NOP (ORL-1 receptor) partial agonist for the treatment of anxiety. Bioorganic & medicinal chemistry letters, 2015, Feb-01, Volume: 25, Issue:3 Topics: Animals; Anxiety; Disease Models, Animal; Motor Activity; Nociceptin; Nociceptin Receptor; Opioid Pe	2015
Escitalopram and lorazepam differentially affect nesting and open field behaviour in deer mice exposed to an anxiogenic environment. Neuroscience research, 2022, Volume: 177 Topics: Animals; Anxiety; Escitalopram; Humans; Lorazepam; Mice; Peromyscus	2022
Mental health and drug use in college students: Should we take action? Journal of affective disorders, 2023, 10-01, Volume: 338 Topics: Anxiety; COVID-19; Depression; Humans; Lorazepam; Mental Health; Students; Substance-Related Disorde	2023
Anxiolytics cause anxiety in pancreatic cancer. Trends in cancer, 2023, Volume: 9, Issue:11 Topics: Anti-Anxiety Agents; Anxiety; Benzodiazepines; Humans; Lorazepam; Pancreatic Neoplasms; Receptors, G	2023
Serotonin syndrome from sertraline monotherapy. The American journal of emergency medicine, 2020, Volume: 38, Issue:8 Topics: Adult; Anti-Anxiety Agents; Anxiety; Humans; Lorazepam; Male; Selective Serotonin Reuptake Inhibitor	2020
An integrative analysis of 5HTT-mediated mechanism of hyperactivity to non-threatening voices. Communications biology, 2020, 03-10, Volume: 3, Issue:1 Topics: Acoustic Stimulation; Adult; Anti-Anxiety Agents; Anxiety; Arousal; Brain; Cross-Over Studies; Doubl	2020
Informal Caregivers' Administration of Hospice Prescribed Lorazepam to Homecare Patients With Anxiety. The American journal of hospice & palliative care, 2021, Volume: 38, Issue:9 Topics: Anxiety; Caregivers; Home Care Services; Hospice Care; Hospices; Humans; Lorazepam; Retrospective St	2021
Intranasal Lorazepam for Treatment of Severe Agitation in a Pediatric Behavioral Health Patient in the Emergency Department. Annals of emergency medicine, 2020, Volume: 75, Issue:1 Topics: Administration, Intranasal; Anxiety; Attention Deficit and Disruptive Behavior Disorders; Child; Dos	2020
Quetiapine reduces irritability and risk of suicide in patients with agitated depression. The Tokai journal of experimental and clinical medicine, 2013, Jul-20, Volume: 38, Issue:2 Topics: Antipsychotic Agents; Anxiety; Depression; Dibenzothiazepines; Drug Therapy, Combination; Female; Hu	2013
Preoperative evaluation and preparation by anaesthesiologists only, please! European journal of anaesthesiology, 2013, Volume: 30, Issue:12 Topics: Ambulatory Surgical Procedures; Anti-Anxiety Agents; Anxiety; Breast Neoplasms; Female; Humans; Lora	2013
Adverse performance effects of acute lorazepam administration in elderly long-term users: pharmacokinetic and clinical predictors. Progress in neuro-psychopharmacology & biological psychiatry, 2015, Jan-02, Volume: 56 Topics: Aged; Aged, 80 and over; Anti-Anxiety Agents; Anxiety; Cross-Over Studies; Double-Blind Method; Emot	2015
Effects of lorazepam and WAY-200070 in larval zebrafish light/dark choice test. Neuropharmacology, 2015, Volume: 95 Topics: Animals; Anti-Anxiety Agents; Anxiety; Boron Compounds; Choice Behavior; Diazepam; Estradiol; Estrog	2015
GABAergic modulation with classical benzodiazepines prevent stress-induced neuro-immune dysregulation and behavioral alterations. Brain, behavior, and immunity, 2016, Volume: 51 Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bone Marrow; Brain; CD11b Antigen; Clonazep	2016
Old dog, new tricks: treating co-occurring anxiety and alcohol use disorders. The American journal of drug and alcohol abuse, 2016, Volume: 42, Issue:5 Topics: Alcohol-Related Disorders; Alcoholism; Anxiety; Anxiety Disorders; Disulfiram; Humans; Lorazepam; Pi	2016
Look again at psychedelic drugs. Nursing standard (Royal College of Nursing (Great Britain) : 1987), 2016, Jun-29, Volume: 30, Issue:44 Topics: Anxiety; Delirium; Depression; Diazepam; Hallucinogens; Haloperidol; Humans; Lorazepam; Midazolam; P	2016
Dual cocaine and methamphetamine cardiovascular toxicity: rapid resolution with labetalol. The American journal of emergency medicine, 2017, Volume: 35, Issue:3 Topics: Administration, Intravenous; Adrenergic beta-Antagonists; Amphetamine-Related Disorders; Anti-Anxiet	2017
Black Hairy Tongue Associated With Lorazepam Treatment of a Male Smoker With Major Depression. Journal of clinical psychopharmacology, 2017, Volume: 37, Issue:2 Topics: Anti-Anxiety Agents; Anxiety; Depressive Disorder, Major; Humans; Lorazepam; Male; Middle Aged; Tong	2017
Evaluation of anxiolytic-like effects of some short-acting benzodiazepine hypnotics in mice. Journal of pharmacological sciences, 2008, Volume: 107, Issue:3 Topics: Animals; Anti-Anxiety Agents; Anxiety; Azepines; Benzodiazepines; Diazepam; Hypnotics and Sedatives;	2008
The occasional D & C. Canadian journal of rural medicine : the official journal of the Society of Rural Physicians of Canada = Journal canadien de la medecine rurale : le journal officiel de la Societe de medecine rurale du Canada, 2009,Summer, Volume: 14, Issue:3 Topics: Anti-Anxiety Agents; Anti-Bacterial Agents; Anxiety; Dilatation and Curettage; Female; Humans; Loraz	2009
Fluoxetine-induced increases in open-field habituation in the olfactory bulbectomized rat depend on test aversiveness but not on anxiety. Pharmacology, biochemistry, and behavior, 2002, Volume: 73, Issue:3 Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Environment; Fluoxetine; Habituation, Psy	2002
Progesterone withdrawal increases the alpha4 subunit of the GABA(A) receptor in male rats in association with anxiety and altered pharmacology - a comparison with female rats. Neuropharmacology, 2002, Volume: 43, Issue:4 Topics: Animals; Anxiety; Blotting, Western; Female; Flumazenil; GABA Modulators; Hippocampus; Lorazepam; Ma	2002
Anxiogenic effects of neurosteroid exposure: sex differences and altered GABAA receptor pharmacology in adult rats. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:2 Topics: Acoustic Stimulation; Aging; Animals; Anti-Anxiety Agents; Anxiety; Exploratory Behavior; Female; Fl	2003
The Misericordia Health Centre cataract comfort study. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2003, Volume: 38, Issue:1 Topics: Anesthesia, Local; Anxiety; Cataract Extraction; Counseling; Humans; Hypnotics and Sedatives; Loraze	2003
Experimental anxiety and antiepileptics: the effects of valproate and vigabatrin in the mirrored chamber test. Methods and findings in experimental and clinical pharmacology, 2003, Volume: 25, Issue:4 Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Conflict, Psychological; Disease Models, Ani	2003
Blood pressure and heart rate of students undergoing a medical licensing examination. Blood pressure, 2004, Volume: 13, Issue:1 Topics: Adrenergic beta-Antagonists; Adult; Antidepressive Agents; Anxiety; Blood Pressure; Educational Meas	2004
The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal. Psychopharmacology, 2007, Volume: 192, Issue:3 Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Flumazenil; Gene Expression; Hypnotics and	2007
Pregabalin-induced remission in a 62-year-old woman with a 20-year history of vulvodynia. Pain research & management, 2007,Autumn, Volume: 12, Issue:3 Topics: Amitriptyline; Analgesics; Anti-Ulcer Agents; Anticoagulants; Antidepressive Agents; Anxiety; Cardio	2007
[The course of coronary heart disease and quality of life in patients with anxiety of different degree]. Terapevticheskii arkhiv, 2007, Volume: 79, Issue:12 Topics: Adult; Aged; Anti-Anxiety Agents; Anxiety; Coronary Disease; Emotions; Female; Humans; Lorazepam; Ma	2007
Fasciculations after rattlesnake envenomations: a retrospective statewide poison control system study. Clinical toxicology (Philadelphia, Pa.), 2008, Volume: 46, Issue:2 Topics: Adolescent; Adult; Animals; Antivenins; Anxiety; California; Child; Child, Preschool; Crotalus; Data	2008
Inadequate provision of postintubation anxiolysis and analgesia in the ED. The American journal of emergency medicine, 2008, Volume: 26, Issue:4 Topics: Adult; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Anxiety; Cohort Studies; Emergency Service, Ho	2008
Classification and assessment of cerebral bioavailability of lopirazepam (D-12524) by quantitative EEG and psychometric analysis. Arzneimittel-Forschung, 1980, Volume: 30, Issue:3 Topics: Adult; Anti-Anxiety Agents; Anxiety; Attention; Biological Availability; Brain; Double-Blind Method;	1980
Lorazepam withdrawal seizures. British medical journal, 1980, May-10, Volume: 280, Issue:6224 Topics: Adult; Anti-Anxiety Agents; Anxiety; Female; Humans; Lorazepam; Seizures; Substance Withdrawal Syndr	1980
Clinical comparisons. Psychosomatics, 1980, Volume: 21, Issue:Suppl Topics: Anti-Anxiety Agents; Anxiety; Diazepam; Humans; Lorazepam; Prognosis	1980
Child premedication per os with lorazepam. Acta anaesthesiologica Belgica, 1980, Volume: 31 Suppl Topics: Administration, Oral; Anesthesia, General; Anti-Anxiety Agents; Anxiety; Child; Child, Preschool; Do	1980
Choice of benzodiazepines. The Medical letter on drugs and therapeutics, 1981, May-01, Volume: 23, Issue:9 Topics: Aged; Anti-Anxiety Agents; Anxiety; Chlordiazepoxide; Diazepam; Flurazepam; Half-Life; Humans; Liver	1981
Plasma concentrations and clinical effects of lorazepam after oral administration. British journal of anaesthesia, 1981, Volume: 53, Issue:5 Topics: Administration, Oral; Adult; Anti-Anxiety Agents; Anxiety; Female; Half-Life; Humans; Kinetics; Lora	1981
Benzodiazepine withdrawal. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1981, Volume: 26, Issue:2 Topics: Anti-Anxiety Agents; Anxiety; Diazepam; Drug Tolerance; Humans; Lorazepam; Oxazepam; Sleep Initiatio	1981
Lorazepam and diazepam as adjuncts to epidural anaesthesia for caesarean section. Canadian Anaesthetists' Society journal, 1982, Volume: 29, Issue:1 Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anti-Anxiety Agents; Anxiety; Blood Pressure;	1982
[Preoperative anxiety and effect of lorazepam (author's transl)]. Masui. The Japanese journal of anesthesiology, 1982, Volume: 31, Issue:3 Topics: Adult; Anti-Anxiety Agents; Anxiety; Female; Flicker Fusion; Humans; Lorazepam; Male; Middle Aged; N	1982
The effect of clobazam and lorazepam on the psychomotor performance of anxious patients. British journal of clinical pharmacology, 1983, Volume: 16, Issue:1 Topics: Adolescent; Adult; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Benzodiazepinones; Clobazam; Doubl	1983
Clinical pharmacology of lorazepam. Contemporary anesthesia practice, 1983, Volume: 7 Topics: Adjuvants, Anesthesia; Anti-Anxiety Agents; Anxiety; Chemical Phenomena; Chemistry; Humans; Lorazepa	1983
Comparative anxiolytic and hypnotic effects of 3 benzodiazepines on baboons. Electroencephalography and clinical neurophysiology, 1980, Volume: 49, Issue:3-4 Topics: Animals; Anti-Anxiety Agents; Anxiety; Arousal; Diazepam; Electroencephalography; Evoked Potentials;	1980
Insomnia and psychotropic drug consumption. Progress in neuro-psychopharmacology & biological psychiatry, 1995, Volume: 19, Issue:3 Topics: Adolescent; Adult; Age Distribution; Aged; Anxiety; Benzodiazepines; Bromazepam; Female; Humans; Lor	1995
Flumazenil reversal of benzodiazepine-induced sedation for a patient with severe pre-ECT anxiety. Convulsive therapy, 1994, Volume: 10, Issue:1 Topics: Adult; Anti-Anxiety Agents; Anxiety; Electroconvulsive Therapy; Flumazenil; Humans; Lorazepam; Male;	1994
Intravenous lorazepam as an amnestic and anxiolytic agent in the intensive care unit: a prospective study. Critical care medicine, 1994, Volume: 22, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Amnesia, Retrograde; Anxiety; Catheterization, Central Venous; Cathe	1994
Failure of CCK receptor ligands to modify anxiety-related behavioural suppression in an operant conflict paradigm in rats. Psychopharmacology, 1995, Volume: 121, Issue:1 Topics: Animals; Anxiety; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Lorazep	1995
Effects of valproate and lorazepam on experimental anxiety: tolerance, withdrawal, and role of clonidine. Pharmacology, biochemistry, and behavior, 1995, Volume: 52, Issue:2 Topics: Adrenergic alpha-Agonists; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Clonidine; Dru	1995
Rat brain monoamine oxidase A and B inhibitory (tribulin) activity during drug withdrawal anxiety. Neuroscience letters, 1995, Oct-20, Volume: 199, Issue:2 Topics: Animals; Anxiety; Brain; Brain Chemistry; Cannabis; Ethanol; Isatin; Isoenzymes; Lorazepam; Male; Mo	1995
Anxiolytic activity of intraventricularly administered atrial natriuretic peptide in the rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1996, Volume: 15, Issue:2 Topics: Animals; Anxiety; Atrial Natriuretic Factor; Behavior, Animal; Drug Interactions; Feeding Behavior;	1996
Can we use anxiolytics during pregnancy without anxiety? Canadian family physician Medecin de famille canadien, 2000, Volume: 46 Topics: Anti-Anxiety Agents; Anxiety; Cleft Palate; Female; Humans; Infant, Newborn; Lorazepam; Practice Gui	2000
Direct demonstration of the effect of lorazepam on the excitability of the human motor cortex. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2000, Volume: 111, Issue:5 Topics: Aged; Anti-Anxiety Agents; Anxiety; Electric Stimulation Therapy; Electromyography; Functional Later	2000
Anxiolytic activity of Indian Abies pindrow Royle leaves in rodents: an experimental study. Indian journal of experimental biology, 2000, Volume: 38, Issue:4 Topics: Animals; Anti-Anxiety Agents; Anxiety; Exploratory Behavior; Female; Lorazepam; Male; Maze Learning;	2000
Successful management of claustrophobia and depression during allogeneic SCT. European journal of haematology, 2001, Volume: 67, Issue:1 Topics: Adult; Anti-Anxiety Agents; Anxiety; Cognitive Behavioral Therapy; Combined Modality Therapy; Cranio	2001
Lorazepam. Neonatal network : NN, 2000, Volume: 19, Issue:8 Topics: Anti-Anxiety Agents; Anxiety; Asphyxia Neonatorum; Dose-Response Relationship, Drug; Female; Humans;	2000
Anxiety therapy in the neoplastic patient. Current medical research and opinion, 1976, Volume: 4, Issue:3 Topics: Adult; Aged; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Female; Humans; Lorazepam; Male; Middl	1976
[Use of an anxiolytic agent (lorazepam) in low doses in the treatment of anxiety states]. Minerva medica, 1977, Jul-28, Volume: 68, Issue:36 Topics: Adult; Aged; Anti-Anxiety Agents; Anxiety; Drug Evaluation; Female; Humans; Lorazepam; Male; Middle	1977
Lorazepam in anxiety with GI disorders. Psychosomatics, 1977, Volume: 18, Issue:3 Topics: Anti-Anxiety Agents; Anxiety; Double-Blind Method; Drug Evaluation; Female; Gastrointestinal Disease	1977
Clinical trial with lorazepam in pre-operative anxiety. Acta anaesthesiologica Belgica, 1977, Volume: 28, Issue:2 Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Anxiety; Female; Humans; Lorazepam; Male; Memory; Midd	1977
Lorazepam (Ativan). The Medical letter on drugs and therapeutics, 1978, Mar-24, Volume: 20, Issue:6 Topics: Anti-Anxiety Agents; Anxiety; Drug Evaluation; Humans; Lorazepam	1978
Management of acute anxiety syndrome with parenterally administered lorazepam. The Journal of international medical research, 1978, Volume: 6, Issue:3 Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Female; Humans; Hysteria;	1978
[Psychophysiologic characteristics of the individual psychotropic activity of benzodiazepine derivatives under experimental conditions]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1978, Volume: 78, Issue:6 Topics: Animals; Anti-Anxiety Agents; Anxiety; Cats; Chlordiazepoxide; Diazepam; Humans; Lorazepam; Neurotic	1978
Clinical profile of lorazepam, a new benzodiazepine tranquilizer. The Journal of clinical psychiatry, 1978, Volume: 39, Issue:10 Pt 2 Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Anti-Anxiety Agents; Anxiety; Anxiety Di	1978
Anxiety associated with cardiovascular disorders: a study using lorazepam. Psychosomatics, 1979, Volume: 20, Issue:10 Topics: Adult; Aged; Anti-Anxiety Agents; Anxiety; Cardiovascular Diseases; Double-Blind Method; Female; Hum	1979
Persistent psychiatric symptoms after eating psilocybin mushrooms. British medical journal, 1979, May-19, Volume: 1, Issue:6174 Topics: Adult; Anxiety; Basidiomycota; Humans; Jurisprudence; Lorazepam; Male; Psilocybin	1979
The anxiogenic-like effects of pentylenetetrazole in mice treated chronically with carbamazepine or valproate. Methods and findings in experimental and clinical pharmacology, 1992, Volume: 14, Issue:10 Topics: Animals; Anxiety; Behavior, Animal; Carbamazepine; Female; Lorazepam; Mice; Pentylenetetrazole; Valp	1992
Comparison of behavioral effects after single and repeated administrations of four benzodiazepines in three mice behavioral models. Journal of psychiatry & neuroscience : JPN, 1992, Volume: 17, Issue:2 Topics: Alprazolam; Animals; Anxiety; Behavior, Animal; Benzodiazepines; Bromazepam; Dose-Response Relations	1992
Measuring anxiety in nonhuman primates: effect of lorazepam on macaque scratching. Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:4 Topics: Animals; Anxiety; Behavior, Animal; Female; Lorazepam; Macaca fascicularis	1991
Use of lorazepam for increased anxiety after neuroleptic dose reduction. Hospital & community psychiatry, 1990, Volume: 41, Issue:2 Topics: Antipsychotic Agents; Anxiety; Combined Modality Therapy; Humans; Lorazepam; Male; Middle Aged; Schi	1990
Delayed recovery following lorazepam premedication. The Medical journal of Malaysia, 1990, Volume: 45, Issue:3 Topics: Administration, Oral; Adult; Anesthesia Recovery Period; Anxiety; Female; Genital Diseases, Female;	1990
Tranquilizers and sedative/hypnotics: appropriate use in the elderly. Geriatrics, 1986, Volume: 41, Issue:5 Topics: Aged; Alprazolam; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Half-Life; Humans; Hypnotics and Se	1986
[Oral premedication with bromazepam and lorazepam]. Cahiers d'anesthesiologie, 1986, Volume: 34, Issue:8 Topics: Anesthesia, General; Anti-Anxiety Agents; Anxiety; Bromazepam; Humans; Lorazepam; Middle Aged; Prean	1986
Flumazenil and benzodiazepine withdrawal. Lancet (London, England), 1987, Aug-22, Volume: 2, Issue:8556 Topics: Animals; Anxiety; Benzodiazepines; Flumazenil; Lorazepam; Male; Mice; Rats; Rats, Inbred Strains; Re	1987
Is midazolam a dangerous drug? Journal of post anesthesia nursing, 1989, Volume: 4, Issue:1 Topics: Anxiety; Diazepam; Humans; Lorazepam; Midazolam	1989
Tolerance to the benzodiazepine diazepam in an animal model of anxiolytic activity. Psychopharmacology, 1985, Volume: 87, Issue:3 Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo C	1985
Withdrawal, tolerance and sensitization after a single dose of lorazepam. Pharmacology, biochemistry, and behavior, 1988, Volume: 31, Issue:4 Topics: Animals; Anxiety; Behavior, Animal; Drug Tolerance; Lorazepam; Male; Mice; Motor Activity; Time Fact	1988
Lorazepam sublingual for the nervous dental patient. Journal (Canadian Dental Association), 1988, Volume: 54, Issue:1 Topics: Administration, Sublingual; Anxiety; Dental Care; Humans; Lorazepam; Preanesthetic Medication; Time	1988
Ineffective sublingual lorazepam: considerations. Journal of clinical psychopharmacology, 1987, Volume: 7, Issue:5 Topics: Administration, Sublingual; Anxiety; Female; Humans; Lorazepam; Middle Aged	1987
[Temesta]. Soins. Psychiatrie, 1985, Issue:55 Topics: Aged; Anxiety; Depressive Disorder; Female; Humans; Lorazepam; Male; Pregnancy	1985
Use of lorazepam as premedication for apprehensive children. The Journal of pedodontics, 1985,Winter, Volume: 9, Issue:2 Topics: Anesthesia, Dental; Anxiety; Child; Child, Preschool; Double-Blind Method; Female; Humans; Lorazepam	1985
Lorazepam in cancer patients treated with cisplatin: a drug having antiemetic, amnesic, and anxiolytic effects. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:6 Topics: Adult; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Anxiety; Cisplatin; Female; Huma	1985
Transient global amnesia induced by lorazepam. Clinical neuropharmacology, 1985, Volume: 8, Issue:3 Topics: Aged; Amnesia; Anxiety; Female; Humans; Lorazepam; Memory, Short-Term; Time Factors	1985
Lorazepam--a benzodiazepine to choose or avoid? Drug and therapeutics bulletin, 1985, Aug-12, Volume: 23, Issue:16 Topics: Anxiety; Humans; Kinetics; Lorazepam	1985
Pain, anxiety, and contingent negative variation: a clinical and pharmacological study. Biological psychiatry, 1985, Volume: 20, Issue:12 Topics: Adult; Anxiety; Contingent Negative Variation; Electrophysiology; Female; Humans; Lorazepam; Male; M	1985

lorazepam and Anxiety