lorazepam has been researched along with Alcohol Withdrawal Associated Autonomic Hyperactivity in 32 studies
Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
| Excerpt | Relevance | Reference |
|---|---|---|
| " He received a high-dose lorazepam infusion for alcohol withdrawal during hospitalization and developed severe hyperosmolality, high anion gap metabolic acidosis, and acute kidney injury on his eighth day of hospitalization." | 7.74 | Acute kidney injury, hyperosmolality and metabolic acidosis associated with lorazepam. ( Graeber, C; Sullivan, A; Yusufzai, I; Zar, T, 2007) |
| " He received a high-dose lorazepam infusion for alcohol withdrawal during hospitalization and developed severe hyperosmolality, high anion gap metabolic acidosis, and acute kidney injury on his eighth day of hospitalization." | 3.74 | Acute kidney injury, hyperosmolality and metabolic acidosis associated with lorazepam. ( Graeber, C; Sullivan, A; Yusufzai, I; Zar, T, 2007) |
| "Studies show that symptom-triggered dosing is best for treatment of alcohol withdrawal in patients on chemical dependence wards without other illness." | 2.72 | Alcohol withdrawal pharmacotherapy for inpatients with medical comorbidity. ( Hoffman, HJ; Johnson, RE; Mauck, K; Weaver, MF, 2006) |
| "Lorazepam is an excellent first choice because of its intermediate half-life, absence of active metabolites, and high bioavailability that can be achieved with a number of routes of administration." | 2.37 | Emerging treatment options in the alcohol withdrawal syndrome. ( Rosenbloom, A, 1988) |
| "Severe AWS can develop into delirium tremens (DT), which is potentially life-threatening." | 1.51 | Lorazepam versus chlordiazepoxide for the treatment of alcohol withdrawal syndrome and prevention of delirium tremens in general medicine ward patients. ( Bergeron, JB; March, KL; Reaves, AB; Sakaan, SA; Self, TH; Slayton, MM; Twilla, JD, 2019) |
| "Propofol has been reported to have successfully relieved alcohol withdrawal syndrome (AWS) symptoms in part because of activation of γ-aminobutyric acid channels in combination with antagonism of excitatory amino acids such as N-methyl-D-aspartate." | 1.40 | Propofol for benzodiazepine-refractory alcohol withdrawal in a non-mechanically ventilated patient. ( Adams, BD; Hughes, DW; Lepori, L; Vanwert, E, 2014) |
| "The manifestations of delirium tremens persisted with titration of a lorazepam infusion in excess of 40 mg/hour." | 1.35 | Phenobarbital treatment in a patient with resistant alcohol withdrawal syndrome. ( Bolton, PJ; Hayner, CE; Wuestefeld, NL, 2009) |
| "To compare outcomes of treating alcohol withdrawal delirium (AWD) with a symptom-driven benzodiazepine protocol versus nonprotocol benzodiazepine infusions in the intensive care unit (ICU)." | 1.34 | Symptom-driven lorazepam protocol for treatment of severe alcohol withdrawal delirium in the intensive care unit. ( Cassaro, S; DeCarolis, DD; Ho, L; Rice, KL; Willenbring, ML, 2007) |
| "Alcohol withdrawal (especially delirium tremens) poses significant potential morbidity to postsurgical patients." | 1.29 | Trends in the management of alcohol withdrawal syndrome. ( Moore, M; Newman, JP; Terris, DJ, 1995) |
| "Inappropriate benzodiazepine dosing in patients exhibiting signs of alcohol withdrawal cause staff and patient safety problems." | 1.29 | Nursing-based protocol for treatment of alcohol withdrawal in the intensive care unit. ( Casey, P; Fleming, C; Watling, SM; Yanos, J, 1995) |
| "This resulted in a comatose state with depression of some brainstem reflexes." | 1.27 | Spindle coma in benzodiazepine toxicity: case report. ( Mouradian, MD; Penovich, PE, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (15.63) | 18.7374 |
| 1990's | 6 (18.75) | 18.2507 |
| 2000's | 12 (37.50) | 29.6817 |
| 2010's | 8 (25.00) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Levine, AR | 1 |
| Thanikonda, V | 1 |
| Mueller, J | 1 |
| Naut, ER | 1 |
| Muzyk, AJ | 1 |
| Rogers, RE | 1 |
| Dighe, G | 1 |
| Hartung, J | 1 |
| Musser, RC | 1 |
| Stillwagon, MJ | 1 |
| Rivelli, S | 1 |
| Ram, D | 1 |
| Raman, R | 1 |
| Gowdappa, B | 1 |
| Knight, E | 1 |
| Lappalainen, L | 1 |
| March, KL | 1 |
| Twilla, JD | 1 |
| Reaves, AB | 1 |
| Self, TH | 1 |
| Slayton, MM | 1 |
| Bergeron, JB | 1 |
| Sakaan, SA | 1 |
| Hughes, DW | 1 |
| Vanwert, E | 1 |
| Lepori, L | 1 |
| Adams, BD | 1 |
| Schuckit, MA | 1 |
| Hayner, CE | 1 |
| Wuestefeld, NL | 1 |
| Bolton, PJ | 1 |
| Kahn, DR | 1 |
| Barnhorst, AV | 1 |
| Bourgeois, JA | 1 |
| Riddle, E | 1 |
| Bush, J | 1 |
| Tittle, M | 1 |
| Dilkhush, D | 1 |
| Huang, MC | 1 |
| Chen, CH | 1 |
| Liu, HC | 1 |
| Chen, CC | 1 |
| Ho, CC | 1 |
| Leu, SJ | 1 |
| Hilliard, NJ | 1 |
| Robinson, CA | 1 |
| Hardy, R | 1 |
| Daly, TM | 1 |
| Schmidt, LG | 1 |
| Bleich, S | 1 |
| Boening, J | 1 |
| Buehringer, G | 1 |
| Kornhuber, J | 1 |
| Weijers, HG | 1 |
| Wiesbeck, GA | 1 |
| Wolfgramm, J | 1 |
| Havemann-Reinecke, U | 1 |
| Stanley, KM | 1 |
| Worrall, CL | 1 |
| Lunsford, SL | 1 |
| Simpson, KN | 1 |
| Miller, JG | 1 |
| Spencer, AP | 1 |
| Weaver, MF | 1 |
| Hoffman, HJ | 1 |
| Johnson, RE | 1 |
| Mauck, K | 1 |
| DeCarolis, DD | 1 |
| Rice, KL | 1 |
| Ho, L | 1 |
| Willenbring, ML | 1 |
| Cassaro, S | 1 |
| Cole, RP | 1 |
| Ash, J | 1 |
| Zar, T | 1 |
| Yusufzai, I | 1 |
| Sullivan, A | 1 |
| Graeber, C | 1 |
| Spencer, J | 1 |
| Newman, JP | 1 |
| Terris, DJ | 1 |
| Moore, M | 1 |
| Watling, SM | 1 |
| Fleming, C | 1 |
| Casey, P | 1 |
| Yanos, J | 1 |
| Bird, RD | 1 |
| Makela, EH | 1 |
| Volkow, ND | 1 |
| Wang, GJ | 1 |
| Overall, JE | 1 |
| Hitzemann, R | 1 |
| Fowler, JS | 1 |
| Pappas, N | 1 |
| Frecska, E | 1 |
| Piscani, K | 1 |
| Prater, CD | 1 |
| Miller, KE | 1 |
| Zylstra, RG | 1 |
| Myrick, H | 1 |
| Brady, KT | 1 |
| Malcolm, R | 1 |
| Schumacher, L | 1 |
| Pruitt, JN | 1 |
| Phillips, M | 1 |
| Longo, LP | 1 |
| Campbell, T | 1 |
| Hubatch, S | 1 |
| Hosein, IN | 2 |
| de Freitas, R | 2 |
| Beaubrun, MH | 2 |
| Sullivan, JT | 1 |
| Swift, RM | 1 |
| Lewis, DC | 1 |
| Rosenbloom, A | 1 |
| Mouradian, MD | 1 |
| Penovich, PE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of N-acetylcysteine (NAC) on Treatment of Alcohol and Cocaine Use Disorders: A Double-Blind Randomized Controlled Trial.[NCT03018236] | Phase 4 | 100 participants (Anticipated) | Interventional | 2017-01-31 | Recruiting | ||
| Acute Drug Withdrawal in a General Medical Setting[NCT00249366] | Phase 4 | 183 participants (Actual) | Interventional | 2001-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for lorazepam and Alcohol Withdrawal Associated Autonomic Hyperactivity
| Article | Year |
|---|---|
Recognition and management of withdrawal delirium (delirium tremens).
Topics: Alcohol Withdrawal Delirium; Benzodiazepines; Central Nervous System Depressants; Diazepam; Disease | 2014 |
Alcohol withdrawal: what is the benzodiazepine of choice?
Topics: Alcohol Withdrawal Delirium; Benzodiazepines; Chlordiazepoxide; Clinical Trials as Topic; Diazepam; | 1994 |
Outpatient detoxification of the addicted or alcoholic patient.
Topics: Alcohol Withdrawal Delirium; Alcoholic Intoxication; Ambulatory Care; Anti-Anxiety Agents; Chlordiaz | 1999 |
Emerging treatment options in the alcohol withdrawal syndrome.
Topics: Adrenergic beta-Antagonists; Alcohol Withdrawal Delirium; Benzodiazepines; Drug Therapy, Combination | 1988 |
4 trials available for lorazepam and Alcohol Withdrawal Associated Autonomic Hyperactivity
| Article | Year |
|---|---|
Alcohol withdrawal pharmacotherapy for inpatients with medical comorbidity.
Topics: Academic Medical Centers; Adult; Aged; Alcohol Withdrawal Delirium; Cohort Studies; Comorbidity; Dos | 2006 |
Regional brain metabolic response to lorazepam in alcoholics during early and late alcohol detoxification.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Blood Glucose; Brain; Brain Mapping; Energy Metaboli | 1997 |
Divalproex in the treatment of alcohol withdrawal.
Topics: Adult; Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Anticonvulsants; Female; Humans; Lorazepam; | 2000 |
Divalproex sodium (Depakote) for alcohol withdrawal and relapse prevention.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Ambulatory Care; Anti-Anxiety Agents; Anticonvulsant | 2002 |
24 other studies available for lorazepam and Alcohol Withdrawal Associated Autonomic Hyperactivity
| Article | Year |
|---|---|
Front-loaded diazepam versus lorazepam for treatment of alcohol withdrawal agitated delirium.
Topics: Alcohol Withdrawal Delirium; Biomarkers; Diazepam; Emergency Service, Hospital; Female; Humans; Hypn | 2021 |
Impact of an Alcohol Withdrawal Treatment Pathway on Hospital Length of Stay: A Retrospective Observational Study Comparing Pre and Post Pathway Implementation.
Topics: Alcohol Withdrawal Delirium; Drug Administration Schedule; Evidence-Based Medicine; Female; Hospital | 2017 |
Lorazepam precipitated alcohol withdrawal delirium - Two case report.
Topics: Alcohol Withdrawal Delirium; Antipsychotic Agents; Drug Administration Schedule; Female; GABA Modula | 2017 |
Clinical Institute Withdrawal Assessment for Alcohol-Revised might be an unreliable tool in the management of alcohol withdrawal.
Topics: Alcohol Withdrawal Delirium; Clinical Protocols; Communication Barriers; Diazepam; Humans; Hypnotics | 2017 |
Lorazepam versus chlordiazepoxide for the treatment of alcohol withdrawal syndrome and prevention of delirium tremens in general medicine ward patients.
Topics: Alcohol Withdrawal Delirium; Chlordiazepoxide; Ethanol; Female; Humans; Hypnotics and Sedatives; Inp | 2019 |
Propofol for benzodiazepine-refractory alcohol withdrawal in a non-mechanically ventilated patient.
Topics: Adult; Alcohol Withdrawal Delirium; Diazepam; Emergency Service, Hospital; Haloperidol; Humans; Hypn | 2014 |
Phenobarbital treatment in a patient with resistant alcohol withdrawal syndrome.
Topics: Adult; Alcohol Withdrawal Delirium; Dose-Response Relationship, Drug; Drug Resistance; Humans; Hypno | 2009 |
A case of alcohol withdrawal requiring 1,600 mg of lorazepam in 24 hours.
Topics: Adult; Alcohol Withdrawal Delirium; Humans; Hypnotics and Sedatives; Lorazepam; Male; Severity of Il | 2009 |
Alcohol withdrawal: development of a standing order set.
Topics: Adult; Aged; Alcohol Withdrawal Delirium; Chlordiazepoxide; Clinical Protocols; Critical Care; Drug | 2010 |
Differential patterns of serum brain-derived neurotrophic factor levels in alcoholic patients with and without delirium tremens during acute withdrawal.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Anticonvulsants; Brain-Derived Neurotrophic Factor; | 2011 |
Pathologic quiz case: repeated positive ethylene glycol levels by gas chromatography. Central venous line contamination of blood samples by propylene glycol from intravenous lorazepam injections.
Topics: Adult; Alcohol Withdrawal Delirium; Catheterization, Central Venous; Chromatography, Gas; Ethylene G | 2004 |
Advances in alcoholism research in Germany.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Brain; Comorbidity; Dopamine; Early Diagnosis; gam | 2005 |
Experience with an adult alcohol withdrawal syndrome practice guideline in internal medicine patients.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Antipsycho | 2005 |
Symptom-driven lorazepam protocol for treatment of severe alcohol withdrawal delirium in the intensive care unit.
Topics: Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Benzodiazepines; Clinical Protocols; Drug Administ | 2007 |
Benzodiazepine administration and need for mechanical ventilation in delirium tremens.
Topics: Alcohol Withdrawal Delirium; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Lorazepam; Res | 2007 |
Acute kidney injury, hyperosmolality and metabolic acidosis associated with lorazepam.
Topics: Acidosis; Acute Kidney Injury; Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Drug Compounding; H | 2007 |
Use of injectable lorazepam in alcohol withdrawal.
Topics: Adult; Aged; Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Female; Humans; Injections, Intramusc | 1980 |
Trends in the management of alcohol withdrawal syndrome.
Topics: Adult; Aged; Aged, 80 and over; Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Chlordiazepoxide; | 1995 |
Nursing-based protocol for treatment of alcohol withdrawal in the intensive care unit.
Topics: Alcohol Withdrawal Delirium; Clinical Protocols; Critical Care; Drug Monitoring; Humans; Lorazepam; | 1995 |
Identifying patients "at risk" for alcohol withdrawal syndrome and a treatment protocol.
Topics: Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Algorithms; Anti-Anxiety Agents; Clinical | 2000 |
Intramuscular/oral lorazepam in acute alcohol withdrawal and incipient delirium tremens.
Topics: Administration, Oral; Adult; Alcohol Withdrawal Delirium; Alcoholism; Anti-Anxiety Agents; Female; H | 1978 |
Intramuscular/oral lorazepam in acute alcohol withdrawal and incipient delirium tremens.
Topics: Acute Disease; Adult; Alcohol Withdrawal Delirium; Alcoholism; Anti-Anxiety Agents; Female; Humans; | 1979 |
Benzodiazepine requirements during alcohol withdrawal syndrome: clinical implications of using a standardized withdrawal scale.
Topics: Administration, Oral; Adult; Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Chlordiazepoxide; Dia | 1991 |
Spindle coma in benzodiazepine toxicity: case report.
Topics: Adult; Alcohol Withdrawal Delirium; Coma; Diazepam; Drug Therapy, Combination; Electroencephalograph | 1985 |