lorazepam has been researched along with Aging in 26 studies
Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This randomized control study was conducted to compare the efficacy of sodium valproate (SVP) and levetiracetam (LEV) following initial intravenous lorazepam in elderly patients (age: >60years) with generalized convulsive status epilepticus (GCSE) and to identify predictors of poor seizure control." | 9.30 | Comparing the efficacy of sodium valproate and levetiracetam following initial lorazepam in elderly patients with generalized convulsive status epilepticus (GCSE): A prospective randomized controlled pilot study. ( Bharath, RD; Bindu, PS; Mundlamuri, RC; Nagappa, M; Nene, D; Prathyusha, PV; Raghavendra, K; Saini, J; Satishchandra, P; Sinha, S; Taly, AB; Thennarasu, K, 2019) |
| "Practice guidelines recommend the use of low dose haloperidol when medication is needed to treat delirium with acute agitation in hospitalized older people." | 7.79 | Haloperidol overdosing in the treatment of agitated hospitalized older people with delirium: a retrospective chart review from a community teaching hospital. ( Dorokhine, I; Knapp, CM; Musuku, M; Patel, N; Zirker, W, 2013) |
| " Determining benzodiazepines that do not produce pharmacodynamic sensitivity, such as lorazepam, may allow more careful prescribing and dosing of these drugs, and perhaps even the development of specific agents which could avoid this sensitivity." | 5.33 | The effect of chronic lorazepam administration in aging mice. ( Fahey, JM; Grassi, JM; Greenblatt, DJ; Pratt, JS; Pritchard, GA; Reddi, JM; Shader, RI, 2006) |
| "This randomized control study was conducted to compare the efficacy of sodium valproate (SVP) and levetiracetam (LEV) following initial intravenous lorazepam in elderly patients (age: >60years) with generalized convulsive status epilepticus (GCSE) and to identify predictors of poor seizure control." | 5.30 | Comparing the efficacy of sodium valproate and levetiracetam following initial lorazepam in elderly patients with generalized convulsive status epilepticus (GCSE): A prospective randomized controlled pilot study. ( Bharath, RD; Bindu, PS; Mundlamuri, RC; Nagappa, M; Nene, D; Prathyusha, PV; Raghavendra, K; Saini, J; Satishchandra, P; Sinha, S; Taly, AB; Thennarasu, K, 2019) |
| "Practice guidelines recommend the use of low dose haloperidol when medication is needed to treat delirium with acute agitation in hospitalized older people." | 3.79 | Haloperidol overdosing in the treatment of agitated hospitalized older people with delirium: a retrospective chart review from a community teaching hospital. ( Dorokhine, I; Knapp, CM; Musuku, M; Patel, N; Zirker, W, 2013) |
| "The purpose of this study was to measure forelimb force control and movement kinetics in rats, as they are affected by normal aging and the benzodiazepine lorazepam." | 3.73 | Measuring forelimb force control and movement in Fischer 344/Brown Norway rats: effects of age and lorazepam. ( Fowler, SC; Osterhaus, GL; Stanford, JA; Vorontsova, E, 2006) |
| "Aging is associated with cognitive impairment, but there are large individual differences in these declines." | 3.01 | Dynamic Recovery: GABA Agonism Restores Neural Variability in Older, Poorer Performing Adults. ( Garrett, DD; Lalwani, P; Polk, TA, 2021) |
| "Lormetazepam is a new benzodiazepine hypnotic." | 2.65 | Sleep laboratory study of lormetazepam in older insomniacs. ( Vogel, GW, 1984) |
| "We previously verified a physiologically based pharmacokinetic (PBPK) model for mirabegron in healthy subjects using the Simcyp Simulator by incorporating data on the inhibitory effect on cytochrome P450 (CYP) 2D6 and a multi-elimination pathway mediated by CYP3A4, uridine 5'-diphosphate-glucuronosyltransferase (UGT) 2B7 and butyrylcholinesterase (BChE)." | 1.51 | Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment. ( Konishi, K; Minematsu, T; Nagasaka, Y; Tabata, K, 2019) |
| "We utilized a middle cerebral artery occlusion model and examined seizure activity and brain injury using combined behavioral and electroencephalographic monitoring and histological assessments." | 1.42 | Modeling early-onset post-ischemic seizures in aging mice. ( Aljarallah, S; Eubanks, JH; Gao, X; Huang, Y; McDonald, R; Patel, N; Peng, J; Wang, J; Wu, C; Zhang, L, 2015) |
| "With either etiology, seizures are a poor prognostic factor." | 1.42 | Early-Onset Convulsive Seizures Induced by Brain Hypoxia-Ischemia in Aging Mice: Effects of Anticonvulsive Treatments. ( Aljarallah, S; Eubanks, JH; Gao, X; Huang, Y; McDonald, R; Patel, N; Peng, J; Wang, J; Wu, C; Zhang, L, 2015) |
| " Determining benzodiazepines that do not produce pharmacodynamic sensitivity, such as lorazepam, may allow more careful prescribing and dosing of these drugs, and perhaps even the development of specific agents which could avoid this sensitivity." | 1.33 | The effect of chronic lorazepam administration in aging mice. ( Fahey, JM; Grassi, JM; Greenblatt, DJ; Pratt, JS; Pritchard, GA; Reddi, JM; Shader, RI, 2006) |
| "The elimination half-life of chlordiazepoxide and diazepam increases with age, and this may cause prolongation of action after a single dose and delayed accumulation on multiple dosing in elderly patients." | 1.26 | [Pharmacokinetic of benzodiazepines in old age]. ( Vozeh, S, 1981) |
| "Lorazepam is a 3-hydroxy-1,4-benzodiazepine derivative biotransformed by glucuronide conjugation, followed by urinary excretion of the glucuronide metabolite." | 1.26 | Lorazepam kinetics in the elderly. ( Allen, MD; Greenblatt, DJ; Harmatz, JS; Locniskar, A; Shader, RI, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (42.31) | 18.7374 |
| 1990's | 3 (11.54) | 18.2507 |
| 2000's | 5 (19.23) | 29.6817 |
| 2010's | 6 (23.08) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Lalwani, P | 1 |
| Garrett, DD | 1 |
| Polk, TA | 1 |
| Nene, D | 1 |
| Mundlamuri, RC | 1 |
| Satishchandra, P | 1 |
| Prathyusha, PV | 1 |
| Nagappa, M | 1 |
| Bindu, PS | 1 |
| Raghavendra, K | 1 |
| Saini, J | 1 |
| Bharath, RD | 1 |
| Thennarasu, K | 1 |
| Taly, AB | 1 |
| Sinha, S | 1 |
| Konishi, K | 1 |
| Minematsu, T | 1 |
| Nagasaka, Y | 1 |
| Tabata, K | 1 |
| Zirker, W | 1 |
| Dorokhine, I | 1 |
| Knapp, CM | 1 |
| Patel, N | 3 |
| Musuku, M | 1 |
| Wu, C | 2 |
| Wang, J | 2 |
| Peng, J | 2 |
| Huang, Y | 2 |
| Gao, X | 2 |
| Aljarallah, S | 2 |
| Eubanks, JH | 2 |
| McDonald, R | 2 |
| Zhang, L | 2 |
| Hulin, MW | 1 |
| Amato, RJ | 1 |
| Winsauer, PJ | 1 |
| Gulinello, M | 1 |
| Smith, SS | 1 |
| Pomara, N | 1 |
| Willoughby, L | 1 |
| Wesnes, K | 1 |
| Greenblatt, DJ | 5 |
| Sidtis, JJ | 1 |
| Fahey, JM | 1 |
| Pritchard, GA | 1 |
| Reddi, JM | 1 |
| Pratt, JS | 1 |
| Grassi, JM | 1 |
| Shader, RI | 3 |
| Stanford, JA | 1 |
| Osterhaus, GL | 1 |
| Vorontsova, E | 1 |
| Fowler, SC | 1 |
| Vozeh, S | 1 |
| Divoll, M | 1 |
| Vogel, GW | 1 |
| Léger, JM | 2 |
| Herrmann, C | 2 |
| Danot, G | 2 |
| Malauzat, D | 2 |
| Lombertie, ER | 2 |
| Fluck, E | 1 |
| Fernandes, C | 1 |
| File, SE | 1 |
| Hoyumpa, AM | 1 |
| Kraus, JW | 1 |
| Desmond, PV | 1 |
| Marshall, JP | 1 |
| Johnson, RF | 1 |
| Schenker, S | 2 |
| Wilkinson, GR | 2 |
| Allen, MD | 1 |
| Locniskar, A | 1 |
| Harmatz, JS | 1 |
| Miller, LG | 1 |
| Lumpkin, M | 1 |
| Galpern, WR | 1 |
| Satzger, W | 1 |
| Engel, RR | 1 |
| Ferguson, E | 1 |
| Kapfhammer, H | 1 |
| Eich, FX | 1 |
| Hippius, H | 1 |
| Deijen, JB | 1 |
| Heemstra, ML | 1 |
| Orlebeke, JF | 1 |
| Overstall, PW | 1 |
| Oldman, PN | 1 |
8 trials available for lorazepam and Aging
| Article | Year |
|---|---|
Dynamic Recovery: GABA Agonism Restores Neural Variability in Older, Poorer Performing Adults.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Brain; Cognition; Female; GABA Modulators; Humans | 2021 |
Comparing the efficacy of sodium valproate and levetiracetam following initial lorazepam in elderly patients with generalized convulsive status epilepticus (GCSE): A prospective randomized controlled pilot study.
Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Dose-Response Relationship, Drug; Electroencephalog | 2019 |
Sleep laboratory study of lormetazepam in older insomniacs.
Topics: Aged; Aging; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; El | 1984 |
[Double-blind comparative study of lorazepam and tiapride effects on the memory capacities of subjects over 60 years of age].
Topics: Aging; Analysis of Variance; Benzamides; Clinical Trials as Topic; Double-Blind Method; Female; Huma | 1984 |
Are lorazepam-induced deficits in attention similar to those resulting from aging?
Topics: Adult; Age Factors; Aging; Analysis of Variance; Attention; Female; GABA Modulators; Humans; Lorazep | 2001 |
Effects of single doses of alpidem, lorazepam, and placebo on memory and attention in healthy young and elderly volunteers.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Amnesia; Anti-Anxiety Agents; Attention; Cognitio | 1990 |
Residual effects of lormetazepam on mood and performance in healthy elderly volunteers.
Topics: Affect; Aged; Aging; Anti-Anxiety Agents; Benzodiazepines; Cognition; Female; Humans; Hypnotics and | 1991 |
A comparative study of lormetazepam and chlormethiazole in elderly in-patients.
Topics: Aged; Aged, 80 and over; Aging; Anti-Anxiety Agents; Benzodiazepines; Chlormethiazole; Clinical Tria | 1987 |
18 other studies available for lorazepam and Aging
| Article | Year |
|---|---|
Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment.
Topics: Acetanilides; Adolescent; Adrenergic beta-3 Receptor Agonists; Adult; Aged; Aging; Butyrylcholineste | 2019 |
Haloperidol overdosing in the treatment of agitated hospitalized older people with delirium: a retrospective chart review from a community teaching hospital.
Topics: Aged; Aged, 80 and over; Aging; Anti-Anxiety Agents; Delirium; Dopamine Antagonists; Dose-Response R | 2013 |
Modeling early-onset post-ischemic seizures in aging mice.
Topics: Aging; Analysis of Variance; Animals; Anticonvulsants; Brain; Chi-Square Distribution; Disease Model | 2015 |
Early-Onset Convulsive Seizures Induced by Brain Hypoxia-Ischemia in Aging Mice: Effects of Anticonvulsive Treatments.
Topics: Age of Onset; Aging; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Hippocampus; | 2015 |
GABA(A) receptor modulation during adolescence alters adult ethanol intake and preference in rats.
Topics: Aging; Alcohol Drinking; Animals; Data Interpretation, Statistical; Dehydroepiandrosterone; Dose-Res | 2012 |
Anxiogenic effects of neurosteroid exposure: sex differences and altered GABAA receptor pharmacology in adult rats.
Topics: Acoustic Stimulation; Aging; Animals; Anti-Anxiety Agents; Anxiety; Exploratory Behavior; Female; Fl | 2003 |
Apolipoprotein E epsilon4 allele and lorazepam effects on memory in high-functioning older adults.
Topics: Aged; Aging; Alleles; Apolipoprotein E4; Apolipoproteins E; Dose-Response Relationship, Drug; Geneti | 2005 |
The effect of chronic lorazepam administration in aging mice.
Topics: Aging; Animals; Brain; Cerebral Cortex; Convulsants; Drug Administration Schedule; Drug Interactions | 2006 |
Measuring forelimb force control and movement in Fischer 344/Brown Norway rats: effects of age and lorazepam.
Topics: Aging; Animals; Anti-Anxiety Agents; Conditioning, Operant; Forelimb; Hypnotics and Sedatives; Loraz | 2006 |
[Pharmacokinetic of benzodiazepines in old age].
Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Half-Life; Humans; Lorazepam; M | 1981 |
Effect of age and sex on lorazepam protein binding.
Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Blood Proteins; Female; Humans; Kinetics; Lorazepam; Male; | 1982 |
[Anxiolytics and mnemonic ability of the aged subject. Apropos of a double-blind study between tiapride and lorazepam].
Topics: Aged; Aging; Arousal; Attention; Benzamides; Double-Blind Method; Humans; Lorazepam; Memory; Memory | 1984 |
Disposition and elimination of minor tranquilizers in the aged and in patients with liver disease.
Topics: Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Hepatitis; Humans; Liver Cirrhosis; Li | 1978 |
Effects of aging and liver disease on disposition of lorazepam.
Topics: Acute Disease; Adult; Aging; Anti-Anxiety Agents; Female; Hepatitis, Viral, Human; Humans; Kinetics; | 1978 |
Effects of liver disease and of aging on the disposition and elimination of sedatives.
Topics: Aging; Anti-Anxiety Agents; Chlordiazepoxide; Chlorpromazine; Diazepam; Half-Life; Hepatitis, Viral, | 1978 |
The effects of liver disease and aging on the disposition of diazepam, chlordiazepoxide, oxazepam and lorazepam in man.
Topics: Administration, Oral; Adult; Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Female; H | 1978 |
Lorazepam kinetics in the elderly.
Topics: Absorption; Administration, Oral; Adult; Aged; Aging; Anti-Anxiety Agents; Female; Half-Life; Humans | 1979 |
Modification of gamma-aminobutyric acidA receptor binding and function by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in vitro and in vivo: effects of aging.
Topics: Aging; Animals; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; | 1991 |