lorazepam has been researched along with Aggression in 43 studies
Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine whether haloperidol plus promethazine is an effective treatment for psychosis-induced aggression." | 8.93 | Haloperidol plus promethazine for psychosis-induced aggression. ( Alexander, J; Allen, MH; Gandhi, P; Huf, G, 2016) |
| "Haloperidol, used alone is recommended to help calm situations of aggression with people with psychosis." | 8.88 | Haloperidol for psychosis-induced aggression or agitation (rapid tranquillisation). ( Adams, CE; Jones, H; Powney, MJ, 2012) |
| "To examine whether haloperidol plus promethazine is an effective treatment for psychosis induced agitation/aggression." | 8.85 | Haloperidol plus promethazine for psychosis-induced aggression. ( Alexander, J; Allen, MH; Huf, G; Raveendran, NS, 2009) |
| "To examine whether haloperidol plus promethazine is an effective treatment for psychosis induced agitation/aggression." | 8.82 | Haloperidol plus promethazine for psychosis induced aggression. ( Alexander, J; Allen, MH; Huf, G, 2005) |
| "We now present data from a randomized, double-blind clinical study of lorazepam versus haloperidol in 20 hospitalized patients with a DSM-III-R diagnosis of bipolar disorder who were being treated concomitantly with lithium." | 5.07 | Adjunctive treatment of manic agitation with lorazepam versus haloperidol: a double-blind study. ( Creelman, WL; Lenox, RH; Newhouse, PA; Whitaker, TM, 1992) |
| "In a double-blind, prospective study, 2 mg of intramuscular lorazepam and 5 mg of intramuscular haloperidol were equally effective in controlling aggression, agitation, and assaultive behavior." | 5.07 | Parenteral lorazepam versus parenteral haloperidol for the control of psychotic disruptive behavior. ( Flowers, E; Glassman, R; Miyawaki, E; Rood, L; Salzman, C; Solomon, D; Thayer, S, 1991) |
| "Two doses of two very similar benzodiazepines (oxazepam 15 and 30 mg: lorazepam 1 and 2 mg) and placebo were compared 4 h post-administration on a competitive reaction time task designed to measure behavioural aggression." | 5.06 | Differential effects of oxazepam and lorazepam on aggressive responding. ( Bond, A; Lader, M, 1988) |
| "To examine whether haloperidol plus promethazine is an effective treatment for psychosis-induced aggression." | 4.93 | Haloperidol plus promethazine for psychosis-induced aggression. ( Alexander, J; Allen, MH; Gandhi, P; Huf, G, 2016) |
| "Haloperidol, used alone is recommended to help calm situations of aggression with people with psychosis." | 4.88 | Haloperidol for psychosis-induced aggression or agitation (rapid tranquillisation). ( Adams, CE; Jones, H; Powney, MJ, 2012) |
| "Haloperidol in combination with promethazine, and olanzapine, are effective in psychotic agitation, although haloperidol plus promethazine has a more rapid onset of effect faster; lorazepam is effective in non-psychotic agitation, aggression or excitement as well as in acute agitation of unknown origin." | 4.87 | [Rapid tranquillisation; review of the literature and recommendations]. ( Bak, M; Marcelis, M; van Os, J, 2011) |
| "To examine whether haloperidol plus promethazine is an effective treatment for psychosis induced agitation/aggression." | 4.85 | Haloperidol plus promethazine for psychosis-induced aggression. ( Alexander, J; Allen, MH; Huf, G; Raveendran, NS, 2009) |
| "To examine whether haloperidol plus promethazine is an effective treatment for psychosis induced agitation/aggression." | 4.82 | Haloperidol plus promethazine for psychosis induced aggression. ( Alexander, J; Allen, MH; Huf, G, 2005) |
| "Sodium phenobarbitone (20 and 70 mg/kg) had a significant anticonvulsant action against pentylenetetrazole-induced seizures, which persisted for 21 days of treatment." | 3.68 | Changes in seizure threshold and aggression during chronic treatment with three anticonvulsants and on drug withdrawal. ( File, SE; Wilks, LJ, 1990) |
| "Lorazepam was administered to all of the patients assigned to risperidone and to 89% of those assigned to zuclopenthixol." | 2.71 | Oral risperidone with lorazepam versus oral zuclopenthixol with lorazepam in the treatment of acute psychosis in emergency psychiatry: a prospective, comparative, open-label study. ( Dries, PJ; Hovens, JE; Loonen, AJ; Melman, CT; Wapenaar, RJ, 2005) |
| "When haloperidol and midazolam were compared with olanzapine, there was some evidence the combination was superior in terms of improvement, sedation and behaviour." | 2.49 | Benzodiazepines for psychosis-induced aggression or agitation. ( Beck, A; Gillies, D; Rathbone, J; Sampson, S, 2013) |
| "Bilateral intraocular pressures were monitored before and after the first 7 ECTs and intermittently after ECT for 10 months of maintenance ECT." | 1.40 | Stability of intraocular pressure after retinal reattachment surgery during electroconvulsive therapy for intractable self-injury in a 12-year-old autistic boy. ( Reti, IM; Wachtel, LE; Ying, H, 2014) |
| "Psychosis and auditory hallucinations are characteristic features of schizophrenia, but may also complicate many somatic diseases." | 1.34 | A vanishing lesion in the temporal lobe associated with schizophrenialike psychosis and catatonia. ( Beerepoot, LJ; Kho, KH; Sommer, IE; van Veelen, NM, 2007) |
| "Diphenhydramine was administered orally in the dose schedules of once daily (10, 20 and 40 mg/kg) and twice daily (5, 10 and 20 mg/kg) in separate groups during the withdrawal period." | 1.30 | Evaluation of inhibitory effect of diphenhydramine on benzodiazepine dependence in rats. ( Gupta, MB; Nath, C; Patnaik, GK; Saxena, RC, 1997) |
| "Audiogenic seizures were completely blocked by 20 mg/kg dose of verapamil and nimodipine while nifedipine was partially effective." | 1.29 | Effect of calcium channel blockers on withdrawal syndrome of lorazepam in rats. ( Gupta, MB; Nath, C; Patnaik, GK; Saxena, RC, 1996) |
| "Ethyl loflazepate was more potent than diazepam, nitrazepam and lorazepam in preventing pentetrazol-induced convulsion." | 1.27 | [Behavioral effects of ethyl loflazepate and its metabolites]. ( Ikeda, K; Kiyota, Y; Ohta, H; Sato, Y; Shibata, K; Shibata, S; Ueki, S; Watanabe, S; Yamamoto, T, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (13.95) | 18.7374 |
| 1990's | 13 (30.23) | 18.2507 |
| 2000's | 9 (20.93) | 29.6817 |
| 2010's | 13 (30.23) | 24.3611 |
| 2020's | 2 (4.65) | 2.80 |
| Authors | Studies |
|---|---|
| Young, G | 1 |
| Tolla, AS | 1 |
| Grinenko, O | 1 |
| Karanec, K | 1 |
| Marouda, K | 1 |
| Mantonakis, L | 1 |
| Kollias, K | 1 |
| Reddy, MSS | 1 |
| Achary, U | 1 |
| Harbishettar, V | 1 |
| Sivakumar, PT | 1 |
| Varghese, M | 1 |
| Bak, M | 2 |
| Weltens, I | 1 |
| Bervoets, C | 1 |
| De Fruyt, J | 1 |
| Samochowiec, J | 1 |
| Fiorillo, A | 1 |
| Sampogna, G | 1 |
| Bienkowski, P | 1 |
| Preuss, WU | 1 |
| Misiak, B | 1 |
| Frydecka, D | 1 |
| Samochowiec, A | 1 |
| Bak, E | 1 |
| Drukker, M | 1 |
| Dom, G | 1 |
| Gillies, D | 1 |
| Sampson, S | 1 |
| Beck, A | 1 |
| Rathbone, J | 1 |
| Mijderwijk, H | 1 |
| van Beek, S | 1 |
| Klimek, M | 1 |
| Duivenvoorden, HJ | 1 |
| Grüne, F | 1 |
| Stolker, RJ | 1 |
| Wachtel, LE | 1 |
| Reti, IM | 1 |
| Ying, H | 1 |
| Barnhorst, A | 1 |
| Xiong, GL | 1 |
| Martin, KM | 1 |
| Huf, G | 3 |
| Alexander, J | 3 |
| Gandhi, P | 1 |
| Allen, MH | 3 |
| Raveendran, NS | 1 |
| Birmingham, C | 1 |
| Ban, K | 1 |
| Rosen, P | 1 |
| Wolfe, R | 1 |
| Davis, D | 1 |
| Sakles, J | 1 |
| Bramwell, K | 1 |
| Sanchez, LD | 1 |
| Zeller, SL | 1 |
| Rhoades, RW | 1 |
| Swart, GT | 1 |
| Siman, E | 1 |
| Stewart, SL | 1 |
| van Os, J | 1 |
| Marcelis, M | 1 |
| Powney, MJ | 1 |
| Adams, CE | 1 |
| Jones, H | 1 |
| Coffey, B | 1 |
| Lejeune, J | 1 |
| Larmo, I | 1 |
| Chrzanowski, W | 1 |
| Witte, R | 1 |
| Karavatos, A | 1 |
| Schreiner, A | 1 |
| Lex, A | 1 |
| Medori, R | 1 |
| Hovens, JE | 1 |
| Dries, PJ | 1 |
| Melman, CT | 1 |
| Wapenaar, RJ | 1 |
| Loonen, AJ | 1 |
| Belgamwar, RB | 1 |
| Fenton, M | 1 |
| Pietras, CJ | 1 |
| Lieving, LM | 1 |
| Cherek, DR | 1 |
| Lane, SD | 1 |
| Tcheremissine, OV | 1 |
| Nouvion, S | 1 |
| Kho, KH | 1 |
| van Veelen, NM | 1 |
| Beerepoot, LJ | 1 |
| Sommer, IE | 1 |
| Kostowski, W | 1 |
| Płaźnik, A | 1 |
| Puciłowski, O | 1 |
| Trzaskowska, E | 1 |
| Lipińska, T | 1 |
| Ueki, S | 1 |
| Watanabe, S | 1 |
| Yamamoto, T | 1 |
| Shibata, S | 1 |
| Shibata, K | 1 |
| Ohta, H | 1 |
| Ikeda, K | 1 |
| Kiyota, Y | 1 |
| Sato, Y | 1 |
| Marcus, A | 1 |
| Ammermann, C | 1 |
| Bahro, M | 1 |
| Schmidt, MH | 1 |
| Gupta, MB | 3 |
| Nath, C | 3 |
| Patnaik, GK | 2 |
| Saxena, RC | 3 |
| Schino, G | 1 |
| Perretta, G | 1 |
| Taglioni, AM | 1 |
| Monaco, V | 1 |
| Troisi, A | 1 |
| Hughes, DH | 1 |
| Gluckman, MI | 1 |
| Stein, L | 1 |
| Lenox, RH | 1 |
| Newhouse, PA | 1 |
| Creelman, WL | 1 |
| Whitaker, TM | 1 |
| Salzman, C | 2 |
| Solomon, D | 1 |
| Miyawaki, E | 1 |
| Glassman, R | 1 |
| Rood, L | 1 |
| Flowers, E | 1 |
| Thayer, S | 1 |
| Little, JD | 1 |
| Taghavi, EH | 1 |
| Krsiak, M | 1 |
| Sulcova, A | 1 |
| Yudofsky, SC | 1 |
| Silver, JM | 1 |
| Hales, RE | 1 |
| Allison, DB | 1 |
| Basile, VC | 1 |
| MacDonald, RB | 1 |
| File, SE | 1 |
| Wilks, LJ | 1 |
| Fritz, J | 1 |
| Stewart, JT | 1 |
| Bond, A | 1 |
| Lader, M | 1 |
| Ward, ME | 1 |
| Saklad, SR | 1 |
| Ereshefsky, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Resistance Under the Microscope; a Randomized Placebo Controlled Parallel Group Design[NCT01441843] | Phase 4 | 400 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| Comparison of Oral Risperdal in Combination With Oral Lorazepam vs Standard Care Including Initial Conventional Neuroleptic IM Treatment, in Acute Schizophrenic Patients[NCT00249171] | Phase 4 | 226 participants (Actual) | Interventional | 2001-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The Quality of Recovery Score - 40 (QoR-40), a 40-item scale, is used to assess the quality of recovery.~Each item is rated on a five-point Likert scale (1-5), and the QoR-40 score is calculated as the sum of the scores on these items. Minimal possible score = 40, maximal possible score = 200. A higher score indicates a higher level of quality of recovery." (NCT01441843)
Timeframe: Baseline; first postoperative working day; seventh postoperative day.
| Intervention | scores on a scale (Mean) | ||
|---|---|---|---|
| Seventh postoperative day | First postoperative working day | Baseline | |
| Lorazepam | 172.8 | 174.5 | 177.2 |
| NaCl 0.9% | 176.3 | 176.4 | 180.4 |
12 reviews available for lorazepam and Aggression
| Article | Year |
|---|---|
The pharmacological management of agitated and aggressive behaviour: A systematic review and meta-analysis.
Topics: Aggression; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Drug Therapy, Combination; H | 2019 |
Benzodiazepines for psychosis-induced aggression or agitation.
Topics: Acute Disease; Aggression; Anti-Dyskinesia Agents; Antipsychotic Agents; Benzodiazepines; Drug Thera | 2013 |
Haloperidol plus promethazine for psychosis-induced aggression.
Topics: Aggression; Benzodiazepines; Drug Therapy, Combination; Haloperidol; Humans; Lorazepam; Midazolam; P | 2016 |
Haloperidol plus promethazine for psychosis-induced aggression.
Topics: Aggression; Benzodiazepines; Drug Therapy, Combination; Haloperidol; Humans; Lorazepam; Midazolam; O | 2009 |
Systematic reviews of assessment measures and pharmacologic treatments for agitation.
Topics: Aggression; Anti-Anxiety Agents; Antipsychotic Agents; Clinical Trials as Topic; Humans; Lorazepam; | 2010 |
[Rapid tranquillisation; review of the literature and recommendations].
Topics: Aggression; Benzodiazepines; Conscious Sedation; Drug Therapy, Combination; Haloperidol; Humans; Hyp | 2011 |
Haloperidol for psychosis-induced aggression or agitation (rapid tranquillisation).
Topics: Aggression; Antipsychotic Agents; Aripiprazole; Clopenthixol; Dystonia; Haloperidol; Humans; Lorazep | 2012 |
Haloperidol plus promethazine for psychosis induced aggression.
Topics: Aggression; Drug Therapy, Combination; Haloperidol; Humans; Lorazepam; Midazolam; Promethazine; Psyc | 2005 |
Olanzapine IM or velotab for acutely disturbed/agitated people with suspected serious mental illnesses.
Topics: Aggression; Antipsychotic Agents; Benzodiazepines; Haloperidol; Humans; Injections, Intramuscular; L | 2005 |
Acute psychopharmacological management of the aggressive psychotic patient.
Topics: Acute Disease; Aggression; Antipsychotic Agents; Dose-Response Relationship, Drug; Haloperidol; Huma | 1999 |
Pharmacologic management of aggression in the elderly.
Topics: Aged; Aggression; Antipsychotic Agents; Benzodiazepines; Buspirone; Dementia; Haloperidol; Humans; L | 1990 |
Use of benzodiazepines to control disruptive behavior in inpatients.
Topics: Aggression; Benzodiazepines; Haloperidol; Hospitalization; Humans; Injections, Intramuscular; Loraze | 1988 |
7 trials available for lorazepam and Aggression
| Article | Year |
|---|---|
Lorazepam does not improve the quality of recovery in day-case surgery patients: a randomised placebo-controlled clinical trial.
Topics: Adult; Aggression; Ambulatory Surgical Procedures; Anti-Anxiety Agents; Anxiety; Double-Blind Method | 2013 |
Oral risperidone plus oral lorazepam versus standard care with intramuscular conventional neuroleptics in the initial phase of treating individuals with acute psychosis.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Aggression; Antipsy | 2004 |
Oral risperidone with lorazepam versus oral zuclopenthixol with lorazepam in the treatment of acute psychosis in emergency psychiatry: a prospective, comparative, open-label study.
Topics: Adolescent; Adult; Aged; Aggression; Anti-Anxiety Agents; Antipsychotic Agents; Clopenthixol; Drug T | 2005 |
Acute effects of lorazepam on laboratory measures of aggressive and escape responses of adult male parolees.
Topics: Adult; Aggression; Anti-Anxiety Agents; Criminal Psychology; Dose-Response Relationship, Drug; Human | 2005 |
Adjunctive treatment of manic agitation with lorazepam versus haloperidol: a double-blind study.
Topics: Adult; Aged; Aggression; Bipolar Disorder; Double-Blind Method; Drug Therapy, Combination; Female; H | 1992 |
Parenteral lorazepam versus parenteral haloperidol for the control of psychotic disruptive behavior.
Topics: Acute Disease; Adult; Aggression; Antipsychotic Agents; Double-Blind Method; Drug Therapy, Combinati | 1991 |
Differential effects of oxazepam and lorazepam on aggressive responding.
Topics: Adult; Aggression; Anxiety; Emotions; Female; Humans; Lorazepam; Male; Middle Aged; Oxazepam; Reacti | 1988 |
24 other studies available for lorazepam and Aggression
| Article | Year |
|---|---|
Neuropsychiatric manifestations in adult-onset Still's disease.
Topics: Aggression; Anticonvulsants; Arthralgia; Diagnosis, Differential; Electroencephalography; Female; Fe | 2020 |
Brief psychotic disorder with delusion content related to the COVID-19 outbreak.
Topics: Adult; Aggression; Anti-Anxiety Agents; Antipsychotic Agents; COVID-19; Delusions; Humans; Involunta | 2021 |
Paradoxical reaction to benzodiazepines in elderly - Case series.
Topics: Aged; Aggression; Benzodiazepines; Clonazepam; GABA Modulators; Humans; Lorazepam; Male; Psychomotor | 2018 |
Stability of intraocular pressure after retinal reattachment surgery during electroconvulsive therapy for intractable self-injury in a 12-year-old autistic boy.
Topics: Aggression; Anticonvulsants; Antipsychotic Agents; Autistic Disorder; Child; Electroconvulsive Thera | 2014 |
Pulmonary embolism in a psychiatric patient.
Topics: Adult; Aggression; Antipsychotic Agents; Autopsy; Benzodiazepines; Bipolar Disorder; Catatonia; Deat | 2014 |
Animal Behavior Case of the Month. Reactional urine marking.
Topics: Aggression; Animals; Anti-Anxiety Agents; Cats; Eliminative Behavior, Animal; Female; Fluoxetine; Lo | 2015 |
An intoxicated man with facial trauma.
Topics: Aggression; Alcoholic Intoxication; Anti-Anxiety Agents; Antipsychotic Agents; Emergency Medical Ser | 2010 |
The use of Pro Re Nata or Statim medications for behavioral control: a summary of experience at a tertiary care children's mental health center.
Topics: Adolescent; Age Factors; Aggression; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Chi | 2011 |
Clinical case presentation: therapeutic challenges in adolescent-onset bipolar disorder.
Topics: Adolescent; Aggression; Anti-Anxiety Agents; Antimanic Agents; Antipsychotic Agents; Bipolar Disorde | 2003 |
A vanishing lesion in the temporal lobe associated with schizophrenialike psychosis and catatonia.
Topics: Adult; Aggression; Antipsychotic Agents; Brain Diseases; Catatonia; Delusions; Diffusion Magnetic Re | 2007 |
Some behavioral effects of chlorodesmethyldiazepam and lorazepam.
Topics: Acoustic Stimulation; Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; D | 1981 |
[Behavioral effects of ethyl loflazepate and its metabolites].
Topics: Aggression; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Benzod | 1983 |
Benzodiazepine administration induces exogenic psychosis: a case of child abuse.
Topics: Aggression; Anti-Anxiety Agents; Benzodiazepines; Child; Child Abuse; Child Welfare; Humans; Lorazep | 1995 |
Effect of calcium channel blockers on withdrawal syndrome of lorazepam in rats.
Topics: Acoustic Stimulation; Aggression; Animals; Body Temperature; Calcium Channel Blockers; Female; Loraz | 1996 |
Primate displacement activities as an ethopharmacological model of anxiety.
Topics: Aggression; Animals; Anti-Anxiety Agents; Arousal; Behavior, Animal; Carbolines; Displacement, Psych | 1996 |
Evaluation of inhibitory effect of diphenhydramine on benzodiazepine dependence in rats.
Topics: Acoustic Stimulation; Administration, Oral; Aggression; Animals; Anti-Anxiety Agents; Body Temperatu | 1997 |
Effect of dopamine agonists and antagonists on the lorazepam withdrawal syndrome in rats.
Topics: Acoustic Stimulation; Aggression; Animals; Anti-Anxiety Agents; Dopamine Agonists; Dopamine Antagoni | 2000 |
Pharmacology of lorazepam.
Topics: Aggression; Animals; Anti-Anxiety Agents; Avoidance Learning; Behavior, Animal; Cats; Conditioning, | 1978 |
Disinhibition after lorazepam augmentation of antipsychotic medication.
Topics: Adult; Aggression; Antipsychotic Agents; Dose-Response Relationship, Drug; Drug Therapy, Combination | 1991 |
Differential effects of six structurally related benzodiazepines on some ethological measures of timidity, aggression and locomotion in mice.
Topics: Aggression; Alprazolam; Animals; Anti-Anxiety Agents; Behavior, Animal; Clonazepam; Lorazepam; Male; | 1990 |
Brief report: comparative effects of antecedent exercise and lorazepam on the aggressive behavior of an autistic man.
Topics: Adult; Aggression; Autistic Disorder; Combined Modality Therapy; Exercise; Humans; Lorazepam; Male; | 1991 |
Changes in seizure threshold and aggression during chronic treatment with three anticonvulsants and on drug withdrawal.
Topics: Aggression; Animals; Anticonvulsants; Lorazepam; Male; Mice; Pentylenetetrazole; Phenobarbital; Phen | 1990 |
Lorazepam treatment of resistive aggression in dementia.
Topics: Aged; Aged, 80 and over; Aggression; Dementia; Dementia, Multi-Infarct; Humans; Lorazepam; Male | 1990 |
Lorazepam for the treatment of psychotic agitation.
Topics: Adult; Aggression; Humans; Injections, Intramuscular; Lorazepam; Male; Psychomotor Agitation; Schizo | 1986 |