lorazepam has been researched along with Acute Hypercapnic Respiratory Failure in 20 studies
Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lorazepam was compared with diazepam for the treatment of acute convulsions and status epilepticus in 102 children in a prospective, open, 'odd and even dates' trial." | 9.08 | Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus. ( Appleton, R; Choonara, I; Molyneux, E; Robson, J; Sweeney, A, 1995) |
| "Hypoxic and non-hypoxic patients showed no significant paCO(2) increase or SaO(2) decrease after opioid application in combination with lorazepam." | 6.76 | Dyspnoea associated with anxiety--symptomatic therapy with opioids in combination with lorazepam and its effect on ventilation in palliative care patients. ( Clemens, KE; Klaschik, E, 2011) |
| "Lorazepam was compared with diazepam for the treatment of acute convulsions and status epilepticus in 102 children in a prospective, open, 'odd and even dates' trial." | 5.08 | Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus. ( Appleton, R; Choonara, I; Molyneux, E; Robson, J; Sweeney, A, 1995) |
| "To evaluate a protocol based on continuous infusion of a benzodiazepine and morphine to produce apnea/decreased respiratory effort as an adjunct to complex mechanical ventilation in patients with respiratory failure." | 3.69 | A method to produce sedation in critically ill patients. ( Johnson, M; Watling, SM; Yanos, J, 1996) |
| "Hypoxic and non-hypoxic patients showed no significant paCO(2) increase or SaO(2) decrease after opioid application in combination with lorazepam." | 2.76 | Dyspnoea associated with anxiety--symptomatic therapy with opioids in combination with lorazepam and its effect on ventilation in palliative care patients. ( Clemens, KE; Klaschik, E, 2011) |
| " We characterized the distribution of infant characteristics and evaluated the relationship between drug administration and any adverse event." | 1.56 | Comparative safety profile of chloral hydrate versus other sedatives for procedural sedation in hospitalized infants. ( Balevic, S; Chu, V; Clark, R; Crenshaw, EG; Dallefeld, SH; Daniel, KR; Gilleskie, ML; Greenberg, RG; Kumar, KR; Smith, DS; Smith, PB; Zimmerman, KO, 2020) |
| "The incidence of coma was significantly higher, and the length of hospital stay significantly longer in elderly." | 1.43 | Benzodiazepine poisoning in elderly. ( Djordjević, S; Ercegović, GV; Segrt, Z; Stosić, JJ; Vukcević, NP, 2016) |
| "Fourteen days after the seizure, the patient returned for follow-up magnetic resonance imaging of the brain and head with gadolinium contrast." | 1.38 | Seizure activity during cetuximab infusion in a patient with metastatic colorectal cancer. ( Bell, WA; McClellan, NH, 2012) |
| " A reduction in the dosage of benzodiazepines in the setting of epileptic patients with predominant autonomic symptoms may need to be considered." | 1.37 | Benzodiazepines in the acute management of seizures with autonomic manifestations: anticipate complications! ( Fluss, J; Gervaix, A; Korff, CM; Lacroix, L, 2011) |
| " Naloxone 2 mg by gastric tube every 8 hours for 8 days was started; the dosage then was increased to 4 mg every 8 hours." | 1.32 | Enteral administration of naloxone for treatment of opioid-associated intragastric feeding intolerance. ( Bloom, K; Liebl, MG; Mixides, G, 2004) |
| "The incidence of respiratory depression following treatment of prolonged seizures with benzodiazepines is variable in the literature." | 1.31 | Respiratory depression in the acute management of seizures. ( Dooley, JM; Harrison, R; Stewart, WA, 2002) |
| "In critically ill patients in respiratory failure, neuromuscular paralysis decreased whole body oxygen consumption and increased pHi." | 1.29 | The effects of neuromuscular paralysis on systemic and splanchnic oxygen utilization in mechanically ventilated patients. ( Kaufman, D; Marik, PE, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 4 (20.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 8 (40.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dallefeld, SH | 1 |
| Smith, PB | 1 |
| Crenshaw, EG | 1 |
| Daniel, KR | 1 |
| Gilleskie, ML | 1 |
| Smith, DS | 1 |
| Balevic, S | 1 |
| Greenberg, RG | 1 |
| Chu, V | 1 |
| Clark, R | 1 |
| Kumar, KR | 1 |
| Zimmerman, KO | 1 |
| Lopez, E | 1 |
| Fraile, S | 1 |
| Hidalgo, FJ | 1 |
| García, B | 1 |
| Vukcević, NP | 1 |
| Ercegović, GV | 1 |
| Segrt, Z | 1 |
| Djordjević, S | 1 |
| Stosić, JJ | 1 |
| Clemens, KE | 1 |
| Klaschik, E | 1 |
| Martin, HA | 1 |
| Lacroix, L | 1 |
| Fluss, J | 1 |
| Gervaix, A | 1 |
| Korff, CM | 1 |
| da Silva, PS | 1 |
| Passos, RM | 1 |
| Waisberg, DR | 1 |
| Yuan, W | 1 |
| Williams, BN | 1 |
| McClellan, NH | 1 |
| Bell, WA | 1 |
| Stewart, WA | 1 |
| Harrison, R | 1 |
| Dooley, JM | 1 |
| Izurieta, R | 1 |
| Rabatin, JT | 1 |
| Mixides, G | 1 |
| Liebl, MG | 1 |
| Bloom, K | 1 |
| Jäger, U | 1 |
| Hruby, K | 1 |
| Haubenstock, A | 1 |
| Fasching, I | 1 |
| Appleton, R | 1 |
| Sweeney, A | 1 |
| Choonara, I | 1 |
| Robson, J | 1 |
| Molyneux, E | 1 |
| Klimke, A | 1 |
| Klieser, E | 1 |
| Marik, PE | 1 |
| Kaufman, D | 1 |
| Watling, SM | 1 |
| Johnson, M | 1 |
| Yanos, J | 1 |
| Arbour, R | 1 |
| Esparis, B | 1 |
| Tayar, J | 1 |
| Jabbour, G | 1 |
| Saggi, SJ | 1 |
| Cohen, S | 1 |
| Khan, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, Randomized Trial of Enteral Naloxone Versus a Traditional Bowel Regimen in Prevention of Constipation and Decreased Gastric Motility in Critically Ill Trauma Patients[NCT00799201] | Phase 4 | 3 participants (Actual) | Interventional | 2007-08-31 | Terminated (stopped due to Naloxone became unavailable due to manufacturing shortatges requiring the study to be terminated.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for lorazepam and Acute Hypercapnic Respiratory Failure
| Article | Year |
|---|---|
Sedation during mechanical ventilation: a systematic review.
Topics: Adult; Anesthetics; Humans; Hypnotics and Sedatives; Intensive Care Units; Lorazepam; Midazolam; Pro | 2002 |
2 trials available for lorazepam and Acute Hypercapnic Respiratory Failure
| Article | Year |
|---|---|
Dyspnoea associated with anxiety--symptomatic therapy with opioids in combination with lorazepam and its effect on ventilation in palliative care patients.
Topics: Aged; Analgesics, Opioid; Anxiety; Drug Interactions; Dyspnea; Female; Germany; Humans; Hypnotics an | 2011 |
Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus.
Topics: Administration, Rectal; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Injections, Intravenou | 1995 |
17 other studies available for lorazepam and Acute Hypercapnic Respiratory Failure
| Article | Year |
|---|---|
Comparative safety profile of chloral hydrate versus other sedatives for procedural sedation in hospitalized infants.
Topics: Chloral Hydrate; Diagnostic Imaging; Diagnostic Techniques, Ophthalmological; Electroencephalography | 2020 |
[Possible malignant neuroleptic syndrome associated with aripiprazole and imipramine and treated with bromocriptine].
Topics: Antipsychotic Agents; Aripiprazole; Bromocriptine; Combined Modality Therapy; Drug Therapy, Combinat | 2013 |
Benzodiazepine poisoning in elderly.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antidotes; Benzodiazepines; Bromazepam; Coh | 2016 |
The possible consequences of combining Lorazepam and buprenorphine/naloxone: a case review.
Topics: Adult; Anti-Anxiety Agents; Buprenorphine; Drug Interactions; Female; Humans; Intubation, Intratrach | 2011 |
Benzodiazepines in the acute management of seizures with autonomic manifestations: anticipate complications!
Topics: Autonomic Nervous System Diseases; Benzodiazepines; Child; Child, Preschool; Diazepam; Female; Human | 2011 |
Withdrawal treatment with clonidine after prolonged use of chloral hydrate in a pediatric intensive care patient.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Chloral Hydrate; Clonidine; Fentanyl; Humans; Hypnoti | 2011 |
Interactions among benzodiazepine and buprenorphine/naloxone.
Topics: Anti-Anxiety Agents; Buprenorphine; Female; Humans; Lorazepam; Naloxone; Narcotic Antagonists; Respi | 2012 |
Seizure activity during cetuximab infusion in a patient with metastatic colorectal cancer.
Topics: Antibodies, Monoclonal, Humanized; Anticonvulsants; Antineoplastic Agents; Cetuximab; Colorectal Neo | 2012 |
Respiratory depression in the acute management of seizures.
Topics: Anticonvulsants; Child; Child, Preschool; Chronic Disease; Diazepam; Drug Therapy, Combination; Huma | 2002 |
Enteral administration of naloxone for treatment of opioid-associated intragastric feeding intolerance.
Topics: Adult; Catheters, Indwelling; Cross Infection; Drug Administration Schedule; Enteral Nutrition; Fata | 2004 |
[Comparative clinical toxicology of 5 benzodiazepine derivatives].
Topics: Adult; Anti-Anxiety Agents; Bromazepam; Child; Coma; Diazepam; Dose-Response Relationship, Drug; Fem | 1984 |
Sudden death after intravenous application of lorazepam in a patient treated with clozapine.
Topics: Adult; Clozapine; Death, Sudden; Drug Interactions; Drug Therapy, Combination; Humans; Injections, I | 1994 |
The effects of neuromuscular paralysis on systemic and splanchnic oxygen utilization in mechanically ventilated patients.
Topics: Aged; Analgesics, Opioid; APACHE; Carbon Dioxide; Cardiac Output; Critical Illness; Female; Hemodyna | 1996 |
A method to produce sedation in critically ill patients.
Topics: Adolescent; Adult; Analgesics, Opioid; Anti-Anxiety Agents; APACHE; Apnea; Child; Conscious Sedation | 1996 |
Osmolar gap metabolic acidosis in a 60-year-old man treated for hypoxemic respiratory failure.
Topics: Acidosis, Lactic; Drug Combinations; Humans; Hypnotics and Sedatives; Hypoxia; Infusions, Intravenou | 2000 |
Severe hyperosmolar metabolic acidosis due to a large dose of intravenous lorazepam.
Topics: Acidosis; Adult; Female; Humans; Infusions, Intravenous; Lorazepam; Osmolar Concentration; Oxidation | 2002 |
Respiratory distress with use of lorazepam in mania.
Topics: Adult; Bipolar Disorder; Female; Humans; Lorazepam; Respiratory Insufficiency | 1987 |