lorazepam has been researched along with Absence Seizure in 139 studies
Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intravenous lorazepam is considered the drug of first choice for control of acute convulsive seizures." | 9.15 | Intranasal versus intravenous lorazepam for control of acute seizures in children: a randomized open-label study. ( Arya, R; Gulati, S; Kabra, M; Kalra, V; Sahu, JK, 2011) |
| ") lorazepam (LZP) in children with severe malaria and convulsions." | 9.13 | Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and convulsions. ( Edwards, G; Kokwaro, GO; Muchohi, SN; Newton, CR; Obiero, K; Ogutu, BR, 2008) |
| "Treatment with intravenous lorazepam is associated with a significant reduction in the risk of recurrent seizures related to alcohol." | 9.09 | Lorazepam for the prevention of recurrent seizures related to alcohol. ( D'Onofrio, G; Fish, SS; Freedland, ES; Rathlev, NK; Ulrich, AS, 1999) |
| "Lorazepam was compared with diazepam for the treatment of acute convulsions and status epilepticus in 102 children in a prospective, open, 'odd and even dates' trial." | 9.08 | Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus. ( Appleton, R; Choonara, I; Molyneux, E; Robson, J; Sweeney, A, 1995) |
| "Some guidelines or expert consensus indicate that intravenous (IV) lorazepam (LZP) is preferable to IV diazepam (DZP) for initial treatment of convulsive status epilepticus (SE)." | 8.93 | Is intravenous lorazepam really more effective and safe than intravenous diazepam as first-line treatment for convulsive status epilepticus? A systematic review with meta-analysis of randomized controlled trials. ( Bacigaluppi, S; Bragazzi, NL; Brigo, F; Nardone, R; Trinka, E, 2016) |
| "A short-cut review was carried out to determine whether intranasal lorazepam was as effective as intravenous lorazepam in the control of seizures in children." | 8.89 | Best BETs from the Manchester Royal Infirmary. BET 1: intranasal lorazepam is an acceptable alternative to intravenous lorazepam in the control of acute seizures in children. ( Allan, A; Cullen, J, 2013) |
| "High-dose IA verapamil treatment is well-tolerated in the high-risk aneurysmal subarachnoid hemorrhage population that experience severe, symptomatic CVS with good functional outcomes at follow-up." | 8.02 | The clinical impact and safety profile of high-dose intra-arterial verapamil treatment for cerebral vasospasm following aneurysmal subarachnoid hemorrhage. ( Esplin, N; Gigliotti, MJ; Mao, G; Sexton, K, 2021) |
| "The objective of the study was to compare the performance of intravenous (IV) lorazepam (IVL) and intranasal midazolam (INM) for seizure termination and prevention of seizure clusters in adults admitted to the epilepsy monitoring unit (EMU) in whom seizures were captured on continuous video-electroencephalogram." | 7.91 | Comparison of intranasal midazolam versus intravenous lorazepam for seizure termination and prevention of seizure clusters in the adult epilepsy monitoring unit. ( Bautista, C; Cotugno, S; Deng, Y; Dhakar, MB; Farooque, P; Hirsch, LJ; Maciel, CB; McKimmy, D; Owusu, KA; Sukumar, N, 2019) |
| "Eslicarbazepine is a novel anti-epileptic agent indicated for the treatment of partial-onset seizures." | 7.88 | Intentional overdose of the novel anti-epileptic drug eslicarbazepine presenting with recurrent seizures and ventricular dysrhythmias. ( Ovakim, DH; Powell, JD; Thompson, J, 2018) |
| " As a step toward eventual coupling of rTMS with antiepileptic pharmacotherapy, we also tested whether high-frequency rTMS in combination with a low (ineffective but less likely to cause a side effect) lorazepam dose is as effective as a full lorazepam dose in suppressing seizures in a rat SE model." | 7.83 | Bursts of high-frequency repetitive transcranial magnetic stimulation (rTMS), together with lorazepam, suppress seizures in a rat kainate status epilepticus model. ( Dhamne, SC; Gersner, R; Pascual-Leone, A; Rotenberg, A; Zangen, A, 2016) |
| " Citalopram, a newer generation SSRI, is commonly prescribed, but despite its low toxicity profile has a potential to cause seizures and dysarrythmias in overdose." | 7.76 | Metabolic acidosis and generalized seizures secondary to citalopram overdose: a case report. ( Al Anazi, T; Al Hayyan, H; Al Hussein, M; Al Modaimegh, H; Al Qahtani, M; Bin Salih, S, 2010) |
| "Pharmacokinetic data were evaluated in 10 term neonates with seizures after intravenous administration of lorazepam, 0." | 7.68 | Pharmacokinetics of lorazepam in critically ill neonates with seizures. ( Kowalczyk, AL; Mangurten, HH; McDermott, CA; Metrick, S; Rodvold, KA; Schnitzler, ER, 1992) |
| "Seven neonatal patients with severe seizures unresponsive to conventional anticonvulsant therapy were treated with lorazepam." | 7.67 | Lorazepam in the treatment of refractory neonatal seizures. A pilot study. ( Deshmukh, A; Mangurten, HH; Schnitzler, E; Wittert, W, 1986) |
| "We report our experience with 300 consecutive parenteral doses of lorazepam (LOR) for status epilepticus (SE) or serial seizures in 77 children and young adults." | 7.67 | Lorazepam in childhood status epilepticus and serial seizures: effectiveness and tachyphylaxis. ( Crawford, TO; Mitchell, WG; Snodgrass, SR, 1987) |
| "The dose response curves of picrotoxin-induced seizures and pentylenetetrazol-induced seizures were shifted to the right by the benzodiazepine (BZ) receptor agonist lorazepam, and to the left by the inverse agonists, DMCM, ZK 90886, FG 7142 and CGS 8216." | 7.66 | Bidirectional effects of benzodiazepine receptor ligands against picrotoxin- and pentylenetetrazol-induced seizures. ( Jensen, LH; Petersen, EN, 1983) |
| "Primary outcome was seizure cessation for 1h, and secondary outcomes were 24h seizure remission, in-hospital death, and severe adverse events (SAE)." | 6.84 | Comparison of lacosamide versus sodium valproate in status epilepticus: A pilot study. ( Dubey, D; Kalita, J; Misra, UK, 2017) |
| "Status Epilepticus is the most common non-traumatic neurologic emergency in childhood." | 5.72 | Resolution of status epilepticus after ketamine administration. ( Hakmeh, W; Howing, CE; Razi, F, 2022) |
| " The most common adverse events (AEs) were somnolence (7." | 5.51 | [Efficacy and Safety of Lorazepam Intravenously Administered in Subjects with Status Epilepticus or Repetitive Seizures]. ( Nakasato, N; Nakazuru, Y; Ohtsuka, Y; Terada, M, 2019) |
| " lorazepam (LZP) in patients with epilepsy undergoing evaluation in an epilepsy monitoring unit (EMU) who experienced seizures requiring acute treatment." | 5.34 | Randomized open-label trial of intravenous brivaracetam versus lorazepam for acute treatment of increased seizure activity. ( Greve, B; Moseley, BD; Sadek, A; Szaflarski, JP; Varner, JA; Williams, P, 2020) |
| " Determining benzodiazepines that do not produce pharmacodynamic sensitivity, such as lorazepam, may allow more careful prescribing and dosing of these drugs, and perhaps even the development of specific agents which could avoid this sensitivity." | 5.33 | The effect of chronic lorazepam administration in aging mice. ( Fahey, JM; Grassi, JM; Greenblatt, DJ; Pratt, JS; Pritchard, GA; Reddi, JM; Shader, RI, 2006) |
| "Infants with refractory seizures received additional phenobarbital to a maximum serum concentration of 100 micrograms/mL." | 5.28 | Rapid sequential phenobarbital treatment of neonatal seizures. ( Duchowny, MS; Gal, P; Gilman, JT; Ransom, JL; Weaver, RL, 1989) |
| " Head-to-head trials comparing buccal versus intranasal midazolam versus rectal diazepam would provide useful information to inform the management of the first stage of convulsive status epilepticus in adults, especially when intravenous or intramuscular access is not feasible." | 5.22 | Management of the first stage of convulsive status epilepticus in adults: a systematic review of current randomised evidence. ( Aucott, L; Booth, C; Brazzelli, M; Counsell, C; Cruickshank, M; Imamura, M; Manson, P; Scotland, G, 2022) |
| "Intravenous lorazepam is considered the drug of first choice for control of acute convulsive seizures." | 5.15 | Intranasal versus intravenous lorazepam for control of acute seizures in children: a randomized open-label study. ( Arya, R; Gulati, S; Kabra, M; Kalra, V; Sahu, JK, 2011) |
| ") lorazepam (LZP) in children with severe malaria and convulsions." | 5.13 | Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and convulsions. ( Edwards, G; Kokwaro, GO; Muchohi, SN; Newton, CR; Obiero, K; Ogutu, BR, 2008) |
| " 160 children aged over 2 months with seizures persisting for more than 5 min were randomly assigned to receive either intranasal lorazepam (100 microg/kg, n=80) or intramuscular paraldehyde (0." | 5.12 | Efficacy and safety of intranasal lorazepam versus intramuscular paraldehyde for protracted convulsions in children: an open randomised trial. ( Ahmad, S; Ellis, JC; Kamwendo, H; Molyneux, E, 2006) |
| "Treatment with intravenous lorazepam is associated with a significant reduction in the risk of recurrent seizures related to alcohol." | 5.09 | Lorazepam for the prevention of recurrent seizures related to alcohol. ( D'Onofrio, G; Fish, SS; Freedland, ES; Rathlev, NK; Ulrich, AS, 1999) |
| "Lorazepam was compared with diazepam for the treatment of acute convulsions and status epilepticus in 102 children in a prospective, open, 'odd and even dates' trial." | 5.08 | Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus. ( Appleton, R; Choonara, I; Molyneux, E; Robson, J; Sweeney, A, 1995) |
| " This report shows that lorazepam should be taken into consideration (before moving to ECT), in cases of unresolved catatonia, even if the seizures are reduced with anticonvulsants." | 4.98 | Persistent catatonia following epileptic seizures: a case report and systematic literature search. ( Luykx, JJ; Verbraeken, R, 2018) |
| "Some guidelines or expert consensus indicate that intravenous (IV) lorazepam (LZP) is preferable to IV diazepam (DZP) for initial treatment of convulsive status epilepticus (SE)." | 4.93 | Is intravenous lorazepam really more effective and safe than intravenous diazepam as first-line treatment for convulsive status epilepticus? A systematic review with meta-analysis of randomized controlled trials. ( Bacigaluppi, S; Bragazzi, NL; Brigo, F; Nardone, R; Trinka, E, 2016) |
| "A short-cut review was carried out to determine whether intranasal lorazepam was as effective as intravenous lorazepam in the control of seizures in children." | 4.89 | Best BETs from the Manchester Royal Infirmary. BET 1: intranasal lorazepam is an acceptable alternative to intravenous lorazepam in the control of acute seizures in children. ( Allan, A; Cullen, J, 2013) |
| "High-dose IA verapamil treatment is well-tolerated in the high-risk aneurysmal subarachnoid hemorrhage population that experience severe, symptomatic CVS with good functional outcomes at follow-up." | 4.02 | The clinical impact and safety profile of high-dose intra-arterial verapamil treatment for cerebral vasospasm following aneurysmal subarachnoid hemorrhage. ( Esplin, N; Gigliotti, MJ; Mao, G; Sexton, K, 2021) |
| " Our study aims to assess if administering lorazepam, for convulsive seizures <5 min, causes vital instability." | 3.96 | Lorazepam timing for acute convulsive seizure control (LoTASC). ( Gopal, M; Greene-Chandos, D; Hamed, M; Hussein, O; Kamdar, HA; Peters, E; Sawalha, K; Shanmugam, K; Smetana, KS; Thakur, G; Yasin, R, 2020) |
| "The objective of the study was to compare the performance of intravenous (IV) lorazepam (IVL) and intranasal midazolam (INM) for seizure termination and prevention of seizure clusters in adults admitted to the epilepsy monitoring unit (EMU) in whom seizures were captured on continuous video-electroencephalogram." | 3.91 | Comparison of intranasal midazolam versus intravenous lorazepam for seizure termination and prevention of seizure clusters in the adult epilepsy monitoring unit. ( Bautista, C; Cotugno, S; Deng, Y; Dhakar, MB; Farooque, P; Hirsch, LJ; Maciel, CB; McKimmy, D; Owusu, KA; Sukumar, N, 2019) |
| "Eslicarbazepine is a novel anti-epileptic agent indicated for the treatment of partial-onset seizures." | 3.88 | Intentional overdose of the novel anti-epileptic drug eslicarbazepine presenting with recurrent seizures and ventricular dysrhythmias. ( Ovakim, DH; Powell, JD; Thompson, J, 2018) |
| " He had a history of neonatal seizures, had been stabilized with vigabatrin, and was seizure free without treatment for several months." | 3.88 | Catatonia Associated With a ( Amad, A; Corfiotti, C; Ferrafiat, V; Jardri, R; Leroy, A; Medjkane, F; Nguyen The Tich, S, 2018) |
| " As a step toward eventual coupling of rTMS with antiepileptic pharmacotherapy, we also tested whether high-frequency rTMS in combination with a low (ineffective but less likely to cause a side effect) lorazepam dose is as effective as a full lorazepam dose in suppressing seizures in a rat SE model." | 3.83 | Bursts of high-frequency repetitive transcranial magnetic stimulation (rTMS), together with lorazepam, suppress seizures in a rat kainate status epilepticus model. ( Dhamne, SC; Gersner, R; Pascual-Leone, A; Rotenberg, A; Zangen, A, 2016) |
| " Citalopram, a newer generation SSRI, is commonly prescribed, but despite its low toxicity profile has a potential to cause seizures and dysarrythmias in overdose." | 3.76 | Metabolic acidosis and generalized seizures secondary to citalopram overdose: a case report. ( Al Anazi, T; Al Hayyan, H; Al Hussein, M; Al Modaimegh, H; Al Qahtani, M; Bin Salih, S, 2010) |
| "To characterize the potential interaction between the excitatory and inhibitory neurotransmitter systems, the effects of dizocilpine, CPP, and lorazepam on open-field behavior and pentylenetetrazol-induced seizures were evaluated in mice." | 3.70 | Lorazepam attenuates the behavioral effects of dizocilpine. ( Fahey, JM; Greenblatt, DJ; Pratt, JS; Pritchard, GA; Shader, RI, 1999) |
| "In this study, we present five cases of seizures following withdrawal of flunitrazepam, lorazepam, or triazolam, representing 3% of a sample consisting of 153 patients dependent on benzodiazepines." | 3.69 | Benzodiazepine withdrawal syndrome seizures. ( de Iceta, M; Martínez-Cano, H; Martínez-Gras, I; Pomalima, R; Vela-Bueno, A, 1995) |
| "A 15-month-old girl underwent several emergency department (ED) visits and two admissions for parent-reported histories of ingestions, apnea, and seizures." | 3.69 | Clinical and toxicological findings in two young siblings and autopsy findings in one sibling with multiple hospital admissions resulting in death. Evidence suggesting Munchausen syndrome by proxy. ( Jones, JG; Schexnayder, S; Sturner, WQ; Valentine, JL, 1997) |
| "Pharmacokinetic data were evaluated in 10 term neonates with seizures after intravenous administration of lorazepam, 0." | 3.68 | Pharmacokinetics of lorazepam in critically ill neonates with seizures. ( Kowalczyk, AL; Mangurten, HH; McDermott, CA; Metrick, S; Rodvold, KA; Schnitzler, ER, 1992) |
| "Sodium phenobarbitone (20 and 70 mg/kg) had a significant anticonvulsant action against pentylenetetrazole-induced seizures, which persisted for 21 days of treatment." | 3.68 | Changes in seizure threshold and aggression during chronic treatment with three anticonvulsants and on drug withdrawal. ( File, SE; Wilks, LJ, 1990) |
| "The drugs currently used in the emergency management of seizures are chiefly phenytoin, phenobarbital, diazepam, lorazepam, and paraldehyde." | 3.67 | Emergency management of seizures: an overview. ( Uthman, BM; Wilder, BJ, 1989) |
| "Seven neonatal patients with severe seizures unresponsive to conventional anticonvulsant therapy were treated with lorazepam." | 3.67 | Lorazepam in the treatment of refractory neonatal seizures. A pilot study. ( Deshmukh, A; Mangurten, HH; Schnitzler, E; Wittert, W, 1986) |
| "We report our experience with 300 consecutive parenteral doses of lorazepam (LOR) for status epilepticus (SE) or serial seizures in 77 children and young adults." | 3.67 | Lorazepam in childhood status epilepticus and serial seizures: effectiveness and tachyphylaxis. ( Crawford, TO; Mitchell, WG; Snodgrass, SR, 1987) |
| "The dose response curves of picrotoxin-induced seizures and pentylenetetrazol-induced seizures were shifted to the right by the benzodiazepine (BZ) receptor agonist lorazepam, and to the left by the inverse agonists, DMCM, ZK 90886, FG 7142 and CGS 8216." | 3.66 | Bidirectional effects of benzodiazepine receptor ligands against picrotoxin- and pentylenetetrazol-induced seizures. ( Jensen, LH; Petersen, EN, 1983) |
| "Primary outcome was seizure cessation for 1h, and secondary outcomes were 24h seizure remission, in-hospital death, and severe adverse events (SAE)." | 2.84 | Comparison of lacosamide versus sodium valproate in status epilepticus: A pilot study. ( Dubey, D; Kalita, J; Misra, UK, 2017) |
| "Therefore, the acute care of prolonged seizures and SE is a constant challenge for healthcare professionals, in both the pre-hospital and the in-hospital settings." | 2.82 | Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability. ( Beuchat, I; Gelhard, S; Kay, L; Kienitz, R; Lucaciu, A; Mann, C; Rosenow, F; Schäfer, JH; Schubert-Bast, S; Siebenbrodt, K; Strzelczyk, A; von Brauchitsch, S; Willems, LM; Zöllner, JP, 2022) |
| "Diazepam rectal gel is an effective rescue therapy for seizure clusters, though adults and adolescents may have social reservations regarding its administration." | 2.82 | Rescue Treatments for Seizure Clusters. ( Gidal, BE; Kotloski, RJ, 2022) |
| "Sublingual lorazepam stopped seizures within 10 minutes of administration in 56% of children compared with intrarectal diazepam in 79% (P < ." | 2.79 | Efficacy of sublingual lorazepam versus intrarectal diazepam for prolonged convulsions in Sub-Saharan Africa. ( Dubru, JM; Kahamba, DM; Kokolomani, J; Malu, CK; Mayamba, RM; Misson, JP; Mukampunga, C; Musalu, EM; Walker, TD; Wilmshurst, JM, 2014) |
| "Psychogenic nonepileptic seizures (PNES) are commonly encountered problem in neurological practice and usually are accompanied by other psychiatric comorbidities." | 2.78 | The effect of selective serotonin reuptake inhibitors on the frequency of psychogenic nonepileptic seizures: a critically appraised topic. ( Bravo, TP; Demaerschalk, BM; Hoerth, MT; Hoffman-Snyder, CR; Martin, KA; Wellik, KE; Wingerchuk, DM, 2013) |
| "For diazepam group it was 84." | 2.77 | Intravenous diazepam, midazolam and lorazepam in acute seizure control. ( Gathwala, G; Goel, M; Mittal, K; Singh, J, 2012) |
| "Seizure is a recognized complication of high-dose busulfan (BU) therapy and phenytoin (DPH) is widely used as prophylaxis." | 2.70 | Lorazepam for seizure prophylaxis during high-dose busulfan administration. ( Chan, KW; Choroszy, M; Koontz, S; Mullen, CA; Slopis, J; Tran, H; Worth, LL, 2002) |
| "Most seizure emergencies occur outside of the hospital, and there is a need for treatment interventions that can be administered quickly and safely by nonclinical caregivers." | 2.52 | Intranasal therapies for acute seizures. ( Kälviäinen, R, 2015) |
| "Acute seizure and status epilepticus constitute one of the major medical emergencies in children." | 2.48 | Management of acute seizure and status epilepticus in pediatric emergency. ( Sasidaran, K; Singhi, P; Singhi, S, 2012) |
| "The threshold for seizures is lowered by tramadol." | 2.41 | Lethal combination of tramadol and multiple drugs affecting serotonin. ( Levine, BS; Pestaner, JP; Ripple, MG; Smialek, JE, 2000) |
| "Minimal requirements: seizure-prevention outcome given as fraction of cases; AED or control assigned by random or quasi-random mechanism." | 2.41 | Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. ( Temkin, NR, 2001) |
| "Once SE is controlled, prevention of seizure recurrence should be individualized to each patient." | 2.40 | Management approaches to prolonged seizures and status epilepticus. ( Bleck, TP, 1999) |
| "Sequelae and risk for recurrence of SE are primarily related to the underlying cause." | 2.39 | Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment. ( Mitchell, WG, 1996) |
| "Finally, seizure-like nonepileptic disorders were reviewed and differential diagnostic points highlighted." | 2.36 | Seizures and seizure-like states in the child: an approach to emergency management. ( Oppenheimer, EY; Rosman, NP, 1983) |
| "Status Epilepticus is the most common non-traumatic neurologic emergency in childhood." | 1.72 | Resolution of status epilepticus after ketamine administration. ( Hakmeh, W; Howing, CE; Razi, F, 2022) |
| " Formulation and dosage of lorazepam were the same in both routes." | 1.62 | A Comparative Study on Intranasal Versus Intravenous Lorazepam in the Management of Acute Seizure in Children. ( Ghosh, T; Roy, UK; Rudra, N, 2021) |
| "The few in-ED seizures occurred before medication administration." | 1.56 | Lorazepam Versus Diazepam in the Management of Emergency Department Patients With Alcohol Withdrawal. ( Barbic, D; Chiu, I; Duley, S; Grafstein, E; Grunau, B; Innes, G; Kestler, A; Lane, DJ; Miles, I; Moe, J; Nolan, S; Scheuermeyer, FX; Slaunwhite, A; Sljivic, I; Ti, L; Yan, A, 2020) |
| "Early recognition and treatment of seizures is essential for optimal patient outcomes." | 1.51 | Active Seizures in Children Are Often Subtle and Unrecognized by Prehospital Providers. ( Abramson, TM; Kearl, YL; Loza-Gomez, A; Rose, E, 2019) |
| " The most common adverse events (AEs) were somnolence (7." | 1.51 | [Efficacy and Safety of Lorazepam Intravenously Administered in Subjects with Status Epilepticus or Repetitive Seizures]. ( Nakasato, N; Nakazuru, Y; Ohtsuka, Y; Terada, M, 2019) |
| "We utilized a middle cerebral artery occlusion model and examined seizure activity and brain injury using combined behavioral and electroencephalographic monitoring and histological assessments." | 1.42 | Modeling early-onset post-ischemic seizures in aging mice. ( Aljarallah, S; Eubanks, JH; Gao, X; Huang, Y; McDonald, R; Patel, N; Peng, J; Wang, J; Wu, C; Zhang, L, 2015) |
| "With either etiology, seizures are a poor prognostic factor." | 1.42 | Early-Onset Convulsive Seizures Induced by Brain Hypoxia-Ischemia in Aging Mice: Effects of Anticonvulsive Treatments. ( Aljarallah, S; Eubanks, JH; Gao, X; Huang, Y; McDonald, R; Patel, N; Peng, J; Wang, J; Wu, C; Zhang, L, 2015) |
| "Tardive seizures are typically associated with electroencephalographic evidence of ictal activity and motor manifestations of the tonic-clonic activity." | 1.40 | A case of atypical tardive seizure activity during an initial ECT titration series. ( Karim, Y; McCormick, LM; Thisayakorn, P; Yamada, T, 2014) |
| "Studies in major depressive disorder have demonstrated that suprathreshold, nondominant (right) hemisphere, unilateral electrode placement ECT has fewer adverse effects, especially cognitive adverse effects, than bitemporal ECT." | 1.40 | Successful use of right unilateral ECT for catatonia: a case series. ( Conway, C; Cristancho, P; Jewkes, D; Mon, T, 2014) |
| "Case 1: A 15-year-old boy with chronic renal failure on hemodialysis developed acute headache, hypertension, vomiting, and blurred vision followed by severe visual impairment and a secondarily generalized clonic seizure." | 1.39 | Status epilepticus amauroticus and posterior reversible encephalopathy syndrome in children. ( Connolly, MB; Huh, L; Muro, VL; Yip, S, 2013) |
| "Prolonged seizures [status epilepticus (SE)] constitute a neurological emergency that can permanently damage the brain." | 1.38 | Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice. ( Diaz-Hernandez, M; Engel, T; Garcia-Huerta, P; Gomez-Villafuertes, R; Henshall, DC; Mesuret, G; Miras-Portugal, MT; Sanz-Rodriguez, A; Tanaka, K, 2012) |
| "Fourteen days after the seizure, the patient returned for follow-up magnetic resonance imaging of the brain and head with gadolinium contrast." | 1.38 | Seizure activity during cetuximab infusion in a patient with metastatic colorectal cancer. ( Bell, WA; McClellan, NH, 2012) |
| "We report a case of a patient with status migrainosus unresponsive to analgesic therapy in whom electroencephalographic recording revealed an epileptic origin." | 1.37 | Ictal epileptic headache mimicking status migrainosus: EEG and DWI-MRI findings. ( Belcastro, V; Calabresi, P; Pierguidi, L; Striano, P; Tambasco, N, 2011) |
| "Subacute encephalopathy with seizures in chronic alcoholism (SESA) was first described in 1981 by Niedermeyer who reported alcoholic patients presenting with confusion, seizures and focal neurological deficits and is quite distinct from patients presenting with typical alcohol withdrawal seizures." | 1.37 | Subacute encephalopathy and seizures in alcoholics (SESA) presenting with non-convulsive status epilepticus. ( LaRoche, SM; Shivdat-Nanhoe, R, 2011) |
| " A reduction in the dosage of benzodiazepines in the setting of epileptic patients with predominant autonomic symptoms may need to be considered." | 1.37 | Benzodiazepines in the acute management of seizures with autonomic manifestations: anticipate complications! ( Fluss, J; Gervaix, A; Korff, CM; Lacroix, L, 2011) |
| "In a patient with SIRPIDs, aphasia and confusion, i." | 1.37 | Confusion and SIRPIDs regress with parenteral lorazepam. ( Duckworth, J; Kaplan, PW, 2011) |
| "Oral lorazepam was tolerated by the patients, but all patients needed dose reduction due to some adverse effects." | 1.36 | Oral lorazepam prevents seizure during high-dose busulfan in children undergoing hematopoietic stem cell transplantation: a prospective study. ( Amini, M; Ghavamzadeh, A; Hadjibabaie, M; Hamedani, R; Hamidieh, AA; Sadrai, S, 2010) |
| "A 41-year-old Caucasian female with MELAS syndrome, presenting with short stature, microcytic anaemia, increased blood-sedimentation rate, myopathy, hyper-gammaglobulinaemia, an iron-metabolism defect, migraine-like headaches, and stroke-like episodes, developed complex partial and generalised seizures at age 32 years." | 1.36 | Regression of stroke-like lesions in MELAS-syndrome after seizure control. ( Barton, P; Finsterer, J, 2010) |
| "Both lorazepam and MK-801 treatment conditions resulted in enhanced BSE activity during the entire fourth (untreated) withdrawal episode." | 1.33 | Lorazepam and MK-801 effects on behavioral and electrographic indices of alcohol withdrawal sensitization. ( Becker, HC; Veatch, LM, 2005) |
| "We report a case of hyponatremic seizures in a 7-year old boy with spina bifida following cystoscopy and suprapubic catheter placement." | 1.33 | Hyponatremic seizures after suprapubic catheter placement in 7-year-old child. ( Camporesi, EM; Puskas, F; Sweeney, DM; Szolnoki, JM; Upadhyay, J, 2006) |
| " To assess pharmacodynamic and neurochemical effects of zolpidem, open-field behavior, pentylenetetrazole-induced seizure threshold and benzodiazepine receptor binding in vitro were evaluated in the same animal following a single dose of zolpidem." | 1.33 | Acute zolpidem administration produces pharmacodynamic and receptor occupancy changes at similar doses. ( Fahey, JM; Grassi, JM; Greenblatt, DJ; Reddi, JM, 2006) |
| " Determining benzodiazepines that do not produce pharmacodynamic sensitivity, such as lorazepam, may allow more careful prescribing and dosing of these drugs, and perhaps even the development of specific agents which could avoid this sensitivity." | 1.33 | The effect of chronic lorazepam administration in aging mice. ( Fahey, JM; Grassi, JM; Greenblatt, DJ; Pratt, JS; Pritchard, GA; Reddi, JM; Shader, RI, 2006) |
| "The seizure was successfully treated with benzodiazepines." | 1.32 | Seizure secondary to citalopram overdose. ( Cuenca, PJ; Hoefle, JD; Holt, KR, 2004) |
| "We refined and developed models of seizure-induced neuronal death in the C57BL/6 and BALB/c strains by focally evoking seizures using intra-amygdala kainic acid." | 1.32 | Development of a model of seizure-induced hippocampal injury with features of programmed cell death in the BALB/c mouse. ( Araki, T; Henshall, DC; Lan, JQ; Schindler, CK; Shinoda, S; Simon, RP; Taki, W, 2004) |
| "Both pseudoseizures and hysterical stridor are associated commonly with sexual abuse, eating disorders, depression, substance abuse, anxiety disorders, and personality disorders." | 1.32 | Pseudoseizures and hysterical stridor. ( Kaufman, KR; Mohebati, A; Sotolongo, A, 2004) |
| "The incidence of respiratory depression following treatment of prolonged seizures with benzodiazepines is variable in the literature." | 1.31 | Respiratory depression in the acute management of seizures. ( Dooley, JM; Harrison, R; Stewart, WA, 2002) |
| " Usually, the slope of the dose-response lines for RWJ-51204 was more shallow than the full agonist anxiolytics but steeper than partial agonists in efficacy tests but typically shallow in tests for central nervous system side effects." | 1.31 | 5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide (RWJ-51204), a new nonbenzodiazepine anxiolytic. ( Carter, AR; Cheo-Isaacs, CT; Crooke, JJ; DeLuca, S; DeVine, A; Dubinsky, B; Hochman, C; Jordan, AD; Reitz, AB; Rosenthal, DI; Shank, RP; Vaidya, AH, 2002) |
| "Diphenhydramine was administered orally in the dose schedules of once daily (10, 20 and 40 mg/kg) and twice daily (5, 10 and 20 mg/kg) in separate groups during the withdrawal period." | 1.30 | Evaluation of inhibitory effect of diphenhydramine on benzodiazepine dependence in rats. ( Gupta, MB; Nath, C; Patnaik, GK; Saxena, RC, 1997) |
| "Seizures are a frequent problem confronting EMS personnel." | 1.30 | Prehospital management of the seizure patient. ( Nicholl, JS, 1999) |
| " Dose-response curves for stimulation of phosphoinositide (PI) hydrolysis by the selective metabotropic glutamate receptor (mGluR) agonist, (1S,3R)-1-aminocyclopentane dicarboxylic acid [(1S,3R)-ACPD] were performed with cortical slices from mice treated with lorazepam or vehicle for 7 days and subject to 0, 1, 2, 3, 4 and 7 days of withdrawal." | 1.29 | The effect of lorazepam tolerance and withdrawal on metabotropic glutamate receptor function. ( Mortensen, M; Suzdak, PD; Thomsen, C, 1995) |
| "After baseline recordings, seizures were induced with a pentylenetetrazol (PTZ) bolus and a 20 min infusion (5-6 mg/kg/min)." | 1.29 | Respiratory drive during status epilepticus and its treatment: comparison of diazepam and lorazepam. ( Fordyce, WE; Terndrup, TE, 1995) |
| "Pentylenetetrazole-induced seizure thresholds were similar in mice treated for 14 days with lorazepam or alprazolam, 2 mg/kg/day." | 1.29 | Chronic benzodiazepine administration. XII. Anticonvulsant cross-tolerance but distinct neurochemical effects of alprazolam and lorazepam. ( Byrnes, JJ; Greenblatt, DJ; Miller, LG; Shader, RI, 1993) |
| "Lorazepam was used to establish sedation and prevent asynchronous breathing while the infant was on the ventilator." | 1.29 | Lorazepam toxicity in a premature infant. ( Reiter, PD; Stiles, AD, 1993) |
| "Audiogenic seizures were completely blocked by 20 mg/kg dose of verapamil and nimodipine while nifedipine was partially effective." | 1.29 | Effect of calcium channel blockers on withdrawal syndrome of lorazepam in rats. ( Gupta, MB; Nath, C; Patnaik, GK; Saxena, RC, 1996) |
| "Three patients had exceptionally high seizure threshold, as determined by an empirical titration procedure." | 1.29 | Exceptionally high seizure threshold: ECT device limitations. ( Devanand, DP; Lisanby, SH; Mullen, L; Nobler, MS; Prudic, J; Sackeim, HA, 1996) |
| " Chronic administration of lorazepam reduces the coupling between the benzodiazepine agonist site and the chloride channel and concomitantly increases coupling between the channel and the inverse agonist site, while withdrawal resets the receptor coupling back to control response levels." | 1.28 | Effects of lorazepam tolerance and withdrawal on GABAA receptor operated chloride channels in mice selected for differences in ethanol withdrawal severity. ( Allan, AM; Baier, LD; Zhang, X, 1992) |
| "Seizures are a less frequent, but important complication." | 1.28 | Seizures following carotid endarterectomy. ( Kieburtz, K; Moxley, RT; Ricotta, JJ, 1990) |
| "3." | 1.28 | Lorazepam discontinuation promotes 'inverse agonist' effects of benzodiazepines. ( Greenblatt, DJ; Lopez, F; Miller, LG; Schatzki, A; Shader, RI, 1989) |
| "Infants with refractory seizures received additional phenobarbital to a maximum serum concentration of 100 micrograms/mL." | 1.28 | Rapid sequential phenobarbital treatment of neonatal seizures. ( Duchowny, MS; Gal, P; Gilman, JT; Ransom, JL; Weaver, RL, 1989) |
| "Dogs, surgically implanted with a gastric fistula, were chronically dosed with diazepam or lorazepam." | 1.27 | Physical dependence on diazepam and lorazepam in the dog. ( Cherian, S; Martin, WR; McNicholas, LF, 1983) |
| "Ro 15-1788 completely blocked type B myoclonus without decreasing the level of vigilance in the two types of baboons, and reversed the antiepileptic action of the BZs in the photosensitive ones, permitting the reappearance of myoclonus following EEG paroxysmal discharges (type A)." | 1.27 | Differential effects of the benzodiazepine antagonist Ro 15-1788 on two types of myoclonus in baboon Papio papio. ( Bryere, P; Kaijima, M; Naquet, R; Valin, A, 1983) |
| "DMCM seizures were antagonized by benzodiazepine (BZ) receptor antagonists, such as Ro 15-1788, CGS 8216 and several beta-carboline-3-carboxylates, which all fail to inhibit pentylenetetrazol seizures." | 1.27 | DMCM: a potent convulsive benzodiazepine receptor ligand. ( Petersen, EN, 1983) |
| "Lorazepam pretreated mice showed a significantly lower sensitivity to the anticonvulsant effects of the benzodiazepine (BZ) receptor ligands lorazepam, ZK 93423, ZK 91296, Ro 15-1788 and ZK 93426 administered acutely by the IP route when challenged with DMCM 24 hr after the last dose of lorazepam." | 1.27 | Lorazepam and FG 7142 induce tolerance to the DMCM antagonistic effect of benzodiazepine receptor ligands. ( Jensen, LH; Petersen, EN, 1987) |
| " In neither case were the pharmacological changes induced by chronic administration reflected by changes in the biochemical measures of the coupling between benzodiazepine binding sites and gamma-aminobutyric acid (GABA) receptors." | 1.27 | Co-existence of kindling induced by the beta-carboline, FG 7142, and tolerance to diazepam following chronic treatment in mice. ( Schneider, HH; Stephens, DN, 1988) |
| "Etidocaine and bupivacaine convulsions were more difficult to suppress than those induced by lidocaine." | 1.26 | Benzodiazepines protect mice from local anesthetic convulsions and deaths. ( Bonin, JD; de Jong, RH, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (16.55) | 18.7374 |
| 1990's | 30 (21.58) | 18.2507 |
| 2000's | 31 (22.30) | 29.6817 |
| 2010's | 40 (28.78) | 24.3611 |
| 2020's | 15 (10.79) | 2.80 |
| Authors | Studies |
|---|---|
| De Avila, C | 1 |
| Rauseo Lopez, LF | 1 |
| Mandelia, Y | 1 |
| Howing, CE | 1 |
| Razi, F | 1 |
| Hakmeh, W | 1 |
| Cruickshank, M | 1 |
| Imamura, M | 1 |
| Counsell, C | 1 |
| Aucott, L | 1 |
| Manson, P | 1 |
| Booth, C | 1 |
| Scotland, G | 1 |
| Brazzelli, M | 1 |
| Hasan, SU | 1 |
| Pervez, A | 1 |
| Bhatty, S | 1 |
| Shamim, S | 1 |
| Naeem, A | 1 |
| Naseeb, MW | 1 |
| Rudra, N | 1 |
| Ghosh, T | 1 |
| Roy, UK | 1 |
| Kienitz, R | 1 |
| Kay, L | 1 |
| Beuchat, I | 1 |
| Gelhard, S | 1 |
| von Brauchitsch, S | 1 |
| Mann, C | 1 |
| Lucaciu, A | 1 |
| Schäfer, JH | 1 |
| Siebenbrodt, K | 1 |
| Zöllner, JP | 1 |
| Schubert-Bast, S | 1 |
| Rosenow, F | 1 |
| Strzelczyk, A | 1 |
| Willems, LM | 1 |
| Kotloski, RJ | 1 |
| Gidal, BE | 1 |
| Garcia-Durillo, M | 1 |
| Frenguelli, BG | 1 |
| Rose, E | 1 |
| Abramson, TM | 1 |
| Kearl, YL | 1 |
| Loza-Gomez, A | 1 |
| Szaflarski, JP | 2 |
| Sadek, A | 2 |
| Greve, B | 2 |
| Williams, P | 2 |
| Varner, JA | 2 |
| Moseley, BD | 2 |
| Scheuermeyer, FX | 1 |
| Miles, I | 1 |
| Lane, DJ | 1 |
| Grunau, B | 1 |
| Grafstein, E | 1 |
| Sljivic, I | 1 |
| Duley, S | 1 |
| Yan, A | 1 |
| Chiu, I | 1 |
| Kestler, A | 1 |
| Barbic, D | 1 |
| Moe, J | 1 |
| Slaunwhite, A | 1 |
| Nolan, S | 1 |
| Ti, L | 1 |
| Innes, G | 1 |
| Young, G | 1 |
| Tolla, AS | 1 |
| Grinenko, O | 1 |
| Karanec, K | 1 |
| Panda, PK | 1 |
| Saini, K | 1 |
| Sharawat, IK | 1 |
| Kamdar, HA | 1 |
| Hamed, M | 1 |
| Smetana, KS | 1 |
| Shanmugam, K | 1 |
| Peters, E | 1 |
| Yasin, R | 1 |
| Thakur, G | 1 |
| Gopal, M | 1 |
| Sawalha, K | 1 |
| Greene-Chandos, D | 1 |
| Hussein, O | 1 |
| Mao, G | 1 |
| Gigliotti, MJ | 1 |
| Esplin, N | 1 |
| Sexton, K | 1 |
| Misra, UK | 1 |
| Dubey, D | 1 |
| Kalita, J | 1 |
| Thompson, J | 1 |
| Powell, JD | 1 |
| Ovakim, DH | 1 |
| Lewis, D | 1 |
| Blow, A | 1 |
| Tye, J | 1 |
| Hew-Butler, T | 1 |
| Verbraeken, R | 1 |
| Luykx, JJ | 1 |
| Leroy, A | 1 |
| Corfiotti, C | 1 |
| Nguyen The Tich, S | 1 |
| Ferrafiat, V | 1 |
| Amad, A | 1 |
| Jardri, R | 1 |
| Medjkane, F | 1 |
| Ohtsuka, Y | 1 |
| Nakasato, N | 1 |
| Nakazuru, Y | 1 |
| Terada, M | 1 |
| Owusu, KA | 1 |
| Dhakar, MB | 1 |
| Bautista, C | 1 |
| McKimmy, D | 1 |
| Cotugno, S | 1 |
| Sukumar, N | 1 |
| Deng, Y | 1 |
| Farooque, P | 1 |
| Hirsch, LJ | 1 |
| Maciel, CB | 1 |
| Burns, JM | 1 |
| Marino, A | 1 |
| Manno, M | 1 |
| Rhyee, S | 1 |
| Boyer, EW | 1 |
| Thisayakorn, P | 1 |
| Karim, Y | 1 |
| Yamada, T | 1 |
| McCormick, LM | 1 |
| Cristancho, P | 1 |
| Jewkes, D | 1 |
| Mon, T | 1 |
| Conway, C | 1 |
| Malu, CK | 1 |
| Kahamba, DM | 1 |
| Walker, TD | 2 |
| Mukampunga, C | 1 |
| Musalu, EM | 1 |
| Kokolomani, J | 1 |
| Mayamba, RM | 1 |
| Wilmshurst, JM | 1 |
| Dubru, JM | 1 |
| Misson, JP | 2 |
| Muro, VL | 1 |
| Yip, S | 1 |
| Huh, L | 1 |
| Connolly, MB | 1 |
| Allan, A | 1 |
| Cullen, J | 1 |
| Ng, YT | 1 |
| Kaputu-Kalala-Malu, C | 1 |
| Wu, C | 2 |
| Wang, J | 2 |
| Peng, J | 2 |
| Patel, N | 2 |
| Huang, Y | 2 |
| Gao, X | 2 |
| Aljarallah, S | 2 |
| Eubanks, JH | 2 |
| McDonald, R | 2 |
| Zhang, L | 3 |
| Kälviäinen, R | 1 |
| Wu, W | 1 |
| Xue, R | 1 |
| Gersner, R | 1 |
| Dhamne, SC | 1 |
| Zangen, A | 1 |
| Pascual-Leone, A | 1 |
| Rotenberg, A | 1 |
| Brigo, F | 1 |
| Bragazzi, NL | 1 |
| Bacigaluppi, S | 1 |
| Nardone, R | 1 |
| Trinka, E | 1 |
| Kalimullah, EA | 1 |
| Bryant, SM | 1 |
| Kriel, RL | 1 |
| Cloyd, JC | 1 |
| Freedman, BD | 1 |
| Hughan, K | 1 |
| Garibaldi, L | 1 |
| Venkat, A | 1 |
| Marynowski, MT | 1 |
| Belcastro, V | 1 |
| Striano, P | 1 |
| Pierguidi, L | 1 |
| Calabresi, P | 1 |
| Tambasco, N | 1 |
| Hamidieh, AA | 1 |
| Hamedani, R | 1 |
| Hadjibabaie, M | 1 |
| Amini, M | 1 |
| Sadrai, S | 1 |
| Ghavamzadeh, A | 1 |
| Bin Salih, S | 1 |
| Al Qahtani, M | 1 |
| Al Anazi, T | 1 |
| Al Hussein, M | 1 |
| Al Hayyan, H | 1 |
| Al Modaimegh, H | 1 |
| Finsterer, J | 1 |
| Barton, P | 1 |
| Arya, R | 1 |
| Gulati, S | 1 |
| Kabra, M | 1 |
| Sahu, JK | 1 |
| Kalra, V | 1 |
| Lagae, L | 1 |
| Al-Khamees, WA | 1 |
| Schwartz, MD | 1 |
| Alrashdi, S | 1 |
| Algren, AD | 1 |
| Morgan, BW | 1 |
| LaRoche, SM | 1 |
| Shivdat-Nanhoe, R | 1 |
| Gathwala, G | 1 |
| Goel, M | 1 |
| Singh, J | 1 |
| Mittal, K | 1 |
| Lacroix, L | 1 |
| Fluss, J | 1 |
| Gervaix, A | 1 |
| Korff, CM | 1 |
| Kaplan, PW | 1 |
| Duckworth, J | 1 |
| Sasidaran, K | 1 |
| Singhi, S | 1 |
| Singhi, P | 1 |
| Engel, T | 1 |
| Gomez-Villafuertes, R | 1 |
| Tanaka, K | 1 |
| Mesuret, G | 1 |
| Sanz-Rodriguez, A | 1 |
| Garcia-Huerta, P | 1 |
| Miras-Portugal, MT | 1 |
| Henshall, DC | 2 |
| Diaz-Hernandez, M | 1 |
| Aneja, S | 1 |
| McClellan, NH | 1 |
| Bell, WA | 1 |
| Sahana, KS | 1 |
| Rajiv, D | 1 |
| Bravo, TP | 1 |
| Hoffman-Snyder, CR | 1 |
| Wellik, KE | 1 |
| Martin, KA | 1 |
| Hoerth, MT | 1 |
| Demaerschalk, BM | 1 |
| Wingerchuk, DM | 1 |
| Stewart, WA | 1 |
| Harrison, R | 1 |
| Dooley, JM | 1 |
| Dubinsky, B | 1 |
| Vaidya, AH | 1 |
| Rosenthal, DI | 1 |
| Hochman, C | 1 |
| Crooke, JJ | 1 |
| DeLuca, S | 1 |
| DeVine, A | 1 |
| Cheo-Isaacs, CT | 1 |
| Carter, AR | 1 |
| Jordan, AD | 1 |
| Reitz, AB | 1 |
| Shank, RP | 1 |
| Cuenca, PJ | 1 |
| Holt, KR | 1 |
| Hoefle, JD | 1 |
| Shinoda, S | 1 |
| Araki, T | 1 |
| Lan, JQ | 1 |
| Schindler, CK | 1 |
| Simon, RP | 1 |
| Taki, W | 1 |
| Kaufman, KR | 1 |
| Mohebati, A | 1 |
| Sotolongo, A | 1 |
| Sanna, E | 1 |
| Busonero, F | 1 |
| Talani, G | 1 |
| Mostallino, MC | 1 |
| Mura, ML | 1 |
| Pisu, MG | 1 |
| Maciocco, E | 1 |
| Serra, M | 1 |
| Biggio, G | 1 |
| Veatch, LM | 1 |
| Becker, HC | 1 |
| Szolnoki, JM | 1 |
| Puskas, F | 1 |
| Sweeney, DM | 1 |
| Camporesi, EM | 1 |
| Upadhyay, J | 1 |
| Fahey, JM | 3 |
| Grassi, JM | 2 |
| Reddi, JM | 2 |
| Greenblatt, DJ | 7 |
| Goyal, M | 1 |
| Wiznitzer, M | 1 |
| Ahmad, S | 1 |
| Ellis, JC | 1 |
| Kamwendo, H | 1 |
| Molyneux, E | 2 |
| Nagler, J | 1 |
| Poppers, D | 1 |
| Turetz, M | 1 |
| Pritchard, GA | 3 |
| Pratt, JS | 2 |
| Shader, RI | 5 |
| Cearnal, L | 1 |
| Muchohi, SN | 1 |
| Obiero, K | 1 |
| Newton, CR | 1 |
| Ogutu, BR | 1 |
| Edwards, G | 1 |
| Kokwaro, GO | 1 |
| Bartha, AI | 1 |
| Shen, J | 1 |
| Katz, KH | 1 |
| Mischel, RE | 1 |
| Yap, KR | 1 |
| Ivacko, JA | 1 |
| Andrews, EM | 1 |
| Ferriero, DM | 1 |
| Ment, LR | 1 |
| Silverstein, FS | 1 |
| DiFazio, MP | 1 |
| Braun, L | 1 |
| Freedman, S | 1 |
| Hickey, P | 1 |
| Caselli, D | 1 |
| Ziino, O | 1 |
| Bartoli, A | 1 |
| Santangelo, G | 1 |
| Vanadia, F | 1 |
| Aricò, M | 1 |
| Howe, JG | 1 |
| Kostowski, W | 1 |
| Płaźnik, A | 1 |
| Puciłowski, O | 1 |
| Trzaskowska, E | 1 |
| Lipińska, T | 1 |
| McNicholas, LF | 1 |
| Martin, WR | 1 |
| Cherian, S | 1 |
| Valin, A | 2 |
| Kaijima, M | 1 |
| Bryere, P | 1 |
| Naquet, R | 2 |
| Cepeda, C | 1 |
| Rey, E | 1 |
| Petersen, EN | 3 |
| Jensen, LH | 2 |
| Oppenheimer, EY | 1 |
| Rosman, NP | 1 |
| Kahan, BB | 1 |
| Haskett, RF | 1 |
| de Jong, RH | 1 |
| Bonin, JD | 1 |
| Mortensen, M | 1 |
| Suzdak, PD | 1 |
| Thomsen, C | 1 |
| Appleton, R | 1 |
| Sweeney, A | 1 |
| Choonara, I | 1 |
| Robson, J | 1 |
| Koff, JM | 2 |
| Miller, LG | 5 |
| Terndrup, TE | 1 |
| Fordyce, WE | 1 |
| Lee, DS | 1 |
| Wong, HA | 1 |
| Knoppert, DC | 1 |
| Byrnes, JJ | 2 |
| Reiter, PD | 1 |
| Stiles, AD | 1 |
| Perkins, K | 1 |
| Mitchell, WG | 2 |
| Gupta, MB | 3 |
| Nath, C | 3 |
| Patnaik, GK | 2 |
| Saxena, RC | 3 |
| Martínez-Cano, H | 1 |
| Vela-Bueno, A | 1 |
| de Iceta, M | 1 |
| Pomalima, R | 1 |
| Martínez-Gras, I | 1 |
| Lisanby, SH | 1 |
| Devanand, DP | 1 |
| Nobler, MS | 1 |
| Prudic, J | 1 |
| Mullen, L | 1 |
| Sackeim, HA | 1 |
| Valentine, JL | 1 |
| Schexnayder, S | 1 |
| Jones, JG | 1 |
| Sturner, WQ | 1 |
| Naassila, M | 1 |
| Legrand, E | 1 |
| d'Alche-Birée, F | 1 |
| Daoust, M | 1 |
| D'Onofrio, G | 2 |
| Rathlev, NK | 2 |
| Ulrich, AS | 1 |
| Fish, SS | 2 |
| Freedland, ES | 1 |
| Lane, HY | 1 |
| Su, KP | 1 |
| Chang, WH | 1 |
| Bleck, TP | 1 |
| Sosis, MB | 1 |
| Matz, R | 1 |
| Seidl, JJ | 1 |
| Layde, P | 1 |
| Nicholl, JS | 1 |
| Harris, M | 2 |
| Gausman, D | 1 |
| Little, JS | 1 |
| Ulrich, A | 1 |
| Ripple, MG | 1 |
| Pestaner, JP | 1 |
| Levine, BS | 1 |
| Smialek, JE | 1 |
| Shannon, M | 1 |
| Quang, LS | 1 |
| Temkin, NR | 1 |
| Noerr, B | 1 |
| Chan, KW | 1 |
| Mullen, CA | 1 |
| Worth, LL | 1 |
| Choroszy, M | 1 |
| Koontz, S | 1 |
| Tran, H | 1 |
| Slopis, J | 1 |
| Markovich, VV | 1 |
| Ostrovskaia, RU | 1 |
| Gluckman, MI | 1 |
| Stein, L | 1 |
| Morita, Y | 1 |
| Shinkuma, D | 1 |
| Shibagaki, N | 1 |
| Allan, AM | 1 |
| Baier, LD | 1 |
| Zhang, X | 1 |
| McDermott, CA | 1 |
| Kowalczyk, AL | 1 |
| Schnitzler, ER | 1 |
| Mangurten, HH | 2 |
| Rodvold, KA | 1 |
| Metrick, S | 1 |
| King, L | 1 |
| Piot, O | 1 |
| Betschart, J | 1 |
| Stutzmann, JM | 1 |
| Blanchard, JC | 1 |
| File, SE | 2 |
| Wilks, LJ | 2 |
| Kieburtz, K | 1 |
| Ricotta, JJ | 1 |
| Moxley, RT | 1 |
| Mabbutt, PS | 1 |
| Schatzki, A | 1 |
| Lopez, F | 1 |
| Gilman, JT | 1 |
| Gal, P | 1 |
| Duchowny, MS | 1 |
| Weaver, RL | 1 |
| Ransom, JL | 1 |
| Uthman, BM | 1 |
| Wilder, BJ | 1 |
| Schneider, HH | 1 |
| Stephens, DN | 1 |
| Nutt, DJ | 1 |
| Costello, MJ | 1 |
| Celesia, GG | 1 |
| Grigg, MM | 1 |
| Ross, E | 1 |
| Deshmukh, A | 1 |
| Wittert, W | 1 |
| Schnitzler, E | 1 |
| Crawford, TO | 1 |
| Snodgrass, SR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Sub-dissociative Intranasal Ketamine Plus Standard Pain Therapy Versus Standard Pain Therapy in the Treatment of Pediatric Sickle Cell Disease Vasoocclusive Crises in Resource-limited Settings: a Multi-centered, Randomized, Controlled Trial[NCT02573714] | 160 participants (Anticipated) | Interventional | 2015-12-31 | Recruiting | |||
| Intra-Nasal vs. Intra-Venous Lorazepam for Control of Acute Seizures in Children: Prospective Open Labeled Randomized Equivalence Trial[NCT00735527] | Phase 3 | 140 participants (Anticipated) | Interventional | 2008-05-31 | Completed | ||
| A Randomised Trial to Compare the Efficacy and Safety of Intranasal Lorazepam and Intramuscular Paraldehyde in the Treatment of Convulsions in Children[NCT00116064] | Phase 3 | 156 participants | Interventional | 2004-07-31 | Completed | ||
| Effect of Bupropion on Seizure Threshold in Depressed Patients[NCT03126682] | Phase 4 | 10 participants (Actual) | Interventional | 2017-08-25 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Scoring of depressive symptoms on the Montgomery Asberg Depression Rating Scale, maximum 60 , minimum 0. Higher scores mean worse outcome. First measurement on day 1 of electroconvulsive treatment (ECT) and second measurement on day 2 of electroconvulsive therapy (ECT), separated by 1 day interval. This outcome measure was not measured at baseline. (NCT03126682)
Timeframe: Scored on day 1 and day 2 after ECT session
| Intervention | Scored on a scale (Mean) |
|---|---|
| Wellbutrin During ECT 1 | 2.60 |
| Wellbutrin During ECT 2 | 3.60 |
Duration of seizures with ECT. First measurement on day 1 of electroconvulsive treatment (ECT) and second measurement on day 2 of electroconvulsive therapy (ECT), separated by 1 day interval. This outcome measure was not measured at baseline. (NCT03126682)
Timeframe: Measured at day 1 and day 2
| Intervention | seconds (Mean) |
|---|---|
| Wellbutrin During ECT 1 | 26.2 |
| Wellbutrin During ECT 2 | 29.6 |
Charge in Millicoulombs at which subject gets a seizure with ECT. First measurement on day 1 of electroconvulsive treatment (ECT) and second measurement on day 2 of electroconvulsive therapy (ECT), separated by 1 day interval. This outcome measure was not measured at baseline. (NCT03126682)
Timeframe: Measured at day 1 and day 2
| Intervention | millicoulombs (Mean) |
|---|---|
| Wellbutrin During ECT 1 | 23.04 |
| Wellbutrin During ECT 2 | 19.68 |
17 reviews available for lorazepam and Absence Seizure
| Article | Year |
|---|---|
Management of the first stage of convulsive status epilepticus in adults: a systematic review of current randomised evidence.
Topics: Adult; Anticonvulsants; Diazepam; Humans; Lorazepam; Midazolam; Seizures; Status Epilepticus | 2022 |
Termination of seizures in the paediatric age group, best benzodiazepine and route of administration: A network meta-analysis.
Topics: Anticonvulsants; Benzodiazepines; Child; Diazepam; Humans; Lorazepam; Midazolam; Network Meta-Analys | 2022 |
Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability.
Topics: Anticonvulsants; Benzodiazepines; Clonazepam; Diazepam; gamma-Aminobutyric Acid; Humans; Lorazepam; | 2022 |
Rescue Treatments for Seizure Clusters.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Diazepam; Humans; Lorazepam; Midazolam; Nasal S | 2022 |
Persistent catatonia following epileptic seizures: a case report and systematic literature search.
Topics: Adult; Anticonvulsants; Catatonia; Humans; Lorazepam; Male; Seizures | 2018 |
Best BETs from the Manchester Royal Infirmary. BET 1: intranasal lorazepam is an acceptable alternative to intravenous lorazepam in the control of acute seizures in children.
Topics: Acute Disease; Administration, Intranasal; Anticonvulsants; Child, Preschool; Evidence-Based Emergen | 2013 |
Intranasal therapies for acute seizures.
Topics: Acute Disease; Administration, Intranasal; Anticonvulsants; Diazepam; Humans; Lorazepam; Midazolam; | 2015 |
Lorazepam or diazepam for convulsive status epilepticus: A meta-analysis.
Topics: Anticonvulsants; Diazepam; Humans; Lorazepam; Seizures; Status Epilepticus; Treatment Outcome | 2016 |
Is intravenous lorazepam really more effective and safe than intravenous diazepam as first-line treatment for convulsive status epilepticus? A systematic review with meta-analysis of randomized controlled trials.
Topics: Administration, Intravenous; Anticonvulsants; Diazepam; Humans; Lorazepam; Randomized Controlled Tri | 2016 |
Clinical practice: the treatment of acute convulsive seizures in children.
Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Child; Diazepam; GABA Modulators; Humans; Lorazepam | 2011 |
Management of acute seizure and status epilepticus in pediatric emergency.
Topics: Anesthesia, Intravenous; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Combined Modalit | 2012 |
Seizures and seizure-like states in the child: an approach to emergency management.
Topics: Anesthesia, General; Child; Child, Preschool; Diagnosis, Differential; Diazepam; Emergencies; Humans | 1983 |
Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Benzodiazepines; Central Nervous System Disea | 1996 |
Management approaches to prolonged seizures and status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Diazepam; Drug Administration Schedule; Drug Therapy, Combination; | 1999 |
Lethal combination of tramadol and multiple drugs affecting serotonin.
Topics: Adult; Alcoholism; Analgesics, Opioid; Cyclohexanols; Dibenzothiazepines; Drug Interactions; Fatal O | 2000 |
Gamma-hydroxybutyrate, gamma-butyrolactone, and 1,4-butanediol: a case report and review of the literature.
Topics: 4-Butyrolactone; Adjuvants, Anesthesia; Adolescent; Butylene Glycols; Emergency Medical Services; Fe | 2000 |
Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials.
Topics: Anticonvulsants; Brain Diseases; Brain Injuries; Carbamazepine; Controlled Clinical Trials as Topic; | 2001 |
11 trials available for lorazepam and Absence Seizure
| Article | Year |
|---|---|
Randomized open-label trial of intravenous brivaracetam versus lorazepam for acute treatment of increased seizure activity.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Anticonvulsants; Dizziness; Double-Blind Metho | 2020 |
Comparison of lacosamide versus sodium valproate in status epilepticus: A pilot study.
Topics: Acetamides; Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants | 2017 |
Efficacy of sublingual lorazepam versus intrarectal diazepam for prolonged convulsions in Sub-Saharan Africa.
Topics: Administration, Rectal; Administration, Sublingual; Africa South of the Sahara; Anticonvulsants; Chi | 2014 |
Intranasal versus intravenous lorazepam for control of acute seizures in children: a randomized open-label study.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Anticonvulsants; Child; Female; Humans; Injec | 2011 |
Intranasal versus intravenous lorazepam for control of acute seizures in children: a randomized open-label study.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Anticonvulsants; Child; Female; Humans; Injec | 2011 |
Intranasal versus intravenous lorazepam for control of acute seizures in children: a randomized open-label study.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Anticonvulsants; Child; Female; Humans; Injec | 2011 |
Intranasal versus intravenous lorazepam for control of acute seizures in children: a randomized open-label study.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Anticonvulsants; Child; Female; Humans; Injec | 2011 |
Intravenous diazepam, midazolam and lorazepam in acute seizure control.
Topics: Acute Disease; Adolescent; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Injections, In | 2012 |
The effect of selective serotonin reuptake inhibitors on the frequency of psychogenic nonepileptic seizures: a critically appraised topic.
Topics: Anti-Anxiety Agents; Anticonvulsants; Conversion Disorder; Electroencephalography; Female; Humans; L | 2013 |
Efficacy and safety of intranasal lorazepam versus intramuscular paraldehyde for protracted convulsions in children: an open randomised trial.
Topics: Administration, Intranasal; Anticonvulsants; Child, Preschool; Emergency Service, Hospital; Female; | 2006 |
Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and convulsions.
Topics: Africa; Anticonvulsants; Child; Child, Preschool; Female; Humans; Infant; Injections, Intramuscular; | 2008 |
Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus.
Topics: Administration, Rectal; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Injections, Intravenou | 1995 |
Lorazepam for the prevention of recurrent seizures related to alcohol.
Topics: Adult; Alcoholism; Anticonvulsants; Double-Blind Method; Ethanol; Female; Humans; Injections, Intrav | 1999 |
Lorazepam for seizure prophylaxis during high-dose busulfan administration.
Topics: Adolescent; Adult; Anticonvulsants; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemo | 2002 |
111 other studies available for lorazepam and Absence Seizure
| Article | Year |
|---|---|
Acute COVID-19 Infection Associated With Necrotizing Disseminated Acute Leukoencephalopathy and Brain Microhemorrhages in a Pediatric Patient.
Topics: Adolescent; Anticonvulsants; COVID-19; COVID-19 Drug Treatment; Female; Humans; Immunoglobulins, Int | 2021 |
Resolution of status epilepticus after ketamine administration.
Topics: Aftercare; Anticonvulsants; COVID-19; Female; Humans; Infant; Ketamine; Levetiracetam; Lorazepam; Pa | 2022 |
A Comparative Study on Intranasal Versus Intravenous Lorazepam in the Management of Acute Seizure in Children.
Topics: Administration, Intranasal; Anticonvulsants; Child; Cross-Sectional Studies; Humans; Lorazepam; Seiz | 2021 |
Antagonism of P2X7 receptors enhances lorazepam action in delaying seizure onset in an in vitro model of status epilepticus.
Topics: Animals; Lorazepam; Male; Membrane Proteins; Mice; Purinergic P2X Receptor Antagonists; Receptors, P | 2023 |
Active Seizures in Children Are Often Subtle and Unrecognized by Prehospital Providers.
Topics: Administration, Intravenous; Adolescent; Anticonvulsants; Child; Child, Preschool; Early Diagnosis; | 2019 |
Lorazepam Versus Diazepam in the Management of Emergency Department Patients With Alcohol Withdrawal.
Topics: Adult; Alcoholism; Benzodiazepines; Canada; Diazepam; Emergency Service, Hospital; Female; Hospitali | 2020 |
Neuropsychiatric manifestations in adult-onset Still's disease.
Topics: Aggression; Anticonvulsants; Arthralgia; Diagnosis, Differential; Electroencephalography; Female; Fe | 2020 |
Intravenous brivaracetam and lorazepam for acute seizure control: Are they equally effective?
Topics: Humans; Lorazepam; Pyrrolidinones; Seizures | 2020 |
Lorazepam timing for acute convulsive seizure control (LoTASC).
Topics: Acute Disease; Adult; Aged; Anticonvulsants; Benzodiazepines; Diazepam; Female; Humans; Lorazepam; M | 2020 |
Response to Letter to the Editor "Intravenous brivaracetam and lorazepam for acute seizure control: Are they equally effective?"
Topics: Administration, Intravenous; Humans; Lorazepam; Pyrrolidinones; Seizures | 2020 |
The clinical impact and safety profile of high-dose intra-arterial verapamil treatment for cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
Topics: Aneurysm, Ruptured; Anticonvulsants; Brain Ischemia; Dose-Response Relationship, Drug; Female; Funct | 2021 |
Intentional overdose of the novel anti-epileptic drug eslicarbazepine presenting with recurrent seizures and ventricular dysrhythmias.
Topics: Adolescent; Anticonvulsants; Dibenzazepines; Drug Overdose; Female; Heart Arrest; Humans; Hypoxia; L | 2018 |
Considering exercise-associated hyponatraemia as a continuum.
Topics: Adult; Aftercare; Anticonvulsants; Antidiuretic Agents; Confusion; Cystic Fibrosis; Deamino Arginine | 2018 |
Catatonia Associated With a
Topics: Anticonvulsants; Catatonia; Child, Preschool; Humans; Lorazepam; Mutation; NAV1.2 Voltage-Gated Sodi | 2018 |
[Efficacy and Safety of Lorazepam Intravenously Administered in Subjects with Status Epilepticus or Repetitive Seizures].
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Humans; Injections, Intravenous; Loraze | 2019 |
Comparison of intranasal midazolam versus intravenous lorazepam for seizure termination and prevention of seizure clusters in the adult epilepsy monitoring unit.
Topics: Administration, Intranasal; Administration, Intravenous; Adult; Anticonvulsants; Epilepsy; Female; H | 2019 |
Status epilepticus in a child secondary to ingestion of skin-lightening cream.
Topics: Anticonvulsants; Ataxia; Eating; Emergencies; Humans; Hydroquinones; Infant; Intubation, Intratrache | 2013 |
A case of atypical tardive seizure activity during an initial ECT titration series.
Topics: Adult; Anticonvulsants; Brain; Depressive Disorder, Major; Electroconvulsive Therapy; Electroencepha | 2014 |
Successful use of right unilateral ECT for catatonia: a case series.
Topics: Adolescent; Adult; Aged, 80 and over; Antipsychotic Agents; Bipolar Disorder; Catatonia; Depressive | 2014 |
Status epilepticus amauroticus and posterior reversible encephalopathy syndrome in children.
Topics: Adolescent; Anticonvulsants; beta-Thalassemia; Blindness; Bone Marrow Transplantation; Child; Diffus | 2013 |
The efficacy of sublingual Lorazepam for prolonged convulsions beyond sub-saharan Africa: raising more questions than answers.
Topics: Anticonvulsants; Diazepam; Female; Humans; Lorazepam; Male; Seizures | 2014 |
Reply to comment on "Efficacy of sublingual Lorazepam for prolonged convulsions beyond sub-Saharan Africa".
Topics: Anticonvulsants; Diazepam; Female; Humans; Lorazepam; Male; Seizures | 2014 |
Modeling early-onset post-ischemic seizures in aging mice.
Topics: Aging; Analysis of Variance; Animals; Anticonvulsants; Brain; Chi-Square Distribution; Disease Model | 2015 |
Early-Onset Convulsive Seizures Induced by Brain Hypoxia-Ischemia in Aging Mice: Effects of Anticonvulsive Treatments.
Topics: Age of Onset; Aging; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Hippocampus; | 2015 |
Bursts of high-frequency repetitive transcranial magnetic stimulation (rTMS), together with lorazepam, suppress seizures in a rat kainate status epilepticus model.
Topics: Animals; Anticonvulsants; Combined Modality Therapy; Disease Models, Animal; Kainic Acid; Lorazepam; | 2016 |
Case files of the medical toxicology fellowship at the toxikon consortium in Chicago: cocaine-associated wide-complex dysrhythmias and cardiac arrest - treatment nuances and controversies.
Topics: Amiodarone; Anti-Arrhythmia Agents; Anticonvulsants; Antidotes; Arrhythmias, Cardiac; Charcoal; Coca | 2008 |
Treatment of community-onset childhood convulsive status epilepticus.
Topics: Administration, Rectal; Anticonvulsants; Child; Diazepam; Humans; Injections, Intravenous; Lorazepam | 2009 |
Hypoglycemic seizure.
Topics: Adrenoleukodystrophy; Anticonvulsants; Blood Glucose; Child, Preschool; Glucose; Humans; Hypoglycemi | 2010 |
Seizure activity demonstrated on electrocardiogram.
Topics: Aged; Anticonvulsants; Diagnosis, Differential; Electrocardiography; Humans; Lorazepam; Male; Seizur | 2009 |
Ictal epileptic headache mimicking status migrainosus: EEG and DWI-MRI findings.
Topics: Anticonvulsants; Diffusion Magnetic Resonance Imaging; Electroencephalography; Epilepsy; Female; Hea | 2011 |
Oral lorazepam prevents seizure during high-dose busulfan in children undergoing hematopoietic stem cell transplantation: a prospective study.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Busulfan; Child; Child, Preschool; Dose-Response | 2010 |
Metabolic acidosis and generalized seizures secondary to citalopram overdose: a case report.
Topics: Acidosis; Anticonvulsants; Citalopram; Depression; Drug Overdose; Female; Humans; Lorazepam; Seizure | 2010 |
Regression of stroke-like lesions in MELAS-syndrome after seizure control.
Topics: Adult; Anticonvulsants; Cerebral Cortex; Diagnosis, Differential; Electroencephalography; Female; Hu | 2010 |
Status epilepticus associated with borage oil ingestion.
Topics: Acyclovir; Adult; Anticonvulsants; Borago; Diethylcarbamazine; Drug Therapy, Combination; Female; ga | 2011 |
Subacute encephalopathy and seizures in alcoholics (SESA) presenting with non-convulsive status epilepticus.
Topics: Acetamides; Alcohol Withdrawal Seizures; Alcoholism; Anticonvulsants; Brain Diseases; Confusion; Dif | 2011 |
Benzodiazepines in the acute management of seizures with autonomic manifestations: anticipate complications!
Topics: Autonomic Nervous System Diseases; Benzodiazepines; Child; Child, Preschool; Diazepam; Female; Human | 2011 |
Confusion and SIRPIDs regress with parenteral lorazepam.
Topics: Aged; Anticoagulants; Anticonvulsants; Confusion; Consciousness Disorders; Diabetes Complications; E | 2011 |
Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Cells, Cultured; Excitatory Amino Acid Agonists; G | 2012 |
Benzodiazepines for acute management of seizures.
Topics: Diazepam; Female; Humans; Lorazepam; Male; Midazolam; Seizures | 2012 |
Seizure activity during cetuximab infusion in a patient with metastatic colorectal cancer.
Topics: Antibodies, Monoclonal, Humanized; Anticonvulsants; Antineoplastic Agents; Cetuximab; Colorectal Neo | 2012 |
Camphor poisoning.
Topics: Anticonvulsants; Camphor; Child, Preschool; Humans; Lorazepam; Male; Neurotoxins; Poisoning; Seizure | 2012 |
Respiratory depression in the acute management of seizures.
Topics: Anticonvulsants; Child; Child, Preschool; Chronic Disease; Diazepam; Drug Therapy, Combination; Huma | 2002 |
5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide (RWJ-51204), a new nonbenzodiazepine anxiolytic.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Central Nervous System Depressants; Chlordiazepoxide | 2002 |
Seizure secondary to citalopram overdose.
Topics: Adenosine; Adult; Anti-Arrhythmia Agents; Anticonvulsants; Antidepressive Agents, Second-Generation; | 2004 |
Development of a model of seizure-induced hippocampal injury with features of programmed cell death in the BALB/c mouse.
Topics: Animals; Anticonvulsants; Apoptosis; Blotting, Western; Caspase 8; Caspases; Diazepam; DNA Fragmenta | 2004 |
Pseudoseizures and hysterical stridor.
Topics: Academic Medical Centers; Adult; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents, Second | 2004 |
Low tolerance and dependence liabilities of etizolam: molecular, functional, and pharmacological correlates.
Topics: Animals; Animals, Newborn; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cul | 2005 |
Lorazepam and MK-801 effects on behavioral and electrographic indices of alcohol withdrawal sensitization.
Topics: Animals; Area Under Curve; Behavior, Animal; Central Nervous System Depressants; Dizocilpine Maleate | 2005 |
Hyponatremic seizures after suprapubic catheter placement in 7-year-old child.
Topics: Abdominal Wall; Anticonvulsants; Catheterization; Child; Cystoscopy; Diuretics; Furosemide; Glucose; | 2006 |
Acute zolpidem administration produces pharmacodynamic and receptor occupancy changes at similar doses.
Topics: Animals; Anticonvulsants; Binding, Competitive; Convulsants; Dose-Response Relationship, Drug; Fluni | 2006 |
Emergency management of seizures in children.
Topics: Administration, Intranasal; Anticonvulsants; Child; Child, Preschool; Drug Storage; Emergency Medica | 2006 |
Severe hyponatremia and seizure following a polyethylene glycol-based bowel preparation for colonoscopy.
Topics: Aged; Anticonvulsants; Cathartics; Colonoscopy; Female; Humans; Hyponatremia; Lorazepam; Polyethylen | 2006 |
The effect of chronic lorazepam administration in aging mice.
Topics: Aging; Animals; Brain; Cerebral Cortex; Convulsants; Drug Administration Schedule; Drug Interactions | 2006 |
The birth of the NETT: NIH-funded network will launch emergency neurological trials.
Topics: Anticonvulsants; Clinical Trials as Topic; Emergency Medical Services; Humans; Informed Consent; Lor | 2006 |
Neonatal seizures: multicenter variability in current treatment practices.
Topics: Anticonvulsants; Consensus; Electroencephalography; Female; Humans; Infant, Newborn; Intensive Care, | 2007 |
Rotavirus-induced seizures in childhood.
Topics: Anticonvulsants; Child, Preschool; Diarrhea; Enterovirus; Feces; Female; Follow-Up Studies; Humans; | 2007 |
Continuous intravenous infusion of lorazepam as seizure prophylaxis in children treated with high-dose busulfan.
Topics: Adolescent; Anticonvulsants; Busulfan; Child; Child, Preschool; Humans; Infant; Infusions, Intraveno | 2008 |
Lorazepam withdrawal seizures.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Female; Humans; Lorazepam; Seizures; Substance Withdrawal Syndr | 1980 |
Some behavioral effects of chlorodesmethyldiazepam and lorazepam.
Topics: Acoustic Stimulation; Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; D | 1981 |
Physical dependence on diazepam and lorazepam in the dog.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Dogs; Female; Gait; Humans; Lorazepam; Pyrazole | 1983 |
Differential effects of the benzodiazepine antagonist Ro 15-1788 on two types of myoclonus in baboon Papio papio.
Topics: 5-Hydroxytryptophan; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepinones; Flumazenil; g | 1983 |
Opposite effects of lorazepam on two kinds of myoclonus in the photosensitive Papio papio.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Cerebral Cortex; Dose-Response Relationship, Drug; E | 1981 |
DMCM: a potent convulsive benzodiazepine receptor ligand.
Topics: Animals; Carbolines; Convulsants; Diazepam; Drug Interactions; Female; Indoles; Lorazepam; Male; Mic | 1983 |
Bidirectional effects of benzodiazepine receptor ligands against picrotoxin- and pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Brain; Convulsants; Dose-Response Relationship, Drug; F | 1983 |
Lorazepam withdrawal and seizures.
Topics: Adolescent; Depressive Disorder; Female; Humans; Lorazepam; Seizures; Substance Withdrawal Syndrome | 1984 |
Benzodiazepines protect mice from local anesthetic convulsions and deaths.
Topics: Anesthetics; Animals; Benzodiazepines; Bupivacaine; Diazepam; Drug Interactions; Etidocaine; Female; | 1981 |
The effect of lorazepam tolerance and withdrawal on metabotropic glutamate receptor function.
Topics: Animals; Cerebral Cortex; Cyclic AMP; Cycloleucine; Drug Tolerance; Hydrolysis; In Vitro Techniques; | 1995 |
Prenatal lorazepam exposure: 4. Persistent alterations in pentylenetetrazole-induced seizure threshold and GABA-dependent chloride uptake after prenatal lorazepam exposure.
Topics: Animals; Brain Chemistry; Chlorides; Chlorine; Female; gamma-Aminobutyric Acid; Lorazepam; Mice; Mus | 1995 |
Respiratory drive during status epilepticus and its treatment: comparison of diazepam and lorazepam.
Topics: Animals; Diazepam; Disease Models, Animal; Epilepsy, Tonic-Clonic; Hydrogen-Ion Concentration; Loraz | 1995 |
Myoclonus associated with lorazepam therapy in very-low-birth-weight infants.
Topics: Female; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature; Injections, Intravenou | 1994 |
Chronic benzodiazepine administration. XII. Anticonvulsant cross-tolerance but distinct neurochemical effects of alprazolam and lorazepam.
Topics: Alprazolam; Animals; Anticonvulsants; Brain Chemistry; Cerebral Cortex; Down-Regulation; Drug Tolera | 1993 |
Lorazepam toxicity in a premature infant.
Topics: Administration, Inhalation; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; | 1993 |
Chronic benzodiazepine administration. XI. Concurrent administration of PK11195 attenuates lorazepam discontinuation effects.
Topics: Animals; Benzodiazepinones; Cerebral Cortex; Convulsants; Dose-Response Relationship, Drug; GABA-A R | 1993 |
Effect of calcium channel blockers on withdrawal syndrome of lorazepam in rats.
Topics: Acoustic Stimulation; Aggression; Animals; Body Temperature; Calcium Channel Blockers; Female; Loraz | 1996 |
Benzodiazepine withdrawal syndrome seizures.
Topics: Adult; Anti-Anxiety Agents; Female; Flunitrazepam; Heroin Dependence; Humans; Hypnotics and Sedative | 1995 |
Exceptionally high seizure threshold: ECT device limitations.
Topics: Aged; Aged, 80 and over; Anti-Anxiety Agents; Bipolar Disorder; Depressive Disorder; Electroconvulsi | 1996 |
Clinical and toxicological findings in two young siblings and autopsy findings in one sibling with multiple hospital admissions resulting in death. Evidence suggesting Munchausen syndrome by proxy.
Topics: Anti-Anxiety Agents; Apnea; Autopsy; Child Abuse; Emergencies; Feces; Female; Hospitals, University; | 1997 |
The NMDA receptor competitive antagonist CPP modulates benzodiazepine tolerance and discontinuation.
Topics: Animals; Cerebral Cortex; Drug Interactions; Drug Tolerance; Excitatory Amino Acid Antagonists; Hipp | 1997 |
Cyamemazine decreases ethanol intake in rats and convulsions during ethanol withdrawal syndrome in mice.
Topics: Alcohol Deterrents; Alcohol Drinking; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Central Ne | 1998 |
Lorazepam attenuates the behavioral effects of dizocilpine.
Topics: Animals; Dizocilpine Maleate; Drug Antagonism; Excitatory Amino Acid Antagonists; GABA Modulators; L | 1999 |
Evaluation of inhibitory effect of diphenhydramine on benzodiazepine dependence in rats.
Topics: Acoustic Stimulation; Administration, Oral; Aggression; Animals; Anti-Anxiety Agents; Body Temperatu | 1997 |
Seizures after discontinuation of low-dose lorazepam from originally seizure-free clozapine regimen: combined effects?
Topics: Adult; Anti-Anxiety Agents; Clozapine; Dose-Response Relationship, Drug; Drug Administration Schedul | 1999 |
Lorazepam for the prevention of recurrent seizures related to alcohol.
Topics: Alcoholism; Anticonvulsants; Humans; Informed Consent; Lorazepam; Research Design; Secondary Prevent | 1999 |
Lorazepam for the prevention of recurrent seizures related to alcohol.
Topics: Alcoholism; Anticonvulsants; Humans; Lorazepam; Secondary Prevention; Seizures; Substance Withdrawal | 1999 |
Lorazepam to prevent alcohol withdrawal seizures.
Topics: Adult; Alcoholism; Anti-Anxiety Agents; Chronic Disease; Double-Blind Method; Emergency Service, Hos | 1999 |
Prehospital management of the seizure patient.
Topics: Adolescent; Adult; Airway Obstruction; Anticonvulsants; Child; Diazepam; Emergency Medical Technicia | 1999 |
Call for diazepam replacement.
Topics: Anticonvulsants; Chemical Warfare Agents; Diazepam; Humans; Lorazepam; Military Medicine; Military P | 2000 |
Effect of dopamine agonists and antagonists on the lorazepam withdrawal syndrome in rats.
Topics: Acoustic Stimulation; Aggression; Animals; Anti-Anxiety Agents; Dopamine Agonists; Dopamine Antagoni | 2000 |
Call for diazepam replacement.
Topics: Anticonvulsants; Antidotes; Chemical Warfare Agents; Diazepam; Humans; Lorazepam; Military Medicine; | 2000 |
Diazepam replacement.
Topics: Anticonvulsants; Chemical Warfare Agents; Diazepam; Humans; Lorazepam; Military Medicine; Seizures; | 2000 |
Clinical characteristics as predictors of recurrent alcohol-related seizures.
Topics: Adult; Alcohol Withdrawal Seizures; Anticonvulsants; Ethanol; Female; Hemodynamics; Humans; Lorazepa | 2000 |
Lorazepam.
Topics: Anti-Anxiety Agents; Anxiety; Asphyxia Neonatorum; Dose-Response Relationship, Drug; Female; Humans; | 2000 |
[Inhibitory processes in the cerebral cortex and the anticonvulsive action of benzodiazepine derivatives].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Cats; Cerebral Cortex; Clonazepam; Diazepam; E | 1977 |
Pharmacology of lorazepam.
Topics: Aggression; Animals; Anti-Anxiety Agents; Avoidance Learning; Behavior, Animal; Cats; Conditioning, | 1978 |
[Effects of benzodiazepines on amygdaloid kindled convulsion-differences of efficacy among diazepam, bromazepam and lorazepam-(author's transl)].
Topics: Amygdala; Animals; Benzodiazepinones; Bromazepam; Diazepam; Electric Stimulation; Lorazepam; Male; R | 1979 |
Effects of lorazepam tolerance and withdrawal on GABAA receptor operated chloride channels in mice selected for differences in ethanol withdrawal severity.
Topics: Animals; Benzodiazepines; Brain; Chloride Channels; Chlorides; Drug Tolerance; Ethanol; Infusion Pum | 1992 |
Pharmacokinetics of lorazepam in critically ill neonates with seizures.
Topics: Critical Illness; Humans; Infant, Newborn; Injections, Intravenous; Lorazepam; Seizures | 1992 |
Acute methanol poisoning: a case study.
Topics: Adult; Emergencies; Ethanol; Humans; Lorazepam; Male; Methanol; Osmolar Concentration; Pneumonia, As | 1992 |
Cyclopyrrolones, unlike some benzodiazepines, do not induce physical dependence in mice.
Topics: Animals; Azabicyclo Compounds; Carbolines; Convulsants; Diazepam; Disease Models, Animal; Flunitraze | 1990 |
Changes in seizure threshold and aggression during chronic treatment with three anticonvulsants and on drug withdrawal.
Topics: Aggression; Animals; Anticonvulsants; Lorazepam; Male; Mice; Pentylenetetrazole; Phenobarbital; Phen | 1990 |
Seizures following carotid endarterectomy.
Topics: Aged; Brain; Carotid Arteries; Electroencephalography; Endarterectomy; Female; Humans; Lorazepam; Ph | 1990 |
The role of the benzodiazepine receptor in mediating long-lasting anticonvulsant effects and the late-appearing reductions in motor activity and exploration.
Topics: Animals; Anticonvulsants; Exploratory Behavior; Lorazepam; Male; Mice; Motor Activity; Oxazepam; Pen | 1989 |
Lorazepam discontinuation promotes 'inverse agonist' effects of benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain Chemistry; Carbolines; Lorazepam; Male; Mice; S | 1989 |
Rapid sequential phenobarbital treatment of neonatal seizures.
Topics: Dose-Response Relationship, Drug; Gestational Age; Humans; Infant, Newborn; Lorazepam; Phenobarbital | 1989 |
Emergency management of seizures: an overview.
Topics: Diazepam; Emergencies; Humans; Lidocaine; Lorazepam; Phenytoin; Prodrugs; Seizures; Status Epileptic | 1989 |
Lorazepam and FG 7142 induce tolerance to the DMCM antagonistic effect of benzodiazepine receptor ligands.
Topics: Animals; Carbolines; Dose-Response Relationship, Drug; Drug Tolerance; Female; Lorazepam; Male; Mice | 1987 |
Co-existence of kindling induced by the beta-carboline, FG 7142, and tolerance to diazepam following chronic treatment in mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Carbolines; Diazepam; Drug Tolerance; Female; Kindlin | 1988 |
Rapid induction of lorazepam dependence and reversal with flumazenil.
Topics: Animals; Carbolines; Flumazenil; Lorazepam; Male; Mice; Mice, Inbred Strains; Seizures; Substance-Re | 1988 |
Generalized status myoclonicus in acute anoxic and toxic-metabolic encephalopathies.
Topics: Adult; Aged; Anticonvulsants; Brain Diseases, Metabolic; Electroencephalography; Female; Humans; Hyp | 1988 |
Lorazepam in the treatment of refractory neonatal seizures. A pilot study.
Topics: Electroencephalography; Female; Humans; Infant, Newborn; Infant, Premature, Diseases; Lorazepam; Mal | 1986 |
Lorazepam in childhood status epilepticus and serial seizures: effectiveness and tachyphylaxis.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Female; Humans; Infant; Lorazepam; Male; Seizu | 1987 |