loratadine has been researched along with Torsade de Pointes in 9 studies
Loratadine: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
loratadine : A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This report describes ventricular tachycardia, likely to have been torsade de pointes, following ingestion of the non-sedating antihistamine loratadine." | 3.71 | Ventricular tachycardia following ingestion of a commonly used antihistamine. ( Kuchar, DL; Thorburn, CW; Walker, BD, 2002) |
| "Ebastine also inhibit potassium channels, cloned human Kv 1." | 2.41 | [The effect of second generation histamine antagonists on the heart]. ( Górska, M; Grzelewska-Rzymowska, I; Pietrzkowicz, M, 2001) |
| " This paper reviews the pharmacokinetic properties of these second-generation agents and is intended to provide comparisons that help explain differences in dosing profiles and drug interactions for members of this class of drugs." | 2.40 | Pharmacokinetic overview of oral second-generation H1 antihistamines. ( Estes, KS; González, MA, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kramer, J | 1 |
| Obejero-Paz, CA | 1 |
| Myatt, G | 1 |
| Kuryshev, YA | 1 |
| Bruening-Wright, A | 1 |
| Verducci, JS | 1 |
| Brown, AM | 1 |
| Sager, PT | 1 |
| Veltri, EP | 1 |
| Atar, S | 1 |
| Freedberg, NA | 1 |
| Antonelli, D | 1 |
| Rosenfeld, T | 1 |
| Davie, C | 1 |
| Pierre-Valentin, J | 1 |
| Pollard, C | 1 |
| Standen, N | 1 |
| Mitcheson, J | 1 |
| Alexander, P | 1 |
| Thong, B | 1 |
| Katchman, AN | 1 |
| Koerner, J | 1 |
| Tosaka, T | 1 |
| Woosley, RL | 2 |
| Ebert, SN | 1 |
| González, MA | 1 |
| Estes, KS | 1 |
| Grzelewska-Rzymowska, I | 1 |
| Pietrzkowicz, M | 1 |
| Górska, M | 1 |
| Kuchar, DL | 1 |
| Walker, BD | 1 |
| Thorburn, CW | 1 |
3 reviews available for loratadine and Torsade de Pointes
| Article | Year |
|---|---|
Cardiac actions of antihistamines.
Topics: Animals; Astemizole; Cetirizine; Diphenhydramine; Drug Interactions; Histamine H1 Antagonists; Human | 1996 |
Pharmacokinetic overview of oral second-generation H1 antihistamines.
Topics: Astemizole; Blood-Brain Barrier; Cetirizine; Histamine H1 Antagonists; Humans; Loratadine; Structure | 1998 |
[The effect of second generation histamine antagonists on the heart].
Topics: Animals; Area Under Curve; Astemizole; Butyrophenones; Electrocardiography; Heart; Histamine H1 Anta | 2001 |
6 other studies available for loratadine and Torsade de Pointes
| Article | Year |
|---|---|
MICE models: superior to the HERG model in predicting Torsade de Pointes.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp T | 2013 |
Ventricular tachycardia following ingestion of a commonly used antihistamine.
Topics: Defibrillators, Implantable; Diagnostic Errors; Electrocardiography; Histamine H1 Antagonists, Non-S | 2003 |
Torsades de pointes and QT prolongation due to a combination of loratadine and amiodarone.
Topics: Aged; Amiodarone; Anti-Allergic Agents; Anti-Arrhythmia Agents; Electrocardiography; Female; Humans; | 2003 |
Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (I(Kr)) channel.
Topics: Animals; Cation Transport Proteins; Cisapride; Dose-Response Relationship, Drug; Electrophysiologic | 2004 |
Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs.
Topics: Animals; Arsenic Trioxide; Arsenicals; Cells, Cultured; Electrocardiography; ERG1 Potassium Channel; | 2006 |
Ventricular tachycardia following ingestion of a commonly used antihistamine.
Topics: Adult; Defibrillators, Implantable; Female; Histamine H1 Antagonists; Humans; Loratadine; Tachycardi | 2002 |