loratadine has been researched along with Sepsis in 1 studies
Loratadine: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
loratadine : A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here, we show that oral treatment with first-generation H1R antihistamine diphenhydramine, H2R blocker cimetidine and H3/4R blocker thioperamide impairs optimal innate immune responses in severe murine bacterial sepsis." | 3.77 | Effects of antihistamines on innate immune responses to severe bacterial infection in mice. ( Bindslev-Jensen, C; Doyle, E; Maurer, M; Metz, M; Watanabe, T; Zuberbier, T, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Metz, M | 1 |
| Doyle, E | 1 |
| Bindslev-Jensen, C | 1 |
| Watanabe, T | 1 |
| Zuberbier, T | 1 |
| Maurer, M | 1 |
1 other study available for loratadine and Sepsis
| Article | Year |
|---|---|
Effects of antihistamines on innate immune responses to severe bacterial infection in mice.
Topics: Animals; Anti-Allergic Agents; Bacterial Infections; Diphenhydramine; Histamine Antagonists; Histami | 2011 |