loratadine has been researched along with Rhinitis, Allergic in 29 studies
Loratadine: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
loratadine : A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.
Rhinitis, Allergic: An inflammation of the NASAL MUCOSA triggered by ALLERGENS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate, numerically, nasal airflow changes provided by a single dose of loratadine-pseudoephedrine tablet (LP) and fluticasone propionate nasal spray (FP) in participants experiencing allergic rhinitis symptoms, including nasal congestion." | 9.41 | Comparative nasal airflow with loratadine-pseudoephedrine and fluticasone nasal spray for allergic rhinitis. ( Adams, DE; Ellis, AK; Ng, CC; Romaikin, D; Steacy, LM; Stevens, DA; Walker, TJ, 2021) |
| "The work aimed to develop a co-loaded loratadine and sulpiride nasal nanoemulsion for allergic rhinitis management." | 8.02 | A novel nasal co-loaded loratadine and sulpiride nanoemulsion with improved downregulation of TNF-α, TGF-β and IL-1 in rabbit models of ovalbumin-induced allergic rhinitis. ( Badawi, AM; Elrehany, M; Maher, SA; Mansour, HF; Mohamad, SA; Safwat, MA, 2021) |
| "This experiment was performed to explore the effect of oral desloratadine citrate disodium combined with physiological seawater nasal irrigation in the treatment of intermittent allergic rhinitis and its effect on serum inflammatory factors and peripheral blood Th1 and Th2." | 7.96 | Effects of oral desloratadine citrate disodium combined with physiological seawater nasal irrigation on IgE levels, IL-4, IL-6, IL-13 and IFN-γ expression and treatment of intermittent allergic rhinitis. ( Li, W; Zhang, Y, 2020) |
| "We think that berberine and coenzyme Q10 can usefully be employed as therapy due to their antioxidant and anti-inflammatory effects in an experimentally induced allergic rhinitis model." | 7.88 | The ameliorative effect of berberine and coenzyme Q10 in an ovalbumin-induced allergic rhinitis model. ( Kandemir, FM; Kilic, K; Kucukler, S; Saglam, YS; Sahin, A; Sakat, MS; Yildirim, S, 2018) |
| "The aim of this study was to determine whether there were differences in health-related quality of life of patients with allergic rhinitis treated with bilastine 20 mg compared to those treated with loratadine 10 mg." | 7.85 | Quality of life in patients with allergic rhinitis: a clinical trial comparing the use of bilastine versus loratadine. ( da Silva, J; Dos Santos, K; Locks, RB, 2017) |
| "Desloratadine is a biologically active metabolite of loratadine which is indicated for the treatment of allergic rhinitis." | 7.83 | The role of endothelin-1 and endothelin receptor antagonists in allergic rhinitis inflammation: ovalbumin-induced rat model. ( Halici, Z; Kose, D; Polat, E; Tatar, A; Yayla, M; Yoruk, O, 2016) |
| "Desloratadine is a biologically active metabolite of second-generation antihistamine loratadine." | 6.49 | Safety evaluation of desloratadine in allergic rhinitis. ( González-Núñez, V; Mullol, J; Valero, A, 2013) |
| "Desloratadine treatment alleviated AR symptoms, decreased serum level of OVA-specific IgE and IL-17 in AR rats." | 5.56 | Desloratadine Ameliorates Olfactory Disorder and Suppresses AMPA Receptor GluA1 Expression in Allergic Rhinitis Rat. ( Huang, Y; Jiang, X; Jiang, Y; Li, N; Li, S; Li, Z; Zhang, J; Zhang, N; Zhang, X; Zhao, H, 2020) |
| "Desloratadine is a novel, long-acting inhibitor of histamine." | 5.42 | Effects of desloratadine citrate disodium injection on rat models of ovalbumin-induced allergic rhinitis: involvement of T-cell responses modulation. ( Ghosh, A; He, G; Jie, Q; Wu, Y; Yuan, X, 2015) |
| "To evaluate, numerically, nasal airflow changes provided by a single dose of loratadine-pseudoephedrine tablet (LP) and fluticasone propionate nasal spray (FP) in participants experiencing allergic rhinitis symptoms, including nasal congestion." | 5.41 | Comparative nasal airflow with loratadine-pseudoephedrine and fluticasone nasal spray for allergic rhinitis. ( Adams, DE; Ellis, AK; Ng, CC; Romaikin, D; Steacy, LM; Stevens, DA; Walker, TJ, 2021) |
| " Loratadine decreased nasal obstruction in allergic rhinitis patients with acute rhinosinusitis (mean difference = -0." | 4.98 | Antihistamines for treating rhinosinusitis: systematic review and meta-analysis of randomised controlled studies. ( Chitsuthipakorn, W; Khattiyawittayakun, L; Seresirikachorn, K; Snidvongs, K, 2018) |
| "Current medications to treat allergic rhinitis (AR) include antihistamines, corticosteroids, and anti-leukotrienes." | 4.12 | The Effects of Combined Therapeutic Protocol on Allergic Rhinitis Symptoms and Molecular Determinants. ( Athari, SS; Hassanpour, F; Mehrabi Nasab, E; Shen, Y, 2022) |
| "The work aimed to develop a co-loaded loratadine and sulpiride nasal nanoemulsion for allergic rhinitis management." | 4.02 | A novel nasal co-loaded loratadine and sulpiride nanoemulsion with improved downregulation of TNF-α, TGF-β and IL-1 in rabbit models of ovalbumin-induced allergic rhinitis. ( Badawi, AM; Elrehany, M; Maher, SA; Mansour, HF; Mohamad, SA; Safwat, MA, 2021) |
| "This experiment was performed to explore the effect of oral desloratadine citrate disodium combined with physiological seawater nasal irrigation in the treatment of intermittent allergic rhinitis and its effect on serum inflammatory factors and peripheral blood Th1 and Th2." | 3.96 | Effects of oral desloratadine citrate disodium combined with physiological seawater nasal irrigation on IgE levels, IL-4, IL-6, IL-13 and IFN-γ expression and treatment of intermittent allergic rhinitis. ( Li, W; Zhang, Y, 2020) |
| "We think that berberine and coenzyme Q10 can usefully be employed as therapy due to their antioxidant and anti-inflammatory effects in an experimentally induced allergic rhinitis model." | 3.88 | The ameliorative effect of berberine and coenzyme Q10 in an ovalbumin-induced allergic rhinitis model. ( Kandemir, FM; Kilic, K; Kucukler, S; Saglam, YS; Sahin, A; Sakat, MS; Yildirim, S, 2018) |
| "The aim of this study was to determine whether there were differences in health-related quality of life of patients with allergic rhinitis treated with bilastine 20 mg compared to those treated with loratadine 10 mg." | 3.85 | Quality of life in patients with allergic rhinitis: a clinical trial comparing the use of bilastine versus loratadine. ( da Silva, J; Dos Santos, K; Locks, RB, 2017) |
| "Desloratadine is a biologically active metabolite of loratadine which is indicated for the treatment of allergic rhinitis." | 3.83 | The role of endothelin-1 and endothelin receptor antagonists in allergic rhinitis inflammation: ovalbumin-induced rat model. ( Halici, Z; Kose, D; Polat, E; Tatar, A; Yayla, M; Yoruk, O, 2016) |
| " Desloratadine, a descarboethoxy derivative of loratadine, is a second generation antihistaminic drug approved for usage in allergic rhinitis among paediatric population and is available in markets as suspension." | 3.79 | Optimization and evaluation of desloratadine oral strip: an innovation in paediatric medication. ( Kaur, M; Singh, H; Verma, H, 2013) |
| "To investigate the effect of drug treatment combined with psychological intervention on mental disorders in patients with persistent moderate-severe allergic rhinitis." | 3.01 | Improvement in Psychological Condition of Patients With Persistent Moderate-Severe Allergic Rhinitis by Drug Therapy Combined With Psychological Intervention. ( Di, LL; Kang, ZP; Liu, J; Peng, XB; Tan, Y; Wang, LX; Yang, ZC, 2021) |
| "Desloratadine is a biologically active metabolite of second-generation antihistamine loratadine." | 2.49 | Safety evaluation of desloratadine in allergic rhinitis. ( González-Núñez, V; Mullol, J; Valero, A, 2013) |
| "Desloratadine treatment alleviated AR symptoms, decreased serum level of OVA-specific IgE and IL-17 in AR rats." | 1.56 | Desloratadine Ameliorates Olfactory Disorder and Suppresses AMPA Receptor GluA1 Expression in Allergic Rhinitis Rat. ( Huang, Y; Jiang, X; Jiang, Y; Li, N; Li, S; Li, Z; Zhang, J; Zhang, N; Zhang, X; Zhao, H, 2020) |
| "Desloratadine is a novel, long-acting inhibitor of histamine." | 1.42 | Effects of desloratadine citrate disodium injection on rat models of ovalbumin-induced allergic rhinitis: involvement of T-cell responses modulation. ( Ghosh, A; He, G; Jie, Q; Wu, Y; Yuan, X, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 20 (68.97) | 24.3611 |
| 2020's | 9 (31.03) | 2.80 |
| Authors | Studies |
|---|---|
| He, M | 1 |
| Qin, W | 1 |
| Qin, Z | 1 |
| Zhao, C | 1 |
| Shen, Y | 1 |
| Mehrabi Nasab, E | 1 |
| Hassanpour, F | 1 |
| Athari, SS | 1 |
| Wang, LX | 1 |
| Yang, ZC | 1 |
| Kang, ZP | 1 |
| Di, LL | 1 |
| Tan, Y | 1 |
| Peng, XB | 1 |
| Liu, J | 2 |
| Li, S | 2 |
| Zhang, X | 1 |
| Li, Z | 1 |
| Jiang, X | 1 |
| Zhang, N | 1 |
| Zhang, J | 1 |
| Huang, Y | 1 |
| Zhao, H | 2 |
| Jiang, Y | 1 |
| Li, N | 1 |
| Yamprasert, R | 1 |
| Chanvimalueng, W | 1 |
| Mukkasombut, N | 1 |
| Itharat, A | 1 |
| Zhang, Y | 2 |
| Li, W | 1 |
| Liu, X | 2 |
| Ren, Y | 1 |
| Yang, H | 1 |
| Sun, X | 1 |
| Huang, H | 1 |
| Mohamad, SA | 1 |
| Safwat, MA | 1 |
| Elrehany, M | 1 |
| Maher, SA | 1 |
| Badawi, AM | 1 |
| Mansour, HF | 1 |
| Ng, CC | 1 |
| Romaikin, D | 1 |
| Steacy, LM | 1 |
| Stevens, DA | 1 |
| Walker, TJ | 1 |
| Adams, DE | 1 |
| Ellis, AK | 1 |
| Seresirikachorn, K | 1 |
| Khattiyawittayakun, L | 1 |
| Chitsuthipakorn, W | 1 |
| Snidvongs, K | 1 |
| Tanticharoenwiwat, P | 1 |
| Kulalert, P | 1 |
| Dechatiwongse Na Ayudhya, T | 1 |
| Koontongkaew, S | 1 |
| Jiratchariyakul, W | 1 |
| Soawakontha, R | 1 |
| Booncong, P | 1 |
| Poachanukoon, O | 1 |
| Schaefer, M | 1 |
| Sahin, T | 1 |
| Berstecher, B | 1 |
| Liu, Y | 2 |
| Ye, XJ | 1 |
| Zhao, CL | 1 |
| Ji, Q | 1 |
| Qiao, Y | 1 |
| Liu, T | 1 |
| Zhang, KJ | 1 |
| Feng, Y | 1 |
| Li, KT | 1 |
| Jia, MH | 1 |
| Chen, XY | 1 |
| Liao, ZS | 1 |
| Ji, XQ | 1 |
| Zhang, NK | 1 |
| Qu, J | 1 |
| Liu, C | 1 |
| Lian, HH | 1 |
| Wang, XD | 1 |
| Zhi, N | 1 |
| Sakat, MS | 1 |
| Kilic, K | 1 |
| Kandemir, FM | 1 |
| Yildirim, S | 1 |
| Sahin, A | 1 |
| Kucukler, S | 1 |
| Saglam, YS | 1 |
| González-Núñez, V | 1 |
| Valero, A | 1 |
| Mullol, J | 1 |
| Singh, H | 1 |
| Kaur, M | 1 |
| Verma, H | 1 |
| Kumria, R | 1 |
| Nair, AB | 1 |
| Al-Dhubiab, BE | 1 |
| Lu, Y | 1 |
| Yin, M | 1 |
| Cheng, L | 1 |
| Yuan, X | 1 |
| Ghosh, A | 1 |
| Jie, Q | 2 |
| He, G | 2 |
| Wu, Y | 2 |
| Tatar, A | 2 |
| Parlak, SN | 1 |
| Yayla, M | 2 |
| Ugan, RA | 1 |
| Polat, E | 2 |
| Halici, Z | 2 |
| Chen, M | 1 |
| Xu, S | 1 |
| Zhou, P | 1 |
| Kennedy, DW | 1 |
| Kose, D | 1 |
| Yoruk, O | 1 |
| Sun, Y | 1 |
| Ye, Y | 1 |
| Nie, W | 1 |
| Bai, W | 1 |
| Wang, F | 1 |
| Han, M | 1 |
| He, L | 1 |
| Locks, RB | 1 |
| Dos Santos, K | 1 |
| da Silva, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparative Study of Efficacy and Adverse Effects of Ginger Extract and Loratadine for Treatment of Allergic Rhinitis Patients (Clinical Trial Phase II)[NCT02576808] | Phase 2 | 80 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| A Double-Blind Placebo-Controlled Crossover Study to Evaluate Objective Changes in Nasal Airflow of Loratadine/Pseudoephedrine Tablet and Fluticasone Propionate Nasal Spray in Subjects Following Allergen Exposure in an Environmental Exposure Unit[NCT03443843] | Phase 4 | 82 participants (Actual) | Interventional | 2018-02-21 | Completed | ||
| Effect Comparison of Acupuncture Combined With Moxibustion and Loratadine for Perennial Allergic Rhinitis: a Randomized Controlled Trial[NCT02339714] | Phase 2 | 98 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for loratadine and Rhinitis, Allergic
| Article | Year |
|---|---|
Acupuncture for allergic rhinitis: a systematic review and meta-analysis.
Topics: Acupuncture Therapy; Adolescent; Adult; Cetirizine; Child; Humans; Loratadine; Quality of Life; Rhin | 2022 |
Antihistamines for treating rhinosinusitis: systematic review and meta-analysis of randomised controlled studies.
Topics: Histamine Antagonists; Humans; Loratadine; Randomized Controlled Trials as Topic; Rhinitis, Allergic | 2018 |
Safety evaluation of desloratadine in allergic rhinitis.
Topics: Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Rhinitis, Allergic; Rhinitis, Allergic, | 2013 |
[Meta-analysis of leukotriene receptor antagonist montelukast in the treatment of allergic rhinitis].
Topics: Acetates; Cyclopropanes; Drug Therapy, Combination; Humans; Leukotriene Antagonists; Loratadine; Nos | 2014 |
10 trials available for loratadine and Rhinitis, Allergic
| Article | Year |
|---|---|
Improvement in Psychological Condition of Patients With Persistent Moderate-Severe Allergic Rhinitis by Drug Therapy Combined With Psychological Intervention.
Topics: Adolescent; Adult; Anti-Allergic Agents; Anxiety; Cognitive Behavioral Therapy; Combined Modality Th | 2021 |
Ginger extract versus Loratadine in the treatment of allergic rhinitis: a randomized controlled trial.
Topics: Adult; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male | 2020 |
Clinical Efficacy of Vitamin D3 Adjuvant Therapy in Allergic Rhinitis: A Randomized Controlled Trial.
Topics: Adjuvants, Pharmaceutic; Adolescent; Adult; Cholecalciferol; Drug Therapy, Combination; Eosinophils; | 2020 |
Comparative nasal airflow with loratadine-pseudoephedrine and fluticasone nasal spray for allergic rhinitis.
Topics: Administration, Intranasal; Adult; Anti-Allergic Agents; Cross-Over Studies; Double-Blind Method; Dr | 2021 |
Inhibitory effect of Phlai capsules on skin test responses among allergic rhinitis patients: a randomized, three-way crossover study.
Topics: Adult; Allergens; Animals; Anti-Allergic Agents; Cross-Over Studies; Double-Blind Method; Histamine; | 2017 |
Why do open-label placebos work? A randomized controlled trial of an open-label placebo induction with and without extended information about the placebo effect in allergic rhinitis.
Topics: Adolescent; Adult; Anti-Allergic Agents; Cetirizine; Female; Humans; Loratadine; Male; Placebo Effec | 2018 |
[The effect of combined therapy on seasonal allergic rhinitis].
Topics: Administration, Intranasal; Budesonide; Double-Blind Method; Glucocorticoids; Humans; Leukotriene An | 2016 |
[Effect of nasal glucocorticoid combined with loratadine or montelukast on allergic rhinitis].
Topics: Acetates; Administration, Intranasal; Anti-Allergic Agents; Cyclopropanes; Double-Blind Method; Drug | 2017 |
Qingfeijianpi therapy for persistent allergic rhinitis: A randomized, positive-controlled clinical trial.
Topics: Adult; Anti-Allergic Agents; Drugs, Chinese Herbal; Female; Humans; Loratadine; Male; Middle Aged; R | 2018 |
Efficacy and safety of using a warming needle for persistent allergic rhinitis: study protocol for a randomized controlled trial.
Topics: Acupuncture Therapy; Adolescent; Adult; Anti-Allergic Agents; China; Clinical Protocols; Female; Hot | 2016 |
15 other studies available for loratadine and Rhinitis, Allergic
| Article | Year |
|---|---|
The Effects of Combined Therapeutic Protocol on Allergic Rhinitis Symptoms and Molecular Determinants.
Topics: Allergens; Animals; Caspase 1; Fluticasone; Histamine; Immunoglobulin E; Leukotriene C4; Loratadine; | 2022 |
Desloratadine Ameliorates Olfactory Disorder and Suppresses AMPA Receptor GluA1 Expression in Allergic Rhinitis Rat.
Topics: Animals; Disease Models, Animal; Histamine H1 Antagonists, Non-Sedating; Immunoglobulin E; Interleuk | 2020 |
Effects of oral desloratadine citrate disodium combined with physiological seawater nasal irrigation on IgE levels, IL-4, IL-6, IL-13 and IFN-γ expression and treatment of intermittent allergic rhinitis.
Topics: Adult; CD4-Positive T-Lymphocytes; Citric Acid; Female; Humans; Immunoglobulin E; Interferon-gamma; | 2020 |
A novel nasal co-loaded loratadine and sulpiride nanoemulsion with improved downregulation of TNF-α, TGF-β and IL-1 in rabbit models of ovalbumin-induced allergic rhinitis.
Topics: Administration, Intranasal; Animals; Calorimetry, Differential Scanning; Disease Models, Animal; Dop | 2021 |
[Allergic rhinitis management:environment control and patient education].
Topics: Administration, Intranasal; Administration, Oral; Anti-Allergic Agents; Bifidobacterium; Clostridium | 2017 |
[To investigate the correlation of nasal secretions of eosinophils and lung function after the treatment of budesonide in the allergic rhinitis patients].
Topics: Anti-Allergic Agents; Anti-Inflammatory Agents; Budesonide; Case-Control Studies; Eosinophils; Human | 2017 |
The ameliorative effect of berberine and coenzyme Q10 in an ovalbumin-induced allergic rhinitis model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Berberine; Disease Models, Animal; Histamine H1 Ant | 2018 |
Optimization and evaluation of desloratadine oral strip: an innovation in paediatric medication.
Topics: Chemistry, Pharmaceutical; Child; Drug Carriers; Humans; Loratadine; Materials Testing; Microscopy, | 2013 |
Loratidine buccal films for allergic rhinitis: development and evaluation.
Topics: Adhesiveness; Administration, Buccal; Animals; Chemistry, Pharmaceutical; Dosage Forms; Histamine H1 | 2014 |
Effects of desloratadine citrate disodium injection on rat models of ovalbumin-induced allergic rhinitis: involvement of T-cell responses modulation.
Topics: Allergens; Animals; Cell Adhesion Molecules; Citrates; Cytokines; Disease Models, Animal; Gene Expre | 2015 |
Effects of allergic rhinitis and desloratadine on the submandibular gland in a rat allergy model.
Topics: Animals; Disease Models, Animal; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; | 2015 |
Desloratadine citrate disodium injection, a potent histamine H(1) receptor antagonist, inhibits chemokine production in ovalbumin-induced allergic rhinitis guinea pig model and histamine-induced human nasal epithelial cells via inhibiting the ERK1/2 and N
Topics: Animals; Anti-Allergic Agents; Cells, Cultured; Chemokine CCL2; Chemokine CCL5; Chemokines; Disease | 2015 |
EDITORIAL.
Topics: Animals; Carcinogenesis; Chronic Disease; Diagnosis, Differential; Histamine Antagonists; Humans; Lo | 2015 |
The role of endothelin-1 and endothelin receptor antagonists in allergic rhinitis inflammation: ovalbumin-induced rat model.
Topics: Animals; Bosentan; Disease Models, Animal; Down-Regulation; Endothelin Receptor Antagonists; Endothe | 2016 |
Quality of life in patients with allergic rhinitis: a clinical trial comparing the use of bilastine versus loratadine.
Topics: Adolescent; Adult; Anti-Allergic Agents; Benzimidazoles; Brazil; Double-Blind Method; Female; Humans | 2017 |