Page last updated: 2024-10-30

loratadine and Pruritus

loratadine has been researched along with Pruritus in 32 studies

Loratadine: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
loratadine : A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.

Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.

Research Excerpts

ExcerptRelevanceReference
"To compare the efficacy and side effects of gabapentin and desloratadine in patients with dialysis pruritus."9.16Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin. ( Barrón, B; Lauxmann, JE; Marquez, D; Martinatto, C; Novoa, PA; Orías, M; Peixoto, AJ; Ramonda, C; Romero, CA; Vukelic, VL, 2012)
"Levocetirizine led to a significantly greater decrease in pruritus severity than desloratadine over the first treatment week; mean pruritus severity scores of 1."9.14Comparison of the efficacy of levocetirizine 5 mg and desloratadine 5 mg in chronic idiopathic urticaria patients. ( Finlay, AY; Guillet, G; Hauptmann, P; Jian, AM; Kapp, A; Maurer, M; Potter, PC, 2009)
"Our data show a tendency to suppressive effect of montelukast on flare and itching but not on wheal which is basic for SPT interpretation."9.12The effect of montelukast (10mg daily) and loratadine (10mg daily) on wheal, flare and itching reactions in skin prick tests. ( Górski, P; Kuna, P; Kupczyk, M; Kupryś, I, 2007)
"Desloratadine treatment was associated with significant improvements compared with placebo in pruritus scores and in the size of the largest wheals as early as day 1."9.12Efficacy and safety of desloratadine in adults with chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled, multicenter trial. ( Auquier, P; Dreyfus, I; Grob, JJ; Ortonne, JP, 2007)
"To compare the efficacy and tolerance of naltrexone and loratadine in uremic pruritus."9.11A comparative study on the effects of naltrexone and loratadine on uremic pruritus. ( Clèdes, J; Legroux-Crespel, E; Misery, L, 2004)
" Both desloratadine alone and desloratadine plus montelukast administered once daily yielded improvements with respect to the baseline assessment as regards pruritus, number of separate episodes, size and number of weals, visual analogue score and patients' quality of life and with respect to the placebo group both in the active treatment period and in the run-out period."9.11Desloratadine in combination with montelukast in the treatment of chronic urticaria: a randomized, double-blind, placebo-controlled study. ( Colanardi, MC; Ferrannini, A; Nettis, E; Paradiso, MT, 2004)
"To compare the clinical efficacy and safety of mizolastine with loratadine and placebo in patients with chronic idiopathic urticaria (CIU)."9.09Efficacy and safety of mizolastine 10 mg in a placebo-controlled comparison with loratadine in chronic idiopathic urticaria: results of the MILOR Study. ( Dubertret, L; Murrieta Aguttes, M; Tonet, J, 1999)
"Desloratadine was superior to placebo in controlling pruritus and total symptoms after the first dose and maintained this superiority to the end of the study."9.09Once-daily desloratadine improves the signs and symptoms of chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled study. ( Bronsky, E; Gauger, A; Hein, R; Miller, B; Ring, J, 2001)
"The aim of the study was to assess the therapeutic efficacy of loratadine on pruritus in patients with atopic dermatitis, considering the patients' sensation of itch."9.07Therapeutic effect of loratadine on pruritus in patients with atopic dermatitis. A multi-crossover-designed study. ( Fagertun, HE; Langeland, T; Larsen, S, 1994)
" Desloratadine therapy significantly reduced nasal and ocular symptom severity, itching and wheals, and sleep and activity disruption (p < 0."8.86Safety and efficacy of desloratadine in subjects with seasonal allergic rhinitis or chronic urticaria: results of four postmarketing surveillance studies. ( Bachert, C; Maurer, M, 2010)
"Loratadine was safe and well tolerated with sedation and dry mouth similar to placebo and significantly less than hydroxyzine."6.67Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria. ( Bernstein, DI; Cuss, F; Danzig, MR; Fox, RW; Garvin, PR; Grabiec, SV; Honsinger, RW; Kalivas, JT; Katz, HI; Monroe, EW, 1992)
"To compare the efficacy and side effects of gabapentin and desloratadine in patients with dialysis pruritus."5.16Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin. ( Barrón, B; Lauxmann, JE; Marquez, D; Martinatto, C; Novoa, PA; Orías, M; Peixoto, AJ; Ramonda, C; Romero, CA; Vukelic, VL, 2012)
"Levocetirizine led to a significantly greater decrease in pruritus severity than desloratadine over the first treatment week; mean pruritus severity scores of 1."5.14Comparison of the efficacy of levocetirizine 5 mg and desloratadine 5 mg in chronic idiopathic urticaria patients. ( Finlay, AY; Guillet, G; Hauptmann, P; Jian, AM; Kapp, A; Maurer, M; Potter, PC, 2009)
"Our data show a tendency to suppressive effect of montelukast on flare and itching but not on wheal which is basic for SPT interpretation."5.12The effect of montelukast (10mg daily) and loratadine (10mg daily) on wheal, flare and itching reactions in skin prick tests. ( Górski, P; Kuna, P; Kupczyk, M; Kupryś, I, 2007)
"Desloratadine treatment was associated with significant improvements compared with placebo in pruritus scores and in the size of the largest wheals as early as day 1."5.12Efficacy and safety of desloratadine in adults with chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled, multicenter trial. ( Auquier, P; Dreyfus, I; Grob, JJ; Ortonne, JP, 2007)
"This study was conducted to assess the pharmacodynamic effects (ie, inhibition of wheal response to cutaneous histamine challenge, and subjective assessments of itching, flare, and pain) and tolerability of the fast-dissolving 20-mg ebastine tablet formulation compared with desloratadine 5-mg capsule and placebo."5.12Comparison of inhibition of cutaneous histamine reaction of ebastine fast-dissolving tablet (20 mg) versus desloratadine capsule (5 mg): a randomized, double-blind, double-dummy, placebo-controlled, three-period crossover study in healthy, nonatopic adult ( Antonijoan, R; Barbanoj, MJ; Esbrí, R; Fortea, J; García-Gea, C; Pérez, J; Puntes, M; Serra, C, 2007)
"To compare the efficacy and tolerance of naltrexone and loratadine in uremic pruritus."5.11A comparative study on the effects of naltrexone and loratadine on uremic pruritus. ( Clèdes, J; Legroux-Crespel, E; Misery, L, 2004)
" Both desloratadine alone and desloratadine plus montelukast administered once daily yielded improvements with respect to the baseline assessment as regards pruritus, number of separate episodes, size and number of weals, visual analogue score and patients' quality of life and with respect to the placebo group both in the active treatment period and in the run-out period."5.11Desloratadine in combination with montelukast in the treatment of chronic urticaria: a randomized, double-blind, placebo-controlled study. ( Colanardi, MC; Ferrannini, A; Nettis, E; Paradiso, MT, 2004)
"Olopatadine hydrochloride is one of the second-generation nonsedating antihistamines that are used for treating allergic disorders such as urticaria, rhinitis, and atopic dermatitis."5.10Rapid effects of olopatadine hydrochloride on the histamine-induced skin responses. ( Furue, M; Koga, T; Morita, K; Moroi, Y; Urabe, K, 2002)
"This comparative study in mosquito-bite-sensitive adults shows that cetirizine and ebastine decrease significantly whealing and accompanying pruritus, and that cetirizine seems to be the most effective against pruritus."5.10Comparison of cetirizine, ebastine and loratadine in the treatment of immediate mosquito-bite allergy. ( Burri, P; Karppinen, A; Kautiainen, H; Petman, L; Reunala, T, 2002)
"To compare the clinical efficacy and safety of mizolastine with loratadine and placebo in patients with chronic idiopathic urticaria (CIU)."5.09Efficacy and safety of mizolastine 10 mg in a placebo-controlled comparison with loratadine in chronic idiopathic urticaria: results of the MILOR Study. ( Dubertret, L; Murrieta Aguttes, M; Tonet, J, 1999)
"Desloratadine was superior to placebo in controlling pruritus and total symptoms after the first dose and maintained this superiority to the end of the study."5.09Once-daily desloratadine improves the signs and symptoms of chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled study. ( Bronsky, E; Gauger, A; Hein, R; Miller, B; Ring, J, 2001)
"The aim of the study was to assess the therapeutic efficacy of loratadine on pruritus in patients with atopic dermatitis, considering the patients' sensation of itch."5.07Therapeutic effect of loratadine on pruritus in patients with atopic dermatitis. A multi-crossover-designed study. ( Fagertun, HE; Langeland, T; Larsen, S, 1994)
" However, fexofenadine probably leads to a small improvement in patient-assessed pruritus, with probably no significant difference in the amount of treatment used to prevent eczema flares."5.01Oral H1 antihistamines as 'add-on' therapy to topical treatment for eczema. ( Apfelbacher, CJ; Böhmer, MM; Carter, B; Jupiter, A; Matterne, U; Weisshaar, E, 2019)
" Desloratadine therapy significantly reduced nasal and ocular symptom severity, itching and wheals, and sleep and activity disruption (p < 0."4.86Safety and efficacy of desloratadine in subjects with seasonal allergic rhinitis or chronic urticaria: results of four postmarketing surveillance studies. ( Bachert, C; Maurer, M, 2010)
"Montelukast is a leukotriene receptor antagonist recently approved for the treatment of seasonal allergic rhinitis (SAR)."2.71Fluticasone propionate aqueous nasal spray provided significantly greater improvement in daytime and nighttime nasal symptoms of seasonal allergic rhinitis compared with montelukast. ( Arastu, R; Baidoo, CA; Faris, MA; Howland, WC; Klein, KC; Philpot, EE; Ratner, PH; Rickard, KA, 2003)
"Levocetirizine was used as a comparator."2.71Comparison of the effects of desloratadine and levocetirizine on histamine-induced wheal, flare and itch in human skin. ( Boutsiouki, P; Church, MK; Clough, GF; Denham, KJ, 2003)
"Escin has satisfactory effect in treating pruritus caused by blood stasis and wind-dryness."2.71[Clinical effect of escin on patients with cutaneous pruritus caused by blood stasis and wind-dryness]. ( Fan, B; Gu, DQ; Li, B; Li, FL; Xu, R; Xu, WB; Zhang, M; Zhou, M; Zhou, R, 2004)
"Loratadine was safe and well tolerated with sedation and dry mouth similar to placebo and significantly less than hydroxyzine."2.67Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria. ( Bernstein, DI; Cuss, F; Danzig, MR; Fox, RW; Garvin, PR; Grabiec, SV; Honsinger, RW; Kalivas, JT; Katz, HI; Monroe, EW, 1992)
"Itching is one of the major clinical symptoms in atopic dermatitis (AD) and complicates the management of this pathological condition."1.33Spontaneous scratching behaviour in DS-Nh mice as a possible model for pruritus in atopic dermatitis. ( Arimura, A; Asakawa, M; Deguchi, M; Hikita, I; Hirasawa, T; Horikawa, T; Matsutani, T; Oku, H; Yoshioka, T, 2006)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (21.88)18.2507
2000's16 (50.00)29.6817
2010's8 (25.00)24.3611
2020's1 (3.13)2.80

Authors

AuthorsStudies
Solinski, HJ1
Dranchak, P1
Oliphant, E1
Gu, X1
Earnest, TW1
Braisted, J1
Inglese, J1
Hoon, MA1
Gong, Y1
Zhang, Y1
Zhou, S1
Chen, D1
Zhong, S1
Qu, J1
Liang, X1
Matterne, U1
Böhmer, MM1
Weisshaar, E1
Jupiter, A1
Carter, B1
Apfelbacher, CJ1
Meijer, JM1
van Dalen, T1
van der Wal, B1
Potter, PC1
Kapp, A1
Maurer, M2
Guillet, G1
Jian, AM1
Hauptmann, P1
Finlay, AY1
Grubbe, RE1
Lumry, WR1
Anolik, R1
Bachert, C1
Hornby, SA1
Schlosburg, JE1
O'Neal, ST1
Conrad, DH1
Lichtman, AH1
Mulliez, P1
Mbassi Fouda, FL1
Roy Saint-Georges, F1
Paniz-Mondolfi, AE1
Pérez-Alvarez, AM1
Lundberg, U1
Fornés, L1
Reyes-Jaimes, O1
Hernández-Pérez, M1
Hossler, E1
Marquez, D1
Ramonda, C1
Lauxmann, JE1
Romero, CA1
Vukelic, VL1
Martinatto, C1
Barrón, B1
Novoa, PA1
Peixoto, AJ1
Orías, M1
Morita, K1
Koga, T1
Moroi, Y1
Urabe, K1
Furue, M1
Ratner, PH1
Howland, WC1
Arastu, R1
Philpot, EE1
Klein, KC1
Baidoo, CA1
Faris, MA1
Rickard, KA1
Denham, KJ1
Boutsiouki, P1
Clough, GF1
Church, MK1
Legroux-Crespel, E1
Clèdes, J1
Misery, L1
Nucera, E1
Schiavino, D1
Pollastrini, E1
Manna, R1
Di Lillo, M1
De Lillo, M1
Buonomo, A1
Roncallo, C1
Patriarca, G1
Nettis, E1
Colanardi, MC1
Paradiso, MT1
Ferrannini, A1
Li, FL1
Xu, R1
Zhou, R1
Fan, B1
Zhou, M1
Xu, WB1
Gu, DQ1
Zhang, M1
Li, B1
Kupczyk, M1
Kupryś, I1
Górski, P1
Kuna, P1
Yoshioka, T1
Hikita, I1
Asakawa, M1
Hirasawa, T1
Deguchi, M1
Matsutani, T1
Oku, H1
Horikawa, T1
Arimura, A1
Ortonne, JP1
Grob, JJ1
Auquier, P1
Dreyfus, I1
Antonijoan, R1
García-Gea, C1
Puntes, M1
Pérez, J1
Esbrí, R1
Serra, C1
Fortea, J1
Barbanoj, MJ1
Langeland, T1
Fagertun, HE1
Larsen, S1
Day, JH1
Briscoe, MP1
Clark, RH1
Ellis, AK1
Gervais, P1
Dubertret, L1
Murrieta Aguttes, M1
Tonet, J1
Ring, J1
Hein, R1
Gauger, A1
Bronsky, E1
Miller, B1
Karppinen, A1
Kautiainen, H1
Petman, L1
Burri, P1
Reunala, T1
Monroe, EW1
Bernstein, DI1
Fox, RW1
Grabiec, SV1
Honsinger, RW1
Kalivas, JT1
Katz, HI1
Cuss, F1
Danzig, MR1
Garvin, PR1
Abu Shareeah, AM1
Frølund, L1
Paul, E1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Aprepitant vs. Desloratadine in Non-small Cell Lung Cancer Patients With Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Related Pruritus: A Prospective, Randomized Control, Double-blinded, Phase II Clinical Trial[NCT02646020]Phase 2138 participants (Actual)Interventional2015-12-31Completed
The Addition of Montelukast to Fluticasone in the Treatment of Perennial Allergic Rhinitis[NCT00119015]Phase 4102 participants (Actual)Interventional2005-07-31Terminated (stopped due to Difficulty in recruitment)
Effectiveness of Montelukast Versus Intranasal Fluticasone Propionate in the Management of Allergic Rhinitis Among Children 02 to 05 Years of Age[NCT04957927]Phase 460 participants (Anticipated)Interventional2020-12-12Recruiting
Nasal Ocular Reflexes Contribute to Eye Symptoms in Patients With Allergic Rhinitis[NCT00117832]20 participants Interventional2005-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline in Other Symptom Score Over 2 Week Randomized Treatment Period

"Patients recorded the severity of other symptoms, including itchy nose/eyes and post-nasal drip, twice a day on a scale from 0 to 3 (0 = no symptoms, 1 = mild, 2 = moderate, and 3 = severe). The other symptom score was calculated as the sum of all scores for morning and evening recordings with a range of 0 to 6.~The baseline symptom score used in the analysis was the average of the symptom scores from the last 5 days of fluticasone propionate therapy prior to randomized treatment period.~The change from baseline for each subsequent day of treatment was then calculated for each subject. So that each subject only had one observation, the average of these changes was calculated for each subject, and this summary measure was used in the analysis comparing the two treatment groups. We report the median and full range of these average changes for each group.~A negative value indicates an improvement in symptoms." (NCT00119015)
Timeframe: Baseline and 2 weeks

Interventionunits on a scale (Median)
Fluticasone Propionate + Montelukast-0.24
Fluticasone Propionate + Placebo-0.14

Change From Baseline in Runny Nose Symptom Score Over 2 Week Randomized Treatment Period

"Patients recorded the severity of runny nose twice a day on a scale from 0 to 3 (0 = no symptoms, 1 = mild, 2 = moderate, and 3 = severe). The runny nose symptom score was calculated as the sum of all scores for morning and evening recordings with a range of 0 to 6.~The baseline symptom score used in the analysis was the average of the symptom scores from the last 5 days of fluticasone propionate therapy prior to randomized treatment period.~The change from baseline for each subsequent day of treatment was then calculated for each subject. So that each subject only had one observation, the average of these changes was calculated for each subject, and this summary measure was used in the analysis comparing the two treatment groups. We report the median and full range of these average changes for each group.~A negative value indicates an improvement in symptoms." (NCT00119015)
Timeframe: Baseline and 2 weeks

Interventionunits on a scale (Median)
Fluticasone Propionate + Montelukast-0.52
Fluticasone Propionate + Placebo-0.29

Change From Baseline in Sneezing Symptom Score Over 2 Week Randomized Treatment Period

"Patients recorded the severity of sneezing twice a day on a scale from 0 to 3 (0 = no symptoms, 1 = mild, 2 = moderate, and 3 = severe). The sneezing symptom score was calculated as the sum of all scores for morning and evening recordings with a range of 0 to 6.~The baseline symptom score used in the analysis was the average of the symptom scores from the last 5 days of fluticasone propionate therapy prior to randomized treatment period.~The change from baseline for each subsequent day of treatment was then calculated for each subject. So that each subject only had one observation, the average of these changes was calculated for each subject, and this summary measure was used in the analysis comparing the two treatment groups. We report the median and full range of these average changes for each group.~A negative value indicates an improvement in symptoms." (NCT00119015)
Timeframe: Baseline and 2 weeks

Interventionunits on a scale (Median)
Fluticasone Propionate + Montelukast-0.22
Fluticasone Propionate + Placebo-0.25

Change From Baseline in Stuffy Nose Symptom Score Over 2 Week Randomized Treatment Period

"Patients recorded the severity of stuffy nose twice a day on a scale from 0 to 3 (0 = no symptoms, 1 = mild, 2 = moderate, and 3 = severe). The stuffy nose symptom score was calculated as the sum of all scores for morning and evening recordings with a range of 0 to 6.~The baseline symptom score used in the analysis was the average of the symptom scores from the last 5 days of fluticasone propionate therapy prior to randomized treatment period.~The change from baseline for each subsequent day of treatment was then calculated for each subject. So that each subject only had one observation, the average of these changes was calculated for each subject, and this summary measure was used in the analysis comparing the two treatment groups. We report the median and full range of these average changes for each group.~A negative value indicates an improvement in symptoms." (NCT00119015)
Timeframe: Baseline and 2 weeks

Interventionunits on a scale (Median)
Fluticasone Propionate + Montelukast-0.41
Fluticasone Propionate + Placebo-0.47

Change From Baseline in Total Nasal Symptom Score (TNSS) Over 2 Week Randomized Treatment Period

"Patients recorded the severity of sneezing, runny nose, stuffy nose, and other symptoms (itchy nose/eyes and post-nasal drip) twice a day on a scale from 0 to 3 (0 = no symptoms, 1 = mild, 2 = moderate, and 3 = severe). The TNSS was calculated as the sum of all scores for morning and evening recordings with a range of 0 to 24.~The baseline TNSS used in the analysis was the average of the symptom scores from the last 5 days of fluticasone propionate therapy prior to randomized treatment period.~The change from baseline for each subsequent day of treatment was then calculated for each subject. So that each subject only had one observation, the average of these changes was calculated for each subject, and this summary measure was used in the analysis comparing the two treatment groups. We report the median and full range of these average changes for each group.~A negative value indicates an improvement in symptoms." (NCT00119015)
Timeframe: Baseline and 2 weeks

Interventionunits on a scale (Median)
Fluticasone Propionate + Montelukast-1.66
Fluticasone Propionate + Placebo-2.21

Reviews

2 reviews available for loratadine and Pruritus

ArticleYear
Oral H1 antihistamines as 'add-on' therapy to topical treatment for eczema.
    The Cochrane database of systematic reviews, 2019, Jan-22, Volume: 1

    Topics: Administration, Oral; Administration, Topical; Adult; Cetirizine; Chemotherapy, Adjuvant; Child; Ecz

2019
Safety and efficacy of desloratadine in subjects with seasonal allergic rhinitis or chronic urticaria: results of four postmarketing surveillance studies.
    Clinical drug investigation, 2010, Volume: 30, Issue:2

    Topics: Activities of Daily Living; Adult; Anti-Allergic Agents; Chronic Disease; Female; Germany; Histamine

2010

Trials

21 trials available for loratadine and Pruritus

ArticleYear
Comparison of the efficacy of levocetirizine 5 mg and desloratadine 5 mg in chronic idiopathic urticaria patients.
    Allergy, 2009, Volume: 64, Issue:4

    Topics: Cetirizine; Chronic Disease; Double-Blind Method; Female; Histamine H1 Antagonists, Non-Sedating; Hu

2009
Efficacy and safety of desloratadine/pseudoephedrine combination vs its components in seasonal allergic rhinitis.
    Journal of investigational allergology & clinical immunology, 2009, Volume: 19, Issue:2

    Topics: Adolescent; Adult; Aged; Bronchodilator Agents; Child; Double-Blind Method; Drug Synergism; Drug The

2009
Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin.
    Jornal brasileiro de nefrologia, 2012, Volume: 34, Issue:2

    Topics: Amines; Cross-Over Studies; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Histam

2012
Rapid effects of olopatadine hydrochloride on the histamine-induced skin responses.
    The Journal of dermatology, 2002, Volume: 29, Issue:11

    Topics: Administration, Oral; Adult; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule;

2002
Fluticasone propionate aqueous nasal spray provided significantly greater improvement in daytime and nighttime nasal symptoms of seasonal allergic rhinitis compared with montelukast.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2003, Volume: 90, Issue:5

    Topics: Acetates; Administration, Intranasal; Administration, Oral; Adult; Androstadienes; Anti-Allergic Age

2003
Fluticasone propionate aqueous nasal spray provided significantly greater improvement in daytime and nighttime nasal symptoms of seasonal allergic rhinitis compared with montelukast.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2003, Volume: 90, Issue:5

    Topics: Acetates; Administration, Intranasal; Administration, Oral; Adult; Androstadienes; Anti-Allergic Age

2003
Fluticasone propionate aqueous nasal spray provided significantly greater improvement in daytime and nighttime nasal symptoms of seasonal allergic rhinitis compared with montelukast.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2003, Volume: 90, Issue:5

    Topics: Acetates; Administration, Intranasal; Administration, Oral; Adult; Androstadienes; Anti-Allergic Age

2003
Fluticasone propionate aqueous nasal spray provided significantly greater improvement in daytime and nighttime nasal symptoms of seasonal allergic rhinitis compared with montelukast.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2003, Volume: 90, Issue:5

    Topics: Acetates; Administration, Intranasal; Administration, Oral; Adult; Androstadienes; Anti-Allergic Age

2003
Comparison of the effects of desloratadine and levocetirizine on histamine-induced wheal, flare and itch in human skin.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2003, Volume: 52, Issue:10

    Topics: Adult; Anti-Allergic Agents; Cetirizine; Cross-Over Studies; Double-Blind Method; Erythema; Histamin

2003
A comparative study on the effects of naltrexone and loratadine on uremic pruritus.
    Dermatology (Basel, Switzerland), 2004, Volume: 208, Issue:4

    Topics: Antipruritics; Drug Administration Schedule; Female; Humans; Loratadine; Male; Middle Aged; Naltrexo

2004
Desloratadine in combination with montelukast in the treatment of chronic urticaria: a randomized, double-blind, placebo-controlled study.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2004, Volume: 34, Issue:9

    Topics: Acetates; Administration, Oral; Adolescent; Adult; Aged; Chronic Disease; Cyclopropanes; Double-Blin

2004
[Clinical effect of escin on patients with cutaneous pruritus caused by blood stasis and wind-dryness].
    Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, 2004, Volume: 2, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Escin; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Lorat

2004
The effect of montelukast (10mg daily) and loratadine (10mg daily) on wheal, flare and itching reactions in skin prick tests.
    Pulmonary pharmacology & therapeutics, 2007, Volume: 20, Issue:1

    Topics: Acetates; Allergens; Antipruritics; Capsules; Codeine; Cross-Over Studies; Cyclopropanes; Double-Bli

2007
Efficacy and safety of desloratadine in adults with chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled, multicenter trial.
    American journal of clinical dermatology, 2007, Volume: 8, Issue:1

    Topics: Adult; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H1

2007
Comparison of inhibition of cutaneous histamine reaction of ebastine fast-dissolving tablet (20 mg) versus desloratadine capsule (5 mg): a randomized, double-blind, double-dummy, placebo-controlled, three-period crossover study in healthy, nonatopic adult
    Clinical therapeutics, 2007, Volume: 29, Issue:5

    Topics: Adolescent; Adult; Butyrophenones; Cross-Over Studies; Double-Blind Method; Female; Histamine; Hista

2007
Therapeutic effect of loratadine on pruritus in patients with atopic dermatitis. A multi-crossover-designed study.
    Allergy, 1994, Volume: 49, Issue:1

    Topics: Adult; Circadian Rhythm; Dermatitis, Atopic; Double-Blind Method; Female; Humans; Loratadine; Male;

1994
Onset of action and efficacy of terfenadine, astemizole, cetirizine, and loratadine for the relief of symptoms of allergic rhinitis.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1997, Volume: 79, Issue:2

    Topics: Adolescent; Adult; Anti-Allergic Agents; Astemizole; Cetirizine; Double-Blind Method; Environmental

1997
Efficacy and safety of mizolastine 10 mg in a placebo-controlled comparison with loratadine in chronic idiopathic urticaria: results of the MILOR Study.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 1999, Volume: 12, Issue:1

    Topics: Adult; Analysis of Variance; Appendicitis; Benzimidazoles; Chronic Disease; Double-Blind Method; Ele

1999
Once-daily desloratadine improves the signs and symptoms of chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled study.
    International journal of dermatology, 2001, Volume: 40, Issue:1

    Topics: Adolescent; Adult; Aged; Cholinergic Antagonists; Chronic Disease; Dizziness; Double-Blind Method; D

2001
Comparison of cetirizine, ebastine and loratadine in the treatment of immediate mosquito-bite allergy.
    Allergy, 2002, Volume: 57, Issue:6

    Topics: Adult; Animals; Butyrophenones; Cetirizine; Conscious Sedation; Cross-Over Studies; Culicidae; Doubl

2002
Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria.
    Arzneimittel-Forschung, 1992, Volume: 42, Issue:9

    Topics: Adolescent; Adult; Aged; Chronic Disease; Double-Blind Method; Humans; Hydroxyzine; Loratadine; Midd

1992
Comparative efficacy of loratadine and terfenadine in the treatment of chronic idiopathic urticaria.
    International journal of dermatology, 1992, Volume: 31, Issue:5

    Topics: Adult; Chronic Disease; Cyproheptadine; Female; Histamine Antagonists; Humans; Loratadine; Male; Pru

1992
Efficacy of an oral antihistamine, loratadine, as compared with a nasal steroid spray, beclomethasone dipropionate, in seasonal allergic rhinitis.
    Clinical otolaryngology and allied sciences, 1991, Volume: 16, Issue:6

    Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Beclomethasone; Cyproheptadine; Doubl

1991
[Treatment of pruritic skin diseases with loratadine. Results of an open multicenter study].
    Fortschritte der Medizin, 1991, Mar-10, Volume: 109, Issue:7

    Topics: Adolescent; Adult; Aged; Cyproheptadine; Drug Evaluation; Female; Histamine Antagonists; Humans; Lor

1991

Other Studies

9 other studies available for loratadine and Pruritus

ArticleYear
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
    Science translational medicine, 2019, 07-10, Volume: 11, Issue:500

    Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S

2019
Analysis of the clinical effect of pregabalin capsule combined with loratadine dispersible tablets in the treatment of uremic skin pruritus.
    Minerva medica, 2023, Volume: 114, Issue:3

    Topics: Humans; Loratadine; Pregabalin; Pruritus; Tablets

2023
A Patient with Jaundice and Pruritus, Not the Usual Suspect?
    Gastroenterology, 2019, Volume: 157, Issue:1

    Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Glucocorticoids; Glutamyl Aminopeptidase; Hepatit

2019
A common but interesting case history.
    Journal of the Royal Naval Medical Service, 2009, Volume: 95, Issue:3

    Topics: Adult; Antipruritics; Exercise; Humans; Loratadine; Male; Military Personnel; Naval Medicine; Prurit

2009
CB1 receptors mediate rimonabant-induced pruritic responses in mice: investigation of locus of action.
    Psychopharmacology, 2011, Volume: 216, Issue:3

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Fem

2011
[Cutaneous reaction after pyrazinamide initiation].
    Medecine et maladies infectieuses, 2011, Volume: 41, Issue:9

    Topics: Adult; Antitubercular Agents; Drug Combinations; Drug Eruptions; Drug Therapy, Combination; Dysgeusi

2011
Cutaneous lepidopterism: dermatitis from contact with moths of Hylesia metabus (Cramer 1775) (Lepidoptera: Saturniidae), the causative agent of caripito itch.
    International journal of dermatology, 2011, Volume: 50, Issue:5

    Topics: Adolescent; Adult; Anesthetics, Local; Animals; Antipruritics; Chlorpheniramine; Dermatitis, Contact

2011
Tolerance induction to rofecoxib in a patient with Bartter's syndrome.
    Allergy, 2004, Volume: 59, Issue:7

    Topics: Adult; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Bartter

2004
Spontaneous scratching behaviour in DS-Nh mice as a possible model for pruritus in atopic dermatitis.
    Immunology, 2006, Volume: 118, Issue:3

    Topics: Animals; Antipruritics; Cells, Cultured; Dermatitis, Atopic; Disease Models, Animal; Histamine; Hist

2006