loratadine has been researched along with Pregnancy in 11 studies
Loratadine: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
loratadine : A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We sought to determine whether the use of loratadine in the first trimester of pregnancy was associated with an increased risk for major malformations." | 9.10 | Fetal safety of loratadine use in the first trimester of pregnancy: a multicenter study. ( Addis, A; Bar-Oz, B; Berkovitch, M; Caprara, D; Coutinho, CJ; Jovanovski, E; Koren, G; Moretti, ME; Schüler-Faccini, L, 2003) |
| "Callers who were counseled by the Israeli Teratogen Information Service in regard to loratadine or OAH exposure during pregnancy were prospectively collected and followed up." | 9.10 | Pregnancy outcome after gestational exposure to loratadine or antihistamines: a prospective controlled cohort study. ( Aharonovich, A; Arnon, J; Diav-Citrin, O; Moerman, L; Ornoy, A; Shechtman, S; Wajnberg, R, 2003) |
| " Desloratadine therapy significantly reduced nasal and ocular symptom severity, itching and wheals, and sleep and activity disruption (p < 0." | 8.86 | Safety and efficacy of desloratadine in subjects with seasonal allergic rhinitis or chronic urticaria: results of four postmarketing surveillance studies. ( Bachert, C; Maurer, M, 2010) |
| "This meta-analysis was designed to assess the strength of the association between loratadine and hypospadias." | 8.84 | Risk of hypospadias in offspring of women using loratadine during pregnancy: a systematic review and meta-analysis. ( Koren, G; Moretti, ME; Nayak, S; Schwarz, EB, 2008) |
| "Desloratadine is a frequently used drug for the treatment of allergic disorders, which often also require treatment during pregnancy." | 7.96 | Desloratadine Use During Pregnancy and Risk of Adverse Fetal Outcomes: A Nationwide Cohort Study. ( Andersen, JT; Andersson, NW; Poulsen, HE, 2020) |
| "We sought to determine whether the use of loratadine in the first trimester of pregnancy was associated with an increased risk for major malformations." | 5.10 | Fetal safety of loratadine use in the first trimester of pregnancy: a multicenter study. ( Addis, A; Bar-Oz, B; Berkovitch, M; Caprara, D; Coutinho, CJ; Jovanovski, E; Koren, G; Moretti, ME; Schüler-Faccini, L, 2003) |
| "Callers who were counseled by the Israeli Teratogen Information Service in regard to loratadine or OAH exposure during pregnancy were prospectively collected and followed up." | 5.10 | Pregnancy outcome after gestational exposure to loratadine or antihistamines: a prospective controlled cohort study. ( Aharonovich, A; Arnon, J; Diav-Citrin, O; Moerman, L; Ornoy, A; Shechtman, S; Wajnberg, R, 2003) |
| " Desloratadine therapy significantly reduced nasal and ocular symptom severity, itching and wheals, and sleep and activity disruption (p < 0." | 4.86 | Safety and efficacy of desloratadine in subjects with seasonal allergic rhinitis or chronic urticaria: results of four postmarketing surveillance studies. ( Bachert, C; Maurer, M, 2010) |
| "This meta-analysis was designed to assess the strength of the association between loratadine and hypospadias." | 4.84 | Risk of hypospadias in offspring of women using loratadine during pregnancy: a systematic review and meta-analysis. ( Koren, G; Moretti, ME; Nayak, S; Schwarz, EB, 2008) |
| "Desloratadine is a frequently used drug for the treatment of allergic disorders, which often also require treatment during pregnancy." | 3.96 | Desloratadine Use During Pregnancy and Risk of Adverse Fetal Outcomes: A Nationwide Cohort Study. ( Andersen, JT; Andersson, NW; Poulsen, HE, 2020) |
| " We focused on maternal race/ethnicity and five maternal risk factors: obesity, use of folic acid-containing multivitamins, opioid analgesics, selective serotonin reuptake inhibitors, and loratadine because of their prevalence of use and some reports of associations with major birth defects." | 3.81 | Maternal exposures in the National Birth Defects Prevention Study: Time trends of selected exposures. ( Arth, A; Canfield, MA; Dawson, AL; Parker, SE; Razzaghi, H; Reefhuis, J, 2015) |
| "Histamine is a key mediator of the allergic immediate reaction." | 2.43 | [Oral second generation antihistamines in allergic rhinitis]. ( Riechelmann, H, 2005) |
| "Desloratadine is a non-sedating, long-acting histamine H(1) receptor antagonist indicated for the symptomatic relief of allergic rhinitis (AR) and chronic idiopathic urticaria in patients aged>12 years." | 1.35 | Examining the tolerability of the non-sedating antihistamine desloratadine: a prescription-event monitoring study in England. ( Layton, D; Shakir, SA; Wilton, L, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Andersson, NW | 1 |
| Poulsen, HE | 1 |
| Andersen, JT | 1 |
| Dawson, AL | 1 |
| Razzaghi, H | 1 |
| Arth, A | 1 |
| Canfield, MA | 1 |
| Parker, SE | 1 |
| Reefhuis, J | 1 |
| Schwarz, EB | 1 |
| Moretti, ME | 2 |
| Nayak, S | 1 |
| Koren, G | 2 |
| Layton, D | 1 |
| Wilton, L | 1 |
| Shakir, SA | 1 |
| Bachert, C | 1 |
| Maurer, M | 1 |
| Caprara, D | 1 |
| Coutinho, CJ | 1 |
| Bar-Oz, B | 1 |
| Berkovitch, M | 1 |
| Addis, A | 1 |
| Jovanovski, E | 1 |
| Schüler-Faccini, L | 1 |
| Diav-Citrin, O | 1 |
| Shechtman, S | 1 |
| Aharonovich, A | 1 |
| Moerman, L | 1 |
| Arnon, J | 1 |
| Wajnberg, R | 1 |
| Ornoy, A | 1 |
| Riechelmann, H | 1 |
| Pedersen, L | 1 |
| Nørgaard, M | 1 |
| Rothman, KJ | 1 |
| Sørensen, HT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Aprepitant vs. Desloratadine in Non-small Cell Lung Cancer Patients With Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Related Pruritus: A Prospective, Randomized Control, Double-blinded, Phase II Clinical Trial[NCT02646020] | Phase 2 | 138 participants (Actual) | Interventional | 2015-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for loratadine and Pregnancy
| Article | Year |
|---|---|
Risk of hypospadias in offspring of women using loratadine during pregnancy: a systematic review and meta-analysis.
Topics: Abnormalities, Drug-Induced; Anti-Allergic Agents; Female; Humans; Hypospadias; Loratadine; Male; Mo | 2008 |
Safety and efficacy of desloratadine in subjects with seasonal allergic rhinitis or chronic urticaria: results of four postmarketing surveillance studies.
Topics: Activities of Daily Living; Adult; Anti-Allergic Agents; Chronic Disease; Female; Germany; Histamine | 2010 |
[Oral second generation antihistamines in allergic rhinitis].
Topics: Administration, Oral; Adult; Anti-Allergic Agents; Cetirizine; Child; Conjunctivitis, Allergic; Cont | 2005 |
2 trials available for loratadine and Pregnancy
| Article | Year |
|---|---|
Fetal safety of loratadine use in the first trimester of pregnancy: a multicenter study.
Topics: Abnormalities, Drug-Induced; Adult; Anti-Allergic Agents; Control Groups; Dose-Response Relationship | 2003 |
Pregnancy outcome after gestational exposure to loratadine or antihistamines: a prospective controlled cohort study.
Topics: Abnormalities, Drug-Induced; Adult; Cohort Studies; Female; Follow-Up Studies; Histamine Antagonists | 2003 |
6 other studies available for loratadine and Pregnancy
| Article | Year |
|---|---|
Desloratadine Use During Pregnancy and Risk of Adverse Fetal Outcomes: A Nationwide Cohort Study.
Topics: Cohort Studies; Female; Humans; Infant, Newborn; Loratadine; Pregnancy; Pregnancy Outcome; Premature | 2020 |
Maternal exposures in the National Birth Defects Prevention Study: Time trends of selected exposures.
Topics: Adult; Analgesics, Opioid; Anti-Allergic Agents; Case-Control Studies; Congenital Abnormalities; Eth | 2015 |
Examining the tolerability of the non-sedating antihistamine desloratadine: a prescription-event monitoring study in England.
Topics: Adult; Cohort Studies; Drug Prescriptions; Drug Utilization; England; Female; Headache; Histamine H1 | 2009 |
Loratadine, desloratadine and pregnancy: don't use, risk of hypospadias.
Topics: Contraindications; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Hypospadias; Loratadine; | 2003 |
Loratadine during pregnancy and hypospadias.
Topics: Abnormalities, Drug-Induced; Anti-Allergic Agents; Case-Control Studies; Denmark; Female; Humans; Hy | 2008 |
New drug bulletins: loratadine (Clarium); rimantadine (Flumadine).
Topics: Adult; Aged; Child; Female; Humans; Loratadine; Male; Pregnancy; Rimantadine | 1994 |