loratadine has been researched along with Muscle Contraction in 5 studies
Loratadine: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
loratadine : A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorpheniramine maleate is a stable, most potent, sedative first generation anti-histamine and is effective in the treatment of allergic disorders." | 1.32 | To evaluate and compare the effects of first generation anti-histamine (chlorpheniramine maleate) and second generation anti-histamine (loratadine) on isolated trachea of rabbit. ( Aamir, K; Ashraf, R; Jalbani, GA; Shaikh, AM; Soomro, FM; Unar, MA, 2004) |
| "Desloratadine was found to be a competitive antagonist (pA2 = 6." | 1.30 | Anticholinergic effects of desloratadine, the major metabolite of loratadine, in rabbit and guinea-pig iris smooth muscle. ( Antón, F; Beleta, J; Cardelús, I; Palacios, JM, 1999) |
| "Loratadine inhibited an increase in dye leakage into the nasal cavity in rats." | 1.29 | Effect of loratadine on immediate and delayed type hypersensitivity reactions. ( Akagi, M; Izushi, K; Kamei, C; Mio, M; Nakamura, S; Tasaka, K; Yoshida, T, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carceller, E | 1 |
| Merlos, M | 1 |
| Giral, M | 1 |
| Balsa, D | 1 |
| Almansa, C | 1 |
| Bartrolí, J | 1 |
| García-Rafanell, J | 1 |
| Forn, J | 1 |
| Lin, Y | 1 |
| Wang, Y | 1 |
| Sima, LF | 1 |
| Wang, DH | 1 |
| Chen, LG | 1 |
| Li, L | 1 |
| Jalbani, GA | 1 |
| Aamir, K | 1 |
| Shaikh, AM | 1 |
| Unar, MA | 1 |
| Ashraf, R | 1 |
| Soomro, FM | 1 |
| Tasaka, K | 1 |
| Kamei, C | 1 |
| Akagi, M | 1 |
| Mio, M | 1 |
| Izushi, K | 1 |
| Yoshida, T | 1 |
| Nakamura, S | 1 |
| Cardelús, I | 1 |
| Antón, F | 1 |
| Beleta, J | 1 |
| Palacios, JM | 1 |
5 other studies available for loratadine and Muscle Contraction
| Article | Year |
|---|---|
[(3-Pyridylalkyl)piperidylidene]benzocycloheptapyridine derivatives as dual antagonists of PAF and histamine.
Topics: Anaphylaxis; Animals; Benzocycloheptenes; Blood Pressure; Guinea Pigs; Histamine; Histamine H1 Antag | 1994 |
Design, synthesis and antihistamine evaluations of several N-hydroxyalkyl desloratadine analogues.
Topics: Animals; Asthma; Chemistry Techniques, Synthetic; Drug Design; Female; Guinea Pigs; Histamine; Hista | 2012 |
To evaluate and compare the effects of first generation anti-histamine (chlorpheniramine maleate) and second generation anti-histamine (loratadine) on isolated trachea of rabbit.
Topics: Animals; Chlorpheniramine; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Loratad | 2004 |
Effect of loratadine on immediate and delayed type hypersensitivity reactions.
Topics: Acetylcholine; Animals; Edema; Granuloma; Guinea Pigs; Histamine; Histamine Release; Hypersensitivit | 1995 |
Anticholinergic effects of desloratadine, the major metabolite of loratadine, in rabbit and guinea-pig iris smooth muscle.
Topics: Animals; Cholinergic Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Female; In Vi | 1999 |