loratadine and Long QT Syndrome
loratadine has been researched along with Long QT Syndrome in 5 studies
Loratadine: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
loratadine : A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Cetirizine is a metabolite of hydroxyzine, another antihistamine." | 2.46 | Cetirizine and loratadine: minimal risk of QT prolongation. ( , 2010) |
Research
Studies (5)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 4 (80.00) | 29.6817 |
2010's | 1 (20.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Cavalli, A | 1 |
Poluzzi, E | 1 |
De Ponti, F | 1 |
Recanatini, M | 1 |
Atar, S | 1 |
Freedberg, NA | 1 |
Antonelli, D | 1 |
Rosenfeld, T | 1 |
Lehman, JM | 1 |
Blaiss, MS | 1 |
Henderson, W | 1 |
Chu, J | 1 |
Hoffman, R | 1 |
Reviews
2 reviews available for loratadine and Long QT Syndrome
Article | Year |
---|---|
Cetirizine and loratadine: minimal risk of QT prolongation.
Topics: Anti-Allergic Agents; Cetirizine; Drug Interactions; Histamine H1 Antagonists, Non-Sedating; Humans; | 2010 |
Selecting the optimal oral antihistamine for patients with allergic rhinitis.
Topics: Administration, Oral; Cardiovascular System; Central Nervous System; Cetirizine; Drug Interactions; | 2006 |
Other Studies
3 other studies available for loratadine and Long QT Syndrome
Article | Year |
---|---|
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go- | 2002 |
Torsades de pointes and QT prolongation due to a combination of loratadine and amiodarone.
Topics: Aged; Amiodarone; Anti-Allergic Agents; Anti-Arrhythmia Agents; Electrocardiography; Female; Humans; | 2003 |
QTc prolongation and drugs.
Topics: Antidepressive Agents, Second-Generation; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cyt | 2001 |