loratadine has been researched along with Epilepsy in 3 studies
Loratadine: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
loratadine : A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We selected adverse drug reaction (ADR) reports on H1-antihistamines in children (0-16 years) up to June 2014 from VigiBase." | 1.46 | Safety profile of H1-antihistamines in pediatrics: an analysis based on data from VigiBase. ( Biagi, C; Calamelli, E; Cipriani, F; Donati, M; Melis, M; Monaco, L; Motola, D; Ricci, G; Vaccheri, A, 2017) |
| "Desloratadine is a frequently used second-generation antihistamine considered to be effective and safe for the treatment of allergic diseases." | 1.39 | Seizures induced by desloratadine, a second-generation antihistamine: clinical observations. ( Cerminara, C; Curatolo, P; El-Malhany, N; Lo Castro, A; Roberto, D, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Motola, D | 1 |
| Donati, M | 1 |
| Biagi, C | 1 |
| Calamelli, E | 1 |
| Cipriani, F | 1 |
| Melis, M | 1 |
| Monaco, L | 1 |
| Vaccheri, A | 1 |
| Ricci, G | 1 |
| Cerminara, C | 1 |
| El-Malhany, N | 1 |
| Roberto, D | 1 |
| Lo Castro, A | 1 |
| Curatolo, P | 1 |
| Fujii, Y | 1 |
| Tanaka, T | 1 |
| Harada, C | 1 |
| Hirai, T | 1 |
| Kamei, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Toxicological Screening by GC-MS Among Children Admitted for a First Afebrile Seizure (CASTox): a Pilot Study[NCT03310697] | 48 participants (Actual) | Interventional | 2017-12-19 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for loratadine and Epilepsy
| Article | Year |
|---|---|
Safety profile of H1-antihistamines in pediatrics: an analysis based on data from VigiBase.
Topics: Adolescent; Adverse Drug Reaction Reporting Systems; Cetirizine; Child; Child Mortality; Child, Pres | 2017 |
Seizures induced by desloratadine, a second-generation antihistamine: clinical observations.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Histamine H1 Antagonists, Non-Sedating; Human | 2013 |
Epileptogenic activity induced by histamine H(1) antagonists in amygdala-kindled rats.
Topics: Amygdala; Animals; Cetirizine; Diphenhydramine; Electroencephalography; Epilepsy; Histamine H1 Antag | 2003 |