loratadine has been researched along with Disease Models, Animal in 18 studies
Loratadine: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
loratadine : A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The work aimed to develop a co-loaded loratadine and sulpiride nasal nanoemulsion for allergic rhinitis management." | 8.02 | A novel nasal co-loaded loratadine and sulpiride nanoemulsion with improved downregulation of TNF-α, TGF-β and IL-1 in rabbit models of ovalbumin-induced allergic rhinitis. ( Badawi, AM; Elrehany, M; Maher, SA; Mansour, HF; Mohamad, SA; Safwat, MA, 2021) |
| "We think that berberine and coenzyme Q10 can usefully be employed as therapy due to their antioxidant and anti-inflammatory effects in an experimentally induced allergic rhinitis model." | 7.88 | The ameliorative effect of berberine and coenzyme Q10 in an ovalbumin-induced allergic rhinitis model. ( Kandemir, FM; Kilic, K; Kucukler, S; Saglam, YS; Sahin, A; Sakat, MS; Yildirim, S, 2018) |
| "Desloratadine is a biologically active metabolite of loratadine which is indicated for the treatment of allergic rhinitis." | 7.83 | The role of endothelin-1 and endothelin receptor antagonists in allergic rhinitis inflammation: ovalbumin-induced rat model. ( Halici, Z; Kose, D; Polat, E; Tatar, A; Yayla, M; Yoruk, O, 2016) |
| "We sought to evaluate the effect of DL on allergic-airway responses in mice after inhalation of the naturally occurring aeroallergen Aspergillus fumigatus (Af ) and to examine the effects of DL on specific immune responses to a defined protein antigen with the use of an ovalbumin (OVA) model of asthma." | 7.72 | Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma. ( Bryce, PJ; Geha, R; Oettgen, HC, 2003) |
| "Desloratadine treatment alleviated AR symptoms, decreased serum level of OVA-specific IgE and IL-17 in AR rats." | 5.56 | Desloratadine Ameliorates Olfactory Disorder and Suppresses AMPA Receptor GluA1 Expression in Allergic Rhinitis Rat. ( Huang, Y; Jiang, X; Jiang, Y; Li, N; Li, S; Li, Z; Zhang, J; Zhang, N; Zhang, X; Zhao, H, 2020) |
| "Desloratadine is a novel, long-acting inhibitor of histamine." | 5.42 | Effects of desloratadine citrate disodium injection on rat models of ovalbumin-induced allergic rhinitis: involvement of T-cell responses modulation. ( Ghosh, A; He, G; Jie, Q; Wu, Y; Yuan, X, 2015) |
| "The work aimed to develop a co-loaded loratadine and sulpiride nasal nanoemulsion for allergic rhinitis management." | 4.02 | A novel nasal co-loaded loratadine and sulpiride nanoemulsion with improved downregulation of TNF-α, TGF-β and IL-1 in rabbit models of ovalbumin-induced allergic rhinitis. ( Badawi, AM; Elrehany, M; Maher, SA; Mansour, HF; Mohamad, SA; Safwat, MA, 2021) |
| "We think that berberine and coenzyme Q10 can usefully be employed as therapy due to their antioxidant and anti-inflammatory effects in an experimentally induced allergic rhinitis model." | 3.88 | The ameliorative effect of berberine and coenzyme Q10 in an ovalbumin-induced allergic rhinitis model. ( Kandemir, FM; Kilic, K; Kucukler, S; Saglam, YS; Sahin, A; Sakat, MS; Yildirim, S, 2018) |
| "Desloratadine is a biologically active metabolite of loratadine which is indicated for the treatment of allergic rhinitis." | 3.83 | The role of endothelin-1 and endothelin receptor antagonists in allergic rhinitis inflammation: ovalbumin-induced rat model. ( Halici, Z; Kose, D; Polat, E; Tatar, A; Yayla, M; Yoruk, O, 2016) |
| "Sneezing and nasal scratching after challenges were significantly ameliorated in the Shu-Bi-Lin-treated group compared with the ovalbumin-sensitized and untreated group, but rhinorrhea volume was not reduced." | 3.73 | Effect of a Chinese herbal formula, Shi-Bi-Lin, on an experimental model of allergic rhinitis. ( Chen, GG; Leung, PC; van Hasselt, CA; Wang, LH; Wong, YO; Woo, JK; Zhao, Y, 2006) |
| "We sought to evaluate the effect of DL on allergic-airway responses in mice after inhalation of the naturally occurring aeroallergen Aspergillus fumigatus (Af ) and to examine the effects of DL on specific immune responses to a defined protein antigen with the use of an ovalbumin (OVA) model of asthma." | 3.72 | Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma. ( Bryce, PJ; Geha, R; Oettgen, HC, 2003) |
| "Desloratadine treatment alleviated AR symptoms, decreased serum level of OVA-specific IgE and IL-17 in AR rats." | 1.56 | Desloratadine Ameliorates Olfactory Disorder and Suppresses AMPA Receptor GluA1 Expression in Allergic Rhinitis Rat. ( Huang, Y; Jiang, X; Jiang, Y; Li, N; Li, S; Li, Z; Zhang, J; Zhang, N; Zhang, X; Zhao, H, 2020) |
| "Desloratadine is a novel, long-acting inhibitor of histamine." | 1.42 | Effects of desloratadine citrate disodium injection on rat models of ovalbumin-induced allergic rhinitis: involvement of T-cell responses modulation. ( Ghosh, A; He, G; Jie, Q; Wu, Y; Yuan, X, 2015) |
| "Itching is one of the major clinical symptoms in atopic dermatitis (AD) and complicates the management of this pathological condition." | 1.33 | Spontaneous scratching behaviour in DS-Nh mice as a possible model for pruritus in atopic dermatitis. ( Arimura, A; Asakawa, M; Deguchi, M; Hikita, I; Hirasawa, T; Horikawa, T; Matsutani, T; Oku, H; Yoshioka, T, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 10 (55.56) | 24.3611 |
| 2020's | 4 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, W | 1 |
| Zhou, J | 1 |
| Zhang, T | 1 |
| Zhu, H | 1 |
| Qian, H | 1 |
| Zhang, H | 1 |
| Huang, W | 1 |
| Gust, R | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Uda, N | 1 |
| Ogata, S | 1 |
| Yamasaki, N | 1 |
| Miura, S | 1 |
| Hosomi, N | 1 |
| Mori, A | 1 |
| Gotoh, M | 1 |
| Miura, K | 1 |
| Kaminuma, O | 1 |
| Li, S | 1 |
| Zhang, X | 1 |
| Li, Z | 1 |
| Jiang, X | 1 |
| Zhang, N | 1 |
| Zhang, J | 1 |
| Huang, Y | 1 |
| Zhao, H | 1 |
| Jiang, Y | 1 |
| Li, N | 1 |
| Mohamad, SA | 1 |
| Safwat, MA | 1 |
| Elrehany, M | 1 |
| Maher, SA | 1 |
| Badawi, AM | 1 |
| Mansour, HF | 1 |
| Sakat, MS | 1 |
| Kilic, K | 1 |
| Kandemir, FM | 1 |
| Yildirim, S | 1 |
| Sahin, A | 1 |
| Kucukler, S | 1 |
| Saglam, YS | 1 |
| Wex, E | 1 |
| Thaler, E | 1 |
| Blum, S | 1 |
| Lamb, D | 1 |
| Yuan, X | 1 |
| Ghosh, A | 1 |
| Jie, Q | 2 |
| He, G | 2 |
| Wu, Y | 2 |
| Tatar, A | 2 |
| Parlak, SN | 1 |
| Yayla, M | 2 |
| Ugan, RA | 1 |
| Polat, E | 2 |
| Halici, Z | 2 |
| Chen, M | 1 |
| Xu, S | 1 |
| Zhou, P | 1 |
| Kose, D | 1 |
| Yoruk, O | 1 |
| Wang, XR | 1 |
| Zhou, C | 1 |
| Zhong, ZD | 1 |
| Duan, Q | 1 |
| Du, AY | 1 |
| Jing, G | 1 |
| Schlosburg, JE | 1 |
| O'Neal, ST | 1 |
| Conrad, DH | 1 |
| Lichtman, AH | 1 |
| Bryce, PJ | 1 |
| Geha, R | 1 |
| Oettgen, HC | 1 |
| Zhao, Y | 1 |
| van Hasselt, CA | 1 |
| Woo, JK | 1 |
| Chen, GG | 1 |
| Wong, YO | 1 |
| Wang, LH | 1 |
| Leung, PC | 1 |
| Yoshioka, T | 1 |
| Hikita, I | 1 |
| Asakawa, M | 1 |
| Hirasawa, T | 1 |
| Deguchi, M | 1 |
| Matsutani, T | 1 |
| Oku, H | 1 |
| Horikawa, T | 1 |
| Arimura, A | 1 |
| Chimona, TS | 1 |
| Panayiotides, JG | 1 |
| Papadakis, CE | 1 |
| Helidonis, ES | 1 |
| Velegrakis, GA | 1 |
18 other studies available for loratadine and Disease Models, Animal
| Article | Year |
|---|---|
Design and synthesis of thiourea derivatives containing a benzo[5,6]cyclohepta[1,2-b]pyridine moiety as potential antitumor and anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Biological Assay; Breast Neoplasms; Cell L | 2012 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Re-evaluation of over-the-counter histamine H1-receptor antagonists based on their effects on murine models of allergen-induced nasal hyperresponsiveness.
Topics: Allergens; Animals; Disease Models, Animal; Histamine; Histamine H1 Antagonists; Loratadine; Mice | 2022 |
Desloratadine Ameliorates Olfactory Disorder and Suppresses AMPA Receptor GluA1 Expression in Allergic Rhinitis Rat.
Topics: Animals; Disease Models, Animal; Histamine H1 Antagonists, Non-Sedating; Immunoglobulin E; Interleuk | 2020 |
A novel nasal co-loaded loratadine and sulpiride nanoemulsion with improved downregulation of TNF-α, TGF-β and IL-1 in rabbit models of ovalbumin-induced allergic rhinitis.
Topics: Administration, Intranasal; Animals; Calorimetry, Differential Scanning; Disease Models, Animal; Dop | 2021 |
The ameliorative effect of berberine and coenzyme Q10 in an ovalbumin-induced allergic rhinitis model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Berberine; Disease Models, Animal; Histamine H1 Ant | 2018 |
A novel model of IgE-mediated passive pulmonary anaphylaxis in rats.
Topics: Aminopyridines; Anaphylaxis; Animals; Anti-Asthmatic Agents; Bronchoalveolar Lavage; Bronchoconstric | 2014 |
Effects of desloratadine citrate disodium injection on rat models of ovalbumin-induced allergic rhinitis: involvement of T-cell responses modulation.
Topics: Allergens; Animals; Cell Adhesion Molecules; Citrates; Cytokines; Disease Models, Animal; Gene Expre | 2015 |
Effects of allergic rhinitis and desloratadine on the submandibular gland in a rat allergy model.
Topics: Animals; Disease Models, Animal; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; | 2015 |
Desloratadine citrate disodium injection, a potent histamine H(1) receptor antagonist, inhibits chemokine production in ovalbumin-induced allergic rhinitis guinea pig model and histamine-induced human nasal epithelial cells via inhibiting the ERK1/2 and N
Topics: Animals; Anti-Allergic Agents; Cells, Cultured; Chemokine CCL2; Chemokine CCL5; Chemokines; Disease | 2015 |
The role of endothelin-1 and endothelin receptor antagonists in allergic rhinitis inflammation: ovalbumin-induced rat model.
Topics: Animals; Bosentan; Disease Models, Animal; Down-Regulation; Endothelin Receptor Antagonists; Endothe | 2016 |
[Effect of Modified Danggui Yinzi on Delayed Allergy in Model Mice with Qi-Blood Deficiency Syndrome].
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Edema; Hypersensitivity, Delayed; Immunoglob | 2016 |
CB1 receptors mediate rimonabant-induced pruritic responses in mice: investigation of locus of action.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Fem | 2011 |
Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Cytokines; Disease Models, Animal; Dose-Respo | 2003 |
Effect of a Chinese herbal formula, Shi-Bi-Lin, on an experimental model of allergic rhinitis.
Topics: Animals; Anti-Allergic Agents; Disease Models, Animal; Drugs, Chinese Herbal; Eosinophils; Guinea Pi | 2006 |
Spontaneous scratching behaviour in DS-Nh mice as a possible model for pruritus in atopic dermatitis.
Topics: Animals; Antipruritics; Cells, Cultured; Dermatitis, Atopic; Disease Models, Animal; Histamine; Hist | 2006 |
Antihistamine effects on experimental middle ear inflammatory model.
Topics: Animals; Cetirizine; Disease Models, Animal; Ear, Middle; Female; Histamine H1 Antagonists, Non-Seda | 2008 |