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loratadine and Arrhythmia

loratadine has been researched along with Arrhythmia in 6 studies

Loratadine: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
loratadine : A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.

Research Excerpts

ExcerptRelevanceReference
"Although the new second-generation nonsedative antihistamines terfenadine and astemizole were launched as highly selective and specific H(1)-receptor antagonists, they were later found to cause prolongation of the QT-interval and severe cardiac arrhythmias."4.81Cardiotoxicity of new antihistamines and cisapride. ( Paakkari, I, 2002)
" In vitro assessment of the proarrhythmic potential of drugs is limited to one compound and thus neglects the potential of drug-drug interactions, including those involving active metabolites."1.48Drug interaction at hERG channel: In vitro assessment of the electrophysiological consequences of drug combinations and comparison against theoretical models. ( Kulig, M; Lisowski, B; Polak, S; Wiśniowska, B, 2018)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (33.33)18.2507
2000's3 (50.00)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Janssens, F1
Leenaerts, J1
Diels, G1
De Boeck, B1
Megens, A1
Langlois, X1
van Rossem, K1
Beetens, J1
Borgers, M1
Jia, L1
Sun, H1
Wiśniowska, B1
Lisowski, B1
Kulig, M1
Polak, S1
Clark, S1
de Abajo, FJ1
Rodríguez, LA1
Paakkari, I1

Reviews

1 review available for loratadine and Arrhythmia

ArticleYear
Cardiotoxicity of new antihistamines and cisapride.
    Toxicology letters, 2002, Feb-28, Volume: 127, Issue:1-3

    Topics: Arrhythmias, Cardiac; Astemizole; Benzimidazoles; Butyrophenones; Cetirizine; Cisapride; Heart Disea

2002

Other Studies

5 other studies available for loratadine and Arrhythmia

ArticleYear
Norpiperidine imidazoazepines as a new class of potent, selective, and nonsedative H1 antihistamines.
    Journal of medicinal chemistry, 2005, Mar-24, Volume: 48, Issue:6

    Topics: Anaphylaxis; Animals; Arrhythmias, Cardiac; Benzazepines; Blood-Brain Barrier; CHO Cells; Cricetinae

2005
Support vector machines classification of hERG liabilities based on atom types.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant

2008
Drug interaction at hERG channel: In vitro assessment of the electrophysiological consequences of drug combinations and comparison against theoretical models.
    Journal of applied toxicology : JAT, 2018, Volume: 38, Issue:4

    Topics: Arrhythmias, Cardiac; Drug Combinations; Drug Interactions; Electrophysiology; ERG1 Potassium Channe

2018
Dangers of non-sedating antihistamines.
    Lancet (London, England), 1997, May-03, Volume: 349, Issue:9061

    Topics: Arrhythmias, Cardiac; Astemizole; Cetirizine; Heart Diseases; Histamine H1 Antagonists; Humans; Legi

1997
Risk of ventricular arrhythmias associated with nonsedating antihistamine drugs.
    British journal of clinical pharmacology, 1999, Volume: 47, Issue:3

    Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Astemizole; Case-Control Studies; Cetirizine; Child;

1999