loratadine has been researched along with Arrhythmia in 6 studies
Loratadine: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
loratadine : A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although the new second-generation nonsedative antihistamines terfenadine and astemizole were launched as highly selective and specific H(1)-receptor antagonists, they were later found to cause prolongation of the QT-interval and severe cardiac arrhythmias." | 4.81 | Cardiotoxicity of new antihistamines and cisapride. ( Paakkari, I, 2002) |
| " In vitro assessment of the proarrhythmic potential of drugs is limited to one compound and thus neglects the potential of drug-drug interactions, including those involving active metabolites." | 1.48 | Drug interaction at hERG channel: In vitro assessment of the electrophysiological consequences of drug combinations and comparison against theoretical models. ( Kulig, M; Lisowski, B; Polak, S; Wiśniowska, B, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Janssens, F | 1 |
| Leenaerts, J | 1 |
| Diels, G | 1 |
| De Boeck, B | 1 |
| Megens, A | 1 |
| Langlois, X | 1 |
| van Rossem, K | 1 |
| Beetens, J | 1 |
| Borgers, M | 1 |
| Jia, L | 1 |
| Sun, H | 1 |
| Wiśniowska, B | 1 |
| Lisowski, B | 1 |
| Kulig, M | 1 |
| Polak, S | 1 |
| Clark, S | 1 |
| de Abajo, FJ | 1 |
| Rodríguez, LA | 1 |
| Paakkari, I | 1 |
1 review available for loratadine and Arrhythmia
| Article | Year |
|---|---|
Cardiotoxicity of new antihistamines and cisapride.
Topics: Arrhythmias, Cardiac; Astemizole; Benzimidazoles; Butyrophenones; Cetirizine; Cisapride; Heart Disea | 2002 |
5 other studies available for loratadine and Arrhythmia
| Article | Year |
|---|---|
Norpiperidine imidazoazepines as a new class of potent, selective, and nonsedative H1 antihistamines.
Topics: Anaphylaxis; Animals; Arrhythmias, Cardiac; Benzazepines; Blood-Brain Barrier; CHO Cells; Cricetinae | 2005 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant | 2008 |
Drug interaction at hERG channel: In vitro assessment of the electrophysiological consequences of drug combinations and comparison against theoretical models.
Topics: Arrhythmias, Cardiac; Drug Combinations; Drug Interactions; Electrophysiology; ERG1 Potassium Channe | 2018 |
Dangers of non-sedating antihistamines.
Topics: Arrhythmias, Cardiac; Astemizole; Cetirizine; Heart Diseases; Histamine H1 Antagonists; Humans; Legi | 1997 |
Risk of ventricular arrhythmias associated with nonsedating antihistamine drugs.
Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Astemizole; Case-Control Studies; Cetirizine; Child; | 1999 |