loratadine has been researched along with Allergic Reaction in 41 studies
Loratadine: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
loratadine : A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study is to compare the efficacy and safety of a once-daily loratadine-pseudoephedrine sustained release tablet with that of a twice-daily loratadine-pseudoephedrine in the treatment of patients with allergic rhinitis." | 9.12 | A randomized, double-blind, parallel-group study to compare the efficacy and safety of a once-daily loratadine-pseudoephedrine combination with that of a twice-daily loratadine-pseudoephedrine combination in the treatment of allergic rhinitis. ( Chang, KP; Chen, YA; Hao, SP; Lin, YS, 2007) |
| "The objective of the study is to assess the efficacy of the nonsedating antihistamine, desloratadine, in the treatment of allergic rhinitis (AR)." | 8.84 | Efficacy of desloratadine in the treatment of allergic rhinitis: a meta-analysis of randomized, double-blind, controlled trials. ( Canonica, GW; Compalati, E; Penagos, M; Tarantini, F, 2007) |
| "The aim of this study is to compare the efficacy and safety of a once-daily loratadine-pseudoephedrine sustained release tablet with that of a twice-daily loratadine-pseudoephedrine in the treatment of patients with allergic rhinitis." | 5.12 | A randomized, double-blind, parallel-group study to compare the efficacy and safety of a once-daily loratadine-pseudoephedrine combination with that of a twice-daily loratadine-pseudoephedrine combination in the treatment of allergic rhinitis. ( Chang, KP; Chen, YA; Hao, SP; Lin, YS, 2007) |
| "The objective of the study is to assess the efficacy of the nonsedating antihistamine, desloratadine, in the treatment of allergic rhinitis (AR)." | 4.84 | Efficacy of desloratadine in the treatment of allergic rhinitis: a meta-analysis of randomized, double-blind, controlled trials. ( Canonica, GW; Compalati, E; Penagos, M; Tarantini, F, 2007) |
| " and intracerebroventricular pentobarbital-induced sedation and alcohol-induced ataxia models." | 3.76 | Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel antihistamine SUN-1334H. ( Bagad, AS; Bahekar, PC; Chidrewar, GU; Mandhane, SN; Mehetre, SV; Pawar, CA; Rajamannar, T; Rao, CT; Shah, JH, 2010) |
| "Histamine and cysteinyl leukotrienes are pivotal mast cell mediators which contribute considerably and likely complementary to the symptoms of allergic rhinitis." | 3.76 | Concomitant activity of histamine and cysteinyl leukotrienes on porcine nasal mucosal vessels and nasal inflammation in the rat. ( Hunter, JC; Jia, Y; Jimenez, J; Lieber, G; McLeod, RL, 2010) |
| " The present studies compared loratadine and terfenadine, another non-sedating antihistamine, for their ability to inhibit the bronchial response to histamine and other autacoids which have been implicated as contributing to the symptoms of an allergic reaction." | 3.67 | Antiallergic activity of loratadine, a non-sedating antihistamine. ( Chapman, RW; Gulbenkian, A; Kreutner, W; Siegel, MI, 1987) |
| "Loratadine is a long-acting antihistamine with selective peripheral histamine H(1)-receptor antagonistic activity and fewer sedative effects compared with conventional antihistamines, and is widely used in Mexico." | 2.72 | Bioavailability of two oral formulations of loratadine 20 mg with concomitant ketoconazole: an open-label, randomized, two-period crossover comparison in healthy Mexican adult volunteers. ( de Lago, A; Gómez Silva, M; Gonzàlez-de la Parra, M; Lujàn Rangel, R; Namur, S; Pineyro-Garza, E; Piñeyro-López, A; Reyes-Araiza, R; Torres-Alanís, O; Trejo, D; Wacksman, N, 2006) |
| "Treatment with loratadine resulted in a significant inhibition of the histamine-induced changes in both nasal and sinus cavities." | 2.69 | Comparison of the response to histamine challenge of the nose and the maxillary sinus: effect of loratadine. ( Baroody, FM; Blair, C; deTineo, M; Gungor, A; Haney, L; Naclerio, RM, 1999) |
| "Terfenadine was more effective than both loratadine (P less than ." | 2.67 | Suppression of epicutaneous reactivity by terfenadine and loratadine. ( Small, P, 1992) |
| "Desloratadine does not cause sedation or prolong the corrected QT (QTc) interval, can be administered without regard to concurrent intake of food and grapefruit juice, and appears to have negligible potential for drug interactions mediated by several metabolic systems." | 2.42 | Desloratadine: an update of its efficacy in the management of allergic disorders. ( Goa, KL; Keam, SJ; Murdoch, D, 2003) |
| "Loratadine is a long-acting antihistamine agent, exhibiting partial selectivity for peripheral histamine H1-receptors." | 2.39 | Loratadine. A reappraisal of its pharmacological properties and therapeutic use in allergic disorders. ( Fitton, A; Haria, M; Peters, DH, 1994) |
| "Loratadine is an addition to the class of nonsedating antihistamines which includes terfenadine, astemizole, and acrivastine." | 2.38 | Loratadine: a nonsedating antihistamine with once-daily dosing. ( Barenholtz, HA; McLeod, DC, 1989) |
| "Loratadine is a selective H1 receptor inhibitor that has been widely used in the clinical treatment of allergic diseases." | 1.62 | Preparation of loratadine nanocrystal tablets to improve the solubility and dissolution for enhanced oral bioavailability. ( Aisha, M; Huang, F; Li, J; Sun, M; Wang, H; Wu, J; Zhou, Y, 2021) |
| "Desloratadine is a frequently used second-generation antihistamine considered to be effective and safe for the treatment of allergic diseases." | 1.39 | Seizures induced by desloratadine, a second-generation antihistamine: clinical observations. ( Cerminara, C; Curatolo, P; El-Malhany, N; Lo Castro, A; Roberto, D, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (4.88) | 18.7374 |
| 1990's | 8 (19.51) | 18.2507 |
| 2000's | 22 (53.66) | 29.6817 |
| 2010's | 6 (14.63) | 24.3611 |
| 2020's | 3 (7.32) | 2.80 |
| Authors | Studies |
|---|---|
| Iwasaki, N | 1 |
| Ohashi, T | 1 |
| Musoh, K | 1 |
| Nishino, H | 1 |
| Kado, N | 1 |
| Yasuda, S | 1 |
| Kato, H | 1 |
| Ito, Y | 1 |
| AlMasoud, N | 1 |
| Bakheit, AH | 1 |
| Alshammari, MFM | 1 |
| Abdel-Aziz, HA | 1 |
| AlRabiah, H | 1 |
| Plekhova, NG | 1 |
| Eliseeva, EV | 1 |
| Dubnyak, IN | 1 |
| Li, J | 1 |
| Zhou, Y | 1 |
| Aisha, M | 1 |
| Wu, J | 1 |
| Wang, H | 1 |
| Huang, F | 1 |
| Sun, M | 1 |
| Cerminara, C | 1 |
| El-Malhany, N | 1 |
| Roberto, D | 1 |
| Lo Castro, A | 1 |
| Curatolo, P | 1 |
| Kamenica, E | 1 |
| Naclerio, R | 1 |
| Malani, A | 1 |
| Sturm, GJ | 2 |
| Kranzelbinder, B | 2 |
| Sturm, EM | 2 |
| Heinemann, A | 2 |
| Groselj-Strele, A | 2 |
| Aberer, W | 2 |
| Mandhane, SN | 1 |
| Shah, JH | 1 |
| Bahekar, PC | 1 |
| Mehetre, SV | 1 |
| Pawar, CA | 1 |
| Bagad, AS | 1 |
| Chidrewar, GU | 1 |
| Rao, CT | 1 |
| Rajamannar, T | 1 |
| Lieber, G | 1 |
| Jimenez, J | 1 |
| Hunter, JC | 1 |
| McLeod, RL | 1 |
| Jia, Y | 1 |
| Schlosburg, JE | 1 |
| O'Neal, ST | 1 |
| Conrad, DH | 1 |
| Lichtman, AH | 1 |
| Underwood, A | 1 |
| Scheinfeld, N | 1 |
| Murdoch, D | 1 |
| Goa, KL | 1 |
| Keam, SJ | 1 |
| Grzelewska-Rzymowska, I | 1 |
| Ortolon, K | 1 |
| Deruaz, C | 1 |
| Leimgruber, A | 1 |
| Berney, M | 1 |
| Pradervand, E | 1 |
| Spertini, F | 1 |
| Fumagalli, F | 1 |
| Baiardini, I | 1 |
| Pasquali, M | 1 |
| Compalati, E | 2 |
| Guerra, L | 1 |
| Massacane, P | 1 |
| Canonica, GW | 2 |
| Blümchen, K | 1 |
| Gerhold, K | 1 |
| Thorade, I | 1 |
| Seib, C | 1 |
| Wahn, U | 1 |
| Hamelmann, E | 1 |
| Khatibi E, A | 1 |
| Samsioe, G | 1 |
| Li, C | 1 |
| Lidfeldbt, J | 1 |
| Agardh, CD | 1 |
| Nerbrand, C | 1 |
| Piñeyro-López, A | 1 |
| Pineyro-Garza, E | 1 |
| Torres-Alanís, O | 1 |
| Reyes-Araiza, R | 1 |
| Gómez Silva, M | 1 |
| Wacksman, N | 1 |
| Lujàn Rangel, R | 1 |
| de Lago, A | 1 |
| Trejo, D | 1 |
| Gonzàlez-de la Parra, M | 1 |
| Namur, S | 1 |
| Camelo-Nunes, IC | 1 |
| Tarantini, F | 1 |
| Penagos, M | 1 |
| Chen, YA | 1 |
| Chang, KP | 1 |
| Lin, YS | 1 |
| Hao, SP | 1 |
| Kiratli, H | 1 |
| Onder, S | 1 |
| Yildiz, S | 1 |
| Ozşeker, H | 1 |
| Barbaud, A | 1 |
| Bursztejn, AC | 1 |
| Schmutz, JL | 1 |
| Trechot, P | 1 |
| Haria, M | 1 |
| Fitton, A | 1 |
| Peters, DH | 1 |
| Miadonna, A | 1 |
| Milazzo, N | 1 |
| Lorini, M | 1 |
| Marchesi, E | 1 |
| Tedeschi, A | 1 |
| Goriachkina, LA | 1 |
| Peredkova, EV | 1 |
| Baroody, FM | 1 |
| Gungor, A | 1 |
| deTineo, M | 1 |
| Haney, L | 1 |
| Blair, C | 1 |
| Naclerio, RM | 1 |
| Abdelaziz, MM | 1 |
| Khair, OA | 1 |
| Devalia, JL | 1 |
| de Longueville, M | 1 |
| Bonini, S | 1 |
| Fridliand, DG | 1 |
| Gushchin, IS | 1 |
| Poroshina, IuA | 1 |
| Shul'zhenko, AE | 1 |
| Small, P | 1 |
| Ryhal, BT | 1 |
| Fletcher, MP | 1 |
| Kreutner, W | 1 |
| Chapman, RW | 1 |
| Gulbenkian, A | 1 |
| Siegel, MI | 1 |
| Barenholtz, HA | 1 |
| McLeod, DC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Toxicological Screening by GC-MS Among Children Admitted for a First Afebrile Seizure (CASTox): a Pilot Study[NCT03310697] | 48 participants (Actual) | Interventional | 2017-12-19 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for loratadine and Allergic Reaction
| Article | Year |
|---|---|
Loratadine.
Topics: Humans; Hypersensitivity; Loratadine; Mass Spectrometry; Solubility; X-Ray Diffraction | 2022 |
The new antihistamines--desloratadine and levocetirizine: a review.
Topics: Acetates; Animals; Area Under Curve; Cetirizine; Half-Life; Histamine H1 Antagonists, Non-Sedating; | 2002 |
Desloratadine: an update of its efficacy in the management of allergic disorders.
Topics: Animals; Clinical Trials as Topic; Drug Interactions; Histamine H1 Antagonists, Non-Sedating; Humans | 2003 |
[Clinical aspects of anti-inflammatory action of antihistamines].
Topics: Cetirizine; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivi | 2003 |
Antihistamines: do they work? Further well-controlled trials involving larger samples are needed.
Topics: Anti-Allergic Agents; Anti-Inflammatory Agents; Cetirizine; Histamine H1 Antagonists; Histamine H1 A | 2004 |
New antihistamines: a critical view.
Topics: Anti-Allergic Agents; Blood-Brain Barrier; Central Nervous System Diseases; Cetirizine; Child; Cypro | 2006 |
Efficacy of desloratadine in the treatment of allergic rhinitis: a meta-analysis of randomized, double-blind, controlled trials.
Topics: Double-Blind Method; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivity; Loratadine; N | 2007 |
Loratadine. A reappraisal of its pharmacological properties and therapeutic use in allergic disorders.
Topics: Animals; Drug Interactions; Humans; Hypersensitivity; Loratadine; Psychomotor Performance | 1994 |
What are the candidate groups for pharmacotherapeutic intervention to prevent asthma?
Topics: Anti-Allergic Agents; Asthma; Cetirizine; Child; Clinical Trials as Topic; Cromolyn Sodium; Dermatit | 2000 |
Desloratadine: a new approach in the treatment of allergy as a systematic disease--pharmacology and clinical overview. Introduction.
Topics: Cholinergic Antagonists; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Histamine | 2001 |
The second-generation antihistamines. What makes them different?
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Blood-Brain Barrier; Brain; Cetirizine; Cyprohepta | 1991 |
Loratadine: a nonsedating antihistamine with once-daily dosing.
Topics: Cyproheptadine; Humans; Hypersensitivity; Loratadine | 1989 |
7 trials available for loratadine and Allergic Reaction
| Article | Year |
|---|---|
Advertisements impact the physiological efficacy of a branded drug.
Topics: Adult; Advertising; Cetirizine; Female; Follow-Up Studies; Histamine H1 Antagonists, Non-Sedating; H | 2013 |
Levocetirizine better protects than desloratadine in a nasal provocation with allergen.
Topics: Adult; Albumins; Allergens; Biomarkers; Cetirizine; Cross-Over Studies; Differential Threshold; Doub | 2004 |
Bioavailability of two oral formulations of loratadine 20 mg with concomitant ketoconazole: an open-label, randomized, two-period crossover comparison in healthy Mexican adult volunteers.
Topics: Administration, Oral; Adolescent; Adult; Antifungal Agents; Biological Availability; Cross-Over Stud | 2006 |
A randomized, double-blind, parallel-group study to compare the efficacy and safety of a once-daily loratadine-pseudoephedrine combination with that of a twice-daily loratadine-pseudoephedrine combination in the treatment of allergic rhinitis.
Topics: Adult; Anti-Allergic Agents; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combin | 2007 |
[The clinical efficacy of Claritin in treating allergic diseases].
Topics: Acute Disease; Adolescent; Adult; Anti-Allergic Agents; Child; Chronic Disease; Histamine H1 Antagon | 1997 |
Comparison of the response to histamine challenge of the nose and the maxillary sinus: effect of loratadine.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; | 1999 |
Suppression of epicutaneous reactivity by terfenadine and loratadine.
Topics: Cyproheptadine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Hypersensitivity; Lor | 1992 |
22 other studies available for loratadine and Allergic Reaction
| Article | Year |
|---|---|
Amphoteric drugs. 3. Synthesis and antiallergic activity of 3-[(5,11-dihydro[1]benzoxepino[4,3-b]pyridin-11- ylidene)piperidino]propionic acid derivatives and related compounds.
Topics: Animals; Capillary Permeability; Central Nervous System; Guinea Pigs; Histamine Antagonists; Hyperse | 1995 |
Antihistamines Modulate Functional Activity of Macrophages.
Topics: Animals; Cells, Cultured; Histamine Antagonists; Humans; Hypersensitivity; Loratadine; Macrophages, | 2021 |
Preparation of loratadine nanocrystal tablets to improve the solubility and dissolution for enhanced oral bioavailability.
Topics: Biological Availability; Drug Compounding; Excipients; Freeze Drying; Histamine H1 Antagonists; Huma | 2021 |
Seizures induced by desloratadine, a second-generation antihistamine: clinical observations.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Histamine H1 Antagonists, Non-Sedating; Human | 2013 |
The basophil activation test in the diagnosis of allergy: technical issues and critical factors.
Topics: Animals; Antibodies, Anti-Idiotypic; Antigens, CD; Basophils; Bee Venoms; Dimethindene; Histamine H1 | 2009 |
Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel antihistamine SUN-1334H.
Topics: Acetates; Alcohols; Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ataxia; Cetirizin | 2010 |
Best drugs for what ails you: the brands to buy--and those to skip.
Topics: Acetaminophen; Anesthetics, Local; Cetirizine; Chlorpheniramine; Common Cold; Cough; Dextromethorpha | 2009 |
Concomitant activity of histamine and cysteinyl leukotrienes on porcine nasal mucosal vessels and nasal inflammation in the rat.
Topics: Acetates; Animals; Cyclopropanes; Cysteine; Dose-Response Relationship, Drug; Drug Synergism; Drug T | 2010 |
CD203c-based basophil activation test in allergy diagnosis: characteristics and differences to CD63 upregulation.
Topics: Adult; Anti-Allergic Agents; Antigens, CD; Arthropod Venoms; Basophil Degranulation Test; Basophils; | 2010 |
CB1 receptors mediate rimonabant-induced pruritic responses in mice: investigation of locus of action.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Fem | 2011 |
Allergy warning.
Topics: Drug Approval; Humans; Hypersensitivity; Insurance, Pharmaceutical Services; Loratadine; Nonprescrip | 2002 |
Patient, medicate thyself.
Topics: Humans; Hypersensitivity; Loratadine; Nonprescription Drugs; Self Medication | 2003 |
Oral administration of desloratadine prior to sensitization prevents allergen-induced airway inflammation and hyper-reactivity in mice.
Topics: Administration, Oral; Allergens; Animals; Bronchial Hyperreactivity; Cells, Cultured; Female; Histam | 2004 |
Does hormone therapy increase allergic reactions and upper gastrointestinal problems? Results from a population-based study of Swedish woman. The women's health in the Lund area (WHILA) study.
Topics: Aged; Anti-Allergic Agents; Anti-Ulcer Agents; Climacteric; Cohort Studies; Female; Gastrointestinal | 2004 |
Eosinophilic angiocentric fibrosis of the orbit.
Topics: Adult; Eosinophilic Granuloma; Female; Fibrosis; Histamine H1 Antagonists, Non-Sedating; Humans; Hyp | 2008 |
Patch tests with desloratadine at 10% induce false-positive results: test at 1%.
Topics: False Positive Reactions; Histamine H1 Antagonists, Non-Sedating; Humans; Hypersensitivity; Loratadi | 2008 |
Antiallergic activity of loratadine: inhibition of leukotriene C4 release from human leucocytes.
Topics: Basophils; Calcium; Extracellular Space; Histamine Release; Humans; Hypersensitivity; Immunoglobulin | 1995 |
[Inflammatory response in the allergic patient. Lemonade taste improves compliance].
Topics: Adult; Anti-Allergic Agents; Child; Humans; Hypersensitivity; Loratadine; Patient Compliance; System | 1999 |
The potential of active metabolites of antihistamines in the management of allergic disease.
Topics: Anti-Inflammatory Agents; Butyrophenones; Cells, Cultured; Cetirizine; Chymases; Eosinophils; Granul | 2000 |
Newer antihistamines.
Topics: Administration, Oral; Anti-Allergic Agents; Cetirizine; Chlorpheniramine; Conscious Sedation; Diphen | 2001 |
[Comparative antihistamine and anti-allergic effects of various antihistamine preparations].
Topics: Adult; Anti-Allergic Agents; Butyrophenones; Cetirizine; Clemastine; Female; Histamine H1 Antagonist | 2002 |
Antiallergic activity of loratadine, a non-sedating antihistamine.
Topics: Animals; Benzhydryl Compounds; Bronchial Spasm; Calcium; Cyproheptadine; Guinea Pigs; Histamine Anta | 1987 |