Page last updated: 2024-08-26

lopinavir and HIV Coinfection

lopinavir has been researched along with HIV Coinfection in 1205 studies

Research

Studies (1,205)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's12 (1.00)18.2507
2000's534 (44.32)29.6817
2010's572 (47.47)24.3611
2020's87 (7.22)2.80

Authors

AuthorsStudies
Dekhtyar, T; Kempf, DJ; Lu, L; Mo, H; Molla, A; Parkin, N; Stewart, KD1
Amano, M; Boross, PI; Das, D; Ghosh, AK; Koh, Y; Leschenko, S; Li, J; Mitsuya, H; Wang, YF; Weber, IT1
Babacan, E; Kaykhin, P; Lötsch, J; Staszewski, S; Stephan, C; Stürmer, M; von Hentig, N1
Aldrovandi, G; Alvero, C; Borkowsky, W; Capparelli, EV; Chadwick, EG; Fenton, T; Havens, PL; Heckman, B; Pelton, SI; Robbins, BL; Rodman, J; Serchuck, L; Smith, ME; Worrell, C; Yogev, R1
Achalapong, J; Chotivanich, N; Cressey, TR; Jourdain, G; Maupin, R; Mirochnick, M; Prommas, S; Puthanakit, T; Roongpisuthipong, A; Shapiro, DE; Smith, E; Van Dyke, R; Yuthavisuthi, P1
Ewart, G; Khoury, G; Luscombe, C; Miller, M; Wilkinson, J1
Gibbs, CS; Margot, NA; Miller, MD1
Lisovsky, I; Martinez-Cajas, JL; Moisi, D; Oliveira, M; Schader, SM; Wainberg, MA1
Brunzelle, JS; Dewdney, TG; Kovari, IA; Kovari, LC; Liu, Z; Reiter, SJ; Sharma, SK; Wang, Y; Woster, PM1
Agniswamy, J; Aoki, M; Bulut, H; Das, D; Ghosh, AK; Hayashi, H; Martyr, CD; Mitsuya, H; Nyalapatla, PR; Osswald, HL; Rao, KV; Wang, YF; Weber, IT1
Ali, A; Henes, M; Kosovrasti, K; Kurt Yilmaz, N; Lee, SK; Lockbaum, GJ; Nalivaika, EA; Rao, DN; Rusere, LN; Schiffer, CA; Spielvogel, E; Swanstrom, R1
Campos L, A; Castro-Moraga, ME; Figueroa V, C; Piñera M, C; Yizmeyián M, A1
Beerenwinkel, N; Günthard, HF; Kouyos, R; Kuipers, J; Montazeri, H; Posada-Céspedes, S; Rhee, SY; Van Zyl, G1
Jarvis, MF; Morris, JB; Mostafa, NM; Munasinghe, WP; Saeed, AM; Schmidt, JM; Vallabh, BK1
Eggers, Y; Feldt, T; Fuchs, A; Häussinger, D; Heger, E; Hurissa, Z; Jarso, G; Jensen, BO; Kaiser, R; Knops, E; Lübke, N; Luedde, T; Orth, HM; Tufa, TB1
Ho, RJY; Perazzolo, S; Shen, DD; Shireman, LM1
Ho, RJY; Perazzolo, S; Shen, DD1
Akelo, V; Angira, F; Chen, H; Coombs, R; Hogg, E; Kosgei, J; Kumwenda, J; McKhann, A; Murphy, SC; Schooley, R; Shaffer, D; Ssali, F; Stewart, VA; Tonui, R1
Andrieux-Meyer, I; Bekker, A; Capparelli, E; Cotton, MF; Cressey, R; Cressey, TR; du Toit, S; Groenewald, M; Kumar, M; Lallemant, M; Nielsen, J; Rabie, H; Salvadori, N; Than-In-At, K1
Dunk, CE; Serghides, L1
Alfaro Martínez, JJ; Sirvent Segovia, AE1
Aidara, M; Alleyo, A; Diallo, K; Manga, NM; Wembulua, BS1
Abdullahi, A; Abdullahi, M; Atiku, A; Dauda, H; Gwamna, J; Ige, O; Kambai, H; Kera, HN; Musa, S; Olasinde, T; Oyefabi, A; Sheyin, J; Sunday, J; Umeh, GC; Usman, I1
Mason, AL; Saxinger, L; Turvey, SL1
Abdelnabi, R; Annaert, PP; Augustijns, PF; Cambier, S; Chatterjee, AK; Coelmont, L; Dallmeier, K; De Jonghe, S; Delang, L; Foo, CS; Gouwy, M; Heylen, E; Jochmans, D; Kaptein, SJF; Leyssen, P; Mols, R; Neyts, J; Proost, P; Rocha-Pereira, J; Ter Horst, S; van Laer, C; Vandooren, J; Vangeel, L; Vergote, V; Weynand, B; Zhang, X1
Au, ICH; Chung, MSH; Cowling, BJ; Kwan, MYW; Kwok, ACY; Lau, EHY; Lau, KTK; Low, MCH; Lui, AYC; Wong, CKH; Xiong, X1
Abdelwahab, MT; Andrieux-Meyer, I; Bekker, A; Chabala, C; Cotton, MF; Davies, G; Denti, P; Hesseling, A; Lee, J; McIlleron, H; Rabie, H; Tikiso, T; Wiesner, L; Zar, HJ1
Abu Khattab, M; Al Maslamani, M; Al Soub, H; Al-Khal, A; Alibrahim, R; Elmekaty, EZI; Elsayed, A; Eltaib, S; Hassanin, R; Mohamed Ibrahim, MI; Rustom, F1
Akpomiemie, G; Christofides, N; Lalla-Edward, S; Machisa, M; Mokgethi, NO1
Cai, WP; Chen, JF; Chen, YY; Dai, LL; He, Y; Hu, JH; Hu, M; Jiang, TY; Li, LH; Liu, L; Liu, X; Lu, HZ; Lu, RJ; Lun, WH; Mu, TT; Peng, HY; Shao, YM; Su, B; Sun, CC; Sun, LJ; Sun, YT; Wang, H; Wang, M; Wang, MX; Wang, Y; Wu, H; Xia, W; Xie, D; Xing, H; Yao, C; Yu, JH; Zhang, FJ; Zhang, T; Zhang, YH; Zhao, M; Zhao, QX; Zheng, QS; Zheng, YH; Zhu, B1
Jacobs, BA; Mtshali, S1
El Maghraby, GM; Essa, EA; Fayed, ND1
Aweeka, F; Ehrlich, H; Freeman, T; French, J; Goodwin, J; Huang, L; Kajubi, R; Kay, K; Li, F; Mwebaza, N; Ou, J; Parikh, S; Riggs, M; Ruiz-Garcia, A; Wade, M; Wang, K1
Avihingsanon, A; Chaivichacharn, P; Gatechompol, S; Punyawudho, B; Ubolyam, S1
Cere, MC; Chatelut, E; Fraissinet, F; Gandia, P; Lavit, M; Oumar, AA; Seraissol, P1
Chen, M; Huobu-Mo, M; Li, C; Li, J; Wu, M; Xiao, H; Zeng, L; Zhang, Y1
Ballesteros, A; Buck, WC; Burger, DM; Chabala, C; Chitsamatanga, M; Colbers, A; Domínguez-Rodríguez, S; Jacobs, TG; Madrid, L; Moraleda, C; Mujuru, HA; Mumbiro, V; Namuziya, N; Nathoo, KJ; Nduna, B; Passanduca, A; Rojo, P; Tagarro, A1
Ajibola, G; Batlang, O; Bennett, K; Capparelli, EV; Hughes, MD; Jean-Philippe, P; Kuritzkes, DR; Lichterfeld, M; Lockman, S; Makhema, J; Maswabi, K; Mohammed, T; Moyo, S; Pretorius-Holme, M; Ricci, L; Sakoi, M; Shapiro, RL1
Boyd, BJ; Clulow, AJ; Hawley, A; Ramirez, G; Salim, M1
Bonfanti, P; Cascio, A; Celesia, BM; Cenderello, G; Costa, C; De Socio, GV; De Vito, A; Di Biagio, A; Falasca, K; Madeddu, G; Martinelli, CV; Menzaghi, B; Molteni, C; Orofino, G; Parruti, G; Pellicanò, GF; Ricci, E; Sarchi, E; Squillace, N; Taramasso, L; Valsecchi, L1
Chen, H; Deng, Y; Gao, Y; Ge, X; Ge, Y; Lan, G; Li, B; Li, S; Liu, S; Luo, H; Luo, L; Meng, Q; Qin, G; Qin, H; Wang, Y; Wen, P; Wu, X; Yang, H; Zhu, J; Zhu, Q1
Eleje, GU; Ikechebelu, JI; Nwagha, UI; Okafor, HU; Ugwu, AO; Ugwu, EO; Umeh, UA1
Bamford, A; Burger, DM; Bwakura-Dangarembizi, M; Chabala, C; Colbers, A; Denti, P; Doerholt, K; Gibb, DM; Griffiths, AL; Makumbi, S; McIlleron, HM; Monkiewicz, LN; Mulenga, V; Mumbiro, V; Musiime, V; Nangiya, J; Szubert, AJ; Waalewijn, H; Wasmann, RE; Wiesner, L1
Bukachi, FO; Makamu, BL; Mwangi, PW1
Gill, MM; Herrera, N; Maile, L; Masenyetse, L; Masitha, M; Mokone, M; Tukei, VJ1
Chabala, C; Choo, L; Chungu, C; Crook, A; Gibb, D; Kapasa, M; LeBeau, K; Lungu, J; McIlleron, H; Mulenga, V; Tembo, CH; Turkova, A; Weisner, L; Zimba, K; Zyambo, K1
Andre, P; Buclin, T; Calmy, A; Decosterd, LA; Delfraysse, M; Fedeli, C; Guidi, M; Thoueille, P; Ustero, P1
Aarnoutse, R; Chabala, C; Cotton, MF; Denti, P; Galileya, LT; Gibb, D; Hesseling, A; Lee, J; McIlleron, H; Njahira Mukui, I; Rabie, H; Turkova, A; Wasmann, RE; Zar, H1
Alabdalaali, MM; Hadi, AM1
Everitt, D; Nedelman, JR; Salinger, DH; Subramoney, V1
Lallemant, M; Lee, J; Marchal, B; Nebot Giralt, A; Nöstlinger, C; Nyamongo, I; Onyango-Ouma, W; Salami, O1
Cecka, F; Cerveny, L; Huliciak, M; Martinec, O; Staud, F; Vokral, I1
Cahn, P; Figueroa, MI; Gun, A; Hull, MW; Kaul, R; Raboud, JM; Rolon, MJ; Sued, O; Szadkowski, L; Tan, DHS; Walmsley, SL1
Blanche, S; Engebretsen, I; Eymard-Duvernay, S; Flück, CE; Foissac, F; Hartmann, MF; Hirt, D; Kankasa, C; Kariyawasam, D; Meda, N; Molès, JP; Mwiya, M; Nagot, N; Peries, M; Polak, M; Singata-Madliki, M; Treluyer, JM; Tumwine, J; Tylleskär, T; Van De Perre, P; Wudy, SA1
Dai, L; Li, J; Liu, A; Mahajan, SD; Schwartz, SA; Scott, SR; Shao, Y; Su, B; Sun, L; Wu, H; Ye, J; Yu, H; Zhang, H; Zhang, T1
Karbwang, J; Na-Bangchang, K; Rajoli, RKR; Saeheng, T; Siccardi, M1
Collier, AC; de Jesus, CS; Godfrey, C; Grinsztejn, B; Gross, R; Hogg, E; Hovind, L; Hughes, MD; Mellors, JW; Mngqibisa, R; Mugyenyi, P; Ritz, J; Salata, R; Saravanan, S; van Schalkwyk, M; Viana, R; Wallis, CL; Wieclaw, L1
Decloedt, EH; Engelbrecht, AE; Norman, J; Rabie, H; Wiesner, L1
Barreto, J; Borrego, P; Gomes, P; Gonçalves, F; Moranguinho, I; Rocha, J; Taveira, N1
Chi, BH; Fairlie, L; Farhad, M; Fenton, T; Fowler, MG; Moodley, D; Naik, S; Nakabiito, C; Stringer, JSA; Venkatesh, KK1
Fischer, A; Gumede, SB; Lalla-Edward, ST; Venter, WDF1
Aizire, J; Brooks, KM; Butler, K; Cababasay, M; Fenton, T; Flynn, PM; Fowler, MG; Kiser, JJ; Mirochnick, M; Siberry, GK1
Ebrahim, I; Maartens, G; McIlleron, H; Orrell, C; Smythe, W; Wiesner, L1
Collier, AC; Ho, RJY; Kinman, L; Koehn, J; Lane, S; Lee, W; McConnachie, LA; Perazzolo, S; Shen, DD; Shireman, LM1
Coelho, L; Collier, AC; Fletcher, CV; Godfrey, C; Grinsztejn, B; Gross, R; Hogg, E; Hughes, MD; Matoga, M; Mngqibisa, R; Mumbi, ME; Poongulali, S; Ritz, J; Salata, R; Van Schalkwyk, M; Wallis, CL1
Aweeka, FT; Barnes, KI; Byakika-Kibwika, P; Bygbjerg, IC; Chijioke-Nwauche, I; Denti, P; Francis, J; Hoglund, RM; Khoo, SH; Kredo, T; Lamorde, M; Lemnge, MM; Merry, C; Nyagonde, N; Parikh, S; Scarsi, KK; Sutherland, CJ; Tarning, J; Vestergaard, LS; Walimbwa, SI; Workman, L1
Andrieux-Meyer, I; Bobat, R; Cotton, M; Denti, P; Fairlie, L; Lallemant, M; Lee, J; Liberty, A; McIlleron, H; Rabie, H; Strehlau, R; Tikiso, T1
Cao, Y; Xu, S; Zhou, M; Zhu, F1
Abbasnezhad, A; Abd El-Ghafar, OA; Abhilash, L; Abouzid, KAM; Achberger, AM; Ackerman, S; Akhatayeva, Z; Akin, D; Al-Kaysi, RO; Alakhdar, AA; Alame, M; Aleksic Sabo, V; Alinezhadbalalami, N; Allen, JD; Alonso, JM; Alqatani, S; Alsayed, B; Álvarez Larraondo, M; Alvarez, M; Amini, SB; An, Z; Anasir, MI; Anderson, GH; Andremont, A; Andrés, S; Angel, S; Anigboro, AA; Anini, Y; Antonides, CFJ; Arafa, K; Arafa, RK; Aryal, UK; Asbaghi, O; Assefa, MK; Atyah, M; Avwioroko, OJ; Ayora-Talavera, G; Azpilikueta, A; Azyazov, VN; Ba, YF; Bachmann, KF; Badoual, J; Bae, SJ; Baek, SH; Bahrami, B; Bai, J; Baid-Agrawal, S; Bailey, MR; Baillie, JK; Balani, N; Balcar, VJ; Banica, T; Banks, L; Barb, J; Bardeen, CJ; Barrett, HE; Bartnikowski, N; Bashir, R; Battaglia, M; Bautista-Hernández, V; Becker, B; Beekman, FJ; Benidir, M; Benjelloun, M; Bentley, RF; Bergé, J; Berger, D; Bernsen, MR; Berraondo, P; Bhattacharya, R; Bhayani, SB; Bi, W; Bi, X; Bi, YL; Bi, Z; Bian, K; Biesecker, LG; Billadeau, DD; Blaszczyk, R; Blum, JL; Boachie, R; Boelte, K; Bogers, AJJC; Boileau, I; Bonduelle, C; Bonny, O; Bonsu, JM; Boos, LA; Borges-Argáez, R; Bouchard, PA; Boudot, C; Bourgeade-Delmas, S; Boutet-Robinet, E; Boyle, AJ; Branigan, D; Briones, S; Broniowska, KA; Brossas, JY; Brown, WA; Brzezinska, J; Buitron, G; Burnier, M; Bursulaya, B; Burton, PR; Bush, AA; Busuttil, RW; Cabello-Aguilar, S; Cáceres-Farfán, M; Cacheux, V; Caffrey, PJ; Cai, B; Cai, Q; Cai, S; Cai, Y; Calders, P; Cammarota, G; Campbell, DA; Cancelli, C; Cao, Q; Cao, WH; Cao, X; Capet, M; Capoluongo, E; Carey, ME; Carnero, M; Carrasco, LI; Carreno, J; Carrillo-Reyes, J; Casini, I; Cassar, M; Catalan, G; Cattamanchi, A; Cazares-Granillo, M; Celie, B; Cen, YK; Cena, H; Cerbo, RM; Ceron, E; Cetina-Montejo, L; Chaâbane-Banaoues, R; Chabanet, C; Chace-Donahue, F; Chalfun-Júnior, A; Chan-Balan, R; Chang, CS; Chen, CS; Chen, D; Chen, J; Chen, L; Chen, PN; Chen, Q; Chen, S; Chen, W; Chen, WP; Chen, X; Chen, Z; Cheng, H; Cheng, J; Cheng, Q; Cheng, T; Chi, T; Chianelli, D; Chieppa, M; Child, CJ; Cho, JH; Cho, JY; Chogtu, B; Choi, GH; Choi, J; Choi, M; Choi, NG; Cholu, CO; Chow, ES; Chowdhury, AH; Chu, PC; Chu, Q; Chu, S; Chua, H; Chung, T; Chunyan, L; Church, JS; Civardi, E; Cobiella, J; Colinge, J; Collado, CJ; Collins, TJ; Cong, LM; Conkrite, KL; Cope, SJ; Corbett, JA; Cornet, M; Cornillot, E; Corvaisier, S; Costes-Martineau, V; Courtioux, B; Coussens, M; Covino, M; Criado, A; Cui, J; Cui, Y; Cunitz, BW; Curry, AE; Cussó, L; D'Urzo, AD; D'Urzo, KA; Dabbous, S; Dahlgren, RA; Dai, H; Dai, T; Dai, W; Dalinghaus, M; Dang, S; Davalos, RV; Davidson, H; de Andrea, CE; De Angelis, M; de Blois, E; de Carvalho, PA; De Clercq, E; De Giuseppe, R; de Jong, M; De Langhe, S; De Oliveira, L; de Souza Pinto Lemgruber, R; de Souza, LB; de Swart, J; De Wandele, I; de Woestijne, PCV; Delaney, S; Delorme, M; Delvenne, P; Deng, L; Deng, Z; Denkinger, CM; der Meulen, MHV; Deraeve, C; Desco, M; DeSilva, S; Destere, A; Dhali, A; Di Ciano, P; Dias-Santagata, D; Diskin, SJ; Djè, MK; Doddipatla, S; Doerr, AJ; Dokla, EME; Domiciano, D; Domingo, N; Dong, C; Dong, J; Dong, Q; Dong, S; Dong, X; Dong, Z; Douair, I; Douglas, TA; Doyle, SM; Drain, PK; Du, K; Du, L; Du, Q; Du, S; Duan, C; Duan, H; Duan, J; Duan, S; Duan, W; Dueluzeau, R; Dukic, L; Dunmire, BL; Duvauchelle, T; Dymek, B; Dzwonek, K; Earnest, A; Eckardt, KU; El Ghadraoui, L; El Massoudi, S; Elloumi, F; Elnour, IE; Embarak, S; Ende, M; England, K; Enikeev, D; Enyedy, I; Epple, R; Erickson, GE; Eriksson, J; Erndt-Marino, J; Errachidi, F; Etxeberria, I; Evan, AP; Fairlamb, AH; Falahi, E; Fan, CC; Fan, H; Fan, M; Fan, MZ; Fan, S; Fan, Y; Fang, CS; Fang, J; Fang, X; Fang, Z; Farmany, A; Farooqi, A; Farouk, HO; Fazelipour, S; Feng, D; Feng, J; Feng, JX; Feng, YL; Ferraz, SL; Ferreira, CR; Figenshau, RS; Finn, AV; Fiseha, T; Fleischer, AS; Fogleman, AD; Fontaine, O; Ford, CR; Fouladvand, F; Four, M; Fousteri, G; Francis, JR; Fraser, JF; Frazier, RP; Fu, H; Fu, P; Fu, YJ; Fujishima, A; Fuster, V; Gabilan, JC; Gagliani, N; Gai, QY; Galán-Arriola, C; Gale, P; Galimova, GR; Galkin, A; Gallo, A; Gallo, AA; Gang, DD; Ganschow, S; Gao, C; Gao, F; Gao, GP; Gao, H; Gao, K; Gao, M; Gao, MY; Gao, P; Gao, R; Gao, S; Gao, WJ; Gao, Y; Garbacz, P; García Ruiz, L; Garcia, EM; Garofoli, F; Gasbarrini, A; Gattinoni, L; Gaudig, M; Gbureck, U; Ge, X; Genko, N; Gentile, GL; George, MW; Gerety, GF; Gestwicki, JE; Geusens, PP; Ghassemi, M; Giardina, JD; Giebultowicz, JM; Gifford, CA; Gijsen, FJH; Gilfillan, R; Gilson, E; Gingl, K; Giuliano, C; Glybochko, P; Goessler, W; Gofflot, S; Golab, J; Goldstein, A; Golebiowski, A; Gómez, L; Gómez-Carballo, J; Gonçalves, PEO; Gonzales, R; Gonzalez-Cotto, M; González-Fernández, D; Gonzalez-Lopez de Turiso, F; Goodman, JM; Govinda Raju, S; Grimm, J; Gross, AJ; Gruenheid, S; Gu, C; Gu, FF; Gu, S; Gu, Z; Guest, RL; Gui, C; Gui, J; Guillem, A; Guo, G; Guo, L; Guo, Q; Guo, S; Guo, SW; Guo, W; Guo, Y; Guo, YG; Guo, Z; Guretzky, JA; Haenggi, M; Hahn, MS; Hakkola, J; Halim, AA; Hampel, D; Han, B; Han, BH; Han, D; Han, G; Han, J; Han, LZ; Han, R; Han, S; Han, X; Han, Z; Handley, MA; Hanke, I; Hannongbua, S; Hao, P; Happ, JT; Hara, M; Haraux, F; Hare, JL; Harper, JD; Hartley, AM; Harvey, E; Hashimoto, K; Hassan, HM; Hautajärvi, H; Hayton, TW; He, C; He, H; He, HJ; He, WP; He, Y; He, Z; Hedrick, V; Heffernan, JK; Hegrová, J; Heidarimoghadam, R; Helms, K; Hengphasatporn, K; Henry, D; Herrmann, TRW; Hesson, T; Himmelbauer, MK; Hindle, A; Hoffmann, R; Hogg, N; Hong, KB; Hong, SK; Honjol, Y; Hood, C; Hsi, RS; Hsu, JL; Hu, B; Hu, BC; Hu, D; Hu, H; Hu, J; Hu, K; Hu, M; Hu, MK; Hu, T; Hu, W; Hu, Y; Hu, Z; Hua, S; Huang, H; Huang, J; Huang, L; Huang, M; Huang, P; Huang, X; Huang, Y; Huang, Z; Hukkanen, J; Hung, MC; Huo, X; Hyötyläinen, T; Ianiro, G; Ibanez, B; Imran, M; Ireland, S; Irwin, MS; Ishiguro, H; Jackowski, K; Jackson, C; Jacob, SI; Jahromy, MH; Jakob, SM; Jang, J; Javvaji, PK; Jefferson, KK; Jena, P; Ji, H; Jiang, F; Jiang, GH; Jiang, H; Jiang, J; Jiang, X; Jiang, Z; Jiao, J; Jiménez, A; Jin, X; Jincai, W; Jintao, X; Jo, K; Jofra, T; Johari, Y; Johnson, ACM; Jones, JH; Josephine Fauci, A; Juhl, AK; Jun, S; Kaiser, RI; Kajioka, J; Kajiyama, H; Kalliyil, A; Kalthur, SG; Kamalanathan, M; Kamaldinov, T; Kanaani, L; Kang, D; Kang, J; Kang, S; Känsäkoski, P; Kaplan, DL; Karwan, M; Kasibhatla, S; Kaur, A; Kawazoe, Y; Ke, C; Keyser, J; Khalique, A; Khan, IT; Kharshoum, RM; Kher, R; Kherani, J; Ki, KK; Kikkawa, F; Kikkawa, R; Kim, BT; Kim, EH; Kim, GA; Kim, GD; Kim, HB; Kim, HG; Kim, JS; Kim, MJ; Kim, SI; Kim, SJ; Kim, Y; King, K; Kinyamu-Akunda, J; Kirkkala, T; Kjaer-Sorensen, K; Kleppinger, EL; Kloner, RA; Klopfenstein, TJ; Knappe, D; Knezevic, P; Kobos, LM; Kohli, M; Kolano, L; Kolodgie, FD; Kolte, AP; Koneru, B; Kong, D; Kong, F; Kong, X; Konggidinata, MI; Köpke, M; Koski, KG; Kotsis, F; Köttgen, A; Kouakou-Kouamé, CA; Kraemer, US; Krane, V; Krehbiel, CR; Krenning, BJ; Kretzschmar, D; Ku, KB; Kubota, Y; Kulich, P; Kumar, NG; Kupiec-Weglinski, JW; Lalani, SS; Lan, X; Landfeldt, E; Langenberg, E; Lapauw, B; Larkin, J; Lassoued, MA; Laukhtina, E; Laura Martinez, J; Laveillé, A; Lavela, P; Law, AD; Lazraq, A; Le Foll, B; Lee, BK; Lee, C; Lee, CS; Lee, EJ; Lee, EY; Lee, G; Lee, HY; Lee, JH; Lee, JJ; Lee, JO; Lee, JS; Lee, R; Lei, H; Lei, P; Lellouche, F; Lennerz, JK; Leong, W; Leslie, I; Lessem, E; Levin, M; Levinger, I; Li, C; Li, CW; Li, CX; Li, CY; Li, D; Li, H; Li, HM; Li, J; Li, L; Li, LM; Li, N; Li, S; Li, W; Li, X; Li, XX; Li, Y; Li, Z; Li, ZL; Li, ZX; Lian, Q; Liang, C; Liang, GH; Liang, H; Liang, J; Liang, X; Liao, CX; Liao, R; Ličbinský, R; Lim, YS; Lima, HK; Lin, JG; Lin, L; Lin, S; Lin, WP; Lin, Z; Liso, M; Liu, BX; Liu, C; Liu, H; Liu, J; Liu, M; Liu, Q; Liu, S; Liu, SF; Liu, SL; Liu, T; Liu, W; Liu, X; Liu, XB; Liu, Y; Liu, YY; Liu, Z; Liu, ZQ; Lobo, M; Loitzenbauer, M; López, F; Lopez, G; López, GJ; Lou, Z; Lu, IC; Lu, J; Lu, M; Lu, W; Lu, X; Lu, Y; Luhovyy, BL; Luna-Abanto, J; Luo, J; Luo, K; Luo, L; Luo, M; Luo, W; Luo, X; Luo, XM; Lv, Y; 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Edmunds-Ogbuokiri, J1
Murphy, MJ1
Benson, CA; Brun, SC; Deeks, SG; Eron, JJ; Feinberg, J; Gulick, RM; Hicks, C; Hsu, A; Japour, AJ; Kempf, D; Kessler, HA; King, M; Murphy, RL; Real, K; Riddler, S; Sax, PE; Stryker, R; Sun, E; Thompson, M; Wheeler, D1
Morlese, JF; Pozniak, AL; Qazi, NA1
Eyer-Silva, WA; Morais-De-Sá, CA; Neves-Motta, R; Pinto, JF1
Back, DJ; Barry, M; Bergin, C; Boyle, N; Clarke, S; Mulcahy, F; Reynolds, H1
Brill, M; Farthing, C; Graham, E; Khanlou, H1
Alexander, C; Harris, M; Montaner, JS; O'Shaughnessy, M1
Edno-Mcheik, L; Lagrange, F; Molimard, M; Moore, N; Péhourcq, F; Titier, K1
Han, L; Hsu, A; Kempf, DJ; Lin, CT; Mo, H; Molla, A; Vasavanonda, S1
Hammer, SM1
Arribas, J; Beall, G; Bernstein, B; Brun, S; Japour, A; Johnson, D; Johnson, M; King, M; Lalonde, R; Ruane, P; Sun, E; Walmsley, S1

Reviews

69 review(s) available for lopinavir and HIV Coinfection

ArticleYear
Protease inhibitor-based antiretroviral therapy in pregnancy: effects on hormones, placenta, and decidua.
    The lancet. HIV, 2022, Volume: 9, Issue:2

    Topics: Anti-HIV Agents; Child; Decidua; Female; HIV Infections; HIV Protease Inhibitors; Humans; Infant, Newborn; Lopinavir; Placenta; Pregnancy; Progesterone; Protease Inhibitors; Ritonavir

2022
Apples to Apples? A Comparison of Real-World Tolerability of Antiretrovirals in Patients with Human Immunodeficiency Virus Infection and Patients with Primary Biliary Cholangitis.
    Viruses, 2022, 03-03, Volume: 14, Issue:3

    Topics: Anti-HIV Agents; Anti-Retroviral Agents; Betaretrovirus; HIV Infections; HIV Protease Inhibitors; Humans; Liver Cirrhosis, Biliary; Lopinavir; Malus; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors

2022
Population pharmacokinetics of ethambutol in African children: a pooled analysis.
    The Journal of antimicrobial chemotherapy, 2022, 06-29, Volume: 77, Issue:7

    Topics: Anti-HIV Agents; Antitubercular Agents; Child; Child, Preschool; Ethambutol; HIV Infections; Humans; Infant, Newborn; Lopinavir; Ritonavir

2022
Antivirals for prevention of hepatitis B virus mother-to-child transmission in human immunodeficiency virus positive pregnant women co-infected with hepatitis B virus.
    The Cochrane database of systematic reviews, 2023, 06-12, Volume: 6

    Topics: Antiviral Agents; Coinfection; DNA, Viral; Emtricitabine; Female; Hepatitis B e Antigens; Hepatitis B virus; HIV; HIV Infections; HIV Seropositivity; Humans; Infant; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Pregnancy; Pregnant Women; Ritonavir; Tenofovir; Zidovudine

2023
An Individual Participant Data Population Pharmacokinetic Meta-analysis of Drug-Drug Interactions between Lumefantrine and Commonly Used Antiretroviral Treatment.
    Antimicrobial agents and chemotherapy, 2020, 04-21, Volume: 64, Issue:5

    Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Antimalarials; Antiretroviral Therapy, Highly Active; Artemether, Lumefantrine Drug Combination; Body Weight; Computer Simulation; Drug Interactions; Female; HIV Infections; Humans; Lopinavir; Lumefantrine; Malaria; Male; Middle Aged; Monte Carlo Method; Ritonavir; Young Adult

2020
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma, Mantle-Cell; Lysosomes; Macrophages; Male; Manganese Compounds; MAP Kinase Kinase 4; Mass Screening; Maternal Health; Medicine, Chinese Traditional; Melanoma, Experimental; Memantine; Membrane Glycoproteins; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Metal Nanoparticles; Metalloendopeptidases; Metalloporphyrins; Methadone; Methane; Methicillin-Resistant Staphylococcus aureus; Mexico; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Nude; Mice, SCID; Mice, Transgenic; Microarray Analysis; Microbial Sensitivity Tests; Microbiota; Micronutrients; MicroRNAs; Microscopy, Confocal; Microsomes, Liver; Middle Aged; Milk; Milk, Human; Minority Groups; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Epidemiology; Molecular Structure; Molecular Weight; Multilocus Sequence Typing; Multimodal Imaging; Muscle Strength; Muscle, Skeletal; Muscular Diseases; Mutation; Mycobacterium tuberculosis; Myocardial Stunning; Myristates; NAD(P)H Dehydrogenase (Quinone); Nanocomposites; Nanogels; Nanoparticles; Nanotechnology; Naphthalenes; Nasal Cavity; National Health Programs; Necrosis; Needs Assessment; Neoadjuvant Therapy; Neonicotinoids; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplastic Stem Cells; Netherlands; Neuroblastoma; Neuroprotective Agents; Neutrophils; NF-kappa B; NFATC Transcription Factors; Nicotiana; Nicotine; Nitrates; Nitrification; Nitrites; Nitro Compounds; Nitrogen; Nitrogen Dioxide; North Carolina; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Nucleic Acid Hybridization; Nucleosomes; Nutrients; Obesity; Obesity, Morbid; Oceans and Seas; Oncogene Protein v-akt; Oncogenes; Oocytes; Open Reading Frames; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Outpatients; Ovarian Neoplasms; Ovariectomy; Overweight; Oxazines; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxides; Oxidoreductases; Oxygen; Oxygen Inhalation Therapy; Oxygenators, Membrane; Ozone; Paclitaxel; Paenibacillus; Pain Measurement; Palliative Care; Pancreatic Neoplasms; Pandemics; Parasympathetic Nervous System; Particulate Matter; Pasteurization; Patient Preference; Patient Satisfaction; Pediatric Obesity; Permeability; Peroxiredoxins; Peroxynitrous Acid; Pharmaceutical Services; Pharmacists; Pharmacy; Phaseolus; Phenotype; Phoeniceae; Phosphates; Phosphatidylinositol 3-Kinases; Phospholipid Transfer Proteins; Phospholipids; Phosphorus; Phosphorylation; Photoperiod; Photosynthesis; Phylogeny; Physical Endurance; Physicians; Pilot Projects; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plaque, Atherosclerotic; Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus

2016
Pharmacokinetics of antiretroviral and tuberculosis drugs in children with HIV/TB co-infection: a systematic review.
    The Journal of antimicrobial chemotherapy, 2020, 12-01, Volume: 75, Issue:12

    Topics: Anti-HIV Agents; Child; Child, Preschool; Coinfection; HIV Infections; Humans; Lopinavir; Pharmaceutical Preparations; Tuberculosis

2020
Atazanavir / ritonavir versus Lopinavir / ritonavir-based combined antiretroviral therapy (cART) for HIV-1 infection: a systematic review and meta-analysis.
    African health sciences, 2020, Volume: 20, Issue:1

    Topics: Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Hyperbilirubinemia; Lopinavir; Ritonavir; Treatment Outcome; Viral Load

2020
Lopinavir/ritonavir: Repurposing an old drug for HIV infection in COVID-19 treatment.
    Biomedical journal, 2021, Volume: 44, Issue:1

    Topics: Animals; Clinical Trials as Topic; COVID-19 Drug Treatment; Drug Combinations; Drug Repositioning; HIV Infections; Humans; Lopinavir; Ritonavir; SARS-CoV-2

2021
Lopinavir/Ritonavir: A Review of Analytical Methodologies for the Drug Substances, Pharmaceutical Formulations and Biological Matrices.
    Critical reviews in analytical chemistry, 2022, Volume: 52, Issue:8

    Topics: COVID-19 Drug Treatment; Drug Compounding; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Ritonavir

2022
Abacavir pharmacokinetics in African children living with HIV: A pooled analysis describing the effects of age, malnutrition and common concomitant medications.
    British journal of clinical pharmacology, 2022, Volume: 88, Issue:2

    Topics: Anti-HIV Agents; Child; Child, Preschool; Dideoxynucleosides; HIV Infections; Humans; Infant, Newborn; Lopinavir; Malnutrition; Ritonavir

2022
Efficacy and safety of atazanavir/ritonavir-based antiretroviral therapy for HIV-1 infected subjects: a systematic review and meta-analysis.
    Archives of virology, 2017, Volume: 162, Issue:8

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; CD4 Lymphocyte Count; Darunavir; HIV Infections; HIV-1; Humans; Lopinavir; Randomized Controlled Trials as Topic; Ritonavir; RNA, Viral; Treatment Outcome; Viral Load

2017
Comparative efficacy and safety of second-line antiretroviral therapy for treatment of HIV/AIDS: a systematic review and network meta-analysis.
    The lancet. HIV, 2017, Volume: 4, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Anti-HIV Agents; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Network Meta-Analysis; Prospective Studies; Raltegravir Potassium; Retrospective Studies; Reverse Transcriptase Inhibitors; Ritonavir

2017
Antiretroviral therapy for pregnant women living with HIV or hepatitis B: a systematic review and meta-analysis.
    BMJ open, 2017, Sep-11, Volume: 7, Issue:9

    Topics: Adult; Anti-Retroviral Agents; Drug Combinations; Emtricitabine; Female; Hepatitis B; HIV Infections; Humans; Infant; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Ritonavir; Tenofovir; Young Adult; Zidovudine

2017
Regression of human immunodeficiency virus-associated oral Kaposi sarcoma with combined antiretroviral therapy: A case report and literature review.
    Head & neck, 2019, Volume: 41, Issue:2

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Combinations; HIV Infections; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Mouth Neoplasms; Ritonavir; Sarcoma, Kaposi; Zidovudine

2019
Clinical pharmacokinetics of antiretroviral drugs in older persons.
    Expert opinion on drug metabolism & toxicology, 2013, Volume: 9, Issue:5

    Topics: Adult; Aged; Anti-HIV Agents; Atazanavir Sulfate; Dose-Response Relationship, Drug; Drug Interactions; Guidelines as Topic; HIV Infections; HIV Protease Inhibitors; Humans; Kidney; Lamivudine; Liver; Lopinavir; Middle Aged; Oligopeptides; Pyridines; Young Adult

2013
Optimisation of antiretroviral therapy in HIV-infected children under 3 years of age.
    The Cochrane database of systematic reviews, 2014, May-22, Issue:5

    Topics: Anti-HIV Agents; CD4 Lymphocyte Count; Disease Progression; Drug Administration Schedule; Drug Combinations; HIV Infections; Humans; Induction Chemotherapy; Infant; Infectious Disease Transmission, Vertical; Lopinavir; Maintenance Chemotherapy; Nevirapine; Ritonavir

2014
Antiretroviral therapy response among HIV-2 infected patients: a systematic review.
    BMC infectious diseases, 2014, Aug-26, Volume: 14

    Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Retroviral Agents; CD4 Lymphocyte Count; Clinical Trials as Topic; Female; HIV Infections; HIV-2; Humans; Indinavir; Lopinavir; Male; Middle Aged; Nelfinavir; Ritonavir; Treatment Outcome

2014
48-week efficacy and safety of dolutegravir relative to commonly used third agents in treatment-naive HIV-1-infected patients: a systematic review and network meta-analysis.
    PloS one, 2014, Volume: 9, Issue:9

    Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Heterocyclic Compounds, 3-Ring; HIV Infections; HIV-1; Humans; Lamivudine; Lipids; Lopinavir; Nitriles; Organophosphonates; Oxazines; Piperazines; Pyridones; Pyrimidines; Pyrrolidinones; Raltegravir Potassium; Randomized Controlled Trials as Topic; Rilpivirine; Ritonavir; Tenofovir; Time Factors; Treatment Outcome; Viral Load

2014
[Efficacy of initial antiretroviral therapy based on lopinavir/ritonavir plus 2 nucleoside/nucleotide analogs in patients with human immunodeficiency virus type 1 infection].
    Enfermedades infecciosas y microbiologia clinica, 2014, Volume: 32 Suppl 3

    Topics: Anti-HIV Agents; Clinical Trials, Phase III as Topic; Double-Blind Method; Drug Combinations; Drug Resistance, Viral; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Ritonavir; Therapeutic Equivalency

2014
[Lopinavir/ritonavir in new initial antiretroviral treatment strategies].
    Enfermedades infecciosas y microbiologia clinica, 2014, Volume: 32 Suppl 3

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Combinations; HIV Infections; HIV Integrase Inhibitors; HIV Protease Inhibitors; Humans; Lopinavir; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Ritonavir; Therapies, Investigational

2014
[Lopinavir/ritonavir in patients with human immunodeficiency virus infection in special situations].
    Enfermedades infecciosas y microbiologia clinica, 2014, Volume: 32 Suppl 3

    Topics: AIDS Dementia Complex; Chemical and Drug Induced Liver Injury; Drug Combinations; Hepatitis, Viral, Human; HIV Infections; HIV Integrase Inhibitors; HIV Protease Inhibitors; HIV-1; HIV-2; Humans; Lopinavir; Renal Insufficiency; Reverse Transcriptase Inhibitors; Ritonavir; Subarachnoid Space

2014
[Lopinavir/ritonavir in human immunodeficiency virus-infected women].
    Enfermedades infecciosas y microbiologia clinica, 2014, Volume: 32 Suppl 3

    Topics: Anti-HIV Agents; Body Size; Drug Combinations; Female; HIV Infections; HIV Integrase Inhibitors; HIV Protease Inhibitors; HIV-Associated Lipodystrophy Syndrome; Humans; Infectious Disease Transmission, Vertical; Lopinavir; Meta-Analysis as Topic; Multicenter Studies as Topic; Patient Selection; Pregnancy; Pregnancy Complications, Infectious; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Ritonavir; Sex Characteristics

2014
Efficacy and biological safety of lopinavir/ritonavir based anti-retroviral therapy in HIV-1-infected patients: a meta-analysis of randomized controlled trials.
    Scientific reports, 2015, Feb-23, Volume: 5

    Topics: Adult; Anti-HIV Agents; Birth Weight; Cholesterol; Databases, Factual; Female; HIV Infections; Humans; Infant, Newborn; Lopinavir; Pregnancy; Premature Birth; Randomized Controlled Trials as Topic; Ritonavir; Treatment Outcome

2015
Choice of antiretroviral drugs for postexposure prophylaxis for adults and adolescents: a systematic review.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015, Jun-01, Volume: 60 Suppl 3

    Topics: Adolescent; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Therapy, Combination; Emtricitabine; HIV; HIV Infections; Humans; Lopinavir; Post-Exposure Prophylaxis; Ritonavir; Tenofovir; World Health Organization

2015
Choice of antiretroviral drugs for postexposure prophylaxis for children: a systematic review.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015, Jun-01, Volume: 60 Suppl 3

    Topics: Anti-HIV Agents; Child; Child, Preschool; Cohort Studies; Dideoxynucleosides; Drug Combinations; Female; HIV Infections; Humans; Infant; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Nevirapine; Post-Exposure Prophylaxis; Pregnancy; Prospective Studies; Randomized Controlled Trials as Topic; Ritonavir; Zidovudine

2015
Efficacy and safety of abacavir-containing combination antiretroviral therapy as first-line treatment of HIV infected children and adolescents: a systematic review and meta-analysis.
    BMC infectious diseases, 2015, Oct-26, Volume: 15

    Topics: Adolescent; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Child; Child, Preschool; Cohort Studies; Cyclopropanes; Dideoxynucleosides; Drug Therapy, Combination; Female; HIV Infections; Humans; Infant; Lopinavir; Male; Ritonavir; Stavudine

2015
Efficacy of protease inhibitor monotherapy vs. triple therapy: meta-analysis of data from 2303 patients in 13 randomized trials.
    HIV medicine, 2016, Volume: 17, Issue:5

    Topics: Atazanavir Sulfate; Cerebrospinal Fluid; Darunavir; Drug Administration Schedule; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Randomized Controlled Trials as Topic; Ritonavir; RNA, Viral; Treatment Outcome

2016
Prediction of area under the concentration-time curve for lopinavir from peak or trough lopinavir concentrations in patients receiving lopinavir-ritonavir therapy.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2016, Mar-15, Volume: 73, Issue:6

    Topics: Anti-HIV Agents; Area Under Curve; Clinical Trials as Topic; Drug Interactions; Drug Therapy, Combination; Forecasting; HIV Infections; HIV Protease Inhibitors; Humans; Linear Models; Lopinavir; Ritonavir

2016
Managing chronic kidney disease in the older adults living with HIV.
    Current opinion in infectious diseases, 2017, Volume: 30, Issue:1

    Topics: Adult; Aged; Anti-HIV Agents; Atazanavir Sulfate; Chronic Disease; Darunavir; Drug Substitution; HIV Infections; Humans; Kidney; Kidney Diseases; Lopinavir; Middle Aged; Tenofovir

2017
Lopinavir/ritonavir: a protease inhibitor for HIV-1 treatment.
    Expert opinion on pharmacotherapy, 2008, Volume: 9, Issue:13

    Topics: Antiretroviral Therapy, Highly Active; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Drug Resistance, Viral; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Patient Compliance; Pyrimidinones; Randomized Controlled Trials as Topic; Ritonavir

2008
HIV monotherapy with ritonavir-boosted protease inhibitors: a systematic review.
    AIDS (London, England), 2009, Jan-28, Volume: 23, Issue:3

    Topics: Atazanavir Sulfate; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lopinavir; Oligopeptides; Pyridines; Pyrimidinones; Ritonavir; RNA, Viral; Treatment Outcome; Viral Load

2009
[Safety and tolerability of darunavir].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 10

    Topics: Adult; Chemical and Drug Induced Liver Injury; Clinical Trials, Phase III as Topic; Darunavir; Drug Therapy, Combination; Dyslipidemias; Female; Gastrointestinal Diseases; HIV Infections; HIV Protease Inhibitors; Humans; Incidence; Lopinavir; Male; Multicenter Studies as Topic; Pyrimidinones; Randomized Controlled Trials as Topic; Ritonavir; Salvage Therapy; Sulfonamides

2008
[Resistance to darunavir].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 10

    Topics: Adult; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Darunavir; Dose-Response Relationship, Drug; Drug Resistance, Viral; Female; HIV; HIV Infections; HIV Protease; HIV Protease Inhibitors; Humans; Lopinavir; Male; Multicenter Studies as Topic; Mutagenesis, Site-Directed; Mutation, Missense; Nitriles; Phenotype; Point Mutation; Pyridazines; Pyrimidines; Pyrimidinones; Randomized Controlled Trials as Topic; Sulfonamides

2008
Non-occupational postexposure prophylaxis for HIV: a systematic review.
    Health technology assessment (Winchester, England), 2009, Volume: 13, Issue:14

    Topics: Anti-HIV Agents; Cost-Benefit Analysis; Databases, Bibliographic; Drug Combinations; Drug Therapy, Combination; HIV Infections; HIV Seropositivity; Humans; Lamivudine; Lopinavir; Premedication; Pyrimidinones; Ritonavir; Substance Abuse, Intravenous; Time Factors; Treatment Outcome; Unsafe Sex; Zidovudine

2009
[Monotherapy in treatment-naïve patients].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 16

    Topics: Clinical Trials as Topic; Cost-Benefit Analysis; Drug Combinations; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Randomized Controlled Trials as Topic; Ritonavir; Treatment Outcome; Viral Load; Virus Replication

2008
[Lopinavir/ritonavir monotherapy as a simplification strategy in the treatment of HIV-1 infection].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 16

    Topics: Anti-HIV Agents; Clinical Trials as Topic; Cost Control; Developing Countries; Drug Combinations; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; HIV-1; HIV-Associated Lipodystrophy Syndrome; Humans; Lopinavir; Multicenter Studies as Topic; Pilot Projects; Prospective Studies; Pyrimidinones; Randomized Controlled Trials as Topic; Ritonavir; Treatment Outcome; Viral Load; Viremia; Virus Replication

2008
[Lopinavir/ritonavir monotherapy. Possible indications].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 16

    Topics: Clinical Trials as Topic; Cost-Benefit Analysis; Drug Combinations; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Mitochondria; Pyrimidinones; Randomized Controlled Trials as Topic; Ritonavir; Treatment Outcome; Viral Load; Virus Replication

2008
[Lopinavir/ritonavir monotherapy as a simplification strategy in antiretroviral therapy in clinical practice].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 16

    Topics: Antiretroviral Therapy, Highly Active; Drug Combinations; Drug Resistance, Viral; HIV Infections; HIV Protease; HIV Protease Inhibitors; Humans; Lopinavir; Practice Guidelines as Topic; Pyrimidinones; Retrospective Studies; Ritonavir; Treatment Outcome; Viral Load; Virus Replication

2008
[The "induction-maintenance" strategy].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 16

    Topics: Adipose Tissue; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; HIV-Associated Lipodystrophy Syndrome; Humans; Lamivudine; Lopinavir; Pyrimidinones; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Outcome; Viral Load; Virus Replication; Zidovudine

2008
[Prognostic factors of virological response in patients treated with lopinavir/ritonavir monotherapy].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 16

    Topics: Anemia; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Clinical Trials as Topic; Drug Combinations; Hemoglobins; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Multicenter Studies as Topic; Patient Compliance; Pilot Projects; Prospective Studies; Pyrimidinones; Randomized Controlled Trials as Topic; Risk Factors; Ritonavir; Treatment Outcome; Viral Load

2008
[Lopinavir/ritonavir monotherapy for the treatment of HIV-1 infection: the emergence of resistance].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 16

    Topics: Anti-HIV Agents; Clinical Trials as Topic; Drug Combinations; Drug Resistance, Multiple, Viral; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Incidence; Lopinavir; Mutation, Missense; Pilot Projects; Point Mutation; Pyrimidinones; Randomized Controlled Trials as Topic; Ritonavir; Viremia

2008
[Pharmacoeconomic aspects of lopinavir/ritonavir monotherapy].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 16

    Topics: Anti-HIV Agents; Clinical Trials as Topic; Cost Control; Cost-Benefit Analysis; Direct Service Costs; Drug Combinations; Drug Costs; Drug-Related Side Effects and Adverse Reactions; European Union; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Prescription Fees; Pyrimidinones; Ritonavir; Treatment Outcome

2008
[Penetration in reservoirs].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 16

    Topics: Anti-HIV Agents; Drug Combinations; Female; Genitalia, Male; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Lymphocytes; Lymphoid Tissue; Male; Organ Specificity; Pyrimidinones; Ritonavir; Tissue Distribution; Virus Replication

2008
The CASTLE study: atazanavir/r versus lopinavir/r in antiretroviral-naive patients.
    Expert review of anti-infective therapy, 2009, Volume: 7, Issue:7

    Topics: Adenine; Anti-HIV Agents; Atazanavir Sulfate; Clinical Trials, Phase III as Topic; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV-1; Humans; Lopinavir; Multicenter Studies as Topic; Oligopeptides; Organophosphonates; Pyridines; Pyrimidinones; Randomized Controlled Trials as Topic; Ritonavir; Tenofovir; Treatment Outcome

2009
Lopinavir/Ritonavir: a review of its use in the management of HIV-1 infection.
    Drugs, 2010, Oct-01, Volume: 70, Issue:14

    Topics: Antiretroviral Therapy, Highly Active; Drug Administration Schedule; Drug Combinations; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pyrimidinones; Ritonavir

2010
Broadening the perspective when assessing evidence on boosted protease inhibitor-based regimens for initial antiretroviral therapy.
    Advances in therapy, 2010, Volume: 27, Issue:11

    Topics: Drug Administration Schedule; Drug Combinations; Drug Synergism; Drug-Related Side Effects and Adverse Reactions; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Practice Guidelines as Topic; Pyrimidinones; Ritonavir

2010
Darunavir: an effective protease inhibitor for HIV-infected patients.
    Expert review of anti-infective therapy, 2011, Volume: 9, Issue:6

    Topics: Darunavir; Drug Administration Routes; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Ritonavir; RNA, Viral; Sulfonamides; Treatment Outcome; Viral Load; Virus Replication

2011
HIV-1-resistance-associated mutations after failure of first-line antiretroviral treatment among children in resource-poor regions: a systematic review.
    The Lancet. Infectious diseases, 2011, Volume: 11, Issue:10

    Topics: Adolescent; Africa; Alkynes; Anti-HIV Agents; Asia; Benzoxazines; Child; Child, Preschool; Cross-Sectional Studies; Cyclopropanes; Developing Countries; Drug Resistance, Viral; Female; Health Resources; HIV Infections; HIV-1; Humans; Indinavir; Lamivudine; Latin America; Lopinavir; Male; Mutation; Nevirapine; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Stavudine; Treatment Failure; Viral Load; Zidovudine

2011
[New strategies in the optimisation of lopinavir/ritonavir doses in human immunodeficiency virus-infected patients].
    Enfermedades infecciosas y microbiologia clinica, 2013, Volume: 31, Issue:1

    Topics: Drug Combinations; HIV Infections; Humans; Lopinavir; Practice Guidelines as Topic; Ritonavir

2013
Protease inhibitor monotherapy: what is its role?
    Current HIV/AIDS reports, 2012, Volume: 9, Issue:2

    Topics: Adipose Tissue; Bone Density; Carbamates; Drug Combinations; Drug Resistance, Viral; Furans; HIV Infections; Humans; Lopinavir; Organophosphates; Protease Inhibitors; Ritonavir; Sulfonamides

2012
Effectiveness of antiretroviral therapy in HIV-infected children under 2 years of age.
    The Cochrane database of systematic reviews, 2012, Jul-11, Issue:7

    Topics: Anti-HIV Agents; CD4 Lymphocyte Count; Disease Progression; Drug Administration Schedule; Drug Combinations; HIV Infections; Humans; Infant; Infectious Disease Transmission, Vertical; Lopinavir; Nevirapine; Ritonavir

2012
Protease inhibitor monotherapy as maintenance regimen in patients with HIV infection.
    Current HIV research, 2012, Volume: 10, Issue:8

    Topics: Darunavir; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Maintenance Chemotherapy; Randomized Controlled Trials as Topic; Ritonavir; RNA, Viral; Sulfonamides; Viral Load

2012
Cushing's syndrome in a patient treated by ritonavir/lopinavir and inhaled fluticasone.
    HIV medicine, 2003, Volume: 4, Issue:2

    Topics: Administration, Inhalation; Adult; Androstadienes; Antiviral Agents; Asthma; Biological Availability; Cushing Syndrome; Cytochrome P-450 Enzyme Inhibitors; Drug Therapy, Combination; Fluticasone; Glucocorticoids; HIV Infections; Humans; Lopinavir; Male; Pyrimidinones; Ritonavir

2003
Differentiation of genotypic resistance profiles for amprenavir and lopinavir, a valuable aid for choice of therapy in protease inhibitor-experienced HIV-1-infected subjects.
    The Journal of antimicrobial chemotherapy, 2003, Volume: 52, Issue:3

    Topics: Carbamates; Drug Resistance, Viral; Furans; Genetic Linkage; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Mutation; Phenotype; Pyrimidinones; Sulfonamides

2003
Boosted PIs: competition hots up.
    The AIDS reader, 2003, Volume: 13, Issue:9

    Topics: Atazanavir Sulfate; Drug Administration Schedule; HIV Infections; Humans; Indinavir; Lopinavir; Oligopeptides; Protease Inhibitors; Pyridines; Pyrimidinones; Randomized Controlled Trials as Topic; Saquinavir

2003
Peptidomimetic inhibitors of HIV protease.
    Current topics in medicinal chemistry, 2004, Volume: 4, Issue:10

    Topics: Anti-HIV Agents; Atazanavir Sulfate; Carbamates; Clinical Trials as Topic; Dipeptides; Furans; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lopinavir; Models, Molecular; Molecular Mimicry; Molecular Structure; Nelfinavir; Oligopeptides; Organophosphates; Peptides; Phenylbutyrates; Pyridines; Pyrimidinones; Ritonavir; Saquinavir; Sulfonamides; Urethane

2004
The role of lopinavir/ritonavir (Kaletra) in the management of HIV infected adults.
    Expert review of anti-infective therapy, 2003, Volume: 1, Issue:3

    Topics: Adult; Animals; Anti-Retroviral Agents; HIV Infections; Humans; Lopinavir; Pyrimidinones

2003
Adverse effects of antiretroviral therapy for HIV infection: a review of selected topics.
    Expert opinion on drug safety, 2005, Volume: 4, Issue:2

    Topics: Adenine; Alkynes; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cardiovascular Diseases; Cyclopropanes; Drug Monitoring; Drug Therapy, Combination; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Kidney Diseases; Lopinavir; Metabolic Syndrome; Nevirapine; Organophosphonates; Oxazines; Pyrimidinones; Risk Factors; Tenofovir

2005
Safety of lopinavir/ritonavir for the treatment of HIV-infection.
    Expert opinion on drug safety, 2005, Volume: 4, Issue:3

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Approval; Drug Interactions; HIV Infections; Humans; Lopinavir; Pyrimidinones; Safety

2005
Safety and antiviral activity of lopinavir/ritonavir-based therapy in human immunodeficiency virus type 1 (HIV-1) infection.
    The Journal of antimicrobial chemotherapy, 2005, Volume: 56, Issue:2

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Resistance, Multiple, Viral; HIV Infections; HIV-1; Humans; Lopinavir; Pyrimidinones; Ritonavir

2005
Lopinavir/ritonavir in the treatment of human immunodeficiency virus infection.
    Expert opinion on pharmacotherapy, 2005, Volume: 6, Issue:9

    Topics: Administration, Oral; CD4 Lymphocyte Count; Contraindications; Cytochrome P-450 CYP3A Inhibitors; Dosage Forms; Drug Approval; Drug Combinations; Drug Interactions; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pyrimidinones; Randomized Controlled Trials as Topic; Ritonavir; Viral Load

2005
[Protease inhibitors].
    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 2005, Volume: 79, Issue:12

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Darunavir; Drug Administration Schedule; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Salvage Therapy; Sulfonamides

2005
[Antiretroviral drugs in severe acute respiratory syndrome].
    Presse medicale (Paris, France : 1983), 2006, Volume: 35, Issue:1 Pt 2

    Topics: Anti-HIV Agents; Anti-Retroviral Agents; Antiviral Agents; Clinical Trials as Topic; Cohort Studies; Drug Therapy, Combination; HIV Infections; Humans; Lopinavir; Protease Inhibitors; Pyrimidinones; Ribavirin; Ritonavir; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus; Viral Fusion Proteins

2006
Lopinavir/ritonavir: a review of its use in the management of HIV infection.
    Drugs, 2006, Volume: 66, Issue:9

    Topics: HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir

2006
Lopinavir plus ritonavir: a novel protease inhibitor combination for HIV infections.
    Expert review of anti-infective therapy, 2007, Volume: 5, Issue:1

    Topics: Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pyrimidinones; Ritonavir

2007
Lopinavir/ritonavir: appraisal of its use in HIV therapy.
    Drugs of today (Barcelona, Spain : 1998), 2007, Volume: 43, Issue:4

    Topics: Animals; Drug Combinations; Drug Evaluation, Preclinical; Drug Interactions; Drug Resistance, Viral; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pyrimidinones; Ritonavir

2007
Monotherapy with lopinavir/ritonavir.
    Expert opinion on investigational drugs, 2007, Volume: 16, Issue:5

    Topics: Drug Combinations; Drug Resistance, Multiple, Viral; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir; Treatment Outcome

2007
Lopinavir/ritonavir (ABT-378/r).
    Expert opinion on pharmacotherapy, 2002, Volume: 3, Issue:3

    Topics: Clinical Trials as Topic; Drug Interactions; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones

2002

Trials

368 trial(s) available for lopinavir and HIV Coinfection

ArticleYear
Pharmacokinetics of high-dose lopinavir-ritonavir with and without saquinavir or nonnucleoside reverse transcriptase inhibitors in human immunodeficiency virus-infected pediatric and adolescent patients previously treated with protease inhibitors.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:9

    Topics: Adolescent; Anti-HIV Agents; Child; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Treatment Outcome

2008
Brief Report: No Differences Between Lopinavir/Ritonavir and Nonnucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy on Clearance of Plasmodium falciparum Subclinical Parasitemia in Adults Living With HIV Starting Treatment (A5297).
    Journal of acquired immune deficiency syndromes (1999), 2022, 02-01, Volume: 89, Issue:2

    Topics: Adult; Anti-HIV Agents; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Parasitemia; Plasmodium falciparum; Reverse Transcriptase Inhibitors; Ritonavir

2022
Pharmacokinetics and Safety of the Abacavir/Lamivudine/Lopinavir/Ritonavir Fixed-Dose Granule Formulation (4-in-1) in Neonates: PETITE Study.
    Journal of acquired immune deficiency syndromes (1999), 2022, 03-01, Volume: 89, Issue:3

    Topics: Anti-HIV Agents; Dideoxynucleosides; Drug Therapy, Combination; HIV Infections; Humans; Infant, Newborn; Lamivudine; Lopinavir; Ritonavir

2022
Brief Report: Long-Term Clinical, Immunologic, and Virologic Outcomes Among Early-Treated Children With HIV in Botswana: A Nonrandomized Controlled Clinical Trial.
    Journal of acquired immune deficiency syndromes (1999), 2023, 04-15, Volume: 92, Issue:5

    Topics: Anti-HIV Agents; Anti-Retroviral Agents; Botswana; CD4 Lymphocyte Count; HIV Infections; HIV-1; Humans; Infant; Infant, Newborn; Lopinavir; Nevirapine; RNA; Viral Load

2023
First Pharmacokinetic Data of Tenofovir Alafenamide Fumarate and Tenofovir With Dolutegravir or Boosted Protease Inhibitors in African Children: A Substudy of the CHAPAS-4 Trial.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023, 09-18, Volume: 77, Issue:6

    Topics: Adult; Anti-HIV Agents; Antiviral Agents; Atazanavir Sulfate; Child; Darunavir; Emtricitabine; Fumarates; HIV Infections; Humans; Lopinavir; Protease Inhibitors; Ritonavir; Tenofovir

2023
Association between HIV antiretroviral therapy and preterm birth based on antenatal ultrasound gestational age determination: a comparative analysis.
    AIDS (London, England), 2019, 12-01, Volume: 33, Issue:15

    Topics: Adult; Anti-HIV Agents; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Emtricitabine; Female; Gestational Age; HIV Infections; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Lamivudine; Logistic Models; Lopinavir; Nevirapine; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Premature Birth; Risk; Ritonavir; Tenofovir; Ultrasonography, Prenatal; Young Adult; Zidovudine

2019
Antenatal Intracellular Concentrations of Tenofovir Diphosphate and Emtricitabine Triphosphate and Associations Between Tenofovir Diphosphate and Severe Adverse Pregnancy Outcomes: IMPAACT-PROMISE (1077BF) Trial.
    Journal of acquired immune deficiency syndromes (1999), 2020, 02-01, Volume: 83, Issue:2

    Topics: Adenine; Anti-HIV Agents; Case-Control Studies; Chromatography, Liquid; Drug Combinations; Emtricitabine; Female; HIV Infections; Humans; Logistic Models; Lopinavir; Medication Adherence; Organophosphates; Polyphosphates; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Retrospective Studies; Ritonavir; Tenofovir

2020
Pharmacokinetic profile and safety of adjusted doses of darunavir/ritonavir with rifampicin in people living with HIV.
    The Journal of antimicrobial chemotherapy, 2020, 04-01, Volume: 75, Issue:4

    Topics: Anti-HIV Agents; Darunavir; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Rifampin; Ritonavir

2020
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma, Mantle-Cell; Lysosomes; Macrophages; Male; Manganese Compounds; MAP Kinase Kinase 4; Mass Screening; Maternal Health; Medicine, Chinese Traditional; Melanoma, Experimental; Memantine; Membrane Glycoproteins; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Metal Nanoparticles; Metalloendopeptidases; Metalloporphyrins; Methadone; Methane; Methicillin-Resistant Staphylococcus aureus; Mexico; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Nude; Mice, SCID; Mice, Transgenic; Microarray Analysis; Microbial Sensitivity Tests; Microbiota; Micronutrients; MicroRNAs; Microscopy, Confocal; Microsomes, Liver; Middle Aged; Milk; Milk, Human; Minority Groups; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Epidemiology; Molecular Structure; Molecular Weight; Multilocus Sequence Typing; Multimodal Imaging; Muscle Strength; Muscle, Skeletal; Muscular Diseases; Mutation; Mycobacterium tuberculosis; Myocardial Stunning; Myristates; NAD(P)H Dehydrogenase (Quinone); Nanocomposites; Nanogels; Nanoparticles; Nanotechnology; Naphthalenes; Nasal Cavity; National Health Programs; Necrosis; Needs Assessment; Neoadjuvant Therapy; Neonicotinoids; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplastic Stem Cells; Netherlands; Neuroblastoma; Neuroprotective Agents; Neutrophils; NF-kappa B; NFATC Transcription Factors; Nicotiana; Nicotine; Nitrates; Nitrification; Nitrites; Nitro Compounds; Nitrogen; Nitrogen Dioxide; North Carolina; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Nucleic Acid Hybridization; Nucleosomes; Nutrients; Obesity; Obesity, Morbid; Oceans and Seas; Oncogene Protein v-akt; Oncogenes; Oocytes; Open Reading Frames; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Outpatients; Ovarian Neoplasms; Ovariectomy; Overweight; Oxazines; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxides; Oxidoreductases; Oxygen; Oxygen Inhalation Therapy; Oxygenators, Membrane; Ozone; Paclitaxel; Paenibacillus; Pain Measurement; Palliative Care; Pancreatic Neoplasms; Pandemics; Parasympathetic Nervous System; Particulate Matter; Pasteurization; Patient Preference; Patient Satisfaction; Pediatric Obesity; Permeability; Peroxiredoxins; Peroxynitrous Acid; Pharmaceutical Services; Pharmacists; Pharmacy; Phaseolus; Phenotype; Phoeniceae; Phosphates; Phosphatidylinositol 3-Kinases; Phospholipid Transfer Proteins; Phospholipids; Phosphorus; Phosphorylation; Photoperiod; Photosynthesis; Phylogeny; Physical Endurance; Physicians; Pilot Projects; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plaque, Atherosclerotic; Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus

2016
Antiretroviral treatment and its impact on oral health outcomes in 5 to 7 year old Ugandan children: A 6 year follow-up visit from the ANRS 12174 randomized trial.
    Medicine, 2020, Sep-25, Volume: 99, Issue:39

    Topics: Anti-HIV Agents; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Case-Control Studies; Child; Child, Preschool; Dental Caries; Drug Therapy, Combination; Female; Gingivitis; HIV Infections; HIV-1; Humans; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Male; Oral Health; Outcome Assessment, Health Care; Prevalence; Quality of Life; Ritonavir; Tooth Eruption; Uganda

2020
Pharmacokinetics and Safety of Zidovudine, Lamivudine, and Lopinavir/Ritonavir in HIV-infected Children With Severe Acute Malnutrition in Sub-Saharan Africa: IMPAACT Protocol P1092.
    The Pediatric infectious disease journal, 2021, 05-01, Volume: 40, Issue:5

    Topics: Africa South of the Sahara; Anti-HIV Agents; Area Under Curve; Child, Preschool; Chromatography, Liquid; Cohort Studies; Drug Combinations; Drug Elimination Routes; Drug-Related Side Effects and Adverse Reactions; Female; HIV Infections; Humans; Infant; Lamivudine; Lopinavir; Male; Patient Safety; Ritonavir; Severe Acute Malnutrition; Tandem Mass Spectrometry; Zidovudine

2021
Growth, clinical and neurodevelopmental outcomes at school age are similar for children who received 1-year lamivudine or lopinavir/ritonavir HIV prophylaxis in early life.
    Scientific reports, 2021, 02-04, Volume: 11, Issue:1

    Topics: Anti-HIV Agents; Burkina Faso; Chemoprevention; Child; Child Development; Child, Preschool; Female; Follow-Up Studies; HIV Infections; Humans; Infant; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Male; Neuropsychological Tests; Ritonavir; South Africa; Surveys and Questionnaires; Uganda; Zambia

2021
Impact of postpartum tenofovir-based antiretroviral therapy on bone mineral density in breastfeeding women with HIV enrolled in a randomized clinical trial.
    PloS one, 2021, Volume: 16, Issue:2

    Topics: Absorptiometry, Photon; Adult; Anti-HIV Agents; Bone Density; Breast Feeding; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; Humans; Lopinavir; Postpartum Period; Ritonavir; Tenofovir; Young Adult

2021
Vitamin D status and associated factors among HIV-infected children and adolescents on antiretroviral therapy in Kampala, Uganda.
    PloS one, 2021, Volume: 16, Issue:6

    Topics: Calcifediol; Child; Child, Preschool; Female; HIV Infections; HIV-1; Humans; Infant; Lopinavir; Male; Ritonavir; Uganda; Vitamin D Deficiency

2021
Safety and Pharmacokinetics of Double-Dose Lopinavir/Ritonavir + Rifampin Versus Lopinavir/Ritonavir + Daily Rifabutin for Treatment of Human Immunodeficiency Virus-Tuberculosis Coinfection.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021, 08-16, Volume: 73, Issue:4

    Topics: Adult; Anti-HIV Agents; Coinfection; Drug Therapy, Combination; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Rifabutin; Rifampin; Ritonavir; Tuberculosis

2021
Understanding the acceptability and adherence to paediatric antiretroviral treatment in the new formulation of pellets (LPV/r): the protocol of a realist evaluation.
    BMJ open, 2017, 03-29, Volume: 7, Issue:3

    Topics: Administration, Oral; Anti-HIV Agents; Caregivers; Child; Culture; Data Collection; Delivery of Health Care; Drug Combinations; HIV Infections; Humans; Kenya; Lopinavir; Medication Adherence; Patient Satisfaction; Ritonavir; Socioeconomic Factors; Tablets

2017
Randomized controlled trial of the tolerability and completion of maraviroc compared with Kaletra® in combination with Truvada® for HIV post-exposure prophylaxis (MiPEP Trial).
    The Journal of antimicrobial chemotherapy, 2017, 06-01, Volume: 72, Issue:6

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Cyclohexanes; Drug Combinations; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Maraviroc; Medication Adherence; Post-Exposure Prophylaxis; Ritonavir; Triazoles; Young Adult

2017
Switching to Efavirenz Versus Remaining on Ritonavir-boosted Lopinavir in Human Immunodeficiency Virus-infected Children Exposed to Nevirapine: Long-term Outcomes of a Randomized Trial.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017, Aug-01, Volume: 65, Issue:3

    Topics: Alkynes; Anti-HIV Agents; Benzoxazines; CD4 Lymphocyte Count; Child, Preschool; Cyclopropanes; Female; HIV Infections; HIV-1; Humans; Infant; Lipids; Lopinavir; Male; Nevirapine; Ritonavir; RNA, Viral; Treatment Outcome

2017
Efavirenz-based simplification after successful early lopinavir-boosted-ritonavir-based therapy in HIV-infected children in Burkina Faso and Côte d'Ivoire: the MONOD ANRS 12206 non-inferiority randomised trial.
    BMC medicine, 2017, 04-24, Volume: 15, Issue:1

    Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Burkina Faso; Child, Preschool; Cote d'Ivoire; Cyclopropanes; Dideoxynucleosides; Drug Combinations; Drug Therapy, Combination; Female; Genotype; HIV Infections; HIV-1; Humans; Infant; Infant, Newborn; Lamivudine; Lopinavir; Male; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Outcome; Viral Load

2017
Nucleoside reverse-transcriptase inhibitor cross-resistance and outcomes from second-line antiretroviral therapy in the public health approach: an observational analysis within the randomised, open-label, EARNEST trial.
    The lancet. HIV, 2017, Volume: 4, Issue:8

    Topics: Adolescent; Adult; Africa South of the Sahara; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Male; Public Health; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Outcome; Viral Load; Young Adult

2017
Absence of neurocognitive disadvantage associated with paediatric HIV subtype A infection in children on antiretroviral therapy.
    Journal of the International AIDS Society, 2017, Volume: 20, Issue:2

    Topics: Anti-HIV Agents; CD4 Lymphocyte Count; Child; Child, Preschool; Female; HIV; HIV Infections; Humans; Leukocytes, Mononuclear; Lopinavir; Male; Neurocognitive Disorders; Reverse Transcriptase Inhibitors; Uganda

2017
A Phase II/III Trial of Lopinavir/Ritonavir Dosed According to the WHO Pediatric Weight Band Dosing Guidelines.
    The Pediatric infectious disease journal, 2018, Volume: 37, Issue:2

    Topics: Area Under Curve; Body Weight; Child; Child, Preschool; Female; HIV Infections; HIV Protease Inhibitors; Humans; Infant; Lopinavir; Male; Pharmacogenomic Testing; Practice Guidelines as Topic; Ritonavir; Viral Load; World Health Organization

2018
Tenofovir disoproxil fumarate/emtricitabine plus ritonavir-boosted lopinavir or cobicistat-boosted elvitegravir as a single-tablet regimen for HIV post-exposure prophylaxis.
    The Journal of antimicrobial chemotherapy, 2017, 10-01, Volume: 72, Issue:10

    Topics: Adult; Anti-HIV Agents; Cobicistat; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Medication Adherence; Post-Exposure Prophylaxis; Prospective Studies; Quinolones; Reverse Transcriptase Inhibitors; Ritonavir; Tablets; Tenofovir

2017
Lopinavir plus nucleoside reverse-transcriptase inhibitors, lopinavir plus raltegravir, or lopinavir monotherapy for second-line treatment of HIV (EARNEST): 144-week follow-up results from a randomised controlled trial.
    The Lancet. Infectious diseases, 2018, Volume: 18, Issue:1

    Topics: Adolescent; Adult; Africa South of the Sahara; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Child; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Outcome; Viral Load; Young Adult

2018
Estradiol Levels Are Altered in Human Immunodeficiency Virus-Infected Pregnant Women Randomized to Efavirenz-Versus Lopinavir/Ritonavir-Based Antiretroviral Therapy.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018, 01-18, Volume: 66, Issue:3

    Topics: Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Drug Combinations; Enzyme-Linked Immunosorbent Assay; Estradiol; Female; HIV Infections; HIV-1; Humans; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Progesterone; Ritonavir; Uganda

2018
Relationship between untimed plasma lopinavir concentrations and virological outcome on second-line antiretroviral therapy.
    AIDS (London, England), 2018, 01-28, Volume: 32, Issue:3

    Topics: Antiretroviral Therapy, Highly Active; Chromatography, High Pressure Liquid; Developing Countries; Drug Monitoring; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Plasma; Retrospective Studies; Treatment Outcome

2018
Week 96 efficacy of lopinavir/ritonavir monotherapy in virologically suppressed patients with HIV: a randomized non-inferiority trial (ANRS 140 DREAM).
    The Journal of antimicrobial chemotherapy, 2018, 06-01, Volume: 73, Issue:6

    Topics: Adult; Anti-Retroviral Agents; Female; France; HIV Infections; HIV-1; Hospitals, University; Humans; Lopinavir; Male; Middle Aged; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Viral Load

2018
Decreased bone turnover in HIV-infected children on antiretroviral therapy.
    Archives of osteoporosis, 2018, Apr-05, Volume: 13, Issue:1

    Topics: Absorptiometry, Photon; Alkynes; Benzoxazines; Bone Density; Bone Remodeling; Child; Child, Preschool; Collagen Type I; Cross-Sectional Studies; Cyclopropanes; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Peptides; Ritonavir; South Africa

2018
Raltegravir versus lopinavir/ritonavir for treatment of HIV-infected late-presenting pregnant women.
    HIV clinical trials, 2018, Volume: 19, Issue:3

    Topics: Adolescent; Adult; Anti-HIV Agents; Brazil; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Female; HIV Infections; HIV-1; Humans; Infectious Disease Transmission, Vertical; Lopinavir; Pilot Projects; Pregnancy; Pregnancy Complications, Infectious; Raltegravir Potassium; Ritonavir; RNA, Viral; Sustained Virologic Response; Treatment Outcome; Viral Load; Young Adult

2018
Impact of intensification with raltegravir on HIV-1-infected individuals receiving monotherapy with boosted PIs.
    The Journal of antimicrobial chemotherapy, 2018, 07-01, Volume: 73, Issue:7

    Topics: Adult; Antiretroviral Therapy, Highly Active; Darunavir; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Immunity, Cellular; Inflammation; Lopinavir; Lymphocyte Activation; Male; Middle Aged; Pilot Projects; Proof of Concept Study; Raltegravir Potassium; RNA, Viral; Viremia; Virus Replication

2018
High quality of life, treatment tolerability, safety and efficacy in HIV patients switching from triple therapy to lopinavir/ritonavir monotherapy: A randomized clinical trial.
    PloS one, 2018, Volume: 13, Issue:4

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Quality of Life; Reproducibility of Results; Ritonavir; Spain; Surveys and Questionnaires; Treatment Outcome; Viral Load

2018
Ultrasensitive Human Immunodeficiency Virus Type 1 Viral Load as a Marker of Treatment Choice for Simplification Strategies.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018, 11-28, Volume: 67, Issue:12

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Darunavir; Data Interpretation, Statistical; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Ritonavir; RNA, Viral; Treatment Failure; Viral Load

2018
Evolution of Protease Inhibitor Resistance in Human Immunodeficiency Virus Type 1 Infected Patients Failing Protease Inhibitor Monotherapy as Second-line Therapy in Low-income Countries: An Observational Analysis Within the EARNEST Randomized Trial.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019, 03-19, Volume: 68, Issue:7

    Topics: Adult; Africa; Developing Countries; Drug Resistance, Viral; Female; Genotyping Techniques; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Randomized Controlled Trials as Topic; Treatment Failure

2019
Pharmacokinetic Interactions between the Hepatitis C Virus Inhibitors Elbasvir and Grazoprevir and HIV Protease Inhibitors Ritonavir, Atazanavir, Lopinavir, and Darunavir in Healthy Volunteers.
    Antimicrobial agents and chemotherapy, 2019, Volume: 63, Issue:4

    Topics: Adult; Amides; Antiviral Agents; Atazanavir Sulfate; Benzofurans; Carbamates; Cyclopropanes; Darunavir; Drug Interactions; Female; Healthy Volunteers; Hepacivirus; Hepatitis C; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Lopinavir; Male; Middle Aged; Quinoxalines; Ritonavir; Sulfonamides; Viral Nonstructural Proteins; Young Adult

2019
Growth in HIV-1-exposed but uninfected infants treated with lopinavir-ritonavir versus lamivudine: a secondary analysis of the ANRS 12174 trial.
    The lancet. HIV, 2019, Volume: 6, Issue:5

    Topics: Adult; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Male; Ritonavir; Treatment Outcome; Viral Load; Young Adult

2019
Low-dose ritonavir-boosted darunavir once daily versus ritonavir-boosted lopinavir for participants with less than 50 HIV RNA copies per mL (WRHI 052): a randomised, open-label, phase 3, non-inferiority trial.
    The lancet. HIV, 2019, Volume: 6, Issue:7

    Topics: Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Darunavir; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Ritonavir; Treatment Outcome; Viral Load

2019
Third-line antiretroviral therapy in low-income and middle-income countries (ACTG A5288): a prospective strategy study.
    The lancet. HIV, 2019, Volume: 6, Issue:9

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Cohort Studies; Darunavir; Developing Countries; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Nitriles; Prospective Studies; Pyridazines; Pyrimidines; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Viral Load

2019
Model-based evaluation of the pharmacokinetic differences between adults and children for lopinavir and ritonavir in combination with rifampicin.
    British journal of clinical pharmacology, 2013, Volume: 76, Issue:5

    Topics: Adult; Age Factors; Anti-HIV Agents; Antitubercular Agents; Biological Availability; Child, Preschool; Cohort Studies; Drug Interactions; Female; Half-Life; HIV Infections; Humans; Infant; Lopinavir; Male; Middle Aged; Models, Biological; Nonlinear Dynamics; Rifampin; Ritonavir; Tuberculosis

2013
Steady-state pharmacokinetics of etravirine and lopinavir/ritonavir melt extrusion formulation, alone and in combination, in healthy HIV-negative volunteers.
    Journal of clinical pharmacology, 2013, Volume: 53, Issue:2

    Topics: Adult; Anti-HIV Agents; Cross-Over Studies; Drug Interactions; Drug Therapy, Combination; Female; Gels; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Nitriles; Pyridazines; Pyrimidines; Ritonavir; Young Adult

2013
Effects of once-daily darunavir/ritonavir versus lopinavir/ritonavir on metabolic parameters in treatment-naive HIV-1-infected patients at week 96: ARTEMIS.
    International journal of STD & AIDS, 2013, Volume: 24, Issue:1

    Topics: Adult; CD4 Lymphocyte Count; Darunavir; Drug Administration Schedule; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Ritonavir; RNA, Viral; Sulfonamides; Treatment Outcome; Viral Load

2013
Co-administration of a commonly used Zimbabwean herbal treatment (African potato) does not alter the pharmacokinetics of lopinavir/ritonavir.
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2013, Volume: 17, Issue:10

    Topics: Adult; Alkynes; Anti-HIV Agents; Area Under Curve; Cross-Over Studies; Drug Therapy, Combination; Female; Glucosides; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Plant Extracts; Ritonavir; Solanum tuberosum; Young Adult

2013
Lopinavir/ritonavir monotherapy as a nucleoside analogue-sparing strategy to prevent HIV-1 mother-to-child transmission: the ANRS 135 PRIMEVA phase 2/3 randomized trial.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2013, Volume: 57, Issue:6

    Topics: Adolescent; Adult; Anti-HIV Agents; Female; HIV Infections; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Lopinavir; Male; Pregnancy; Pregnancy Complications, Infectious; Ritonavir

2013
Ritonavir-boosted lopinavir plus nucleoside or nucleotide reverse transcriptase inhibitors versus ritonavir-boosted lopinavir plus raltegravir for treatment of HIV-1 infection in adults with virological failure of a standard first-line ART regimen (SECOND
    Lancet (London, England), 2013, Jun-15, Volume: 381, Issue:9883

    Topics: Adult; Anti-HIV Agents; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Nucleosides; Nucleotides; Pyrrolidinones; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Outcome

2013
Three distinct phases of HIV-1 RNA decay in treatment-naive patients receiving raltegravir-based antiretroviral therapy: ACTG A5248.
    The Journal of infectious diseases, 2013, Volume: 208, Issue:6

    Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Organophosphonates; Pilot Projects; Prospective Studies; Pyrrolidinones; Raltegravir Potassium; Ritonavir; RNA Stability; RNA, Viral; Tenofovir; Viral Load

2013
Bone mineral density in HIV participants randomized to raltegravir and lopinavir/ritonavir compared with standard second line therapy.
    AIDS (London, England), 2013, Sep-24, Volume: 27, Issue:15

    Topics: Absorptiometry, Photon; Adult; Argentina; Bone Density; Bone Diseases, Metabolic; Female; Femur; HIV Infections; HIV Protease Inhibitors; Humans; India; Lopinavir; Lumbar Vertebrae; Malaysia; Male; Osteoporosis; Prevalence; Pyrrolidinones; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Risk Factors; Ritonavir; South Africa; Thailand; Treatment Outcome

2013
WHO option B+: early experience of antiretroviral therapy sequencing after cessation of breastfeeding and risk of dermatologic toxicity.
    Journal of acquired immune deficiency syndromes (1999), 2013, Mar-01, Volume: 62, Issue:3

    Topics: Adult; Alkynes; Anti-Retroviral Agents; Benzoxazines; Breast Feeding; CD4 Lymphocyte Count; Cohort Studies; Cyclopropanes; Dideoxynucleosides; Drug Eruptions; Drug Substitution; Female; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Lopinavir; Nevirapine; Pregnancy; Pregnancy Complications, Infectious; Protease Inhibitors; Ritonavir; Uganda; World Health Organization

2013
Pharmacokinetics of rifabutin in Japanese HIV-infected patients with or without antiretroviral therapy.
    PloS one, 2013, Volume: 8, Issue:8

    Topics: Adult; Drug Administration Schedule; Drug Interactions; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Rifabutin; Ritonavir; Young Adult

2013
Switching tenofovir/emtricitabine plus lopinavir/r to raltegravir plus Darunavir/r in patients with suppressed viral load did not result in improvement of renal function but could sustain viral suppression: a randomized multicenter trial.
    PloS one, 2013, Volume: 8, Issue:8

    Topics: Adenine; Adult; Anti-HIV Agents; Darunavir; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Kidney; Kidney Function Tests; Lopinavir; Male; Middle Aged; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Sulfonamides; Tenofovir; Viral Load

2013
Pharmacokinetics of lopinavir/ritonavir and efavirenz in food insecure HIV-infected pregnant and breastfeeding women in Tororo, Uganda.
    Journal of clinical pharmacology, 2014, Volume: 54, Issue:2

    Topics: Adolescent; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Biological Availability; Breast Feeding; Cyclopropanes; Dried Blood Spot Testing; Drug Combinations; Drug Therapy, Combination; Female; Hair; HIV Infections; Humans; Lopinavir; Malnutrition; Medication Adherence; Middle Aged; Nutritional Status; Postpartum Period; Pregnancy; Pregnancy Complications, Infectious; Ritonavir; Uganda; Young Adult

2014
Hair and plasma data show that lopinavir, ritonavir, and efavirenz all transfer from mother to infant in utero, but only efavirenz transfers via breastfeeding.
    Journal of acquired immune deficiency syndromes (1999), 2013, Aug-15, Volume: 63, Issue:5

    Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Female; Hair; HIV Infections; Humans; Infant; Infant, Newborn; Lopinavir; Milk, Human; Plasma; Pregnancy; Pregnancy Complications, Infectious; Ritonavir; Uganda

2013
A randomized controlled trial to assess safety, tolerability, and antepartum viral load with increased lopinavir/ritonavir dosage in pregnancy.
    AIDS patient care and STDs, 2013, Volume: 27, Issue:11

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; HIV Infections; HIV-1; Humans; Infectious Disease Transmission, Vertical; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimesters; Prenatal Care; Protease Inhibitors; Ritonavir; RNA, Viral; Treatment Outcome; Viral Load

2013
HIV lipodystrophy in participants randomised to lopinavir/ritonavir (LPV/r) +2-3 nucleoside/nucleotide reverse transcriptase inhibitors (N(t)RTI) or LPV/r + raltegravir as second-line antiretroviral therapy.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Adult; Anti-HIV Agents; Body Fat Distribution; Body Mass Index; Cardiovascular Diseases; Cholesterol; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lipodystrophy; Logistic Models; Lopinavir; Male; Metabolic Syndrome; Middle Aged; Pyrrolidinones; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Risk Factors; Ritonavir; RNA, Viral; Viral Load; Virus Replication

2013
A simplified combination antiretroviral therapy regimen enhances adherence, treatment satisfaction and quality of life: results of a randomized clinical trial.
    HIV medicine, 2014, Volume: 15, Issue:5

    Topics: Adult; Antiretroviral Therapy, Highly Active; Belgium; Dideoxynucleosides; Drug Therapy, Combination; Female; HIV Infections; Humans; Lamivudine; Lopinavir; Male; Medication Adherence; Middle Aged; Netherlands; Odds Ratio; Patient Satisfaction; Quality of Life; Ritonavir; Zidovudine

2014
Virologic and immunologic outcomes of HIV-infected Ugandan children randomized to lopinavir/ritonavir or nonnucleoside reverse transcriptase inhibitor therapy.
    Journal of acquired immune deficiency syndromes (1999), 2014, Apr-15, Volume: 65, Issue:5

    Topics: Anti-HIV Agents; CD4 Lymphocyte Count; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Female; HIV Infections; Humans; Infant; Lopinavir; Malaria; Male; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Treatment Outcome; Uganda; Viral Load

2014
Immunological function restoration with lopinavir/ritonavir versus efavirenz containing regimens in HIV-infected patients: a randomized clinical trial.
    AIDS research and human retroviruses, 2014, Volume: 30, Issue:5

    Topics: Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; HIV Infections; Humans; Immune System; Lopinavir; Male; Middle Aged; Ritonavir; Time Factors; Treatment Outcome

2014
Renal events among women treated with tenofovir/emtricitabine in combination with either lopinavir/ritonavir or nevirapine.
    AIDS (London, England), 2014, May-15, Volume: 28, Issue:8

    Topics: Adenine; Adult; Antiviral Agents; Creatinine; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Kidney Diseases; Lopinavir; Nevirapine; Organophosphonates; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome

2014
HIV-1 genital shedding in HIV-infected patients randomized to second-line lopinavir/ritonavir monotherapy versus tenofovir/lamivudine/lopinavir/ritonavir.
    Antiviral therapy, 2014, Volume: 19, Issue:6

    Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; Follow-Up Studies; Genitalia; HIV Infections; HIV-1; Humans; Lamivudine; Lopinavir; Male; Organophosphonates; Risk Factors; Ritonavir; Tenofovir; Time Factors; Treatment Outcome; Viral Load; Virus Shedding

2014
Randomised pharmacokinetic trial of rifabutin with lopinavir/ritonavir-antiretroviral therapy in patients with HIV-associated tuberculosis in Vietnam.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Adult; Antibiotics, Antitubercular; Area Under Curve; Asian People; Biological Availability; Chemical and Drug Induced Liver Injury; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Rifabutin; Ritonavir; Treatment Outcome; Tuberculosis; Vietnam

2014
Sex differences in responses to antiretroviral treatment in South African HIV-infected children on ritonavir-boosted lopinavir- and nevirapine-based treatment.
    BMC pediatrics, 2014, Feb-12, Volume: 14

    Topics: Anti-HIV Agents; Child, Preschool; Drug Therapy, Combination; Female; HIV Infections; Humans; Infant; Lopinavir; Male; Nevirapine; Ritonavir; Sex Factors; South Africa; Treatment Outcome

2014
Comparison of body composition changes between atazanavir/ritonavir and lopinavir/ritonavir each in combination with tenofovir/emtricitabine in antiretroviral-naïve patients with HIV-1 infection.
    Clinical drug investigation, 2014, Volume: 34, Issue:4

    Topics: Absorptiometry, Photon; Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; Body Composition; Deoxycytidine; Drug Combinations; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; Humans; Lopinavir; Male; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; Tenofovir; Tomography, X-Ray Computed; Young Adult

2014
Cardiovascular disease risk factors in HIV-infected women after initiation of lopinavir/ritonavir- and nevirapine-based antiretroviral therapy in Sub-Saharan Africa: A5208 (OCTANE).
    Journal of acquired immune deficiency syndromes (1999), 2014, Jun-01, Volume: 66, Issue:2

    Topics: Adenine; Adult; Africa South of the Sahara; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Blood Pressure; Body Mass Index; Cardiovascular Diseases; CD4-Positive T-Lymphocytes; Cholesterol, HDL; Cholesterol, LDL; Deoxycytidine; Emtricitabine; Endpoint Determination; Female; HIV Infections; HIV-1; Humans; Linear Models; Logistic Models; Lopinavir; Multivariate Analysis; Nevirapine; Organophosphonates; Prospective Studies; Risk Factors; Ritonavir; RNA, Viral; Tenofovir; Triglycerides

2014
Randomized clinical trial comparing the pharmacokinetics of standard- and increased-dosage lopinavir-ritonavir coformulation tablets in HIV-positive pregnant women.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:5

    Topics: Adult; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pregnancy; Ritonavir; Young Adult

2014
Lopinavir/ritonavir pharmacokinetics, efficacy, and safety in HIV and hepatitis B or C coinfected adults without symptoms of hepatic impairment.
    Therapeutic drug monitoring, 2014, Volume: 36, Issue:2

    Topics: Adult; Case-Control Studies; Chemistry, Pharmaceutical; Coinfection; Drug Combinations; Hepatitis B; Hepatitis C; HIV Infections; HIV Protease Inhibitors; Humans; Liver; Lopinavir; Male; Middle Aged; Ritonavir; Treatment Outcome; Viral Load

2014
Artemisinin-based combination therapies are efficacious and safe for treatment of uncomplicated malaria in HIV-infected Ugandan children.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014, Aug-01, Volume: 59, Issue:3

    Topics: Antimalarials; Artemisinins; Child, Preschool; Cohort Studies; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Infant; Lopinavir; Malaria; Male; Nevirapine; Parasitemia; Quinolines; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Outcome; Uganda

2014
Dual therapy with lopinavir and ritonavir plus lamivudine versus triple therapy with lopinavir and ritonavir plus two nucleoside reverse transcriptase inhibitors in antiretroviral-therapy-naive adults with HIV-1 infection: 48 week results of the randomise
    The Lancet. Infectious diseases, 2014, Volume: 14, Issue:7

    Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Reverse Transcriptase Inhibitors; Ritonavir; Young Adult

2014
Effect of antiretroviral therapy including lopinavir/ritonavir or efavirenz on etonogestrel-releasing implant pharmacokinetics in HIV-positive women.
    Journal of acquired immune deficiency syndromes (1999), 2014, Aug-01, Volume: 66, Issue:4

    Topics: Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Biological Availability; Contraceptive Agents, Female; Cyclopropanes; Desogestrel; Drug Combinations; Drug Implants; Drug Interactions; Female; HIV Infections; Humans; Lopinavir; Ritonavir; Young Adult

2014
Comparing the efficacy of efavirenz and boosted lopinavir using viremia copy-years.
    Journal of the International AIDS Society, 2014, Volume: 17

    Topics: Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Treatment Outcome; Viral Load; Viremia

2014
A 48-week study of fat molecular alterations in HIV naive patients starting tenofovir/emtricitabine with lopinavir/ritonavir or efavirenz.
    Journal of acquired immune deficiency syndromes (1999), 2014, Aug-15, Volume: 66, Issue:5

    Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Gene Expression Regulation; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Lopinavir; Organophosphonates; Ritonavir; Subcutaneous Fat; Tenofovir; Transcriptome

2014
The pharmacokinetics and acceptability of lopinavir/ritonavir minitab sprinkles, tablets, and syrups in african HIV-infected children.
    Journal of acquired immune deficiency syndromes (1999), 2014, Jun-01, Volume: 66, Issue:2

    Topics: Adolescent; Anti-HIV Agents; Area Under Curve; Biological Availability; Child; Child, Preschool; Cohort Studies; Confidence Intervals; Cross-Over Studies; Drug Compounding; Female; HIV Infections; Humans; Infant; Lopinavir; Male; Ritonavir; Tablets; Uganda; World Health Organization

2014
Predictors of suboptimal CD4 response among women achieving virologic suppression in a randomized antiretroviral treatment trial, Africa.
    BMC infectious diseases, 2014, Jun-17, Volume: 14

    Topics: Adenine; Adult; Africa; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lopinavir; Nevirapine; Organophosphonates; Ritonavir; Tenofovir; Treatment Outcome

2014
Lopinavir/ritonavir-based antiretroviral treatment (ART) versus efavirenz-based ART for the prevention of malaria among HIV-infected pregnant women.
    The Journal of infectious diseases, 2014, Dec-15, Volume: 210, Issue:12

    Topics: Adolescent; Adult; Alkynes; Anti-HIV Agents; Antimalarials; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Female; HIV Infections; Humans; Infant, Newborn; Lopinavir; Malaria; Pregnancy; Pregnancy Complications, Infectious; Ritonavir; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination; Young Adult

2014
Inflammatory, procoagulant markers and HIV residual viremia in patients receiving protease inhibitor monotherapy or triple drug therapy: a cross-sectional study.
    BMC infectious diseases, 2014, Jul-10, Volume: 14

    Topics: Adult; Biomarkers; Cross-Sectional Studies; Cytokines; Darunavir; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Inflammation; Lopinavir; Male; Middle Aged; Ritonavir; Sulfonamides; Viremia

2014
First-line antiretroviral therapy with nevirapine versus lopinavir-ritonavir based regimens in a resource-limited setting.
    AIDS (London, England), 2014, May-15, Volume: 28, Issue:8

    Topics: Adenine; Adult; CD4 Lymphocyte Count; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Nevirapine; Organophosphonates; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load; Zidovudine

2014
Risk factors for preterm birth among HIV-infected pregnant Ugandan women randomized to lopinavir/ritonavir- or efavirenz-based antiretroviral therapy.
    Journal of acquired immune deficiency syndromes (1999), 2014, Oct-01, Volume: 67, Issue:2

    Topics: Adolescent; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Female; HIV Infections; Humans; Infant, Newborn; Lopinavir; Male; Pregnancy; Premature Birth; Risk Factors; Ritonavir; Uganda; Young Adult

2014
Impact of lopinavir-ritonavir or nevirapine on bedaquiline exposures and potential implications for patients with tuberculosis-HIV coinfection.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:11

    Topics: Adult; Anti-HIV Agents; Antitubercular Agents; Coinfection; Diarylquinolines; Drug Combinations; Drug Interactions; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Mycobacterium tuberculosis; Nevirapine; Ritonavir; Tuberculosis; Young Adult

2014
Correlates of age at attainment of developmental milestones in HIV-infected infants receiving early antiretroviral therapy.
    The Pediatric infectious disease journal, 2015, Volume: 34, Issue:1

    Topics: Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Child Development; Female; Follow-Up Studies; HIV Infections; Humans; Infant; Kenya; Lopinavir; Male; Nevirapine; Ritonavir

2015
Predictors of virologic and clinical response to nevirapine versus lopinavir/ritonavir-based antiretroviral therapy in young children with and without prior nevirapine exposure for the prevention of mother-to-child HIV transmission.
    The Pediatric infectious disease journal, 2014, Volume: 33, Issue:8

    Topics: Africa South of the Sahara; Anti-HIV Agents; Child, Preschool; Female; HIV Infections; HIV-1; Humans; Incidence; India; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Lopinavir; Male; Nevirapine; Ritonavir; Treatment Outcome

2014
Increased bone resorption during tenofovir plus lopinavir/ritonavir therapy in Chinese individuals with HIV.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2015, Volume: 26, Issue:3

    Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Biomarkers; Bone Remodeling; Bone Resorption; Collagen Type I; Drug Combinations; Drug Substitution; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Peptides; Ritonavir; Tenofovir; Young Adult

2015
[Lack of bioavailability of generic lopinavir/ritonavir not prequalified by WHO marketed in Africa (Congo Brazzaville)].
    Bulletin de la Societe de pathologie exotique (1990), 2015, Volume: 108, Issue:1

    Topics: Africa; Commerce; Congo; Developing Countries; Drug Approval; Drug Combinations; Drugs, Generic; HIV Infections; HIV-1; Humans; Lopinavir; Ritonavir; Therapeutic Equivalency; World Health Organization

2015
Impact of body weight and missed doses on lopinavir concentrations with standard and increased lopinavir/ritonavir doses during late pregnancy.
    The Journal of antimicrobial chemotherapy, 2015, Volume: 70, Issue:1

    Topics: Adolescent; Adult; Anti-HIV Agents; Body Weight; Clinical Trials as Topic; Female; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Lopinavir; Monte Carlo Method; Plasma; Pregnancy; Pregnancy Complications, Infectious; Prospective Studies; Ritonavir; Thailand; Treatment Outcome; United States; Young Adult

2015
Pharmacokinetics and safety of rifabutin in young HIV-infected children receiving rifabutin and lopinavir/ritonavir.
    The Journal of antimicrobial chemotherapy, 2015, Volume: 70, Issue:2

    Topics: Antiretroviral Therapy, Highly Active; Antitubercular Agents; Area Under Curve; Child, Preschool; Coinfection; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Infant; Lopinavir; Male; Rifabutin; Ritonavir; Treatment Outcome; Tuberculosis

2015
Pharmacokinetics of sifuvirtide in treatment-naive and treatment-experienced HIV-infected patients.
    Journal of pharmaceutical sciences, 2014, Volume: 103, Issue:12

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Didanosine; Double-Blind Method; Drug Combinations; Enfuvirtide; Female; HIV Envelope Protein gp41; HIV Fusion Inhibitors; HIV Infections; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Peptide Fragments; Peptides; Ritonavir

2014
Monotherapy with lopinavir/ritonavir versus standard of care in HIV-infected patients virologically suppressed while on treatment with protease inhibitor-based regimens: results from the MoLo study.
    The new microbiologica, 2014, Volume: 37, Issue:4

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Ritonavir; Viral Load

2014
Randomized pharmacokinetic evaluation of different rifabutin doses in African HIV- infected tuberculosis patients on lopinavir/ritonavir-based antiretroviral therapy.
    BMC pharmacology & toxicology, 2014, Nov-19, Volume: 15

    Topics: Adult; Anti-HIV Agents; Antibiotics, Antitubercular; Black People; Coinfection; Cross-Over Studies; Drug Therapy, Combination; Female; HIV Infections; Humans; Isoniazid; Lamivudine; Lopinavir; Male; Neutropenia; Rifabutin; South Africa; Stavudine; Tuberculosis; Uveitis

2014
Efficacy and safety of lopinavir/ritonavir versus efavirenz-based antiretroviral therapy in HIV-infected pregnant Ugandan women.
    AIDS (London, England), 2015, Jan-14, Volume: 29, Issue:2

    Topics: Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Breast Feeding; CD4 Lymphocyte Count; Cyclopropanes; Female; HIV Infections; HIV-1; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Lopinavir; Malaria; Pregnancy; Pregnancy Complications, Infectious; Ritonavir; Uganda; Viral Load

2015
Depot medroxyprogesterone acetate in combination with a twice-daily lopinavir-ritonavir-based regimen in HIV-infected women showed effective contraception and a lack of clinically significant interactions, with good safety and tolerability: results of the
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:4

    Topics: Adolescent; Contraceptives, Oral, Synthetic; Delayed-Action Preparations; Drug Interactions; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Medroxyprogesterone Acetate; Middle Aged; Ovulation; Progesterone; Ritonavir; Young Adult

2015
Maraviroc 150 mg daily plus lopinavir/ritonavir, a nucleoside/nucleotide reverse transcriptase inhibitor-sparing regimen for HIV-infected naive patients: 48-week final results of VEMAN study.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2015, Volume: 21, Issue:5

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cyclohexanes; DNA, Viral; Drug Combinations; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Maraviroc; Prospective Studies; Ritonavir; Treatment Outcome; Triazoles; Viral Load

2015
Raltegravir non-inferior to nucleoside based regimens in second-line therapy with lopinavir/ritonavir over 96 weeks: a randomised open label study for the treatment of HIV-1 infection.
    PloS one, 2015, Volume: 10, Issue:2

    Topics: Adult; Drug Therapy, Combination; HIV Infections; HIV Integrase Inhibitors; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Raltegravir Potassium; Ritonavir; Secondary Care

2015
Week 120 efficacy of tenofovir, lamivudine and lopinavir/r-based second-line antiretroviral therapy in treatment-experienced HIV patients.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; China; Cohort Studies; Drug Resistance, Viral; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Ritonavir; Tenofovir

2015
Residual HIV-1 replication may impact immune recovery in patients on first-line lopinavir/ritonavir monotherapy.
    The Journal of antimicrobial chemotherapy, 2015, Volume: 70, Issue:9

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cross-Sectional Studies; Drug Combinations; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Ritonavir; T-Lymphocyte Subsets; Treatment Outcome; Viral Load; Virus Replication

2015
Dual treatment with lopinavir-ritonavir plus lamivudine versus triple treatment with lopinavir-ritonavir plus lamivudine or emtricitabine and a second nucleos(t)ide reverse transcriptase inhibitor for maintenance of HIV-1 viral suppression (OLE): a random
    The Lancet. Infectious diseases, 2015, Volume: 15, Issue:7

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Intention to Treat Analysis; Lamivudine; Lopinavir; Maintenance Chemotherapy; Male; Middle Aged; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Viral Load

2015
Population approach to analyze the pharmacokinetics of free and total lopinavir in HIV-infected pregnant women and consequences for dose adjustment.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:9

    Topics: Adult; Anti-HIV Agents; Female; Genotyping Techniques; HIV Infections; Humans; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Young Adult

2015
Effect of Extra Virgin Olive Oil on Biomarkers of Inflammation in HIV-Infected Patients: A Randomized, Crossover, Controlled Clinical Trial.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, Aug-16, Volume: 21

    Topics: Adolescent; Adult; Aged; Antiretroviral Therapy, Highly Active; Atherosclerosis; Biomarkers; C-Reactive Protein; Cross-Over Studies; Drug Combinations; Food Handling; HIV Infections; HIV Protease Inhibitors; Humans; Inflammation Mediators; Lopinavir; Male; Middle Aged; Olive Oil; Ritonavir; Single-Blind Method; Young Adult

2015
Peripheral neuropathy in HIV patients in sub-Saharan Africa failing first-line therapy and the response to second-line ART in the EARNEST trial.
    Journal of neurovirology, 2016, Volume: 22, Issue:1

    Topics: Adult; Africa South of the Sahara; Alcohol Abstinence; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Antitubercular Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Drug Combinations; Female; HIV Infections; HIV-1; Humans; Isoniazid; Logistic Models; Lopinavir; Male; Middle Aged; Peripheral Nervous System Diseases; Raltegravir Potassium; Ritonavir; RNA, Viral; Smoking; Tuberculosis, Pulmonary; Viral Load

2016
Evidence for Reduced Drug Susceptibility without Emergence of Major Protease Mutations following Protease Inhibitor Monotherapy Failure in the SARA Trial.
    PloS one, 2015, Volume: 10, Issue:9

    Topics: Drug Resistance, Viral; gag Gene Products, Human Immunodeficiency Virus; Genotype; HIV Infections; HIV Protease; HIV Protease Inhibitors; Humans; Lopinavir; Mutation; Phenotype; Ritonavir; Treatment Failure

2015
Baseline HIV-1 resistance, virological outcomes, and emergent resistance in the SECOND-LINE trial: an exploratory analysis.
    The lancet. HIV, 2015, Volume: 2, Issue:2

    Topics: Adult; Anti-HIV Agents; Dideoxynucleosides; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lamivudine; Lopinavir; Male; Medication Adherence; Middle Aged; Ritonavir; South Australia; Tenofovir; Treatment Outcome; Viral Load; Young Adult

2015
The pharmacokinetics of lopinavir/ritonavir when given with isoniazid in South African HIV-infected individuals.
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2015, Volume: 19, Issue:10

    Topics: Adult; Anti-HIV Agents; Antitubercular Agents; Area Under Curve; Biological Availability; Disease Progression; Drug Combinations; Drug Interactions; Female; HIV Infections; Humans; Isoniazid; Latent Tuberculosis; Lopinavir; Male; Ritonavir; South Africa

2015
Contribution of different antiretroviral regimens containing zidovudine, lamivudine and ritonavir-boosted lopinavir on HIV viral load reduction during pregnancy.
    Antiviral therapy, 2016, Volume: 21, Issue:5

    Topics: Adult; Anti-HIV Agents; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Ritonavir; Thailand; Viral Load; Zidovudine

2016
No Need for Lopinavir Dose Adjustment during Pregnancy: a Population Pharmacokinetic and Exposure-Response Analysis in Pregnant and Nonpregnant HIV-Infected Subjects.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:1

    Topics: Adult; Anti-HIV Agents; Area Under Curve; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lopinavir; Pregnancy; Pregnancy Trimester, Third; Ritonavir; Tablets; Tandem Mass Spectrometry; Viral Load

2016
Efavirenz-Based Antiretroviral Therapy Among Nevirapine-Exposed HIV-Infected Children in South Africa: A Randomized Clinical Trial.
    JAMA, 2015, Nov-03, Volume: 314, Issue:17

    Topics: Alkynes; Anti-Retroviral Agents; Benzoxazines; Child; Child, Preschool; Cyclopropanes; Drug Therapy, Combination; Female; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Lopinavir; Male; Nevirapine; South Africa; Viral Load

2015
Once vs. twice-daily lopinavir/ritonavir in HIV-1-infected children.
    AIDS (London, England), 2015, Nov-28, Volume: 29, Issue:18

    Topics: Adolescent; Anti-HIV Agents; Child; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Ritonavir; Treatment Outcome; Viral Load

2015
Neurocognitive Function at the First-Line Failure and on the Second-Line Antiretroviral Therapy in Africa: Analyses From the EARNEST Trial.
    Journal of acquired immune deficiency syndromes (1999), 2016, Apr-15, Volume: 71, Issue:5

    Topics: Adult; Africa South of the Sahara; Anti-HIV Agents; CD4 Lymphocyte Count; Cognition; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Neurocognitive Disorders; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Ritonavir; Viral Load

2016
Extended pre-exposure prophylaxis with lopinavir-ritonavir versus lamivudine to prevent HIV-1 transmission through breastfeeding up to 50 weeks in infants in Africa (ANRS 12174): a randomised controlled trial.
    Lancet (London, England), 2016, Feb-06, Volume: 387, Issue:10018

    Topics: Africa South of the Sahara; Anti-HIV Agents; Breast Feeding; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Pre-Exposure Prophylaxis; Ritonavir

2016
Tipranavir/Ritonavir (500/200 mg and 500/100 mg) Was Virologically Non-Inferior to Lopinavir/Ritonavir (400/100 mg) at Week 48 in Treatment-Naïve HIV-1-Infected Patients: A Randomized, Multinational, Multicenter Trial.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Chemical and Drug Induced Liver Injury; Disease Progression; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; Gastrointestinal Diseases; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Proportional Hazards Models; Pyridines; Pyrones; Ritonavir; Sulfonamides; Tenofovir; Young Adult

2016
Short Communication: Efficacy and Safety of Treatment Simplification to Lopinavir/Ritonavir or Darunavir/Ritonavir Monotherapy: A Randomized Clinical Trial.
    AIDS research and human retroviruses, 2016, Volume: 32, Issue:5

    Topics: Adult; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cerebrospinal Fluid; Darunavir; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Prospective Studies; Ritonavir; Semen; Viral Load; Young Adult

2016
The interaction between artemether-lumefantrine and lopinavir/ritonavir-based antiretroviral therapy in HIV-1 infected patients.
    BMC infectious diseases, 2016, Jan-27, Volume: 16

    Topics: Adult; Anti-HIV Agents; Artemether; Artemisinins; Drug Interactions; Ethanolamines; Female; Fluorenes; HIV Infections; HIV-1; Humans; Lopinavir; Lumefantrine; Male; Ritonavir

2016
Contribution of Gag and Protease to HIV-1 Phenotypic Drug Resistance in Pediatric Patients Failing Protease Inhibitor-Based Therapy.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:4

    Topics: Amino Acid Substitution; Child, Preschool; Drug Resistance, Viral; Female; Gene Expression; Gene Products, gag; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Infant; Lopinavir; Male; Mutagenesis, Site-Directed; Mutation; Phenotype; Ritonavir; Treatment Failure

2016
Combination of long-acting HIV fusion inhibitor albuvirtide and LPV/r showed potent efficacy in HIV-1 patients.
    AIDS research and therapy, 2016, Volume: 13

    Topics: Adolescent; Adult; Drug Interactions; Drug Therapy, Combination; Female; HIV Fusion Inhibitors; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Maleimides; Middle Aged; Peptides; Ritonavir; Treatment Outcome; Young Adult

2016
Nucleoside-Sparing Regimens With Raltegravir and a Boosted Protease Inhibitor: An Unsettled Issue.
    Journal of acquired immune deficiency syndromes (1999), 2016, 06-01, Volume: 72, Issue:2

    Topics: Adult; Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Dose-Response Relationship, Drug; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Raltegravir Potassium; Ritonavir; RNA, Viral; Surveys and Questionnaires; Tenofovir; Treatment Outcome

2016
High Variability of Hormonal Levels and No Clinically Relevant Interaction Between Ethinyl Estradiol, Desogestrel and Lopinavir/Ritonavir in a Small Sample of HIV-positive Adolescents.
    Journal of acquired immune deficiency syndromes (1999), 2016, Aug-15, Volume: 72, Issue:5

    Topics: Adolescent; Anti-HIV Agents; Contraceptive Agents, Female; Desogestrel; Drug Combinations; Drug Interactions; Ethinyl Estradiol; HIV Infections; Humans; Lopinavir; Pilot Projects; Prospective Studies; Ritonavir; Treatment Outcome

2016
Improvement of lipoatrophy by switching from efavirenz to lopinavir/ritonavir.
    HIV medicine, 2016, Volume: 17, Issue:5

    Topics: Adipogenesis; Adipose Tissue; Alkynes; Anti-Retroviral Agents; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Drug Combinations; Extremities; Female; Gene Expression Regulation; HIV Infections; Humans; Lipid Metabolism; Lipids; Lopinavir; Male; Middle Aged; Pilot Projects; Ritonavir; Treatment Outcome

2016
Improvement of BMD after Switching from Lopinavir/R Plus Two Nucleos(T)ide Reverse Transcriptase Inhibitors to Lopinavir/R Plus Lamivudine: OLE-LIP Substudy.
    HIV clinical trials, 2016, Volume: 17, Issue:3

    Topics: Adult; Antiretroviral Therapy, Highly Active; Bone Density; Bone Diseases; CD4 Lymphocyte Count; Drug Substitution; Female; HIV Infections; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Reverse Transcriptase Inhibitors; Risk Factors; Viral Load

2016
Acceptability of lopinavir/r pellets (minitabs), tablets and syrups in HIV-infected children.
    Antiviral therapy, 2016, Volume: 21, Issue:7

    Topics: Anti-HIV Agents; Child; Child, Preschool; Cross-Over Studies; HIV Infections; Humans; Infant; Lopinavir; Patient Acceptance of Health Care; Tablets; Taste; Viral Load

2016
Bleeding patterns of HIV-infected women using an etonogestrel-releasing contraceptive implant and efavirenz-based or lopinavir/ritonavir-based antiretroviral therapy.
    The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception, 2016, Volume: 21, Issue:4

    Topics: Adolescent; Adult; Alkynes; Amenorrhea; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Desogestrel; Drug Combinations; Drug Implants; Drug Interactions; Female; HIV Infections; Humans; Lamivudine; Lopinavir; Metrorrhagia; Prospective Studies; Ritonavir; Young Adult; Zidovudine

2016
Raltegravir in second-line antiretroviral therapy in resource-limited settings (SELECT): a randomised, phase 3, non-inferiority study.
    The lancet. HIV, 2016, Volume: 3, Issue:6

    Topics: Adult; Africa South of the Sahara; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Brazil; CD4 Lymphocyte Count; Drug Resistance, Viral; Health Resources; Health Services Accessibility; HIV Infections; HIV-1; Humans; India; Lopinavir; Malawi; Male; Medically Underserved Area; Peru; Raltegravir Potassium; Reverse Transcriptase Inhibitors; RNA, Viral; Thailand; Viral Load

2016
Switching Lopinavir/Ritonavir to Atazanavir/Ritonavir vs Adding Atorvastatin in HIV-Infected Patients Receiving Second-Line Antiretroviral Therapy With Hypercholesterolemia: A Randomized Controlled Trial.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016, 09-15, Volume: 63, Issue:6

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Atorvastatin; Cholesterol; Female; HIV Infections; Humans; Hypercholesterolemia; Lipoproteins, LDL; Lopinavir; Male; Middle Aged; Ritonavir

2016
Efavirenz is associated with higher bone mass in South African children with HIV.
    AIDS (London, England), 2016, 10-23, Volume: 30, Issue:16

    Topics: Absorptiometry, Photon; Alkynes; Anti-Retroviral Agents; Benzoxazines; Bone and Bones; Bone Development; CD4 Lymphocyte Count; Child; Cross-Sectional Studies; Cyclopropanes; Female; HIV Infections; Humans; Lopinavir; Male; Ritonavir; South Africa; Treatment Outcome; Viral Load

2016
Nevirapine- Versus Lopinavir/Ritonavir-Based Antiretroviral Therapy in HIV-Infected Infants and Young Children: Long-term Follow-up of the IMPAACT P1060 Randomized Trial.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016, 10-15, Volume: 63, Issue:8

    Topics: Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Child, Preschool; Female; Follow-Up Studies; HIV Infections; Humans; Infant; Kaplan-Meier Estimate; Lopinavir; Male; Nevirapine; Ritonavir; Severity of Illness Index; Treatment Failure; Treatment Outcome; Viral Load

2016
Monotherapy with darunavir/ritonavir or lopinavir/ritonavir versus standard antiretroviral therapy: a randomized clinical trial (2pm Study).
    The new microbiologica, 2016, Volume: 39, Issue:4

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Darunavir; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Ritonavir

2016
Dyslipidemias and Elevated Cardiovascular Risk on Lopinavir-Based Antiretroviral Therapy in Cambodia.
    PloS one, 2016, Volume: 11, Issue:8

    Topics: Adult; Cambodia; Cardiovascular Diseases; Cross-Sectional Studies; Dyslipidemias; Female; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lipoproteins, LDL; Lopinavir; Male; Middle Aged

2016
Growth Recovery Among HIV-infected Children Randomized to Lopinavir/Ritonavir or NNRTI-based Antiretroviral Therapy.
    The Pediatric infectious disease journal, 2016, Volume: 35, Issue:12

    Topics: Anti-Retroviral Agents; Body Height; Body Weight; Child, Preschool; Female; HIV Infections; Humans; Infant; Infant, Newborn; Lopinavir; Male; Ritonavir

2016
Therapeutic Drug Monitoring of Lopinavir in HIV-Infected Children on Second-Line Antiretroviral Therapy in Asia.
    Therapeutic drug monitoring, 2016, Volume: 38, Issue:6

    Topics: Adolescent; Anti-Retroviral Agents; Asia; Child; Drug Monitoring; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Viral Load

2016
Body composition and metabolic outcomes after 96 weeks of treatment with ritonavir-boosted lopinavir plus either nucleoside or nucleotide reverse transcriptase inhibitors or raltegravir in patients with HIV with virological failure of a standard first-lin
    The lancet. HIV, 2017, Volume: 4, Issue:1

    Topics: Absorptiometry, Photon; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Body Composition; CD4 Lymphocyte Count; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; HIV-Associated Lipodystrophy Syndrome; Humans; International Cooperation; Lamivudine; Lopinavir; Male; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Viral Load

2017
Costs of Care of HIV-Infected Children Initiating Lopinavir/Ritonavir-Based Antiretroviral Therapy before the Age of Two in Cote d'Ivoire.
    PloS one, 2016, Volume: 11, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Cote d'Ivoire; Female; Follow-Up Studies; Health Care Costs; HIV Infections; Humans; Infant; Lopinavir; Lost to Follow-Up; Male; Outcome Assessment, Health Care; Prospective Studies; Ritonavir; Survival Rate

2016
Malaria in HIV-Infected Children Receiving HIV Protease-Inhibitor- Compared with Non-Nucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy, IMPAACT P1068s, Substudy to P1060.
    PloS one, 2016, Volume: 11, Issue:12

    Topics: Antimalarials; CD4 Lymphocyte Count; Child; Child, Preschool; Coinfection; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Infant; Lamivudine; Lopinavir; Malaria, Falciparum; Malawi; Male; Nevirapine; Plasmodium falciparum; Reverse Transcriptase Inhibitors; Ritonavir; Viral Load; Zidovudine

2016
Cyclosporine A in addition to standard ART during primary HIV-1 infection: pilot randomized clinical trial.
    The Journal of antimicrobial chemotherapy, 2017, 03-01, Volume: 72, Issue:3

    Topics: Acute Disease; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cyclosporine; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pilot Projects; Ritonavir; Young Adult

2017
Atherogenic properties of LDL particles after switching from Truvada or Kivexa plus lopinavir/r to lamivudine plus lopinavir/r: OLE-MET substudy.
    HIV clinical trials, 2017, Volume: 18, Issue:2

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biomarkers; CD4 Lymphocyte Count; Dideoxynucleosides; Drug Combinations; Drug Substitution; Female; HIV Infections; Humans; Lamivudine; Lipid Metabolism; Lipids; Lipoproteins, LDL; Lopinavir; Male; Viral Load

2017
Does efavirenz replacement improve neurological function in treated HIV infection?
    HIV medicine, 2017, Volume: 18, Issue:9

    Topics: Adult; Alkynes; Benzoxazines; Brain Chemistry; Cognition; Cyclopropanes; Drug Therapy, Combination; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Neuropsychological Tests; Proton Magnetic Resonance Spectroscopy; Ritonavir; Treatment Outcome; Young Adult

2017
Double boosted protease inhibitors, saquinavir, and lopinavir/ritonavir, in nucleoside pretreated children at 48 weeks.
    The Pediatric infectious disease journal, 2008, Volume: 27, Issue:7

    Topics: Anti-HIV Agents; Blood Chemical Analysis; CD4 Lymphocyte Count; Child; Cholesterol; Drug Resistance, Viral; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Hyperlipidemias; Lopinavir; Male; Prospective Studies; Pyrimidinones; Ritonavir; Saquinavir; Thailand; Treatment Refusal; Triglycerides; Viral Load

2008
Lopinavir/ritonavir pharmacokinetics in HIV/HCV-coinfected patients with or without cirrhosis.
    Therapeutic drug monitoring, 2008, Volume: 30, Issue:3

    Topics: Adult; Area Under Curve; Body Weight; CD4 Lymphocyte Count; Chromatography, High Pressure Liquid; Female; Hepatitis C; HIV Infections; HIV Protease Inhibitors; Humans; Liver Cirrhosis; Liver Function Tests; Lopinavir; Male; Middle Aged; Prospective Studies; Pyrimidinones; Risk Factors; Ritonavir; Spectrophotometry, Ultraviolet; Ultrafiltration; Ultrasonography

2008
Efficacy and safety of once-daily darunavir/ritonavir versus lopinavir/ritonavir in treatment-naive HIV-1-infected patients at week 48.
    AIDS (London, England), 2008, Jul-31, Volume: 22, Issue:12

    Topics: Adult; CD4 Lymphocyte Count; Darunavir; Drug Administration Schedule; Drug Combinations; Drug Resistance, Viral; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lipids; Lopinavir; Male; Pyrimidinones; Ritonavir; RNA, Viral; Sulfonamides; Treatment Outcome; Viral Load; Weight Gain

2008
Anti-HIV agents. The Castle study: lopinavir vs. atazanavir.
    TreatmentUpdate, 2008, Volume: 20, Issue:2

    Topics: Atazanavir Sulfate; CD4 Lymphocyte Count; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Oligopeptides; Pyridines; Pyrimidinones; Viral Load

2008
Efficacy and tolerability of a fosamprenavir-ritonavir-based versus a lopinavir-ritonavir-based antiretroviral treatment in 82 therapy-naïve patients with HIV-1 infection.
    International journal of STD & AIDS, 2008, Volume: 19, Issue:8

    Topics: Adult; Anti-HIV Agents; Carbamates; Diarrhea; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; Furans; HIV Infections; HIV Protease; HIV-1; Humans; Hypertriglyceridemia; Lopinavir; Male; Middle Aged; Organophosphates; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Sulfonamides; Treatment Failure; Treatment Outcome

2008
Metabolic changes in protease inhibitor-naive patients treated for 1 year with lopinavir/ritonavir.
    Journal of acquired immune deficiency syndromes (1999), 2008, Aug-15, Volume: 48, Issue:5

    Topics: Adult; Blood Glucose; Cardiovascular Diseases; CD4 Lymphocyte Count; Cholesterol; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Insulin Resistance; Lipids; Lopinavir; Male; Pyrimidinones; Risk Factors; Ritonavir

2008
Effect of lopinavir/ritonavir monotherapy on quality of life and self-reported symptoms among antiretroviral-naive patients: results of the MONARK trial.
    Antiviral therapy, 2008, Volume: 13, Issue:4

    Topics: Anti-HIV Agents; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Pyrimidinones; Quality of Life; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Outcome; Viral Load; Zidovudine

2008
Endothelial function in human immunodeficiency virus-infected antiretroviral-naive subjects before and after starting potent antiretroviral therapy: The ACTG (AIDS Clinical Trials Group) Study 5152s.
    Journal of the American College of Cardiology, 2008, Aug-12, Volume: 52, Issue:7

    Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Brachial Artery; CD4 Lymphocyte Count; Cyclopropanes; Endothelium, Vascular; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Male; Organophosphonates; Prospective Studies; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Stavudine; Tenofovir; Time Factors; Zidovudine

2008
A king in the CASTLE? Optimum initial HIV protease inhibitor.
    Lancet (London, England), 2008, Aug-23, Volume: 372, Issue:9639

    Topics: Atazanavir Sulfate; Drug Combinations; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Oligopeptides; Pyridines; Pyrimidinones; Ritonavir; Tablets; Viral Load

2008
Once-daily atazanavir/ritonavir versus twice-daily lopinavir/ritonavir, each in combination with tenofovir and emtricitabine, for management of antiretroviral-naive HIV-1-infected patients: 48 week efficacy and safety results of the CASTLE study.
    Lancet (London, England), 2008, Aug-23, Volume: 372, Issue:9639

    Topics: Adult; Aged; Atazanavir Sulfate; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Oligopeptides; Pyridines; Pyrimidinones; Ritonavir; Viral Load

2008
Simultaneous population pharmacokinetic model for lopinavir and ritonavir in HIV-infected adults.
    Clinical pharmacokinetics, 2008, Volume: 47, Issue:10

    Topics: Adult; Cross-Sectional Studies; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Models, Biological; Pyrimidinones; Ritonavir

2008
CASTLE data show no gender differences.
    AIDS patient care and STDs, 2008, Volume: 22, Issue:9

    Topics: Anti-HIV Agents; Atazanavir Sulfate; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Oligopeptides; Pyridines; Pyrimidinones; Sex Factors; Viral Load

2008
Effects of boosted tipranavir and lopinavir on body composition, insulin sensitivity and adipocytokines in antiretroviral-naive adults.
    AIDS (London, England), 2008, Nov-12, Volume: 22, Issue:17

    Topics: Adiponectin; Adult; Body Composition; CD4 Lymphocyte Count; Drug Administration Schedule; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; HIV-Associated Lipodystrophy Syndrome; Humans; Insulin Resistance; Lopinavir; Male; Pyridines; Pyrimidinones; Pyrones; Ritonavir; Sulfonamides

2008
Early antiretroviral therapy and mortality among HIV-infected infants.
    The New England journal of medicine, 2008, Nov-20, Volume: 359, Issue:21

    Topics: Anti-HIV Agents; CD4 Lymphocyte Count; Disease Progression; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Infant; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Male; Pyrimidinones; Ritonavir; Treatment Failure; Zidovudine

2008
Steady-state pharmacokinetics of lopinavir/ritonavir in combination with efavirenz in human immunodeficiency virus-infected pediatric patients.
    The Pediatric infectious disease journal, 2009, Volume: 28, Issue:2

    Topics: Adolescent; Alkynes; Anti-HIV Agents; Benzoxazines; Child; Child, Preschool; Cyclopropanes; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; Humans; Lopinavir; Male; Pyrimidinones; Ritonavir

2009
Lopinavir/ritonavir pharmacokinetics in a substitution of high-dose soft-gelatin capsule to tablet formulation.
    Journal of clinical pharmacology, 2009, Volume: 49, Issue:2

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Capsules; Cytochrome P-450 CYP3A; Drug Combinations; Drug Therapy, Combination; Enzyme Induction; Female; Gelatin; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; Tablets

2009
Study of the gastrointestinal tolerance of a new tablet formulation of the lopinavir/ritonavir antiretroviral in HIV-infected patients.
    Journal of acquired immune deficiency syndromes (1999), 2009, Mar-01, Volume: 50, Issue:3

    Topics: Adult; Aged; Drug Combinations; Female; Gastrointestinal Tract; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Prospective Studies; Pyrimidinones; Ritonavir

2009
[Darunavir in treatment-naïve patients. The ARTEMIS study].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 10

    Topics: Adult; CD4 Lymphocyte Count; Darunavir; Drug Therapy, Combination; Dyslipidemias; Female; Gastrointestinal Diseases; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Pyrimidinones; Ritonavir; RNA, Viral; Sulfonamides; Viral Load

2008
[Darunavir as first-line therapy. The TITAN study].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 10

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Darunavir; Diarrhea; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Hyperlipidemias; Lopinavir; Male; Prognosis; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Salvage Therapy; Sulfonamides

2008
Antiviral activity and safety of aplaviroc, a CCR5 antagonist, in combination with lopinavir/ritonavir in HIV-infected, therapy-naïve patients: results of the EPIC study (CCR100136).
    HIV medicine, 2009, Volume: 10, Issue:2

    Topics: Adult; Aged; Benzoates; Diketopiperazines; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Piperazines; Pyrimidinones; Receptors, CCR5; Ritonavir; RNA, Viral; Spiro Compounds; Young Adult

2009
Influence of baseline protease inhibitor resistance on the efficacy of darunavir/ritonavir or lopinavir/ritonavir in the TITAN trial.
    Journal of acquired immune deficiency syndromes (1999), 2008, Dec-15, Volume: 49, Issue:5

    Topics: Anti-HIV Agents; Darunavir; Drug Resistance, Multiple, Viral; HIV Infections; HIV-1; Humans; Lopinavir; Mutation; Protease Inhibitors; Pyrimidinones; Ritonavir; Sulfonamides

2008
Early initiation of lopinavir/ritonavir in infants less than 6 weeks of age: pharmacokinetics and 24-week safety and efficacy.
    The Pediatric infectious disease journal, 2009, Volume: 28, Issue:3

    Topics: Area Under Curve; Drug Administration Schedule; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Infant; Lopinavir; Male; Pyrimidinones; Ritonavir; RNA, Viral; Treatment Outcome; Viral Load

2009
A once-daily lopinavir/ritonavir-based regimen is noninferior to twice-daily dosing and results in similar safety and tolerability in antiretroviral-naive subjects through 48 weeks.
    Journal of acquired immune deficiency syndromes (1999), 2009, Apr-15, Volume: 50, Issue:5

    Topics: Adult; Capsules; Drug Administration Schedule; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; Tablets

2009
A randomized, open-label study of a nucleoside analogue reverse transcriptase inhibitor-sparing regimen in antiretroviral-naive HIV-infected patients.
    Journal of acquired immune deficiency syndromes (1999), 2009, Mar-01, Volume: 50, Issue:3

    Topics: Adult; CD4 Lymphocyte Count; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Lopinavir; Male; Nevirapine; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Viral Load; Zidovudine

2009
Pilot pharmacokinetic study of human immunodeficiency virus-infected patients receiving tenofovir disoproxil fumarate (TDF): investigation of systemic and intracellular interactions between TDF and abacavir, lamivudine, or lopinavir-ritonavir.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:5

    Topics: Adenine; Adult; Anti-HIV Agents; Area Under Curve; Cross-Sectional Studies; Dideoxynucleosides; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Longitudinal Studies; Lopinavir; Male; Middle Aged; Organophosphonates; Pilot Projects; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Treatment Outcome

2009
Predictors of loss of virologic response in subjects who simplified to lopinavir/ritonavir monotherapy from lopinavir/ritonavir plus zidovudine/lamivudine.
    AIDS research and human retroviruses, 2009, Volume: 25, Issue:3

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; HIV Infections; HIV-1; Humans; Lamivudine; Lopinavir; Medication Adherence; Plasma; Pyrimidinones; Ritonavir; Time Factors; Treatment Outcome; Viral Load; Zidovudine

2009
Peripheral and visceral fat changes following a treatment switch to a non-thymidine analogue or a nucleoside-sparing regimen in HIV-infected subjects with peripheral lipoatrophy: results of ACTG A5110.
    The Journal of antimicrobial chemotherapy, 2009, Volume: 63, Issue:5

    Topics: Anti-HIV Agents; CD4 Lymphocyte Count; Dideoxynucleosides; Female; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Intra-Abdominal Fat; Lopinavir; Male; Middle Aged; Nevirapine; Pyrimidinones; Radiography, Abdominal; Stavudine; Thigh; Viral Load; Zidovudine

2009
Prognostic factors for virological response in antiretroviral therapy-naive patients in the MONARK Trial randomized to ritonavir-boosted lopinavir alone.
    Antiviral therapy, 2009, Volume: 14, Issue:1

    Topics: Adult; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Medication Adherence; Pilot Projects; Predictive Value of Tests; Prognosis; Pyrimidinones; Ritonavir; RNA, Viral; Viral Load

2009
Lopinavir-ritonavir monotherapy versus lopinavir-ritonavir and 2 nucleosides for maintenance therapy of HIV: 96-week analysis.
    Journal of acquired immune deficiency syndromes (1999), 2009, Jun-01, Volume: 51, Issue:2

    Topics: Anti-HIV Agents; Drug Resistance, Viral; Drug Therapy, Combination; HIV Infections; Humans; Lopinavir; Middle Aged; Nucleosides; Pyrimidinones; Ritonavir

2009
Efficacy and safety of switching from boosted lopinavir to boosted atazanavir in patients with virological suppression receiving a LPV/r-containing HAART: the ATAZIP study.
    Journal of acquired immune deficiency syndromes (1999), 2009, May-01, Volume: 51, Issue:1

    Topics: Adult; Alanine Transaminase; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Aspartate Aminotransferases; Atazanavir Sulfate; Drug Resistance, Viral; Drug Tolerance; Female; HIV Infections; HIV-1; Humans; Lipids; Liver; Lopinavir; Male; Middle Aged; Mutation; Oligopeptides; Pyridines; Pyrimidinones; Safety

2009
Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment.
    AIDS (London, England), 2009, Jun-01, Volume: 23, Issue:9

    Topics: Absorptiometry, Photon; Adult; Alkynes; Benzoxazines; Cyclopropanes; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; HIV-Associated Lipodystrophy Syndrome; Humans; Lipid Metabolism; Lopinavir; Male; Pyrimidinones; Ritonavir

2009
First line zidovudine/lamivudine/lopinavir/ritonavir leads to greater bone loss compared to nevirapine/lopinavir/ritonavir.
    AIDS (London, England), 2009, Jul-17, Volume: 23, Issue:11

    Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Bone Density; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Nevirapine; Osteoporosis; Pyrimidinones; Ritonavir; Young Adult; Zidovudine

2009
Protease inhibitor resistance analysis in the MONARK trial comparing first-line lopinavir-ritonavir monotherapy to lopinavir-ritonavir plus zidovudine and lamivudine triple therapy.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:7

    Topics: Drug Resistance, Viral; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Lopinavir; Pyrimidinones; Ritonavir; Treatment Outcome; Zidovudine

2009
Characterization of virologic failure patients on darunavir/ritonavir in treatment-experienced patients.
    AIDS (London, England), 2009, Sep-10, Volume: 23, Issue:14

    Topics: Anti-HIV Agents; Darunavir; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Mutation; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Sulfonamides; Treatment Failure; Viral Load

2009
Effects of switching from lopinavir/ritonavir to atazanavir/ritonavir on muscle glucose uptake and visceral fat in HIV-infected patients.
    AIDS (London, England), 2009, Jul-17, Volume: 23, Issue:11

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Female; Glucose; HIV Infections; HIV Protease Inhibitors; Humans; Intra-Abdominal Fat; Lipid Metabolism; Lopinavir; Male; Middle Aged; Muscle, Skeletal; Oligopeptides; Pyridines; Pyrimidinones; Ritonavir

2009
Zidovudine/lamivudine for HIV-1 infection contributes to limb fat loss.
    PloS one, 2009, May-21, Volume: 4, Issue:5

    Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Biomarkers; Body Composition; Glucose; HIV Infections; HIV-1; Humans; Lamivudine; Lipids; Lipodystrophy; Lopinavir; Male; Middle Aged; Pyrimidinones; Zidovudine

2009
Once-daily darunavir/ritonavir vs. lopinavir/ritonavir in treatment-naive, HIV-1-infected patients: 96-week analysis.
    AIDS (London, England), 2009, Aug-24, Volume: 23, Issue:13

    Topics: Adult; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Darunavir; Drug Administration Schedule; Drug Resistance, Multiple, Viral; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; RNA, Viral; Sulfonamides; Treatment Outcome; Viral Load

2009
Loss of bone mineral density after antiretroviral therapy initiation, independent of antiretroviral regimen.
    Journal of acquired immune deficiency syndromes (1999), 2009, Aug-15, Volume: 51, Issue:5

    Topics: Absorptiometry, Photon; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Bone Density; Cyclopropanes; Female; HIV Infections; Humans; Inflammation Mediators; Lamivudine; Lopinavir; Male; Middle Aged; Osteoporosis; Prospective Studies; Pyrimidinones; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Risk Factors; Ritonavir; Zidovudine

2009
Randomized, double-blind, placebo-matched, multicenter trial of abacavir/lamivudine or tenofovir/emtricitabine with lopinavir/ritonavir for initial HIV treatment.
    AIDS (London, England), 2009, Jul-31, Volume: 23, Issue:12

    Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cardiovascular Diseases; CD4 Lymphocyte Count; Deoxycytidine; Dideoxynucleosides; Double-Blind Method; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lamivudine; Lopinavir; Male; Organophosphonates; Pyrimidinones; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome

2009
Pharmacokinetics and tolerability of once- versus twice-daily lopinavir/ritonavir treatment in HIV-1-infected children.
    Antiviral therapy, 2009, Volume: 14, Issue:4

    Topics: Adolescent; Anti-HIV Agents; Child; Child, Preschool; Cross-Over Studies; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Pyrimidinones; Ritonavir

2009
Modified directly observed antiretroviral therapy compared with self-administered therapy in treatment-naive HIV-1-infected patients: a randomized trial.
    Archives of internal medicine, 2009, Jul-13, Volume: 169, Issue:13

    Topics: Adenine; Administration, Oral; Adolescent; Adult; Aged; Anti-HIV Agents; Deoxycytidine; Dose-Response Relationship, Drug; Emtricitabine; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Organophosphonates; Pyrimidinones; Retrospective Studies; RNA, Viral; Stavudine; Tenofovir; Treatment Outcome; Young Adult

2009
Identification of new genotypic cut-off levels to predict the efficacy of lopinavir/ritonavir and darunavir/ritonavir in the TITAN trial.
    HIV medicine, 2009, Volume: 10, Issue:10

    Topics: Adult; Algorithms; Anti-HIV Agents; CD4 Lymphocyte Count; Darunavir; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Intention to Treat Analysis; Logistic Models; Lopinavir; Male; Mutation; Pyrimidinones; Ritonavir; RNA, Viral; Sensitivity and Specificity; Sulfonamides; Treatment Outcome; Viral Load

2009
Improvement of mitochondrial toxicity in patients receiving a nucleoside reverse-transcriptase inhibitor-sparing strategy: results from the Multicenter Study with Nevirapine and Kaletra (MULTINEKA).
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009, Sep-15, Volume: 49, Issue:6

    Topics: Absorptiometry, Photon; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Body Composition; DNA, Mitochondrial; Drug Therapy, Combination; Electron Transport Complex IV; Extremities; Female; Follow-Up Studies; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Lipids; Lopinavir; Male; Middle Aged; Nevirapine; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Outcome; Viral Load

2009
Long-term (96-week) follow-up of antiretroviral-naïve HIV-infected patients treated with first-line lopinavir/ritonavir monotherapy in the MONARK trial.
    HIV medicine, 2010, Volume: 11, Issue:2

    Topics: Antiretroviral Therapy, Highly Active; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Intention to Treat Analysis; Lamivudine; Lopinavir; Male; Medication Adherence; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Treatment Outcome; Zidovudine

2010
Pharmacokinetics and 48 week efficacy of low-dose lopinavir/ritonavir in HIV-infected children.
    The Journal of antimicrobial chemotherapy, 2009, Volume: 64, Issue:5

    Topics: Adolescent; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Child; Child, Preschool; Female; HIV Infections; Humans; Lamivudine; Lopinavir; Male; Plasma; Pyrimidinones; Ritonavir; RNA, Viral; Treatment Outcome; Viral Load; Zidovudine

2009
Enfuvirtide: a safe and effective antiretroviral agent for human immunodeficiency virus-infected patients shortly after liver transplantation.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2009, Volume: 15, Issue:10

    Topics: Adult; Anti-Retroviral Agents; Cyclosporine; Dose-Response Relationship, Drug; Enfuvirtide; Female; HIV Envelope Protein gp41; HIV Infections; Humans; Immunosuppressive Agents; Liver Failure; Liver Transplantation; Lopinavir; Male; Middle Aged; Peptide Fragments; Pyrimidinones; Ritonavir; Tacrolimus; Treatment Outcome

2009
Pharmacokinetic evaluation of rifabutin in combination with lopinavir-ritonavir in patients with HIV infection and active tuberculosis.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009, Nov-01, Volume: 49, Issue:9

    Topics: Adult; Antibiotics, Antitubercular; Antiviral Agents; Drug Interactions; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Rifabutin; Ritonavir; Tuberculosis

2009
Virological and immunological responses to efavirenz or boosted lopinavir as first-line therapy for patients with HIV.
    Antiviral therapy, 2009, Volume: 14, Issue:6

    Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cohort Studies; Cyclopropanes; Female; HIV Infections; Humans; Lopinavir; Male; Prospective Studies; Pyrimidinones

2009
Modified directly observed therapy to improve HIV treatment outcomes: little impact with potent, once-daily therapy in unselected antiretroviral-naïve patients.
    Current HIV/AIDS reports, 2009, Volume: 6, Issue:4

    Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Directly Observed Therapy; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV-1; Humans; Lopinavir; Medication Adherence; Organophosphonates; Pyrimidinones; Ritonavir; Self Administration; Stavudine; Tenofovir; Treatment Outcome

2009
Plasma concentrations of generic lopinavir/ritonavir in HIV type-1-infected individuals.
    Antiviral therapy, 2009, Volume: 14, Issue:7

    Topics: Adult; Drug Administration Schedule; Drug Combinations; Drugs, Generic; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pilot Projects; Prospective Studies; Pyrimidinones; Ritonavir; Tablets

2009
Lopinavir cerebrospinal fluid steady-state trough concentrations in HIV-infected adults.
    The Annals of pharmacotherapy, 2009, Volume: 43, Issue:12

    Topics: Adult; Area Under Curve; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Inhibitory Concentration 50; Linear Models; Lopinavir; Male; Middle Aged; Prospective Studies; Pyrimidinones; Ritonavir; Time Factors; Virus Replication

2009
Similar antiviral efficacy and tolerability between efavirenz and lopinavir/ritonavir, administered with abacavir/lamivudine (Kivexa), in antiretroviral-naïve patients: a 48-week, multicentre, randomized study (Lake Study).
    Antiviral research, 2010, Volume: 85, Issue:2

    Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Dideoxynucleosides; Drug Combinations; Drug Hypersensitivity; Female; HIV Infections; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; RNA, Viral; Treatment Outcome; Viral Load; Withholding Treatment

2010
Once-daily atazanavir/ritonavir compared with twice-daily lopinavir/ritonavir, each in combination with tenofovir and emtricitabine, for management of antiretroviral-naive HIV-1-infected patients: 96-week efficacy and safety results of the CASTLE study.
    Journal of acquired immune deficiency syndromes (1999), 2010, Volume: 53, Issue:3

    Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lipids; Lopinavir; Male; Middle Aged; Oligopeptides; Organophosphonates; Pyridines; Pyrimidinones; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load; Young Adult

2010
Switch to a raltegravir-based regimen versus continuation of a lopinavir-ritonavir-based regimen in stable HIV-infected patients with suppressed viraemia (SWITCHMRK 1 and 2): two multicentre, double-blind, randomised controlled trials.
    Lancet (London, England), 2010, Jan-30, Volume: 375, Issue:9712

    Topics: Adult; Anti-HIV Agents; Cholesterol, LDL; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Pyrrolidinones; Raltegravir Potassium; Ritonavir; RNA, Viral; Treatment Outcome; Viremia

2010
Prospective, randomized, open label trial of Efavirenz vs Lopinavir/Ritonavir in HIV+ treatment-naive subjects with CD4+<200 cell/mm3 in Mexico.
    Journal of acquired immune deficiency syndromes (1999), 2010, Volume: 53, Issue:5

    Topics: Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cyclopropanes; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Mexico; Prospective Studies; Pyrimidinones; Ritonavir; RNA, Viral

2010
Similar safety and efficacy of once- and twice-daily lopinavir/ritonavir tablets in treatment-experienced HIV-1-infected subjects at 48 weeks.
    Journal of acquired immune deficiency syndromes (1999), 2010, Volume: 54, Issue:2

    Topics: Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Drug Resistance, Viral; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Medication Adherence; Middle Aged; Nausea; Pyrimidinones; Ritonavir; Viral Load; Young Adult

2010
Effects of intermittent IL-2 alone or with peri-cycle antiretroviral therapy in early HIV infection: the STALWART study.
    PloS one, 2010, Feb-23, Volume: 5, Issue:2

    Topics: Adult; Anti-HIV Agents; Atazanavir Sulfate; Carbamates; CD4 Lymphocyte Count; Drug Administration Schedule; Drug Therapy, Combination; Female; Fever; Furans; HIV Infections; Humans; Interleukin-2; Lopinavir; Male; Nausea; Oligopeptides; Opportunistic Infections; Organophosphates; Pyridines; Pyrimidinones; Ritonavir; Sulfonamides; Treatment Outcome

2010
Comparison of once-daily versus twice-daily combination antiretroviral therapy in treatment-naive patients: results of AIDS clinical trials group (ACTG) A5073, a 48-week randomized controlled trial.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2010, Apr-01, Volume: 50, Issue:7

    Topics: Anti-Retroviral Agents; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV; HIV Infections; Humans; Lopinavir; Male; Proportional Hazards Models; Pyrimidinones; Ritonavir; RNA, Viral; Treatment Outcome; Viral Load

2010
Initial response to protease-inhibitor-based antiretroviral therapy among children less than 2 years of age in South Africa: effect of cotreatment for tuberculosis.
    The Journal of infectious diseases, 2010, Apr-15, Volume: 201, Issue:8

    Topics: Antiretroviral Therapy, Highly Active; Antitubercular Agents; Child, Preschool; Drug Therapy, Combination; Ethionamide; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Infant; Isoniazid; Kaplan-Meier Estimate; Lopinavir; Male; Pyrimidinones; Rifampin; Ritonavir; RNA, Viral; South Africa; Tuberculosis, Pulmonary; Viral Load

2010
No significant effect of uridine or pravastatin treatment for HIV lipoatrophy in men who have ceased thymidine analogue nucleoside reverse transcriptase inhibitor therapy: a randomized trial.
    HIV medicine, 2010, Volume: 11, Issue:8

    Topics: Absorptiometry, Photon; Adiposity; Adult; Anti-Retroviral Agents; Anticholesteremic Agents; Dideoxynucleosides; Drug Therapy, Combination; Extremities; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Lopinavir; Male; Middle Aged; Pravastatin; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Uridine

2010
Impact of 48 week lopinavir/ritonavir monotherapy on blood cell-associated HIV-1-DNA in the MONARK trial.
    The Journal of antimicrobial chemotherapy, 2010, Volume: 65, Issue:5

    Topics: Anti-HIV Agents; Blood Cells; DNA, Viral; HIV Infections; HIV-1; Humans; Lopinavir; Polymerase Chain Reaction; Pyrimidinones; Ritonavir; Viral Load

2010
Pharmacokinetics of lopinavir-ritonavir with and without nonnucleoside reverse transcriptase inhibitors in Ugandan HIV-infected adults.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:7

    Topics: Adult; Aged; Alkynes; Benzoxazines; Chromatography, High Pressure Liquid; Cyclopropanes; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Nevirapine; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Uganda

2010
Differential effects of efavirenz, lopinavir/r, and atazanavir/r on the initial viral decay rate in treatment naïve HIV-1-infected patients.
    AIDS research and human retroviruses, 2010, Volume: 26, Issue:5

    Topics: Adult; Aged; Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Oligopeptides; Pyridines; Pyrimidinones; Reverse Transcriptase Inhibitors; RNA, Viral; Treatment Outcome

2010
Gastrointestinal tolerability and quality of life in antiretroviral-naive HIV-1-infected patients: data from the CASTLE study.
    AIDS care, 2010, Volume: 22, Issue:6

    Topics: Adenine; Adult; Aged; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; Gastrointestinal Diseases; HIV Infections; HIV-1; Humans; Irritable Bowel Syndrome; Lopinavir; Male; Medication Adherence; Middle Aged; Oligopeptides; Organophosphonates; Prospective Studies; Pyridines; Pyrimidinones; Quality of Life; Ritonavir; Surveys and Questionnaires; Tenofovir; Young Adult

2010
Suboptimal adherence to darunavir/ritonavir has minimal effect on efficacy compared with lopinavir/ritonavir in treatment-naive, HIV-infected patients: 96 week ARTEMIS data.
    The Journal of antimicrobial chemotherapy, 2010, Volume: 65, Issue:7

    Topics: Adult; Anti-HIV Agents; Darunavir; HIV Infections; HIV-1; Humans; Lopinavir; Medication Adherence; Pyrimidinones; Ritonavir; Sulfonamides; Treatment Outcome; Viral Load

2010
Long-term safety and effectiveness of lopinavir/ritonavir in antiretroviral-experienced HIV-1-infected children.
    Archives of disease in childhood, 2010, Volume: 95, Issue:6

    Topics: Adolescent; CD4 Lymphocyte Count; Child; Child, Preschool; Drug Therapy, Combination; Female; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Prospective Studies; Pyrimidinones; Ritonavir; Treatment Outcome; Viral Load

2010
Pharmacokinetics and virologic response of zidovudine/lopinavir/ritonavir initiated during the third trimester of pregnancy.
    AIDS (London, England), 2010, Sep-10, Volume: 24, Issue:14

    Topics: Adult; CD4-Positive T-Lymphocytes; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Infectious Disease Transmission, Vertical; Lopinavir; Pregnancy; Pregnancy Trimester, Third; Prospective Studies; Pyrimidinones; Ritonavir; RNA, Viral; Thailand; Viral Load; Young Adult; Zidovudine

2010
Short communication: Comparable safety and efficacy with once-daily versus twice-daily dosing of lopinavir/ritonavir tablets with emtricitabine + tenofovir DF in antiretroviral-naïve, HIV type 1-infected subjects: 96 week final results of the randomized t
    AIDS research and human retroviruses, 2010, Volume: 26, Issue:8

    Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Emtricitabine; HIV Infections; HIV-1; Humans; Lopinavir; Organophosphonates; Pyrimidinones; Ritonavir; Tenofovir

2010
Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir.
    European journal of clinical pharmacology, 2010, Volume: 66, Issue:10

    Topics: Adult; Analgesics, Opioid; Area Under Curve; Cross-Over Studies; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Female; Finland; HIV Infections; HIV Protease Inhibitors; Humans; Linear Models; Lopinavir; Male; Oxycodone; Pain; Pyrimidinones; Reference Values; Ritonavir; Time Factors; Young Adult

2010
Bone mineral density changes in protease inhibitor-sparing vs. nucleoside reverse transcriptase inhibitor-sparing highly active antiretroviral therapy: data from a randomized trial.
    HIV medicine, 2011, Volume: 12, Issue:3

    Topics: Absorptiometry, Photon; Adult; Alkynes; Antiretroviral Therapy, Highly Active; Benzoxazines; Bone Density; Cyclopropanes; Female; HIV Infections; HIV-1; Humans; Lamivudine; Lopinavir; Male; Pyrimidinones; Ritonavir; Zidovudine

2011
Therapeutic drug monitoring of lopinavir/ritonavir in pregnancy.
    HIV medicine, 2011, Volume: 12, Issue:3

    Topics: Adult; Anti-HIV Agents; Chromatography, High Pressure Liquid; Drug Monitoring; Female; HIV Infections; HIV-1; Humans; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Pyrimidinones; Ritonavir; Young Adult

2011
Randomized controlled study demonstrating failure of LPV/r monotherapy in HIV: the role of compartment and CD4-nadir.
    AIDS (London, England), 2010, Sep-24, Volume: 24, Issue:15

    Topics: Adult; CD4 Lymphocyte Count; Drug Administration Schedule; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; RNA, Viral; Semen; Time Factors; Treatment Failure; Viral Load

2010
Reuse of nevirapine in exposed HIV-infected children after protease inhibitor-based viral suppression: a randomized controlled trial.
    JAMA, 2010, Sep-08, Volume: 304, Issue:10

    Topics: Anti-HIV Agents; Child, Preschool; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Infant; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Male; Maternal Exposure; Nevirapine; Protease Inhibitors; Pyrimidinones; RNA, Viral; Stavudine; Treatment Outcome; Viremia

2010
Contraceptive efficacy of oral and transdermal hormones when co-administered with protease inhibitors in HIV-1-infected women: pharmacokinetic results of ACTG trial A5188.
    Journal of acquired immune deficiency syndromes (1999), 2010, Volume: 55, Issue:4

    Topics: Adolescent; Adult; Contraceptives, Oral, Combined; Drug Combinations; Drug Interactions; Estrogens; Ethinyl Estradiol; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Middle Aged; Norgestrel; Oximes; Pyrimidinones; Ritonavir; Transdermal Patch; United States

2010
Lopinavir/ritonavir monotherapy versus current treatment continuation for maintenance therapy of HIV-1 infection: the KALESOLO trial.
    The Journal of antimicrobial chemotherapy, 2010, Volume: 65, Issue:11

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; France; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; RNA, Viral; Treatment Outcome; Viral Load

2010
Treatment intensification has no effect on the HIV-1 central nervous system infection in patients on suppressive antiretroviral therapy.
    Journal of acquired immune deficiency syndromes (1999), 2010, Dec-15, Volume: 55, Issue:5

    Topics: Adult; Albumins; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Central Nervous System Infections; Cross-Over Studies; Cyclohexanes; Enfuvirtide; Female; HIV Envelope Protein gp41; HIV Infections; HIV-1; Humans; Immunoglobulin G; Lopinavir; Male; Maraviroc; Middle Aged; Neopterin; Peptide Fragments; Polymerase Chain Reaction; Ritonavir; RNA, Viral; Triazoles; Viral Load; Viremia; Virus Replication

2010
Safety and effectiveness of antiretroviral drugs during pregnancy, delivery and breastfeeding for prevention of mother-to-child transmission of HIV-1: the Kesho Bora Multicentre Collaborative Study rationale, design, and implementation challenges.
    Contemporary clinical trials, 2011, Volume: 32, Issue:1

    Topics: Africa, Eastern; Africa, Southern; Africa, Western; Anti-Retroviral Agents; Breast Feeding; Child, Preschool; Clinical Protocols; Cohort Studies; Delivery, Obstetric; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Mothers; Nevirapine; Pregnancy; Pyrimidinones; Research Design; Ritonavir; Zidovudine

2011
Antiretroviral therapies in women after single-dose nevirapine exposure.
    The New England journal of medicine, 2010, Oct-14, Volume: 363, Issue:16

    Topics: Adenine; Adult; Anti-HIV Agents; Anti-Retroviral Agents; CD4 Lymphocyte Count; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Infectious Disease Transmission, Vertical; Kaplan-Meier Estimate; Linear Models; Lopinavir; Nevirapine; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Pyrimidinones; Ritonavir; Statistics, Nonparametric; Tenofovir; Treatment Failure; Young Adult

2010
Antiretroviral treatment for children with peripartum nevirapine exposure.
    The New England journal of medicine, 2010, Oct-14, Volume: 363, Issue:16

    Topics: Anti-HIV Agents; Anti-Retroviral Agents; Child, Preschool; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Kaplan-Meier Estimate; Lopinavir; Male; Nevirapine; Pregnancy; Pregnancy Complications, Infectious; Pyrimidinones; Ritonavir; RNA, Viral; Treatment Failure

2010
Beneficial effects of a switch to a Lopinavir/ritonavir-containing regimen for patients with partial or no immune reconstitution with highly active antiretroviral therapy despite complete viral suppression.
    AIDS research and human retroviruses, 2011, Volume: 27, Issue:6

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; RNA, Viral; Treatment Outcome; Viral Load

2011
Comparative gender analysis of the efficacy and safety of atazanavir/ritonavir and lopinavir/ritonavir at 96 weeks in the CASTLE study.
    The Journal of antimicrobial chemotherapy, 2011, Volume: 66, Issue:2

    Topics: Adult; Aged; Anti-HIV Agents; Atazanavir Sulfate; CD4 Lymphocyte Count; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Oligopeptides; Pyridines; Pyrimidinones; Ritonavir; Sex Factors

2011
Effect of boosted fosamprenavir or lopinavir-based combinations on whole-body insulin sensitivity and lipids in treatment-naive HIV-type-1-positive men.
    Antiviral therapy, 2010, Volume: 15, Issue:8

    Topics: Adenine; Adipose Tissue; Adult; Anti-HIV Agents; Blood Glucose; Carbamates; Confidence Intervals; Drug Administration Schedule; Drug Combinations; Dyslipidemias; Furans; HIV Infections; HIV-1; Humans; Insulin; Insulin Resistance; Lamivudine; Lipids; Lopinavir; Male; Organophosphates; Organophosphonates; Pyrimidinones; Ritonavir; Sulfonamides; Tenofovir

2010
In vitro susceptibility and virological outcome to darunavir and lopinavir are independent of HIV type-1 subtype in treatment-naive patients.
    Antiviral therapy, 2010, Volume: 15, Issue:8

    Topics: Adamantane; Adult; Analysis of Variance; Atazanavir Sulfate; Carbamates; Darunavir; Drug Resistance, Viral; Furans; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lopinavir; Microbial Sensitivity Tests; Molecular Typing; Nelfinavir; Neuraminidase; Oligopeptides; Pyridines; Pyrimidinones; Pyrones; Saquinavir; Sulfonamides; Viral Load

2010
Fat tissue distribution changes in HIV-infected patients treated with lopinavir/ritonavir. Results of the MONARK trial.
    Current HIV research, 2011, Volume: 9, Issue:1

    Topics: Absorptiometry, Photon; Adult; Anti-HIV Agents; Body Fat Distribution; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; Zidovudine

2011
Immune activation mediated change in alpha-1-acid glycoprotein: impact on total and free lopinavir plasma exposure.
    Journal of clinical pharmacology, 2011, Volume: 51, Issue:11

    Topics: Adult; Anti-HIV Agents; Area Under Curve; CD4-Positive T-Lymphocytes; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Orosomucoid; Prospective Studies; Protein Binding; Ritonavir; RNA, Viral

2011
Sex differences in lopinavir and ritonavir pharmacokinetics among HIV-infected women and men.
    Journal of clinical pharmacology, 2011, Volume: 51, Issue:12

    Topics: Adolescent; Adult; Area Under Curve; Capsules; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Ritonavir; Sex Factors; Tablets; Young Adult

2011
Long-term outcomes for HIV-infected infants less than 6 months of age at initiation of lopinavir/ritonavir combination antiretroviral therapy.
    AIDS (London, England), 2011, Mar-13, Volume: 25, Issue:5

    Topics: Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Infant; Infant, Newborn; Lopinavir; Male; Pyrimidinones; Ritonavir; Treatment Outcome; Viral Load

2011
Virological characterization of patients failing darunavir/ritonavir or lopinavir/ritonavir treatment in the ARTEMIS study: 96-week analysis.
    Antiviral therapy, 2011, Volume: 16, Issue:1

    Topics: Adenine; Adult; Anti-HIV Agents; Darunavir; Deoxycytidine; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Genetic Association Studies; HIV Infections; HIV-1; Humans; Lopinavir; Male; Mutation; Organophosphonates; Polymorphism, Genetic; Pyrimidinones; Ritonavir; RNA, Viral; Sulfonamides; Tenofovir; Treatment Failure; Viral Load

2011
High efficacy of lopinavir/r-based second-line antiretroviral treatment after 24 months of follow up at ESTHER/Calmette Hospital in Phnom Penh, Cambodia.
    Journal of the International AIDS Society, 2011, Mar-26, Volume: 14

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cambodia; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cohort Studies; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Treatment Outcome; Viral Load

2011
Pharmacokinetics of lopinavir in HIV-infected adults receiving rifampin with adjusted doses of lopinavir-ritonavir tablets.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:7

    Topics: Adult; Anti-HIV Agents; Female; HIV Infections; Humans; Lopinavir; Male; Pyrimidinones; Rifampin; Ritonavir; Tablets

2011
Genotypic resistance at viral rebound among patients who received lopinavir/ritonavir-based or efavirenz-based first antiretroviral therapy in South Africa.
    Journal of acquired immune deficiency syndromes (1999), 2011, Nov-01, Volume: 58, Issue:3

    Topics: Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Drug Resistance, Viral; Female; HIV Infections; Humans; Lopinavir; Male; Mutation; Ritonavir; RNA, Viral; South Africa; Treatment Failure; Viral Load

2011
Treatment of advanced HIV disease in antiretroviral-naïve HIV-1-infected patients receiving once-daily atazanavir/ritonavir or twice-daily lopinavir/ritonavir, each in combination with tenofovir disoproxil fumarate and emtricitabine.
    AIDS care, 2011, Volume: 23, Issue:11

    Topics: Adenine; Adult; Aged; Antiviral Agents; Atazanavir Sulfate; CD4 Lymphocyte Count; Deoxycytidine; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Oligopeptides; Organophosphonates; Prospective Studies; Pyridines; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome; Young Adult

2011
Randomized trial of time-limited interruptions of protease inhibitor-based antiretroviral therapy (ART) vs. continuous therapy for HIV-1 infection.
    PloS one, 2011, Volume: 6, Issue:6

    Topics: Anti-HIV Agents; CD4-Positive T-Lymphocytes; HIV Infections; Lamivudine; Lopinavir; Protease Inhibitors; Ritonavir; Stavudine; Zidovudine

2011
Pharmacokinetics and virological efficacy after switch to once-daily lopinavir-ritonavir in treatment-experienced HIV-1-infected children.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:9

    Topics: Adolescent; Adult; Anti-HIV Agents; Child; Child, Preschool; Drug Administration Schedule; Female; HIV Infections; Humans; Infant; Lopinavir; Male; Ritonavir; Treatment Outcome; Young Adult

2011
Pharmacokinetics of lopinavir/ritonavir crushed versus whole tablets in children.
    Journal of acquired immune deficiency syndromes (1999), 2011, Dec-01, Volume: 58, Issue:4

    Topics: Adolescent; Anti-HIV Agents; Child; Cross-Over Studies; Drug Combinations; Female; HIV Infections; Humans; Lopinavir; Male; Ritonavir; Tablets; Treatment Outcome

2011
Pilot, randomized study assessing safety, tolerability and efficacy of simplified LPV/r maintenance therapy in HIV patients on the 1 PI-based regimen.
    PloS one, 2011, Volume: 6, Issue:8

    Topics: Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug-Related Side Effects and Adverse Reactions; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Pilot Projects; Precision Medicine; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Outcome; Young Adult

2011
Initial viral decay to assess the relative antiretroviral potency of protease inhibitor-sparing, nonnucleoside reverse transcriptase inhibitor-sparing, and nucleoside reverse transcriptase inhibitor-sparing regimens for first-line therapy of HIV infection
    AIDS (London, England), 2011, Nov-28, Volume: 25, Issue:18

    Topics: Adult; Alkynes; Benzoxazines; Cyclopropanes; Drug Therapy, Combination; Female; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Sex Factors; Treatment Outcome; Viral Load

2011
Virological response and resistance profiles after 24 months of first-line antiretroviral treatment in adults living in Bangui, Central African Republic.
    AIDS research and human retroviruses, 2012, Volume: 28, Issue:4

    Topics: Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; CD4 Lymphocyte Count; Central African Republic; DNA Fingerprinting; Drug Resistance, Viral; Female; Genetic Variation; Health Services Accessibility; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Medication Adherence; Oligopeptides; Organophosphonates; Prospective Studies; Pyridines; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Viral Load; Young Adult; Zidovudine

2012
Non-linear mixed effects modeling of antiretroviral drug response after administration of lopinavir, atazanavir and efavirenz containing regimens to treatment-naïve HIV-1 infected patients.
    Journal of pharmacokinetics and pharmacodynamics, 2011, Volume: 38, Issue:6

    Topics: Adult; Aged; Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Limit of Detection; Lopinavir; Male; Middle Aged; Nonlinear Dynamics; Oligopeptides; Pyridines; Ritonavir; RNA, Viral; Viral Load

2011
Efficacy and safety of once daily elvitegravir versus twice daily raltegravir in treatment-experienced patients with HIV-1 receiving a ritonavir-boosted protease inhibitor: randomised, double-blind, phase 3, non-inferiority study.
    The Lancet. Infectious diseases, 2012, Volume: 12, Issue:1

    Topics: Adult; Alanine Transaminase; Anti-Retroviral Agents; Aspartate Aminotransferases; Atazanavir Sulfate; CD4 Lymphocyte Count; Diarrhea; Double-Blind Method; Drug Therapy, Combination; Female; HIV Infections; HIV Integrase Inhibitors; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Oligopeptides; Pyridines; Pyrrolidinones; Quinolones; Raltegravir Potassium; Ritonavir; RNA, Viral; Treatment Outcome; Viral Load

2012
Neither branded nor generic lopinavir/ritonavir produces adequate lopinavir concentrations at a reduced dose of 200/50 mg twice daily.
    Journal of acquired immune deficiency syndromes (1999), 2012, Jan-01, Volume: 59, Issue:1

    Topics: Adult; Anti-HIV Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Ritonavir; Therapeutic Equivalency

2012
Improved oral bioavailability of lopinavir in melt-extruded tablet formulation reduces impact of third trimester on lopinavir plasma concentrations.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:2

    Topics: Adolescent; Anti-HIV Agents; Biological Availability; Capsules; Cohort Studies; Dose-Response Relationship, Drug; Female; Gelatin; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Tablets; Viral Load; Young Adult

2012
Pharmacokinetics and inhibitory quotient of atazanavir/ritonavir versus lopinavir/ritonavir in HIV-infected, treatment-naive patients who participated in the CASTLE Study.
    The Journal of antimicrobial chemotherapy, 2012, Volume: 67, Issue:2

    Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; Tenofovir

2012
HIV-1 protease inhibitors and clinical malaria: a secondary analysis of the AIDS Clinical Trials Group A5208 study.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:2

    Topics: Adenine; Adult; Anti-HIV Agents; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Incidence; Lopinavir; Malaria; Nevirapine; Organophosphonates; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Treatment Outcome

2012
Lipid profiles in young HIV-infected children initiating and changing antiretroviral therapy.
    Journal of acquired immune deficiency syndromes (1999), 2012, Aug-01, Volume: 60, Issue:4

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Child, Preschool; Cohort Studies; Female; HIV Infections; Humans; Infant; Lipids; Lopinavir; Male; Ritonavir; South Africa; Treatment Outcome

2012
The setpoint study (ACTG A5217): effect of immediate versus deferred antiretroviral therapy on virologic set point in recently HIV-1-infected individuals.
    The Journal of infectious diseases, 2012, Jan-01, Volume: 205, Issue:1

    Topics: Adenine; Adult; Anti-HIV Agents; Deoxycytidine; Disease Progression; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Organophosphonates; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load

2012
Post-exposure prophylaxis for HIV infection: a clinical trial comparing lopinavir/ritonavir versus atazanavir each with zidovudine/lamivudine.
    Antiviral therapy, 2012, Volume: 17, Issue:2

    Topics: Adult; Anti-HIV Agents; Atazanavir Sulfate; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Male; Oligopeptides; Post-Exposure Prophylaxis; Pyridines; Ritonavir; Zidovudine

2012
HIV-1 tropism and CD4 T lymphocyte recovery in a prospective cohort of patients initiating HAART in Ribeirão Preto, Brazil.
    Memorias do Instituto Oswaldo Cruz, 2012, Volume: 107, Issue:1

    Topics: Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; Cohort Studies; Cyclopropanes; Double-Blind Method; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Prospective Studies; Treatment Outcome; Viral Load; Viral Tropism

2012
Week 96 efficacy, virology and safety of darunavir/r versus lopinavir/r in treatment-experienced patients in TITAN.
    Current HIV research, 2012, Volume: 10, Issue:2

    Topics: Adult; CD4 Lymphocyte Count; Darunavir; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Logistic Models; Lopinavir; Male; Middle Aged; Ritonavir; RNA, Viral; Sulfonamides; Viral Load

2012
Switching children previously exposed to nevirapine to nevirapine-based treatment after initial suppression with a protease-inhibitor-based regimen: long-term follow-up of a randomised, open-label trial.
    The Lancet. Infectious diseases, 2012, Volume: 12, Issue:7

    Topics: Alanine Transaminase; Anti-HIV Agents; Body Height; Body Weight; Chi-Square Distribution; Child, Preschool; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; Humans; Infant; Kaplan-Meier Estimate; Lopinavir; Male; Medication Adherence; Nevirapine; Ritonavir; Statistics, Nonparametric; Time Factors; Viral Load

2012
Steady-state pharmacokinetics of lopinavir plus ritonavir when administered under different meal conditions in HIV-infected Ugandan adults.
    Journal of acquired immune deficiency syndromes (1999), 2012, Jul-01, Volume: 60, Issue:3

    Topics: Adult; Anti-HIV Agents; Cross-Over Studies; Dietary Fats; Drug Administration Schedule; Eating; Fasting; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Ritonavir; Uganda

2012
The frequency of malaria is similar among women receiving either lopinavir/ritonavir or nevirapine-based antiretroviral treatment.
    PloS one, 2012, Volume: 7, Issue:4

    Topics: Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Malaria; Nevirapine; Ritonavir

2012
Nevirapine versus ritonavir-boosted lopinavir for HIV-infected children.
    The New England journal of medicine, 2012, Jun-21, Volume: 366, Issue:25

    Topics: Anti-Retroviral Agents; CD4 Lymphocyte Count; Child, Preschool; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Infant; Kaplan-Meier Estimate; Lamivudine; Lopinavir; Male; Nevirapine; Ritonavir; RNA, Viral; Zidovudine

2012
Nevirapine- versus lopinavir/ritonavir-based initial therapy for HIV-1 infection among women in Africa: a randomized trial.
    PLoS medicine, 2012, Volume: 9, Issue:6

    Topics: Adult; Africa; Anti-HIV Agents; CD4 Lymphocyte Count; Death; Drug Resistance, Viral; Endpoint Determination; Female; HIV Infections; HIV-1; Humans; Kaplan-Meier Estimate; Lopinavir; Medication Adherence; Mutation; Nevirapine; Ritonavir

2012
Treatment outcomes among HIV-1 and HIV-2 infected children initiating antiretroviral therapy in a concentrated low prevalence setting in West Africa.
    BMC pediatrics, 2012, Jul-08, Volume: 12

    Topics: Adolescent; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Child; Child, Preschool; Cohort Studies; Cyclopropanes; Drug Combinations; Female; Follow-Up Studies; Gambia; HIV Infections; HIV-1; HIV-2; Humans; Infant; Kaplan-Meier Estimate; Lamivudine; Lopinavir; Male; Nevirapine; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Outcome; Viral Load; Zidovudine

2012
Lopinavir/ritonavir monotherapy after 24 weeks of second-line antiretroviral therapy in Africa: a randomized controlled trial (SARA).
    Antiviral therapy, 2012, Volume: 17, Issue:7

    Topics: Adult; Africa; CD4 Lymphocyte Count; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Mutation; Ritonavir; RNA, Viral; Time Factors; Treatment Outcome; Viral Load; Viremia

2012
Switching to tenofovir/emtricitabine from abacavir/lamivudine in HIV-infected adults with raised cholesterol: effect on lipid profiles.
    Antiviral therapy, 2012, Volume: 17, Issue:6

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cholesterol; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Drug Substitution; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Female; HIV; HIV Infections; Humans; Lamivudine; Lipids; Lopinavir; Male; Medication Adherence; Middle Aged; Organophosphorus Compounds; Ritonavir; Treatment Outcome

2012
Once- versus twice-daily lopinavir/ritonavir tablets in virologically suppressed, HIV-infected, treatment-experienced children: comparative pharmacokinetics and virological outcome after switching to once-daily lopinavir/ritonavir.
    The Journal of antimicrobial chemotherapy, 2012, Volume: 67, Issue:12

    Topics: Adolescent; Anti-HIV Agents; CD4 Lymphocyte Count; Child; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Plasma; Ritonavir; Tablets; Treatment Outcome; Viral Load

2012
Neurocognitive impairment in patients randomized to second-line lopinavir/ritonavir-based antiretroviral therapy vs. lopinavir/ritonavir monotherapy.
    Journal of neurovirology, 2012, Volume: 18, Issue:6

    Topics: Adenine; Adult; CD4 Lymphocyte Count; Cognition Disorders; Depression; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Tenofovir; Viral Load

2012
Marked increase of the astrocytic marker S100B in the cerebrospinal fluid of HIV-infected patients on LPV/r-monotherapy.
    AIDS (London, England), 2013, Jan-14, Volume: 27, Issue:2

    Topics: Amyloid beta-Peptides; Antiretroviral Therapy, Highly Active; Astrocytes; Biomarkers; Enzyme-Linked Immunosorbent Assay; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Neopterin; Peptide Fragments; Ritonavir; S100 Proteins; Switzerland; tau Proteins; Thailand

2013
Lopinavir/Ritonavir versus Lamivudine peri-exposure prophylaxis to prevent HIV-1 transmission by breastfeeding: the PROMISE-PEP trial Protocol ANRS 12174.
    BMC infectious diseases, 2012, Oct-06, Volume: 12

    Topics: Africa; Anti-HIV Agents; Breast Feeding; Chemoprevention; Female; HIV Infections; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Male; Pregnancy; Ritonavir; Treatment Outcome

2012
A randomized comparison of second-line lopinavir/ritonavir monotherapy versus tenofovir/lamivudine/lopinavir/ritonavir in patients failing NNRTI regimens: the HIV STAR study.
    Antiviral therapy, 2012, Volume: 17, Issue:7

    Topics: Adenine; Adult; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Lopinavir; Male; Organophosphonates; Ritonavir; Tenofovir

2012
Final 192-week efficacy and safety of once-daily darunavir/ritonavir compared with lopinavir/ritonavir in HIV-1-infected treatment-naïve patients in the ARTEMIS trial.
    HIV medicine, 2013, Volume: 14, Issue:1

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Darunavir; Drug Administration Schedule; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Protease Inhibitors; Ritonavir; RNA, Viral; Sulfonamides; Viral Load

2013
HAART simplification with lopinavir/ritonavir monotherapy in HIV/HCV co-infected patients starting anti-HCV treatment: a randomised pilot study (KaMon study).
    The new microbiologica, 2012, Volume: 35, Issue:4

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Coinfection; Female; Hepacivirus; Hepatitis C; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pilot Projects; Prospective Studies; Ritonavir; Young Adult

2012
Intensification of antiretroviral therapy through addition of enfuvirtide in naive HIV-1-infected patients with severe immunosuppression does not improve immunological response: results of a randomized multicenter trial (ANRS 130 Apollo).
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:2

    Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cyclopropanes; Deoxycytidine; Drug Combinations; Emtricitabine; Enfuvirtide; Female; HIV Envelope Protein gp41; HIV Infections; HIV-1; Humans; Immune Tolerance; Lopinavir; Male; Organophosphonates; Peptide Fragments; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load

2013
Therapeutic levels of lopinavir in late pregnancy and abacavir passage into breast milk in the Mma Bana Study, Botswana.
    Antiviral therapy, 2013, Volume: 18, Issue:4

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Botswana; Breast Feeding; Dideoxynucleosides; Female; HIV Infections; HIV-1; Humans; Infant; Lactation; Lamivudine; Lopinavir; Middle Aged; Milk, Human; Nevirapine; Pregnancy; Pregnancy Complications, Infectious; Viral Load; Zidovudine

2013
Antiretroviral agents and prevention of malaria in HIV-infected Ugandan children.
    The New England journal of medicine, 2012, Nov-29, Volume: 367, Issue:22

    Topics: Anti-Retroviral Agents; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Child, Preschool; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; HIV Infections; HIV Protease Inhibitors; Humans; Incidence; Infant; Kaplan-Meier Estimate; Lopinavir; Malaria; Male; Reverse Transcriptase Inhibitors; Ritonavir; Secondary Prevention; Uganda

2012
Metabolic abnormalities and body composition of HIV-infected children on Lopinavir or Nevirapine-based antiretroviral therapy.
    Archives of disease in childhood, 2013, Volume: 98, Issue:4

    Topics: Anti-HIV Agents; Body Composition; Child; Child, Preschool; Cross-Sectional Studies; Drug Therapy, Combination; Female; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Infant; Insulin Resistance; Lamivudine; Lipids; Lopinavir; Male; Nevirapine; Ritonavir; South Africa; Stavudine

2013
HIV protease inhibitors do not cause the accumulation of prelamin A in PBMCs from patients receiving first line therapy: the ANRS EP45 "aging" study.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Aging; Atazanavir Sulfate; Carbamates; Cross-Sectional Studies; Female; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Lamin Type A; Leukocytes, Mononuclear; Longitudinal Studies; Lopinavir; Male; Nuclear Proteins; Oligopeptides; Protein Precursors; Pyridines; Ritonavir; Sulfonamides; Viral Load

2012
Switching to lopinavir/ritonavir with or without abacavir/lamivudine in lipoatrophic patients treated with zidovudine/abacavir/lamivudine.
    The Journal of antimicrobial chemotherapy, 2013, Volume: 68, Issue:6

    Topics: Absorptiometry, Photon; Adipose Tissue; Adult; Antiretroviral Therapy, Highly Active; Atrophy; Body Composition; Chemistry, Pharmaceutical; Dideoxynucleosides; Female; HIV Infections; HIV Protease Inhibitors; Humans; Intention to Treat Analysis; Lamivudine; Lipids; Lipodystrophy; Lopinavir; Male; Middle Aged; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Failure

2013
Human immunodeficiency virus type 1 genotypic and pharmacokinetic determinants of the virological response to lopinavir-ritonavir-containing therapy in protease inhibitor-experienced patients.
    Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:9

    Topics: Adult; Amino Acid Substitution; Anti-HIV Agents; Drug Combinations; Female; Genotype; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Models, Biological; Pyrimidinones; Ritonavir; RNA, Viral; Salvage Therapy

2002
Analysis of the virological response with respect to baseline viral phenotype and genotype in protease inhibitor-experienced HIV-1-infected patients receiving lopinavir/ritonavir therapy.
    Antiviral therapy, 2002, Volume: 7, Issue:3

    Topics: Drug Resistance, Viral; Drug Therapy, Combination; Genes, Viral; Genotype; HIV; HIV Infections; HIV Protease; HIV Protease Inhibitors; Humans; Inhibitory Concentration 50; Logistic Models; Lopinavir; Mutation; Phenotype; Pyrimidinones; Ritonavir; RNA, Viral; Time Factors; Viral Load

2002
Pharmacokinetic-pharmacodynamic analysis of lopinavir-ritonavir in combination with efavirenz and two nucleoside reverse transcriptase inhibitors in extensively pretreated human immunodeficiency virus-infected patients.
    Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:1

    Topics: Adult; Alkynes; Area Under Curve; Benzoxazines; Biological Availability; Cyclopropanes; Drug Interactions; Drug Therapy, Combination; HIV Infections; HIV Reverse Transcriptase; Humans; Logistic Models; Lopinavir; Oxazines; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir

2003
The efficacy of lopinavir in individuals experiencing protease inhibitor failure.
    Journal of acquired immune deficiency syndromes (1999), 2003, Feb-01, Volume: 32, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Protease Inhibitors; Pyrimidinones; Ritonavir; Treatment Failure

2003
Forty-eight-week evaluation of lopinavir/ritonavir, a new protease inhibitor, in human immunodeficiency virus-infected children.
    The Pediatric infectious disease journal, 2003, Volume: 22, Issue:3

    Topics: Administration, Oral; Biological Availability; Chemistry, Pharmaceutical; Child; Child, Preschool; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; HIV Infections; Humans; Infant; Lopinavir; Male; Maximum Tolerated Dose; Multivariate Analysis; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Severity of Illness Index; Time Factors; Treatment Outcome; Viral Load

2003
The safety and tolerability of switching from a non-failing antiretroviral regimen to lopinavir.
    The Journal of infection, 2003, Volume: 46, Issue:3

    Topics: Adult; CD4 Lymphocyte Count; Cholesterol; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Triglycerides; Viral Load

2003
Determining the relative efficacy of highly active antiretroviral therapy.
    The Journal of infectious diseases, 2003, Mar-15, Volume: 187, Issue:6

    Topics: Adenine; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cohort Studies; Cyclopropanes; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Organophosphonates; Organophosphorus Compounds; Oxazines; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome

2003
Incidence of hyperlipidaemia in a cohort of 212 HIV-infected patients receiving a protease inhibitor-based antiretroviral therapy.
    International journal of antimicrobial agents, 2003, Volume: 22, Issue:1

    Topics: Adult; Antiretroviral Therapy, Highly Active; Cholesterol; Cholesterol, LDL; Cohort Studies; Female; HIV Infections; HIV Protease Inhibitors; Humans; Hyperlipidemias; Lopinavir; Male; Prospective Studies; Pyrimidinones; Ritonavir; Triglycerides

2003
Lopinavir plasma concentrations and changes in lipid levels during salvage therapy with lopinavir/ritonavir-containing regimens.
    Journal of acquired immune deficiency syndromes (1999), 2003, Aug-15, Volume: 33, Issue:5

    Topics: Adult; Cholesterol; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Hyperlipidemias; Lipid Metabolism; Lipids; Lopinavir; Male; Prospective Studies; Pyrimidinones; Ritonavir; Time Factors; Triglycerides

2003
Virological success of lopinavir/ritonavir salvage regimen is affected by an increasing number of lopinavir/ritonavir-related mutations.
    Antiviral therapy, 2003, Volume: 8, Issue:3

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Resistance, Multiple, Viral; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Mutation; Proportional Hazards Models; Pyrimidinones; Ritonavir; Salvage Therapy; Viremia

2003
Interleukin-7 levels may predict virological response in advanced HIV-1-infected patients receiving lopinavir/ritonavir-based therapy.
    HIV medicine, 2003, Volume: 4, Issue:4

    Topics: Adult; Anti-HIV Agents; Female; HIV Infections; Humans; Interleukin-7; Lopinavir; Lymphocyte Count; Male; Prospective Studies; Pyrimidinones; Ritonavir; T-Lymphocytes; Viral Load

2003
Meeting notes from the 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment. Atazanavir in treatment-experienced patients.
    AIDS clinical care, 2003, Volume: 15, Issue:9

    Topics: Anti-HIV Agents; Atazanavir Sulfate; CD4 Lymphocyte Count; Drug Therapy, Combination; HIV Infections; Humans; Lopinavir; Oligopeptides; Pyridines; Pyrimidinones; Ritonavir; Viral Load

2003
Incidence of resistance in a double-blind study comparing lopinavir/ritonavir plus stavudine and lamivudine to nelfinavir plus stavudine and lamivudine.
    The Journal of infectious diseases, 2004, Jan-01, Volume: 189, Issue:1

    Topics: Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Global Health; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Mutation; Nelfinavir; Patient Compliance; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Stavudine; Time Factors; Viral Load

2004
Once-daily versus twice-daily lopinavir/ritonavir in antiretroviral-naive HIV-positive patients: a 48-week randomized clinical trial.
    The Journal of infectious diseases, 2004, Jan-15, Volume: 189, Issue:2

    Topics: Adult; Aged; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Patient Compliance; Pyrimidinones; Ritonavir

2004
Differential diffusions of indinavir and lopinavir in genital secretions of human immunodeficiency virus-infected women.
    Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:2

    Topics: Adult; Anti-HIV Agents; Chromatography, High Pressure Liquid; Female; Genitalia, Female; HIV Infections; HIV-1; Humans; Indinavir; Lopinavir; Protein Binding; Pyrimidinones; Vagina

2004
Lopinavir protein binding in vivo through the 12-hour dosing interval.
    Therapeutic drug monitoring, 2004, Volume: 26, Issue:1

    Topics: Adult; Area Under Curve; Blood Proteins; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Protein Binding; Pyrimidinones; Ritonavir; Ultrafiltration

2004
Impact of drug levels and baseline genotype and phenotype on the virologic response to amprenavir/ritonavir-based salvage regimens.
    AIDS patient care and STDs, 2004, Volume: 18, Issue:1

    Topics: Adult; Antiretroviral Therapy, Highly Active; Area Under Curve; Carbamates; CD4 Lymphocyte Count; Drug Administration Schedule; Drug Resistance, Viral; Female; Furans; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Mutation; Patient Selection; Phenotype; Predictive Value of Tests; Prospective Studies; Pyrimidinones; Ritonavir; RNA, Viral; Salvage Therapy; Sulfonamides; Treatment Outcome; Viral Load

2004
Changes in body fat composition after 1 year of salvage therapy with lopinavir/ritonavir-containing regimens and its relationship with lopinavir plasma concentrations.
    Antiviral therapy, 2004, Volume: 9, Issue:1

    Topics: Adipose Tissue; Anti-HIV Agents; Area Under Curve; Body Composition; Body Mass Index; Body Weight; CD4 Lymphocyte Count; Follow-Up Studies; HIV Infections; Humans; Lopinavir; Prospective Studies; Pyrimidinones; Ritonavir; Salvage Therapy; Tomography, X-Ray Computed

2004
Safety, efficacy and development of resistance under the new protease inhibitor lopinavir/ritonavir: 48-week results.
    Infection, 2004, Volume: 32, Issue:2

    Topics: Adult; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Multiple, Viral; Female; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Microbial Sensitivity Tests; Middle Aged; Pharmacogenetics; Probability; Prospective Studies; Pyrimidinones; Risk Assessment; Ritonavir; RNA, Viral; Severity of Illness Index; Treatment Outcome; Viral Load

2004
Interactions between amprenavir and the lopinavir-ritonavir combination in heavily pretreated patients infected with human immunodeficiency virus.
    Clinical pharmacology and therapeutics, 2004, Volume: 75, Issue:4

    Topics: Administration, Oral; Adult; Antiretroviral Therapy, Highly Active; Biological Availability; Carbamates; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Female; Follow-Up Studies; Furans; HIV Infections; Humans; Lopinavir; Male; Maximum Tolerated Dose; Middle Aged; Probability; Pyrimidinones; Risk Assessment; Ritonavir; Salvage Therapy; Severity of Illness Index; Single-Blind Method; Statistics, Nonparametric; Sulfonamides; Survival Rate; Treatment Outcome; Viral Load

2004
Long-term safety and durable antiretroviral activity of lopinavir/ritonavir in treatment-naive patients: 4 year follow-up study.
    AIDS (London, England), 2004, Mar-26, Volume: 18, Issue:5

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Administration Schedule; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Lamivudine; Lopinavir; Male; Prospective Studies; Pyrimidinones; Ritonavir; RNA, Viral; Stavudine; Time Factors

2004
Lipid abnormalities in HIV-infected patients are not correlated with lopinavir plasma concentrations.
    Journal of acquired immune deficiency syndromes (1999), 2004, Mar-01, Volume: 35, Issue:3

    Topics: Adult; Anti-HIV Agents; Drug Administration Schedule; Drug Monitoring; Female; HIV Infections; Humans; Lipids; Lopinavir; Male; Metabolic Diseases; Pyrimidinones; Reproducibility of Results

2004
Deep salvage with amprenavir and lopinavir/ritonavir: correlation of pharmacokinetics and drug resistance with pharmacodynamics.
    Journal of acquired immune deficiency syndromes (1999), 2004, Apr-01, Volume: 35, Issue:4

    Topics: Adult; Anti-HIV Agents; Carbamates; CD4 Lymphocyte Count; Drug Resistance, Viral; Drug Therapy, Combination; Female; Furans; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pilot Projects; Pyrimidinones; Ritonavir; RNA, Viral; Salvage Therapy; Sulfonamides

2004
Safety and efficacy of a NRTI-sparing HAART regimen of efavirenz and lopinavir/ritonavir in HIV-1-infected children.
    Antiviral therapy, 2004, Volume: 9, Issue:2

    Topics: Adolescent; Alkynes; Antiretroviral Therapy, Highly Active; Benzoxazines; Child; Child, Preschool; Cyclopropanes; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Lopinavir; Oxazines; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Outcome

2004
Baseline HIV-1 RNA level and CD4 cell count predict time to loss of virologic response to nelfinavir, but not lopinavir/ritonavir, in antiretroviral therapy-naive patients.
    The Journal of infectious diseases, 2004, Jul-15, Volume: 190, Issue:2

    Topics: Anti-HIV Agents; CD4 Lymphocyte Count; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lamivudine; Lopinavir; Male; Nelfinavir; Predictive Value of Tests; Pyrimidinones; Risk Factors; Ritonavir; RNA, Viral; Sex Characteristics; Stavudine; Viral Load

2004
Coadministration of lopinavir/ritonavir and phenytoin results in two-way drug interaction through cytochrome P-450 induction.
    Journal of acquired immune deficiency syndromes (1999), 2004, Aug-15, Volume: 36, Issue:5

    Topics: Adult; Anticonvulsants; Cytochrome P-450 Enzyme System; Drug Interactions; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Pharmacogenetics; Phenytoin; Pyrimidinones; Ritonavir; Seizures

2004
Lopinavir/ritonavir combined with twice-daily 400 mg indinavir: pharmacokinetics and pharmacodynamics in blood, CSF and semen.
    The Journal of antimicrobial chemotherapy, 2004, Volume: 54, Issue:2

    Topics: Adult; Area Under Curve; CD4 Lymphocyte Count; Chromatography, High Pressure Liquid; Drug Combinations; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lopinavir; Male; Mass Spectrometry; Middle Aged; Pyrimidinones; RNA, Viral; Semen; Viral Load

2004
The NIQ of lopinavir is predictive of a 48-week virological response in highly treatment-experienced HIV-1-infected subjects treated with a lopinavir/ritonavir-containing regimen.
    Antiviral therapy, 2004, Volume: 9, Issue:4

    Topics: Adult; CD4 Lymphocyte Count; Drug Monitoring; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Microbial Sensitivity Tests; Multivariate Analysis; Phenotype; Pyrimidinones; Ritonavir; Viral Load

2004
Salvage therapy with amprenavir, lopinavir and ritonavir 200 mg/d or 400 mg/d in HIV-infected patients in virological failure.
    Antiviral therapy, 2004, Volume: 9, Issue:4

    Topics: Adult; Aged; Carbamates; Drug Administration Schedule; Drug Therapy, Combination; Female; France; Furans; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; RNA, Viral; Salvage Therapy; Sulfonamides; Viral Load

2004
Steady-state pharmacokinetics of a double-boosting regimen of saquinavir soft gel plus lopinavir plus minidose ritonavir in human immunodeficiency virus-infected adults.
    Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:11

    Topics: Adult; Area Under Curve; Body Weight; Capsules; Drug Therapy, Combination; Excipients; Female; Gelatin; Hepatitis, Chronic; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Pyrimidinones; Ritonavir; Saquinavir; Sex Characteristics; Treatment Failure; Viral Load

2004
A comparison of dyslipidemias associated with either lopinavir/ritonavir- or indinavir/ritonavir-based antiretroviral therapy.
    Journal of acquired immune deficiency syndromes (1999), 2004, Dec-15, Volume: 37, Issue:5

    Topics: Adult; CD4 Lymphocyte Count; Cholesterol; Cohort Studies; Drug Therapy, Combination; Dyslipidemias; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lopinavir; Pyrimidinones; Retrospective Studies; Ritonavir; Treatment Outcome; Triglycerides; Viral Load

2004
Salvage lopinavir-ritonavir therapy in human immunodeficiency virus-infected children.
    The Pediatric infectious disease journal, 2004, Volume: 23, Issue:10

    Topics: Amino Acid Sequence; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Child; Drug Resistance, Viral; Drug Therapy, Combination; Genes, Viral; Genotype; HIV Infections; HIV-1; Humans; Lopinavir; Mutation; Pyrimidinones; Ritonavir; Salvage Therapy; Viral Load

2004
Lopinavir/ritonavir plus nevirapine as a nucleoside-sparing approach in antiretroviral-experienced patients (NEKA study).
    Journal of acquired immune deficiency syndromes (1999), 2005, Jan-01, Volume: 38, Issue:1

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cholesterol, HDL; Cholesterol, LDL; Drug Tolerance; Female; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Lipids; Lopinavir; Male; Middle Aged; Mitochondria; Nevirapine; Prospective Studies; Pyrimidinones; Ritonavir; Safety

2005
Lopinavir plasma levels in salvage regimes by a population of highly active antiretroviral therapy-treated HIV-1-positive patients.
    AIDS patient care and STDs, 2004, Volume: 18, Issue:11

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Pyrimidinones; Salvage Therapy; Substance Abuse, Intravenous

2004
Tolerability of postexposure prophylaxis with the combination of zidovudine-lamivudine and lopinavir-ritonavir for HIV infection.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2005, Jan-15, Volume: 40, Issue:2

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Combinations; Female; HIV Infections; Humans; Lamivudine; Lopinavir; Male; Pyrimidinones; Ritonavir; Viral Load; Zidovudine

2005
Combining fosamprenavir with lopinavir/ritonavir substantially reduces amprenavir and lopinavir exposure: ACTG protocol A5143 results.
    AIDS (London, England), 2005, Jan-28, Volume: 19, Issue:2

    Topics: Adult; Carbamates; Drug Interactions; Drug Therapy, Combination; Female; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Organophosphates; Pyrimidinones; Ritonavir; Salvage Therapy; Sulfonamides; Treatment Outcome

2005
Boosted Reyataz comparable to Kaletra.
    AIDS patient care and STDs, 2005, Volume: 19, Issue:1

    Topics: Atazanavir Sulfate; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; HIV Infections; Humans; Lopinavir; Male; Maximum Tolerated Dose; Oligopeptides; Probability; Pyridines; Pyrimidinones; Risk Assessment; Severity of Illness Index; Treatment Outcome

2005
Selection of resistance in protease inhibitor-experienced, human immunodeficiency virus type 1-infected subjects failing lopinavir- and ritonavir-based therapy: mutation patterns and baseline correlates.
    Journal of virology, 2005, Volume: 79, Issue:6

    Topics: Amino Acid Substitution; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Microbial Sensitivity Tests; Mutation; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Sequence Analysis

2005
Early virological failure with a combination of tenofovir, didanosine and efavirenz.
    Antiviral therapy, 2005, Volume: 10, Issue:1

    Topics: Adenine; Adult; Aged; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Didanosine; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Mutation; Organophosphonates; Oxazines; Pyrimidinones; RNA, Viral; Tenofovir; Time Factors; Treatment Failure; Viremia

2005
Lipid disorders in antiretroviral-naive patients treated with lopinavir/ritonavir-based HAART: frequency, characterization and risk factors.
    The Journal of antimicrobial chemotherapy, 2005, Volume: 55, Issue:5

    Topics: Adult; Aged; Antiretroviral Therapy, Highly Active; Cholesterol, HDL; Cholesterol, LDL; Female; Hepatitis C; HIV Infections; HIV Protease Inhibitors; Humans; Hypercholesterolemia; Hyperlipidemias; Hypertriglyceridemia; Lipids; Lopinavir; Male; Middle Aged; Pyrimidinones; Risk Factors; Ritonavir; Triglycerides

2005
A population approach to study the influence of nevirapine administration on lopinavir pharmacokinetics in HIV-1 infected patients.
    European journal of clinical pharmacology, 2005, Volume: 61, Issue:2

    Topics: Adult; Anti-HIV Agents; Bayes Theorem; Drug Interactions; Female; HIV Infections; Humans; Lopinavir; Male; Nevirapine; Pyrimidinones; Reverse Transcriptase Inhibitors

2005
Cerebrospinal fluid and plasma HIV-1 RNA levels and lopinavir concentrations following lopinavir/ritonavir regimen.
    Scandinavian journal of infectious diseases, 2004, Volume: 36, Issue:11-12

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Neopterin; Pyrimidinones; Ritonavir; RNA, Viral; Viral Load

2004
Absence of circadian variation in the pharmacokinetics of lopinavir/ritonavir given as a once daily dosing regimen in HIV-1-infected patients.
    British journal of clinical pharmacology, 2005, Volume: 59, Issue:4

    Topics: Adult; Aged; Anti-HIV Agents; Area Under Curve; Cross-Over Studies; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir

2005
Lopinavir/r versus nelfinavir as salvage therapy.
    The Pediatric infectious disease journal, 2005, Volume: 24, Issue:4

    Topics: Child; Child, Preschool; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Infant; Lopinavir; Nelfinavir; Pyrimidinones; Reverse Transcriptase Inhibitors; Salvage Therapy; Viral Load

2005
Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing multiple virological failures.
    AIDS (London, England), 2005, Apr-29, Volume: 19, Issue:7

    Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; CD4 Lymphocyte Count; Cholesterol; Drug Administration Schedule; Drug Resistance, Multiple, Viral; HIV Infections; HIV-1; Humans; Lipids; Lopinavir; Oligopeptides; Organophosphonates; Pyridines; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Saquinavir; Tenofovir; Viral Load

2005
Virological and pharmacological parameters predicting the response to lopinavir-ritonavir in heavily protease inhibitor-experienced patients.
    Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:5

    Topics: Adult; Aged; Drug Combinations; Drug Monitoring; Female; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Linear Models; Lopinavir; Male; Middle Aged; Mutation; Predictive Value of Tests; Pyrimidinones; Ritonavir; RNA, Viral

2005
Relationship between adherence and the development of resistance in antiretroviral-naive, HIV-1-infected patients receiving lopinavir/ritonavir or nelfinavir.
    The Journal of infectious diseases, 2005, Jun-15, Volume: 191, Issue:12

    Topics: Double-Blind Method; Drug Resistance, Viral; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Nelfinavir; Odds Ratio; Patient Compliance; Pyrimidinones; Risk Factors; Ritonavir; RNA, Viral; Viral Load

2005
Immunological changes after highly active antiretroviral therapy with lopinavir-ritonavir in heavily pretreated HIV-infected children.
    AIDS research and human retroviruses, 2005, Volume: 21, Issue:5

    Topics: Adolescent; Antiretroviral Therapy, Highly Active; Child; Child, Preschool; Female; HIV Infections; HIV Protease Inhibitors; Humans; Immunologic Memory; Infant; Lopinavir; Male; Prospective Studies; Pyrimidinones; Ritonavir; Salvage Therapy; T-Lymphocyte Subsets; Thymus Gland; Treatment Outcome

2005
Efficacy and tolerability of a nucleoside reverse transcriptase inhibitor-sparing combination of lopinavir/ritonavir and efavirenz in HIV-1-infected patients.
    Journal of acquired immune deficiency syndromes (1999), 2005, Jul-01, Volume: 39, Issue:3

    Topics: Adolescent; Adult; Aged; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Drug Resistance, Viral; Drug Tolerance; Female; France; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Oxazines; Prospective Studies; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Safety

2005
Stavudine, lamivudine plus novel protease inhibitor therapy in antiretroviral-naive HIV-infected individuals treated for 24 weeks.
    Antiviral therapy, 1999, Volume: 4 Suppl 3

    Topics: Anti-HIV Agents; CD4 Lymphocyte Count; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Stavudine; Treatment Outcome; Viral Load

1999
Liver injury and changes in hepatitis C Virus (HCV) RNA load associated with protease inhibitor-based antiretroviral therapy for treatment-naive HCV-HIV-coinfected patients: lopinavir-ritonavir versus nelfinavir.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2005, Oct-15, Volume: 41, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Female; Hepacivirus; Hepatitis C; HIV Infections; Humans; Liver; Lopinavir; Male; Middle Aged; Nelfinavir; Pyrimidinones; Ritonavir; RNA, Viral; Viral Load

2005
A randomized trial to evaluate lopinavir/ritonavir versus saquinavir/ritonavir in HIV-1-infected patients: the MaxCmin2 trial.
    Antiviral therapy, 2005, Volume: 10, Issue:6

    Topics: Adult; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; Saquinavir; Treatment Outcome

2005
Safety and antiviral response at 12 months of lopinavir/ritonavir therapy in human immunodeficiency virus-1-infected children experienced with three classes of antiretrovirals.
    The Pediatric infectious disease journal, 2005, Volume: 24, Issue:10

    Topics: Adolescent; Anti-HIV Agents; Child; Child, Preschool; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Salvage Therapy; Treatment Outcome

2005
Pharmacokinetics and 24-week efficacy/safety of dual boosted saquinavir/lopinavir/ritonavir in nucleoside-pretreated children.
    The Pediatric infectious disease journal, 2005, Volume: 24, Issue:10

    Topics: Anti-HIV Agents; Child; Child, Preschool; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Saquinavir; Treatment Outcome

2005
Comparison of atazanavir with lopinavir/ritonavir in patients with prior protease inhibitor failure: a randomized multinational trial.
    Current medical research and opinion, 2005, Volume: 21, Issue:10

    Topics: Adult; Anti-HIV Agents; Atazanavir Sulfate; CD4 Lymphocyte Count; Cholesterol; Cholesterol, LDL; Female; HIV; HIV Infections; Humans; Lopinavir; Male; Oligopeptides; Protease Inhibitors; Pyridines; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Triglycerides

2005
Lopinavir/ritonavir as single-drug therapy for maintenance of HIV-1 viral suppression: 48-week results of a randomized, controlled, open-label, proof-of-concept pilot clinical trial (OK Study).
    Journal of acquired immune deficiency syndromes (1999), 2005, Nov-01, Volume: 40, Issue:3

    Topics: Adult; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Pilot Projects; Pyrimidinones; Ritonavir; RNA, Viral; Spain

2005
Prediction of early and confirmed virological response by genotypic inhibitory quotients for lopinavir in patients naïve for lopinavir with limited exposure to previous protease inhibitors.
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2006, Volume: 35, Issue:4

    Topics: Adult; Drug Resistance, Viral; Female; Genotype; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Logistic Models; Lopinavir; Male; Predictive Value of Tests; Pyrimidinones; RNA, Viral; Salvage Therapy

2006
Steady-state pharmacokinetics and tolerability of indinavir-lopinavir/r combination therapy in antiretroviral-experienced patients.
    Therapeutic drug monitoring, 2005, Volume: 27, Issue:6

    Topics: Adult; Area Under Curve; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Hypertriglyceridemia; Indinavir; Lopinavir; Male; Metabolic Clearance Rate; Pyrimidinones

2005
No significant influence of saquinavir hard-gel capsule administration on pharmacokinetics of lopinavir in combination with ritonavir: a population approach.
    Therapeutic drug monitoring, 2005, Volume: 27, Issue:6

    Topics: Administration, Oral; Adult; Bayes Theorem; Capsules; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Female; Gels; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Metabolic Clearance Rate; Pyrimidinones; Regression Analysis; Retrospective Studies; Ritonavir; Saquinavir

2005
Antiretroviral activity and safety of lopinavir/ritonavir in protease inhibitor-experienced HIV-infected children with severe-moderate immunodeficiency.
    The Journal of antimicrobial chemotherapy, 2006, Volume: 57, Issue:3

    Topics: Child; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir; Salvage Therapy

2006
Pharmacokinetics of lopinavir/ritonavir in HIV/hepatitis C virus-coinfected subjects with hepatic impairment.
    Journal of clinical pharmacology, 2006, Volume: 46, Issue:3

    Topics: Adult; Area Under Curve; Biological Availability; Drug Combinations; Drug Monitoring; Female; Hepatitis C; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Liver Diseases; Lopinavir; Male; Middle Aged; Pyrimidinones; Radioligand Assay; Ritonavir

2006
96-week comparison of once-daily atazanavir/ritonavir and twice-daily lopinavir/ritonavir in patients with multiple virologic failures.
    AIDS (London, England), 2006, Mar-21, Volume: 20, Issue:5

    Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Didanosine; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lipids; Lopinavir; Male; Oligopeptides; Organophosphonates; Pyridines; Pyrimidinones; Ritonavir; RNA, Viral; Saquinavir; Tenofovir; Time Factors; Treatment Outcome

2006
Increased antiretroviral potency by the addition of enfuvirtide to a four-drug regimen in antiretroviral-naive, HIV-infected patients.
    Antiviral therapy, 2006, Volume: 11, Issue:1

    Topics: Adenine; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Drug Synergism; Drug Therapy, Combination; Enfuvirtide; HIV Envelope Protein gp41; HIV Fusion Inhibitors; HIV Infections; Humans; Lamivudine; Lopinavir; Organophosphonates; Oxazines; Patient Compliance; Peptide Fragments; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome

2006
Ritonavir-boosted atazanavir-lopinavir combination: a pharmacokinetic interaction study of total, unbound plasma and cellular exposures.
    Antiviral therapy, 2006, Volume: 11, Issue:1

    Topics: Adult; Atazanavir Sulfate; Blood Proteins; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Oligopeptides; Protein Binding; Pyridines; Pyrimidinones; Ritonavir; Treatment Outcome

2006
Lopinavir/ritonavir exposure in treatment-naive HIV-infected children following twice or once daily administration.
    The Journal of antimicrobial chemotherapy, 2006, Volume: 57, Issue:6

    Topics: Adolescent; Anti-HIV Agents; Child; Child, Preschool; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Combination; Female; HIV Infections; Humans; Lopinavir; Male; Plasma; Pyrimidinones; Ritonavir

2006
Association of total bilirubin with indinavir and lopinavir plasma concentrations in HIV-infected patients receiving three different double-boosted dosing regimens.
    The Journal of antimicrobial chemotherapy, 2006, Volume: 58, Issue:2

    Topics: Adolescent; Adult; Anti-HIV Agents; Bilirubin; Chromatography, High Pressure Liquid; Drug Administration Schedule; Female; HIV Infections; Humans; Indinavir; Lopinavir; Male; Middle Aged; Multivariate Analysis; Pyrimidinones

2006
Pharmacokinetics of a once-daily regimen of lopinavir/ritonavir in HIV-1-infected children.
    Antiviral therapy, 2006, Volume: 11, Issue:4

    Topics: Anti-HIV Agents; Child; Child, Preschool; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Infant; Lamivudine; Lopinavir; Male; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Outcome; Zidovudine

2006
The KLEAN study of fosamprenavir-ritonavir versus lopinavir-ritonavir, each in combination with abacavir-lamivudine, for initial treatment of HIV infection over 48 weeks: a randomised non-inferiority trial.
    Lancet (London, England), 2006, Aug-05, Volume: 368, Issue:9534

    Topics: Carbamates; Dideoxynucleosides; Drug Therapy, Combination; Furans; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Organophosphates; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Sulfonamides

2006
A once-daily lopinavir/ritonavir-based regimen provides noninferior antiviral activity compared with a twice-daily regimen.
    Journal of acquired immune deficiency syndromes (1999), 2006, Oct-01, Volume: 43, Issue:2

    Topics: Adult; Antiretroviral Therapy, Highly Active; Drug Administration Schedule; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Pyrimidinones; Ritonavir; Safety

2006
The LOPSAQ study: 48 week analysis of a boosted double protease inhibitor regimen containing lopinavir/ritonavir plus saquinavir without additional antiretroviral therapy.
    The Journal of antimicrobial chemotherapy, 2006, Volume: 58, Issue:5

    Topics: Adult; Aged; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cohort Studies; Drug Interactions; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; Salvage Therapy; Saquinavir; Viral Load

2006
[Pharmacoeconomic analysis of a maintenance strategy with lopinavir/ritonavir monotherapy in HIV-infected patients].
    Enfermedades infecciosas y microbiologia clinica, 2006, Volume: 24, Issue:8

    Topics: Adult; Cost-Benefit Analysis; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir

2006
Reduced lopinavir exposure during pregnancy.
    AIDS (London, England), 2006, Oct-03, Volume: 20, Issue:15

    Topics: Adolescent; Adult; Area Under Curve; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Fetal Blood; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Postpartum Period; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, Third; Prospective Studies; Puerperal Infection; Pyrimidinones; Ritonavir

2006
Renal function in patients receiving tenofovir with ritonavir/lopinavir or ritonavir/atazanavir in the HIV Outpatient Study (HOPS) cohort.
    Journal of acquired immune deficiency syndromes (1999), 2006, Dec-15, Volume: 43, Issue:5

    Topics: Adenine; Adult; Atazanavir Sulfate; Cohort Studies; Female; HIV Infections; Humans; Kidney; Lopinavir; Male; Oligopeptides; Organophosphonates; Pyridines; Pyrimidinones; Ritonavir; Tenofovir

2006
Salvage therapy with amprenavir, lopinavir and ritonavir is durably potent in HIV-infected patients in virological failure: 1-year results.
    AIDS (London, England), 2007, Jan-11, Volume: 21, Issue:2

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Carbamates; Drug Resistance, Multiple, Viral; Follow-Up Studies; Furans; HIV Infections; HIV-1; Humans; Lopinavir; Pyrimidinones; Ritonavir; Salvage Therapy; Sulfonamides

2007
Randomized open-label trial of two simplified, class-sparing regimens following a first suppressive three or four-drug regimen.
    AIDS (London, England), 2007, Jan-30, Volume: 21, Issue:3

    Topics: Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Drug Resistance, Viral; Female; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Outcome

2007
Treatment outcomes amongst previously antiretroviral-naïve HIV-infected patients starting lopinavir/ritonavir-containing antiretroviral regimens at the Royal Free Hospital.
    HIV medicine, 2007, Volume: 8, Issue:1

    Topics: Adult; CD4 Lymphocyte Count; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; London; Lopinavir; Male; Pyrimidinones; Ritonavir; Treatment Outcome; Viral Load

2007
Exploratory study comparing the metabolic toxicities of a lopinavir/ritonavir plus saquinavir dual protease inhibitor regimen versus a lopinavir/ritonavir plus zidovudine/lamivudine nucleoside regimen.
    The Journal of antimicrobial chemotherapy, 2007, Volume: 59, Issue:5

    Topics: Adult; Anti-HIV Agents; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; Saquinavir; Zidovudine

2007
A computer-based system to aid in the interpretation of plasma concentrations of antiretrovirals for therapeutic drug monitoring.
    Antiviral therapy, 2007, Volume: 12, Issue:1

    Topics: Adult; Algorithms; Alkynes; Anti-Retroviral Agents; Artificial Intelligence; Bayes Theorem; Benzoxazines; California; Computer Systems; Cyclopropanes; Drug Monitoring; Drug Therapy, Combination; Expert Systems; Female; Fuzzy Logic; HIV Infections; Humans; Lopinavir; Male; Models, Biological; Practice Guidelines as Topic; Prospective Studies; Pyrimidinones; Reproducibility of Results

2007
Switching to a protease inhibitor-containing, nucleoside-sparing regimen (lopinavir/ritonavir plus efavirenz) increases limb fat but raises serum lipid levels: results of a prospective randomized trial (AIDS clinical trial group 5125s).
    Journal of acquired immune deficiency syndromes (1999), 2007, Jun-01, Volume: 45, Issue:2

    Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Body Fat Distribution; Cyclopropanes; Female; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Lopinavir; Male; Pyrimidinones; Ritonavir; Time Factors

2007
Predictive genotypic algorithm for virologic response to lopinavir-ritonavir in protease inhibitor-experienced patients.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:9

    Topics: Adult; Algorithms; Analysis of Variance; Cohort Studies; Female; Genotype; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Logistic Models; Lopinavir; Male; Middle Aged; Mutation; Pyrimidinones; Retrospective Studies; Ritonavir; RNA, Viral

2007
The effect of lopinavir/ritonavir on the renal clearance of tenofovir in HIV-infected patients.
    Clinical pharmacology and therapeutics, 2008, Volume: 83, Issue:2

    Topics: Adenine; Administration, Oral; Adult; Antiretroviral Therapy, Highly Active; Case-Control Studies; Drug Interactions; Female; Genotype; HIV Infections; HIV Protease Inhibitors; Humans; Kidney; Lopinavir; Male; Membrane Transport Proteins; Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Treatment Outcome

2008
Lopinavir/Ritonavir pharmacokinetic profile: impact of sex and other covariates following a change from twice-daily to once-daily therapy.
    Journal of clinical pharmacology, 2007, Volume: 47, Issue:8

    Topics: Adenine; Adult; Area Under Curve; Capsules; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Combinations; Drug Interactions; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Sex Factors; Tenofovir

2007
Efficacy and safety of darunavir-ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: a randomised controlled phase III trial.
    Lancet (London, England), 2007, Jul-07, Volume: 370, Issue:9581

    Topics: Adult; Antiretroviral Therapy, Highly Active; Darunavir; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; RNA, Viral; Sulfonamides

2007
Abacavir plasma pharmacokinetics in the absence and presence of atazanavir/ritonavir or lopinavir/ritonavir and vice versa in HIV-infected patients.
    Antiviral therapy, 2007, Volume: 12, Issue:5

    Topics: Adult; Area Under Curve; Atazanavir Sulfate; Dideoxynucleosides; Drug Administration Schedule; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Oligopeptides; Pyridines; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir

2007
Pharmacokinetics of two randomized trials evaluating the safety and efficacy of indinavir, saquinavir and lopinavir in combination with low-dose ritonavir: the MaxCmin1 and 2 trials.
    Basic & clinical pharmacology & toxicology, 2007, Volume: 101, Issue:5

    Topics: Adult; Double-Blind Method; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; Saquinavir; Treatment Failure

2007
Effect of highly active antiretroviral therapy on tacrolimus pharmacokinetics in hepatitis C virus and HIV co-infected liver transplant recipients in the ANRS HC-08 study.
    Clinical pharmacokinetics, 2007, Volume: 46, Issue:11

    Topics: Adult; Aged; Alkynes; Antiretroviral Therapy, Highly Active; Area Under Curve; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Dose-Response Relationship, Drug; Female; Graft Rejection; Half-Life; Hepatitis C; HIV; HIV Infections; Humans; Liver Transplantation; Lopinavir; Male; Middle Aged; Nelfinavir; Pyrimidinones; Ritonavir; Tacrolimus; Viral Load

2007
Amprenavir and lopinavir pharmacokinetics following coadministration of amprenavir or fosamprenavir with lopinavir/ritonavir, with or without efavirenz.
    Antiviral therapy, 2007, Volume: 12, Issue:6

    Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Carbamates; Cyclopropanes; Drug Interactions; Drug Therapy, Combination; Female; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Organophosphates; Pyrimidinones; Ritonavir; Sulfonamides

2007
Efficacy and safety of replacing lopinavir with atazanavir in HIV-infected patients with undetectable plasma viraemia: final results of the SLOAT trial.
    The Journal of antimicrobial chemotherapy, 2008, Volume: 61, Issue:1

    Topics: Adult; Aged; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Blood Glucose; CD4 Lymphocyte Count; Drug Administration Schedule; Female; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lipids; Lopinavir; Male; Middle Aged; Oligopeptides; Prospective Studies; Pyridines; Pyrimidinones; RNA, Viral; Treatment Outcome

2008
Lopinavir-ritonavir monotherapy versus lopinavir-ritonavir and two nucleosides for maintenance therapy of HIV.
    AIDS (London, England), 2008, Jan-11, Volume: 22, Issue:2

    Topics: Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Administration Schedule; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Nucleosides; Pyrimidinones; Ritonavir; RNA, Viral; Spain; Treatment Outcome; Viral Load

2008
Zidovudine/lamivudine contributes to insulin resistance within 3 months of starting combination antiretroviral therapy.
    AIDS (London, England), 2008, Jan-11, Volume: 22, Issue:2

    Topics: Adiponectin; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Body Composition; Glucose; Glycerol; HIV Infections; HIV-1; HIV-Associated Lipodystrophy Syndrome; Humans; Hyperinsulinism; Insulin Resistance; Lamivudine; Lipid Metabolism; Lipids; Lopinavir; Male; Middle Aged; Pyrimidinones; Time Factors; Treatment Outcome; Zidovudine

2008
Pharmacokinetics, safety and efficacy of lopinavir/ritonavir in infants less than 6 months of age: 24 week results.
    AIDS (London, England), 2008, Jan-11, Volume: 22, Issue:2

    Topics: Antiretroviral Therapy, Highly Active; Brazil; CD4 Lymphocyte Count; Child, Preschool; Drug Administration Schedule; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Infant; Lopinavir; Male; Prospective Studies; Pyrimidinones; Ritonavir; Treatment Outcome; United States

2008
A lopinavir/ritonavir-based once-daily regimen results in better compliance and is non-inferior to a twice-daily regimen through 96 weeks.
    AIDS research and human retroviruses, 2007, Volume: 23, Issue:12

    Topics: Adult; Aged; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Patient Compliance; Pyrimidinones; Ritonavir; Viral Load

2007
Effect of an antiretroviral regimen containing ritonavir boosted lopinavir on intestinal and hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected patients.
    Clinical pharmacology and therapeutics, 2008, Volume: 84, Issue:1

    Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Drug Synergism; Female; HIV Infections; HIV Protease Inhibitors; Humans; Intestinal Mucosa; Intestines; Liver; Lopinavir; Male; Middle Aged; Prospective Studies; Pyrimidinones; Ritonavir

2008
Decreased adherence to antiretroviral therapy observed prior to transient human immunodeficiency virus type 1 viremia.
    The Journal of infectious diseases, 2007, Dec-15, Volume: 196, Issue:12

    Topics: Adult; Aged; Drug Administration Schedule; Drug Resistance, Multiple, Viral; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Prospective Studies; Pyrimidinones; Ritonavir; RNA, Viral; Treatment Refusal; Viral Load; Viremia

2007
Induction therapy with trizivir plus efavirenz or lopinavir/ritonavir followed by trizivir alone in naive HIV-1-infected adults.
    AIDS (London, England), 2008, Jan-30, Volume: 22, Issue:3

    Topics: Adult; Aged; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Dideoxynucleosides; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Failure; Treatment Outcome; Zidovudine

2008
Lopinavir/ritonavir monotherapy or plus zidovudine and lamivudine in antiretroviral-naive HIV-infected patients.
    AIDS (London, England), 2008, Jan-30, Volume: 22, Issue:3

    Topics: Adult; Anti-HIV Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV Infections; HIV Protease; HIV-1; Humans; Lamivudine; Lopinavir; Male; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Treatment Outcome; Viral Load; Zidovudine

2008
Predictive values of the human immunodeficiency virus phenotype and genotype and of amprenavir and lopinavir inhibitory quotients in heavily pretreated patients on a ritonavir-boosted dual-protease-inhibitor regimen.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5

    Topics: Adult; Aged; Carbamates; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; France; Furans; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Phenotype; Prognosis; Pyrimidinones; Ritonavir; RNA, Viral; Sulfonamides; Treatment Outcome; Viral Load

2008
Saquinavir plus lopinavir/ritonavir versus amprenavir plus lopinavir/ritonavir for treating highly resistant patients in Brazil.
    Journal of acquired immune deficiency syndromes (1999), 2008, Apr-01, Volume: 47, Issue:4

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Brazil; Carbamates; CD4 Lymphocyte Count; Drug Resistance, Viral; Drug Therapy, Combination; Female; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Pilot Projects; Prospective Studies; Pyrimidinones; Ritonavir; Saquinavir; Sulfonamides; Treatment Outcome

2008
Long-term (4 years) efficacy of lopinavir/ritonavir monotherapy for maintenance of HIV suppression.
    The Journal of antimicrobial chemotherapy, 2008, Volume: 61, Issue:6

    Topics: Adult; Drug Resistance, Viral; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Longitudinal Studies; Lopinavir; Male; Mutation; Pyrimidinones; Ritonavir; RNA, Viral; Treatment Outcome; Viral Load

2008
Absence of HIV-1 shedding in male genital tract after 1 year of first-line lopinavir/ritonavir alone or in combination with zidovudine/lamivudine.
    The Journal of antimicrobial chemotherapy, 2008, Volume: 61, Issue:6

    Topics: Anti-HIV Agents; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Genitalia, Male; HIV Infections; HIV-1; Humans; Lamivudine; Longitudinal Studies; Lopinavir; Male; Plasma; Pyrimidinones; Ritonavir; RNA, Viral; Semen; Time Factors; Virus Shedding; Zidovudine

2008
First-line antiretroviral therapy with efavirenz or lopinavir/ritonavir plus two nucleoside analogues: the SUSKA study, a non-randomized comparison from the VACH cohort.
    The Journal of antimicrobial chemotherapy, 2008, Volume: 61, Issue:6

    Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Female; HIV Infections; HIV-1; Humans; Hypertriglyceridemia; Kaplan-Meier Estimate; Longitudinal Studies; Lopinavir; Male; Pyrimidinones; Retrospective Studies; Ritonavir; RNA, Viral; Treatment Outcome; Viral Load; Withholding Treatment

2008
Similar efficacy of lopinavir/ritonavir-containing regimens among clades B and F HIV-1-Infected individuals in Brazil.
    Journal of acquired immune deficiency syndromes (1999), 2008, Mar-01, Volume: 47, Issue:3

    Topics: Brazil; CD4 Lymphocyte Count; Drug Combinations; Drug Resistance, Multiple; Drug Resistance, Viral; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Mutation; Prospective Studies; Pyrimidinones; Ritonavir; RNA, Viral; Time; Time Factors; Treatment Outcome

2008
An open-label pilot study to determine the efficacy of lopinavir/ritonavir and tenofovir DF in the treatment of HIV-infected patients experiencing first virologic failure on a non-nucleoside-based regimen.
    AIDS patient care and STDs, 2008, Volume: 22, Issue:4

    Topics: Adenine; Adult; Anti-HIV Agents; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Lopinavir; Middle Aged; Organophosphonates; Pilot Projects; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome

2008
CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels.
    European journal of clinical pharmacology, 2008, Volume: 64, Issue:8

    Topics: Adult; Aged; Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Cytochrome P-450 CYP3A; Drug Therapy, Combination; Enzyme Induction; Enzyme Inhibitors; Female; HIV Infections; HIV Protease Inhibitors; Humans; Hydroxycholesterols; Lopinavir; Male; Middle Aged; Oligopeptides; Pyridines; Pyrimidinones; Ritonavir; Young Adult

2008
Class-sparing regimens for initial treatment of HIV-1 infection.
    The New England journal of medicine, 2008, May-15, Volume: 358, Issue:20

    Topics: Adolescent; Adult; Alkynes; Benzoxazines; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Kaplan-Meier Estimate; Lopinavir; Male; Middle Aged; Mutation; Prospective Studies; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Treatment Failure

2008
ABT-378/ritonavir plus stavudine and lamivudine for the treatment of antiretroviral-naive adults with HIV-1 infection: 48-week results.
    AIDS (London, England), 2001, Jan-05, Volume: 15, Issue:1

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Male; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Stavudine; Viral Load

2001
Preliminary pharmacokinetic data on ABT-378 encouraging.
    AIDS patient care and STDs, 1998, Volume: 12, Issue:2

    Topics: Anti-HIV Agents; Drug Therapy, Combination; Drugs, Investigational; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pyrimidinones; Ritonavir

1998
Safety and antiviral activity at 48 weeks of lopinavir/ritonavir plus nevirapine and 2 nucleoside reverse-transcriptase inhibitors in human immunodeficiency virus type 1-infected protease inhibitor-experienced patients.
    The Journal of infectious diseases, 2002, Mar-01, Volume: 185, Issue:5

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Double-Blind Method; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Nevirapine; Prospective Studies; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Treatment Outcome

2002
Absence of opioid withdrawal symptoms in patients receiving methadone and the protease inhibitor lopinavir-ritonavir.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2002, Apr-15, Volume: 34, Issue:8

    Topics: Adult; Analgesics, Opioid; Drug Interactions; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Methadone; Opioid-Related Disorders; Pyrimidinones; Ritonavir; RNA, Viral; Substance Withdrawal Syndrome

2002
Lopinavir-ritonavir versus nelfinavir for the initial treatment of HIV infection.
    The New England journal of medicine, 2002, Jun-27, Volume: 346, Issue:26

    Topics: Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Double-Blind Method; Drug Resistance, Viral; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Nelfinavir; Proportional Hazards Models; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Stavudine; Survival Analysis; Viral Load

2002

Other Studies

769 other study(ies) available for lopinavir and HIV Coinfection

ArticleYear
Identification and structural characterization of I84C and I84A mutations that are associated with high-level resistance to human immunodeficiency virus protease inhibitors and impair viral replication.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:2

    Topics: Anti-HIV Agents; Atazanavir Sulfate; Drug Resistance, Viral; Genes, gag; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Mutation; Nelfinavir; Oligopeptides; Pyridines; Ritonavir; Saquinavir; Virus Replication

2007
A novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI), GRL-98065, is potent against multiple-PI-resistant human immunodeficiency virus in vitro.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6

    Topics: Amino Acid Sequence; Drug Design; Drug Resistance, Multiple, Viral; Furans; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Inhibitory Concentration 50; Microbial Sensitivity Tests; Models, Molecular; Molecular Sequence Data; Sulfonamides; Urethane; Virus Replication

2007
Decrease of atazanavir and lopinavir plasma concentrations in a boosted double human immunodeficiency virus protease inhibitor salvage regimen.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:6

    Topics: Atazanavir Sulfate; Drug Monitoring; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Oligopeptides; Pyridines; Pyrimidinones; Ritonavir; Salvage Therapy; Treatment Outcome

2008
Early postpartum pharmacokinetics of lopinavir initiated intrapartum in Thai women.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:5

    Topics: Adolescent; Adult; Area Under Curve; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Postpartum Period; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, Third; Pyrimidinones; Ritonavir; Thailand; Treatment Outcome; Young Adult

2009
Antiviral efficacy of the novel compound BIT225 against HIV-1 release from human macrophages.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:2

    Topics: Anti-HIV Agents; Blotting, Western; Cell Line; Cell Survival; Cells, Cultured; Drug Resistance, Viral; HIV Infections; HIV-1; HIV-2; Human Immunodeficiency Virus Proteins; Humans; Macrophages; Microscopy, Electron, Transmission; Molecular Structure; Polymerase Chain Reaction; Viral Regulatory and Accessory Proteins; Virion; Virus Release; Virus Replication

2010
Phenotypic susceptibility to bevirimat in isolates from HIV-1-infected patients without prior exposure to bevirimat.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:6

    Topics: Amino Acid Sequence; Amino Acid Substitution; Anti-HIV Agents; Base Sequence; DNA, Viral; Drug Resistance, Viral; gag Gene Products, Human Immunodeficiency Virus; Genes, gag; Genes, Viral; HIV Infections; HIV Protease; HIV-1; Humans; In Vitro Techniques; Microbial Sensitivity Tests; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenotype; Recombinant Proteins; Succinates; Triterpenes

2010
HIV-1 protease codon 36 polymorphisms and differential development of resistance to nelfinavir, lopinavir, and atazanavir in different HIV-1 subtypes.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:7

    Topics: Anti-HIV Agents; Atazanavir Sulfate; Cell Line; Cells, Cultured; Codon; Genotype; HIV Infections; HIV Protease; HIV-1; Humans; Lopinavir; Nelfinavir; Oligopeptides; Polymorphism, Genetic; Pyridines; Pyrimidinones

2010
Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease.
    Bioorganic & medicinal chemistry, 2013, Dec-01, Volume: 21, Issue:23

    Topics: Drug Resistance, Multiple; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Ligands; Models, Molecular; Protein Conformation

2013
Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants.
    Journal of medicinal chemistry, 2017, 05-25, Volume: 60, Issue:10

    Topics: Benzothiazoles; Crystallography, X-Ray; Drug Design; Drug Resistance, Multiple, Viral; Furans; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Ligands; Molecular Docking Simulation; Pyrans; Structure-Activity Relationship; Sulfonamides

2017
Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere.
    Journal of medicinal chemistry, 2020, 08-13, Volume: 63, Issue:15

    Topics: Crystallography, X-Ray; Darunavir; Dipeptides; Drug Design; Furans; HEK293 Cells; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Models, Molecular; Structure-Activity Relationship

2020
Drug interactions in HIV-infected children undergoing treatment with antiretrovirals.
    Andes pediatrica : revista Chilena de pediatria, 2021, Volume: 92, Issue:3

    Topics: Administration, Inhalation; Anti-HIV Agents; Anti-Inflammatory Agents; Child, Preschool; Drug Combinations; Drug Interactions; Fluticasone; HIV Infections; Humans; Lopinavir; Male; Rhinitis, Allergic; Ritonavir

2021
Comparing mutational pathways to lopinavir resistance in HIV-1 subtypes B versus C.
    PLoS computational biology, 2021, Volume: 17, Issue:9

    Topics: Bayes Theorem; Cohort Studies; Drug Resistance, Viral; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Mutation

2021
Comparative Bioavailability of Two Formulations of Biopharmaceutical Classification System (BCS) Class IV Drugs: A Case Study of Lopinavir/Ritonavir.
    Journal of pharmaceutical sciences, 2021, Volume: 110, Issue:12

    Topics: Animals; Anti-HIV Agents; Biological Availability; Biological Products; Dogs; Drug Combinations; HIV Infections; HIV Protease Inhibitors; Lopinavir; Ritonavir; Tablets

2021
Characterization of HIV-1 drug resistance among patients with failure of second-line combined antiretroviral therapy in central Ethiopia.
    HIV medicine, 2022, Volume: 23, Issue:2

    Topics: Adult; Anti-HIV Agents; Drug Resistance, Viral; Ethiopia; HIV Infections; HIV-1; Humans; Lamivudine; Lopinavir; Male; Ritonavir; Viral Load

2022
Physiologically Based Pharmacokinetic Modeling of 3 HIV Drugs in Combination and the Role of Lymphatic System after Subcutaneous Dosing. Part 1: Model for the Free-Drug Mixture.
    Journal of pharmaceutical sciences, 2022, Volume: 111, Issue:2

    Topics: Animals; HIV Infections; Lopinavir; Lymphatic System; Ritonavir; Tenofovir

2022
Physiologically Based Pharmacokinetic Modeling of 3 HIV Drugs in Combination and the Role of Lymphatic System after Subcutaneous Dosing. Part 2: Model for the Drug-combination Nanoparticles.
    Journal of pharmaceutical sciences, 2022, Volume: 111, Issue:3

    Topics: Drug Combinations; HIV Infections; Humans; Lopinavir; Lymphatic System; Models, Biological; Nanoparticles; Tenofovir

2022
The administration of lopinavir/ritonavir via an enteral feeding tube.
    Endocrinologia, diabetes y nutricion, 2021, Volume: 68, Issue:8

    Topics: Enteral Nutrition; HIV Infections; Humans; Lopinavir; Ritonavir

2021
Osteonecrosis of the humeral head in a human immunodeficiency virus-infected patient under tenofovir disoproxil fumarate-emtricitabine-lopinavir/ritonavir for 10 years: a case report.
    Journal of medical case reports, 2021, Dec-18, Volume: 15, Issue:1

    Topics: Emtricitabine; Female; HIV; HIV Infections; Humans; Humeral Head; Lopinavir; Middle Aged; Osteonecrosis; Ritonavir; Tenofovir

2021
Comparison of the Ivermectin and Lopinavir/Ritonavir Treatment Outcomes among COVID-19 Mild to Moderate Cases in Kaduna State.
    West African journal of medicine, 2022, Feb-28, Volume: 39, Issue:2

    Topics: COVID-19 Drug Treatment; Cross-Sectional Studies; HIV Infections; Humans; Ivermectin; Lopinavir; Nigeria; Ritonavir; SARS-CoV-2; Treatment Outcome

2022
HIV protease inhibitors Nelfinavir and Lopinavir/Ritonavir markedly improve lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect.
    Antiviral research, 2022, Volume: 202

    Topics: Animals; COVID-19 Drug Treatment; Cricetinae; HIV Infections; HIV Protease Inhibitors; Lopinavir; Lung; Mesocricetus; Nelfinavir; Ritonavir; RNA, Viral; SARS-CoV-2

2022
Slower Recovery with Early Lopinavir/Ritonavir use in Pediatric COVID-19 Patients: A Retrospective Observational Study.
    Paediatric drugs, 2022, Volume: 24, Issue:3

    Topics: Child; COVID-19; COVID-19 Drug Treatment; HIV Infections; Humans; Lopinavir; Ritonavir; Systemic Inflammatory Response Syndrome

2022
Darunavir-cobicistat versus lopinavir-ritonavir in the treatment of COVID-19 infection (DOLCI): A multicenter observational study.
    PloS one, 2022, Volume: 17, Issue:5

    Topics: Adult; Cobicistat; COVID-19 Drug Treatment; Darunavir; Drug Combinations; Drug Therapy, Combination; Female; HIV Infections; Humans; Lopinavir; Male; Retrospective Studies; Ritonavir; Treatment Outcome

2022
Quality of life and associated factors among people receiving second-line anti-retroviral therapy in Johannesburg, South Africa.
    BMC infectious diseases, 2022, May-12, Volume: 22, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Darunavir; Female; HIV Infections; HIV-1; Humans; Lopinavir; Quality of Life; Ritonavir; South Africa

2022
Long-acting HIV fusion inhibitor albuvirtide combined with ritonavir-boosted lopinavir for HIV-1-infected patients after failing the first-line antiretroviral therapy: 48-week randomized, controlled, phase 3 non-inferiority TALENT study.
    The Journal of infection, 2022, Volume: 85, Issue:3

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Therapy, Combination; HIV Fusion Inhibitors; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Maleimides; Peptides; Ritonavir; Viral Load

2022
A Comparative Analysis of Physiologically Based Pharmacokinetic Models for Human Immunodeficiency Virus and Tuberculosis Infections.
    Antimicrobial agents and chemotherapy, 2022, 09-20, Volume: 66, Issue:9

    Topics: Anti-Retroviral Agents; HIV; HIV Infections; Humans; Latent Tuberculosis; Lopinavir; Models, Biological; Rifampin; Ritonavir; Tuberculosis

2022
Menthol augmented niosomes for enhanced intestinal absorption of lopinavir.
    Pharmaceutical development and technology, 2022, Volume: 27, Issue:9

    Topics: Animals; HIV Infections; Intestinal Absorption; Liposomes; Lopinavir; Menthol; Particle Size; Rabbits

2022
Impact of Drug Exposure on Resistance Selection Following Artemether-Lumefantrine Treatment for Malaria in Children With and Without HIV in Uganda.
    Clinical pharmacology and therapeutics, 2023, Volume: 113, Issue:3

    Topics: Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Child; Drug Combinations; Fluorenes; HIV Infections; Humans; Lopinavir; Lumefantrine; Malaria; Malaria, Falciparum; Nevirapine; Ritonavir; Uganda

2023
Dose optimization with population pharmacokinetics of ritonavir-boosted lopinavir for Thai people living with HIV with and without active tuberculosis.
    Drug metabolism and pharmacokinetics, 2022, Volume: 47

    Topics: Anti-HIV Agents; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Rifampin; Ritonavir; Thailand; Tuberculosis

2022
Method validation and clinical application for the quantification of lopinavir, efavirenz, and ritonavir in breast milk using liquid chromatography tandem mass spectrometry.
    Journal of mass spectrometry : JMS, 2022, Volume: 57, Issue:12

    Topics: Anti-Retroviral Agents; Chromatography, Liquid; Female; HIV Infections; Humans; Lopinavir; Milk, Human; Ritonavir; Tandem Mass Spectrometry

2022
Virologic status and pattern of drug resistance mutation among ART-experienced HIV-infected patients in Butuo County, China.
    Journal of global antimicrobial resistance, 2023, Volume: 32

    Topics: Anti-HIV Agents; Cross-Sectional Studies; Emtricitabine; HIV Infections; Humans; Lamivudine; Lopinavir; Mutation; Nevirapine; Reverse Transcriptase Inhibitors

2023
Brief Report: Suboptimal Lopinavir Exposure in Infants on Rifampicin Treatment Receiving Double-dosed or Semisuperboosted Lopinavir/Ritonavir: Time for a Change.
    Journal of acquired immune deficiency syndromes (1999), 2023, 05-01, Volume: 93, Issue:1

    Topics: Anti-HIV Agents; Child; Female; HIV Infections; HIV Protease Inhibitors; Humans; Infant; Lopinavir; Male; Rifampin; Ritonavir

2023
Implications of the Digestion of Milk-Based Formulations for the Solubilization of Lopinavir/Ritonavir in a Combination Therapy.
    Molecular pharmaceutics, 2023, 04-03, Volume: 20, Issue:4

    Topics: Animals; Child; Digestion; Drug Combinations; Drug Therapy, Combination; HIV Infections; Humans; Infant; Lipids; Lopinavir; Milk; Ritonavir; Scattering, Small Angle; X-Ray Diffraction

2023
Causes of HIV Treatment Interruption during the Last 20 Years: A Multi-Cohort Real-Life Study.
    Viruses, 2023, 03-10, Volume: 15, Issue:3

    Topics: Anti-HIV Agents; Cohort Studies; HIV Infections; Humans; Lopinavir; Retrospective Studies; Rilpivirine

2023
Short-term toxicity assessment of combined use of zidovudine, lamivudine and lopinavir/ritonavir in vitro and in vivo.
    Basic & clinical pharmacology & toxicology, 2023, Volume: 133, Issue:1

    Topics: Animals; Anti-HIV Agents; Female; HIV Infections; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Male; Mammals; Mice; Rats; Ritonavir; Zidovudine

2023
Co-administration of rimonabant prevents glucose intolerance in Sprague-Dawley rats treated chronically with lopinavir/ritonavir and zidovudine: an experimental study design.
    The Pan African medical journal, 2023, Volume: 45

    Topics: Adult; Animals; Anti-HIV Agents; Cannabinoids; Glucose Intolerance; HIV Infections; Humans; Lopinavir; Male; Metabolic Syndrome; Rats; Rats, Sprague-Dawley; Rimonabant; Ritonavir; Zidovudine

2023
Optimizing antiretroviral therapy for children living with HIV: Experience from an observational cohort in Lesotho.
    PloS one, 2023, Volume: 18, Issue:7

    Topics: Anti-HIV Agents; Child; Child, Preschool; Female; HIV Infections; Humans; Infant; Lesotho; Lopinavir; Male; Nevirapine; Retrospective Studies; Ritonavir; Viral Load

2023
Inadequate Lopinavir Concentrations With Modified 8-Hourly Lopinavir/Ritonavir 4:1 Dosing During Rifampicin-based Tuberculosis Treatment in Children Living With HIV.
    The Pediatric infectious disease journal, 2023, 10-01, Volume: 42, Issue:10

    Topics: Anti-HIV Agents; Antitubercular Agents; Child; Child, Preschool; Drug Therapy, Combination; HIV Infections; Humans; Infant; Lopinavir; Rifampin; Ritonavir; Tuberculosis

2023
Population pharmacokinetic analysis of lopinavir in HIV negative individuals exposed to SARS-CoV-2: a COPEP (COronavirus Post-Exposure Prophylaxis) sub-study.
    BMC pharmacology & toxicology, 2023, 09-27, Volume: 24, Issue:1

    Topics: COVID-19; COVID-19 Drug Treatment; HIV Infections; Humans; Lopinavir; Post-Exposure Prophylaxis; SARS-CoV-2

2023
Evaluating pediatric tuberculosis dosing guidelines: A model-based individual data pooled analysis.
    PLoS medicine, 2023, Volume: 20, Issue:11

    Topics: Adolescent; Adult; Antitubercular Agents; Child; Child, Preschool; Female; HIV; HIV Infections; Humans; Infant; Infant, Newborn; Isoniazid; Lopinavir; Male; Pyrazinamide; Rifampin; Ritonavir; Tuberculosis

2023
A Comparative Study of Antiretroviral (Lopinavir/Ritonavir) and Remdesivir Used in the Pandemic in Iraq on the Clinical Outcome in Patients with SARS-CoV-2.
    Archives of Razi Institute, 2023, Volume: 78, Issue:3

    Topics: Aged; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; HIV Infections; Humans; Iraq; Lopinavir; Pandemics; Retrospective Studies; Ritonavir; SARS-CoV-2

2023
Population Pharmacokinetics of the Antituberculosis Agent Pretomanid.
    Antimicrobial agents and chemotherapy, 2019, Volume: 63, Issue:10

    Topics: Antitubercular Agents; Biological Availability; Clinical Trials as Topic; Extensively Drug-Resistant Tuberculosis; Female; HIV Infections; Humans; Lopinavir; Male; Nitroimidazoles; Rifampin; Ritonavir; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary

2019
Understanding acceptance of and adherence to a new formulation of paediatric antiretroviral treatment in the form of pellets (LPV/r)-A realist evaluation.
    PloS one, 2019, Volume: 14, Issue:8

    Topics: Anti-HIV Agents; Anti-Retroviral Agents; Caregivers; Child, Preschool; Drug Implants; Female; HIV Infections; Humans; Infant; Lopinavir; Male; Patient Acceptance of Health Care; Ritonavir; Viral Load

2019
Anti-HIV and Anti-Hepatitis C Virus Drugs Inhibit P-Glycoprotein Efflux Activity in Caco-2 Cells and Precision-Cut Rat and Human Intestinal Slices.
    Antimicrobial agents and chemotherapy, 2019, Volume: 63, Issue:11

    Topics: Aged; Animals; Anti-HIV Agents; Antiviral Agents; Atazanavir Sulfate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Caco-2 Cells; Carbamates; Drug Interactions; Female; Fluorenes; Hepatitis C; HIV Infections; Humans; Imidazoles; Intestines; Lopinavir; Male; Maraviroc; Middle Aged; Pyrrolidines; Rats; Rats, Wistar; Ritonavir; Saquinavir; Valine; Zidovudine

2019
Inflammatory biomarker levels over 48 weeks with dual vs triple lopinavir/ritonavir-based therapy: Substudy of a randomized trial.
    PloS one, 2019, Volume: 14, Issue:9

    Topics: Adult; Biomarkers; Female; HIV Infections; Humans; Inflammation; Lopinavir; Male; Middle Aged; Randomized Controlled Trials as Topic; Ritonavir; Time Factors; Treatment Outcome

2019
Lopinavir-Ritonavir Impairs Adrenal Function in Infants.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020, 08-14, Volume: 71, Issue:4

    Topics: Anti-HIV Agents; Burkina Faso; Child; Female; HIV Infections; Humans; Infant; Lopinavir; Pregnancy; Ritonavir; South Africa; Steroid 21-Hydroxylase

2020
Impact of Lopinavir/Ritonavir and Efavirenz-Based Antiretroviral Therapy on the Lipid Profile of Chinese HIV/AIDS Treatment-Naïve Patients in Beijing: A Retrospective Study.
    Current HIV research, 2019, Volume: 17, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Alkynes; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Asian People; Beijing; Benzoxazines; Case-Control Studies; Cyclopropanes; Drug-Related Side Effects and Adverse Reactions; Dyslipidemias; Female; HIV Infections; Hospitals, University; Humans; Lipids; Lopinavir; Male; Middle Aged; Retrospective Studies; Ritonavir; Treatment Outcome

2019
Physiologically-Based Pharmacokinetic Modeling for Optimal Dosage Prediction of Quinine Coadministered With Ritonavir-Boosted Lopinavir.
    Clinical pharmacology and therapeutics, 2020, Volume: 107, Issue:5

    Topics: Adolescent; Adult; Antimalarials; Coinfection; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Malaria; Middle Aged; Models, Biological; Quinine; Ritonavir; Young Adult

2020
Diverse Human Immunodeficiency Virus-1 Drug Resistance Profiles at Screening for ACTG A5288: A Study of People Experiencing Virologic Failure on Second-line Antiretroviral Therapy in Resource-limited Settings.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020, 10-23, Volume: 71, Issue:7

    Topics: Anti-HIV Agents; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Lopinavir; Reverse Transcriptase Inhibitors; Viral Load

2020
Pediatric Antiretroviral Therapeutic Drug Monitoring: A Five and a Half Year Experience from a South African Tertiary Hospital.
    Journal of tropical pediatrics, 2020, 08-01, Volume: 66, Issue:4

    Topics: Adolescent; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Child; Child, Preschool; Cyclopropanes; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Female; HIV Infections; Humans; Lopinavir; Male; Medication Adherence; Nevirapine; Pregnancy; Retrospective Studies; South Africa; Tertiary Care Centers; Treatment Outcome

2020
Genotypic resistance profiles of HIV-2-infected patients from Cape Verde failing first-line antiretroviral therapy.
    AIDS (London, England), 2020, 03-01, Volume: 34, Issue:3

    Topics: Anti-HIV Agents; Cabo Verde; Drug Resistance, Viral; HIV Infections; HIV Protease Inhibitors; HIV-1; HIV-2; Humans; Lamivudine; Lopinavir; Reverse Transcriptase Inhibitors; Ritonavir; Viral Load

2020
Descriptive analysis of World Health Organization-recommended second-line antiretroviral treatment: A retrospective cohort data analysis.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2019, Nov-27, Volume: 109, Issue:12

    Topics: Adult; Age Factors; CD4 Lymphocyte Count; Databases, Factual; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Lopinavir; Lost to Follow-Up; Male; Medication Adherence; Middle Aged; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Ritonavir; Sex Factors; Tenofovir; Treatment Failure; Viral Load; World Health Organization; Zidovudine

2019
Integration of Computational and Experimental Approaches to Elucidate Mechanisms of First-Pass Lymphatic Drug Sequestration and Long-Acting Pharmacokinetics of the Injectable Triple-HIV Drug Combination TLC-ART 101.
    Journal of pharmaceutical sciences, 2020, Volume: 109, Issue:5

    Topics: Animals; Anti-HIV Agents; Drug Combinations; HIV Infections; Lopinavir; Pharmaceutical Preparations; Ritonavir

2020
Brief Report: Sex Differences in Outcomes for Individuals Presenting for Third-Line Antiretroviral Therapy.
    Journal of acquired immune deficiency syndromes (1999), 2020, 06-01, Volume: 84, Issue:2

    Topics: Adult; Anti-HIV Agents; Cohort Studies; Developing Countries; Drug Combinations; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Reverse Transcriptase Inhibitors; Ritonavir; Sex Factors; Treatment Outcome

2020
Abacavir Exposure in Children Cotreated for Tuberculosis with Rifampin and Superboosted Lopinavir-Ritonavir.
    Antimicrobial agents and chemotherapy, 2020, 04-21, Volume: 64, Issue:5

    Topics: Anti-HIV Agents; Antitubercular Agents; Biological Availability; Child; Child, Preschool; Dideoxynucleosides; Drug Combinations; Drug Interactions; HIV Infections; Humans; Lopinavir; Prospective Studies; Rifampin; Ritonavir; Tuberculosis, Pulmonary

2020
Co-infection of SARS-CoV-2 and HIV in a patient in Wuhan city, China.
    Journal of medical virology, 2020, Volume: 92, Issue:6

    Topics: Anti-HIV Agents; Betacoronavirus; China; Clinical Laboratory Techniques; Coinfection; Coronavirus Infections; COVID-19; COVID-19 Testing; Diabetes Mellitus, Type 2; Drug Combinations; gamma-Globulins; HIV; HIV Infections; Humans; Lopinavir; Male; Methylprednisolone; Middle Aged; Moxifloxacin; Pandemics; Pneumonia, Viral; Ritonavir; SARS-CoV-2; Tomography, X-Ray Computed; Treatment Outcome

2020
Darunavir does not prevent SARS-CoV-2 infection in HIV patients.
    Pharmacological research, 2020, Volume: 157

    Topics: Betacoronavirus; Coronavirus Infections; COVID-19; Darunavir; HIV Infections; Humans; Lopinavir; Pandemics; Pneumonia, Viral; Republic of Korea; Reverse Transcriptase Polymerase Chain Reaction; Ritonavir; SARS-CoV-2

2020
Pyromellitic dianhydride crosslinked soluble cyclodextrin polymers: Synthesis, lopinavir release from sub-micron sized particles and anti-HIV-1 activity.
    International journal of pharmaceutics, 2020, Jun-15, Volume: 583

    Topics: Benzoates; Cell Line; Cell Survival; Cyclodextrins; Drug Liberation; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Solubility

2020
Drug level testing as a strategy to determine eligibility for drug resistance testing after failure of ART: a retrospective analysis of South African adult patients on second-line ART.
    Journal of the International AIDS Society, 2020, Volume: 23, Issue:6

    Topics: Adult; Drug Resistance, Viral; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Microbial Sensitivity Tests; Middle Aged; Retrospective Studies; Ritonavir; Treatment Failure; Viral Load

2020
Bone turnover markers in children living with HIV remaining on ritonavir-boosted lopinavir or switching to efavirenz.
    Bone, 2020, Volume: 138

    Topics: Alkynes; Benzoxazines; Bone Remodeling; Child; Cyclopropanes; HIV Infections; Humans; Lopinavir; Ritonavir

2020
Cases of coronavirus disease-2019 in HIV-infected transgender women.
    AIDS (London, England), 2020, 07-15, Volume: 34, Issue:9

    Topics: Adenine; Adult; Alanine; Anti-HIV Agents; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Dideoxynucleosides; Drug Combinations; Emtricitabine; Female; Heterocyclic Compounds, 3-Ring; Heterocyclic Compounds, 4 or More Rings; HIV Infections; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Oxazines; Pandemics; Piperazines; Pneumonia, Viral; Pyridones; Ritonavir; SARS-CoV-2; Tenofovir; Transgender Persons

2020
FGF21 and its Relationship with Inflammatory and Metabolic Parameters in HIV Patients after Antiretroviral Treatment.
    Current HIV research, 2020, Volume: 18, Issue:5

    Topics: Adult; Anti-Retroviral Agents; Atherosclerosis; Female; Fibroblast Growth Factors; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Inflammation; Inflammation Mediators; Lipid Metabolism; Lopinavir; Male; Metabolic Syndrome; Middle Aged; Prospective Studies; Risk Factors; Ritonavir; Tenofovir; Young Adult

2020
Periconceptional exposure to lopinavir, but not darunavir, impairs decidualization: a potential mechanism leading to poor birth outcomes in HIV-positive pregnancies.
    Human reproduction (Oxford, England), 2020, 08-01, Volume: 35, Issue:8

    Topics: Animals; Betacoronavirus; Cells, Cultured; Clinical Trials as Topic; Coculture Techniques; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Darunavir; Decidua; Disease Models, Animal; Drug Repositioning; Drug Therapy, Combination; Embryo Implantation; Endometrium; Female; HIV Infections; Humans; Lopinavir; Maternal Exposure; Mice; Pandemics; Placentation; Pneumonia, Viral; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, First; Primary Cell Culture; SARS-CoV-2; Trophoblasts; Vascular Remodeling

2020
Survival among antiretroviral-experienced HIV-2 patients experiencing virologic failure with drug resistance mutations in Cote d'Ivoire West Africa.
    PloS one, 2020, Volume: 15, Issue:8

    Topics: Adult; Anti-HIV Agents; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Cote d'Ivoire; Drug Resistance, Viral; Female; Genotype; HIV Infections; HIV Integrase Inhibitors; HIV-2; Humans; Lopinavir; Middle Aged; Mutation; Ritonavir; Viral Load

2020
Coronavirus disease 2019 in patients with HIV in the province of Araba, Basque Country, Spain.
    AIDS (London, England), 2020, 09-01, Volume: 34, Issue:11

    Topics: Adult; Aged; Anti-Retroviral Agents; Antiviral Agents; Betacoronavirus; CD4 Lymphocyte Count; Coinfection; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Female; Hepatitis C, Chronic; HIV Infections; Humans; Hydroxychloroquine; Interferon beta-1b; Lopinavir; Male; Middle Aged; Pandemics; Pneumonia, Viral; Protective Factors; Retrospective Studies; Risk Factors; SARS-CoV-2; Severity of Illness Index; Spain; Sustained Virologic Response; Viral Load

2020
Vitamin D Assessment Over 48 Weeks in Treatment-Naive HIV Individuals Starting Lopinavir/Ritonavir Monotherapy.
    Current HIV research, 2021, Volume: 19, Issue:1

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Pilot Projects; Protease Inhibitors; Ritonavir; Texas; Time Factors; Vitamin D Deficiency

2021
Prevalence and predictors of bone health among perinatally HIV-infected adolescents.
    AIDS (London, England), 2020, 11-15, Volume: 34, Issue:14

    Topics: Adolescent; Antiretroviral Therapy, Highly Active; Bone Density; Cross-Sectional Studies; Female; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Lopinavir; Male; Prevalence; Puberty; Ritonavir; Viral Load

2020
Effect of combination antiretroviral therapy on human immunodeficiency virus 1 specific antibody responses in subtype-C infected children.
    The Journal of general virology, 2020, Volume: 101, Issue:12

    Topics: Anti-HIV Agents; Antibodies, Neutralizing; Antibody-Dependent Cell Cytotoxicity; Antiretroviral Therapy, Highly Active; Child, Preschool; Cohort Studies; Dideoxynucleosides; Drug Combinations; HIV Antibodies; HIV Infections; HIV-1; Humans; Infant; Lamivudine; Lopinavir; Ritonavir; Viral Load; Zidovudine

2020
Effect of nevirapine, efavirenz and lopinavir/ritonavir on the therapeutic concentration and toxicity of lumefantrine in people living with HIV at Lagos University Teaching Hospital, Nigeria.
    Journal of pharmacological sciences, 2020, Volume: 144, Issue:3

    Topics: Adult; Alkynes; Anti-Retroviral Agents; Antimalarials; Artemether, Lumefantrine Drug Combination; Benzoxazines; Cyclopropanes; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; Humans; Lopinavir; Malaria; Male; Middle Aged; Nevirapine; Nigeria; Ritonavir; Treatment Outcome; Young Adult

2020
High levels of HIV drug resistance among adults failing second-line antiretroviral therapy in Namibia.
    Medicine, 2020, Sep-11, Volume: 99, Issue:37

    Topics: Adolescent; Adult; Anti-HIV Agents; Cross-Sectional Studies; Drug Resistance, Viral; Female; HIV; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Namibia; Prevalence; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Failure; Young Adult

2020
Suppression of HIV-1 Viral Replication by Inhibiting Drug Efflux Transporters in Activated Macrophages.
    Current HIV research, 2021, Volume: 19, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Cells, Cultured; Ethanol; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Macrophages; Male; Membrane Transport Proteins; Middle Aged; Virus Replication

2021
Rifabutin pharmacokinetics and safety among TB/HIV-coinfected children receiving lopinavir/ritonavir-containing second-line ART.
    The Journal of antimicrobial chemotherapy, 2021, 02-11, Volume: 76, Issue:3

    Topics: Adolescent; Adult; Child; Coinfection; HIV Infections; Humans; Lopinavir; Rifabutin; Ritonavir; Tuberculosis

2021
Antiretroviral drug activity and potential for pre-exposure prophylaxis against COVID-19 and HIV infection.
    Journal of biomolecular structure & dynamics, 2022, Volume: 40, Issue:16

    Topics: COVID-19; COVID-19 Drug Treatment; HIV Infections; Humans; Lopinavir; Pre-Exposure Prophylaxis; Ritonavir; RNA; RNA-Dependent RNA Polymerase; SARS-CoV-2

2022
Acquired HIV-1 Protease Conformational Flexibility Associated with Lopinavir Failure May Shape the Outcome of Darunavir Therapy after Antiretroviral Therapy Switch.
    Biomolecules, 2021, 03-24, Volume: 11, Issue:4

    Topics: Anti-Retroviral Agents; Darunavir; Drug Resistance, Viral; HIV Infections; HIV Protease; HIV-1; Humans; Hydrogen Bonding; Kinetics; Lopinavir; Molecular Dynamics Simulation; Mutation; Protein Stability; Recombinant Proteins; Thermodynamics; Treatment Failure

2021
Inhibition of CYP3A7 DHEA-S Oxidation by Lopinavir and Ritonavir: An Alternative Mechanism for Adrenal Impairment in HIV Antiretroviral-Treated Neonates.
    Chemical research in toxicology, 2021, 04-19, Volume: 34, Issue:4

    Topics: Adult; Anti-Retroviral Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dehydroepiandrosterone Sulfate; Drug Combinations; HIV Infections; HIV-1; Humans; Infant, Newborn; Lopinavir; Molecular Conformation; Oxidation-Reduction; Ritonavir

2021
Antiretroviral hair levels, self-reported adherence, and virologic failure in second-line regimen patients in resource-limited settings.
    AIDS (London, England), 2021, 07-15, Volume: 35, Issue:9

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Ritonavir; Self Report; Treatment Outcome; Viral Load

2021
Persistently lower bone mass and bone turnover among South African children living with well controlled HIV.
    AIDS (London, England), 2021, 11-01, Volume: 35, Issue:13

    Topics: Biomarkers; Bone Density; Bone Remodeling; Child; HIV Infections; Humans; Lopinavir; Ritonavir

2021
A Semimechanistic Pharmacokinetic Model for Depot Medroxyprogesterone Acetate and Drug-Drug Interactions With Antiretroviral and Antituberculosis Treatment.
    Clinical pharmacology and therapeutics, 2021, Volume: 110, Issue:4

    Topics: Alkynes; Anti-Retroviral Agents; Antitubercular Agents; Benzoxazines; Contraceptive Agents, Hormonal; Contraceptive Effectiveness; Cyclopropanes; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Delayed-Action Preparations; Drug Administration Schedule; Drug Combinations; Drug Interactions; Female; HIV Infections; Humans; Isoniazid; Lopinavir; Medroxyprogesterone Acetate; Nelfinavir; Rifampin; Ritonavir; Tuberculosis

2021
Point-of-Care Detection of Nonadherence to Antiretroviral Treatment for HIV-1 in Resource-Limited Settings Using Drug Level Testing for Efavirenz, Lopinavir, and Dolutegravir: A Validation and Pharmacokinetic Simulation Study.
    Journal of acquired immune deficiency syndromes (1999), 2021, 08-01, Volume: 87, Issue:4

    Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Heterocyclic Compounds, 3-Ring; HIV Infections; HIV-1; Humans; Immunoenzyme Techniques; Limit of Detection; Lopinavir; Medication Adherence; Oxazines; Piperazines; Point-of-Care Testing; Pyridones; Reproducibility of Results; Rural Population; South Africa

2021
Drug-induced liver injury associated with lopinavir-ritonavir in patients with COVID-19: a disproportionality analysis of U.S. food and drug administration adverse event reporting system (FAERS) data.
    International journal of clinical pharmacy, 2021, Volume: 43, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Aged; Anti-HIV Agents; Chemical and Drug Induced Liver Injury; COVID-19; Drug Combinations; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Ritonavir; United States; United States Food and Drug Administration

2021
Adoption of evidence-informed guidelines in prescribing protease inhibitors for HIV-Tuberculosis co-infected patients on rifampicin and effects on HIV treatment outcomes in Uganda.
    BMC infectious diseases, 2021, Aug-16, Volume: 21, Issue:1

    Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Coinfection; Drug Therapy, Combination; Female; Guidelines as Topic; HIV Infections; HIV Protease Inhibitors; Humans; Inappropriate Prescribing; Lopinavir; Middle Aged; Protease Inhibitors; Rifampin; Ritonavir; Treatment Outcome; Tuberculosis; Uganda; Young Adult

2021
Therapeutic drug monitoring of boosted PIs in HIV-positive patients: undetectable plasma concentrations and risk of virological failure.
    The Journal of antimicrobial chemotherapy, 2017, 06-01, Volume: 72, Issue:6

    Topics: Adult; Atazanavir Sulfate; Darunavir; Drug Monitoring; Drug Therapy, Combination; Female; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Medication Adherence; Middle Aged; Registries; Regression Analysis; Retrospective Studies; Ritonavir; RNA, Viral; Treatment Failure; Viral Load

2017
Impact of lopinavir-ritonavir exposure in HIV-1 infected children and adolescents in Madrid, Spain during 2000-2014.
    PloS one, 2017, Volume: 12, Issue:3

    Topics: Adolescent; CD4 Lymphocyte Count; CD4-CD8 Ratio; Child; Child, Preschool; Cohort Studies; Drug Combinations; Drug Resistance, Viral; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Host-Pathogen Interactions; Humans; Infant; Infant, Newborn; Lopinavir; Male; Mutation; Ritonavir; Spain; Treatment Outcome; Viral Load; Viremia

2017
Modelling CD4 T Cell Recovery in Hepatitis C and HIV Co-infected Children Receiving Antiretroviral Therapy.
    The Pediatric infectious disease journal, 2017, Volume: 36, Issue:5

    Topics: Antiretroviral Therapy, Highly Active; Antiviral Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Child; Child, Preschool; Cohort Studies; Coinfection; Drug Combinations; Female; Hepacivirus; Hepatitis C; HIV Infections; HIV-1; Humans; Interferon-alpha; Lamivudine; Lopinavir; Male; Models, Immunological; Polyethylene Glycols; Recombinant Proteins; Recovery of Function; Ribavirin; Ritonavir; Time-to-Treatment; Zidovudine

2017
Virological response and resistances over 12 months among HIV-infected children less than two years receiving first-line lopinavir/ritonavir-based antiretroviral therapy in Cote d'Ivoire and Burkina Faso: the MONOD ANRS 12206 cohort.
    Journal of the International AIDS Society, 2017, 04-25, Volume: 20, Issue:1

    Topics: Anti-HIV Agents; Drug Combinations; Drug Resistance, Viral; Female; HIV Infections; Humans; Infant; Lopinavir; Male; Prospective Studies; Ritonavir

2017
Sustained Viral Suppression in HIV-infected Children on Once-daily Lopinavir/Ritonavir in Clinical Practice.
    The Pediatric infectious disease journal, 2017, Volume: 36, Issue:10

    Topics: Adolescent; Anti-HIV Agents; Child; Child, Preschool; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Infant; Kaplan-Meier Estimate; Lopinavir; Male; Ritonavir; Sustained Virologic Response; Viral Load

2017
Assessing the Efficacy of Second-Line Antiretroviral Treatment for HIV Patients Failing First-Line Antiretroviral Therapy in Iran: A Cohort Study.
    Acta medica Iranica, 2017, Volume: 55, Issue:4

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cohort Studies; Drug Combinations; Female; HIV Infections; Humans; Iran; Longitudinal Studies; Lopinavir; Male; Ritonavir; Treatment Failure; Viral Load; Weight Gain

2017
Drug resistance testing through remote genotyping and predicted treatment options in human immunodeficiency virus type 1 infected Tanzanian subjects failing first or second line antiretroviral therapy.
    PloS one, 2017, Volume: 12, Issue:6

    Topics: Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Benzoxazines; Clinical Decision-Making; Computational Biology; Cross-Sectional Studies; Cyclopropanes; Drug Resistance, Viral; Emtricitabine; Female; Genotype; HIV Infections; HIV-1; Humans; Lamivudine; Lopinavir; Male; Monitoring, Physiologic; Nevirapine; pol Gene Products, Human Immunodeficiency Virus; Stavudine; Tanzania; Tenofovir; Treatment Failure; Viral Load

2017
Neurocognitive development in HIV-positive children is correlated with plasma viral loads in early childhood.
    Medicine, 2017, Volume: 96, Issue:23

    Topics: Adolescent; Anti-HIV Agents; Child; Child Development; Cognition; Cognition Disorders; Female; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Intelligence; Intelligence Tests; Lopinavir; Male; Neuropsychological Tests; Prospective Studies; Retrospective Studies; Ritonavir; Viral Load

2017
A retrospective case-cohort study comparing treatment outcomes in abacavir versus stavudine containing first line antiretroviral treatment regimens in children <3yrs old, at a paediatric programme based in Soweto, South Africa.
    PloS one, 2017, Volume: 12, Issue:7

    Topics: Child, Preschool; Dideoxynucleosides; Drug Combinations; Female; HIV; HIV Infections; Humans; Infant; Lamivudine; Lopinavir; Male; Retrospective Studies; Ritonavir; South Africa; Stavudine; Treatment Outcome; Viral Load

2017
Impact of Single Nucleotide Polymorphisms on Plasma Concentrations of Efavirenz and Lopinavir/Ritonavir in Chinese Children Infected with the Human Immunodeficiency Virus.
    Pharmacotherapy, 2017, Volume: 37, Issue:9

    Topics: Adolescent; Alkynes; Asian People; Benzoxazines; Child; Cohort Studies; Cross-Sectional Studies; Cyclopropanes; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Polymorphism, Single Nucleotide; Retrospective Studies; Ritonavir

2017
Brief Report: Lopinavir Hair Concentrations Are the Strongest Predictor of Viremia in HIV-Infected Asian Children and Adolescents on Second-Line Antiretroviral Therapy.
    Journal of acquired immune deficiency syndromes (1999), 2017, 12-01, Volume: 76, Issue:4

    Topics: Adolescent; Anti-HIV Agents; Asian People; CD4 Lymphocyte Count; Child; Drug Monitoring; Female; Hair; HIV Infections; Humans; Indonesia; Longitudinal Studies; Lopinavir; Male; Medication Adherence; Predictive Value of Tests; Thailand; Vietnam; Viral Load; Viremia

2017
Hepatic, Renal, Hematologic, and Inflammatory Markers in HIV-Infected Children on Long-term Suppressive Antiretroviral Therapy.
    Journal of the Pediatric Infectious Diseases Society, 2017, Sep-01, Volume: 6, Issue:3

    Topics: Adolescent; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Biomarkers; C-Reactive Protein; Child; Child, Preschool; Cholesterol; Creatinine; Cyclopropanes; Cystatin C; Drug Monitoring; Europe; Female; Fibrin Fibrinogen Degradation Products; HIV Infections; Humans; Inflammation; Interleukin-6; Kidney; Lipopolysaccharide Receptors; Liver; Lopinavir; Male; North America; Reverse Transcriptase Inhibitors; Ritonavir; Time Factors; Treatment Outcome

2017
Use of Adult Sensory Panel to Study Individual Differences in the Palatability of a Pediatric HIV Treatment Drug.
    Clinical therapeutics, 2017, Volume: 39, Issue:10

    Topics: Adult; Child; Drug Combinations; Female; Genotype; HIV Infections; Humans; Lopinavir; Middle Aged; Protease Inhibitors; Reproducibility of Results; Ritonavir; Taste; Young Adult

2017
Altered angiogenesis as a common mechanism underlying preterm birth, small for gestational age, and stillbirth in women living with HIV.
    American journal of obstetrics and gynecology, 2017, Volume: 217, Issue:6

    Topics: Adult; Alkynes; Angiopoietin-1; Angiopoietin-2; Anti-HIV Agents; Benzoxazines; Biomarkers; Cyclopropanes; Drug Combinations; Endoglin; Female; HIV Infections; Humans; Infant, Newborn; Infant, Small for Gestational Age; Lopinavir; Neovascularization, Physiologic; Placenta Growth Factor; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Premature Birth; Ritonavir; Stillbirth; Uganda; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1

2017
Pharmacogenetics-based population pharmacokinetic analysis of tenofovir in Thai HIV-infected patients.
    Pharmacogenomics, 2017, Volume: 18, Issue:16

    Topics: Anti-HIV Agents; Cross-Sectional Studies; Female; Genotype; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Pharmacogenetics; Polymorphism, Genetic; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Thailand

2017
Gp41 and Gag amino acids linked to HIV-1 protease inhibitor-based second-line failure in HIV-1 subtype A from Western Kenya.
    Journal of the International AIDS Society, 2017, Volume: 20, Issue:3

    Topics: Amino Acid Motifs; Drug Resistance, Viral; Female; gag Gene Products, Human Immunodeficiency Virus; HIV Envelope Protein gp41; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Kenya; Lopinavir; Male; Mutation; Treatment Failure

2017
Pharmacokinetics and Drug-Drug Interactions of Lopinavir-Ritonavir Administered with First- and Second-Line Antituberculosis Drugs in HIV-Infected Children Treated for Multidrug-Resistant Tuberculosis.
    Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:2

    Topics: Anti-HIV Agents; Antitubercular Agents; Child; Drug Administration Schedule; Drug Combinations; Drug Interactions; Ethambutol; Female; HIV; HIV Infections; Humans; Isoniazid; Lopinavir; Male; Models, Statistical; Mycobacterium tuberculosis; Pyrazinamide; Rifampin; Ritonavir; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary

2018
Protease inhibitors and preterm delivery: another piece in the puzzle.
    AIDS (London, England), 2018, Jan-14, Volume: 32, Issue:2

    Topics: Adult; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Female; HIV Infections; HIV Protease Inhibitors; Humans; Infant, Newborn; Ireland; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Premature Birth; Risk Assessment; Ritonavir; United Kingdom

2018
Characteristics of Treatment-experienced HIV-infected African Children and Adolescents Initiating Darunavir and/or Etravirine-based Antiretroviral Treatment.
    The Pediatric infectious disease journal, 2018, Volume: 37, Issue:7

    Topics: Adolescent; Anti-Retroviral Agents; Child; Child, Preschool; Cross-Sectional Studies; Darunavir; Eswatini; Female; HIV Infections; HIV-1; Humans; Kenya; Lesotho; Lopinavir; Male; Nitriles; Pyridazines; Pyrimidines; Raltegravir Potassium; Ritonavir; RNA, Viral; Viral Load; Young Adult; Zambia

2018
Results from the post-exposure prophylaxis pilot program (P-QUAD) demonstration project in Los Angeles County.
    International journal of STD & AIDS, 2018, Volume: 29, Issue:6

    Topics: Adolescent; Adult; Anti-HIV Agents; Female; HIV Infections; HIV-1; Homosexuality, Male; Humans; Lopinavir; Los Angeles; Male; Medication Adherence; Middle Aged; Pilot Projects; Post-Exposure Prophylaxis; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Ritonavir; Young Adult

2018
Population Pharmacokinetics of Lopinavir in Severely Malnourished HIV-infected Children and the Effect on Treatment Outcomes.
    The Pediatric infectious disease journal, 2018, Volume: 37, Issue:4

    Topics: Antiretroviral Therapy, Highly Active; Body Mass Index; Child; Child, Preschool; Female; HIV Infections; HIV Protease Inhibitors; Humans; Infant; Lopinavir; Male; Malnutrition; Plasma; Treatment Outcome

2018
Simultaneous quantification of four antiretroviral drugs in breast milk samples from HIV-positive women by an ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method.
    PloS one, 2018, Volume: 13, Issue:1

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Breast Feeding; Calibration; Chromatography, High Pressure Liquid; Colostrum; Female; HIV Infections; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Milk, Human; Pregnancy; Pregnancy Complications, Infectious; Reference Standards; Reproducibility of Results; Ritonavir; Tandem Mass Spectrometry; Young Adult; Zidovudine

2018
Long-Acting Profile of 4 Drugs in 1 Anti-HIV Nanosuspension in Nonhuman Primates for 5 Weeks After a Single Subcutaneous Injection.
    Journal of pharmaceutical sciences, 2018, Volume: 107, Issue:7

    Topics: Animals; Anti-HIV Agents; Drug Carriers; Drug Delivery Systems; Drug Therapy, Combination; HIV Infections; Injections, Subcutaneous; Lamivudine; Leukocytes, Mononuclear; Lopinavir; Lymph Nodes; Macaca nemestrina; Male; Nanoparticles; Ritonavir; Tenofovir

2018
Tenofovir disoproxil fumarate co-administered with lopinavir/ritonavir is strongly associated with tubular damage and chronic kidney disease.
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2018, Volume: 24, Issue:7

    Topics: Adult; Anti-HIV Agents; Cohort Studies; Cross-Sectional Studies; Drug Therapy, Combination; Female; HIV Infections; Humans; Kidney Tubules; Lopinavir; Male; Middle Aged; Renal Insufficiency, Chronic; Risk Factors; Ritonavir; Tenofovir; Vietnam

2018
Reciprocal Effects of Antiretroviral Drugs Used To Treat HIV Infection on the Fibroblast Growth Factor 21/β-Klotho System.
    Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:6

    Topics: Adipose Tissue; Alkynes; Anti-Retroviral Agents; Benzoxazines; Cyclopropanes; Diabetes Mellitus, Type 2; Drug Combinations; Endoplasmic Reticulum Stress; Fibroblast Growth Factors; Hep G2 Cells; HIV Infections; HIV Integrase Inhibitors; Humans; Klotho Proteins; Liver; Lopinavir; Maraviroc; Membrane Proteins; Muscle, Skeletal; Obesity; Oxidative Stress; Protease Inhibitors; Quinolones; Reverse Transcriptase Inhibitors; Ritonavir; Thapsigargin; Tunicamycin

2018
Birth Outcomes for Pregnant Women with HIV Using Tenofovir-Emtricitabine.
    The New England journal of medicine, 2018, 04-26, Volume: 378, Issue:17

    Topics: Adult; Anti-HIV Agents; Cohort Studies; Disease Transmission, Infectious; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; Humans; Infant, Low Birth Weight; Infant, Newborn; Lamivudine; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Premature Birth; Risk; Ritonavir; Tenofovir; Zidovudine

2018
HIV-1 status is independently associated with decreased erectile function among middle-aged MSM in the era of combination antiretroviral therapy.
    AIDS (London, England), 2018, 06-01, Volume: 32, Issue:9

    Topics: Anti-Retroviral Agents; Cross-Sectional Studies; Erectile Dysfunction; HIV Infections; Homosexuality, Male; Humans; Lopinavir; Male; Middle Aged; Ritonavir; Surveys and Questionnaires

2018
Biomarkers of Aging in HIV-Infected Children on Suppressive Antiretroviral Therapy.
    Journal of acquired immune deficiency syndromes (1999), 2018, 08-15, Volume: 78, Issue:5

    Topics: Aging; Biomarkers; Case-Control Studies; Child; Child, Preschool; Cohort Studies; DNA Methylation; Enzyme-Linked Immunosorbent Assay; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Multiplex Polymerase Chain Reaction; Ritonavir; South Africa; Telomere

2018
Plasma metabolic changes in Chinese HIV-infected patients receiving lopinavir/ritonavir based treatment: Implications for HIV precision therapy.
    Cytokine, 2018, Volume: 110

    Topics: Adult; Aged; Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes; Disease Progression; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Plasma; Precision Medicine; Ritonavir; ROC Curve; Young Adult

2018
Evaluation of adhesion molecules and immune parameters in HIV-infected patients treated with an atazanavir/ritonavir- compared with a lopinavir/ritonavir-based regimen.
    The Journal of antimicrobial chemotherapy, 2018, 08-01, Volume: 73, Issue:8

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Atherosclerosis; Biomarkers; Carotid Intima-Media Thickness; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Adhesion Molecules; Endothelial Cells; Female; Follow-Up Studies; HIV Infections; Humans; Lopinavir; Lymphocyte Activation; Male; Prospective Studies; Pulse Wave Analysis; Random Allocation; Ritonavir

2018
Lopinavir/ritonavir treatment increases the placental transfer of bupivacaine enantiomers in human immunodeficiency virus-infected pregnant women.
    British journal of clinical pharmacology, 2018, Volume: 84, Issue:10

    Topics: Adult; Amniotic Fluid; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Bupivacaine; Case-Control Studies; Cesarean Section; Drug Combinations; Female; Fetal Blood; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Maternal-Fetal Exchange; Permeability; Placenta; Pregnancy; Pregnancy Complications, Infectious; Ritonavir

2018
Efavirenz and Lopinavir Levels in HIV-Infected Women and Their Nursing Infants, in Mali.
    The Journal of pharmacology and experimental therapeutics, 2018, Volume: 366, Issue:3

    Topics: Adolescent; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Breast Feeding; Cyclopropanes; Female; HIV Infections; Humans; Infant; Lopinavir; Male; Mali; Mothers; Safety; Tissue Distribution; Young Adult

2018
Using dried blood spots to facilitate therapeutic drug monitoring of antiretroviral drugs in resource-poor regions.
    The Journal of antimicrobial chemotherapy, 2018, 10-01, Volume: 73, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Alkynes; Anti-Retroviral Agents; Benzoxazines; Biological Transport; Cohort Studies; Cyclopropanes; Dried Blood Spot Testing; Drug Monitoring; Female; Health Resources; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Nevirapine; Rural Population; Switzerland; Tanzania

2018
HIV viral suppression and longevity among a cohort of children initiating antiretroviral therapy in Eastern Cape, South Africa.
    Journal of the International AIDS Society, 2018, Volume: 21, Issue:8

    Topics: Adult; Alkynes; Ambulatory Care Facilities; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; Child; Child, Preschool; Cohort Studies; Cyclopropanes; Dideoxynucleosides; Female; Health Resources; HIV Infections; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Male; Medication Adherence; Ritonavir; South Africa; Viral Load

2018
Metabolic effects of initiating lopinavir/ritonavir-based regimens among young children.
    AIDS (London, England), 2018, 10-23, Volume: 32, Issue:16

    Topics: Anti-HIV Agents; Blood Chemical Analysis; Child, Preschool; Female; Follow-Up Studies; HIV Infections; Humans; Infant; Lopinavir; Male; Metabolome; Metabolomics; Prospective Studies; Randomized Controlled Trials as Topic; Ritonavir

2018
HIV-1 second-line failure and drug resistance at high-level and low-level viremia in Western Kenya.
    AIDS (London, England), 2018, 11-13, Volume: 32, Issue:17

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Cross-Sectional Studies; Drug Resistance, Viral; Female; Genotype; HIV Infections; HIV-1; Humans; Kenya; Lopinavir; Male; Middle Aged; pol Gene Products, Human Immunodeficiency Virus; Ritonavir; Sequence Analysis, DNA; Treatment Failure; Viral Load; Viremia

2018
Absence of effect of the antiretrovirals Duovir and Viraday on mitochondrial bioenergetics.
    Journal of cellular biochemistry, 2018, Volume: 119, Issue:12

    Topics: Adenosine Triphosphate; Animals; Anti-Retroviral Agents; Drug Combinations; Energy Metabolism; Hepatocytes; HIV Infections; Ion Channels; Lopinavir; Mice; Mitochondria; Mitochondria, Liver; Mitochondrial Proteins; Oxidative Stress; Reactive Oxygen Species; Ritonavir

2018
A three-in-one, long-acting, nanosuspension reformulation of off-patent antiretrovirals for low-income and middle-income countries.
    AIDS (London, England), 2018, 11-13, Volume: 32, Issue:17

    Topics: Alkynes; Animals; Benzoxazines; Cyclopropanes; HIV Infections; Lopinavir; Primates; Tenofovir

2018
Multidrug nanosuspensions: future perspectives on drug delivery system for HIV combination antiretroviral therapy.
    AIDS (London, England), 2018, 11-13, Volume: 32, Issue:17

    Topics: Alkynes; Animals; Benzoxazines; Cyclopropanes; Drug Delivery Systems; HIV; HIV Infections; Lopinavir; Primates; Tenofovir

2018
A Clinical Prediction Rule for Protease Inhibitor Resistance in Patients Failing Second-Line Antiretroviral Therapy.
    Journal of acquired immune deficiency syndromes (1999), 2019, 03-01, Volume: 80, Issue:3

    Topics: Adult; Atazanavir Sulfate; Drug Resistance, Viral; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Logistic Models; Lopinavir; Male; Middle Aged; Multivariate Analysis; Mutation

2019
Assessing the adoption of lopinavir/ritonavir oral pellets for HIV-positive children in Zimbabwe.
    Journal of the International AIDS Society, 2018, Volume: 21, Issue:12

    Topics: Anti-HIV Agents; Caregivers; Child, Preschool; Drug Combinations; Drug Implants; Female; HIV Infections; Humans; Infant; Lopinavir; Male; Ritonavir; Viral Load; Zimbabwe

2018
Antiretroviral Drug Concentrations in Breastmilk, Maternal HIV Viral Load, and HIV Transmission to the Infant: Results From the BAN Study.
    Journal of acquired immune deficiency syndromes (1999), 2019, 04-01, Volume: 80, Issue:4

    Topics: Adolescent; Adult; Anti-HIV Agents; Breast Feeding; Female; HIV Infections; HIV-1; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Middle Aged; Milk, Human; Pregnancy; Ritonavir; RNA, Viral; Viral Load; Young Adult; Zidovudine

2019
Dolutegravir for second-line antiretroviral therapy.
    The Lancet. Infectious diseases, 2019, Volume: 19, Issue:3

    Topics: Adult; Heterocyclic Compounds, 3-Ring; HIV Infections; HIV-1; Humans; Lopinavir; Oxazines; Piperazines; Pyridones; Ritonavir; RNA-Directed DNA Polymerase

2019
Gag-protease coevolution shapes the outcome of lopinavir-inclusive treatment regimens in chronically infected HIV-1 subtype C patients.
    Bioinformatics (Oxford, England), 2019, 09-15, Volume: 35, Issue:18

    Topics: Bayes Theorem; Drug Resistance, Viral; gag Gene Products, Human Immunodeficiency Virus; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Mutation; Phylogeny

2019
Optimising HIV antiretrovirals for mothers and infants.
    The lancet. HIV, 2019, Volume: 6, Issue:5

    Topics: Female; HIV Infections; HIV-1; Humans; Infant; Lamivudine; Lopinavir; Mothers; Ritonavir

2019
An observational study in an urban Ugandan clinic comparing virological outcomes of patients switched from first-line antiretroviral regimens to second-line regimens containing ritonavir-boosted atazanavir or ritonavir-boosted lopinavir.
    BMC infectious diseases, 2019, Mar-25, Volume: 19, Issue:1

    Topics: Adult; Ambulatory Care Facilities; Anti-HIV Agents; Atazanavir Sulfate; Cross-Sectional Studies; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Ritonavir; Uganda; Viral Load

2019
Symptomatic HIV CNS viral escape among patients on effective cART.
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2019, Volume: 84

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Central Nervous System Viral Diseases; Encephalitis; Female; HIV Infections; Humans; India; Lamivudine; Lopinavir; Male; Plasma; Retrospective Studies; Viral Load

2019
Pursuing use of optimal formulations for paediatric HIV epidemic control - a look at the use of LPV/r oral pellets and oral granules.
    Journal of the International AIDS Society, 2019, Volume: 22, Issue:4

    Topics: Administration, Oral; Adolescent; Anti-HIV Agents; Child; Child, Preschool; Drug Combinations; Drug Compounding; Epidemics; Female; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Lopinavir; Male; Pediatrics; Ritonavir

2019
A Profile of Adverse Drug Reactions of Atazanavir- and Lopinavir-Based Antiretroviral Regimens in Namibia.
    Drug safety, 2019, Volume: 42, Issue:7

    Topics: Adult; Anti-HIV Agents; Atazanavir Sulfate; Databases, Factual; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Namibia; Pharmacovigilance; Young Adult

2019
Pharmacokinetics of adjusted-dose 8-hourly lopinavir/ritonavir in HIV-infected children co-treated with rifampicin.
    The Journal of antimicrobial chemotherapy, 2019, 08-01, Volume: 74, Issue:8

    Topics: Alanine Transaminase; Anti-HIV Agents; Antibiotics, Antitubercular; Child; Child, Preschool; Drug Combinations; Female; HIV Infections; Humans; Infant; Infant, Newborn; Lopinavir; Male; Plasma; Prospective Studies; Rifampin; Ritonavir; Treatment Outcome; Tuberculosis

2019
Neurodevelopmental effects of ante-partum and post-partum antiretroviral exposure in HIV-exposed and uninfected children versus HIV-unexposed and uninfected children in Uganda and Malawi: a prospective cohort study.
    The lancet. HIV, 2019, Volume: 6, Issue:8

    Topics: Anti-Retroviral Agents; Breast Feeding; Child, Preschool; Cohort Studies; Drug Combinations; Female; HIV Infections; Humans; Infant; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Malawi; Male; Post-Exposure Prophylaxis; Postpartum Period; Pre-Exposure Prophylaxis; Pregnancy; Pregnancy Complications, Infectious; Prospective Studies; Ritonavir; Uganda; Zidovudine

2019
Safety and efficacy of rifabutin among HIV/TB-coinfected children on lopinavir/ritonavir-based ART.
    The Journal of antimicrobial chemotherapy, 2019, 09-01, Volume: 74, Issue:9

    Topics: Antibiotics, Antitubercular; Antiretroviral Therapy, Highly Active; Biomarkers; Coinfection; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Female; HIV Infections; Humans; Lopinavir; Male; Retrospective Studies; Rifabutin; Ritonavir; Treatment Outcome; Tuberculosis

2019
Does less equal more yet?
    The lancet. HIV, 2019, Volume: 6, Issue:7

    Topics: Darunavir; HIV Infections; Humans; Lopinavir; Ritonavir; RNA

2019
Complications of long-term antiretroviral therapy in HIV-infected children.
    Archives of disease in childhood, 2013, Volume: 98, Issue:4

    Topics: Anti-HIV Agents; Body Composition; Female; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Lipids; Lopinavir; Male; Nevirapine

2013
Orbital floor triamcinolone causing Cushing's syndrome in a patient treated with Kaletra for HIV 1.
    BMJ case reports, 2013, Feb-25, Volume: 2013

    Topics: Adult; Cushing Syndrome; Diagnosis, Differential; Drug Combinations; Drug Interactions; Female; Follow-Up Studies; Glucocorticoids; HIV Infections; HIV-1; Humans; Injections; Lopinavir; Orbit; Ritonavir; Tomography, Optical Coherence; Triamcinolone

2013
The potential cost and benefits of raltegravir in simplified second-line therapy among HIV infected patients in Nigeria and South Africa.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Antiretroviral Therapy, Highly Active; Cost-Benefit Analysis; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Models, Biological; Models, Economic; Nigeria; Pyrrolidinones; Quality-Adjusted Life Years; Raltegravir Potassium; Ritonavir; South Africa

2013
Cost-utility analysis of lopinavir/ritonavir versus atazanavir + ritonavir administered as first-line therapy for the treatment of HIV infection in Italy: from randomised trial to real world.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Anti-HIV Agents; Atazanavir Sulfate; Cost-Benefit Analysis; HIV Infections; Humans; Italy; Lopinavir; Oligopeptides; Pyridines; Quality of Life; Randomized Controlled Trials as Topic; Ritonavir

2013
Pharmacokinetics of maraviroc administered at 150 mg once daily in association with lopinavir/ritonavir in HIV-positive treatment-naive patients.
    The Journal of antimicrobial chemotherapy, 2013, Volume: 68, Issue:7

    Topics: Adult; Anti-HIV Agents; Cyclohexanes; Drug Therapy, Combination; HIV Infections; Humans; Lopinavir; Male; Maraviroc; Plasma; Ritonavir; Time Factors; Triazoles

2013
Influence of MDR1 C1236T polymorphism on lopinavir plasma concentration and virological response in HIV-1-infected children.
    Gene, 2013, Jun-10, Volume: 522, Issue:1

    Topics: Adolescent; Adult; Antiretroviral Therapy, Highly Active; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; CD4-Positive T-Lymphocytes; Child; Child, Preschool; Female; Gene Frequency; Genotype; Heterozygote; HIV Infections; HIV Protease Inhibitors; HIV-1; Homozygote; Humans; Infant; Lopinavir; Male; Polymorphism, Single Nucleotide; Pregnane X Receptor; Receptors, Steroid; Young Adult

2013
Lopinavir/ritonavir versus darunavir plus ritonavir for HIV infection: a cost-effectiveness analysis for the United States.
    PharmacoEconomics, 2013, Volume: 31, Issue:5

    Topics: Adult; Anti-HIV Agents; Cost-Benefit Analysis; Darunavir; Drug Combinations; Drug Therapy, Combination; Female; Health Care Costs; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Models, Economic; Prognosis; Quality-Adjusted Life Years; Ritonavir; Sulfonamides; Time Factors; Treatment Outcome; United States

2013
[Usefulness of plasma lopinavir levels during pregnancy].
    Enfermedades infecciosas y microbiologia clinica, 2013, Volume: 31, Issue:10

    Topics: Adult; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pregnancy; Pregnancy Complications, Infectious

2013
Talk of HIV cure goes viral.
    The Lancet. Infectious diseases, 2013, Volume: 13, Issue:4

    Topics: Adult; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Child, Preschool; DNA, Viral; Drug Administration Schedule; Drug Therapy, Combination; HIV Infections; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Male; Nevirapine; Primary Prevention; Ritonavir; Secondary Prevention; Time Factors; Zidovudine

2013
Contribution of follicular dendritic cells to persistent HIV viremia.
    Journal of virology, 2013, Volume: 87, Issue:14

    Topics: Dendritic Cells, Follicular; Drug Combinations; HIV Infections; HIV-1; Humans; Kinetics; Lamivudine; Lopinavir; Models, Biological; Ritonavir; Stavudine; Viral Load; Viremia; Virus Release

2013
Left ventricular hypertrophy detected by echocardiography in HIV-infected patients.
    European journal of internal medicine, 2013, Volume: 24, Issue:6

    Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Carbamates; Comorbidity; Cross-Sectional Studies; Cyclopropanes; Diabetes Mellitus; Drug Combinations; Dyslipidemias; Echocardiography; Female; Furans; HIV Infections; Humans; Hypertension; Hypertrophy, Left Ventricular; Lamivudine; Lopinavir; Male; Middle Aged; Nevirapine; Organophosphates; Organophosphonates; Risk Factors; Ritonavir; Smoking; Spain; Sulfonamides; Tenofovir; Zidovudine

2013
Structural modifications induced by specific HIV-1 protease-compensatory mutations have an impact on the virological response to a first-line lopinavir/ritonavir-containing regimen.
    The Journal of antimicrobial chemotherapy, 2013, Volume: 68, Issue:10

    Topics: Adult; Anti-HIV Agents; Female; HIV Infections; HIV Protease; HIV-1; Humans; Lopinavir; Male; Middle Aged; Mutation, Missense; Ritonavir; Suppression, Genetic; Treatment Outcome; Viral Load

2013
Lopinavir plasma concentrations and virological outcome with lopinavir-ritonavir monotherapy in HIV-1-infected patients.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:8

    Topics: Adult; Aged; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Patient Compliance; Proportional Hazards Models; Prospective Studies; Ritonavir; RNA, Viral; Treatment Failure; Viral Load

2013
Durability of first ART regimen and risk factors for modification, interruption or death in HIV-positive patients starting ART in Europe and North America 2002-2009.
    AIDS (London, England), 2013, Mar-13, Volume: 27, Issue:5

    Topics: Adenine; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cohort Studies; Cyclopropanes; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Europe; HIV Infections; HIV Protease Inhibitors; HIV Seropositivity; HIV-1; Humans; Lamivudine; Lopinavir; Nevirapine; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Factors; Tenofovir; Time Factors; United States

2013
After first-line ART: towards an evidence-based SECOND-LINE.
    Lancet (London, England), 2013, Jun-15, Volume: 381, Issue:9883

    Topics: Anti-HIV Agents; Female; HIV Infections; Humans; Lopinavir; Male; Pyrrolidinones; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Ritonavir

2013
Mortality and long-term virologic outcomes in children and infants treated with lopinavir/ritonavir.
    The Pediatric infectious disease journal, 2013, Volume: 32, Issue:12

    Topics: Child; Child, Preschool; Female; HIV Infections; HIV Protease Inhibitors; Humans; Infant; Infant, Newborn; Lopinavir; Male; Retrospective Studies; Risk Factors; Ritonavir; Survival Analysis; Viral Load

2013
The effect of antiretrovirals on Plasmodium falciparum liver stages.
    AIDS (London, England), 2013, Jun-19, Volume: 27, Issue:10

    Topics: HIV Infections; HIV Protease Inhibitors; Humans; In Vitro Techniques; Liver; Lopinavir; Malaria, Falciparum; Nevirapine; Plasmodium falciparum; Reverse Transcriptase Inhibitors; Saquinavir

2013
Boosted or unboosted atazanavir as a simplification of lopinavir/ritonavir-containing regimens.
    The new microbiologica, 2013, Volume: 36, Issue:3

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Multivariate Analysis; Oligopeptides; Pyridines; Retrospective Studies; Ritonavir; Treatment Outcome; Viral Load

2013
Virological efficacy in cerebrospinal fluid and neurocognitive status in patients with long-term monotherapy based on lopinavir/ritonavir: an exploratory study.
    PloS one, 2013, Volume: 8, Issue:7

    Topics: Adult; Anti-HIV Agents; Cognition Disorders; Cross-Sectional Studies; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Ritonavir; RNA, Viral; Viral Load

2013
[Ophthalmological alterations at the initial diagnosis of HIV infection].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2014, Volume: 111, Issue:7

    Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; Cyclohexanes; Deoxycytidine; Drug Therapy, Combination; Early Diagnosis; Emtricitabine; Eye Infections, Viral; HIV Infections; Humans; Lopinavir; Male; Maraviroc; Organophosphonates; Retinal Diseases; Syndrome; Tenofovir; Treatment Outcome; Triazoles; Zidovudine

2014
Pharmacogenetic analysis of SNPs in genes involved in the pharmacokinetics and response to lopinavir/ritonavir therapy.
    Current drug metabolism, 2013, Volume: 14, Issue:7

    Topics: Adolescent; Adult; Aged; CD4 Lymphocyte Count; Drug Therapy, Combination; Female; Genotype; HIV Infections; HIV Protease Inhibitors; Humans; Lipids; Lopinavir; Male; Middle Aged; Polymorphism, Single Nucleotide; Receptors, Dopamine D3; Ritonavir; Treatment Outcome; Young Adult

2013
Pharmacokinetics of lopinavir determined with an ELISA test in youths with perinatally acquired HIV.
    Indian journal of pediatrics, 2014, Volume: 81, Issue:9

    Topics: Adolescent; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Female; HIV Infections; HIV Protease Inhibitors; Humans; Infant; Infectious Disease Transmission, Vertical; Lopinavir; Male; Young Adult

2014
Durability of lopinavir/ritonavir monotherapy in individuals with viral load ≤50 copies/ml in an observational setting.
    Antiviral therapy, 2014, Volume: 19, Issue:3

    Topics: Adult; Anti-HIV Agents; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Prospective Studies; Ritonavir; RNA, Viral; Substance-Related Disorders; Time Factors; Viral Load

2014
Cardio-metabolic effectsof HIV protease inhibitors (lopinavir/ritonavir).
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Analysis of Variance; Animals; Antiretroviral Therapy, Highly Active; Blotting, Western; Calcineurin; Calcium-Binding Proteins; Cholesterol, LDL; Connexin 43; DNA Primers; Drug Combinations; Gene Expression Regulation, Enzymologic; HIV Infections; HIV Protease Inhibitors; Liver; Lopinavir; Male; Myocardium; NFATC Transcription Factors; Oxidative Stress; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Ritonavir; Triglycerides

2013
[Sick sinus syndrome possibly due to lopinavir-ritonavir: report of two cases].
    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 2013, Volume: 87, Issue:5

    Topics: Aged; Anti-Retroviral Agents; Drug Therapy, Combination; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Ritonavir; Sick Sinus Syndrome

2013
Are lopinavir and efavirenz serum concentrations in HIV-infected children in the therapeutic range in clinical practice?
    Paediatrics and international child health, 2014, Volume: 34, Issue:2

    Topics: Adolescent; Alkynes; Anti-HIV Agents; Benzoxazines; Child; Child, Preschool; Chromatography, Liquid; Cyclopropanes; Drug Monitoring; Female; HIV Infections; Hospitals; Humans; Infant; Lopinavir; Male; Prospective Studies; Serum; South Africa

2014
Insulin resistance and lipid profiles in HIV-infected Thai children receiving lopinavir/ritonavir-based highly active antiretroviral therapy.
    Journal of pediatric endocrinology & metabolism : JPEM, 2014, Volume: 27, Issue:5-6

    Topics: Adipokines; Adolescent; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Blood Glucose; Child; Child, Preschool; Dyslipidemias; Female; HIV Infections; Humans; Insulin Resistance; Lipids; Lopinavir; Male; Pregnancy; Ritonavir; Thailand

2014
Simplifying antiretroviral therapy to lopinavir/ritonavir monotherapy did not improve quality of life and therapy adherence in pretreated HIV-infected children.
    AIDS research and human retroviruses, 2014, Volume: 30, Issue:3

    Topics: Adolescent; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Child; Female; HIV Infections; Humans; Lopinavir; Male; Medication Adherence; Quality of Life; Ritonavir; Thailand

2014
Effects of combined zidovudine/lopinavir/ritonavir therapy during rat pregnancy: morphological aspects.
    Clinical and experimental obstetrics & gynecology, 2013, Volume: 40, Issue:3

    Topics: Animals; Blood Urea Nitrogen; Creatinine; Dose-Response Relationship, Drug; Female; Fetus; HIV Infections; HIV Protease Inhibitors; Kidney; Liver; Lopinavir; Pancreas; Pregnancy; Pregnancy Complications, Infectious; Rats; Rats, Wistar; Ritonavir; Zidovudine

2013
[HIV prophylaxis kits. A concept for emergency treatment in the context of postexposure prophylaxis].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2014, Volume: 85, Issue:1

    Topics: Administration, Oral; Anti-HIV Agents; Deoxycytidine; Drug Administration Schedule; Drug Combinations; Early Medical Intervention; Emergency Treatment; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Germany; HIV Infections; Humans; Infectious Disease Transmission, Patient-to-Professional; Lopinavir; Needlestick Injuries; Organophosphorus Compounds; Post-Exposure Prophylaxis; Pyrrolidinones; Raltegravir Potassium; Ritonavir

2014
Does a significant reduction in malaria risk make lopinavir/ritonavir-based ART cost-effective for children with HIV in co-endemic, low-resource settings?
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 2014, Volume: 108, Issue:1

    Topics: Anti-Retroviral Agents; Child, Preschool; Cohort Studies; Coinfection; Cost-Benefit Analysis; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Incidence; Infant; Lopinavir; Malaria; Male; Quality-Adjusted Life Years; Ritonavir; Uganda

2014
Integrated population pharmacokinetic/viral dynamic modelling of lopinavir/ritonavir in HIV-1 treatment-naïve patients.
    Clinical pharmacokinetics, 2014, Volume: 53, Issue:4

    Topics: Adult; Algorithms; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Models, Statistical; Orosomucoid; Population; Ritonavir; Viral Load

2014
Cost-minimization comparison of darunavir plus ritonavir and lopinavir/ritonavir in HIV-1 infected treatment-naïve women of childbearing age.
    Journal of medical economics, 2014, Volume: 17, Issue:4

    Topics: Adult; CD4 Lymphocyte Count; Cost-Benefit Analysis; Darunavir; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Markov Chains; Quality-Adjusted Life Years; Ritonavir; Sulfonamides; United States; Viral Load

2014
Pharmacokinetics of pediatric lopinavir/ritonavir tablets in children when administered twice daily according to FDA weight bands.
    The Pediatric infectious disease journal, 2014, Volume: 33, Issue:3

    Topics: Adolescent; Analysis of Variance; Body Weight; Child; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Ritonavir; Tablets

2014
Atazanavir and lopinavir profile in pregnant women with HIV: tolerability, activity and pregnancy outcomes in an observational national study.
    The Journal of antimicrobial chemotherapy, 2014, Volume: 69, Issue:5

    Topics: Adult; Anti-HIV Agents; Atazanavir Sulfate; CD4 Lymphocyte Count; Female; HIV Infections; Humans; Lipids; Liver Function Tests; Lopinavir; Oligopeptides; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Pyridines; RNA, Viral; Viral Load

2014
Generic antiretroviral drugs in developing countries: friends or foes?
    AIDS (London, England), 2014, Feb-20, Volume: 28, Issue:4

    Topics: Anti-Retroviral Agents; Congo; Developing Countries; Drugs, Generic; HIV Infections; Humans; Lopinavir; Ritonavir; Treatment Outcome

2014
Implementing the Jadelle implant for women living with HIV in a resource-limited setting: concerns for drug interactions leading to unintended pregnancies.
    AIDS (London, England), 2014, Mar-13, Volume: 28, Issue:5

    Topics: Adolescent; Adult; Alkynes; Anti-Retroviral Agents; Benzoxazines; Contraceptive Agents, Female; Cyclopropanes; Drug Interactions; Eswatini; Female; HIV Infections; Humans; Lopinavir; Middle Aged; Nevirapine; Pregnancy; Pregnancy, Unplanned; Ritonavir; Young Adult

2014
Effectiveness of ritonavir-boosted protease inhibitor monotherapy in the clinical setting: same results as in clinical trials? The PIMOCS Study Group.
    The Journal of antimicrobial chemotherapy, 2014, Volume: 69, Issue:5

    Topics: Adult; CD4 Lymphocyte Count; Darunavir; Drug-Related Side Effects and Adverse Reactions; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Maintenance Chemotherapy; Male; Middle Aged; Retrospective Studies; Ritonavir; Sulfonamides; Treatment Outcome; Viral Load

2014
Comparable long-term efficacy of Lopinavir/Ritonavir and similar drug-resistance profiles in different HIV-1 subtypes.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Analysis of Variance; Base Sequence; Drug Combinations; Drug Resistance, Viral; HIV Infections; HIV-1; Humans; Israel; Lopinavir; Molecular Sequence Data; Retrospective Studies; Ritonavir; Sequence Analysis, DNA; Species Specificity

2014
Concentration-response model of lopinavir/ritonavir in HIV-1-infected pediatric patients.
    The Pediatric infectious disease journal, 2014, Volume: 33, Issue:8

    Topics: Adolescent; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Child; Child, Preschool; Computer Simulation; Dose-Response Relationship, Drug; Female; HIV Infections; HIV-1; Humans; Infant; Infant, Newborn; Lopinavir; Male; Models, Biological; Practice Guidelines as Topic; Retrospective Studies; Ritonavir; Viral Load

2014
Achilles tendinopathy following Kaletra (lopinavir/ritonavir) use.
    International journal of STD & AIDS, 2014, Volume: 25, Issue:11

    Topics: Achilles Tendon; Adult; CD4 Lymphocyte Count; Drug Combinations; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Magnetic Resonance Imaging; Male; Ritonavir; Tendinopathy; Treatment Outcome

2014
Accelerated suppression of primary Epstein-Barr virus infection in HIV-infected infants initiating lopinavir/ritonavir-based versus nevirapine-based combination antiretroviral therapy.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014, Volume: 58, Issue:9

    Topics: Anti-HIV Agents; Drug Therapy, Combination; Epstein-Barr Virus Infections; HIV Infections; Humans; Infant; Kenya; Lopinavir; Nevirapine; Risk Factors; Ritonavir

2014
Comparative impact of antiretroviral drugs on markers of inflammation and immune activation during the first two years of effective therapy for HIV-1 infection: an observational study.
    BMC infectious diseases, 2014, Mar-04, Volume: 14

    Topics: Adult; Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; C-Reactive Protein; CD4 Lymphocyte Count; Chemokine CXCL10; Cyclopropanes; Female; HIV Infections; HIV-1; Humans; Immune System; Inflammation; Interferon-gamma; Interleukin-6; Lipopolysaccharide Receptors; Lopinavir; Male; Middle Aged; Oligopeptides; Pyridines; Ritonavir; Treatment Outcome

2014
The effect of lopinavir/ritonavir on the antimalarial activity of artemether or artemether/lumefantrine in a mouse model of Plasmodium berghei.
    Journal of chemotherapy (Florence, Italy), 2015, Volume: 27, Issue:1

    Topics: Animals; Anti-Retroviral Agents; Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Coinfection; Disease Models, Animal; Drug Combinations; Drug Interactions; Ethanolamines; Fluorenes; HIV Infections; Lopinavir; Malaria; Mice; Plasmodium berghei; Ritonavir

2015
Do lopinavir and ritonavir require a dose adjustment during pregnancy?
    Journal of acquired immune deficiency syndromes (1999), 2014, Jul-01, Volume: 66, Issue:3

    Topics: Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Ritonavir

2014
Phylogenetic evidence of HIV-1 sequence evolution in subjects with persistent low-level viraemia.
    Antiviral therapy, 2015, Volume: 20, Issue:1

    Topics: Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Drug Resistance, Viral; Evolution, Molecular; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Mutation; Phylogeny; pol Gene Products, Human Immunodeficiency Virus; Retrospective Studies; Ritonavir; RNA, Viral; Viral Load; Viremia

2015
Initial therapy for HIV: can less be more?
    The Lancet. Infectious diseases, 2014, Volume: 14, Issue:7

    Topics: Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Male; Reverse Transcriptase Inhibitors; Ritonavir

2014
Drug susceptibility and resistance mutations after first-line failure in resource limited settings.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014, Sep-01, Volume: 59, Issue:5

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Resistance, Viral; Female; Health Resources; HIV Infections; HIV-1; Humans; India; Lopinavir; Malawi; Male; Middle Aged; Mutation Rate; Nitriles; Pilot Projects; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Ritonavir; South Africa; Tanzania; Thailand; Treatment Failure; Young Adult

2014
Intracellular antiviral activity of low-dose ritonavir in boosted protease inhibitor regimens.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:7

    Topics: Adult; Algorithms; Antiviral Agents; Cells; Darunavir; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Monocytes; Peptide Hydrolases; Ritonavir

2014
Extensive pulmonary involvement with raltegravir-induced DRESS syndrome in a postpartum woman with HIV.
    BMJ case reports, 2014, May-05, Volume: 2014

    Topics: Adolescent; Anti-HIV Agents; Drug Combinations; Drug Hypersensitivity Syndrome; Female; HIV Infections; HIV Integrase Inhibitors; Humans; Lamivudine; Lopinavir; Pleural Effusion; Postpartum Period; Pyrrolidinones; Radiography; Raltegravir Potassium; Respiratory Distress Syndrome; Ritonavir; Zidovudine

2014
Seminal pharmacokinetics and antiviral efficacy of once-daily maraviroc plus lopinavir/ritonavir in HIV-infected patients.
    The Journal of antimicrobial chemotherapy, 2014, Volume: 69, Issue:9

    Topics: Adult; Anti-HIV Agents; Cyclohexanes; HIV Infections; Humans; Lopinavir; Male; Maraviroc; Middle Aged; Plasma; Ritonavir; Semen; Triazoles

2014
Double-dose lopinavir-ritonavir in combination with rifampicin-based anti-tuberculosis treatment in South Africa.
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2014, Volume: 18, Issue:6

    Topics: Adult; Antibiotics, Antitubercular; Coinfection; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Retrospective Studies; Rifampin; Ritonavir; South Africa; Treatment Outcome; Tuberculosis; Viral Load; Young Adult

2014
Cost effectiveness of darunavir/ritonavir combination antiretroviral therapy for treatment-naive adults with HIV-1 infection in Canada.
    PharmacoEconomics, 2014, Volume: 32, Issue:9

    Topics: Adult; Antiretroviral Therapy, Highly Active; Canada; CD4 Lymphocyte Count; Clinical Trials, Phase III as Topic; Cost-Benefit Analysis; Darunavir; Drug Combinations; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Markov Chains; Ritonavir

2014
Modified pullulan nanoparticles for oral delivery of lopinavir: formulation and pharmacokinetic evaluation.
    Carbohydrate polymers, 2014, Sep-22, Volume: 110

    Topics: Acetylation; Administration, Oral; Animals; Drug Carriers; Glucans; HIV Infections; HIV Protease Inhibitors; Lopinavir; Male; Nanoparticles; Rats; Rats, Wistar; Tissue Distribution

2014
CYP3A4*22 (c.522-191 C>T; rs35599367) is associated with lopinavir pharmacokinetics in HIV-positive adults.
    Pharmacogenetics and genomics, 2014, Volume: 24, Issue:9

    Topics: Adult; Aged; Cytochrome P-450 CYP3A; Female; Genetic Variation; HIV Infections; HIV Protease Inhibitors; Humans; Liver-Specific Organic Anion Transporter 1; Lopinavir; Male; Middle Aged; Organic Anion Transporters; Polymorphism, Single Nucleotide

2014
Analysis of single-nucleotide polymorphisms (SNPs) in human CYP3A4 and CYP3A5 genes: potential implications for the metabolism of HIV drugs.
    BMC medical genetics, 2014, Jul-02, Volume: 15

    Topics: Adult; Alleles; Anti-HIV Agents; CD4 Lymphocyte Count; Cytochrome P-450 CYP3A; Female; Gene Frequency; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Pharmacogenetics; Polymorphism, Single Nucleotide; Treatment Outcome; Viral Load

2014
Side effects and tolerability of post-exposure prophylaxis with zidovudine, lamivudine, and lopinavir/ritonavir: a comparative study with HIV/AIDS patients.
    Chinese medical journal, 2014, Volume: 127, Issue:14

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; HIV Infections; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Post-Exposure Prophylaxis; Retrospective Studies; Ritonavir; Zidovudine

2014
Determination of total and unbound concentrations of lopinavir in plasma using liquid chromatography-tandem mass spectrometry and ultrafiltration methods.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014, Aug-15, Volume: 965

    Topics: Chromatography, High Pressure Liquid; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Female; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Randomized Controlled Trials as Topic; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Ultrafiltration

2014
Phenotypic characterization of virological failure following lopinavir/ritonavir monotherapy using full-length Gag-protease genes.
    The Journal of antimicrobial chemotherapy, 2014, Volume: 69, Issue:12

    Topics: Anti-HIV Agents; Drug Resistance, Viral; gag Gene Products, Human Immunodeficiency Virus; Genotype; HIV Infections; HIV Protease; Humans; Lopinavir; Microbial Sensitivity Tests; Phenotype; Ritonavir; Treatment Failure

2014
Short communication: focal encephalitis related to viral escape and resistance emergence in cerebrospinal fluid in a patient on lopinavir/ritonavir monotherapy with plasma HIV-1 RNA suppression.
    AIDS research and human retroviruses, 2014, Volume: 30, Issue:10

    Topics: Adult; Encephalitis, Viral; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Ritonavir

2014
A prospective cohort study of neurocognitive function in aviremic HIV-infected patients treated with 1 or 3 antiretrovirals.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014, Dec-01, Volume: 59, Issue:11

    Topics: Adult; Antiretroviral Therapy, Highly Active; Cognition Disorders; Darunavir; Female; HIV Infections; HIV Protease Inhibitors; Humans; Longitudinal Studies; Lopinavir; Male; Middle Aged; Prospective Studies; Sulfonamides

2014
HIV-1 subtype influences susceptibility and response to monotherapy with the protease inhibitor lopinavir/ritonavir.
    The Journal of antimicrobial chemotherapy, 2015, Volume: 70, Issue:1

    Topics: Female; gag Gene Products, Human Immunodeficiency Virus; Genotype; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Microbial Sensitivity Tests; Ritonavir; Sequence Analysis, DNA; Treatment Failure

2015
Induction with lopinavir-based treatment followed by switch to nevirapine-based regimen versus non-nucleoside reverse transcriptase inhibitors-based treatment for first line antiretroviral therapy in HIV infected children three years and older.
    PloS one, 2014, Volume: 9, Issue:9

    Topics: Child; Child, Preschool; Drug Resistance, Viral; Drug Substitution; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Induction Chemotherapy; Lopinavir; Male; Nevirapine; Retrospective Studies; Treatment Outcome; Viral Load

2014
Lopinavir/r no longer recommended as a first-line regimen: a comparative effectiveness analysis.
    Journal of the International AIDS Society, 2014, Volume: 17

    Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cohort Studies; Deoxycytidine; Emtricitabine; Female; France; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Organophosphonates; Prospective Studies; Tenofovir; Treatment Failure; Viral Load

2014
Lopinavir/ritonavir plus lamivudine and abacavir or zidovudine dose ratios for paediatric fixed-dose combinations.
    Antiviral therapy, 2015, Volume: 20, Issue:2

    Topics: Administration, Oral; Adolescent; Age Factors; Antiretroviral Therapy, Highly Active; Biological Availability; Child; Child, Preschool; Clinical Trials as Topic; Computer Simulation; Dideoxynucleosides; Drug Combinations; Drug Dosage Calculations; Drug Monitoring; Female; HIV Infections; HIV-1; Humans; Infant; Lamivudine; Lopinavir; Male; Models, Statistical; Ritonavir; Silybin; Silymarin; Viral Load; Zidovudine

2015
Changes in bone mineral density after 96 weeks of treatment with atazanavir/ritonavir or lopinavir/ritonavir plus tenofovir DF/emtricitabine in treatment-naive patients with HIV-1 infection: the CASTLE body composition substudy.
    Journal of acquired immune deficiency syndromes (1999), 2015, Jan-01, Volume: 68, Issue:1

    Topics: Absorptiometry, Photon; Anti-HIV Agents; Atazanavir Sulfate; Body Composition; Bone Density; HIV Infections; HIV-1; Humans; Lopinavir; Multivariate Analysis; Oligopeptides; Pyridines; Ritonavir

2015
Persistent production of an integrase-deleted HIV-1 variant with no resistance mutation and wild-type proviral DNA in a treated patient.
    AIDS research and human retroviruses, 2015, Volume: 31, Issue:1

    Topics: Anti-HIV Agents; Base Sequence; Defective Viruses; DNA, Viral; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Immune Evasion; Integrases; Lamivudine; Leukocytes, Mononuclear; Lopinavir; Molecular Sequence Data; Proviruses; Sequence Analysis, DNA; Sequence Deletion; Viral Load; Zidovudine

2015
Improved serum cholesterol in paediatric patients switched from suppressive lopinavir-based therapy to boosted darunavir or atazanavir: an 18-month retrospective study.
    HIV medicine, 2014, Volume: 15, Issue:10

    Topics: Adolescent; Analysis of Variance; Anti-HIV Agents; Atazanavir Sulfate; Child; Cholesterol; Darunavir; Drug Substitution; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Oligopeptides; Pyridines; Retrospective Studies; Sulfonamides

2014
CYP3A4 polymorphism and lopinavir toxicity in an HIV-infected pregnant woman.
    Clinical drug investigation, 2015, Volume: 35, Issue:1

    Topics: Adult; Cytochrome P-450 CYP3A; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Polymorphism, Single Nucleotide; Pregnancy; Pregnancy Complications, Infectious

2015
Is it time to revise antiretrovirals dosing? a pharmacokinetic viewpoint.
    AIDS (London, England), 2014, Oct-23, Volume: 28, Issue:16

    Topics: Anti-Retroviral Agents; Atazanavir Sulfate; Drug Monitoring; HIV Infections; Humans; Lopinavir; Nevirapine; Oligopeptides; Plasma; Pyridines; Retrospective Studies

2014
Anti-HIV drug-combination nanoparticles enhance plasma drug exposure duration as well as triple-drug combination levels in cells within lymph nodes and blood in primates.
    AIDS research and human retroviruses, 2015, Volume: 31, Issue:1

    Topics: Adenine; Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Carriers; Drug Combinations; HIV Infections; HIV Protease Inhibitors; HIV-1; Indinavir; Lipids; Lopinavir; Lymph Nodes; Macaca; Nanoparticles; Organophosphonates; Ritonavir; Tenofovir; Viral Load; Virus Latency

2015
Barriers to simplified HIV treatment in low-resource settings.
    The Lancet. Infectious diseases, 2014, Volume: 14, Issue:12

    Topics: Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Male; Reverse Transcriptase Inhibitors; Ritonavir

2014
A sudden cardiac death induced by sildenafil and sexual activity in an HIV patient with drug interaction, cardiac early repolarization, and arrhythmogenic right ventricular cardiomyopathy.
    International journal of cardiology, 2015, Jan-20, Volume: 179

    Topics: Anti-Bacterial Agents; Clarithromycin; Death, Sudden, Cardiac; Dideoxynucleosides; Drug Combinations; Drug Interactions; Electrocardiography; Fatal Outcome; HIV Infections; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Piperazines; Purines; Ritonavir; Sexual Behavior; Sildenafil Citrate; Sulfonamides; Vasodilator Agents

2015
Human immunodeficiency virus post-exposure prophylaxis: primum non nocere.
    The American journal of medicine, 2015, Volume: 128, Issue:4

    Topics: Adult; Antiviral Agents; Bipolar Disorder; Cytochrome P-450 CYP3A Inhibitors; Dihydroergotamine; Drug Synergism; Drug Therapy, Combination; Ergotism; Female; HIV Infections; Humans; Hypotension, Orthostatic; Lamivudine; Lopinavir; Post-Exposure Prophylaxis; Ritonavir; Vasoconstrictor Agents; Zidovudine

2015
Monotherapy with boosted PIs as an ART simplification strategy in clinical practice.
    The Journal of antimicrobial chemotherapy, 2015, Volume: 70, Issue:4

    Topics: Adult; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Darunavir; Drug-Related Side Effects and Adverse Reactions; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Retrospective Studies; Ritonavir; Sulfonamides; Survival Analysis; Treatment Outcome; Viral Load

2015
[In Process Citation].
    Enfermedades infecciosas y microbiologia clinica, 2014, Volume: 32 Suppl 3

    Topics: Drug Combinations; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Ritonavir

2014
[Lopinavir/ritonavir in new simplification strategies in antiretroviral therapy].
    Enfermedades infecciosas y microbiologia clinica, 2014, Volume: 32 Suppl 3

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Combinations; HIV Infections; HIV Integrase Inhibitors; HIV Protease Inhibitors; Humans; Lopinavir; Medication Adherence; Meta-Analysis as Topic; Multicenter Studies as Topic; Patient Acceptance of Health Care; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Risk; Ritonavir; Therapeutic Equivalency; Viral Load

2014
[Challenges of lopinavir/ritonavir in the chronicity of human immunodeficiency virus infection].
    Enfermedades infecciosas y microbiologia clinica, 2014, Volume: 32 Suppl 3

    Topics: Aging; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Chronic Disease; Comorbidity; Drug Combinations; Drug Costs; HIV Infections; HIV Integrase Inhibitors; HIV Protease Inhibitors; Humans; Lopinavir; Medication Adherence; Meta-Analysis as Topic; Multicenter Studies as Topic; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Ritonavir

2014
[Positioning of lopinavir/ritonavir in antiretroviral treatment schemes].
    Enfermedades infecciosas y microbiologia clinica, 2014, Volume: 32 Suppl 3

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Combinations; HIV Infections; HIV Integrase Inhibitors; HIV Protease Inhibitors; Humans; Lopinavir; Medication Adherence; Meta-Analysis as Topic; Multicenter Studies as Topic; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Risk; Ritonavir; Therapeutic Equivalency; Viral Load

2014
Boosted lopinavir- versus boosted atazanavir-containing regimens and immunologic, virologic, and clinical outcomes: a prospective study of HIV-infected individuals in high-income countries.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015, Apr-15, Volume: 60, Issue:8

    Topics: Adolescent; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; CD4 Lymphocyte Count; Cohort Studies; Cooperative Behavior; Developed Countries; Europe; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Prospective Studies; Treatment Outcome; United States; Viral Load; Young Adult

2015
A pharmacokinetic model of lopinavir in combination with ritonavir in human.
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2014, Volume: 2014

    Topics: Administration, Oral; Area Under Curve; Drug Therapy, Combination; Half-Life; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Ritonavir

2014
Efficacy of second-line antiretroviral therapy among people living with HIV/AIDS in Asia: results from the TREAT Asia HIV observational database.
    Journal of acquired immune deficiency syndromes (1999), 2015, Feb-01, Volume: 68, Issue:2

    Topics: Adult; Anti-Retroviral Agents; Asia; Atazanavir Sulfate; CD4 Lymphocyte Count; Cohort Studies; Female; Follow-Up Studies; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Oligopeptides; Pyridines; Ritonavir; Survival Analysis; Treatment Failure; Viral Load; Young Adult

2015
Virologic failure among children taking lopinavir/ritonavir-containing first-line antiretroviral therapy in South Africa.
    The Pediatric infectious disease journal, 2015, Volume: 34, Issue:2

    Topics: Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Child, Preschool; Cohort Studies; Drug Resistance, Viral; Female; Genotype; HIV; HIV Infections; Humans; Infant; Lopinavir; Male; Mutation, Missense; Ritonavir; South Africa; Treatment Failure; Viral Load

2015
The effect of malnutrition on the pharmacokinetics and virologic outcomes of lopinavir, efavirenz and nevirapine in food insecure HIV-infected children in Tororo, Uganda.
    The Pediatric infectious disease journal, 2015, Volume: 34, Issue:3

    Topics: Adolescent; Adult; Alkynes; Antiretroviral Therapy, Highly Active; Benzoxazines; Child; Cyclopropanes; HIV Infections; Humans; Lopinavir; Malnutrition; Models, Theoretical; Nevirapine; Poverty; Randomized Controlled Trials as Topic; Treatment Failure; Treatment Outcome; Uganda; Viral Load; Young Adult

2015
Cost-effectiveness of first-line antiretroviral therapy for HIV-infected African children less than 3 years of age.
    AIDS (London, England), 2015, Jun-19, Volume: 29, Issue:10

    Topics: Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Child, Preschool; Clinical Trials as Topic; Cost-Benefit Analysis; Health Care Costs; HIV Infections; Humans; Infant; Infant, Newborn; Life Expectancy; Lopinavir; Male; Nevirapine; Ritonavir; South Africa

2015
Current Efavirenz (EFV) or ritonavir-boosted lopinavir (LPV/r) use correlates with elevate markers of atherosclerosis in HIV-infected subjects in Addis Ababa, Ethiopia.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Adult; Alkynes; Anti-HIV Agents; Atherosclerosis; Benzoxazines; Biomarkers; Blood Pressure; C-Reactive Protein; Carotid Intima-Media Thickness; Case-Control Studies; Cholesterol, HDL; Cholesterol, LDL; Cyclopropanes; Ethiopia; Female; Heart Rate; HIV Infections; HIV-1; Humans; Lipodystrophy; Lopinavir; Male; Middle Aged; Nevirapine; Pulse Wave Analysis; Ritonavir; Triglycerides

2015
Long-term changes in bone mineral density after switching to a protease inhibitor monotherapy in HIV-infected subject.
    The new microbiologica, 2015, Volume: 38, Issue:2

    Topics: Adult; Anti-HIV Agents; Bone Density; Female; Femur; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Longitudinal Studies; Lopinavir; Male; Middle Aged; Ritonavir; Time Factors; Viral Load

2015
Hair concentrations of antiretrovirals predict viral suppression in HIV-infected pregnant and breastfeeding Ugandan women.
    AIDS (London, England), 2015, Apr-24, Volume: 29, Issue:7

    Topics: Adult; Alkynes; Anti-Retroviral Agents; Benzoxazines; Breast Feeding; Chromatography, Liquid; Cohort Studies; Cyclopropanes; Drug Monitoring; Female; Hair; HIV Infections; Humans; Infant; Infant, Newborn; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Randomized Controlled Trials as Topic; Tandem Mass Spectrometry; Treatment Outcome; Uganda; Viral Load

2015
Immunological and Virological Outcomes of Patients Switched from LPV/r to ATV/r-Containing Second- Line Regimens.
    Current HIV research, 2015, Volume: 13, Issue:3

    Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; CD4 Lymphocyte Count; Female; HIV Infections; Hospitals, Teaching; Humans; Lopinavir; Male; Middle Aged; Nigeria; Retrospective Studies; Ritonavir; Treatment Outcome; Viral Load; Young Adult

2015
Fluorometric assay for phenotypic differentiation of drug-resistant HIV mutants.
    Scientific reports, 2015, May-19, Volume: 5

    Topics: Anti-HIV Agents; Chromatography, High Pressure Liquid; Drug Resistance, Viral; Fluorometry; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lopinavir; Microbial Sensitivity Tests; Ritonavir; Saquinavir

2015
[Comparative and evolutionary profile of people infected with HIV on antiretroviral therapy in Kinshasa, Democratic Republic of Congo].
    The Pan African medical journal, 2014, Volume: 19

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Democratic Republic of the Congo; Disease Progression; Drug Combinations; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Ritonavir; Zidovudine

2014
Impact of switching from lopinavir/ritonavir to boosted and un-boosted atazanavir on glucose metabolism: the ATAzanavir & GLUcose metabolism (ATAGLU) study.
    International journal of STD & AIDS, 2016, Volume: 27, Issue:8

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Blood Glucose; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lipid Metabolism; Lopinavir; Middle Aged; Retrospective Studies; Ritonavir; Treatment Outcome; Viral Load

2016
Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome in children.
    Pediatric pulmonology, 2016, Volume: 51, Issue:2

    Topics: Antiretroviral Therapy, Highly Active; Antitubercular Agents; Child; Child, Preschool; Cohort Studies; Female; HIV Infections; HIV Protease Inhibitors; Humans; Immune Reconstitution Inflammatory Syndrome; Infant; Infant, Newborn; Lopinavir; Male; Prospective Studies; Ritonavir; South Africa; Tuberculosis; Tuberculosis, Lymph Node; Tuberculosis, Pulmonary

2016
[Pharmacokinetic profiles of lopinavir (LPV) in Chinese HIV-infected patients].
    Zhonghua nei ke za zhi, 2015, Volume: 54, Issue:5

    Topics: China; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pyrimidinones; Ritonavir

2015
Oral Lopinavir Use and Human Papillomavirus Infection in HIV-Positive Women.
    Journal of acquired immune deficiency syndromes (1999), 2015, Oct-01, Volume: 70, Issue:2

    Topics: Adult; Anti-HIV Agents; Female; HIV Infections; Humans; Lopinavir; Papillomaviridae; Papillomavirus Infections; Uterine Cervical Neoplasms

2015
Factors Associated with the Development of Drug Resistance Mutations in HIV-1 Infected Children Failing Protease Inhibitor-Based Antiretroviral Therapy in South Africa.
    PloS one, 2015, Volume: 10, Issue:7

    Topics: Antiretroviral Therapy, Highly Active; Coinfection; Drug Resistance, Viral; Gene Frequency; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Host-Pathogen Interactions; Humans; Infant; Logistic Models; Lopinavir; Malnutrition; Mutation; Retrospective Studies; Risk Factors; Ritonavir; Time Factors; Tuberculosis

2015
Lopinavir and atazanavir in pregnancy: comparable infant outcomes, virological efficacies and preterm delivery rates.
    HIV medicine, 2016, Volume: 17, Issue:1

    Topics: Adolescent; Adult; Atazanavir Sulfate; Drug Combinations; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Infant; Infant, Newborn; Lopinavir; Middle Aged; Pregnancy; Pregnancy Outcome; Premature Birth; Retrospective Studies; Ritonavir; Treatment Outcome; Viral Load; Young Adult

2016
Using Lopinavir Concentrations in Hair Samples to Assess Treatment Outcomes on Second-Line Regimens Among Asian Children.
    AIDS research and human retroviruses, 2015, Volume: 31, Issue:10

    Topics: Adolescent; Anti-HIV Agents; Asian People; Child; Chromatography, Liquid; Drug Monitoring; Female; Hair; HIV Infections; Humans; Longitudinal Studies; Lopinavir; Male; Medication Adherence; Plasma; Prospective Studies; Tandem Mass Spectrometry; Treatment Outcome

2015
Brief Report: Significant Decreases in Both Total and Unbound Lopinavir and Amprenavir Exposures During Coadministration: ACTG Protocol A5143/A5147s Results.
    Journal of acquired immune deficiency syndromes (1999), 2015, Dec-15, Volume: 70, Issue:5

    Topics: Adult; Anti-HIV Agents; Area Under Curve; Carbamates; Drug Interactions; Drug Therapy, Combination; Female; Furans; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Sulfonamides; Viral Load

2015
Fibroblast growth factor 23: associations with antiretroviral therapy in patients co-infected with HIV and hepatitis C.
    HIV medicine, 2016, Volume: 17, Issue:5

    Topics: Adult; Alkynes; Anti-Retroviral Agents; Bayes Theorem; Benzoxazines; Canada; Coinfection; Cyclopropanes; Dideoxynucleosides; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Hepatitis C; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Prospective Studies; Risk Factors; Tenofovir

2016
Acute Myocarditis and Myopathy as Presenting Manifestations of Human Immunodeficiency Virus Infection.
    The Israel Medical Association journal : IMAJ, 2015, Volume: 17, Issue:8

    Topics: Anti-HIV Agents; Arrhythmias, Cardiac; Autopsy; Coronary Angiography; Creatine Kinase; Deoxycytidine; Drug Combinations; Electrocardiography; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Fatal Outcome; HIV Infections; Humans; Lopinavir; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Muscular Diseases; Myocarditis; Myocardium; Organophosphorus Compounds; Pulmonary Edema; Ritonavir

2015
Long-term efavirenz use is associated with worse neurocognitive functioning in HIV-infected patients.
    Journal of neurovirology, 2016, Volume: 22, Issue:2

    Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cognitive Dysfunction; Coinfection; Cyclopropanes; Drug Therapy, Combination; Executive Function; Female; Hepacivirus; Hepatitis C; HIV Infections; HIV-1; Humans; Lopinavir; Male; Memory; Middle Aged; Neuropsychological Tests; Ritonavir; Verbal Learning

2016
[Boosted protease inhibitor monotherapy in HIV-infected patients: results of a study in a real life setting].
    Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2015, Volume: 28, Issue:5

    Topics: Adult; Aged; Darunavir; Drug Combinations; Drug Resistance, Viral; Female; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Mutation; Retrospective Studies; Ritonavir

2015
Efficacy and HIV drug resistance profile of second-line ART among patients having received long-term first-line regimens in rural China.
    Scientific reports, 2015, Oct-08, Volume: 5

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; China; Drug Resistance, Viral; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Mutation; Prospective Studies; Ritonavir; RNA, Viral; Rural Population; Tenofovir; Treatment Outcome; Viral Load

2015
Antiretroviral Therapy for Nevirapine-Exposed Children With HIV Infection.
    JAMA, 2015, Nov-03, Volume: 314, Issue:17

    Topics: Anti-Retroviral Agents; Benzoxazines; Female; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Lopinavir; Male; Nevirapine

2015
Adherence to Post-Exposure Prophylaxis (PEP) and Incidence of HIV Seroconversion in a Major North American Cohort.
    PloS one, 2015, Volume: 10, Issue:11

    Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Drug Combinations; Emtricitabine; Female; HIV Infections; HIV Seropositivity; Humans; Incidence; Lamivudine; Lopinavir; Male; Medication Adherence; Middle Aged; Post-Exposure Prophylaxis; Quebec; Ritonavir; Tenofovir; Young Adult; Zidovudine

2015
Plasma Mitochondrial DNA Levels as a Biomarker of Lipodystrophy Among HIV-infected Patients Treated with Highly Active Antiretroviral Therapy (HAART).
    Current molecular medicine, 2015, Volume: 15, Issue:10

    Topics: Adult; Alkynes; Antiretroviral Therapy, Highly Active; Benzoxazines; Biomarkers; Case-Control Studies; Cyclopropanes; DNA, Mitochondrial; Drug Combinations; Female; HIV; HIV Infections; Humans; Lamivudine; Lipodystrophy; Lopinavir; Male; Middle Aged; Mitochondria; Nelfinavir; Predictive Value of Tests; Ritonavir; ROC Curve; Stavudine; Zidovudine

2015
Antiretroviral Therapy, Especially Efavirenz, Is Associated with Low Bone Mineral Density in HIV-Infected South Africans.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: Adult; Age Factors; Alkynes; Anti-Retroviral Agents; Benzoxazines; Bone Density; Cross-Sectional Studies; Cyclopropanes; Female; Femur; HIV Infections; Humans; Lopinavir; Lumbar Vertebrae; Male; Radiography; Reverse Transcriptase Inhibitors; South Africa

2015
Cerebrospinal fluid and plasma lopinavir concentrations and viral response in virologically suppressed patients switching to lopinavir/ritonavir monotherapy once daily.
    Antiviral therapy, 2016, Volume: 21, Issue:4

    Topics: Adult; Anti-HIV Agents; Drug Administration Schedule; Drug Combinations; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Pilot Projects; Prospective Studies; Ritonavir; Treatment Failure

2016
HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: Atazanavir Sulfate; Darunavir; Drug Resistance, Viral; Drug Therapy, Combination; Genotyping Techniques; HIV Infections; HIV-1; Humans; Lopinavir; Mutation; Point-of-Care Systems; Protease Inhibitors; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Failure

2015
Lopinavir Resistance Classification with Imbalanced Data Using Probabilistic Neural Networks.
    Journal of medical systems, 2016, Volume: 40, Issue:3

    Topics: Algorithms; Antiviral Agents; Drug Resistance, Viral; HIV Infections; Humans; Logistic Models; Lopinavir; Neural Networks, Computer; Predictive Value of Tests; Software Design

2016
Low Prolactin and High 20-α-Hydroxysteroid Dehydrogenase Levels Contribute to Lower Progesterone Levels in HIV-Infected Pregnant Women Exposed to Protease Inhibitor-Based Combination Antiretroviral Therapy.
    The Journal of infectious diseases, 2016, May-15, Volume: 213, Issue:10

    Topics: 20-alpha-Hydroxysteroid Dehydrogenase; Animals; Anti-HIV Agents; Cells, Cultured; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Lopinavir; Mice; Mice, Inbred C57BL; Placenta; Pregnancy; Pregnancy Complications, Infectious; Progesterone; Prolactin; Ritonavir; Trophoblasts; Zidovudine

2016
Effect of Methamphetamine on Spectral Binding, Ligand Docking and Metabolism of Anti-HIV Drugs with CYP3A4.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Amphetamine-Related Disorders; Atazanavir Sulfate; Catalytic Domain; Cytochrome P-450 CYP3A; Drug Interactions; HIV Infections; HIV Protease Inhibitors; Humans; Inactivation, Metabolic; Lopinavir; Methamphetamine; Microsomes, Liver; Molecular Docking Simulation; Nelfinavir; Protein Binding; Pyridines; Pyrones; Sulfonamides

2016
Drug-drug interactions between bedaquiline and the antiretrovirals lopinavir/ritonavir and nevirapine in HIV-infected patients with drug-resistant TB.
    The Journal of antimicrobial chemotherapy, 2016, Volume: 71, Issue:4

    Topics: Adult; Antitubercular Agents; Diarylquinolines; Drug Combinations; Drug Interactions; Drug Monitoring; Female; HIV Infections; Humans; Lopinavir; Male; Nevirapine; Ritonavir; Time Factors; Tuberculosis, Multidrug-Resistant; Young Adult

2016
Maternal and foetal outcomes among 4118 women with HIV infection treated with lopinavir/ritonavir during pregnancy: analysis of population-based surveillance data from the national study of HIV in pregnancy and childhood in the United Kingdom and Ireland.
    BMC infectious diseases, 2016, Feb-04, Volume: 16

    Topics: Adult; Anti-HIV Agents; Female; HIV Infections; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Ireland; Lopinavir; Population Surveillance; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Ritonavir; United Kingdom

2016
Elevated adiponectin prevents HIV protease inhibitor toxicity and preserves cerebrovascular homeostasis in mice.
    Biochimica et biophysica acta, 2016, Volume: 1862, Issue:6

    Topics: Adiponectin; Animals; Blood-Brain Barrier; Brain; Brain Injuries; Cognition; HIV Infections; HIV Protease Inhibitors; Homeostasis; Lopinavir; Male; Mice; Mice, Inbred C57BL; Ritonavir; Up-Regulation

2016
Comparison of Population Pharmacokinetics Based on Steady-State Assumption Versus Electronically Monitored Adherence to Lopinavir, Atazanavir, Efavirenz, and Etravirine: A Retrospective Study.
    Therapeutic drug monitoring, 2016, Volume: 38, Issue:4

    Topics: Alkynes; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Drug Monitoring; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Medication Adherence; Nitriles; Pyridazines; Pyrimidines; Retrospective Studies; Reverse Transcriptase Inhibitors

2016
Heme oxygenase-1-derived bilirubin counteracts HIV protease inhibitor-mediated endothelial cell dysfunction.
    Free radical biology & medicine, 2016, Volume: 94

    Topics: Acetylcysteine; Atazanavir Sulfate; Bilirubin; Cardiovascular Diseases; Cell Proliferation; Endothelial Cells; Gene Expression Regulation; Heme Oxygenase-1; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; NF-E2-Related Factor 2; Promoter Regions, Genetic; Reactive Oxygen Species; Ritonavir; Rotenone

2016
Evaluation of pharmacokinetic interactions between long-acting HIV-1 fusion inhibitor albuvirtide and lopinavir/ritonavir, in HIV-infected subjects, combined with clinical study and simulation results.
    Xenobiotica; the fate of foreign compounds in biological systems, 2017, Volume: 47, Issue:2

    Topics: Anti-HIV Agents; Drug Interactions; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Maleimides; Peptides; Ritonavir

2017
Model-Based Analysis of Unbound Lopinavir Pharmacokinetics in HIV-Infected Pregnant Women Supports Standard Dosing in the Third Trimester.
    CPT: pharmacometrics & systems pharmacology, 2016, Volume: 5, Issue:3

    Topics: Adolescent; Adult; Algorithms; Computer Simulation; Drug Combinations; Drug Dosage Calculations; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, Third; Ritonavir; Young Adult

2016
Differences in genetic variants in lopinavir disposition among HIV-infected Bantu Africans.
    Pharmacogenomics, 2016, Volume: 17, Issue:7

    Topics: Adult; Anti-HIV Agents; Black People; Cross-Sectional Studies; Cytochrome P-450 CYP3A; Ethnicity; Female; HIV Infections; Humans; Liver-Specific Organic Anion Transporter 1; Lopinavir; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Young Adult

2016
Editorial Commentary: Neurocognitive Performance in Ritonavir-boosted Protease Inhibitor Monotherapy.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016, 07-15, Volume: 63, Issue:2

    Topics: HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Ritonavir

2016
Long-term clinical experience with darunavir (2007-2015) in a large cohort of HIV-infected patients in Spain.
    Journal of medical virology, 2016, Volume: 88, Issue:12

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Darunavir; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Long Term Adverse Effects; Lopinavir; Male; Retrospective Studies; Ritonavir; RNA, Viral; Spain; Sulfonamides; Viral Load; Young Adult

2016
Estimated Glomerular Filtration Rate Trajectories in HIV-Infected Subjects Treated With Different Ritonavir-Boosted Protease Inhibitors and Tenofovir Disoproxil Fumarate or Abacavir.
    Medicine, 2016, Volume: 95, Issue:22

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Comorbidity; Dideoxynucleosides; Drug Therapy, Combination; Emtricitabine; Female; Glomerular Filtration Rate; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Retrospective Studies; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Viral Load

2016
Efavirenz and ritonavir-boosted lopinavir use exhibited elevated markers of atherosclerosis across age groups in people living with HIV in Ethiopia.
    Journal of biomechanics, 2016, 09-06, Volume: 49, Issue:13

    Topics: Adolescent; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atherosclerosis; Benzoxazines; Biomarkers; Carotid Intima-Media Thickness; Child; Cyclopropanes; Ethiopia; Female; HIV Infections; Humans; Lipids; Lopinavir; Male; Middle Aged; Pulse Wave Analysis; Ritonavir; Young Adult

2016
Pharmaceutical Equivalence of Distributed Generic Antiretroviral (ARV) in Asian Settings: The Cross-Sectional Surveillance Study - PEDA Study.
    PloS one, 2016, Volume: 11, Issue:6

    Topics: Anti-HIV Agents; Anti-Retroviral Agents; Developing Countries; Drugs, Generic; HIV Infections; Humans; Lopinavir; Ritonavir; Thailand; Vietnam

2016
Random lopinavir concentrations predict resistance on lopinavir-based antiretroviral therapy.
    International journal of antimicrobial agents, 2016, Volume: 48, Issue:2

    Topics: Adolescent; Adult; Anti-HIV Agents; Child; Child, Preschool; Cross-Sectional Studies; Diagnosis, Differential; Drug Resistance, Viral; Female; HIV Infections; Humans; Infant; Lopinavir; Male; Medication Adherence; Middle Aged; Plasma; South Africa; Treatment Failure; Young Adult

2016
HIV-1 Coinfection Does Not Reduce Exposure to Rifampin, Isoniazid, and Pyrazinamide in South African Tuberculosis Outpatients.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:10

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Antitubercular Agents; Area Under Curve; Biological Availability; Coinfection; Female; HIV Infections; HIV-1; Humans; Isoniazid; Lopinavir; Male; Models, Statistical; Mycobacterium tuberculosis; Outpatients; Prospective Studies; Pyrazinamide; Rifampin; Ritonavir; South Africa; Tuberculosis, Pulmonary

2016
Impact of protease inhibitors on the evolution of urinary markers: Subanalyses from an observational cross-sectional study.
    Medicine, 2016, Volume: 95, Issue:32

    Topics: Acute Kidney Injury; Adult; Albuminuria; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Biomarkers; Cross-Sectional Studies; Darunavir; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Proteinuria; Ritonavir

2016
Switching to boosted protease inhibitor plus a second antiretroviral drug (dual therapy) for treatment simplification: a multicenter observational study.
    BMC infectious diseases, 2016, Aug-11, Volume: 16, Issue:1

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Darunavir; Drug Therapy, Combination; Female; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Lopinavir; Male; Medication Adherence; Middle Aged; Proportional Hazards Models; Raltegravir Potassium; Retrospective Studies; Risk; Tenofovir

2016
Effect of Lopinavir and Nevirapine Concentrations on Viral Outcomes in Protease Inhibitor-experienced HIV-infected Children.
    The Pediatric infectious disease journal, 2016, Volume: 35, Issue:12

    Topics: Child, Preschool; Drug Monitoring; HIV Infections; HIV Protease Inhibitors; Humans; Infant; Lopinavir; Nevirapine; Treatment Outcome; Viral Load; Viremia

2016
Hyperlipidaemia in HIV-infected patients on lopinavir/ritonavir monotherapy in resource-limited settings.
    Antiviral therapy, 2017, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Aged; Biomarkers; CD4 Lymphocyte Count; Clinical Trials as Topic; Developing Countries; Female; HIV Infections; HIV Protease Inhibitors; Humans; Hyperlipidemias; Incidence; Lipids; Lopinavir; Male; Middle Aged; Multicenter Studies as Topic; Risk Factors; Ritonavir; Viral Load; Young Adult

2017
Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies.
    Nature communications, 2016, 10-21, Volume: 7

    Topics: Administration, Oral; Animals; Anti-HIV Agents; Caco-2 Cells; Cell Membrane Permeability; Child; Drug Delivery Systems; High-Throughput Screening Assays; HIV Infections; Humans; Lopinavir; Male; Nanomedicine; Nanoparticles; Rats; Rats, Sprague-Dawley; Ritonavir; Small Molecule Libraries; Translational Research, Biomedical

2016
[Darunavir/cobicistat monotherapy. Experience in a tertiary hospital].
    Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2016, Volume: 29, Issue:6

    Topics: Adult; Cobicistat; Darunavir; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Prospective Studies; Ritonavir; Tertiary Care Centers; Treatment Outcome; Viral Load

2016
miR-34a is a common link in both HIV- and antiretroviral therapy-induced vascular aging.
    Aging, 2016, 11-26, Volume: 8, Issue:12

    Topics: Aging; Animals; Anti-Retroviral Agents; Arteriosclerosis Obliterans; Cellular Senescence; Drug Combinations; Gene Expression Regulation; HIV Infections; Humans; Lopinavir; Male; Mice; Mice, Knockout; Mice, Transgenic; MicroRNAs; Myocytes, Smooth Muscle; Ritonavir; tat Gene Products, Human Immunodeficiency Virus

2016
Are Prophylactic and Therapeutic Target Concentrations Different?: the Case of Lopinavir-Ritonavir or Lamivudine Administered to Infants for Prevention of Mother-to-Child HIV-1 Transmission during Breastfeeding.
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:2

    Topics: Anti-HIV Agents; Bayes Theorem; Breast Feeding; HIV Infections; Humans; Infant; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Mothers; Ritonavir

2017
Wide variation in susceptibility of transmitted/founder HIV-1 subtype C Isolates to protease inhibitors and association with in vitro replication efficiency.
    Scientific reports, 2016, 11-30, Volume: 6

    Topics: Atazanavir Sulfate; Darunavir; DNA Replication; Drug Resistance, Viral; gag Gene Products, Human Immunodeficiency Virus; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Microbial Sensitivity Tests; Virus Replication; Zambia

2016
Initiatives to challenge patent barriers and their relationship with the price of medicines procured by the Brazilian Unified National Health System.
    Cadernos de saude publica, 2016, Dec-01, Volume: 32, Issue:11

    Topics: Anti-HIV Agents; Brazil; Drug Costs; Government Programs; HIV Infections; Humans; Longitudinal Studies; Lopinavir; Patents as Topic; Ritonavir

2016
Early antiretroviral treatment (eART) limits viral diversity over time in a long-term HIV viral suppressed perinatally infected child.
    BMC infectious diseases, 2016, Dec-09, Volume: 16, Issue:1

    Topics: Anti-HIV Agents; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Infant; Infant, Newborn; Lamivudine; Lopinavir; Male; Nevirapine; Phylogeny; Ritonavir; Zidovudine

2016
From antiretroviral therapy access to provision of third line regimens: evidence of HIV Drug resistance mutations to first and second line regimens among Ugandan adults.
    BMC research notes, 2016, Dec-23, Volume: 9, Issue:1

    Topics: Adolescent; Adult; Anti-HIV Agents; Atazanavir Sulfate; Cross-Sectional Studies; Darunavir; Drug Resistance, Viral; Female; Genotype; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Mutation; Prospective Studies; Uganda; Young Adult

2016
Confirming model-predicted pharmacokinetic interactions between bedaquiline and lopinavir/ritonavir or nevirapine in patients with HIV and drug-resistant tuberculosis.
    International journal of antimicrobial agents, 2017, Volume: 49, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Antitubercular Agents; Diarylquinolines; Drug Interactions; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Nevirapine; Ritonavir; Tuberculosis, Multidrug-Resistant; Young Adult

2017
Improved kidney function in patients who switch their protease inhibitor from atazanavir or lopinavir to darunavir.
    AIDS (London, England), 2017, 02-20, Volume: 31, Issue:4

    Topics: Adult; Atazanavir Sulfate; Cohort Studies; Cytochrome P-450 CYP3A Inhibitors; Darunavir; Female; Glomerular Filtration Rate; HIV Infections; HIV Protease Inhibitors; Humans; Kidney Diseases; Lopinavir; Male; Middle Aged; Treatment Outcome; United Kingdom

2017
Refining criteria for selecting candidates for a safe lopinavir/ritonavir or darunavir/ritonavir monotherapy in HIV-infected virologically suppressed patients.
    PloS one, 2017, Volume: 12, Issue:2

    Topics: Adult; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cohort Studies; Darunavir; Drug Therapy, Combination; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Kaplan-Meier Estimate; Lopinavir; Male; Middle Aged; Outcome Assessment, Health Care; Proportional Hazards Models; Ritonavir; RNA, Viral; Viral Load; Viremia; Young Adult

2017
First-line antiretroviral drug discontinuations in children.
    PloS one, 2017, Volume: 12, Issue:2

    Topics: Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; Child; Child, Preschool; Cyclopropanes; Dideoxynucleosides; Drug Combinations; Follow-Up Studies; HIV; HIV Infections; Humans; Infant; Kaplan-Meier Estimate; Lopinavir; Outcome Assessment, Health Care; Proportional Hazards Models; Ritonavir; South Africa; Stavudine; Withholding Treatment; Zidovudine

2017
[Toxicity for warfarine switching from lopinavir/ritonavir to dolutegravir].
    Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria, 2017, 03-01, Volume: 41, Issue:2

    Topics: Anti-HIV Agents; Anticoagulants; Aortic Valve Stenosis; Female; Heterocyclic Compounds, 3-Ring; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Middle Aged; Mitral Valve Insufficiency; Oxazines; Piperazines; Pyridones; Ritonavir; Warfarin

2017
Kaletra lower-strength pediatric tablet approved in Europe.
    AIDS patient care and STDs, 2008, Volume: 22, Issue:5

    Topics: Anti-HIV Agents; Child; Child, Preschool; Drug Approval; Drug Therapy, Combination; Europe; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir; Tablets

2008
Toxic lopinavir concentrations in an HIV-1 infected patient taking herbal medications.
    AIDS (London, England), 2008, Jun-19, Volume: 22, Issue:10

    Topics: Diarrhea; Drug-Related Side Effects and Adverse Reactions; Herb-Drug Interactions; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones

2008
Acute meningoencephalitis in chronic HIV infection: clinical resolution with lopinavir-ritonavir-containing therapy.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2008, Jun-15, Volume: 46, Issue:12

    Topics: Adult; Cerebrospinal Fluid; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Meningoencephalitis; Pyrimidinones; Ritonavir; RNA, Viral; Treatment Outcome; Viral Load

2008
FDA notifications. FDA approves half-strength Kaletra.
    AIDS alert, 2008, Volume: 23, Issue:1

    Topics: HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; United States; United States Food and Drug Administration

2008
Lack of evidence for an effect of lopinavir/ritonavir on tenofovir renal clearance.
    Clinical pharmacology and therapeutics, 2008, Volume: 84, Issue:6

    Topics: Adenine; Creatinine; Drug Interactions; Drug Therapy, Combination; Female; Glomerular Filtration Rate; HIV Infections; HIV Protease Inhibitors; Humans; Kidney Tubules; Lopinavir; Male; Organophosphonates; Pyrimidinones; Ritonavir; Sensitivity and Specificity; Tenofovir

2008
Influence of antiretroviral drugs on the pharmacokinetics of prednisolone in HIV-infected individuals.
    Journal of acquired immune deficiency syndromes (1999), 2008, Aug-15, Volume: 48, Issue:5

    Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Interactions; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Prednisolone; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir

2008
Anti-HIV agents. Lopinavir and ritonavir (Kaletra) tablets get tested.
    TreatmentUpdate, 2008, Volume: 20, Issue:2

    Topics: Chemistry, Pharmaceutical; Drug Administration Schedule; HIV Infections; HIV Protease Inhibitors; Lipids; Lopinavir; Pyrimidinones; Ritonavir; Tablets

2008
Time to virological failure with atazanavir/ritonavir and lopinavir/ritonavir, with or without an H2-receptor blocker, not significantly different in HIV observational database study.
    International journal of STD & AIDS, 2008, Volume: 19, Issue:8

    Topics: Anti-HIV Agents; Atazanavir Sulfate; Databases, Factual; Drug Interactions; Drug Therapy, Combination; Female; Histamine H2 Antagonists; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Medical Audit; Multivariate Analysis; Oligopeptides; Pyridines; Pyrimidinones; Ritonavir; RNA, Viral; Time Factors; Treatment Failure; Treatment Outcome; Viral Load

2008
Noninferiority and lopinavir/ritonavir monotherapy trials.
    AIDS (London, England), 2008, Aug-20, Volume: 22, Issue:13

    Topics: Clinical Trials as Topic; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir; Treatment Outcome

2008
Virologic response to lopinavir-ritonavir-based antiretroviral regimens in a multicenter international clinical cohort: comparison of genotypic interpretation scores.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:11

    Topics: Adolescent; Adult; Aged; Cohort Studies; Drug Resistance, Viral; Female; Genes, Viral; Genotype; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Mutation; Pyrimidinones; Retrospective Studies; Ritonavir; Young Adult

2008
FDA notifications. Lopinavir/ritonavir label updated.
    AIDS alert, 2008, Volume: 23, Issue:8

    Topics: Adolescent; Child; Drug Labeling; HIV Infections; Humans; Infant; Infant, Newborn; Lopinavir; Pyrimidinones; United States; United States Food and Drug Administration

2008
Trough concentrations of lopinavir, nelfinavir, and nevirapine with standard dosing in human immunodeficiency virus-infected pregnant women receiving 3-drug combination regimens.
    Therapeutic drug monitoring, 2008, Volume: 30, Issue:5

    Topics: Adolescent; Adult; Antiretroviral Therapy, Highly Active; Cohort Studies; Drug Therapy, Combination; Female; HIV Infections; Humans; Lopinavir; Nelfinavir; Nevirapine; Pregnancy; Pregnancy Complications, Infectious; Pyrimidinones; Viral Load; Young Adult

2008
Initial treatment of HIV-1 infection.
    The New England journal of medicine, 2008, Aug-28, Volume: 359, Issue:9

    Topics: Alkynes; Benzoxazines; Cause of Death; Cyclopropanes; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir

2008
Two cases of multidrug-resistant human immunodeficiency virus infection treated with atazanavir and lopinavir/ritonavir combination therapy.
    Journal of Korean medical science, 2008, Volume: 23, Issue:4

    Topics: Adult; Atazanavir Sulfate; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Oligopeptides; Pyridines; Pyrimidinones; Ritonavir

2008
Initial treatment of HIV-1 infection.
    The New England journal of medicine, 2008, Aug-28, Volume: 359, Issue:9

    Topics: Alkynes; Anti-Retroviral Agents; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Lopinavir; Pyrimidinones; Ritonavir; RNA, Viral; Treatment Failure

2008
The pharmacokinetics and pharmacogenomics of efavirenz and lopinavir/ritonavir in HIV-infected persons requiring hemodialysis.
    AIDS (London, England), 2008, Oct-01, Volume: 22, Issue:15

    Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Kidney Failure, Chronic; Lopinavir; Male; Middle Aged; Polymorphism, Single Nucleotide; Prospective Studies; Pyrimidinones; Renal Dialysis; Reverse Transcriptase Inhibitors; Ritonavir

2008
Women and non-whites new to HAART respond similarly to men and whites.
    AIDS patient care and STDs, 2008, Volume: 22, Issue:9

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Ethnicity; Female; HIV Infections; Humans; Lopinavir; Male; Pyrimidinones; Randomized Controlled Trials as Topic; Retrospective Studies; Sex Factors

2008
Natural polymorphisms in HIV-1 protease: impact on effectiveness of a first-line lopinavir-containing antiretroviral therapy regimen.
    Journal of medical virology, 2008, Volume: 80, Issue:11

    Topics: Adult; Amino Acid Substitution; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Resistance, Viral; Female; HIV Infections; HIV Protease; HIV-1; Humans; Lopinavir; Male; Middle Aged; Mutation, Missense; Polymorphism, Genetic; Pyrimidinones; Treatment Outcome; Viral Load

2008
Two-year outcomes of children on non-nucleoside reverse transcriptase inhibitor and protease inhibitor regimens in a South African pediatric antiretroviral program.
    The Pediatric infectious disease journal, 2008, Volume: 27, Issue:11

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Child; Child, Preschool; Cohort Studies; Didanosine; Female; HIV Infections; HIV Protease Inhibitors; Humans; Infant; Lamivudine; Lopinavir; Male; Multivariate Analysis; Pyrimidinones; Retrospective Studies; Reverse Transcriptase Inhibitors; Ritonavir; South Africa; Stavudine; Treatment Outcome; Zidovudine

2008
Biomarker discovery using targeted maximum-likelihood estimation: application to the treatment of antiretroviral-resistant HIV infection.
    Statistics in medicine, 2009, Jan-15, Volume: 28, Issue:1

    Topics: Anti-HIV Agents; Biomarkers; Drug Resistance, Viral; Genotype; HIV Infections; HIV-1; Humans; Likelihood Functions; Lopinavir; Pyrimidinones

2009
Correlation between HIV-1 RNA load in blood and seminal plasma depending on antiretroviral treatment status, regimen and penetration of semen by antiretroviral drugs.
    Current HIV research, 2008, Volume: 6, Issue:5

    Topics: Adult; Antiviral Agents; Atazanavir Sulfate; Blood; Chromatography, High Pressure Liquid; Cohort Studies; Cross-Sectional Studies; HIV Infections; HIV-1; Humans; Longitudinal Studies; Lopinavir; Male; Middle Aged; Nevirapine; Oligopeptides; Plasma; Pyridines; Pyrimidinones; RNA, Viral; Semen; Statistics as Topic; Viral Load

2008
Improved tolerability and quality of life with the new lopinavir/ritonavir tablet formulation.
    The Journal of infection, 2008, Volume: 57, Issue:6

    Topics: Administration, Oral; Anti-HIV Agents; HIV Infections; Humans; Lopinavir; Pyrimidinones; Quality of Life; Ritonavir

2008
HIV postexposure prophylaxis after sexual assault: why is it so hard to accomplish?
    Sexually transmitted diseases, 2008, Volume: 35, Issue:12

    Topics: Adolescent; Animals; Anti-HIV Agents; Drug Combinations; Drug Therapy, Combination; Female; HIV Infections; Humans; Lamivudine; Lopinavir; Macaca mulatta; Pyrimidinones; Sex Offenses; Zidovudine

2008
Switching to darunavir/ritonavir achieves viral suppression in patients with persistent low replication on first-line lopinavir/ritonavir.
    AIDS (London, England), 2008, Nov-12, Volume: 22, Issue:17

    Topics: Darunavir; Drug Interactions; Drug Resistance, Viral; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pyrimidinones; Ritonavir; Sulfonamides; Virus Replication

2008
Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2008, Dec-15, Volume: 47, Issue:12

    Topics: Adult; Cushing Syndrome; Drug Interactions; HIV Infections; HIV-1; Humans; Iatrogenic Disease; Lopinavir; Male; Pyrimidinones; Ritonavir; Triamcinolone

2008
[A case of acquired encephalopathy in a child. A cause that we thought had disappeared].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2008, Volume: 15, Issue:12

    Topics: AIDS Dementia Complex; Anti-HIV Agents; Anti-Infective Agents; Drug Therapy, Combination; Female; Fluconazole; HIV Infections; HIV Protease Inhibitors; HIV Seropositivity; HIV-1; Humans; Infant; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Polymerase Chain Reaction; Pyrimidinones; Reverse Transcriptase Inhibitors; RNA, Viral; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination; Zidovudine

2008
Multiple-dose pharmacokinetic behavior of elvucitabine, a nucleoside reverse transcriptase inhibitor, administered over 21 days with lopinavir-ritonavir in human immunodeficiency virus type 1-infected subjects.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:2

    Topics: Anti-HIV Agents; Area Under Curve; Biological Availability; Cohort Studies; Drug Combinations; Half-Life; HIV Infections; HIV-1; Humans; Lopinavir; Models, Statistical; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Zalcitabine

2009
[Preserving future therapy options. Darunavir--the protease inhibitor for various patient groups].
    MMW Fortschritte der Medizin, 2008, Apr-28, Volume: 150 Spec No 1

    Topics: Acquired Immunodeficiency Syndrome; CD4 Lymphocyte Count; Clinical Trials as Topic; Darunavir; Drug Resistance, Multiple; Drug Resistance, Viral; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pyrimidinones; Sulfonamides; Viral Load

2008
HIV protease inhibitors inhibit the development of preerythrocytic-stage plasmodium parasites.
    The Journal of infectious diseases, 2009, Jan-01, Volume: 199, Issue:1

    Topics: Animals; Anopheles; Female; HIV Infections; HIV Protease Inhibitors; Lopinavir; Malaria; Mice; Plasmodium; Plasmodium berghei; Plasmodium yoelii; Pyrimidinones; Ritonavir

2009
96-week CASTLE data show similar efficacy results.
    AIDS patient care and STDs, 2008, Volume: 22, Issue:11

    Topics: Adenine; Anti-HIV Agents; Atazanavir Sulfate; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV-1; Humans; Lopinavir; Multicenter Studies as Topic; Oligopeptides; Organophosphonates; Pyridines; Pyrimidinones; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Treatment Outcome; Viral Load

2008
[From research to clinical practice: use of lopinavir/ritonavir in monotherapy].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26, Issue:10

    Topics: Adult; Biomedical Research; CD4 Lymphocyte Count; Clinical Medicine; Drug Evaluation; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Viral Load

2008
Head-to-head comparison of two first-line regimens and an NRTI-sparing regimen for initial therapy of HIV-1 infection: what should we start?
    Current HIV/AIDS reports, 2009, Volume: 6, Issue:1

    Topics: Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Clinical Trials, Phase III as Topic; Cyclopropanes; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Pyrimidinones; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Treatment Outcome

2009
Protease inhibitor levels in hair strongly predict virologic response to treatment.
    AIDS (London, England), 2009, Feb-20, Volume: 23, Issue:4

    Topics: Adult; Atazanavir Sulfate; CD4 Lymphocyte Count; Drug Monitoring; Epidemiologic Methods; Female; Hair; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Middle Aged; Oligopeptides; Patient Compliance; Pyridines; Pyrimidinones; Ritonavir; Specimen Handling; Treatment Outcome; Viral Load

2009
Pharmacokinetics of lopinavir in HIV type-1-infected children taking the new tablet formulation once daily.
    Antiviral therapy, 2008, Volume: 13, Issue:8

    Topics: Adolescent; Anti-HIV Agents; Area Under Curve; Child; Child, Preschool; Drug Administration Schedule; Female; Half-Life; HIV Infections; HIV-1; Humans; Lopinavir; Male; Pyrimidinones; Tablets

2008
ABCB1 polymorphisms and the concentrations of lopinavir and ritonavir in blood, semen and saliva of HIV-infected men under antiretroviral therapy.
    Pharmacogenomics, 2009, Volume: 10, Issue:2

    Topics: Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Genotype; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Pyrimidinones; Ritonavir; Saliva; Semen

2009
Cost-effectiveness analysis of lopinavir/ritonavir and atazanavir+ritonavir regimens in the CASTLE study.
    Advances in therapy, 2009, Volume: 26, Issue:2

    Topics: Anti-HIV Agents; Atazanavir Sulfate; Budgets; CD4 Lymphocyte Count; Coronary Disease; Cost Savings; Cost-Benefit Analysis; Decision Support Techniques; Drug Costs; Drug Therapy, Combination; HIV Infections; Humans; Life Expectancy; Lopinavir; Markov Chains; Models, Econometric; Oligopeptides; Pyridines; Pyrimidinones; Quality-Adjusted Life Years; Ritonavir; Smoking; United States

2009
More Kaletra monotherapy results.
    Project Inform perspective, 2008, Issue:47

    Topics: HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Viral Load

2008
[Atazanavir-induced nephrolithiasis].
    Enfermedades infecciosas y microbiologia clinica, 2009, Volume: 27, Issue:2

    Topics: Adenine; Adult; Alkynes; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Dideoxynucleosides; Hepatitis B, Chronic; Hepatitis C, Chronic; Hepatitis D, Chronic; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Lopinavir; Male; Nephrolithiasis; Oligopeptides; Organophosphonates; Pyridines; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Stavudine; Tenofovir

2009
Comparison of Markov model and discrete-event simulation techniques for HIV.
    PharmacoEconomics, 2009, Volume: 27, Issue:2

    Topics: Computer Simulation; Cost-Benefit Analysis; Drug Combinations; Economics, Pharmaceutical; Health Care Costs; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Markov Chains; Models, Econometric; Models, Statistical; Pyrimidinones; Ritonavir

2009
Population pharmacokinetics of lopinavir predict suboptimal therapeutic concentrations in treatment-experienced human immunodeficiency virus-infected children.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:6

    Topics: Adolescent; Child; Child, Preschool; Female; HIV Infections; HIV Protease Inhibitors; Humans; Linear Models; Lopinavir; Male; Models, Biological; Monte Carlo Method; Probability; Prospective Studies; Pyrimidinones

2009
Civil society strategy for the compulsory licensing of lopinavir/ritonavir: the Brazilian case.
    HIV/AIDS policy & law review, 2008, Volume: 13, Issue:2-3

    Topics: Brazil; Drug Approval; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir

2008
Mitochondrial function, morphology and metabolic parameters improve after switching from stavudine to a tenofovir-containing regimen.
    The Journal of antimicrobial chemotherapy, 2009, Volume: 63, Issue:6

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenine; Adipose Tissue; Adult; Anti-HIV Agents; Body Fat Distribution; CD4 Lymphocyte Count; Deoxyguanosine; F2-Isoprostanes; Glutathione; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Lamivudine; Lopinavir; Male; Mitochondria; Organophosphonates; Pyrimidinones; Ritonavir; Stavudine; Tenofovir; Treatment Outcome; Viral Load

2009
Good response to lopinavir/ritonavir-containing antiretroviral regimens in antiretroviral-naive HIV-2-infected patients.
    AIDS (London, England), 2009, Jun-01, Volume: 23, Issue:9

    Topics: Adult; CD4 Lymphocyte Count; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-2; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; Treatment Outcome

2009
Clinical experience with the combined use of lopinavir/ritonavir and rifampicin.
    AIDS (London, England), 2009, Apr-27, Volume: 23, Issue:7

    Topics: Adult; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Pyrimidinones; Rifampin; Ritonavir; Viral Load

2009
FDA approves three generics.
    AIDS patient care and STDs, 2009, Volume: 23, Issue:4

    Topics: Adenine; Anti-HIV Agents; Drug Approval; Drugs, Generic; HIV Infections; Humans; Lamivudine; Lopinavir; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; United States; United States Food and Drug Administration

2009
Population analysis of the pregnancy-related modifications in lopinavir pharmacokinetics and their possible consequences for dose adjustment.
    The Journal of antimicrobial chemotherapy, 2009, Volume: 63, Issue:6

    Topics: Anti-HIV Agents; Chromatography, High Pressure Liquid; Female; HIV Infections; Humans; Lopinavir; Metabolic Clearance Rate; Monte Carlo Method; Plasma; Pregnancy; Pyrimidinones; Tissue Distribution

2009
Does HIV-1 subtype D have a higher risk of vertical transmission than other HIV subtypes?
    The Journal of infectious diseases, 2009, May-15, Volume: 199, Issue:10

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Female; HIV Infections; HIV-1; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Pyrimidinones; Risk Factors; Survival Rate; Viral Load; Young Adult

2009
Virological response to highly active antiretroviral therapy in patients infected with human immunodeficiency virus type 2 (HIV-2) and in patients dually infected with HIV-1 and HIV-2 in the Gambia and emergence of drug-resistant variants.
    Journal of clinical microbiology, 2009, Volume: 47, Issue:7

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Resistance, Viral; Female; Gambia; HIV Infections; HIV Protease; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Lamivudine; Longitudinal Studies; Lopinavir; Male; Middle Aged; Molecular Sequence Data; Mutation, Missense; Pyrimidinones; Ritonavir; Sequence Analysis, DNA; Treatment Outcome; Viral Load; Zidovudine

2009
Risk factors for loss of virological suppression in patients receiving lopinavir/ritonavir monotherapy for maintenance of HIV suppression.
    Antiviral therapy, 2009, Volume: 14, Issue:2

    Topics: Adult; CD4 Lymphocyte Count; Female; Hemoglobins; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Medication Adherence; Middle Aged; Pyrimidinones; Risk Factors; Ritonavir; RNA, Viral

2009
Safety and efficacy of a double-boosted protease inhibitor combination, saquinavir and lopinavir/ritonavir, in pretreated children at 96 weeks.
    Antiviral therapy, 2009, Volume: 14, Issue:2

    Topics: Adolescent; Child; Drug Administration Schedule; Drug Monitoring; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Hypercholesterolemia; Lopinavir; Male; Pyrimidinones; Ritonavir; Saquinavir; Thailand; Treatment Outcome

2009
Pregnancy outcomes in women with HIV type-1 receiving a lopinavir/ritonavir-containing regimen.
    Antiviral therapy, 2009, Volume: 14, Issue:3

    Topics: Adult; Cohort Studies; Drug Therapy, Combination; Female; France; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Obstetric Labor, Premature; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Pyrimidinones; Ritonavir

2009
Two studies show Kaletra and Isentress similarly suppress HIV, yet have different side effects.
    Project Inform perspective, 2009, Issue:48

    Topics: CD4 Lymphocyte Count; HIV; HIV Infections; HIV Integrase Inhibitors; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Pyrrolidinones; Raltegravir Potassium; Viral Load

2009
Prezista fares better than Kaletra in first line therapy.
    Project Inform perspective, 2009, Issue:48

    Topics: Adult; CD4 Lymphocyte Count; Darunavir; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Pyrimidinones; Sulfonamides; Viral Load

2009
Successful absorption of antiretroviral drugs after gastrojejunal bypass surgery following failure of therapy through a jejunal tube.
    Internal medicine (Tokyo, Japan), 2009, Volume: 48, Issue:12

    Topics: Administration, Oral; Adult; Anti-Retroviral Agents; Duodenal Neoplasms; Gastric Bypass; HIV Infections; Humans; Intestinal Absorption; Jejunum; Lopinavir; Lymphoma; Male; Pyrimidinones

2009
Report from the 16th Conference on Retroviruses and Opportunistic Infections. Lopinavir/r is superior to nevirapine in women who previously received single-dose nevirapine.
    Journal watch. AIDS clinical care, 2009, Volume: 21, Issue:4

    Topics: Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Nevirapine; Pyrimidinones; Reverse Transcriptase Inhibitors

2009
[Lopinavir/ritonavir monotherapy in the treatment of HIV infection. Introduction].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 16

    Topics: Drug Combinations; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir

2008
Effect of human immunodeficiency virus type 1 protease inhibitor therapy and subtype on development of resistance in subtypes B and G.
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2010, Volume: 10, Issue:3

    Topics: Amino Acid Substitution; Drug Resistance, Viral; Genetic Variation; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lopinavir; Phylogeny; Pyrimidinones; Selection, Genetic; Sequence Analysis, Protein

2010
Differences in lopinavir plasma concentrations comparing Kaletra film coated tablets and soft gelatine capsules that result in various lipid abnormalities.
    Drug metabolism letters, 2009, Volume: 3, Issue:2

    Topics: Adult; Capsules; Cholesterol; Cholesterol, HDL; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Retrospective Studies; Ritonavir; Tablets; Triglycerides

2009
Failure of treatment with first-line lopinavir boosted with ritonavir can be explained by novel resistance pathways with protease mutation 76V.
    The Journal of infectious diseases, 2009, Sep-01, Volume: 200, Issue:5

    Topics: Amino Acid Sequence; Amino Acid Substitution; Anti-HIV Agents; DNA Mutational Analysis; Drug Resistance, Viral; gag Gene Products, Human Immunodeficiency Virus; HIV; HIV Infections; HIV Protease; Humans; Longitudinal Studies; Lopinavir; Molecular Sequence Data; Mutation, Missense; Phylogeny; Pyrimidinones; Ritonavir; Sequence Analysis, DNA; Sequence Homology; Treatment Failure; Virus Replication

2009
Pharmacokinetic interactions between rifabutin and lopinavir/ritonavir in HIV-infected patients with mycobacterial co-infection.
    The Journal of antimicrobial chemotherapy, 2009, Volume: 64, Issue:4

    Topics: Adult; Anti-HIV Agents; Antitubercular Agents; Female; HIV Infections; Humans; Lopinavir; Male; Pyrimidinones; Rifabutin; Ritonavir; Serum; Tuberculosis; Young Adult

2009
Atazanavir: new indication. First-line treatment: fewer gastrointestinal disorders but more cases of jaundice and a risk of torsades de pointes.
    Prescrire international, 2009, Volume: 18, Issue:101

    Topics: Anti-HIV Agents; Anti-Retroviral Agents; Atazanavir Sulfate; Drug Approval; Drug Therapy, Combination; Europe; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Jaundice; Lopinavir; Oligopeptides; Pyridines; Pyrimidinones; Randomized Controlled Trials as Topic; Ritonavir; Torsades de Pointes; Viral Load

2009
Transient cardiac arrhythmias related to lopinavir/ritonavir in two patients with HIV infection.
    Sexual health, 2009, Volume: 6, Issue:3

    Topics: Adult; Anti-HIV Agents; Arrhythmias, Cardiac; Electrocardiography; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir

2009
[Regimen simplification: lopinavir/ritonavir with or without efavirenz].
    Enfermedades infecciosas y microbiologia clinica, 2009, Volume: 27, Issue:9

    Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; HIV Infections; Humans; Lopinavir; Pyrimidinones; Ritonavir; Treatment Outcome; Viral Load; Viremia

2009
Response to the comparison of generic ritonavir (Ritomune, Cipla) and lopinavir/ritonavir tablets (Lopimune, Cipla) and the Abbott brand (Norvir soft-gel capsules and Kaletra tablets).
    Journal of pharmaceutical sciences, 2010, Volume: 99, Issue:2

    Topics: Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biological Availability; Chemistry, Pharmaceutical; Dogs; Drug Combinations; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir; Solubility; Tablets; Therapeutic Equivalency

2010
HIV protease inhibitors induce endoplasmic reticulum stress and disrupt barrier integrity in intestinal epithelial cells.
    Gastroenterology, 2010, Volume: 138, Issue:1

    Topics: Animals; Apoptosis; Carbamates; Cell Line; Cell Membrane Permeability; Endoplasmic Reticulum; Furans; HIV Infections; HIV Protease Inhibitors; Intestinal Mucosa; Lopinavir; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Pyrimidinones; Ritonavir; Stress, Physiological; Sulfonamides; Transcription Factor CHOP

2010
Re: Acknowledgement of human bioequivalency of matrix's lopinavir-ritonavir formulation to Kaletra, comment to article on Bioavailability of generic ritonavir and lopinavir/ritonavir tablet products in a dog model, by Garren et al.
    Journal of pharmaceutical sciences, 2010, Volume: 99, Issue:2

    Topics: Animals; Anti-HIV Agents; Biological Availability; Chemistry, Pharmaceutical; Data Interpretation, Statistical; Dogs; Drug Combinations; Drug Evaluation, Preclinical; Food-Drug Interactions; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Models, Biological; Pyrimidinones; Ritonavir; Tablets; Therapeutic Equivalency

2010
Impact of first-line protease inhibitors on predicted resistance to tipranavir in HIV-1-infected patients with virological failure.
    BMC infectious diseases, 2009, Sep-14, Volume: 9

    Topics: Adult; Atazanavir Sulfate; DNA Mutational Analysis; Drug Resistance, Viral; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Oligopeptides; Pyridines; Pyrimidinones; Pyrones; Ritonavir; RNA, Viral; Sulfonamides; Treatment Failure; Young Adult

2009
Paralytic ileus possibly associated with interaction between ritonavir/lopinavir and vincristine.
    Pharmacy world & science : PWS, 2009, Volume: 31, Issue:6

    Topics: Abdominal Pain; Adult; Antineoplastic Agents, Phytogenic; Burkitt Lymphoma; Constipation; Drug Interactions; HIV Infections; HIV Protease Inhibitors; Humans; Intestinal Pseudo-Obstruction; Lopinavir; Male; Pyrimidinones; Ritonavir; Vincristine

2009
Bilateral pedal edema in an HIV patient: Lopinavir/Ritonavir-containing treatment regimen as a potential cause?
    Journal of infection in developing countries, 2009, Jun-01, Volume: 3, Issue:5

    Topics: Anti-HIV Agents; Edema; HIV Infections; Humans; Leg; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; Uganda

2009
[Medication change due to side effects or possible long-term complications. Side effect management with vision].
    MMW Fortschritte der Medizin, 2009, Apr-30, Volume: 151, Issue:18

    Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Deoxycytidine; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; HIV-1; Humans; Long-Term Care; Lopinavir; Oligopeptides; Organophosphonates; Oxazines; Pyridines; Pyrimidinones; Pyrrolidinones; Raltegravir Potassium; Randomized Controlled Trials as Topic

2009
High rates of survival, immune reconstitution, and virologic suppression on second-line antiretroviral therapy in South Africa.
    Journal of acquired immune deficiency syndromes (1999), 2010, Apr-01, Volume: 53, Issue:4

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Didanosine; Female; HIV Infections; Humans; Lopinavir; Male; Pyrimidinones; Ritonavir; South Africa; Survival Analysis; Treatment Outcome; Viral Load; Zidovudine

2010
Serial knife stabbings with HIV exposure--implications for post-exposure prophylaxis.
    The Journal of infection, 2010, Volume: 60, Issue:1

    Topics: Anti-HIV Agents; Crime Victims; Disease Transmission, Infectious; Drug Combinations; Hepatitis B; Hepatitis C; HIV Infections; Humans; Lamivudine; Lopinavir; Post-Exposure Prophylaxis; Pyrimidinones; Viral Load; Wounds, Stab; Zidovudine

2010
Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients.
    Pharmacogenomics, 2009, Volume: 10, Issue:10

    Topics: Adult; Alleles; Black People; Female; Gene Frequency; Genotype; HIV Infections; HIV Protease Inhibitors; Humans; Leukocytes, Mononuclear; Lopinavir; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Pilot Projects; Polymorphism, Genetic; Pyrimidinones; White People

2009
Therapeutic drug monitoring of lopinavir in human immunodeficiency virus-infected children receiving adult tablets.
    The Pediatric infectious disease journal, 2010, Volume: 29, Issue:1

    Topics: Adolescent; Child; Drug Monitoring; HIV Infections; Humans; Lopinavir; Pyrimidinones; Serum; Tablets

2010
Factors influencing lopinavir and atazanavir plasma concentration.
    The Journal of antimicrobial chemotherapy, 2010, Volume: 65, Issue:1

    Topics: Adult; Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Body Weight; Cyclopropanes; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Oligopeptides; Plasma; Pyridines; Pyrimidinones; Rifabutin; United Kingdom

2010
A population analysis of weight-related differences in lopinavir pharmacokinetics and possible consequences for protease inhibitor-naive and -experienced patients.
    Antiviral therapy, 2009, Volume: 14, Issue:7

    Topics: Adolescent; Adult; Aged; Body Weight; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Models, Statistical; Population Surveillance; Pyrimidinones; Tablets

2009
Impact of reduced dosing of lopinavir/ritonavir in virologically controlled HIV-infected patients: the Kaledose trial.
    The Journal of antimicrobial chemotherapy, 2010, Volume: 65, Issue:1

    Topics: Adult; Anti-HIV Agents; DNA, Viral; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Lipids; Lopinavir; Male; Middle Aged; Proviruses; Pyrimidinones; Ritonavir; Viral Load; Young Adult

2010
Transplacental transfer of antiretroviral drugs and newborn birth weight in HIV-infected pregnant women.
    Current HIV research, 2009, Volume: 7, Issue:6

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Apgar Score; Atazanavir Sulfate; Birth Weight; Female; Gestational Age; HIV Infections; Humans; Infant, Newborn; Lopinavir; Maternal-Fetal Exchange; Nelfinavir; Nevirapine; Oligopeptides; Placenta; Pregnancy; Pregnancy Complications, Infectious; Pyridines; Pyrimidinones

2009
Analysis of CYP3A4-HIV-1 protease drugs interactions by computational methods for Highly Active Antiretroviral Therapy in HIV/AIDS.
    Journal of molecular graphics & modelling, 2010, Volume: 28, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Antiretroviral Therapy, Highly Active; Computational Biology; Cytochrome P-450 CYP3A; Darunavir; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lopinavir; Nelfinavir; Pyridines; Pyrimidinones; Pyrones; Ritonavir; Sulfonamides

2010
Drug-drug interaction between itraconazole and the protease inhibitor lopinavir/ritonavir.
    The Annals of pharmacotherapy, 2009, Volume: 43, Issue:12

    Topics: Adult; Antifungal Agents; Drug Combinations; Drug Interactions; Drug Monitoring; Histoplasmosis; HIV Infections; HIV Protease Inhibitors; Humans; Itraconazole; Lopinavir; Male; Pyrimidinones; Ritonavir

2009
Pharmacogenomic adaptation of antiretroviral therapy: overcoming the failure of lopinavir in an African infant with CYP2D6 ultrarapid metabolism.
    European journal of clinical pharmacology, 2010, Volume: 66, Issue:1

    Topics: Antiretroviral Therapy, Highly Active; Black People; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Female; Genotype; HIV Infections; Humans; Infant; Lopinavir; Pharmacogenetics; Polymorphism, Genetic; Pyrimidinones; Ritonavir; Treatment Failure

2010
The SWITCHMRK studies: substitution of lopinavir/ritonavir with raltegravir in HIV-positive individuals.
    Expert review of anti-infective therapy, 2009, Volume: 7, Issue:10

    Topics: HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Pyrrolidinones; Raltegravir Potassium; Randomized Controlled Trials as Topic; Treatment Outcome; Viral Load

2009
Lopinavir protein binding in HIV-1-infected pregnant women.
    HIV medicine, 2010, Volume: 11, Issue:4

    Topics: Acute-Phase Proteins; Adolescent; Adult; Antiretroviral Therapy, Highly Active; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, Third; Prospective Studies; Protein Binding; Pyrimidinones; Ritonavir; Young Adult

2010
Combination antiretroviral drugs in PLGA nanoparticle for HIV-1.
    BMC infectious diseases, 2009, Dec-09, Volume: 9

    Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Carriers; Drug Combinations; Drug Compounding; HIV Infections; Humans; Lactic Acid; Lopinavir; Macrophages; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Pyrimidinones; Ritonavir

2009
Treatment modification in human immunodeficiency virus-infected individuals starting combination antiretroviral therapy between 2005 and 2008.
    Archives of internal medicine, 2010, Jan-11, Volume: 170, Issue:1

    Topics: Adenine; Adult; AIDS-Related Opportunistic Infections; Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Deoxycytidine; Dideoxynucleosides; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Nevirapine; Oligopeptides; Organophosphonates; Proportional Hazards Models; Prospective Studies; Pyridines; Pyrimidinones; Risk Factors; Switzerland; Tenofovir; Zidovudine

2010
DAART for human immunodeficiency virus-infected patients: Studying subjects not at risk for nonadherence and use of untested interventions.
    Archives of internal medicine, 2010, Jan-11, Volume: 170, Issue:1

    Topics: Adenine; Administration, Oral; Adolescent; Adult; Aged; Anti-HIV Agents; Deoxycytidine; Dose-Response Relationship, Drug; Drug Resistance, Viral; Emtricitabine; Female; Genotype; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Organophosphonates; Patient Compliance; Pyrimidinones; Randomized Controlled Trials as Topic; RNA, Viral; Stavudine; Tenofovir; Treatment Outcome; Young Adult

2010
The impact of SLCO1B1 polymorphisms on the plasma concentration of lopinavir and ritonavir in HIV-infected men.
    British journal of clinical pharmacology, 2010, Volume: 69, Issue:1

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Chromatography, Liquid; Gene Frequency; Genotype; HIV Infections; Humans; Liver-Specific Organic Anion Transporter 1; Lopinavir; Male; Organic Anion Transporters; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Pyrimidinones; Ritonavir; Tandem Mass Spectrometry

2010
Comment on: Pharmacokinetics and 48 week efficacy of low-dose lopinavir/ritonavir in HIV-infected children.
    The Journal of antimicrobial chemotherapy, 2010, Volume: 65, Issue:4

    Topics: Anti-HIV Agents; Child; Child, Preschool; HIV Infections; Humans; Lopinavir; Pyrimidinones; Ritonavir; Treatment Outcome

2010
Relationship between plasma protease inhibitor concentrations and lipid elevations in HIV patients on a double-boosted protease inhibitor regimen (saquinavir/lopinavir/ritonavir).
    Journal of clinical pharmacology, 2010, Volume: 50, Issue:4

    Topics: Adult; Clinical Trials as Topic; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Hyperlipidemias; Lipids; Lopinavir; Male; Middle Aged; Pilot Projects; Prospective Studies; Pyrimidinones; Retrospective Studies; Ritonavir; Saquinavir

2010
The evolution of protease mutation 76V is associated with protease mutation 46I and gag mutation 431V.
    AIDS (London, England), 2010, Mar-13, Volume: 24, Issue:5

    Topics: Drug Resistance, Viral; Evolution, Molecular; Female; gag Gene Products, Human Immunodeficiency Virus; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Molecular Sequence Data; Mutation; pol Gene Products, Human Immunodeficiency Virus; Pyrimidinones; Sequence Analysis, DNA

2010
The effect of acid reduction with a proton pump inhibitor on the pharmacokinetics of lopinavir or ritonavir in HIV-infected patients on lopinavir/ritonavir-based therapy.
    Journal of clinical pharmacology, 2010, Volume: 50, Issue:9

    Topics: Adult; Antiretroviral Therapy, Highly Active; Drug Interactions; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Omeprazole; Proton Pump Inhibitors; Pyrimidinones; Ritonavir; Young Adult

2010
Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir.
    AIDS (London, England), 2010, May-15, Volume: 24, Issue:8

    Topics: Adolescent; Adult; Aged; Alkynes; Atazanavir Sulfate; Atovaquone; Benzoxazines; Cyclopropanes; Drug Administration Schedule; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Oligopeptides; Proguanil; Pyridines; Pyrimidinones; Ritonavir; Young Adult

2010
Association between lipodystrophy and leptin in human immunodeficiency virus-1-infected children receiving lopinavir/ritonavir-based therapy.
    The Pediatric infectious disease journal, 2010, Volume: 29, Issue:8

    Topics: Adolescent; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biomarkers; Child; Child, Preschool; HIV Infections; HIV-1; HIV-Associated Lipodystrophy Syndrome; Humans; Infant; Leptin; Lopinavir; Prospective Studies; Pyrimidinones; Ritonavir

2010
Accurate ensemble molecular dynamics binding free energy ranking of multidrug-resistant HIV-1 proteases.
    Journal of chemical information and modeling, 2010, May-24, Volume: 50, Issue:5

    Topics: Anti-HIV Agents; Drug Resistance, Multiple; Drug Resistance, Viral; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Molecular Dynamics Simulation; Pyrimidinones; Thermodynamics

2010
Cerebrospinal fluid HIV-1 virological escape with lymphocytic meningitis under lopinavir/ritonavir monotherapy.
    AIDS (London, England), 2010, May-15, Volume: 24, Issue:8

    Topics: HIV Infections; HIV-1; Humans; Lopinavir; Meningitis, Viral; Pyrimidinones; Ritonavir

2010
Syndrome of inappropriate antidiuretic hormone associated with lopinavir therapy.
    The Pediatric infectious disease journal, 2010, Volume: 29, Issue:7

    Topics: Adolescent; Anti-HIV Agents; HIV Infections; Humans; Inappropriate ADH Syndrome; Lopinavir; Male; Pyrimidinones

2010
Extended release tacrolimus and antiretroviral therapy in a renal transplant recipient: so extended!
    Transplant international : official journal of the European Society for Organ Transplantation, 2010, Volume: 23, Issue:10

    Topics: Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Delayed-Action Preparations; HIV Infections; Humans; Immunosuppressive Agents; Kidney Transplantation; Lopinavir; Male; Middle Aged; Pyrimidinones; Tacrolimus

2010
Population pharmacokinetics of lopinavir in combination with rifampicin-based antitubercular treatment in HIV-infected South African children.
    European journal of clinical pharmacology, 2010, Volume: 66, Issue:10

    Topics: AIDS-Related Opportunistic Infections; Anti-HIV Agents; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Infant; Lopinavir; Male; Pyrimidinones; Rifampin; Ritonavir; South Africa; Time Factors; Treatment Outcome; Tuberculosis, Pulmonary

2010
Age-related changes in plasma concentrations of the HIV protease inhibitor lopinavir.
    AIDS research and human retroviruses, 2010, Volume: 26, Issue:6

    Topics: Adolescent; Adult; Age Factors; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Plasma; Pyrimidinones; Young Adult

2010
Once-daily dosing of lopinavir/ritonavir (Kaletra) receives FDA approval.
    AIDS patient care and STDs, 2010, Volume: 24, Issue:6

    Topics: Anti-HIV Agents; Drug Approval; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pyrimidinones; United States; United States Food and Drug Administration

2010
FDA notifications. FDA approves new dosing for Kaletra.
    AIDS alert, 2010, Volume: 25, Issue:6

    Topics: Drug Approval; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; United States; United States Food and Drug Administration

2010
Ultra-fast analysis of plasma and intracellular levels of HIV protease inhibitors in children: a clinical application of MALDI mass spectrometry.
    PloS one, 2010, Jul-01, Volume: 5, Issue:7

    Topics: Adolescent; Child; Chromatography, High Pressure Liquid; HIV Infections; HIV Protease Inhibitors; Humans; Leukocytes, Mononuclear; Lopinavir; Pyrimidinones; Ritonavir; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2010
FDA notifications. Kaletra revisions to packaging approved.
    AIDS alert, 2010, Volume: 25, Issue:3

    Topics: Drug Interactions; Drug Labeling; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; United States; United States Food and Drug Administration

2010
Ultrafast and high-throughput mass spectrometric assay for therapeutic drug monitoring of antiretroviral drugs in pediatric HIV-1 infection applying dried blood spots.
    Analytical and bioanalytical chemistry, 2010, Volume: 398, Issue:1

    Topics: Blood Specimen Collection; Case-Control Studies; Child; Chromatography, High Pressure Liquid; Drug Monitoring; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pyrimidinones; Ritonavir; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2010
Lopinavir tablet pharmacokinetics with an increased dose during pregnancy.
    Journal of acquired immune deficiency syndromes (1999), 2010, Volume: 54, Issue:4

    Topics: Adult; Anti-HIV Agents; Area Under Curve; Body Weight; Cohort Studies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ethnicity; Female; Gestational Age; HIV Infections; Humans; Lopinavir; Postpartum Period; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Pyrimidinones; Racial Groups; Zidovudine

2010
Pharmacokinetic interactions between buprenorphine/naloxone and once-daily lopinavir/ritonavir.
    Journal of acquired immune deficiency syndromes (1999), 2010, Volume: 54, Issue:5

    Topics: Adult; Analgesics, Opioid; Anti-HIV Agents; Buprenorphine; Drug Interactions; Female; HIV Infections; Humans; Lopinavir; Male; Metabolic Clearance Rate; Middle Aged; Naloxone; Pyrimidinones; Ritonavir

2010
Tolerability of HIV postexposure prophylaxis with tenofovir/emtricitabine and lopinavir/ritonavir tablet formulation.
    AIDS (London, England), 2010, Sep-24, Volume: 24, Issue:15

    Topics: Adenine; Adolescent; Adult; Antiviral Agents; CD4 Lymphocyte Count; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Organophosphonates; Post-Exposure Prophylaxis; Practice Guidelines as Topic; Pyrimidinones; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome; Young Adult

2010
A comparison of the long-term durability of nevirapine, efavirenz and lopinavir in routine clinical practice in Europe: a EuroSIDA study.
    HIV medicine, 2011, Volume: 12, Issue:5

    Topics: Alkynes; Argentina; Benzoxazines; Cyclopropanes; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Europe; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Israel; Lopinavir; Male; Nevirapine; Prospective Studies; Pyrimidinones; Reverse Transcriptase Inhibitors; Treatment Outcome; Viral Load

2011
Impact of hepatitis C and liver fibrosis on antiretroviral plasma drug concentrations in HIV-HCV co-infected patients: the HEPADOSE study.
    The Journal of antimicrobial chemotherapy, 2010, Volume: 65, Issue:11

    Topics: Adult; Aged; Alkynes; Anti-Retroviral Agents; Benzoxazines; Case-Control Studies; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Cyclopropanes; Dideoxynucleosides; Female; Hepatitis C, Chronic; HIV Infections; Humans; Liver Cirrhosis; Lopinavir; Male; Middle Aged; Plasma; Pyrimidinones

2010
Incorrect attribution of cerebrospinal fluid HIV-1 virological escape and lymphocytic meningitis to lopinavir/ritonavir monotherapy.
    AIDS (London, England), 2010, Sep-24, Volume: 24, Issue:15

    Topics: HIV Infections; HIV-1; Humans; Lopinavir; Meningitis, Viral; Pyrimidinones; Ritonavir

2010
[Two cases of Fanconi's syndrome induced by tenofovir in the Ivory Coast].
    Medecine et maladies infectieuses, 2011, Volume: 41, Issue:2

    Topics: Adenine; Aged; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cote d'Ivoire; Cyclopropanes; Drug Therapy, Combination; Enterobacter aerogenes; Enterobacteriaceae Infections; Fanconi Syndrome; Female; HIV Infections; HIV-1; Humans; Lamivudine; Lopinavir; Malaria; Male; Middle Aged; Organophosphonates; Pyelonephritis; Pyrimidinones; Ritonavir; Tenofovir

2011
Lipid and lipoprotein profile in HIV-infected patients treated with lopinavir/ritonavir as a component of the first combination antiretroviral therapy.
    AIDS research and human retroviruses, 2011, Volume: 27, Issue:5

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cardiovascular Diseases; Female; HIV Infections; Humans; Lipids; Lipoproteins; Lopinavir; Male; Middle Aged; Pyrimidinones; Retrospective Studies; Risk Assessment; Ritonavir

2011
Assessing the impact of hepatitis C virus coinfection on lopinavir/ritonavir trough concentrations in HIV-infected patients.
    European journal of clinical pharmacology, 2011, Volume: 67, Issue:2

    Topics: Adult; Female; Hepacivirus; Hepatitis C, Chronic; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Liver Cirrhosis; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; Viral Load

2011
Premature senescence of vascular cells is induced by HIV protease inhibitors: implication of prelamin A and reversion by statin.
    Arteriosclerosis, thrombosis, and vascular biology, 2010, Volume: 30, Issue:12

    Topics: Acetylcysteine; Adult; Antioxidants; Case-Control Studies; Cell Proliferation; Cells, Cultured; Cellular Senescence; Coronary Vessels; Cyclin-Dependent Kinase Inhibitor p21; Drug Therapy, Combination; Endothelial Cells; Farnesyltranstransferase; HIV Infections; HIV Protease Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lamin Type A; Lopinavir; Metalloporphyrins; Methionine; Middle Aged; Nuclear Proteins; Oxidative Stress; Paris; Pravastatin; Protein Precursors; Pyrimidinones; Ritonavir; Time Factors; Tumor Suppressor Protein p53

2010
Metabolic and neurologic consequences of chronic lopinavir/ritonavir administration to C57BL/6 mice.
    Antiviral research, 2010, Volume: 88, Issue:3

    Topics: Animals; Cognition; Drug Administration Schedule; Drug Combinations; HIV; HIV Infections; HIV Protease Inhibitors; Lopinavir; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Motor Activity; Pyrimidinones; Ritonavir; Weight Loss

2010
Low rate of virological failure and maintenance of susceptibility to HIV-1 protease inhibitors with first-line lopinavir/ritonavir-based antiretroviral treatment in clinical practice.
    Journal of medical virology, 2010, Volume: 82, Issue:12

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Survival Analysis; Treatment Failure; Treatment Outcome; Viral Load

2010
Diagnosing and responding to violations in the positivity assumption.
    Statistical methods in medical research, 2012, Volume: 21, Issue:1

    Topics: Anti-HIV Agents; Bias; Biomedical Research; Cohort Studies; Computer Simulation; Confounding Factors, Epidemiologic; Data Interpretation, Statistical; Drug Resistance, Viral; HIV Infections; Humans; Lopinavir; Models, Statistical; Mutation; Treatment Outcome

2012
Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients?
    Antiviral therapy, 2010, Volume: 15, Issue:7

    Topics: Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Case-Control Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Dextromethorphan; Digoxin; Down-Regulation; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Midazolam; Middle Aged; Pyrimidinones; Ritonavir; Young Adult

2010
Genetic diversity of HIV type 1 in Montenegro.
    AIDS research and human retroviruses, 2011, Volume: 27, Issue:8

    Topics: Adult; Antiretroviral Therapy, Highly Active; Base Sequence; Drug Resistance, Viral; Female; Genetic Variation; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV Reverse Transcriptase; HIV-1; Humans; Lopinavir; Male; Middle Aged; Molecular Sequence Data; Montenegro; Nelfinavir; Phylogeny; Population Surveillance

2011
Monoboosted lopinavir/ritonavir as simplified second-line maintenance therapy in virologically suppressed children.
    AIDS (London, England), 2011, Jan-28, Volume: 25, Issue:3

    Topics: Adolescent; Antiretroviral Therapy, Highly Active; Child; Drug Administration Schedule; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Pyrimidinones; Ritonavir; RNA, Viral; Thailand

2011
Impact of switching from lopinavir/ritonavir to atazanavir/ritonavir on body fat redistribution in virologically suppressed HIV-infected adults.
    AIDS research and human retroviruses, 2011, Volume: 27, Issue:10

    Topics: Absorptiometry, Photon; Adipose Tissue; Adult; Aged; Anti-HIV Agents; Atazanavir Sulfate; Body Fat Distribution; Body Mass Index; Female; HIV Infections; HIV-1; HIV-Associated Lipodystrophy Syndrome; Humans; Lopinavir; Male; Middle Aged; Oligopeptides; Prospective Studies; Pyridines; Ritonavir; Young Adult

2011
Cost effectiveness of darunavir/ritonavir 600/100 mg bid in treatment-experienced, lopinavir-naive, protease inhibitor-resistant, HIV-infected adults in Belgium, Italy, Sweden and the UK.
    PharmacoEconomics, 2010, Volume: 28 Suppl 1

    Topics: Adult; Antiretroviral Therapy, Highly Active; Belgium; CD4 Lymphocyte Count; Clinical Trials, Phase II as Topic; Cost-Benefit Analysis; Darunavir; Drug Resistance, Viral; Female; Health Care Costs; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Italy; Lopinavir; Male; Markov Chains; Multicenter Studies as Topic; Pyrimidinones; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Ritonavir; RNA, Viral; Sulfonamides; Sweden; United Kingdom; Viral Load

2010
Adherence to HIV therapeutic drug monitoring guidelines in The Netherlands.
    Therapeutic drug monitoring, 2011, Volume: 33, Issue:1

    Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Female; Guideline Adherence; HIV Infections; Humans; Lopinavir; Netherlands; Nevirapine; Pregnancy; Pyrimidinones; Randomized Controlled Trials as Topic

2011
Aminotransferase serum levels decrease after initiating antiretroviral treatment in HIV infected patients.
    Current HIV research, 2011, Volume: 9, Issue:1

    Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Combinations; Female; HIV Infections; Humans; Lamivudine; Longitudinal Studies; Lopinavir; Male; Pyrimidinones; Ritonavir; Serum; Transaminases; Zidovudine

2011
Cost-effectiveness of atazanavir/ritonavir compared with lopinavir/ritonavir in treatment-naïve human immunodeficiency virus-1 patients in Sweden.
    Scandinavian journal of infectious diseases, 2011, Volume: 43, Issue:4

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Clinical Trials as Topic; Cost-Benefit Analysis; HIV Infections; HIV-1; Humans; Lopinavir; Models, Statistical; Oligopeptides; Pyridines; Pyrimidinones; Quality-Adjusted Life Years; Ritonavir; Sweden

2011
Inappropriate claim of 'failure of ritonavir-boosted lopinavir monotherapy in HIV' in the Monotherapy Switzerland/Thailand (MOST) trial.
    AIDS (London, England), 2011, Jan-28, Volume: 25, Issue:3

    Topics: Drug Therapy, Combination; HIV Infections; Humans; Lopinavir; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir

2011
Low lopinavir plasma or hair concentrations explain second-line protease inhibitor failures in a resource-limited setting.
    Journal of acquired immune deficiency syndromes (1999), 2011, Volume: 56, Issue:4

    Topics: Adult; Anti-HIV Agents; Case-Control Studies; Cross-Sectional Studies; Drug Resistance, Viral; Female; Hair; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Plasma; Pyrimidinones; RNA, Viral; South Africa; Treatment Failure; Viral Load

2011
Lack of effect from a previous single dose of nevirapine on virologic and immunologic responses after 6 months of antiretroviral regimens containing either efavirenz or lopinavir-ritonavir.
    Pharmacotherapy, 2011, Volume: 31, Issue:2

    Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Clinical Trials, Phase II as Topic; Cyclopropanes; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; HIV; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Lopinavir; Nevirapine; Pyrimidinones; Randomized Controlled Trials as Topic; Retrospective Studies; Ritonavir; RNA, Viral; South Africa; Young Adult

2011
Patent watch: Indian patent office rejects HIV drug formulation patent.
    Nature reviews. Drug discovery, 2011, Volume: 10, Issue:2

    Topics: Anti-HIV Agents; Chemistry, Pharmaceutical; HIV Infections; Humans; India; Lopinavir; Patents as Topic; Pyrimidinones

2011
Cost effectiveness of atazanavir-ritonavir versus lopinavir-ritonavir in treatment-naïve human immunodeficiency virus-infected patients in the United States.
    Journal of medical economics, 2011, Volume: 14, Issue:2

    Topics: Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; CD4 Lymphocyte Count; Cost-Benefit Analysis; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Markov Chains; Oligopeptides; Organophosphonates; Pyridines; Pyrimidinones; Quality-Adjusted Life Years; Reverse Transcriptase Inhibitors; Risk Assessment; Ritonavir; Tenofovir; United States

2011
First-line antiretroviral therapy after single-dose nevirapine exposure in South Africa: a cost-effectiveness analysis of the OCTANE trial.
    AIDS (London, England), 2011, Feb-20, Volume: 25, Issue:4

    Topics: Adult; Anti-HIV Agents; Cost-Benefit Analysis; Female; HIV Infections; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Life Expectancy; Lopinavir; Male; Nevirapine; Pregnancy; Pyrimidinones; Ritonavir; South Africa; Treatment Outcome

2011
[Ritonavir-boosted lopinavir monotherapy due to intolerance to nucleoside reverse transcriptase inhibitors in an HIV-infected paediatric patient].
    Enfermedades infecciosas y microbiologia clinica, 2011, Volume: 29, Issue:4

    Topics: Adolescent; Anti-HIV Agents; Child Behavior Disorders; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Gastrointestinal Diseases; HIV Infections; HIV Protease Inhibitors; HIV Reverse Transcriptase; Humans; Kidney Calculi; Lopinavir; Male; Mutation, Missense; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir

2011
Rapid development of antiretroviral drug resistance mutations in HIV-infected children less than two years of age initiating protease inhibitor-based therapy in South Africa.
    AIDS research and human retroviruses, 2011, Volume: 27, Issue:9

    Topics: Amino Acid Substitution; Antiretroviral Therapy, Highly Active; Cohort Studies; Drug Resistance, Viral; Female; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Infant; Lopinavir; Male; Mutation, Missense; Nevirapine; pol Gene Products, Human Immunodeficiency Virus; Ritonavir; RNA, Viral; Sequence Analysis, DNA; South Africa; Viral Load

2011
[LC-MS/MS method for simultaneous quantification of lopinavir and ritonavir in human plasma].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2010, Volume: 45, Issue:2

    Topics: Chromatography, Liquid; HIV Infections; Humans; Lopinavir; Ritonavir; Sensitivity and Specificity; Tandem Mass Spectrometry

2010
Utility of therapeutic drug monitoring in the management of HIV-infected pregnant women in receipt of lopinavir.
    International journal of STD & AIDS, 2011, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Anti-HIV Agents; Drug Monitoring; Female; HIV Infections; Humans; Lopinavir; Plasma; Pregnancy; Pregnancy Complications, Infectious; Pyrimidinones; Retrospective Studies; Treatment Outcome; United Kingdom; Young Adult

2011
Total and unbound lopinavir concentrations in the female genital tract of HIV-1 infected women during pregnancy.
    AIDS (London, England), 2011, Mar-13, Volume: 25, Issue:5

    Topics: Female; Genitalia, Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Pyrimidinones; Virus Shedding

2011
Extreme bradycardia due to multiple drug-drug interactions in a patient with HIV post-exposure prophylaxis containing lopinavir-ritonavir.
    British journal of clinical pharmacology, 2011, Volume: 71, Issue:4

    Topics: Bradycardia; Drug Interactions; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Post-Exposure Prophylaxis; Pyrimidinones; Ritonavir

2011
Appearance of a single amino acid insertion at position 33 in HIV type 1 protease under a lopinavir-containing regimen, associated with reduced protease inhibitor susceptibility.
    AIDS research and human retroviruses, 2011, Volume: 27, Issue:11

    Topics: Amino Acid Sequence; Anti-HIV Agents; Base Sequence; Drug Resistance, Viral; HEK293 Cells; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Microbial Sensitivity Tests; Molecular Sequence Data; Mutagenesis, Insertional; Sequence Analysis, DNA; Virus Replication

2011
Lopinavir/ritonavir-based antiretroviral therapy in human immunodeficiency virus type 1-infected naive children: rare protease inhibitor resistance mutations but high lamivudine/emtricitabine resistance at the time of virologic failure.
    The Pediatric infectious disease journal, 2011, Volume: 30, Issue:8

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Child; Child, Preschool; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Female; HIV Infections; HIV Protease; HIV-1; Humans; Infant; Lamivudine; Lopinavir; Male; Mutation; Paris; Pyrimidinones; Ritonavir; Treatment Failure

2011
[Simplification to lopinavir/ritonavir monotherapy in HIV-infected children].
    Anales de pediatria (Barcelona, Spain : 2003), 2011, Volume: 75, Issue:1

    Topics: Adolescent; Child; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Retrospective Studies; Ritonavir

2011
Trial in youngest group points to HIV treatment overhaul.
    Nature medicine, 2011, Volume: 17, Issue:4

    Topics: Anti-HIV Agents; Clinical Trials as Topic; Female; HIV Infections; HIV Protease Inhibitors; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Lopinavir; Nevirapine; Pregnancy; Pregnancy Complications, Infectious; Pyrimidinones; Reverse Transcriptase Inhibitors

2011
Thai HIV-1-infected women do not require a dose increase of lopinavir/ritonavir during the third trimester of pregnancy.
    AIDS (London, England), 2011, Jun-19, Volume: 25, Issue:10

    Topics: Adult; Antiretroviral Therapy, Highly Active; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; HIV Infections; HIV-1; Humans; Infectious Disease Transmission, Vertical; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Pregnancy Trimester, Third; Pyrimidinones; Ritonavir; RNA, Viral; Viral Load

2011
Lopinavir exposure is insufficient in children given double doses of lopinavir/ritonavir during rifampicin-based treatment for tuberculosis.
    Antiviral therapy, 2011, Volume: 16, Issue:3

    Topics: Anti-HIV Agents; Antitubercular Agents; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Female; HIV; HIV Infections; Humans; Infant; Lopinavir; Male; Pyrimidinones; Rifampin; Ritonavir; South Africa; Treatment Outcome; Tuberculosis

2011
Rhabdomyolysis in an HIV-infected patient with impaired renal function concomitantly treated with rosuvastatin and lopinavir/ritonavir.
    Antiviral therapy, 2011, Volume: 16, Issue:3

    Topics: Anti-HIV Agents; Drug Therapy, Combination; Dyslipidemias; Fluorobenzenes; HIV Infections; HIV-1; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lopinavir; Male; Middle Aged; Pyrimidines; Pyrimidinones; Renal Insufficiency; Rhabdomyolysis; Ritonavir; Rosuvastatin Calcium; Sulfonamides; Treatment Outcome

2011
Sex hormones, insulin resistance, and diabetes mellitus among men with or at risk for HIV infection.
    Journal of acquired immune deficiency syndromes (1999), 2011, Oct-01, Volume: 58, Issue:2

    Topics: Adult; Blood Glucose; Cross-Sectional Studies; Diabetes Mellitus; Fasting; HIV Infections; HIV Protease Inhibitors; Humans; Insulin Resistance; Logistic Models; Lopinavir; Male; Middle Aged; Odds Ratio; Reverse Transcriptase Inhibitors; Ritonavir; Sex Hormone-Binding Globulin; Stavudine; Testosterone

2011
Ritonavir-boosted atazanavir exposure is associated with an increased rate of renal stones compared with efavirenz, ritonavir-boosted lopinavir and ritonavir-boosted darunavir.
    AIDS (London, England), 2011, Aug-24, Volume: 25, Issue:13

    Topics: Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Bilirubin; Cohort Studies; Cyclopropanes; Darunavir; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Nephrolithiasis; Oligopeptides; Pyridines; Pyrimidinones; Retrospective Studies; Ritonavir; Sulfonamides

2011
Efficacy of lopinavir-ritonavir reduced dose in HIV-infected patients.
    AIDS patient care and STDs, 2011, Volume: 25, Issue:8

    Topics: Adult; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Pyrimidinones; Ritonavir; Viral Load

2011
Association of prenatal and postnatal exposure to lopinavir-ritonavir and adrenal dysfunction among uninfected infants of HIV-infected mothers.
    JAMA, 2011, Jul-06, Volume: 306, Issue:1

    Topics: 17-alpha-Hydroxyprogesterone; Adrenal Insufficiency; Case-Control Studies; Cross-Sectional Studies; Dehydroepiandrosterone Sulfate; Female; France; HIV Infections; HIV-1; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Lopinavir; Male; Pregnancy; Pregnancy Complications, Infectious; Pyrimidinones; Retrospective Studies; Ritonavir; Zidovudine

2011
An application of collaborative targeted maximum likelihood estimation in causal inference and genomics.
    The international journal of biostatistics, 2010, Volume: 6, Issue:1

    Topics: Causality; Drug Resistance, Viral; Female; Genomics; HIV Infections; Humans; Likelihood Functions; Lopinavir; Male; Models, Statistical; Probability; Propensity Score

2010
Antiretroviral therapy responses among children attending a large public clinic in Soweto, South Africa.
    The Pediatric infectious disease journal, 2011, Volume: 30, Issue:11

    Topics: Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; Child; Child, Preschool; Cohort Studies; Coinfection; Cyclopropanes; Female; Follow-Up Studies; HIV; HIV Infections; Hospitals, Public; Humans; Infant; Lopinavir; Male; Mycobacterium tuberculosis; Recurrence; Ritonavir; South Africa; Survival Analysis; Tuberculosis, Pulmonary; Viral Load

2011
CYP3A5, ABCB1, and SLCO1B1 polymorphisms and pharmacokinetics and virologic outcome of lopinavir/ritonavir in HIV-infected children.
    Therapeutic drug monitoring, 2011, Volume: 33, Issue:4

    Topics: Adolescent; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Child; Child, Preschool; Cohort Studies; Cytochrome P-450 CYP3A; Female; Gene Frequency; Genotype; HIV Infections; HIV Protease Inhibitors; Humans; Liver-Specific Organic Anion Transporter 1; Lopinavir; Male; Organic Anion Transporters; Polymorphism, Genetic; Prospective Studies; Ritonavir

2011
Lopinavir/ritonavir resistance in patients infected with HIV-1: two divergent resistance pathways?
    Journal of medical virology, 2011, Volume: 83, Issue:10

    Topics: Adult; Drug Resistance, Viral; Female; Genotype; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Mutation; Retrospective Studies; Ritonavir; RNA, Viral

2011
Antiretroviral therapy alone resulted in successful resolution of large idiopathic esophageal ulcers in a patient with acute retroviral syndrome.
    AIDS (London, England), 2011, Aug-24, Volume: 25, Issue:13

    Topics: Adenine; Adult; Anti-HIV Agents; Antiviral Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Esophageal Diseases; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Organophosphonates; Pyrimidinones; Ritonavir; RNA, Viral; Syndrome; Tenofovir; Ulcer

2011
The lopinavir/ritonavir-associated rise in lipids is not related to lopinavir or ritonavir plasma concentration.
    Antiviral therapy, 2011, Volume: 16, Issue:5

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Databases, Factual; Drug Combinations; Drug Monitoring; Drug Synergism; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lipids; Lipoproteins, HDL; Lipoproteins, LDL; Lopinavir; Male; Middle Aged; Netherlands; Ritonavir

2011
Exposure to HIV-protease inhibitors selects for increased expression of P-glycoprotein (ABCB1) in Kaposi's sarcoma cells.
    British journal of cancer, 2011, Aug-09, Volume: 105, Issue:4

    Topics: Antibiotics, Antineoplastic; Atazanavir Sulfate; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lopinavir; Nelfinavir; Oligopeptides; Pyridines; Pyrimidinones; Reverse Transcriptase Polymerase Chain Reaction; Ritonavir; Sarcoma, Kaposi; Treatment Outcome

2011
Optimizing antiretroviral product selection: a sample approach to improving patient outcomes, saving money, and scaling-up health services in developing countries.
    Journal of acquired immune deficiency syndromes (1999), 2011, Volume: 57 Suppl 2

    Topics: Anti-Retroviral Agents; Atazanavir Sulfate; Developing Countries; Didanosine; Dideoxynucleosides; Drug Therapy, Combination; Health Planning; Health Services; HIV Infections; Humans; Lamivudine; Lopinavir; Oligopeptides; Pyridines; Pyrimidinones; Treatment Outcome

2011
Population pharmacokinetics of lopinavir/ritonavir (Kaletra) in HIV-infected patients.
    Therapeutic drug monitoring, 2011, Volume: 33, Issue:5

    Topics: Adult; Anti-HIV Agents; Drug Combinations; Drug Monitoring; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Models, Biological; Reproducibility of Results; Ritonavir

2011
Simplified human immunodeficiency virus maintenance therapy in virologically suppressed children with Ritonavir-boosted protease inhibitor monotherapy.
    The Pediatric infectious disease journal, 2011, Volume: 30, Issue:10

    Topics: Adolescent; Anti-HIV Agents; Atazanavir Sulfate; Child; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Oligopeptides; Pyridines; Ritonavir; RNA, Viral; Treatment Outcome; Viral Load

2011
Polymorphism in Gag gene cleavage sites of HIV-1 non-B subtype and virological outcome of a first-line lopinavir/ritonavir single drug regimen.
    PloS one, 2011, Volume: 6, Issue:9

    Topics: gag Gene Products, Human Immunodeficiency Virus; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Mutation; Polymorphism, Genetic; Ritonavir; Treatment Outcome

2011
Sustained virological response to a raltegravir-containing salvage therapy in an HIV-2-infected patient.
    AIDS (London, England), 2011, Nov-28, Volume: 25, Issue:18

    Topics: Adenine; Anti-HIV Agents; Antiviral Agents; CD4 Lymphocyte Count; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV Protease Inhibitors; HIV-2; Humans; Lopinavir; Male; Middle Aged; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Ritonavir; Salvage Therapy; Tenofovir; Treatment Outcome; Viral Load

2011
Different baseline characteristics and different outcomes of HIV-infected patients receiving HAART through clinical trials compared with routine care in Mexico.
    Journal of acquired immune deficiency syndromes (1999), 2012, Feb-01, Volume: 59, Issue:2

    Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; CD4 Lymphocyte Count; Clinical Trials as Topic; Deoxycytidine; Emtricitabine; Epidemiologic Methods; Female; HIV Infections; Humans; Kaplan-Meier Estimate; Lopinavir; Male; Mexico; Nevirapine; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; Tenofovir

2012
Can linear regression modeling help clinicians in the interpretation of genotypic resistance data? An application to derive a lopinavir-score.
    PloS one, 2011, Volume: 6, Issue:11

    Topics: Cohort Studies; Data Interpretation, Statistical; Drug Resistance, Viral; Genotype; Health Personnel; HIV; HIV Infections; Humans; Internet; Linear Models; Lopinavir; Mutation

2011
Model-based approach to dose optimization of lopinavir/ritonavir when co-administered with rifampicin.
    British journal of clinical pharmacology, 2012, Volume: 73, Issue:5

    Topics: Adult; Anti-HIV Agents; Antibiotics, Antitubercular; Biological Availability; Cohort Studies; Dose-Response Relationship, Drug; Drug Dosage Calculations; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Rifampin; Ritonavir

2012
Economics of switching to second-line antiretroviral therapy with lopinavir/ritonavir in Africa: estimates based on DART trial results and costs for Uganda and Kenya.
    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 2011, Volume: 14, Issue:8

    Topics: Anti-HIV Agents; CD4-Positive T-Lymphocytes; Cost-Benefit Analysis; Decision Support Techniques; Drug Combinations; Drug Costs; Health Care Costs; HIV Infections; Humans; Kenya; Lopinavir; Markov Chains; Models, Economic; Quality of Life; Quality-Adjusted Life Years; Ritonavir; Uganda

2011
Ribavirin and interferon alter MMP-9 abundance in vitro and in HIV-HCV-coinfected patients.
    Antiviral therapy, 2011, Volume: 16, Issue:8

    Topics: Adult; Antiviral Agents; Cell Line; Cohort Studies; Coinfection; Female; Hepacivirus; Hepatic Stellate Cells; Hepatitis C, Chronic; HIV; HIV Infections; Humans; Interferon alpha-2; Interferon-alpha; Ireland; Lopinavir; Male; Monocytes; Recombinant Proteins; Ribavirin; RNA, Viral; Saquinavir; Tissue Inhibitor of Metalloproteinase-2; United Kingdom; Viral Load

2011
Lopinavir/ritonavir single agent therapy as a universal combination antiretroviral therapy stopping strategy: results from the STOP 1 and STOP 2 studies.
    The Journal of antimicrobial chemotherapy, 2012, Volume: 67, Issue:3

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; HIV; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Plasma; Ritonavir; Time Factors; Treatment Outcome; Viral Load

2012
Recent HIV-1 infection: to treat or not to treat, that is the question.
    The Journal of infectious diseases, 2012, Jan-01, Volume: 205, Issue:1

    Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Combinations; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Organophosphonates; Ritonavir; Tenofovir; Viral Load

2012
Association of nephrotic syndrome with immune reconstitution inflammatory syndrome.
    Pediatric nephrology (Berlin, Germany), 2012, Volume: 27, Issue:4

    Topics: Anti-Retroviral Agents; Brain Diseases; Drug Combinations; HIV Infections; HIV-1; Humans; Immune Reconstitution Inflammatory Syndrome; Infant; Lopinavir; Nephrotic Syndrome; Pneumonia, Pneumocystis; Ritonavir

2012
Frequency and patterns of protease gene resistance mutations in HIV-infected patients treated with lopinavir/ritonavir as their first protease inhibitor.
    The Journal of antimicrobial chemotherapy, 2012, Volume: 67, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Cohort Studies; Drug Resistance, Viral; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Molecular Sequence Data; Mutation, Missense; Ritonavir; RNA, Viral; Selection, Genetic; Sequence Analysis, DNA; Treatment Failure; United Kingdom; Young Adult

2012
Lopinavir/ritonavir trough concentrations with the tablet formulation in HIV-1-infected women during the third trimester of pregnancy.
    Scandinavian journal of infectious diseases, 2012, Volume: 44, Issue:5

    Topics: Adult; Anti-HIV Agents; Drug Combinations; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, Third; Reverse Transcriptase Inhibitors; Ritonavir; Tablets; Treatment Outcome; Young Adult; Zidovudine

2012
Population pharmacokinetics of lopinavir and ritonavir in combination with rifampicin-based antitubercular treatment in HIV-infected children.
    Antiviral therapy, 2012, Volume: 17, Issue:1

    Topics: Antitubercular Agents; Antiviral Agents; Child, Preschool; Coinfection; Drug Administration Schedule; Drug Dosage Calculations; Drug Therapy, Combination; Female; HIV Infections; Humans; Infant; Lopinavir; Male; Models, Statistical; Mycobacterium tuberculosis; Rifampin; Ritonavir; Tuberculosis, Pulmonary

2012
Low dose lopinavir/ritonavir tablet achieves adequate pharmacokinetic parameters in HIV-infected Thai adolescents.
    Antiviral therapy, 2012, Volume: 17, Issue:2

    Topics: Adolescent; Antiretroviral Therapy, Highly Active; Child; Cross-Over Studies; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Prospective Studies; Ritonavir; Thailand

2012
Osteoporotic fracture risk associated with cumulative exposure to tenofovir and other antiretroviral agents.
    AIDS (London, England), 2012, Apr-24, Volume: 26, Issue:7

    Topics: Adenine; Adolescent; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; Hip Fractures; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Organophosphonates; Osteoporotic Fractures; Retrospective Studies; Risk; Risk Factors; Ritonavir; Spinal Fractures; Tenofovir; Time Factors; Treatment Outcome; Wrist Injuries; Young Adult

2012
Incurred sample reanalysis comparison of dried blood spots and plasma samples on the measurement of lopinavir in clinical samples.
    Bioanalysis, 2012, Volume: 4, Issue:3

    Topics: Anti-HIV Agents; Dried Blood Spot Testing; HIV Infections; Humans; Lopinavir; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2012
The role of polymorphisms at position 89 in the HIV-1 protease gene in the development of drug resistance to HIV-1 protease inhibitors.
    The Journal of antimicrobial chemotherapy, 2012, Volume: 67, Issue:4

    Topics: Amino Acid Substitution; Anti-HIV Agents; Atazanavir Sulfate; Cells, Cultured; Drug Resistance, Viral; Genotype; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Leukocytes, Mononuclear; Lopinavir; Nelfinavir; Oligopeptides; Polymorphism, Genetic; Pyridines; Virus Cultivation

2012
Virologic failures on initial boosted-PI regimen infrequently possess low-level variants with major PI resistance mutations by ultra-deep sequencing.
    PloS one, 2012, Volume: 7, Issue:2

    Topics: Anti-HIV Agents; Atazanavir Sulfate; Drug Resistance, Viral; Genotype; High-Throughput Nucleotide Sequencing; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Mutation; Oligopeptides; Pyridines; Ritonavir; Viral Load

2012
Renal function in patients with HIV starting therapy with tenofovir and either efavirenz, lopinavir or atazanavir.
    AIDS (London, England), 2012, Mar-13, Volume: 26, Issue:5

    Topics: Adenine; Adult; Alkynes; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Drug Therapy, Combination; Female; Glomerular Filtration Rate; HIV Infections; HIV Protease Inhibitors; Humans; Kidney; Lopinavir; Male; Middle Aged; Oligopeptides; Organophosphonates; Pyridines; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Treatment Outcome

2012
Human immunodeficiency virus protease inhibitors modulate Ca2+ homeostasis and potentiate alcoholic stress and injury in mice and primary mouse and human hepatocytes.
    Hepatology (Baltimore, Md.), 2012, Volume: 56, Issue:2

    Topics: Animals; Calcium; Calcium Signaling; Cell Death; Central Nervous System Depressants; DNA-Binding Proteins; Endoplasmic Reticulum Stress; Ethanol; Hepatocytes; HIV Infections; HIV Protease Inhibitors; Homeostasis; Humans; Liver Diseases, Alcoholic; Lopinavir; Male; Mice; Mice, Inbred C57BL; Primary Cell Culture; Regulatory Factor X Transcription Factors; Ritonavir; RNA, Messenger; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sterol Regulatory Element Binding Protein 1; Transcription Factors

2012
The safety, effectiveness and concentrations of adjusted lopinavir/ritonavir in HIV-infected adults on rifampicin-based antitubercular therapy.
    PloS one, 2012, Volume: 7, Issue:3

    Topics: Adult; Anti-HIV Agents; Antitubercular Agents; Coinfection; Drug Interactions; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Rifampin; Ritonavir; Tuberculosis

2012
Trough lopinavir concentrations in preterm HIV-infected infants.
    The Pediatric infectious disease journal, 2012, Volume: 31, Issue:6

    Topics: Anti-HIV Agents; HIV Infections; Humans; Infant; Infant, Newborn; Lopinavir; Plasma

2012
Transplacental passage of nevirapine, nelfinavir and lopinavir.
    The Netherlands journal of medicine, 2012, Volume: 70, Issue:2

    Topics: Anti-HIV Agents; Chromatography, High Pressure Liquid; Female; Fetal Blood; HIV Infections; Humans; Lopinavir; Maternal-Fetal Exchange; Nelfinavir; Nevirapine; Pregnancy

2012
Nevirapine-based therapy after suppression: can we switch?
    The Lancet. Infectious diseases, 2012, Volume: 12, Issue:7

    Topics: Anti-HIV Agents; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Nevirapine; Ritonavir

2012
Perinatal lopinavir + ritonavir: adrenal insufficiency.
    Prescrire international, 2012, Volume: 21, Issue:125

    Topics: Adrenal Insufficiency; Adult; Anti-HIV Agents; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; Humans; Infant, Newborn; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Ritonavir

2012
Mutations in the protease gene associated with virological failure to lopinavir/ritonavir-containing regimens.
    The Journal of antimicrobial chemotherapy, 2012, Volume: 67, Issue:6

    Topics: Adult; Amino Acid Substitution; Anti-HIV Agents; Cohort Studies; Female; HIV; HIV Infections; HIV Protease; Humans; Lopinavir; Male; Mutation, Missense; Retrospective Studies; Ritonavir; Treatment Failure; United States

2012
Simultaneous determination of lamivudine, lopinavir, ritonavir, and zidovudine concentration in plasma of HIV-infected patients by HPLC-MS/MS.
    IUBMB life, 2012, Volume: 64, Issue:5

    Topics: Anti-HIV Agents; Calibration; Chromatography, High Pressure Liquid; HIV Infections; Humans; Lamivudine; Limit of Detection; Lopinavir; Reference Standards; Reproducibility of Results; Ritonavir; Tandem Mass Spectrometry; Zidovudine

2012
Estimation of the effect of SLCO1B1 polymorphisms on lopinavir plasma concentration in HIV-infected adults.
    Antiviral therapy, 2012, Volume: 17, Issue:5

    Topics: Adult; Aged; Anti-HIV Agents; Computer Simulation; Female; Genotype; HIV Infections; Humans; Liver-Specific Organic Anion Transporter 1; Lopinavir; Male; Middle Aged; Models, Statistical; Organic Anion Transporters; Polymorphism, Single Nucleotide; Young Adult

2012
Evaluation of myocardial infarction and coronary artery disease in subjects taking lopinavir/ritonavir: a study using clinical trial and pharmacovigilance databases.
    International journal of clinical pharmacology and therapeutics, 2012, Volume: 50, Issue:6

    Topics: Adult; Anti-HIV Agents; Clinical Trials as Topic; Coronary Artery Disease; Female; HIV Infections; Humans; Lopinavir; Male; Myocardial Infarction; Pharmacovigilance; Risk Factors; Ritonavir

2012
Simplification to monotherapy with lopinavir/ritonavir in adolescents with vertically acquired HIV-1 infection.
    Journal of chemotherapy (Florence, Italy), 2012, Volume: 24, Issue:1

    Topics: Adolescent; Adult; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Infectious Disease Transmission, Vertical; Lopinavir; Male; Ritonavir; RNA, Viral; Treatment Outcome; Viral Load; Young Adult

2012
Dynamics of the resting CD4(+) T-cell latent HIV reservoir in infants initiating HAART less than 6 months of age.
    AIDS (London, England), 2012, Jul-31, Volume: 26, Issue:12

    Topics: Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes; Disease Reservoirs; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Infant; Lopinavir; Male; Ritonavir; Treatment Outcome; Viral Load; Virus Latency; Virus Replication

2012
Simultaneous quantification of lopinavir and ritonavir in human plasma by high performance liquid chromatography coupled with UV detection.
    Science China. Life sciences, 2012, Volume: 55, Issue:4

    Topics: Calibration; Chromatography, High Pressure Liquid; Diazepam; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Reference Standards; Reproducibility of Results; Ritonavir; Spectrophotometry, Ultraviolet

2012
HIV: a growing concern in the elderly population.
    The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 2012, Volume: 27, Issue:5

    Topics: Aged; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antihypertensive Agents; Azithromycin; CD4 Lymphocyte Count; Depressive Disorder; Diltiazem; Drug Interactions; Drug Monitoring; HIV Infections; Humans; Hypertension; Lopinavir; Male; Patient Compliance; Pharmacists; Renal Insufficiency; Trimethoprim, Sulfamethoxazole Drug Combination; Zidovudine

2012
Incidence, predictors and significance of severe toxicity in patients with human immunodeficiency virus-associated Hodgkin lymphoma.
    Leukemia & lymphoma, 2012, Volume: 53, Issue:12

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Antiretroviral Therapy, Highly Active; Bleomycin; Dacarbazine; Doxorubicin; Female; Hematologic Diseases; HIV Infections; HIV Protease Inhibitors; Hodgkin Disease; Humans; Incidence; Kaplan-Meier Estimate; Lopinavir; Lung Diseases; Male; Mechlorethamine; Middle Aged; Nervous System Diseases; Prednisone; Procarbazine; Prognosis; Retrospective Studies; Ritonavir; Vinblastine; Vincristine

2012
Lopinavir pharmacokinetic profiles in HIV-infected patients during rifabutin-based anti-mycobacterial therapy.
    The Journal of antimicrobial chemotherapy, 2012, Volume: 67, Issue:10

    Topics: Adult; Anti-HIV Agents; Antitubercular Agents; Chromatography, High Pressure Liquid; Drug Interactions; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Plasma; Rifabutin; Ritonavir; Tuberculosis

2012
Severe dyslipidaemia after the addition of raltegravir to a lopinavir/ritonavir-containing regimen.
    Antiviral therapy, 2012, Volume: 17, Issue:7

    Topics: Cholesterol, HDL; Drug Interactions; Drug Therapy, Combination; Dyslipidemias; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pyrrolidinones; Raltegravir Potassium; Ritonavir; Treatment Outcome; Triglycerides

2012
Impact of lopinavir/ritonavir use on antiretroviral resistance in recent clinical practice.
    The Journal of antimicrobial chemotherapy, 2012, Volume: 67, Issue:10

    Topics: Adult; Anti-HIV Agents; Cross-Sectional Studies; Drug Resistance, Viral; Female; France; Genotype; HIV Infections; HIV-1; Humans; Lopinavir; Male; Microbial Sensitivity Tests; Middle Aged; Ritonavir; Treatment Failure; Viral Load

2012
Pharmacokinetics and 48-week safety and efficacy of generic lopinavir/ritonavir in Thai HIV-infected patients.
    Antiviral therapy, 2013, Volume: 18, Issue:2

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Combinations; Female; Follow-Up Studies; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Prospective Studies; Ritonavir; Thailand; Treatment Outcome; Viral Load

2013
Free and total plasma levels of lopinavir during pregnancy, at delivery and postpartum: implications for dosage adjustments in pregnant women.
    Antiviral therapy, 2013, Volume: 18, Issue:2

    Topics: Adult; Anti-HIV Agents; Blood Proteins; Delivery, Obstetric; Female; HIV Infections; Humans; Lopinavir; Maternal-Fetal Exchange; Middle Aged; Orosomucoid; Postpartum Period; Pregnancy; Prospective Studies; Protein Binding; Serum Albumin; Young Adult

2013
Duration of first-line antiretroviral therapy with tenofovir and emtricitabine combined with atazanavir/ritonavir, efavirenz or lopinavir/ritonavir in the Italian ARCA cohort.
    The Journal of antimicrobial chemotherapy, 2013, Volume: 68, Issue:1

    Topics: Adenine; Alkynes; Anti-Retroviral Agents; Atazanavir Sulfate; Benzoxazines; Cohort Studies; Cyclopropanes; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV-1; Humans; Italy; Longitudinal Studies; Lopinavir; Oligopeptides; Organophosphonates; Prospective Studies; Pyridines; Retrospective Studies; Ritonavir; Tenofovir; Time Factors

2013
Incidence of renal toxicity in HIV-infected, antiretroviral-naïve patients starting tenofovir/emtricitabine associated with efavirenz, atazanavir/ritonavir, or lopinavir/ritonavir.
    Scandinavian journal of infectious diseases, 2013, Volume: 45, Issue:2

    Topics: Adenine; Adult; Alkynes; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Deoxycytidine; Emtricitabine; Female; Glomerular Filtration Rate; Glycosuria; HIV Infections; HIV Protease Inhibitors; Humans; Kidney Diseases; Lopinavir; Male; Middle Aged; Oligopeptides; Organophosphonates; Proteinuria; Pyridines; Retrospective Studies; Ritonavir; Tenofovir

2013
Higher CNS penetration-effectiveness of long-term combination antiretroviral therapy is associated with better HIV-1 viral suppression in cerebrospinal fluid.
    Journal of acquired immune deficiency syndromes (1999), 2013, Jan-01, Volume: 62, Issue:1

    Topics: Adult; Alkynes; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Benzoxazines; Cerebrospinal Fluid; Cyclopropanes; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Oligopeptides; Plasma; Pyridines; RNA, Viral; Treatment Outcome; Viral Load

2013
Impact of gag genetic determinants on virological outcome to boosted lopinavir-containing regimen in HIV-2-infected patients.
    AIDS (London, England), 2013, Jan-02, Volume: 27, Issue:1

    Topics: DNA, Viral; Drug Resistance, Viral; Female; gag Gene Products, Human Immunodeficiency Virus; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-2; Humans; Lopinavir; Male; Molecular Sequence Data; Mutation; pol Gene Products, Human Immunodeficiency Virus; Protease Inhibitors; Viral Load

2013
Coadministration of lopinavir/ritonavir and rifampicin in HIV and tuberculosis co-infected adults in South Africa.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Adolescent; Adult; Anti-HIV Agents; Antibiotics, Antitubercular; Child; Coinfection; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Kaplan-Meier Estimate; Lopinavir; Male; Middle Aged; Retrospective Studies; Rifampin; Ritonavir; South Africa; Time Factors; Tuberculosis; Young Adult

2012
Secondary patenting of branded pharmaceuticals: a case study of how patents on two HIV drugs could be extended for decades.
    Health affairs (Project Hope), 2012, Volume: 31, Issue:10

    Topics: Databases, Factual; Drug Combinations; Drug Industry; Economic Competition; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Patents as Topic; Ritonavir

2012
Lopinavir dosing in HIV-infected children in the United Kingdom and Ireland.
    The Pediatric infectious disease journal, 2013, Volume: 32, Issue:1

    Topics: Anti-HIV Agents; Chi-Square Distribution; Child; Child, Preschool; Cohort Studies; Female; HIV Infections; Humans; Infant; Ireland; Lopinavir; Male; Ritonavir; United Kingdom; Viral Load

2013
The advantages of therapeutic drug monitoring in patients receiving antiretroviral treatment and experiencing medication-related problems.
    Therapeutic drug monitoring, 2013, Volume: 35, Issue:1

    Topics: Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Benzoxazines; Cohort Studies; Cyclopropanes; Drug Monitoring; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Nevirapine; Oligopeptides; Prospective Studies; Pyridines; Reverse Transcriptase Inhibitors

2013
Long-term lopinavir/ritonavir monotherapy in HIV-infected children.
    The Pediatric infectious disease journal, 2013, Volume: 32, Issue:4

    Topics: Adolescent; Anti-HIV Agents; Child; Female; HIV; HIV Infections; Humans; Lopinavir; Male; Ritonavir; Time Factors; Treatment Outcome; Viral Load

2013
ART regimen protects children from malaria.
    BMJ (Clinical research ed.), 2012, Dec-03, Volume: 345

    Topics: Child; Drug Combinations; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Malaria, Falciparum; Reverse Transcriptase Inhibitors; Ritonavir

2012
Protein binding of lopinavir and ritonavir during 4 phases of pregnancy: implications for treatment guidelines.
    Journal of acquired immune deficiency syndromes (1999), 2013, May-01, Volume: 63, Issue:1

    Topics: Adolescent; Adult; Blood Proteins; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimesters; Prospective Studies; Protein Binding; Ritonavir; Young Adult

2013
Adherence and viral suppression among infants and young children initiating protease inhibitor-based antiretroviral therapy.
    The Pediatric infectious disease journal, 2013, Volume: 32, Issue:5

    Topics: Female; HIV Infections; HIV Protease Inhibitors; Humans; Infant; Lopinavir; Male; Medication Adherence; Odds Ratio; Ritonavir; Viral Load

2013
Polymeric nanoparticles containing combination antiretroviral drugs for HIV type 1 treatment.
    AIDS research and human retroviruses, 2013, Volume: 29, Issue:5

    Topics: Alkynes; Anti-HIV Agents; Benzoxazines; CD4-Positive T-Lymphocytes; Cell Line; Cell Survival; Cyclopropanes; Drug Therapy, Combination; HeLa Cells; HIV Infections; HIV-1; Humans; Lactic Acid; Lopinavir; Microscopy, Confocal; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Subcellular Fractions; U937 Cells

2013
Second-line protease inhibitor-based HAART after failing non-nucleoside reverse transcriptase inhibitor-based regimens in Asian HIV-infected children.
    Antiviral therapy, 2013, Volume: 18, Issue:4

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Asia, Southeastern; Blood Glucose; CD4-Positive T-Lymphocytes; Child; Cohort Studies; Female; HIV Infections; HIV-1; Humans; Lipoproteins; Lopinavir; Male; Protease Inhibitors; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Viral Load

2013
Initiation of antiretroviral therapy before 6 months of age is associated with faster growth recovery in South African children perinatally infected with human immunodeficiency virus.
    The Journal of pediatrics, 2013, Volume: 162, Issue:6

    Topics: Age Factors; Anthropometry; Anti-Retroviral Agents; Drug Therapy, Combination; Female; HIV Infections; Humans; Infant; Infant, Newborn; Lamivudine; Lopinavir; Male; Ritonavir; South Africa; Stavudine; Time Factors; Treatment Outcome

2013
Ongoing HIV replication in cerebrospinal fluid under successful monotherapy.
    Antiviral therapy, 2013, Volume: 18, Issue:4

    Topics: Drug Resistance, Viral; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Mutation; Ritonavir; RNA, Viral; Sequence Analysis, RNA; Viral Load; Virus Replication

2013
[When nucleoside analogs cannot be tolerated. HIV therapy with booster].
    MMW Fortschritte der Medizin, 2002, May-09, Volume: 144, Issue:19

    Topics: Anti-HIV Agents; Drug Synergism; Drug Therapy, Combination; HIV Infections; Humans; Lopinavir; Pyrimidinones; Ritonavir; Saquinavir; Treatment Outcome; Viral Load

2002
Anti-HIV agents. Lopinavir--results after one year.
    TreatmentUpdate, 2001,Winter, Volume: 12, Issue:8

    Topics: CD4 Lymphocyte Count; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Pyrimidinones; Viral Load

2001
Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice.
    Journal of acquired immune deficiency syndromes (1999), 2002, Aug-15, Volume: 30, Issue:5

    Topics: Anti-HIV Agents; Drug Resistance, Viral; Drug Therapy, Combination; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Mutation; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Failure; Treatment Outcome

2002
Kaletra OK'd by FDA.
    Positive living (Los Angeles, Calif.), 2000, Volume: 9, Issue:9

    Topics: Drug Approval; Drug Combinations; Drug Costs; Drug Resistance, Microbial; HIV Infections; HIV Protease Inhibitors; Lopinavir; Pyrimidinones; Ritonavir; United States; United States Food and Drug Administration

2000
Kaletra (ABT-378/r) application for accelerated approval.
    AIDS treatment news, 2000, Jun-23, Issue:345

    Topics: Drug Approval; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; United States; United States Food and Drug Administration

2000
Limited penetration of lopinavir into seminal plasma of HIV-1-infected men.
    AIDS (London, England), 2002, Aug-16, Volume: 16, Issue:12

    Topics: HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Pyrimidinones; Semen

2002
Kaletra (ABT-378/r) approved.
    AIDS treatment news, 2000, Sep-22, Issue:351

    Topics: Drug Approval; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; United States; United States Food and Drug Administration

2000
Antiretroviral news from ICAAC 2000.
    The Hopkins HIV report : a bimonthly newsletter for healthcare providers, 2000, Volume: 12, Issue:5

    Topics: Adenine; Antiretroviral Therapy, Highly Active; Drug Administration Schedule; Drug Resistance; HIV Infections; Humans; Lopinavir; Organophosphonates; Organophosphorus Compounds; Pyrimidinones; Ritonavir; Tenofovir

2000
Clinical use of lopinavir/ritonavir in a salvage therapy setting: pharmacokinetics and pharmacodynamics.
    AIDS (London, England), 2002, Oct-18, Volume: 16, Issue:15

    Topics: CD4 Lymphocyte Count; Female; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Mutation; Pyrimidinones; Ritonavir; Salvage Therapy; Treatment Outcome; Viral Load

2002
Lopinavir measurement in pleural effusion in a human immunodeficiency virus type 1-infected patient with kaposi's sarcoma.
    Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:11

    Topics: HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pleural Effusion; Pyrimidinones; Sarcoma, Kaposi

2002
Genotypic and phenotypic cross-resistance patterns to lopinavir and amprenavir in protease inhibitor-experienced patients with HIV viremia.
    AIDS research and human retroviruses, 2002, Sep-20, Volume: 18, Issue:14

    Topics: Carbamates; Cross-Sectional Studies; Drug Resistance, Viral; Furans; Genotype; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Microbial Sensitivity Tests; Mutation; Phenotype; Pyrimidinones; Retrospective Studies; RNA, Viral; Sulfonamides; Viremia

2002
Remission of HIV-associated myelopathy after initiation of lopinavir in a patient with extensive previous exposure to highly active antiretroviral therapy.
    AIDS (London, England), 2002, Nov-22, Volume: 16, Issue:17

    Topics: Adult; Antiretroviral Therapy, Highly Active; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Pyrimidinones; Spinal Cord Diseases

2002
Lopinavir/ritonavir absorption in a gastrectomized patient.
    AIDS (London, England), 2003, Jan-03, Volume: 17, Issue:1

    Topics: Adult; Drug Combinations; Female; Gastrectomy; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir

2003
Fresh data on new anti-HIV drugs presented in Durban.
    Positive living (Los Angeles, Calif.), 2000, Volume: 9, Issue:7

    Topics: Anti-HIV Agents; Enfuvirtide; HIV Envelope Protein gp41; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Peptide Fragments; Pyrimidinones; South Africa

2000
Immunovirological outcomes in 70 HIV-1-infected patients who switched to lopinavir/ritonavir after failing at least one protease inhibitor-containing regimen: a retrospective cohort study.
    The Journal of antimicrobial chemotherapy, 2003, Volume: 51, Issue:1

    Topics: Adult; Aged; Antiretroviral Therapy, Highly Active; Cohort Studies; Female; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Multivariate Analysis; Pyrimidinones; Retrospective Studies; Ritonavir; Treatment Outcome

2003
Small dense LDL and atherogenic lipid profile in HIV-positive adults: influence of lopinavir/ritonavir-containing regimen.
    AIDS (London, England), 2003, Mar-28, Volume: 17, Issue:5

    Topics: Adult; Antiretroviral Therapy, Highly Active; Arteriosclerosis; HIV Infections; HIV Protease Inhibitors; Humans; Hyperlipidemias; Lipids; Lipoproteins, LDL; Lopinavir; Pyrimidinones; Ritonavir

2003
Phase II clinical trials of Kaletra.
    AIDS (London, England), 2003, Apr-11, Volume: 17, Issue:6

    Topics: Clinical Trials, Phase II as Topic; Drug Combinations; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir

2003
Brief report: efficacy and treatment-limiting toxicity with the concurrent use of lopinavir/ritonavir and a third protease inhibitor in treatment-experienced HIV-infected patients.
    Journal of acquired immune deficiency syndromes (1999), 2003, Apr-15, Volume: 32, Issue:5

    Topics: Adult; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Pyrimidinones; Retrospective Studies; Ritonavir; RNA, Viral; Treatment Outcome

2003
[Kaletra (lopinavir/ritonavir--a new HIV protease inhibitor].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2002, Volume: 47, Issue:11

    Topics: HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir

2002
Improving lopinavir genotype algorithm through phenotype correlations: novel mutation patterns and amprenavir cross-resistance.
    AIDS (London, England), 2003, May-02, Volume: 17, Issue:7

    Topics: Algorithms; Carbamates; Drug Resistance, Viral; Furans; Genotype; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Mutation; Phenotype; Pyrimidinones; Sulfonamides

2003
Genotype-phenotype discordance: the evolution in our understanding HIV-1 drug resistance.
    AIDS (London, England), 2003, May-02, Volume: 17, Issue:7

    Topics: Anti-HIV Agents; Carbamates; Drug Resistance, Viral; Furans; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Phenotype; Pyrimidinones; Sulfonamides

2003
Intra-individual variability in lopinavir plasma trough concentrations supports therapeutic drug monitoring.
    AIDS (London, England), 2003, May-02, Volume: 17, Issue:7

    Topics: Adult; Anti-HIV Agents; Drug Monitoring; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones

2003
Decrease in LDL size in HIV-positive adults before and after lopinavir/ritonavir-containing regimen: an index of atherogenicity?
    Atherosclerosis, 2003, Volume: 168, Issue:1

    Topics: Adult; Antiretroviral Therapy, Highly Active; Apolipoprotein A-I; Apolipoprotein C-III; Apolipoproteins B; Apolipoproteins C; Biomarkers; Cholesterol, HDL; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lipoproteins, LDL; Lipoproteins, VLDL; Lopinavir; Male; Phospholipids; Pyrimidinones; Ritonavir; Statistics as Topic; Time Factors; Treatment Outcome; Triglycerides; Viral Load

2003
'Buffalo-hump' dermatitis: a hat trick of antiretroviral side-effects.
    Contact dermatitis, 2003, Volume: 48, Issue:3

    Topics: Anti-HIV Agents; Dermatitis, Irritant; Diagnosis, Differential; Drug Eruptions; HIV Infections; Humans; Lipodystrophy; Lopinavir; Male; Middle Aged; Nevirapine; Pyrimidinones

2003
Drug-induced rhabdomyolysis after concomitant use of clarithromycin, atorvastatin, and lopinavir/ritonavir in a patient with HIV.
    AIDS patient care and STDs, 2003, Volume: 17, Issue:5

    Topics: Adult; Anti-Bacterial Agents; Atorvastatin; Clarithromycin; Drug Interactions; Drug Therapy, Combination; Heptanoic Acids; HIV Infections; HIV Protease Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lopinavir; Male; Pyrimidinones; Pyrroles; Rhabdomyolysis; Ritonavir

2003
Factors associated with accelerated atherosclerosis in HIV-1-infected persons treated with protease inhibitors.
    AIDS patient care and STDs, 2003, Volume: 17, Issue:5

    Topics: Adult; Arteriosclerosis; Biomarkers; Black People; C-Reactive Protein; Calcium; Cholesterol; Coronary Artery Disease; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lopinavir; Male; Nelfinavir; Pyrimidinones; Ritonavir; Saquinavir

2003
Lopinavir/ritonavir plus saquinavir in salvage therapy; pharmacokinetics, tolerability and efficacy.
    AIDS (London, England), 2003, Jul-25, Volume: 17, Issue:11

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Area Under Curve; Drug Monitoring; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; Salvage Therapy; Saquinavir

2003
Detection of intrapulmonary concentration of lopinavir in an HIV-infected patient.
    AIDS (London, England), 2003, Jul-25, Volume: 17, Issue:11

    Topics: Antiretroviral Therapy, Highly Active; Bronchoalveolar Lavage Fluid; Epithelial Cells; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Lung; Male; Pyrimidinones

2003
Lack of methadone dose alterations or withdrawal symptoms during therapy with lopinavir/ritonavir.
    Journal of acquired immune deficiency syndromes (1999), 2003, Aug-15, Volume: 33, Issue:5

    Topics: Drug Interactions; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Methadone; Middle Aged; Narcotics; Pyrimidinones; Ritonavir

2003
The protease inhibitor lopinavir-ritonavir may produce opiate withdrawal in methadone-maintained patients.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2003, Aug-15, Volume: 37, Issue:4

    Topics: HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Methadone; Narcotics; Opioid-Related Disorders; Pyrimidinones; Ritonavir; Substance Withdrawal Syndrome

2003
pol gene sequence variation in Swedish HIV-2 patients failing antiretroviral therapy.
    AIDS research and human retroviruses, 2003, Volume: 19, Issue:7

    Topics: Adolescent; Adult; Africa, Western; Amino Acid Sequence; Amino Acid Substitution; Anti-HIV Agents; Codon; Drug Resistance, Multiple, Viral; Evolution, Molecular; Female; Genes, pol; Genetic Variation; HIV Infections; HIV Protease Inhibitors; HIV-1; HIV-2; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Molecular Sequence Data; Mutation, Missense; Nelfinavir; Prospective Studies; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Sequence Alignment; Sequence Homology, Amino Acid; Sweden; Treatment Failure; Viremia; Zidovudine

2003
[Lopinavir/r in new packaging].
    Deutsche medizinische Wochenschrift (1946), 2003, Aug-01, Volume: 128, Issue:31-32

    Topics: Anti-HIV Agents; Capsules; Delayed-Action Preparations; Drug Administration Schedule; Drug Packaging; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones

2003
Enhanced prediction of lopinavir resistance from genotype by use of artificial neural networks.
    The Journal of infectious diseases, 2003, Sep-01, Volume: 188, Issue:5

    Topics: Drug Resistance, Viral; Genotype; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Microbial Sensitivity Tests; Mutation; Neural Networks, Computer; Phenotype; Predictive Value of Tests; Pyrimidinones

2003
Effect of coadministered lopinavir and ritonavir (Kaletra) on tacrolimus blood concentration in liver transplantation patients.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2003, Volume: 9, Issue:9

    Topics: Adult; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Immunosuppressive Agents; Liver Diseases; Liver Transplantation; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; Tacrolimus

2003
Increased bleeding in HIV-positive haemophiliac patients treated with lopinavir-ritonavir.
    AIDS (London, England), 2003, Nov-07, Volume: 17, Issue:16

    Topics: Adolescent; Adult; Drug Combinations; Female; Hemophilia A; Hemorrhage; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Pyrimidinones; Retrospective Studies; Ritonavir

2003
Correlation between lopinavir plasma levels and lipid abnormalities in patients taking lopinavir/ritonavir.
    AIDS patient care and STDs, 2003, Volume: 17, Issue:9

    Topics: Adult; Cholesterol; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Hypercholesterolemia; Lopinavir; Male; Pyrimidinones; Ritonavir; Triglycerides

2003
Treating advanced HIV infection.
    Journal of acquired immune deficiency syndromes (1999), 2003, Nov-01, Volume: 34, Issue:3

    Topics: Alkynes; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lopinavir; Male; Oxazines; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Viral Load

2003
More data released on 908.
    AIDS patient care and STDs, 2003, Volume: 17, Issue:10

    Topics: Clinical Trials, Phase III as Topic; Drugs, Investigational; HIV Infections; Humans; Lopinavir; Protease Inhibitors; Pyrimidinones; Ritonavir; Viral Load

2003
Avascular necrosis of the femoral head in a HIV-1 infected patient receiving lopinavir/ritonavir.
    International journal of antimicrobial agents, 2003, Volume: 22, Issue:6

    Topics: Adult; Antiretroviral Therapy, Highly Active; Femur Head Necrosis; HIV Infections; HIV-1; Humans; Lopinavir; Male; Pyrimidinones; Ritonavir

2003
Kaletra goes it alone.
    GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies, 2003, Volume: 17, Issue:9

    Topics: CD4 Lymphocyte Count; Drug Combinations; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir; Viral Load

2003
No influence of the P-glycoprotein genotype (MDR1 C3435T) on plasma levels of lopinavir and efavirenz during antiretroviral treatment.
    European journal of medical research, 2003, Dec-09, Volume: 8, Issue:12

    Topics: Adult; Aged; Alkynes; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzoxazines; Cyclopropanes; Female; Genotype; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Oxazines; Polymorphism, Genetic; Pyrimidinones; Retrospective Studies

2003
Analysis of protease inhibitor combinations in vitro: activity of lopinavir, amprenavir and tipranavir against HIV type 1 wild-type and drug-resistant isolates.
    The Journal of antimicrobial chemotherapy, 2004, Volume: 53, Issue:3

    Topics: Carbamates; Drug Resistance, Viral; Enzyme-Linked Immunosorbent Assay; Furans; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pyridines; Pyrimidinones; Pyrones; RNA, Viral; Sulfonamides

2004
[Enduringly effective and tolerable initial therapy of HIV. Even after 5 years no resistance].
    MMW Fortschritte der Medizin, 2003, Dec-11, Volume: 145, Issue:50

    Topics: Anti-HIV Agents; Drug Resistance, Viral; Drug Therapy, Combination; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Nelfinavir; Pyrimidinones; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Time Factors; Viral Load

2003
[Are all boosted protease inhibitors the same? Previously treated patients profit too from lopinavir/r].
    MMW Fortschritte der Medizin, 2003, Dec-11, Volume: 145, Issue:50

    Topics: Anti-HIV Agents; Atazanavir Sulfate; Carbamates; Clinical Trials as Topic; Drug Therapy, Combination; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Oligopeptides; Organophosphates; Pilot Projects; Pyridines; Pyrimidinones; Ritonavir; Sulfonamides; Time Factors; Viral Load

2003
Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity.
    Journal of virology, 2004, Volume: 78, Issue:6

    Topics: Binding Sites; Crystallization; Crystallography, X-Ray; Drug Resistance, Multiple, Viral; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Models, Molecular; Molecular Sequence Data; Pyrimidinones

2004
Hair loss in an HIV-1 infected woman receiving lopinavir plus ritonavir therapy as first line HAART.
    Dermatology online journal, 2003, Volume: 9, Issue:5

    Topics: Adult; Alopecia; Antiretroviral Therapy, Highly Active; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Lopinavir; Nelfinavir; Pyrimidinones; Ritonavir; Stavudine

2003
FDA notifications. UCB Pharma and FDA issue advisory letter.
    AIDS alert, 2004, Volume: 19, Issue:2

    Topics: Anticonvulsants; Drug Industry; Drug Interactions; HIV Infections; HIV Protease Inhibitors; Humans; Levetiracetam; Lopinavir; Piracetam; Pyrimidinones; United States; United States Food and Drug Administration

2004
Therapeutic drug monitoring of lopinavir/ritonavir given alone or with a non-nucleoside reverse transcriptase inhibitor.
    British journal of clinical pharmacology, 2004, Volume: 57, Issue:4

    Topics: Adolescent; Adult; Drug Evaluation; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Prospective Studies; Pyrimidinones; Retrospective Studies; Reverse Transcriptase Inhibitors; Ritonavir

2004
Lopinavir/ritonavir vs. indinavir/ritonavir in antiretroviral naive HIV-infected patients: immunovirological outcome and side effects.
    Antiviral research, 2004, Volume: 62, Issue:1

    Topics: Adult; Antiretroviral Therapy, Highly Active; Cholesterol; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lopinavir; Male; Pyrimidinones; Retrospective Studies; Ritonavir; RNA, Viral; Viremia

2004
Risk of metabolic abnormalities in patients infected with HIV receiving antiretroviral therapy that contains lopinavir-ritonavir.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2004, Apr-01, Volume: 38, Issue:7

    Topics: Adult; Antiretroviral Therapy, Highly Active; Cholesterol; Cholesterol, HDL; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Metabolic Diseases; Pyrimidinones; Risk Factors; Ritonavir; Triglycerides

2004
French investigators warn of LPV/TDF/ddI interaction.
    IAPAC monthly, 2003, Volume: 9, Issue:12

    Topics: Adenine; CD4 Lymphocyte Count; Didanosine; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Organophosphonates; Organophosphorus Compounds; Pyrimidinones; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load

2003
The longer the better? Four years of durable, initially boosted protease treatment.
    AIDS (London, England), 2004, Mar-26, Volume: 18, Issue:5

    Topics: Antiretroviral Therapy, Highly Active; Gastrointestinal Diseases; HIV Infections; HIV Protease Inhibitors; HIV-Associated Lipodystrophy Syndrome; Humans; Lopinavir; Pyrimidinones; Ritonavir; Stavudine; Time Factors; Treatment Failure

2004
Virological phenotype switches under salvage therapy with lopinavir-ritonavir in heavily pretreated HIV-1 vertically infected children.
    AIDS (London, England), 2004, Jan-23, Volume: 18, Issue:2

    Topics: Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Infant; Infectious Disease Transmission, Vertical; Leukocytes, Mononuclear; Lopinavir; Male; Phenotype; Pyrimidinones; Ritonavir; Salvage Therapy; T-Lymphocyte Subsets; Viral Load; Virus Replication

2004
Lopinavir-ritonavir (Kaletra) and lithiasis: seven cases.
    AIDS (London, England), 2004, Mar-05, Volume: 18, Issue:4

    Topics: Adult; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lithiasis; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir

2004
Saquinavir drug exposure is not impaired by the boosted double protease inhibitor combination of lopinavir/ritonavir.
    AIDS (London, England), 2004, Feb-20, Volume: 18, Issue:3

    Topics: Adult; Antiretroviral Therapy, Highly Active; Capsules; Cohort Studies; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; Saquinavir; Viral Load

2004
Resistance to amprenavir before and after treatment with lopinavir/ritonavir in highly protease inhibitor-experienced HIV patients.
    AIDS (London, England), 2004, Jan-02, Volume: 18, Issue:1

    Topics: Adult; Anti-Retroviral Agents; Carbamates; CD4 Lymphocyte Count; Drug Resistance, Viral; Drug Therapy, Combination; Female; Furans; Genotype; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Mutation; Pyrimidinones; Retrospective Studies; Ritonavir; RNA, Viral; Sulfonamides

2004
Drug-drug interaction between itraconazole and the antiretroviral drug lopinavir/ritonavir in an HIV-1-infected patient with disseminated histoplasmosis.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2004, Apr-15, Volume: 38, Issue:8

    Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Antiretroviral Therapy, Highly Active; Drug Interactions; Drug Therapy, Combination; Histoplasmosis; HIV Infections; HIV Protease Inhibitors; Humans; Itraconazole; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir

2004
Failure of lopinavir-ritonavir (Kaletra)-containing regimen in an antiretroviral-naive patient.
    AIDS (London, England), 2004, Apr-30, Volume: 18, Issue:7

    Topics: Adult; Drug Combinations; Drug Resistance, Multiple, Viral; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir; Treatment Failure

2004
Changes in Kaletra labelling.
    AIDS patient care and STDs, 2004, Volume: 18, Issue:3

    Topics: Drug Combinations; Drug Labeling; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir

2004
Prediction of virological response to lopinavir/ritonavir using the genotypic inhibitory quotient.
    AIDS research and human retroviruses, 2004, Volume: 20, Issue:3

    Topics: Adult; Drug Resistance, Viral; Female; Genotype; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Mutation; Predictive Value of Tests; Pyrimidinones; Ritonavir; RNA, Viral; Salvage Therapy; Viral Load

2004
[Lopinavir: also effective using once daily dose in therapy-naive HIV patients].
    Deutsche medizinische Wochenschrift (1946), 2004, Apr-16, Volume: 129, Issue:16

    Topics: Anti-HIV Agents; Drug Administration Schedule; Drug Resistance, Viral; HIV Infections; Humans; Lopinavir; Pyrimidinones; Viral Load

2004
IQ predicts treatment response.
    AIDS patient care and STDs, 2004, Volume: 18, Issue:4

    Topics: Drug Resistance, Multiple; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Microbial Sensitivity Tests; Predictive Value of Tests; Pyrimidinones; Ritonavir

2004
[New treatment options for HIV-infected patients].
    Deutsche medizinische Wochenschrift (1946), 2004, May-07, Volume: 129, Issue:19

    Topics: Anti-HIV Agents; Atazanavir Sulfate; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Oligopeptides; Pyridines; Pyrimidinones; Ritonavir; Time Factors

2004
Differences in rates of diarrhea in patients with human immunodeficiency virus receiving lopinavir-ritonavir or nelfinavir.
    Pharmacotherapy, 2004, Volume: 24, Issue:6

    Topics: Adult; Anti-Retroviral Agents; Antidiarrheals; Antiretroviral Therapy, Highly Active; Cohort Studies; Diarrhea; Georgia; HIV Infections; Humans; Incidence; Lopinavir; Middle Aged; Nelfinavir; Pyrimidinones; Retrospective Studies; Ritonavir; United States; United States Department of Veterans Affairs

2004
Lipid abnormalities in HIV-Infected patients and lopinavir plasma concentrations.
    Journal of acquired immune deficiency syndromes (1999), 2004, Aug-15, Volume: 36, Issue:5

    Topics: Anti-HIV Agents; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Hyperlipidemias; Lipids; Lopinavir; Prospective Studies; Pyrimidinones; Ritonavir

2004
Drug resistance mutations and newly recognized treatment-related substitutions in the HIV-1 protease gene: prevalence and associations with drug exposure and real or virtual phenotypic resistance to protease inhibitors in two clinical cohorts of antiretro
    Journal of medical virology, 2004, Volume: 74, Issue:1

    Topics: Amino Acid Substitution; Carbamates; Cohort Studies; Drug Resistance, Multiple, Viral; Furans; Genes, Viral; Genotype; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Multivariate Analysis; Mutation; Phenotype; Pyrimidinones; Regression Analysis; Sulfonamides

2004
Short communication: liver toxicity of lopinavir-containing regimens in HIV-infected patients with or without hepatitis C coinfection.
    AIDS research and human retroviruses, 2004, Volume: 20, Issue:7

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Female; Hepatitis C; HIV Infections; Humans; Incidence; Liver; Lopinavir; Male; Pyrimidinones

2004
Lopinavir/ritonavir- and indinavir-induced thrombocytopenia in a patient with HIV infection.
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2004, Volume: 8, Issue:5

    Topics: Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lopinavir; Middle Aged; Pyrimidinones; Ritonavir; Thrombocytopenia

2004
Isolated lopinavir resistance after virological rebound of a ritonavir/lopinavir-based regimen.
    AIDS (London, England), 2004, Sep-24, Volume: 18, Issue:14

    Topics: Adult; Anti-HIV Agents; Drug Resistance, Multiple, Viral; HIV Infections; Humans; Lopinavir; Male; Mutation; Pyrimidinones; Ritonavir; RNA, Viral

2004
Virological, intracellular and plasma pharmacological parameters predicting response to lopinavir/ritonavir (KALEPHAR study).
    AIDS (London, England), 2004, Jun-18, Volume: 18, Issue:9

    Topics: Adult; Antiretroviral Therapy, Highly Active; Chi-Square Distribution; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Female; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV Reverse Transcriptase; HIV-1; Humans; Intracellular Fluid; Lopinavir; Male; Middle Aged; Multivariate Analysis; Mutation; Pyrimidinones; Reverse Transcriptase Inhibitors; Treatment Outcome; Viral Load

2004
Lopinavir/ritonavir treatment in HIV antiretroviral-experienced patients: evaluation of risk factors for liver enzyme elevation.
    HIV medicine, 2004, Volume: 5, Issue:5

    Topics: Adult; Aged; Alanine Transaminase; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; Follow-Up Studies; gamma-Glutamyltransferase; Hepatitis B; HIV Infections; Humans; Liver; Lopinavir; Male; Middle Aged; Prospective Studies; Pyrimidinones; Risk Factors; Ritonavir; Statistics, Nonparametric

2004
[Simplified HIV therapy. Atazanavir: the first protease inhibitor with once daily administration].
    MMW Fortschritte der Medizin, 2004, Apr-26, Volume: 146 Spec No 1

    Topics: Adult; Atazanavir Sulfate; Clinical Trials as Topic; Delayed-Action Preparations; Drug Administration Schedule; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Oligopeptides; Pyridines; Pyrimidinones; Treatment Outcome

2004
[From HAART to "smart": maximizing the advantages of lopinavir/ritonavir].
    MMW Fortschritte der Medizin, 2004, Apr-26, Volume: 146 Spec No 1

    Topics: Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Clinical Trials as Topic; Delayed-Action Preparations; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Long-Term Care; Lopinavir; Pyrimidinones; Ritonavir; Viral Load

2004
[Atazanavir protects lipid metabolism. New PI with favorable metabolic profile].
    MMW Fortschritte der Medizin, 2004, Apr-26, Volume: 146 Spec No 1

    Topics: Atazanavir Sulfate; Blood Glucose; Clinical Trials, Phase III as Topic; Drug Administration Schedule; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lipids; Lopinavir; Oligopeptides; Pyridines; Pyrimidinones; Ritonavir; Viral Load

2004
[5 years' data are convincing. Lopinavir as primary therapy is effective and safe in the long term].
    MMW Fortschritte der Medizin, 2004, Apr-26, Volume: 146 Spec No 1

    Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; CD4 Lymphocyte Count; Clinical Trials as Topic; Cyclopropanes; Drug Synergism; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Long-Term Care; Lopinavir; Organophosphonates; Oxazines; Pyrimidinones; Ritonavir; Tenofovir; Viral Load

2004
Predictive factors of virologic success in HIV-1-infected children treated with lopinavir/ritonavir.
    Journal of acquired immune deficiency syndromes (1999), 2004, Oct-01, Volume: 37, Issue:2

    Topics: Child; Child, Preschool; Drug Interactions; Drug Resistance, Viral; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Prospective Studies; Pyrimidinones; Ritonavir

2004
Simplification of therapeutic drug monitoring for twice-daily regimens of lopinavir/ritonavir for HIV infection.
    Therapeutic drug monitoring, 2004, Volume: 26, Issue:5

    Topics: Adult; Area Under Curve; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir

2004
Predictive value of HIV-1 protease genotype and virtual phenotype on the virological response to lopinavir/ritonavir-containing salvage regimens.
    Antiviral therapy, 2004, Volume: 9, Issue:4

    Topics: Adult; Canada; Cohort Studies; Female; Genotype; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Logistic Models; Lopinavir; Male; Multivariate Analysis; Mutation; Phenotype; Predictive Value of Tests; Pyrimidinones; Ritonavir; Salvage Therapy

2004
Effects of valproic acid coadministration on plasma efavirenz and lopinavir concentrations in human immunodeficiency virus-infected adults.
    Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:11

    Topics: Adult; Alkynes; Anti-HIV Agents; Anticonvulsants; Area Under Curve; Benzoxazines; Cognition Disorders; Cyclopropanes; Drug Interactions; Female; Half-Life; HIV Infections; Humans; Lopinavir; Male; Oxazines; Pyrimidinones; Reverse Transcriptase Inhibitors; Valproic Acid

2004
The plasma and intracellular steady-state pharmacokinetics of lopinavir/ritonavir in HIV-1-infected patients.
    Antiviral therapy, 2004, Volume: 9, Issue:5

    Topics: Adult; Anti-HIV Agents; Cohort Studies; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Leukocytes, Mononuclear; Lopinavir; Male; Pyrimidinones; Ritonavir

2004
Hepatotoxicity associated with protease inhibitor-based antiretroviral regimens with or without concurrent ritonavir.
    AIDS (London, England), 2004, Nov-19, Volume: 18, Issue:17

    Topics: Adult; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; Chronic Disease; Drug Therapy, Combination; Female; Hepatitis; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Liver; Lopinavir; Male; Nelfinavir; Prospective Studies; Pyrimidinones; Reverse Transcriptase Inhibitors; Risk Factors; Ritonavir; Saquinavir; Treatment Outcome

2004
First-line efavirenz versus lopinavir-ritonavir-based highly active antiretroviral therapy for naive patients.
    AIDS (London, England), 2004, Nov-19, Volume: 18, Issue:17

    Topics: Adult; Aged; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Oxazines; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Outcome; Viral Load

2004
Kaletra monotherapy controversy: AmfAR publishes overview.
    AIDS treatment news, 2004, Sep-24, Issue:405

    Topics: HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones

2004
Acquired macroglossia due to lopinavir/ritonavir treatment.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2005, Volume: 34, Issue:1

    Topics: Aged; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Macroglossia; Pyrimidinones; Ritonavir

2005
Antiretroviral drug pharmacokinetics in hepatitis with hepatic dysfunction.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2005, Jan-01, Volume: 40, Issue:1

    Topics: Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Dideoxynucleosides; Drug Therapy, Combination; Hepatitis; HIV Infections; Humans; Indinavir; Liver Function Tests; Lopinavir; Nelfinavir; Nevirapine; Oxazines; Protease Inhibitors; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Zidovudine

2005
An enzyme immunoassay for the quantification of plasma and intracellular lopinavir in HIV-infected patients.
    Journal of immunological methods, 2004, Volume: 295, Issue:1-2

    Topics: Adult; Antibodies; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; HIV Infections; HIV Protease Inhibitors; Humans; Leukocytes, Mononuclear; Lopinavir; Male; Pyrimidinones; Sensitivity and Specificity

2004
Pharmacokinetics and hepatotoxicity of lopinavir/ritonavir in non-cirrhotic HIV and hepatitis C virus (HCV) co-infected patients.
    The Journal of antimicrobial chemotherapy, 2005, Volume: 55, Issue:2

    Topics: Adult; Aged; Female; Hepacivirus; Hepatitis C; HIV Infections; Humans; Liver; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir

2005
Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing multiple virological failures.
    AIDS (London, England), 2005, Jan-28, Volume: 19, Issue:2

    Topics: Atazanavir Sulfate; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Oligopeptides; Pyridines; Pyrimidinones; Ritonavir

2005
Top stories of 2004. Back to the future: lopinavir/ritonavir as "monotherapy".
    AIDS clinical care, 2005, Volume: 17, Issue:1

    Topics: Drug Combinations; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir; Viral Load

2005
Selection of a rare resistance profile in an HIV-1-infected patient exhibiting a failure to an antiretroviral regimen including tenofovir DF.
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2005, Volume: 32, Issue:3

    Topics: Adenine; Adult; Anti-HIV Agents; Didanosine; Dideoxynucleosides; Drug Resistance, Viral; Female; Gabon; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Lopinavir; Microbial Sensitivity Tests; Mutation; Organophosphonates; Pyrimidinones; Tenofovir; Viral Load

2005
Serum hypophosphatemia in tenofovir disoproxil fumarate recipients is multifactorial in origin, questioning the utility of its monitoring in clinical practice.
    Journal of acquired immune deficiency syndromes (1999), 2005, Mar-01, Volume: 38, Issue:3

    Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Blood Chemical Analysis; Creatinine; Fanconi Syndrome; Female; HIV Infections; Humans; Hypophosphatemia; Lopinavir; Male; Organophosphonates; Phosphates; Prospective Studies; Pyrimidinones; Reproducibility of Results; Tenofovir; Urea

2005
Interruption and discontinuation of highly active antiretroviral therapy in the multicenter AIDS cohort study.
    Journal of acquired immune deficiency syndromes (1999), 2005, Mar-01, Volume: 38, Issue:3

    Topics: Adult; Age Factors; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cohort Studies; Depression; Dideoxynucleosides; Ethnicity; HIV; HIV Infections; Humans; Logistic Models; Lopinavir; Male; Middle Aged; Pyrimidinones; Risk Factors; RNA, Viral; Treatment Refusal

2005
Lopinavir/ritonavir maintenance monotherapy after successful viral suppression with standard highly active antiretroviral therapy in HIV-1-infected patients.
    AIDS (London, England), 2005, Mar-04, Volume: 19, Issue:4

    Topics: Antiretroviral Therapy, Highly Active; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pilot Projects; Pyrimidinones; Ritonavir

2005
Lopinavir/ritonavir combination and total/HDL cholesterol ratio.
    The Journal of infection, 2005, Volume: 50, Issue:3

    Topics: Adult; Cholesterol; Cholesterol, HDL; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; Humans; Hyperlipidemias; Lopinavir; Male; Middle Aged; Pyrimidinones; Retrospective Studies; Ritonavir; Time Factors

2005
Simple and simultaneous determination of the hiv-protease inhibitors amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir plus M8 nelfinavir metabolite and the nonnucleoside reverse transcriptase inhibitors efavirenz and nevi
    Therapeutic drug monitoring, 2005, Volume: 27, Issue:2

    Topics: Alkynes; Atazanavir Sulfate; Benzoxazines; Calibration; Carbamates; Chromatography, Liquid; Cyclopropanes; Drug Stability; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lopinavir; Nelfinavir; Nevirapine; Oligopeptides; Oxazines; Pyridines; Pyrimidinones; Reproducibility of Results; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Specimen Handling; Spectrophotometry, Ultraviolet; Sulfonamides

2005
Hepatitis coinfection and LPV/RTV.
    IAPAC monthly, 2004, Volume: 10, Issue:10

    Topics: Drug Therapy, Combination; Hepatitis B; Hepatitis C; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Prospective Studies; Pyrimidinones; Ritonavir

2004
Factors associated with virological response in HIV-infected patients failing antiretroviral therapy: a prospective cohort study.
    HIV medicine, 2005, Volume: 6, Issue:2

    Topics: Adult; Antiretroviral Therapy, Highly Active; Antiviral Agents; CD4 Lymphocyte Count; Dideoxynucleosides; Drug Administration Schedule; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Prospective Studies; Pyrimidinones; Ritonavir; RNA, Viral; Treatment Failure

2005
Use of lopinavir/ritonavir in HIV-infected patients failing a first-line protease-inhibitor-containing HAART.
    The Journal of antimicrobial chemotherapy, 2005, Volume: 55, Issue:6

    Topics: Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Drug Therapy, Combination; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; RNA, Viral

2005
[Meningeal cryptococcosis as a sign of immune reconstitution syndrome].
    Enfermedades infecciosas y microbiologia clinica, 2005, Volume: 23, Issue:4

    Topics: Adult; AIDS-Related Opportunistic Infections; Amphotericin B; Anti-HIV Agents; Antifungal Agents; Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes; Fluconazole; Flucytosine; HIV Infections; Humans; Immunologic Memory; Lamivudine; Lopinavir; Male; Meningitis, Cryptococcal; Pyrimidinones; Recurrence; Ritonavir; Syndrome; T-Lymphocyte Subsets; Zidovudine

2005
Evolution of resistance mutations pattern in HIV-1-infected patients during intensification therapy with a boosted protease inhibitor.
    AIDS (London, England), 2005, May-20, Volume: 19, Issue:8

    Topics: Antiretroviral Therapy, Highly Active; Carbamates; Drug Resistance, Multiple, Viral; Follow-Up Studies; Furans; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV Reverse Transcriptase; HIV-1; Humans; Indinavir; Lopinavir; Mutation; Pyrimidinones; Ritonavir; Saquinavir; Sulfonamides; Treatment Failure; Viral Load

2005
Predictive factors of lopinavir/ritonavir discontinuation for drug-related toxicity: results from a cohort of 416 multi-experienced HIV-infected individuals.
    International journal of antimicrobial agents, 2005, Volume: 26, Issue:1

    Topics: Adult; Aged; Antiretroviral Therapy, Highly Active; Cohort Studies; Drug Administration Schedule; Female; Hepatitis C; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Odds Ratio; Prospective Studies; Pyrimidinones; Risk Factors; Ritonavir

2005
Lopinavir concentrations in cerebrospinal fluid exceed the 50% inhibitory concentration for HIV.
    AIDS (London, England), 2005, Jun-10, Volume: 19, Issue:9

    Topics: Adult; Antiretroviral Therapy, Highly Active; Chromatography, Liquid; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Mass Spectrometry; Middle Aged; Prospective Studies; Pyrimidinones

2005
Pharmacokinetics of once-daily lopinavir/ritonavir and the influence of dose modifications.
    AIDS (London, England), 2005, Jul-01, Volume: 19, Issue:10

    Topics: Dose-Response Relationship, Drug; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Pyrimidinones; Ritonavir

2005
FDA approves once-daily Kaletra.
    The AIDS reader, 2005, Volume: 15, Issue:6

    Topics: Administration, Oral; AIDS Serodiagnosis; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Approval; Early Diagnosis; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Prognosis; Pyrimidinones; Survival Rate; Treatment Outcome; United States

2005
An Italian approach to postmarketing monitoring: preliminary results from the SCOLTA (Surveillance Cohort Long-Term Toxicity Antiretrovirals) project on the safety of lopinavir/ritonavir.
    Journal of acquired immune deficiency syndromes (1999), 2005, Jul-01, Volume: 39, Issue:3

    Topics: Adult; Anti-HIV Agents; Cohort Studies; Female; HIV Infections; Humans; Italy; Lopinavir; Male; Middle Aged; Product Surveillance, Postmarketing; Pyrimidinones; Ritonavir; Safety

2005
Once-daily Kaletra approved.
    AIDS patient care and STDs, 2005, Volume: 19, Issue:7

    Topics: Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Approval; Drug Therapy, Combination; Female; Follow-Up Studies; HIV Infections; Humans; Lopinavir; Male; Prospective Studies; Pyrimidinones; Risk Assessment; Treatment Outcome; United States; United States Food and Drug Administration; Viral Load

2005
Low incidence of hepatotoxicity in a cohort of HIV patients treated with lopinavir/ritonavir.
    AIDS (London, England), 2005, Sep-02, Volume: 19, Issue:13

    Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Female; Hepatitis B, Chronic; Hepatitis C, Chronic; HIV Infections; HIV Protease Inhibitors; Humans; Incidence; Italy; Liver Diseases; Lopinavir; Male; Middle Aged; Product Surveillance, Postmarketing; Pyrimidinones; Ritonavir

2005
Higher plasma lopinavir concentrations are associated with a moderate rise in cholestasis markers in HIV-infected patients.
    The Journal of antimicrobial chemotherapy, 2005, Volume: 56, Issue:4

    Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Anti-HIV Agents; Bilirubin; Biomarkers; Cholestasis; Female; gamma-Glutamyltransferase; HIV Infections; Humans; Lopinavir; Male; Pyrimidinones; Retrospective Studies

2005
Population pharmacokinetics of lopinavir in combination with ritonavir in HIV-1-infected patients.
    British journal of clinical pharmacology, 2005, Volume: 60, Issue:4

    Topics: Adult; Anti-HIV Agents; Capsules; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Models, Chemical; Pyrimidinones; Retrospective Studies; Ritonavir

2005
Mutations at codons 54 and 82 of HIV protease predict virological response of HIV-infected children on salvage lopinavir/ritonavir therapy.
    The Journal of antimicrobial chemotherapy, 2005, Volume: 56, Issue:6

    Topics: Adolescent; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Child; Child, Preschool; Drug Resistance, Viral; Female; HIV Infections; HIV Protease; HIV-1; Humans; Infant; Lopinavir; Male; Mutation; Prognosis; Prospective Studies; Pyrimidinones; Ritonavir; Salvage Therapy; Viral Load

2005
Acute generalized exanthematous pustulosis induced by HIV postexposure prophylaxis with lopinavir-ritonavir.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2005, Nov-01, Volume: 41, Issue:9

    Topics: Acute Disease; Adult; Anti-HIV Agents; Drug Eruptions; Exanthema; HIV Infections; Humans; Lopinavir; Male; Occupational Exposure; Pyrimidinones; Ritonavir; Skin Diseases, Vesiculobullous

2005
Long-term antiretroviral efficacy and safety of lopinavir/ritonavir in HAART-experienced subjects: 4 year follow-up study.
    AIDS (London, England), 2005, Nov-04, Volume: 19, Issue:16

    Topics: Adult; Antiretroviral Therapy, Highly Active; Drug Therapy, Combination; Female; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; RNA, Viral; Treatment Outcome

2005
Potential hazard of pharmacokinetic interactions between lopinavir-ritonavir protease inhibitors and irinotecan.
    AIDS (London, England), 2005, Nov-18, Volume: 19, Issue:17

    Topics: Administration, Oral; Adult; Antineoplastic Agents, Phytogenic; Antiretroviral Therapy, Highly Active; Camptothecin; Drug Interactions; HIV Infections; HIV Protease Inhibitors; Humans; Irinotecan; Lopinavir; Male; Pyrimidinones; Ritonavir; Sarcoma, Kaposi

2005
Atazanavir/ritonavir versus lopinavir/ritonavir: equivalent or different efficacy profiles?
    AIDS (London, England), 2005, Nov-18, Volume: 19, Issue:17

    Topics: Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Oligopeptides; Pyridines; Pyrimidinones; Ritonavir; RNA, Viral; Treatment Outcome

2005
Meeting notes from the 3rd IAS Conference. Old drugs, new data.
    AIDS clinical care, 2005, Volume: 17, Issue:10

    Topics: Alkynes; Anti-HIV Agents; Atenolol; Benzoxazines; Brazil; Congresses as Topic; Cyclopropanes; Deoxycytidine; Drug Therapy, Combination; HIV Infections; Humans; Lopinavir; Oxazines; Pyrimidinones; Ritonavir

2005
High rate of proV47A selection in HIV-2 patients failing lopinavir-based HAART.
    AIDS (London, England), 2006, Jan-02, Volume: 20, Issue:1

    Topics: Adolescent; Adult; Antiretroviral Therapy, Highly Active; Drug Resistance, Viral; Female; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-2; Humans; Lopinavir; Male; Middle Aged; Mutation; Phenotype; Pyrimidinones; Ritonavir; Treatment Failure

2006
Once-daily directly observed therapy lopinavir/ritonavir plus indinavir as a protease inhibitor-only salvage therapy in heavily pretreated HIV-1-infected patients: a pilot study.
    AIDS (London, England), 2006, Jan-02, Volume: 20, Issue:1

    Topics: Adult; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lopinavir; Male; Middle Aged; Patient Compliance; Pilot Projects; Pyrimidinones; Ritonavir; Treatment Outcome

2006
Antiretroviral treatment in the Northern Cape.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2005, Volume: 95, Issue:11

    Topics: Adolescent; Alkynes; Anti-Retroviral Agents; Benzoxazines; CD4 Lymphocyte Count; Child; Child, Preschool; Cyclopropanes; HIV Infections; Humans; Infant; Lamivudine; Lopinavir; Nevirapine; Oxazines; Pyrimidinones; Ritonavir; South Africa; Stavudine; Viral Load

2005
Possible interaction between lopinavir/ritonavir and valproic Acid exacerbates bipolar disorder.
    The Annals of pharmacotherapy, 2006, Volume: 40, Issue:1

    Topics: Adult; Antiretroviral Therapy, Highly Active; Bipolar Disorder; Dose-Response Relationship, Drug; Drug Interactions; Hepatitis C; HIV Infections; Humans; Lopinavir; Male; Pyrimidinones; Ritonavir; Valproic Acid

2006
[First-line monotherapy with boostered protease inhibitor. Effectively reduce viral load with only one drug?].
    MMW Fortschritte der Medizin, 2005, Apr-25, Volume: 147 Spec No 1

    Topics: CD4 Lymphocyte Count; Clinical Trials as Topic; Drug Combinations; Drug Resistance, Viral; Drug Synergism; Early Diagnosis; HIV; HIV Infections; HIV Protease Inhibitors; HIV Seropositivity; Humans; Lopinavir; Pyrimidinones; Treatment Outcome; Viral Load

2005
[HIV therapy in childhood. Also once daily lopinavir/r is effective].
    MMW Fortschritte der Medizin, 2005, Apr-25, Volume: 147 Spec No 1

    Topics: Age Factors; Anti-HIV Agents; Child; Child, Preschool; Clinical Trials as Topic; Drug Administration Schedule; HIV Infections; HIV Protease Inhibitors; Humans; Infant; Lopinavir; Pyrimidinones; Treatment Outcome; Viral Load

2005
[Highly active initial therapy without resistance development. Even after 6 years still effective HIV therapy].
    MMW Fortschritte der Medizin, 2005, Apr-25, Volume: 147 Spec No 1

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Resistance, Viral; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pyrimidinones; RNA, Viral; Viral Load

2005
[Efavirenz--comprehensive status of studies].
    MMW Fortschritte der Medizin, 2005, Apr-25, Volume: 147 Spec No 1

    Topics: Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Drug Resistance, Viral; HIV Infections; Humans; Lopinavir; Nevirapine; Oxazines; Pyrimidinones; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Treatment Outcome; Viral Load

2005
[New data on atazanavir/r]].
    MMW Fortschritte der Medizin, 2005, Apr-25, Volume: 147 Spec No 1

    Topics: Atazanavir Sulfate; Dose-Response Relationship, Drug; Drug Administration Schedule; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Oligopeptides; Pyridines; Pyrimidinones; Treatment Outcome; Viral Load

2005
[HIV infection presenting with bilateral optic neuropathy].
    Revue neurologique, 2006, Volume: 162, Issue:1

    Topics: AIDS Serodiagnosis; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Disease Progression; Drug Therapy, Combination; Evoked Potentials, Visual; Facial Nerve Diseases; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Ischemia; Lamivudine; Lopinavir; Male; Meningitis, Viral; Methylprednisolone; Middle Aged; Optic Disk; Optic Nerve Diseases; Polyradiculopathy; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Visual Fields; Zidovudine

2006
Predictive factors of hyperlipidemia in HIV-infected subjects receiving lopinavir/ritonavir.
    AIDS research and human retroviruses, 2006, Volume: 22, Issue:2

    Topics: Adult; Female; HIV Infections; HIV Protease Inhibitors; Humans; Hyperlipidemias; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir

2006
Low initial trough plasma concentrations of lopinavir are associated with an impairment of virological response in an unselected cohort of HIV-1-infected patients.
    HIV medicine, 2006, Volume: 7, Issue:3

    Topics: Adult; Chi-Square Distribution; Drug Administration Schedule; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Retrospective Studies; Ritonavir; Time Factors; Treatment Outcome; Viral Load

2006
Hyponatraemia associated with lopinavir--ritonavir?
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2007, Volume: 11, Issue:1

    Topics: Adult; Antiretroviral Therapy, Highly Active; HIV Infections; HIV Protease Inhibitors; Humans; Hyponatremia; Lopinavir; Male; Pyrimidinones; Ritonavir

2007
The genotypic inhibitory quotient and the (cumulative) number of mutations predict the response to lopinavir therapy.
    AIDS (London, England), 2006, Apr-24, Volume: 20, Issue:7

    Topics: Drug Resistance, Viral; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Mutation; Pyrimidinones; Retrospective Studies; Treatment Outcome; Virus Replication

2006
Prevalence of the HIV-1 protease mutation I47A in clinical practice and association with lopinavir resistance.
    AIDS (London, England), 2006, Apr-24, Volume: 20, Issue:7

    Topics: Carbamates; Codon; Drug Resistance, Viral; Furans; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lopinavir; Mutation; Nelfinavir; Phenotype; Pyrimidinones; Ritonavir; Saquinavir; Sulfonamides

2006
Plasma and cerebrospinal pharmacokinetics and pharmacodynamics in subjects taking lopinavir/ritonavir.
    AIDS (London, England), 2006, Apr-24, Volume: 20, Issue:7

    Topics: Adult; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Pyrimidinones; Ritonavir

2006
Limited penetration of lopinavir and ritonavir in the genital tract of men infected with HIV-1 in Brazil.
    Therapeutic drug monitoring, 2006, Volume: 28, Issue:2

    Topics: Biological Availability; Brazil; Cross-Sectional Studies; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Pyrimidinones; Regression Analysis; Ritonavir; Semen; Time Factors; Urogenital System; Viral Load

2006
Efficacy and safety of an anti-retroviral combination regimen including either efavirenz or lopinavir-ritonavir with a backbone of two nucleoside reverse transcriptase inhibitors.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2006, Volume: 12, Issue:5

    Topics: Adult; Aged; Alkynes; Benzoxazines; CD4 Lymphocyte Count; Cohort Studies; Cyclopropanes; Drug Therapy, Combination; Female; HIV; HIV Infections; HIV Protease Inhibitors; HIV-Associated Lipodystrophy Syndrome; Humans; Lopinavir; Male; Middle Aged; Oxazines; Pyrimidinones; Retrospective Studies; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Triglycerides; Viral Load

2006
Lopinavir/ritonavir as single-drug therapy for maintenance of HIV-1 viral suppression.
    Journal of acquired immune deficiency syndromes (1999), 2006, Apr-01, Volume: 41, Issue:4

    Topics: Anti-HIV Agents; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir; Viral Load

2006
Focus on hepatitis. Low rate of liver problems seen with LPV/r.
    IAPAC monthly, 2005, Volume: 11, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; HIV Infections; HIV Protease Inhibitors; Humans; Incidence; Liver; Lopinavir; Pyrimidinones; Ritonavir

2005
Atazanavir and lopinavir/ritonavir: pharmacokinetics, safety and efficacy of a promising double-boosted protease inhibitor regimen.
    AIDS (London, England), 2006, May-12, Volume: 20, Issue:8

    Topics: Adult; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Drug Combinations; Drug Monitoring; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Oligopeptides; Pilot Projects; Pyridines; Pyrimidinones; Ritonavir; Salvage Therapy; Treatment Failure; Treatment Outcome; Viral Load

2006
Dramatic interaction between levothyroxine and lopinavir/ritonavir in a HIV-infected patient.
    AIDS (London, England), 2006, May-12, Volume: 20, Issue:8

    Topics: Antiretroviral Therapy, Highly Active; Drug Interactions; Female; HIV Infections; HIV Protease Inhibitors; Humans; Hypothyroidism; Lopinavir; Middle Aged; Pyrimidinones; Ritonavir; Thyroxine

2006
Optimizing treatment for HIV-infected South African women exposed to single-dose nevirapine: balancing efficacy and cost.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2006, Jun-15, Volume: 42, Issue:12

    Topics: Adult; Anti-HIV Agents; Computer Simulation; Cost-Benefit Analysis; Decision Support Techniques; Female; HIV Infections; Humans; Lopinavir; Models, Biological; Nevirapine; Pyrimidinones; Ritonavir; South Africa

2006
Nephrotoxicity in a child with perinatal HIV on tenofovir, didanosine and lopinavir/ritonavir.
    Pediatric nephrology (Berlin, Germany), 2006, Volume: 21, Issue:7

    Topics: Adenine; Anti-HIV Agents; Child; Diabetes Insipidus, Nephrogenic; Didanosine; Drug Therapy, Combination; Fanconi Syndrome; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Kidney; Kidney Diseases; Lopinavir; Organophosphonates; Pregnancy; Pregnancy Complications; Pyrimidinones; Ritonavir; Tenofovir

2006
FDA notifications. HIV-1 adult treatment guidelines are updated.
    AIDS alert, 2006, Volume: 21, Issue:6

    Topics: Adult; Drug Combinations; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pyrimidinones; Ritonavir; United States; United States Food and Drug Administration

2006
Pharmacokinetics and tolerability of a combination of indinavir, lopinavir and ritonavir in multiply pretreated HIV-1 infected adults.
    European journal of medical research, 2006, Jun-30, Volume: 11, Issue:6

    Topics: Adult; CD4 Lymphocyte Count; Drug Administration Schedule; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lopinavir; Male; Mass Spectrometry; Maximum Tolerated Dose; Metabolic Clearance Rate; Pyrimidinones; Ritonavir; Viral Load

2006
Discovery of imidazolidine-2,4-dione-linked HIV protease inhibitors with activity against lopinavir-resistant mutant HIV.
    Bioorganic & medicinal chemistry, 2006, Oct-01, Volume: 14, Issue:19

    Topics: Crystallography, X-Ray; Drug Design; Drug Resistance, Viral; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Imidazolidines; Lopinavir; Magnetic Resonance Spectroscopy; Mutation; Pyrimidinones; Structure-Activity Relationship

2006
Genotyping of CYP2B6 and therapeutic drug monitoring in an HIV-infected patient with high efavirenz plasma concentrations and severe CNS side-effects.
    Scandinavian journal of infectious diseases, 2006, Volume: 38, Issue:8

    Topics: Adult; Alkynes; Anti-HIV Agents; Aryl Hydrocarbon Hydroxylases; Benzoxazines; Central Nervous System Diseases; Cyclopropanes; Cytochrome P-450 CYP2B6; Drug Monitoring; Genotype; HIV; HIV Infections; Humans; Lopinavir; Male; Oxazines; Oxidoreductases, N-Demethylating; Pyrimidinones

2006
Urinary beta2-microglobulin as a possible sensitive marker for renal injury caused by tenofovir disoproxil fumarate.
    AIDS research and human retroviruses, 2006, Volume: 22, Issue:8

    Topics: Adenine; Adult; Anti-HIV Agents; beta 2-Microglobulin; Biomarkers; Creatinine; Female; HIV Infections; HIV-1; Humans; Kidney Tubules; Lopinavir; Male; Middle Aged; Organophosphonates; Pyrimidinones; Tenofovir; Thinness

2006
Placental transfer and pharmacokinetics of lopinavir and other protease inhibitors in combination with nevirapine at delivery.
    AIDS (London, England), 2006, Aug-22, Volume: 20, Issue:13

    Topics: Amniotic Fluid; Antiretroviral Therapy, Highly Active; Drug Combinations; Drug Interactions; Female; Fetal Blood; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Infectious Disease Transmission, Vertical; Lopinavir; Nevirapine; Placenta; Pregnancy; Pregnancy Complications, Infectious; Prospective Studies; Pyrimidinones; Viral Load

2006
The effects of ritonavir and lopinavir/ritonavir on the pharmacokinetics of a novel CCR5 antagonist, aplaviroc, in healthy subjects.
    British journal of clinical pharmacology, 2006, Volume: 62, Issue:3

    Topics: Adolescent; Adult; Animals; Benzoates; CCR5 Receptor Antagonists; Diketopiperazines; Drug Combinations; Drug Interactions; Female; HIV Infections; Humans; Lopinavir; Male; Mice; Middle Aged; Piperazines; Pyrimidinones; Rats; Ritonavir; Spiro Compounds

2006
Regimen-dependent variations in adherence to therapy and virological suppression in patients initiating protease inhibitor-based highly active antiretroviral therapy.
    HIV medicine, 2006, Volume: 7, Issue:5

    Topics: Adult; Antiretroviral Therapy, Highly Active; British Columbia; Cohort Studies; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Nelfinavir; Patient Compliance; Pyrimidinones; Ritonavir; Saquinavir; Viral Load

2006
Lopinavir/ritonavir or efavirenz plus two nucleoside analogues as first-line antiretroviral therapy: a non-randomized comparison.
    Antiviral therapy, 2006, Volume: 11, Issue:5

    Topics: Adult; Aged; Alkynes; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Disease Progression; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Hypertriglyceridemia; Italy; Lopinavir; Male; Middle Aged; Nucleosides; Prospective Studies; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Failure; Viral Load

2006
Response to "Atazanavir/ritonavir versus lopinavir/ritonavir: equivalent or different efficacy profiles?" by Hill.
    AIDS (London, England), 2006, Oct-03, Volume: 20, Issue:15

    Topics: Atazanavir Sulfate; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Oligopeptides; Patient Selection; Pyridines; Pyrimidinones; Ritonavir; RNA, Viral; Treatment Outcome

2006
Orosomucoid (alpha1-acid glycoprotein) plasma concentration and genetic variants: effects on human immunodeficiency virus protease inhibitor clearance and cellular accumulation.
    Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:4

    Topics: Adult; Alkynes; Benzoxazines; Cohort Studies; Cyclopropanes; Female; Genetic Variation; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lopinavir; Male; Middle Aged; Nelfinavir; Orosomucoid; Oxazines; Phenotype; Pyrimidinones; Ritonavir; Switzerland

2006
A retrospective TDM database analysis of interpatient variability in the pharmacokinetics of lopinavir in HIV-infected adults.
    Therapeutic drug monitoring, 2006, Volume: 28, Issue:5

    Topics: Adolescent; Adult; Aged; Body Weight; Databases, Factual; Drug Monitoring; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Regression Analysis; Retrospective Studies; Tissue Distribution

2006
Ability of different lopinavir genotypic inhibitory quotients to predict 48-week virological response in highly treatment-experienced HIV-infected patients receiving lopinavir/ritonavir.
    Journal of medical virology, 2006, Volume: 78, Issue:12

    Topics: Anti-HIV Agents; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Multivariate Analysis; Predictive Value of Tests; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Treatment Outcome

2006
Abbott expands low cost Kaletra.
    AIDS patient care and STDs, 2006, Volume: 20, Issue:10

    Topics: Developing Countries; Drug Industry; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Private Sector; Pyrimidinones; Ritonavir

2006
The level of persistent HIV viremia does not increase after successful simplification of maintenance therapy to lopinavir/ritonavir alone.
    AIDS (London, England), 2006, Nov-28, Volume: 20, Issue:18

    Topics: Drug Resistance, Viral; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Longitudinal Studies; Lopinavir; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Treatment Failure; Viral Load; Viremia

2006
Measuring below the bar: what is it telling us?
    AIDS (London, England), 2006, Nov-28, Volume: 20, Issue:18

    Topics: Anti-Retroviral Agents; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pyrimidinones; Ritonavir; RNA, Viral

2006
Serious, multi-organ hypersensitivity to lopinavir alone, involving cutaneous-mucous rash, and myeloid, liver, and kidney function.
    AIDS (London, England), 2006, Nov-28, Volume: 20, Issue:18

    Topics: Adult; Antiretroviral Therapy, Highly Active; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Exanthema; Female; HIV Infections; HIV Protease Inhibitors; Humans; Kidney Diseases; Lopinavir; Myelopoiesis; Pyrimidinones

2006
Successful treatment with atazanavir and lopinavir/ritonavir combination therapy in protease inhibitor-susceptible and protease inhibitor-resistant HIV-infected patients.
    AIDS patient care and STDs, 2006, Volume: 20, Issue:11

    Topics: Adult; Aged; Atazanavir Sulfate; Drug Resistance, Multiple, Viral; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Oligopeptides; Pyridines; Pyrimidinones; Retrospective Studies; Ritonavir

2006
Long-term immunologic outcome in HAART-experienced subjects receiving lopinavir/ritonavir.
    AIDS research and human retroviruses, 2006, Volume: 22, Issue:11

    Topics: Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Retrospective Studies; Ritonavir; Time Factors

2006
Nifedipine-lopinavir/ritonavir severe interaction: a case report.
    AIDS (London, England), 2007, Jan-02, Volume: 21, Issue:1

    Topics: Acute Kidney Injury; Anti-HIV Agents; Drug Interactions; HIV Infections; Humans; Hypertension; Lopinavir; Male; Middle Aged; Nifedipine; Pyrimidinones; Ritonavir

2007
XVI International AIDS Conference: Part 2.
    The AIDS reader, 2006, Volume: 16, Issue:11

    Topics: Acquired Immunodeficiency Syndrome; CCR5 Receptor Antagonists; Clinical Trials as Topic; Darunavir; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Organic Chemicals; Pyrimidinones; Pyrrolidinones; Raltegravir Potassium; Receptors, CCR5; Ritonavir; Salvage Therapy; Sulfonamides

2006
[Histoplasmosis leading to diagnosis of HIV infection].
    Presse medicale (Paris, France : 1983), 2006, Volume: 35, Issue:12 Pt 1

    Topics: Adult; AIDS-Related Opportunistic Infections; Amphotericin B; Anti-HIV Agents; Antifungal Agents; Biopsy; Female; Histoplasma; Histoplasmosis; HIV Infections; HIV Protease Inhibitors; Humans; Itraconazole; Lopinavir; Pyrimidinones; Skin; Treatment Outcome

2006
Cost effectiveness of lopinavir/ritonavir compared with atazanavir in antiretroviral-naive patients: modelling the combined effects of HIV and heart disease.
    Clinical drug investigation, 2007, Volume: 27, Issue:1

    Topics: Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Coronary Disease; Cost-Benefit Analysis; Fees, Pharmaceutical; Health Care Costs; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Markov Chains; Models, Statistical; Oligopeptides; Pyridines; Pyrimidinones; Quality-Adjusted Life Years; Ritonavir; Survival Analysis; Survival Rate; Time Factors

2007
Report from the XVI International AIDS Conference. Lopinavir/ritonavir monotherapy.
    AIDS clinical care, 2006, Volume: 18, Issue:11

    Topics: HIV Infections; Humans; Lopinavir; Pilot Projects; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Viral Load

2006
Lopinavir/ritonavir pharmacokinetics in HIV and hepatitis C virus co-infected patients without liver function impairment: influence of liver fibrosis.
    Clinical pharmacokinetics, 2007, Volume: 46, Issue:1

    Topics: Area Under Curve; Chromatography, High Pressure Liquid; Hepatitis C; HIV Infections; HIV Protease Inhibitors; Humans; Liver; Liver Function Tests; Lopinavir; Pyrimidinones; Ritonavir

2007
The use of drug resistance algorithms and genotypic inhibitory quotient in prediction of lopinavir-ritonavir treatment response in human immunodeficiency virus type 1 protease inhibitor-experienced patients.
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2007, Volume: 38, Issue:2

    Topics: Adult; Aged; Algorithms; Cohort Studies; Drug Resistance, Viral; Female; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Retrospective Studies; Ritonavir; Sensitivity and Specificity; Viral Load

2007
Better lipid profile for Invirase.
    AIDS patient care and STDs, 2006, Volume: 20, Issue:12

    Topics: Cholesterol; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Multicenter Studies as Topic; Pyrimidinones; Randomized Controlled Trials as Topic; Saquinavir; Triglycerides

2006
Anti-HIV agents. Once-daily lopinavir/ritonavir (Kaletra).
    TreatmentUpdate, 2004, Volume: 16, Issue:2

    Topics: CD4 Lymphocyte Count; Clinical Trials as Topic; Drug Administration Schedule; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Viral Load

2004
[Lopinavir/ritonavir in HIV-infected patient with long-term virological failure: immunovirological response and tolerance in 121 patients of the ANRS CO8 Aproco-Copilote cohort].
    Medecine et maladies infectieuses, 2007, Volume: 37, Issue:3

    Topics: Anti-HIV Agents; Cohort Studies; Drug Resistance, Viral; Drug Tolerance; Genotype; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pilot Projects; Pyrimidinones; Ritonavir; Treatment Failure

2007
LPV monotherapy: 72-week data.
    IAPAC monthly, 2006, Volume: 12, Issue:1

    Topics: CD4 Lymphocyte Count; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Viral Load

2006
[Kaletra, a new anti HIV agent].
    Revue de l'infirmiere, 2006, Issue:126

    Topics: Anti-HIV Agents; Contraindications; HIV Infections; Humans; Lopinavir; Pyrimidinones

2006
Evidence of ongoing immune reconstitution in subjects with sustained viral suppression following 6 years of lopinavir-ritonavir treatment.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2007, Mar-01, Volume: 44, Issue:5

    Topics: Adult; Anti-HIV Agents; Biomarkers; CD4-CD8 Ratio; Clinical Trials, Phase II as Topic; Cohort Studies; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; RNA, Viral; Stavudine

2007
Integration of atazanavir into an existing liquid chromatography UV method for protease inhibitors: validation and application.
    Therapeutic drug monitoring, 2007, Volume: 29, Issue:1

    Topics: Atazanavir Sulfate; Calibration; Chromatography, High Pressure Liquid; Drug Monitoring; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Oligopeptides; Pyridines; Pyrimidinones; Quality Control; Reference Standards; Reproducibility of Results; Ritonavir; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Time Factors

2007
Plasma lopinavir trough levels in a group of pregnant women on lopinavir, ritonavir, zidovudine, and lamivudine.
    AIDS (London, England), 2007, Mar-12, Volume: 21, Issue:5

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; HIV Infections; HIV Protease Inhibitors; Humans; Infectious Disease Transmission, Vertical; Lamivudine; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Prospective Studies; Pyrimidinones; Ritonavir; Viral Load; Zidovudine

2007
Multidrug resistance 1 polymorphisms and trough concentrations of atazanavir and lopinavir in patients with HIV.
    Pharmacogenomics, 2007, Volume: 8, Issue:3

    Topics: Adult; Aged; Atazanavir Sulfate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Female; Gene Frequency; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Oligopeptides; Polymorphism, Genetic; Pyridines; Pyrimidinones

2007
Induction therapy with enfuvirtide-based highly active antiretroviral therapy in a patient with acute HIV-1 infection.
    AIDS patient care and STDs, 2007, Volume: 21, Issue:2

    Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Deoxycytidine; Emtricitabine; Enfuvirtide; HIV Envelope Protein gp41; HIV Infections; HIV-1; Humans; Lopinavir; Male; Organophosphonates; Peptide Fragments; Pyrimidinones; Ritonavir; Tenofovir; Viral Load; Viremia

2007
Influence of liver fibrosis stage on plasma levels of antiretroviral drugs in HIV-infected patients with chronic hepatitis C.
    The Journal of infectious diseases, 2007, Apr-01, Volume: 195, Issue:7

    Topics: Adult; Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Drug Monitoring; Female; Hepatitis C, Chronic; HIV Infections; Humans; Liver Cirrhosis; Lopinavir; Male; Nevirapine; Oligopeptides; Oxazines; Pyridines; Pyrimidinones; Ritonavir; Severity of Illness Index

2007
Antimalarial activity of sera from subjects taking HIV protease inhibitors.
    AIDS (London, England), 2007, Mar-30, Volume: 21, Issue:6

    Topics: Animals; Antimalarials; Antiretroviral Therapy, Highly Active; Chloroquine; Drug Synergism; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Malaria, Falciparum; Plasmodium falciparum; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Treatment Outcome

2007
Long-term follow-up of 414 HIV-infected Romanian children and adolescents receiving lopinavir/ritonavir-containing highly active antiretroviral therapy.
    Pediatrics, 2007, Volume: 119, Issue:5

    Topics: Adolescent; Antiretroviral Therapy, Highly Active; Child; Child, Preschool; Cohort Studies; Drug Combinations; Female; Follow-Up Studies; HIV Infections; Humans; Lopinavir; Male; Prospective Studies; Pyrimidinones; Ritonavir; Romania

2007
Methadone-induced Torsade de pointes after stopping lopinavir-ritonavir.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2007, Volume: 26, Issue:5

    Topics: Analgesics, Opioid; Anti-Retroviral Agents; Drug Administration Schedule; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; Humans; Lopinavir; Methadone; Middle Aged; Pyrimidinones; Ritonavir; Torsades de Pointes

2007
Steady-state lopinavir levels in third trimester of pregnancy.
    AIDS (London, England), 2007, May-11, Volume: 21, Issue:8

    Topics: Adolescent; Adult; Drug Combinations; Drug Monitoring; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, Third; Pyrimidinones; Ritonavir; Treatment Outcome; Viral Load

2007
HIV-infected patients receiving lopinavir/ritonavir-based antiretroviral therapy achieve high rates of virologic suppression despite adherence rates less than 95%.
    Journal of acquired immune deficiency syndromes (1999), 2007, May-01, Volume: 45, Issue:1

    Topics: Adult; Antiretroviral Therapy, Highly Active; Black People; CD4 Lymphocyte Count; Drug Therapy, Combination; Female; Hispanic or Latino; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Patient Compliance; Pyrimidinones; Retrospective Studies; Ritonavir; Time Factors; Treatment Outcome; Viral Load; White People

2007
Lack of effect of gastric acid-reducing agents on the pharmacokinetics of lopinavir/ritonavir in HIV-infected patients.
    AIDS patient care and STDs, 2007, Volume: 21, Issue:4

    Topics: Adult; Antacids; Area Under Curve; Drug Interactions; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Pyrimidinones; Randomized Controlled Trials as Topic; Ritonavir

2007
Response to "Nifedipine-lopinavir/ritonavir severe interaction: a case report".
    AIDS (London, England), 2007, May-31, Volume: 21, Issue:9

    Topics: Anti-HIV Agents; Antihypertensive Agents; Drug Interactions; HIV Infections; Humans; Lopinavir; Nifedipine; Pyrimidinones; Ritonavir

2007
Pivotal moments in HIV treatment: the 14th CROI.
    The AIDS reader, 2007, Volume: 17, Issue:5

    Topics: Anti-Retroviral Agents; Clinical Trials as Topic; Congresses as Topic; Cyclohexanes; HIV Fusion Inhibitors; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Lopinavir; Maraviroc; Multicenter Studies as Topic; Organic Chemicals; Pyrimidinones; Pyrrolidinones; Raltegravir Potassium; Treatment Outcome; Triazoles; United States

2007
Transmission of multidrug-resistant HIV-1: 5 years of immunological and virological survey.
    AIDS (London, England), 2007, Jun-19, Volume: 21, Issue:10

    Topics: Adenine; Anti-Retroviral Agents; CD4 Lymphocyte Count; Drug Resistance, Multiple, Viral; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Mutation; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Tenofovir; Viral Load

2007
Lopinavir/ritonavir monotherapy as a simplification strategy in routine clinical practice.
    The Journal of antimicrobial chemotherapy, 2007, Volume: 60, Issue:2

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cholesterol; Databases, Factual; Endpoint Determination; Female; Genotype; HIV Infections; Humans; Lipids; Lopinavir; Male; Pyrimidinones; Retrospective Studies; Ritonavir; RNA, Viral; Treatment Outcome

2007
Cost effectiveness of lopinavir/ritonavir compared with atazanavir plus ritonavir in antiretroviral-experienced patients in the US.
    Clinical drug investigation, 2007, Volume: 27, Issue:7

    Topics: Adult; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Coronary Disease; Costs and Cost Analysis; Data Collection; Drug Combinations; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Markov Chains; Models, Statistical; Pyrimidinones; Quality of Life; Quality-Adjusted Life Years; Ritonavir; Survival Analysis; United States; Viral Load

2007
Kaletra single agent HAART after intolerance of NRTI- and NNRTI-containing regimens following kidney transplantation.
    Infection, 2007, Volume: 35, Issue:3

    Topics: Adult; Antiretroviral Therapy, Highly Active; HIV Infections; HIV Protease Inhibitors; Humans; Kidney Transplantation; Lopinavir; Male; Pyrimidinones; Reverse Transcriptase Inhibitors

2007
HPV oral infection. Case report of an HIV-positive Nigerian sex worker.
    Le infezioni in medicina, 2007, Volume: 15, Issue:2

    Topics: Adenine; Adult; Alphapapillomavirus; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Deoxycytidine; Dideoxynucleosides; Emtricitabine; Female; HIV Infections; Humans; Italy; Lamivudine; Lopinavir; Mouth Mucosa; Nigeria; Organophosphonates; Papillomavirus Infections; Pyrimidinones; Ritonavir; Sex Work; Stomatitis; Tenofovir; Treatment Refusal; Zidovudine

2007
Clinical ritonavir and lopinavir hypersensitivity confirmed by a specific in vitro cellular allergen stimulation test.
    Current HIV research, 2007, Volume: 5, Issue:4

    Topics: Adult; Anti-HIV Agents; Drug Hypersensitivity; HIV Infections; Humans; Immunoassay; Lopinavir; Male; Protease Inhibitors; Pyrimidinones; Ritonavir

2007
FDA notifications. FDA grants approval for generic didanosine for oral solution.
    AIDS alert, 2007, Volume: 22, Issue:6

    Topics: Administration, Oral; Didanosine; Dideoxynucleosides; Drugs, Generic; HIV Infections; Humans; Lopinavir; Pyrimidinones; Reverse Transcriptase Inhibitors; Stavudine; United States; United States Food and Drug Administration

2007
Hair loss induced by lopinavir-ritonavir.
    Pharmacotherapy, 2007, Volume: 27, Issue:8

    Topics: Adult; Alkynes; Alopecia; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Dideoxynucleosides; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Lopinavir; Probability; Pyrimidinones; Ritonavir

2007
Plasma concentrations of the HIV-protease inhibitor lopinavir are suboptimal in children aged 2 years and below.
    Antiviral therapy, 2007, Volume: 12, Issue:4

    Topics: Adolescent; Anti-HIV Agents; Area Under Curve; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Infant; Lopinavir; Male; Pyrimidinones; Reverse Transcriptase Inhibitors; RNA, Viral; Treatment Outcome

2007
[Insulin resistance in HIV-infected patients receiving long-term therapy with efavirenz, lopinavir/ritonavir and atazanavir].
    Medicina clinica, 2007, Jul-14, Volume: 129, Issue:7

    Topics: Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Cross-Sectional Studies; Cyclopropanes; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Metabolic Syndrome; Middle Aged; Oligopeptides; Pyridines; Pyrimidinones; Ritonavir; Time Factors

2007
Report from the XVI International HIV Drug Resistance Workshop.
    AIDS clinical care, 2007, Volume: 19, Issue:8

    Topics: Anti-HIV Agents; Cyclohexanes; Drug Resistance, Viral; HIV Fusion Inhibitors; HIV Infections; HIV Integrase Inhibitors; Humans; Lopinavir; Maraviroc; Nitriles; Piperazines; Pyridazines; Pyrimidines; Pyrimidinones; Triazoles

2007
Genotypic resistance to lopinavir and fosamprenavir with or without ritonavir of clinical isolates from patients failing protease inhibitors-containing HAART regimens: prevalence and predictors.
    Scandinavian journal of infectious diseases, 2007, Volume: 39, Issue:9

    Topics: Adult; Algorithms; Antiretroviral Therapy, Highly Active; Carbamates; Drug Resistance, Multiple, Viral; Female; Furans; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Organophosphates; Prevalence; Pyrimidinones; Retrospective Studies; Ritonavir; Sulfonamides

2007
Proteinuria and endothelial dysfunction in stable HIV-infected patients. A pilot study.
    Journal of acquired immune deficiency syndromes (1999), 2007, Aug-15, Volume: 45, Issue:5

    Topics: Adult; Aged; Cross-Sectional Studies; Endothelium, Vascular; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Nitroglycerin; Pilot Projects; Proteinuria; Pyrimidinones; Regional Blood Flow; Ritonavir; Vasodilation

2007
Impact of steady-state lopinavir plasma levels on plasma lipids and body composition after 24 weeks of lopinavir/ritonavir-containing therapy free of thymidine analogues.
    The Journal of antimicrobial chemotherapy, 2007, Volume: 60, Issue:4

    Topics: Absorptiometry, Photon; Adipose Tissue; Adult; Anti-HIV Agents; Blood Chemical Analysis; Body Composition; Female; HIV Infections; Humans; Lipids; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir

2007
Lopinavir-ritonavir dramatically affects the pharmacokinetics of irinotecan in HIV patients with Kaposi's sarcoma.
    Clinical pharmacology and therapeutics, 2008, Volume: 83, Issue:4

    Topics: Adenine; Adult; Aged; Anti-HIV Agents; Antineoplastic Agents, Phytogenic; Antiretroviral Therapy, Highly Active; Area Under Curve; Camptothecin; Drug Therapy, Combination; HIV Infections; Humans; Irinotecan; Lamivudine; Lopinavir; Male; Middle Aged; Organophosphonates; Pyrimidinones; Ritonavir; Sarcoma, Kaposi; Tenofovir; White People

2008
Antiretroviral drug exposure in the female genital tract: implications for oral pre- and post-exposure prophylaxis.
    AIDS (London, England), 2007, Sep-12, Volume: 21, Issue:14

    Topics: Adenine; Administration, Oral; Adult; Alkynes; Anti-Retroviral Agents; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; Genitalia, Female; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Lopinavir; Oligopeptides; Organophosphonates; Pyridines; Pyrimidinones; Reverse Transcriptase Inhibitors; Tenofovir; Zidovudine

2007
Combined tipranavir and enfuvirtide use associated with higher plasma tipranavir concentrations but not with increased hepatotoxicity: sub-analysis from RESIST.
    AIDS (London, England), 2007, Sep-12, Volume: 21, Issue:14

    Topics: Alanine Transaminase; Anti-HIV Agents; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Enfuvirtide; HIV Envelope Protein gp41; HIV Fusion Inhibitors; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Liver Diseases; Lopinavir; Peptide Fragments; Pyridines; Pyrimidinones; Pyrones; Randomized Controlled Trials as Topic; Ritonavir; Saquinavir; Sulfonamides; Treatment Outcome; Viral Load

2007
Alopecia induced by lopinavir plus ritonavir therapy in an HIV patient.
    Journal of drugs in dermatology : JDD, 2007, Volume: 6, Issue:7

    Topics: Alopecia; Antiretroviral Therapy, Highly Active; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Nelfinavir; Pyrimidinones; Ritonavir; Treatment Outcome

2007
Peripheral Neuropathy Induced by Lopinavir-Saquinavir-Ritonavir Combination Therapy in an HIV-Infected Patient.
    Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002), 2007, Volume: 6, Issue:3

    Topics: Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Peripheral Nervous System Diseases; Ritonavir; Saquinavir

2007
Cholesterol levels in HIV-HCV infected patients treated with lopinavir/r: results from the SCOLTA project.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2008, Volume: 62, Issue:1

    Topics: Adult; Anti-HIV Agents; Cholesterol; Cohort Studies; Drug Combinations; Female; Follow-Up Studies; Hepatitis C, Chronic; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Prospective Studies; Pyrimidinones; Ritonavir; Triglycerides

2008
Patient preferences among third agent HIV medications: a US and German perspective.
    AIDS care, 2007, Volume: 19, Issue:8

    Topics: Anti-Retroviral Agents; Drug Administration Schedule; Drug Interactions; Drug Resistance, Viral; Female; Germany; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Patient Satisfaction; Pyrimidinones; Ritonavir; Treatment Outcome; United States

2007
Mutational patterns and correlated amino acid substitutions in the HIV-1 protease after virological failure to nelfinavir- and lopinavir/ritonavir-based treatments.
    Journal of medical virology, 2007, Volume: 79, Issue:11

    Topics: Amino Acid Substitution; Databases, Protein; Drug Resistance, Viral; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Models, Molecular; Mutation; Nelfinavir; Pyrimidinones; Ritonavir; Spain; Treatment Failure

2007
Assessing the impact of substance use and hepatitis coinfection on atazanavir and lopinavir trough concentrations in HIV-infected patients during therapeutic drug monitoring.
    Therapeutic drug monitoring, 2007, Volume: 29, Issue:5

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Drug Administration Schedule; Drug Monitoring; Female; Hepatitis C; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Oligopeptides; Pyridines; Pyrimidinones; Substance-Related Disorders; United States

2007
Aluvia tablet approved in 19 African countries.
    AIDS patient care and STDs, 2007, Volume: 21, Issue:8

    Topics: Africa; Anti-HIV Agents; Drug Approval; Drug Industry; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir; Tablets

2007
Early virologic rebound in a pilot trial of ritonavir-boosted atanazavir as maintenance monotherapy.
    Journal of acquired immune deficiency syndromes (1999), 2007, Sep-01, Volume: 46, Issue:1

    Topics: Anti-HIV Agents; Atazanavir Sulfate; Drug Resistance, Viral; HIV Infections; HIV-1; Humans; Lopinavir; Oligopeptides; Pilot Projects; Pyridines; Pyrimidinones; Ritonavir

2007
Uveitis associated with concurrent administration of rifabutin and lopinavir/ritonavir (Kaletra).
    Eye (London, England), 2007, Volume: 21, Issue:12

    Topics: Adult; Anti-HIV Agents; Antitubercular Agents; Drug Interactions; HIV Infections; Humans; Lopinavir; Male; Panuveitis; Pyrimidinones; Rifabutin; Ritonavir; Tuberculosis, Pulmonary

2007
Darunavir phase 3 study data released.
    AIDS patient care and STDs, 2007, Volume: 21, Issue:10

    Topics: Anti-HIV Agents; Clinical Trials, Phase III as Topic; Darunavir; Drug Therapy, Combination; HIV Infections; Humans; Lopinavir; Pyrimidinones; Ritonavir; Sulfonamides

2007
Pharmacokinetics and pharmacodynamics of combined use of lopinavir/ritonavir and rosuvastatin in HIV-infected patients.
    Antiviral therapy, 2007, Volume: 12, Issue:7

    Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Drug Therapy, Combination; Fluorobenzenes; HIV Infections; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lopinavir; Middle Aged; Pilot Projects; Pyrimidines; Pyrimidinones; Ritonavir; Rosuvastatin Calcium; Sulfonamides

2007
Cost effectiveness of lopinavir/ritonavir tablets compared with atazanavir plus ritonavir in antiretroviral-experienced patients in the UK, France, Italy and Spain.
    Clinical drug investigation, 2007, Volume: 27, Issue:12

    Topics: Adult; Atazanavir Sulfate; Coronary Disease; Cost-Benefit Analysis; Drug Combinations; Drug Therapy, Combination; France; Health Care Costs; HIV Infections; HIV Protease Inhibitors; Humans; Italy; Lopinavir; Male; Markov Chains; Oligopeptides; Pyridines; Pyrimidinones; Quality-Adjusted Life Years; Risk Factors; Ritonavir; Spain; Time Factors; United Kingdom

2007
Long-term response to highly active antiretroviral therapy with lopinavir/ritonavir in pre-treated vertically HIV-infected children.
    The Journal of antimicrobial chemotherapy, 2008, Volume: 61, Issue:1

    Topics: Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Child; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Infectious Disease Transmission, Vertical; Lopinavir; Male; Pyrimidinones; Retrospective Studies; Ritonavir; Time Factors; Treatment Outcome

2008
Treatment response to ritonavir-boosted tipranavir versus ritonavir-boosted lopinavir in HIV-1 patients with higher lopinavir mutation scores.
    AIDS (London, England), 2007, Oct-18, Volume: 21, Issue:16

    Topics: Antiretroviral Therapy, Highly Active; Clinical Trials, Phase III as Topic; Drug Administration Schedule; Drug Resistance, Viral; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Mutation; Pyridines; Pyrimidinones; Pyrones; Ritonavir; RNA, Viral; Sulfonamides; Treatment Outcome; Viral Load

2007
Evolution of bone mineral density in AIDS patients on treatment with zidovudine/lamivudine plus abacavir or lopinavir/ritonavir.
    HIV medicine, 2008, Volume: 9, Issue:2

    Topics: Absorptiometry, Photon; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Bone Density; Case-Control Studies; Dideoxynucleosides; Femur Neck; HIV Infections; Humans; Lamivudine; Lopinavir; Lumbar Vertebrae; Male; Middle Aged; Prospective Studies; Pyrimidinones; Ritonavir; Zidovudine

2008
Prevalence and impact of HIV-1 protease mutation L76V on lopinavir resistance.
    AIDS (London, England), 2008, Jan-11, Volume: 22, Issue:2

    Topics: Antiretroviral Therapy, Highly Active; Codon; Drug Resistance, Multiple, Viral; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Point Mutation; Pyrimidinones; Spain

2008
Effect of rifampicin on lopinavir pharmacokinetics in HIV-infected children with tuberculosis.
    Journal of acquired immune deficiency syndromes (1999), 2008, Apr-15, Volume: 47, Issue:5

    Topics: Antibiotics, Antitubercular; Child, Preschool; Drug Interactions; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Infant; Lopinavir; Male; Pyrimidinones; Rifampin; Ritonavir; Tuberculosis

2008
A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells.
    The Journal of biological chemistry, 2008, Apr-11, Volume: 283, Issue:15

    Topics: Animals; Darunavir; HIV Infections; HIV Protease Inhibitors; Humans; Lamin Type A; Lipodystrophy; Lopinavir; Membrane Proteins; Metabolic Syndrome; Metalloendopeptidases; Mice; Mice, Knockout; Nuclear Proteins; Protein Precursors; Protein Processing, Post-Translational; Pyrimidinones; Ritonavir; Sulfonamides

2008
Virological response to salvage therapy in HIV-infected persons carrying the reverse transcriptase K65R mutation.
    Antiviral therapy, 2007, Volume: 12, Issue:8

    Topics: Adult; Aged; Anti-HIV Agents; Female; HIV Infections; HIV Protease Inhibitors; HIV Reverse Transcriptase; HIV-1; Humans; Italy; Lamivudine; Lopinavir; Male; Middle Aged; Mutation; Pyrimidinones; Retrospective Studies; Ritonavir; RNA, Viral; Salvage Therapy; Thymidine; Treatment Outcome

2007
Predictive factors for response to a boosted dual HIV-protease inhibitor therapy with saquinavir and lopinavir in extensively pre-treated patients.
    Antiviral therapy, 2007, Volume: 12, Issue:8

    Topics: Adult; Aged; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Drug Resistance, Viral; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Ritonavir; Saquinavir; Treatment Outcome; Viral Load

2007
Pharmacokinetic parameters of lopinavir determined by moment analysis in Japanese HIV type 1-infected patients.
    AIDS research and human retroviruses, 2008, Volume: 24, Issue:1

    Topics: Adult; Anti-HIV Agents; Area Under Curve; Drug Therapy, Combination; Female; Half-Life; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Japan; Lopinavir; Male; Middle Aged; Pyrimidinones; Reverse Transcriptase Inhibitors

2008
CYP3A5 genotype has no impact on plasma trough concentrations of lopinavir and ritonavir in HIV-infected subjects.
    Clinical pharmacology and therapeutics, 2008, Volume: 84, Issue:2

    Topics: Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Brazil; Cytochrome P-450 CYP3A; Drug Therapy, Combination; Genotype; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Polymorphism, Genetic; Pyrimidinones; Ritonavir

2008
Anti-HIV agents. Using only lopinavir/ritonavir (Kaletra).
    TreatmentUpdate, 2008, Volume: 20, Issue:1

    Topics: HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Patient Compliance; Pyrimidinones; Ritonavir; Viral Load

2008
Anti-HIV agents. Monotherapy studies--points to consider.
    TreatmentUpdate, 2008, Volume: 20, Issue:1

    Topics: Canada; Drug Resistance, Viral; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Mutation; Pyrimidinones; Ritonavir

2008
Lopinavir/ritonavir monotherapy as maintenance treatment in HIV-infected individuals with virological suppression: results from a pilot study in Brazil.
    HIV medicine, 2008, Volume: 9, Issue:5

    Topics: Adult; Aged; Antiretroviral Therapy, Highly Active; Brazil; CD4 Lymphocyte Count; Cytochrome P-450 CYP3A; Drug Administration Schedule; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pilot Projects; Polymorphism, Genetic; Pyrimidinones; Ritonavir; RNA, Viral; Viral Load; Viremia

2008
[Plasma levels following the switch from amprenavir to fosamprenavir in HIV-infected patients under antiretroviral treatment with lopinavir/ritonavir].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26, Issue:3

    Topics: Adult; Anti-HIV Agents; Carbamates; Drug Therapy, Combination; Female; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Organophosphates; Pyrimidinones; Ritonavir; Sulfonamides

2008
Atazanavir and lopinavir with ritonavir alone or in combination: analysis of pharmacokinetic interaction and predictors of drug exposure.
    HIV medicine, 2008, Volume: 9, Issue:4

    Topics: Adult; Aged; Atazanavir Sulfate; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Oligopeptides; Pilot Projects; Prospective Studies; Pyridines; Pyrimidinones; Ritonavir

2008
Long-term safety and effectiveness of ritonavir, nelfinavir, and lopinavir/ritonavir in antiretroviral-experienced HIV-infected children.
    The Pediatric infectious disease journal, 2008, Volume: 27, Issue:5

    Topics: Adolescent; CD4 Lymphocyte Count; Child; Child, Preschool; Cohort Studies; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Infant; Infant, Newborn; Longitudinal Studies; Lopinavir; Male; Nelfinavir; Pregnancy; Pyrimidinones; Ritonavir; Switzerland; Treatment Outcome; Viral Load; Withholding Treatment

2008
Prospective cohort study of HIV post-exposure prophylaxis for sexual assault survivors.
    Antiviral therapy, 2008, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Child; Child, Preschool; Cohort Studies; Drug Combinations; Female; HIV Infections; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Ontario; Pyrimidinones; Rape; Risk Factors; Zidovudine

2008
FDA notifications. Abbott sends out provider letter about Kaletra for kids.
    AIDS alert, 2007, Volume: 22, Issue:10

    Topics: Child; Drug Industry; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; United States; United States Food and Drug Administration

2007
Ugandan children receive lower-strength Aluvia.
    AIDS patient care and STDs, 2008, Volume: 22, Issue:1

    Topics: Child; Child, Preschool; Developing Countries; Dose-Response Relationship, Drug; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir; Uganda; World Health Organization

2008
[Protease inhibitor Kaletra (Lopinavir/Ritonavir): significance and role in antiretroviral therapy of HIV infection and AIDS].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2007, Volume: 52, Issue:1-2

    Topics: Acquired Immunodeficiency Syndrome; Drug Combinations; Drug Resistance, Viral; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir

2007
Ezetimibe combined with low-dose statin effectively lowers LDL in protease inhibitor treated patients.
    AIDS patient care and STDs, 2008, Volume: 22, Issue:6

    Topics: Adult; Anticholesteremic Agents; Antiretroviral Therapy, Highly Active; Atorvastatin; Azetidines; Cholesterol, LDL; Drug Administration Schedule; Ezetimibe; Female; Follow-Up Studies; Heptanoic Acids; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Hypercholesterolemia; Lopinavir; Male; Middle Aged; Pilot Projects; Pravastatin; Prospective Studies; Pyrroles; Ritonavir; Treatment Outcome

2008
Initial treatment for HIV infection--an embarrassment of riches.
    The New England journal of medicine, 2008, May-15, Volume: 358, Issue:20

    Topics: Alkynes; Benzoxazines; Cyclopropanes; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir

2008
ABT-378 lowers viral load.
    AIDS patient care and STDs, 1999, Volume: 13, Issue:3

    Topics: Anti-HIV Agents; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Viral Load

1999
ABT-378/r helpful in failing patients.
    AIDS patient care and STDs, 2000, Volume: 14, Issue:5

    Topics: Anti-HIV Agents; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Treatment Failure; Viral Load

2000
[New generation protease inhibitor. Tolerance and potency, a tight association].
    MMW Fortschritte der Medizin, 2000, Volume: 142, Issue:3 Suppl

    Topics: Drug Administration Schedule; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Treatment Outcome

2000
From the Food and Drug Administration.
    JAMA, 2000, Nov-01, Volume: 284, Issue:17

    Topics: Adult; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Buprenorphine; Child; Drug and Narcotic Control; Drug Combinations; Drugs, Investigational; HIV Infections; HIV Protease Inhibitors; Humans; Infant; Leukemia, Promyelocytic, Acute; Lopinavir; Opioid-Related Disorders; Oxides; Pyrimidinones; Receptors, Opioid; Ritonavir; United States; United States Food and Drug Administration

2000
FDA approves new protease inhibitor for HIV infection.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2000, Nov-01, Volume: 57, Issue:21

    Topics: Adult; Child; Clinical Trials as Topic; Drug Approval; Drug Combinations; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir; United States; United States Food and Drug Administration

2000
Lopinavir/ritonavir: a protease inhibitor combination.
    The Medical letter on drugs and therapeutics, 2001, Jan-08, Volume: 43, Issue:1095

    Topics: Adolescent; Adult; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Infant; Lopinavir; Pyrimidinones; Ritonavir

2001
Lopinavir.
    Drugs, 2000, Volume: 60, Issue:6

    Topics: Adult; Child; Child, Preschool; Drug Combinations; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Infant; Lopinavir; Molecular Structure; Pyrimidinones; Ritonavir

2000
ATIS site news.
    The AIDS reader, 2000, Volume: 10, Issue:12

    Topics: Anti-HIV Agents; Female; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Lopinavir; Pregnancy; Pregnancy Complications, Infectious; Pyrimidinones

2000
HIV drug-resistance cutoffs available.
    The AIDS reader, 2000, Volume: 10, Issue:12

    Topics: Anti-HIV Agents; Drug Resistance, Microbial; HIV Infections; HIV-1; Humans; Lopinavir; Microbial Sensitivity Tests; Phenotype; Pyrimidinones; Treatment Outcome

2000
ICAAC eyes PIs, NNRTIs, and STIs.
    IAPAC monthly, 2000, Volume: 6, Issue:12

    Topics: Animals; Anti-HIV Agents; Drug Administration Schedule; Drug Interactions; Drug Resistance, Microbial; Drug Therapy, Combination; Drugs, Investigational; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Mutation; Ontario; Pyrimidinones; Reverse Transcriptase Inhibitors; Viral Load

2000
ABT 378/r: a novel inhibitor of HIV-1 protease in haemodialysis.
    AIDS (London, England), 2001, Mar-30, Volume: 15, Issue:5

    Topics: AIDS-Related Opportunistic Infections; Amphotericin B; Antiprotozoal Agents; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Leishmaniasis; Lopinavir; Male; Pyrimidinones; Renal Dialysis; Renal Insufficiency; Ritonavir

2001
Effect of reduced-dose amprenavir in combination with lopinavir on plasma levels of amprenavir in patients infected with HIV.
    Clinical therapeutics, 2001, Volume: 23, Issue:3

    Topics: Adult; Carbamates; Drug Therapy, Combination; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones; Sulfonamides

2001
New drugs in development.
    Project Inform perspective, 1998, Issue:25

    Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Carbamates; CD4 Lymphocyte Count; Clinical Trials as Topic; Cyclopropanes; Dideoxynucleosides; Drug Therapy, Combination; Drugs, Investigational; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Imidazoles; Kidney Diseases; Lopinavir; Oxazines; Pyridines; Pyrimidinones; Reverse Transcriptase Inhibitors; Sulfonamides; Viral Load

1998
Retrovirus conference report: three new agents to the rescue.
    GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies, 1999, Volume: 13, Issue:1

    Topics: Anti-HIV Agents; Carbamates; Congresses as Topic; Drug Resistance, Microbial; Drug Therapy, Combination; Drugs, Investigational; Enfuvirtide; Furans; HIV Envelope Protein gp41; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Peptide Fragments; Pyrimidinones; Salvage Therapy; Sulfonamides; Viral Load; Virus Replication

1999
ABT-378 early access program begins.
    AIDS treatment news, 1999, Oct-01, Issue:No 328

    Topics: Anti-HIV Agents; Clinical Trials as Topic; Drug Approval; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Patient Selection; Pyrimidinones

1999
Upcoming compassionate use programs for two new antiretrovirals will begin this fall.
    STEP perspective, 1999,Fall, Volume: 99, Issue:3

    Topics: Adenine; Anti-HIV Agents; Clinical Trials as Topic; Drug Approval; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Organophosphonates; Organophosphorus Compounds; Patient Selection; Pyrimidinones; Reverse Transcriptase Inhibitors; Tenofovir

1999
ABT-387/r early access program expanded further.
    Research initiative, treatment action : RITA, 1999, Volume: 5, Issue:5

    Topics: Anti-HIV Agents; CD4 Lymphocyte Count; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones

1999
Drug works in treatment-naive, experienced patients.
    AIDS alert, 1999, Volume: 14, Issue:12

    Topics: Clinical Trials, Phase III as Topic; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pyrimidinones; Randomized Controlled Trials as Topic; Ritonavir

1999
Expanded access program for ABT-378 under way.
    Positive living (Los Angeles, Calif.), 1999, Volume: 8, Issue:10

    Topics: Anti-Infective Agents; Clinical Trials as Topic; Drug Approval; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Patient Selection; Pyrimidinones

1999
New anti-HIV drugs in development.
    Project Inform perspective, 1999, Issue:28

    Topics: Adverse Drug Reaction Reporting Systems; Anti-HIV Agents; Capsules; Carbamates; Chemistry, Pharmaceutical; Didanosine; Drug Synergism; Drug Therapy, Combination; Drugs, Investigational; Female; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Menorrhagia; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Sulfonamides

1999
Expanded access.
    Project Inform perspective, 1999, Issue:28

    Topics: Adenine; Anti-HIV Agents; Drug Approval; Drugs, Investigational; Health Services Accessibility; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Organophosphonates; Organophosphorus Compounds; Pyrimidinones; Reverse Transcriptase Inhibitors; Tenofovir

1999
Inflammatory oedema of the legs: a new side-effect of lopinavir.
    AIDS (London, England), 2001, Apr-13, Volume: 15, Issue:6

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Edema; Female; HIV Infections; HIV Protease Inhibitors; Humans; Inflammation; Leg; Lopinavir; Male; Middle Aged; Pyrimidinones

2001
[No resistance even after 1 year. New drug combination against HIV].
    MMW Fortschritte der Medizin, 2001, Apr-02, Volume: 143 Suppl 1

    Topics: Drug Combinations; Drug Resistance, Microbial; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir; Treatment Outcome

2001
[An option even for patients with multiple pretreatment].
    MMW Fortschritte der Medizin, 2001, Apr-02, Volume: 143 Suppl 1

    Topics: Clinical Trials as Topic; Drug Combinations; Drug Resistance, Microbial; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir; Treatment Outcome; Viral Load

2001
[Overcoming weaknesses in therapy. Protease inhibitors with high IQ].
    MMW Fortschritte der Medizin, 2001, Apr-02, Volume: 143 Suppl 1

    Topics: Biological Availability; Drug Administration Schedule; Drug Combinations; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir; Treatment Outcome

2001
Accumulation of lopinavir resistance-associated mutations over 3 years follow-up of patients on highly active antiretroviral therapy: implication in salvage therapy.
    AIDS (London, England), 2001, Jun-15, Volume: 15, Issue:9

    Topics: Antiretroviral Therapy, Highly Active; Drug Resistance, Microbial; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Mutagenesis; Pyrimidinones; Retrospective Studies; Salvage Therapy; Time Factors

2001
Antiretroviral approved for use in infants.
    American family physician, 2001, Jun-15, Volume: 63, Issue:12

    Topics: Drug Approval; Drug Combinations; HIV Infections; HIV Protease Inhibitors; Humans; Infant; Lopinavir; Pyrimidinones; Ritonavir; United States; United States Food and Drug Administration

2001
Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients.
    Journal of virology, 2001, Volume: 75, Issue:16

    Topics: Drug Resistance; Genome, Viral; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Pyrimidinones

2001
Kaletra versus nelfinavir.
    TreatmentUpdate, 2001,Spring, Volume: 12, Issue:12

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Combinations; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Nelfinavir; Pyrimidinones; Ritonavir; Viral Load

2001
Resistant to everything.
    AIDS clinical care, 2001, Volume: 13, Issue:5

    Topics: Aged; Carbamates; CD4 Lymphocyte Count; Dideoxynucleosides; Drug Resistance, Microbial; Drug Therapy, Combination; Furans; HIV Infections; Humans; Lopinavir; Male; Patient Compliance; Pyrimidinones; Ritonavir; Stavudine; Sulfonamides; Viral Load

2001
Pharmacokinetics of amprenavir and lopinavir in combination with nevirapine in highly pretreated HIV-infected patients.
    AIDS (London, England), 2001, Nov-23, Volume: 15, Issue:17

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Carbamates; CD4 Lymphocyte Count; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Nevirapine; Pyrimidinones; Reverse Transcriptase Inhibitors; Sulfonamides; Viral Load

2001
Lopinavir/ritonavir. (Kaletra).
    Research initiative, treatment action : RITA, 2000, Volume: 6, Issue:4

    Topics: Drug Combinations; Drug Interactions; Drug Resistance, Microbial; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Randomized Controlled Trials as Topic; Ritonavir

2000
Unfavourable interaction of amprenavir and lopinavir in combination with ritonavir?
    AIDS (London, England), 2002, Jan-25, Volume: 16, Issue:2

    Topics: Carbamates; Drug Synergism; Drug Therapy, Combination; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Pilot Projects; Pyrimidinones; Ritonavir; Sulfonamides

2002
Kaletra: applying advances in pharmacokinetics to treating HIV.
    HIV clinician, 2001,Winter, Volume: 13, Issue:1

    Topics: Drug Resistance, Microbial; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones

2001
Newest protease inhibitor Kaletra has a unique profile.
    HIV clinician, 2001,Winter, Volume: 13, Issue:1

    Topics: Clinical Trials as Topic; Drug Approval; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Infant; Lopinavir; Pyrimidinones; Reverse Transcriptase Inhibitors

2001
Drug resistance test shows encouraging results.
    AIDS alert, 2002, Volume: 17, Issue:2

    Topics: Drug Combinations; Drug Resistance, Microbial; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir

2002
Inflammatory oedema associated with lopinavir-including HAART regimens in advanced HIV-1 infection: report of 3 cases.
    AIDS (London, England), 2002, Mar-08, Volume: 16, Issue:4

    Topics: Adult; Antiretroviral Therapy, Highly Active; Edema; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Pyrimidinones

2002
Drug interaction between amprenavir and lopinavir/ritonavir in salvage therapy.
    AIDS (London, England), 2002, Mar-29, Volume: 16, Issue:5

    Topics: Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir; Salvage Therapy; Sulfonamides

2002
Delavirdine increases drug exposure of ritonavir-boosted protease inhibitors.
    AIDS (London, England), 2002, Mar-29, Volume: 16, Issue:5

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Carbamates; Delavirdine; Drug Synergism; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Sulfonamides

2002
High-performance liquid chromatographic method for the simultaneous determination of the six HIV-protease inhibitors and two non-nucleoside reverse transcriptase inhibitors in human plasma.
    Therapeutic drug monitoring, 2002, Volume: 24, Issue:3

    Topics: Alkynes; Benzoxazines; Carbamates; Chromatography, High Pressure Liquid; Cyclopropanes; Drug Monitoring; Furans; HIV Infections; Humans; Indinavir; Lopinavir; Nelfinavir; Nevirapine; Oxazines; Protease Inhibitors; Pyrimidinones; Reproducibility of Results; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Sulfonamides

2002
[After 3 years no resistance development. Protease inhibitor with staying power].
    MMW Fortschritte der Medizin, 2002, Apr-09, Volume: 144 Suppl 1

    Topics: Acquired Immunodeficiency Syndrome; Clinical Trials as Topic; Drug Resistance, Viral; Drug Therapy, Combination; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Pyrimidinones; Ritonavir

2002
In vitro antiviral interaction of lopinavir with other protease inhibitors.
    Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:7

    Topics: Anti-HIV Agents; Drug Therapy, Combination; HIV; HIV Infections; HIV Protease Inhibitors; Lopinavir; Microbial Sensitivity Tests; Pyrimidinones

2002
Increasing choices for HIV therapy.
    The New England journal of medicine, 2002, Jun-27, Volume: 346, Issue:26

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Nelfinavir; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir

2002