loperamide has been researched along with Torsade de Pointes in 12 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "High-dose loperamide is often used for the acute management of chemotherapy-induced diarrhea, with a maximum daily dosing of up to 24 mg." | 8.98 | Loperamide and cardiac events: Is high-dose use still safe for chemotherapy-induced diarrhea? ( de Lemos, ML; Guenter, J; Kletas, V, 2018) |
| "The anti-diarrheal drug loperamide is a mu-opioid agonist with poor systemic bioavailability at standard doses." | 5.56 | [Torsade de pointes following repeated massive loperamide ingestions]. ( Carlsson, H; Höjer, J; Myllymäki, L; Westerbergh, J, 2020) |
| "High-dose loperamide is often used for the acute management of chemotherapy-induced diarrhea, with a maximum daily dosing of up to 24 mg." | 4.98 | Loperamide and cardiac events: Is high-dose use still safe for chemotherapy-induced diarrhea? ( de Lemos, ML; Guenter, J; Kletas, V, 2018) |
| "Loperamide overdose may cause QT prolongation, life-threatening arrhythmias/cardiogenic shock, or cardiac arrest." | 1.62 | Loperamide-induced cardiotoxicity: a case overlooked? ( Aqeel, M; Fayyaz, SM; Iqbal, S; Saeed, Y, 2021) |
| "The anti-diarrheal drug loperamide is a mu-opioid agonist with poor systemic bioavailability at standard doses." | 1.56 | [Torsade de pointes following repeated massive loperamide ingestions]. ( Carlsson, H; Höjer, J; Myllymäki, L; Westerbergh, J, 2020) |
| "Loperamide is an over-the-counter, inexpensive, antidiarrheal opioid that can produce life-threatening toxicity at high concentrations." | 1.46 | Loperamide-Induced Torsades de Pointes: A Case Series. ( Amaducci, A; Burket, G; Cannon, RD; Cook, MD; Day, R; Enyart, J; Janssen, J; Katz, KD; Porter, L; Roach, T; Williams, KE, 2017) |
| "Loperamide is a μ-opioid receptor agonist commonly used to treat diarrhea and often available as an over-the-counter medication." | 1.43 | Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic. ( Compton, DR; Kang, J; Rampe, D; Vaz, RJ, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 5 (41.67) | 2.80 |
| Authors | Studies |
|---|---|
| Myllymäki, L | 1 |
| Westerbergh, J | 1 |
| Carlsson, H | 1 |
| Höjer, J | 1 |
| Sahu, KK | 1 |
| El Meligy, A | 1 |
| Mishra, AK | 1 |
| Goyal, S | 1 |
| Jackson, GG | 1 |
| Lopez, CR | 1 |
| Bermudez, ES | 1 |
| Hill, NE | 1 |
| Roden, DM | 1 |
| Ely, EW | 1 |
| Stollings, JL | 1 |
| Simon, M | 1 |
| Rague, J | 1 |
| Iqbal, S | 1 |
| Fayyaz, SM | 1 |
| Saeed, Y | 1 |
| Aqeel, M | 1 |
| de Lemos, ML | 1 |
| Guenter, J | 1 |
| Kletas, V | 1 |
| Katz, KD | 1 |
| Cannon, RD | 1 |
| Cook, MD | 1 |
| Amaducci, A | 1 |
| Day, R | 1 |
| Enyart, J | 1 |
| Burket, G | 1 |
| Porter, L | 1 |
| Roach, T | 1 |
| Janssen, J | 1 |
| Williams, KE | 1 |
| Krieg, B | 1 |
| Goodnough, R | 1 |
| Nomura, M | 1 |
| Badea, A | 1 |
| Lynch, KL | 1 |
| Benowitz, NL | 1 |
| Tsutaoka, B | 1 |
| White, CM | 1 |
| Vaughn, P | 1 |
| Solik, MM | 1 |
| Bagga, S | 1 |
| Padanilam, BJ | 1 |
| Kang, J | 1 |
| Compton, DR | 1 |
| Vaz, RJ | 1 |
| Rampe, D | 1 |
2 reviews available for loperamide and Torsade de Pointes
| Article | Year |
|---|---|
Loperamide and cardiac events: Is high-dose use still safe for chemotherapy-induced diarrhea?
Topics: Antidiarrheals; Arrhythmias, Cardiac; Diarrhea; Dose-Response Relationship, Drug; Female; Heart Arre | 2018 |
Loperamide: A Readily Available but Dangerous Opioid Substitute.
Topics: Analgesics, Opioid; Animals; Antidiarrheals; Humans; Loperamide; Naloxone; Substance Withdrawal Synd | 2019 |
10 other studies available for loperamide and Torsade de Pointes
| Article | Year |
|---|---|
[Torsade de pointes following repeated massive loperamide ingestions].
Topics: Antidiarrheals; Arrhythmias, Cardiac; Electrocardiography; Heart Diseases; Humans; Long QT Syndrome; | 2020 |
A tale of twists: loperamide-induced torsades de pointes and ventricular tachycardia storm.
Topics: Aged; Electrocardiography; Humans; Loperamide; Male; Torsades de Pointes; Ventricular Fibrillation | 2020 |
Loperamide Induced Recurrent Torsades de Pointes: A Case Report.
Topics: Adult; Analgesics, Opioid; DNA-Binding Proteins; Electrocardiography; Heart Arrest; Humans; Isoprote | 2022 |
A Case Report of Torsade de Pointes and Brugada Pattern Associated with Loperamide Misuse and Supratherapeutic Loperamide Concentrations.
Topics: Adult; Antidiarrheals; Arrhythmias, Cardiac; Humans; Long QT Syndrome; Loperamide; Male; Torsades de | 2021 |
Loperamide-induced cardiotoxicity: a case overlooked?
Topics: Drug Overdose; Electric Countershock; Electrocardiography; Humans; Long QT Syndrome; Loperamide; Mal | 2021 |
Loperamide-Induced Torsades de Pointes: A Case Series.
Topics: Adult; Antidiarrheals; Drug Overdose; Female; Humans; Loperamide; Male; Torsades de Pointes | 2017 |
Topics: Buprenorphine; Drug Interactions; Germany; Humans; Loperamide; Methadone; Opiate Substitution Treatm | 2016 |
Loperamide associated torsades de pointes, in the setting of complete heart block at marginally supratherapeutic dosing (20mg/day).
Topics: Cardiotoxicity; Heart Block; Humans; Loperamide; Male; Middle Aged; Torsades de Pointes | 2019 |
Electrocardiographic Abnormalities, Malignant Ventricular Arrhythmias, and Cardiomyopathy Associated With Loperamide Abuse.
Topics: Action Potentials; Antidiarrheals; Cardiomyopathy, Dilated; Electrocardiography; Heart Conduction Sy | 2016 |
Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic.
Topics: Action Potentials; Antidiarrheals; Cardiotoxicity; Dose-Response Relationship, Drug; ERG1 Potassium | 2016 |