loperamide has been researched along with Muscle Contraction in 36 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lubeluzole, a neuroprotective anti-ischemic drug, was tested for its ability to act as both antibiotic chemosensitizing and antipropulsive agent for the treatment of infectious diarrhea." | 8.02 | Lubeluzole: from anti-ischemic drug to preclinical antidiarrheal studies. ( Budriesi, R; Caputo, L; Cavalluzzi, MM; Corazza, I; De Salvia, MA; Franchini, C; Gualdani, R; Lentini, G; Micucci, M; Milani, G; Piarulli, M; Quintieri, L; Rosato, A; Viale, M, 2021) |
| " Constipation was induced in rats with loperamide." | 8.02 | 7,8-Dihydroxyflavone Enhanced Colonic Cholinergic Contraction and Relieved Loperamide-Induced Constipation in Rats. ( Han, L; Han, Q; He, B; He, J; Luan, X; Ma, L; Qu, Z; Sun, Y; Wang, B; Xu, L, 2021) |
| "Lubeluzole, a neuroprotective anti-ischemic drug, was tested for its ability to act as both antibiotic chemosensitizing and antipropulsive agent for the treatment of infectious diarrhea." | 4.02 | Lubeluzole: from anti-ischemic drug to preclinical antidiarrheal studies. ( Budriesi, R; Caputo, L; Cavalluzzi, MM; Corazza, I; De Salvia, MA; Franchini, C; Gualdani, R; Lentini, G; Micucci, M; Milani, G; Piarulli, M; Quintieri, L; Rosato, A; Viale, M, 2021) |
| " Constipation was induced in rats with loperamide." | 4.02 | 7,8-Dihydroxyflavone Enhanced Colonic Cholinergic Contraction and Relieved Loperamide-Induced Constipation in Rats. ( Han, L; Han, Q; He, B; He, J; Luan, X; Ma, L; Qu, Z; Sun, Y; Wang, B; Xu, L, 2021) |
| "Experimental antidiarrheal activity of a traditionally used medication, Salicairine, was demonstrated in comparison to loperamide by significant inhibition of castor oil-induced diarrhea in mice (increases in hard faeces/total faeces ratio of 38 and 54 and 5 and 54% with respect to controls, at 0." | 3.70 | Experimental study of antidiarrheal activity of Salicairine. ( Brun, Y; Demenge, P; Sevenet, T; Wang, XP; Willemot, J, 1998) |
| " serraefolia significantly delayed the onset of tonic seizures induced by strychnine and pentylenetetrazol; besides, it diminished the death rate and number of animals that exhibited convulsions." | 3.69 | Evaluation of the calcium-antagonist, antidiarrhoeic and central nervous system activities of Baccharis serraefolia. ( Aguilar-Santamaría, L; Tortoriello, J, 1996) |
| "Loperamide, a new antidiarrhoeal compound, effectively antagonised prostaglandin induced diarrhoea in adult healthy male volunteers and in patients undergoing pregnancy termination with prostaglandins." | 3.65 | The effect of loperamide on prostaglandin induced diarrhoea in rat and man. ( Adaikan, PG; Karim, SM, 1977) |
| " Compound 4a showed no analgesic activity as measured by the mouse abdominal irritant test (MAIT) when dosed at 100 mg/kg, sc, but did show significant MAIT activity at doses of both 10 microg (40% inhibition) and 100 microg (100% inhibition) when dosed intracerebroventricularly (icv)." | 1.32 | Rationale, design, and synthesis of novel phenyl imidazoles as opioid receptor agonists for gastrointestinal disorders. ( Breslin, HJ; Colburn, RW; Coutinho, SV; He, W; Kimball, ES; Li, J; Martinez, RP; Miskowski, TA; Palmer, JM; Rafferty, BM; Schneider, CR; Stone, DJ; Wallace, NH; Zhang, SP, 2004) |
| "Pretreatment with naloxone (0." | 1.28 | In vivo motor effects of loperamide on the rat urinary bladder. ( Berggren, A; Rubenson, A; Sillén, U, 1992) |
| "Loperamide was tested on electrically-evoked contractions using a series of "in vitro" isolated preparations, in comparison with morphine, met-enkephalin, beta-endorphin, ethylketocyclazocine used as representative agonists of mu, delta, epsilon, kappa receptors respectively." | 1.27 | Loperamide: evidence of interaction with mu and delta opioid receptors. ( Casiraghi, L; Giagnoni, G; Gori, E; Parolaro, D; Revel, L; Sala, M; Senini, R, 1983) |
| "Dextromethorphan (DM) was tested for its effect on the contractility of the guinea pig ileum in vitro." | 1.27 | Effect of dextromethorphan on guinea pig ileal contractility in vitro: comparison with levomethorphan, loperamide and codeine. ( Gaginella, TS; Kachur, JF; Morgan, DW, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (50.00) | 18.7374 |
| 1990's | 8 (22.22) | 18.2507 |
| 2000's | 3 (8.33) | 29.6817 |
| 2010's | 4 (11.11) | 24.3611 |
| 2020's | 3 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Breslin, HJ | 1 |
| Miskowski, TA | 1 |
| Rafferty, BM | 1 |
| Coutinho, SV | 1 |
| Palmer, JM | 1 |
| Wallace, NH | 1 |
| Schneider, CR | 1 |
| Kimball, ES | 1 |
| Zhang, SP | 1 |
| Li, J | 1 |
| Colburn, RW | 1 |
| Stone, DJ | 1 |
| Martinez, RP | 1 |
| He, W | 1 |
| Grieco, P | 1 |
| Giusti, L | 1 |
| Carotenuto, A | 1 |
| Campiglia, P | 1 |
| Calderone, V | 1 |
| Lama, T | 1 |
| Gomez-Monterrey, I | 1 |
| Tartaro, G | 1 |
| Mazzoni, MR | 1 |
| Novellino, E | 1 |
| Heitmann, PT | 1 |
| Keightley, L | 1 |
| Wiklendt, L | 1 |
| Wattchow, DA | 1 |
| Brookes, SSJ | 1 |
| Spencer, NJ | 1 |
| Costa, M | 1 |
| Dinning, PG | 1 |
| Cavalluzzi, MM | 1 |
| Budriesi, R | 1 |
| De Salvia, MA | 1 |
| Quintieri, L | 1 |
| Piarulli, M | 1 |
| Milani, G | 1 |
| Gualdani, R | 1 |
| Micucci, M | 1 |
| Corazza, I | 1 |
| Rosato, A | 1 |
| Viale, M | 1 |
| Caputo, L | 1 |
| Franchini, C | 1 |
| Lentini, G | 1 |
| Ma, L | 1 |
| Qu, Z | 1 |
| Xu, L | 1 |
| Han, L | 1 |
| Han, Q | 1 |
| He, J | 1 |
| Luan, X | 1 |
| Wang, B | 1 |
| Sun, Y | 1 |
| He, B | 1 |
| Lee, MJ | 1 |
| Cho, KH | 1 |
| Park, HM | 1 |
| Sung, HJ | 1 |
| Choi, S | 1 |
| Im, W | 1 |
| Shimoyama, T | 1 |
| Takahashi, R | 1 |
| Kimura, M | 1 |
| Fukuda, Y | 1 |
| Shah, AJ | 2 |
| Gowani, SA | 1 |
| Zuberi, AJ | 1 |
| Ghayur, MN | 1 |
| Gilani, AH | 2 |
| Bhulani, NN | 1 |
| Khan, SH | 1 |
| Ur Rehman, N | 1 |
| Otto, B | 1 |
| Mawe, GM | 1 |
| Riepl, RL | 1 |
| Latour, A | 1 |
| Bueno, L | 2 |
| Germany, A | 1 |
| Merino, A | 1 |
| Contreras, E | 1 |
| Giagnoni, G | 1 |
| Casiraghi, L | 1 |
| Senini, R | 1 |
| Revel, L | 1 |
| Parolaro, D | 1 |
| Sala, M | 1 |
| Gori, E | 1 |
| Burleigh, DE | 2 |
| D'Mello, A | 1 |
| Reynolds, IJ | 1 |
| Gould, RJ | 1 |
| Snyder, SH | 1 |
| Honda, H | 1 |
| Iwata, T | 1 |
| Takagi, S | 1 |
| Bando, K | 1 |
| Yamamoto, K | 1 |
| Takase, H | 1 |
| Abe, K | 1 |
| Saito, Y | 1 |
| Suzuki, A | 1 |
| Tortoriello, J | 1 |
| Aguilar-Santamaría, L | 1 |
| Brun, Y | 1 |
| Wang, XP | 1 |
| Willemot, J | 1 |
| Sevenet, T | 1 |
| Demenge, P | 1 |
| Mackerer, CR | 3 |
| Clay, GA | 3 |
| Dajani, EZ | 2 |
| Lin, TK | 1 |
| Brougham, LR | 1 |
| East, PF | 1 |
| Bloss, JL | 1 |
| Muramatsu, I | 1 |
| Fujiwara, M | 1 |
| Shikimi, T | 1 |
| Nakashima, M | 1 |
| Sohji, Y | 2 |
| Kawashima, K | 1 |
| Shimizu, M | 1 |
| Yagasaki, O | 1 |
| Suzuki, H | 1 |
| Karim, SM | 1 |
| Adaikan, PG | 1 |
| Berggren, A | 2 |
| Sillén, U | 2 |
| Rubenson, A | 2 |
| Sarna, SK | 1 |
| Otterson, MF | 1 |
| Hopman, WP | 1 |
| Rosenbusch, G | 1 |
| Jansen, JB | 1 |
| Lamers, CB | 1 |
| Maas, CL | 1 |
| Leek, BF | 1 |
| Jivegård, L | 1 |
| Svanvik, J | 1 |
| Fioramonti, J | 1 |
| Fargeas, MJ | 1 |
| Kachur, JF | 1 |
| Morgan, DW | 1 |
| Gaginella, TS | 1 |
| Song, GX | 1 |
| Zhang, YJ | 1 |
| Zhang, L | 1 |
| Ren, MY | 1 |
| Chu, YH | 1 |
1 review available for loperamide and Muscle Contraction
| Article | Year |
|---|---|
Neural and pharmacologic factors affecting motility of the internal anal sphincter.
Topics: Acetylcholine; Adenosine Triphosphate; Anal Canal; Animals; Autonomic Nervous System; Bethanechol Co | 1983 |
1 trial available for loperamide and Muscle Contraction
| Article | Year |
|---|---|
Effect of increasing oral doses of loperamide on gallbladder motility in man.
Topics: Adult; Cholecystokinin; Dose-Response Relationship, Drug; Female; Gallbladder; Humans; Infusions, In | 1990 |
34 other studies available for loperamide and Muscle Contraction
| Article | Year |
|---|---|
Rationale, design, and synthesis of novel phenyl imidazoles as opioid receptor agonists for gastrointestinal disorders.
Topics: Abdominal Muscles; Analgesics; Animals; CHO Cells; Cricetinae; Gastrointestinal Diseases; Gastrointe | 2004 |
Morphiceptin analogues containing a dipeptide mimetic structure: an investigation on the bioactive topology at the mu-receptor.
Topics: Animals; Binding Sites; Brain; Computer Simulation; Dipeptides; Endorphins; Guinea Pigs; Ileum; In V | 2005 |
The effects of loperamide on excitatory and inhibitory neuromuscular function in the human colon.
Topics: Animals; Colon; Electric Stimulation; Gastrointestinal Motility; Humans; Loperamide; Muscle Contract | 2022 |
Lubeluzole: from anti-ischemic drug to preclinical antidiarrheal studies.
Topics: Animals; Anti-Bacterial Agents; Antidiarrheals; Bacteria; Colon; Diarrhea; Dose-Response Relationshi | 2021 |
7,8-Dihydroxyflavone Enhanced Colonic Cholinergic Contraction and Relieved Loperamide-Induced Constipation in Rats.
Topics: Animals; Colon; Constipation; Defecation; Disease Models, Animal; Flavones; Gastrointestinal Motilit | 2021 |
Pharmacological profile of DA-6886, a novel 5-HT4 receptor agonist to accelerate colonic motor activity in mice.
Topics: Animals; Benzamides; Carbachol; Colon; Esophagus; Gastrointestinal Motility; Loperamide; Male; Mice, | 2014 |
Study of the mechanisms of a Japanese traditional fermented medicine in the improvement of constipation.
Topics: Animals; Aspergillus oryzae; Butyric Acid; Constipation; Dose-Response Relationship, Drug; Fatty Aci | 2015 |
Antidiarrhoeal and spasmolytic activities of the methanolic crude extract of Alstonia scholaris L. are mediated through calcium channel blockade.
Topics: Alstonia; Animals; Antidiarrheals; Calcium; Calcium Channel Blockers; Calcium Channels; Diarrhea; Fe | 2010 |
Calcium channel blocking activity of Mentha longifolia L. explains its medicinal use in diarrhoea and gut spasm.
Topics: Animals; Antidiarrheals; Calcium; Calcium Channel Blockers; Castor Oil; Cations; Diarrhea; Jejunum; | 2010 |
mu-Opiate receptor agonist loperamide blocks bethanechol-induced gallbladder contraction, despite higher cholecystokinin plasma levels in man.
Topics: Adult; Bethanechol; Cholecystokinin; Cross-Over Studies; Gallbladder; Humans; Loperamide; Male; Musc | 2005 |
A micro-computerised system to measure the colonic contractile activity: application to pharmacological tests in dogs.
Topics: Animals; Atropine; Computers; Dogs; Electrophysiology; Gastrointestinal Motility; Intestines; Lopera | 1980 |
Naloxone prevents loperamide inhibition of neurotransmitter induced contractions in rat vas deferens.
Topics: Acetylcholine; Animals; Dopamine Antagonists; Loperamide; Male; Muscle Contraction; Muscle, Smooth; | 1983 |
Loperamide: evidence of interaction with mu and delta opioid receptors.
Topics: Animals; Female; Guinea Pigs; Ileum; Loperamide; Male; Mice; Morphine; Muscle Contraction; Myenteric | 1983 |
Loperamide: blockade of calcium channels as a mechanism for antidiarrheal effects.
Topics: Animals; Antidiarrheals; Calcium; Calcium Channel Blockers; Guinea Pigs; Ileum; In Vitro Techniques; | 1984 |
Comparative effects of loperamide hydrochloride on prostaglandin E1-induced contraction in isolated fundus and ileum of guinea pigs.
Topics: Alprostadil; Animals; Calcium Chloride; Gastric Fundus; Guinea Pigs; Ileum; In Vitro Techniques; Iso | 1994 |
[Pharmacological studies on antidiarrheal effects of a preparation containing berberine and geranii herba].
Topics: Animals; Antidiarrheals; Berberine; Creosote; Drug Combinations; Drugs, Chinese Herbal; Guinea Pigs; | 1993 |
Evaluation of the calcium-antagonist, antidiarrhoeic and central nervous system activities of Baccharis serraefolia.
Topics: Administration, Oral; Analysis of Variance; Animals; Antidiarrheals; Calcium; Convulsants; Dose-Resp | 1996 |
Experimental study of antidiarrheal activity of Salicairine.
Topics: Acetylcholine; Alprostadil; Animals; Antidiarrheals; Barium Compounds; Bisacodyl; Body Water; Castor | 1998 |
Loperamide binding to opiate receptor sites of brain and myenteric plexus.
Topics: Analgesics, Opioid; Animals; Brain; Electric Stimulation; Female; Gastrointestinal Motility; Guinea | 1976 |
Interaction of loperamide with [3H]naloxone binding sites in guinea pig brain and myenteric plexus.
Topics: Animals; Binding Sites; Brain; Drug Interactions; Electric Stimulation; Female; Guinea Pigs; Ileum; | 1977 |
Antidiarrheal and central nervous system activities of SC-27166 (2-[3 - 5 - methyl - 1, 3, 4 - oxadiazol - 2 - yl) - 3, 3 - diphenylpropyl] - 2 - azabicyclo [2.2.2]octane), a new antidiarrheal agent, resulting from binding to opiate receptor sites of brai
Topics: Animals; Antidiarrheals; Brain; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Central Nervous S | 1977 |
Effects of loperamide on the guinea pig taenia coli.
Topics: Acetylcholine; Animals; Colon; Drug Interactions; Electric Stimulation; Female; Guinea Pigs; In Vitr | 1979 |
[Pharmacological studies of loperamide, an anti-diarrheal agent. III. Interaction between loperamide and various agonists in the guinea pig intestine (author's transl)].
Topics: Acetylcholine; Animals; Antidiarrheals; Barium; Bradykinin; Calcium; Guinea Pigs; Histamine Antagoni | 1978 |
Effects of loperamide on acetylcholine and prostaglandin release from isolated guinea pig ileum.
Topics: Acetylcholine; Animals; Depression, Chemical; Guinea Pigs; Ileum; In Vitro Techniques; Intestinal Mu | 1978 |
The effect of loperamide on prostaglandin induced diarrhoea in rat and man.
Topics: Abortion, Induced; Animals; Cricetinae; Diarrhea; Drug Evaluation, Preclinical; Female; Humans; Lope | 1977 |
In vivo motor effects of loperamide on the rat urinary bladder.
Topics: Acetylcholine; Animals; Drug Interactions; Electric Stimulation; Injections, Intra-Arterial; Loperam | 1992 |
Small intestinal amyogenesia and dysmyogenesia induced by morphine and loperamide.
Topics: Animals; Atropine; Dogs; Female; Gastrointestinal Motility; Hexamethonium; Hexamethonium Compounds; | 1990 |
Motor effects of loperamide on rat urinary bladder: an in vitro study.
Topics: Animals; Calcium; Electric Stimulation; In Vitro Techniques; Loperamide; Male; Muscle Contraction; N | 1991 |
Central and local actions of opioids upon reticulo-ruminal motility in sheep.
Topics: Animals; Bradykinin; Enkephalins; Gastrointestinal Motility; In Vitro Techniques; Loperamide; Morphi | 1985 |
Opioid and non-opioid actions of loperamide on cholinergic nerve function in human isolated colon.
Topics: Acetylcholine; Action Potentials; Calcium; Colon; Humans; In Vitro Techniques; Loperamide; Morphine; | 1988 |
The influence of morphine, loperamide and naloxone on gallbladder response to prostaglandin E2 in the anaesthetized cat.
Topics: Animals; Cats; Cholecystitis; Dinoprostone; Female; Gallbladder; Loperamide; Male; Morphine; Muscle | 1986 |
Stimulation of gastrointestinal motility by loperamide in dogs.
Topics: Administration, Oral; Animals; Colon; Dogs; Gastrointestinal Motility; Injections, Intraventricular; | 1987 |
Effect of dextromethorphan on guinea pig ileal contractility in vitro: comparison with levomethorphan, loperamide and codeine.
Topics: Actins; Adenosine Triphosphate; Animals; Calcium; Calmodulin; Codeine; Dextromethorphan; Electric St | 1986 |
[Effect of loperamide on 15-methyl-PGF2 alpha induced diarrhea and its uterine-stimulating action].
Topics: Animals; Carboprost; Diarrhea; Female; Loperamide; Male; Mice; Muscle Contraction; Piperidines; Rats | 1985 |