loperamide has been researched along with Long QT Syndrome in 9 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The anti-diarrheal drug loperamide is a mu-opioid agonist with poor systemic bioavailability at standard doses." | 5.56 | [Torsade de pointes following repeated massive loperamide ingestions]. ( Carlsson, H; Höjer, J; Myllymäki, L; Westerbergh, J, 2020) |
| "Loperamide is a nonprescription medication commonly used to treat diarrhea." | 2.82 | Loperamide Cardiac Toxicity: Pathophysiology, Presentation, and Management. ( Juurlink, DN; Wu, PE, 2022) |
| "Loperamide overdose may cause QT prolongation, life-threatening arrhythmias/cardiogenic shock, or cardiac arrest." | 1.62 | Loperamide-induced cardiotoxicity: a case overlooked? ( Aqeel, M; Fayyaz, SM; Iqbal, S; Saeed, Y, 2021) |
| "The anti-diarrheal drug loperamide is a mu-opioid agonist with poor systemic bioavailability at standard doses." | 1.56 | [Torsade de pointes following repeated massive loperamide ingestions]. ( Carlsson, H; Höjer, J; Myllymäki, L; Westerbergh, J, 2020) |
| "Loperamide is a readily accessible nonprescription medication that is increasingly being used surreptitiously as an opioid substitute to alleviate the symptoms of acute opioid withdrawal." | 1.51 | Loperamide misuse to avoid opioid withdrawal and to achieve a euphoric effect: high doses and high risk. ( Alexander, A; Brent, J; Calello, DP; Campleman, S; Lee, VR; Nelson, LS; Ruck, B; Vera, A; Wax, P, 2019) |
| "Loperamide is an over-the-counter, peripherally acting, μ-opioid receptor agonist used for the treatment of diarrhea." | 1.46 | Loperamide metabolite-induced cardiomyopathy and QTc prolongation. ( Bhatti, Z; Norsworthy, J; Szombathy, T, 2017) |
| "Loperamide is a μ-opioid receptor agonist commonly used to treat diarrhea and often available as an over-the-counter medication." | 1.43 | Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic. ( Compton, DR; Kang, J; Rampe, D; Vaz, RJ, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 4 (44.44) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, PE | 1 |
| Juurlink, DN | 1 |
| Myllymäki, L | 1 |
| Westerbergh, J | 1 |
| Carlsson, H | 1 |
| Höjer, J | 1 |
| Simon, M | 1 |
| Rague, J | 1 |
| Iqbal, S | 1 |
| Fayyaz, SM | 1 |
| Saeed, Y | 1 |
| Aqeel, M | 1 |
| Bhatti, Z | 1 |
| Norsworthy, J | 1 |
| Szombathy, T | 1 |
| Nattel, S | 1 |
| Lee, VR | 1 |
| Vera, A | 1 |
| Alexander, A | 1 |
| Ruck, B | 1 |
| Nelson, LS | 1 |
| Wax, P | 1 |
| Campleman, S | 1 |
| Brent, J | 1 |
| Calello, DP | 1 |
| Enakpene, EO | 1 |
| Riaz, IB | 1 |
| Shirazi, FM | 1 |
| Raz, Y | 1 |
| Indik, JH | 1 |
| Kang, J | 1 |
| Compton, DR | 1 |
| Vaz, RJ | 1 |
| Rampe, D | 1 |
1 review available for loperamide and Long QT Syndrome
| Article | Year |
|---|---|
Loperamide Cardiac Toxicity: Pathophysiology, Presentation, and Management.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Humans; Long QT Syndrome; Loperamide; Opioid-Related Disor | 2022 |
8 other studies available for loperamide and Long QT Syndrome
| Article | Year |
|---|---|
[Torsade de pointes following repeated massive loperamide ingestions].
Topics: Antidiarrheals; Arrhythmias, Cardiac; Electrocardiography; Heart Diseases; Humans; Long QT Syndrome; | 2020 |
A Case Report of Torsade de Pointes and Brugada Pattern Associated with Loperamide Misuse and Supratherapeutic Loperamide Concentrations.
Topics: Adult; Antidiarrheals; Arrhythmias, Cardiac; Humans; Long QT Syndrome; Loperamide; Male; Torsades de | 2021 |
Loperamide-induced cardiotoxicity: a case overlooked?
Topics: Drug Overdose; Electric Countershock; Electrocardiography; Humans; Long QT Syndrome; Loperamide; Mal | 2021 |
Loperamide metabolite-induced cardiomyopathy and QTc prolongation.
Topics: Adult; Antidiarrheals; Biotransformation; Cardiomyopathies; Drug Overdose; Electrocardiography; Fema | 2017 |
An Emerging Malignant Arrhythmia Epidemic Due to Loperamide Abuse: Underlying Mechanisms and Clinical Relevance.
Topics: Anti-Arrhythmia Agents; Antidiarrheals; Arrhythmias, Cardiac; Electrocardiography; Epidemics; Humans | 2016 |
Loperamide misuse to avoid opioid withdrawal and to achieve a euphoric effect: high doses and high risk.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidiarrheals; Arrhythmias, Cardiac; Atrioventricular B | 2019 |
The long QT teaser: loperamide abuse.
Topics: Adult; Antidiarrheals; Arrhythmias, Cardiac; Diagnosis, Differential; Electrocardiography; Fatal Out | 2015 |
Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic.
Topics: Action Potentials; Antidiarrheals; Cardiotoxicity; Dose-Response Relationship, Drug; ERG1 Potassium | 2016 |