loperamide has been researched along with Innate Inflammatory Response in 9 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Resin monomers are the main toxic components in DBA, and the ester group is crucial for monomer toxicity." | 2.77 | Carboxylesterase expression in human dental pulp cells: role in regulation of BisGMA-induced prostanoid production and cytotoxicity. ( Chan, CP; Chang, MC; Chuang, FH; Jeng, JH; Jeng, PY; Lee, JJ; Lin, HJ; Lin, LD; Tseng, WY; Wang, TM, 2012) |
| "Diarrhea is a multifactorial gastrointestinal disorder responsible for about 5 million deaths annually." | 1.62 | Protective effects of Crataegus azarolus L. berries aqueous extract against castor oil-induced diarrhea, oxidative stress, and inflammation in rat. ( Jabri, MA; Jedidi, S; Jridi, M; Rtibi, K; Sammari, H; Sebai, H; Selmi, H; Toumi, L; Zouari, N, 2021) |
| "loperamide was abolished by i." | 1.38 | Relative contributions of peripheral versus supraspinal or spinal opioid receptors to the antinociception of systemic opioids. ( Al-Khrasani, M; Fürst, S; Khalefa, BI; Mousa, SA; Schäfer, M; Shaqura, M, 2012) |
| "Loperamide has potential therapeutic use as a peripherally selective opiate antihyperalgesic agent that lacks many of the side effects generally associated with administration of centrally acting opiates." | 1.30 | Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity. ( Burgos, LC; Cassel, JA; Daubert, JD; DeHaven, RN; DeHaven-Hudkins, DL; Mansson, E; Nagasaka, H; Yaksh, T; Yu, G, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Selby, A | 1 |
| Reichenbach, ZW | 1 |
| Piech, G | 1 |
| Friedenberg, FK | 1 |
| Sammari, H | 1 |
| Jedidi, S | 1 |
| Selmi, H | 1 |
| Rtibi, K | 1 |
| Jabri, MA | 1 |
| Jridi, M | 1 |
| Zouari, N | 1 |
| Toumi, L | 1 |
| Sebai, H | 1 |
| Alam, MM | 1 |
| Emon, NU | 1 |
| Alam, S | 1 |
| Rudra, S | 1 |
| Akhter, N | 1 |
| Mamun, MMR | 1 |
| Ganguly, A | 1 |
| Zanotti-Fregonara, P | 1 |
| Veronese, M | 1 |
| Pascual, B | 1 |
| Rostomily, RC | 1 |
| Turkheimer, F | 1 |
| Masdeu, JC | 1 |
| Zhu, M | 1 |
| Yancy, HF | 1 |
| Deaver, C | 1 |
| Jones, YL | 1 |
| Myers, MJ | 1 |
| Chang, MC | 1 |
| Lin, LD | 1 |
| Chuang, FH | 1 |
| Chan, CP | 1 |
| Wang, TM | 1 |
| Lee, JJ | 1 |
| Jeng, PY | 1 |
| Tseng, WY | 1 |
| Lin, HJ | 1 |
| Jeng, JH | 1 |
| Khalefa, BI | 1 |
| Shaqura, M | 1 |
| Al-Khrasani, M | 1 |
| Fürst, S | 1 |
| Mousa, SA | 1 |
| Schäfer, M | 1 |
| Kimball, ES | 1 |
| Palmer, JM | 1 |
| D'Andrea, MR | 1 |
| Hornby, PJ | 1 |
| Wade, PR | 1 |
| DeHaven-Hudkins, DL | 1 |
| Burgos, LC | 1 |
| Cassel, JA | 1 |
| Daubert, JD | 1 |
| DeHaven, RN | 1 |
| Mansson, E | 1 |
| Nagasaka, H | 1 |
| Yu, G | 1 |
| Yaksh, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double Blind, Placebo Controlled, Cross Over Study to Investigate the Effectiveness and Safety of Eluxadoline in the Treatment of Diabetic Diarrhea[NCT04313088] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2022-07-01 | Withdrawn (stopped due to This study did not enroll any subjects) | ||
| Topical Loperamide Gel for Pain Reduction During Repeat Finger Lancing: A Randomized Double Blind Trial[NCT02711891] | Early Phase 1 | 34 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for loperamide and Innate Inflammatory Response
| Article | Year |
|---|---|
Pathophysiology, Differential Diagnosis, and Treatment of Diabetic Diarrhea.
Topics: Antidiarrheals; Autonomic Nervous System Diseases; Blind Loop Syndrome; Celiac Disease; Diabetes Mel | 2019 |
1 trial available for loperamide and Innate Inflammatory Response
| Article | Year |
|---|---|
Carboxylesterase expression in human dental pulp cells: role in regulation of BisGMA-induced prostanoid production and cytotoxicity.
Topics: Adolescent; Adult; Animals; Antidiarrheals; Bisphenol A-Glycidyl Methacrylate; Carboxylesterase; Cel | 2012 |
7 other studies available for loperamide and Innate Inflammatory Response
| Article | Year |
|---|---|
Protective effects of Crataegus azarolus L. berries aqueous extract against castor oil-induced diarrhea, oxidative stress, and inflammation in rat.
Topics: Animals; Antidiarrheals; Antioxidants; Biphenyl Compounds; Castor Oil; Cathartics; Crataegus; Diarrh | 2021 |
Assessment of pharmacological activities of Lygodium microphyllum Cav. leaves in the management of pain, inflammation, pyrexia, diarrhea, and helminths: In vivo, in vitro and in silico approaches.
Topics: Albendazole; Analgesics; Animals; Anthelmintics; Anti-Inflammatory Agents; Antidiarrheals; Antipyret | 2021 |
The validity of
Topics: Animals; Biomarkers; Biopsy; Blood-Brain Barrier; Brain; Brain Neoplasms; Carbazoles; Fluorine Radio | 2019 |
Loperamide-induced expression of immune and inflammatory genes in Collies associated with ivermectin sensitivity.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dog Diseases; Dogs; Drug Hypersens | 2016 |
Relative contributions of peripheral versus supraspinal or spinal opioid receptors to the antinociception of systemic opioids.
Topics: Analgesics, Opioid; Animals; Fentanyl; Inflammation; Loperamide; Male; Morphine; Pain; Rats; Rats, W | 2012 |
Acute colitis induction by oil of mustard results in later development of an IBS-like accelerated upper GI transit in mice.
Topics: Acute Disease; Animals; Antidiarrheals; Colitis; Colon; Diarrhea; Disease Models, Animal; Gastrointe | 2005 |
Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity.
Topics: Analgesics, Opioid; Animals; Antidiarrheals; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; | 1999 |