Page last updated: 2024-10-30

loperamide and Hypothermia

loperamide has been researched along with Hypothermia in 2 studies

Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.

Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.

Research Excerpts

ExcerptRelevanceReference
"Loperamide significantly induced antinociception, hypothermia, and hypolocomotion (but not catalepsy) at high doses and dose-dependently reduced gastrointestinal motor function, with the intestine exhibiting higher sensitivity than the stomach."7.91Radiographic dose-dependency study of loperamide effects on gastrointestinal motor function in the rat. Temporal relationship with nausea-like behavior. ( Abalo, R; Girón, R; Martín-Fontelles, MI; Vera, G, 2019)
"Loperamide significantly induced antinociception, hypothermia, and hypolocomotion (but not catalepsy) at high doses and dose-dependently reduced gastrointestinal motor function, with the intestine exhibiting higher sensitivity than the stomach."3.91Radiographic dose-dependency study of loperamide effects on gastrointestinal motor function in the rat. Temporal relationship with nausea-like behavior. ( Abalo, R; Girón, R; Martín-Fontelles, MI; Vera, G, 2019)
"We have examined the effects of the psychostimulant d-amphetamine and the neuroleptic haloperidol on hypothermia induced by intraperitoneal injection of the centrally penetrating opioids morphine, fentanyl and sufentanil and the peripherally acting opioid loperamide."3.72Morphine and d-amphetamine nullify each others' hypothermic effects in mice. ( Baker, A; Meert, T, 2003)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Vera, G1
Girón, R1
Martín-Fontelles, MI1
Abalo, R1
Baker, A1
Meert, T1

Other Studies

2 other studies available for loperamide and Hypothermia

ArticleYear
Radiographic dose-dependency study of loperamide effects on gastrointestinal motor function in the rat. Temporal relationship with nausea-like behavior.
    Neurogastroenterology and motility, 2019, Volume: 31, Issue:8

    Topics: Animals; Antidiarrheals; Dose-Response Relationship, Drug; Gastrointestinal Motility; Hypothermia; L

2019
Morphine and d-amphetamine nullify each others' hypothermic effects in mice.
    Pharmacology & toxicology, 2003, Volume: 92, Issue:2

    Topics: Analgesics, Opioid; Animals; Dextroamphetamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Do

2003