loperamide has been researched along with Electrolytes in 15 studies
Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
Electrolytes: Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 2-year-old girl was diagnosed as having acute gastroenteritis with severe diarrhoea, for which she was prescribed a loperamide solution." | 7.72 | [Ileus after the use of loperamide in a child with acute diarrhea]. ( Dudink, J; Mearin, LM; Sukhai, RN, 2003) |
| "To determine whether the antidiarrheal effect of loperamide is due to an effect on intestinal motor function or to an acceleration of the rate of absorption by the intestine (as has been suggested recently), we studied absorption during experimental diarrhea produced by the rapid intragastric infusion of electrolyte solution." | 7.67 | Mechanism of the antidiarrheal effect of loperamide. ( Fordtran, JS; Morawski, SG; Santa Ana, CA; Schiller, LR, 1984) |
| "A 2-year-old girl was diagnosed as having acute gastroenteritis with severe diarrhoea, for which she was prescribed a loperamide solution." | 3.72 | [Ileus after the use of loperamide in a child with acute diarrhea]. ( Dudink, J; Mearin, LM; Sukhai, RN, 2003) |
| "To determine whether the antidiarrheal effect of loperamide is due to an effect on intestinal motor function or to an acceleration of the rate of absorption by the intestine (as has been suggested recently), we studied absorption during experimental diarrhea produced by the rapid intragastric infusion of electrolyte solution." | 3.67 | Mechanism of the antidiarrheal effect of loperamide. ( Fordtran, JS; Morawski, SG; Santa Ana, CA; Schiller, LR, 1984) |
| " opii, loperamide, pethidine and atropine on intestinal transit and the faecal and urinary excretion of water and electrolytes was studied in ponies." | 3.66 | The effect of some anti-diarrhoeal drugs on intestinal transit and faecal excretion of water and electrolytes in the horse. ( Alexander, F, 1978) |
| "Loperamide was also associated with less side effects." | 2.65 | A double-blind crossover study of the effect of loperamide hydrochloride and codeine phosphate on ileostomy output. ( Hill, GL; King, RF; Norton, T, 1982) |
| "Loperamide has been recently indicated in the management of infants with severe protracted diarrhea." | 1.27 | [Effects of loperamide on the fecal flora in children in severe diarrheas]. ( Bingen, E; Cezard, JP; Lambert-Zechovsky, N; Marinier, E; Mashako, L; Navarro, J, 1987) |
| "2 Theophylline caused an increase in short circuit current and reversed the direction of net C1- movement, due mainly to a decrease in mucosal-serosal flux." | 1.27 | Effects of theophylline, choleragen and loperamide on rabbit ileal fluid and electrolyte transport in vitro. ( Ahsan, MA; Ilundain, A; Naftalin, RJ; Sandhu, BK; Smith, PM, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (73.33) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dudink, J | 1 |
| Mearin, LM | 1 |
| Sukhai, RN | 1 |
| Girard, P | 1 |
| Pansart, Y | 1 |
| Coppe, MC | 1 |
| Gillardin, JM | 1 |
| Awouters, F | 1 |
| Niemegeers, CJ | 1 |
| Janssen, PA | 1 |
| Read, NW | 2 |
| Dueñas Laita, A | 1 |
| Fernández de la Gandara, F | 1 |
| Caro-Paton Gómez, A | 1 |
| Casas Carnicero, J | 1 |
| Schiller, LR | 1 |
| Santa Ana, CA | 1 |
| Morawski, SG | 1 |
| Fordtran, JS | 2 |
| King, RF | 1 |
| Norton, T | 1 |
| Hill, GL | 1 |
| Read, MG | 1 |
| Krejs, GJ | 1 |
| Hendler, RS | 1 |
| Davis, G | 1 |
| Weinke, T | 1 |
| Güthoff, W | 1 |
| Liesenfeld, O | 1 |
| Sandhu, B | 1 |
| Tripp, JH | 1 |
| Candy, DC | 1 |
| Harries, JT | 1 |
| Alexander, F | 1 |
| Ramage, JK | 1 |
| Miller, AR | 1 |
| Clarke, PD | 1 |
| Rodrigues, CA | 1 |
| Lennard-Jones, JE | 1 |
| Thompson, DG | 1 |
| Farthing, MJ | 1 |
| Lambert-Zechovsky, N | 1 |
| Bingen, E | 1 |
| Cezard, JP | 1 |
| Mashako, L | 1 |
| Marinier, E | 1 |
| Navarro, J | 1 |
| Ahsan, MA | 1 |
| Ilundain, A | 1 |
| Naftalin, RJ | 1 |
| Sandhu, BK | 1 |
| Smith, PM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Brain and Whole Body Imaging of P-Glycoprotein Function Using [11C]dLop[NCT00605254] | 58 participants (Actual) | Observational | 2008-01-24 | Completed | |||
| An Open-label, Randomized, Fasting, Two-period, Single-dose, Crossover Study to Assess Bioequivalence Between a Combination Caplet With Loperamide Hydrochloride and Simethicone (Janssen-Cilag, France), and Imodium® Express Tablets-lyophilizate (Janssen-Ci[NCT04186936] | Phase 1 | 48 participants (Actual) | Interventional | 2019-12-05 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for loperamide and Electrolytes
| Article | Year |
|---|---|
Pharmacology of antidiarrheal drugs.
Topics: Animals; Antidiarrheals; Biological Transport; Body Fluids; Castor Oil; Diarrhea; Diphenoxylate; Ele | 1983 |
Pharmacology of antidiarrheal drugs.
Topics: Animals; Antidiarrheals; Biological Transport; Body Fluids; Castor Oil; Diarrhea; Diphenoxylate; Ele | 1983 |
Pharmacology of antidiarrheal drugs.
Topics: Animals; Antidiarrheals; Biological Transport; Body Fluids; Castor Oil; Diarrhea; Diphenoxylate; Ele | 1983 |
Pharmacology of antidiarrheal drugs.
Topics: Animals; Antidiarrheals; Biological Transport; Body Fluids; Castor Oil; Diarrhea; Diphenoxylate; Ele | 1983 |
Speculations on the role of motility in the pathogenesis and treatment of diarrhoea.
Topics: Animals; Body Water; Colon; Diarrhea; Dogs; Electrolytes; Gastrointestinal Motility; Humans; Intesti | 1983 |
[Traveller's diarrhea].
Topics: Anti-Infective Agents; Antidiarrheals; Bacterial Infections; Diarrhea; Diet; Electrolytes; Feces; Fl | 1998 |
2 trials available for loperamide and Electrolytes
| Article | Year |
|---|---|
A double-blind crossover study of the effect of loperamide hydrochloride and codeine phosphate on ileostomy output.
Topics: Adult; Aged; Body Weight; Clinical Trials as Topic; Codeine; Diarrhea; Double-Blind Method; Electrol | 1982 |
Acute diarrhoea in expatriates in Bangladesh.
Topics: Diarrhea; Drug Combinations; Drug Therapy, Combination; Electrolytes; Glucose; Humans; Loperamide; M | 1990 |
10 other studies available for loperamide and Electrolytes
| Article | Year |
|---|---|
[Ileus after the use of loperamide in a child with acute diarrhea].
Topics: Antidiarrheals; Child, Preschool; Diarrhea; Electrolytes; Female; Fluid Therapy; Gastroenteritis; Hu | 2003 |
Saccharomyces boulardii inhibits water and electrolytes changes induced by castor oil in the rat colon.
Topics: Animals; Antidiarrheals; Atropine; Castor Oil; Colon; Diarrhea; Electrolytes; Loperamide; Male; Rats | 2005 |
[Changes in water, glucose, and electrolyte transport in the rat intestine "in vivo" after intraluminal injection of loperamide and aspirin].
Topics: Animals; Aspirin; Biological Transport; Electrolytes; Glucose; Intestine, Small; Loperamide; Male; P | 1983 |
Mechanism of the antidiarrheal effect of loperamide.
Topics: Adult; Antidiarrheals; Diarrhea; Electrolytes; Gastrointestinal Motility; Humans; Intestinal Absorpt | 1984 |
A report of five patients with large-volume secretory diarrhea but no evidence of endocrine tumor or laxative abuse.
Topics: Adult; Aged; Cathartics; Chronic Disease; Colon; Diarrhea; Electrolytes; Endocrine System Diseases; | 1982 |
Loperamide inhibits cholera-toxin-induced small-intestinal secretion.
Topics: Animals; Cholera Toxin; Diarrhea; Electrolytes; Jejunum; Loperamide; Male; Piperidines; Rats; Water | 1979 |
The effect of some anti-diarrhoeal drugs on intestinal transit and faecal excretion of water and electrolytes in the horse.
Topics: Animals; Antidiarrheals; Atropine; Electrolytes; Feces; Gastrointestinal Motility; Horses; Loperamid | 1978 |
The effects of octreotide, soy polysaccharide, codeine and loperamide on nutrient, fluid and electrolyte absorption in the short-bowel syndrome.
Topics: Codeine; Drug Therapy, Combination; Electrolytes; Gastrointestinal Transit; Humans; Intestinal Absor | 1989 |
[Effects of loperamide on the fecal flora in children in severe diarrheas].
Topics: Child, Preschool; Diarrhea, Infantile; Electrolytes; Enterobacteriaceae; Enterococcus faecalis; Esch | 1987 |
Effects of theophylline, choleragen and loperamide on rabbit ileal fluid and electrolyte transport in vitro.
Topics: Animals; Body Fluids; Bromides; Chlorides; Cholera Toxin; Electrolytes; Ileum; In Vitro Techniques; | 1987 |